KR20220114763A - Multi moisturizing agent for cosmetics, Manufacturing method thereof and cosmetics containing the same - Google Patents

Abstract

The present invention relates to a multi-moisturizing agent for oil-in-water cosmetics, a manufacturing method thereof, and oil-in-water cosmetics including the same, and relates to a multi-moisturizing agent for oil-in-water cosmetics which is manufactured to make active ingredients micronized by using a microfluidizer (MF) reach the dermal layer, a manufacturing method thereof, and oil-in-water cosmetics including the same.

Description

Multi moisturizing agent for cosmetics, manufacturing method thereof, and cosmetics comprising the same

The present invention relates to a multi-moisturizer prepared so that an active ingredient micronized using MF (Microfluidizer, high-pressure liquid emulsifier) reaches the dermal layer, a method for preparing the same, and an oil-in-water cosmetic comprising the same, as well as moisturizing the skin , It relates to a multi-moisturizer with various skin improvement functions such as soothing effect, and cosmetics using the same.

The skin protects the body, contains nerve endings that can be felt when stimulated from the outside, and is responsible for chemical and physical reactions such as thermoregulation and vitamin synthesis.

The skin is largely divided into epidermis, dermis, and subcutaneous tissue. The dermis contains more water than the epidermis and provides nutrients to the epidermis. When the epidermis lacks nutrients or moisture, the dermis supplies moisture and nutrients, so it is necessary to protect the skin and supply moisture so that the epidermal layer does not lose moisture from the outside. If moisture supply is not smooth, skin dryness occurs and the binding force of keratinocytes decreases, providing nutrition to the moisture balance of the epidermis, including the stratum corneum, and the dermis. In order to reduce these effects, it is necessary to protect the skin and provide sufficient moisture and nutrition to maintain healthy skin. In particular, skin is a visible part, and it is essential to maintain skin moisture because it takes up a lot of weight in determining aesthetic beauty.

If the skin lacks moisture, most people say that the skin is dry. However, dry skin is not necessarily caused by a decrease in skin moisture content. It has been reported that drying of the skin is improved by frequently applying a moisturizer when the skin feels dry. In order to improve this drying phenomenon, many cosmetics including various moisturizers have been disclosed to maintain skin moisture so that it does not decrease, but it has a problem that it is difficult to maintain it continuously. In order to improve these problems, the present invention was completed.

Korean Patent Publication No. 10-2004-0021695 (published on March 10, 2004) Korean Patent Publication No. 10-2020-0010259 (published on January 30, 2020)

The present invention is an oil-in-water (O/W, oil-in-water) cosmetic that is harmless to the human body and has no skin troubles, and has excellent skin moisturizing properties and skin soothing effects, due to the characteristics of the product in direct contact with the skin. , It is an object of the invention to provide a multi-moisturizer used therein and a method for preparing the same.

The present invention for solving the above problems relates to a method for manufacturing a multi-moisturizing agent for cosmetics, comprising: a first step of adding a solvent to a reactor and heating; A second step of preparing a first solution by adding a complex moisturizing agent to the soluble solvent, stirring, and dissolving; After cooling the first solution, a third step of preparing a second solution by adding a skin conditioning mixture to the cooled solution and then dissolving; and a fourth step of cooling the second solution and then performing a defoaming treatment.

Another object of the present invention is to provide a multi-moisturizer for oil-in-water type cosmetics comprising 0.1 to 1% by weight of a complex moisturizer, 65 to 75% by weight of a skin conditioning mixture, and the remaining amount of a solvent.

Another object of the present invention is to provide a cosmetic comprising the multi-moisturizer.

The multi-moisturizer of the present invention is suitable for use in oil-in-water cosmetics, and the active ingredient emulsified in the moisturizer is well absorbed into the dermal layer of the skin by micronizing the active ingredient particles through a low-molecular method using a microfluidizer (MF). can be reached In addition, the multi-moisturizer of the present invention contains a variety of skin-improving functional ingredients as well as a moisturizing effect, so it is possible to prepare a cosmetic excellent in skin moisturizing properties, antioxidant properties, skin elasticity improvement and skin soothing effect without skin troubles. .

Hereinafter, the present invention will be described in more detail through a method of manufacturing a multi-moisturizer for cosmetics.

The present invention is a first step of putting a solvent in a reactor and heating; A second step of preparing a first solution by adding a complex moisturizing agent to the soluble solvent, stirring, and dissolving; After cooling the solution, a third step of preparing a second solution by adding a skin conditioning mixture to the cooled solution, stirring and dissolving; and a fourth step of cooling the second solution and then defoaming to prepare a multi-moisturizer for oil-in-water type cosmetics.

As the solvent in step 1, an aqueous ethanol solution or water may be used, and purified water (purified water) is preferably used. It is recommended that the heating is about 70 ° C to 85 ° C, preferably 75 ° C to 85 ° C, and more preferably about 78 to 83 ° C. and exceeding 85°C is uneconomical.

Next, the second step is a step of preparing a first solution by dissolving the complex moisturizing agent in a warmed solvent, and the second step is at the same or slightly lower temperature as the first step (65 to 80° C., preferably 65 to 75° C.) It is carried out under the solvent of, and the stirring and dissolution of the second step is preferably carried out for 40 minutes to 80 minutes under a stirring speed of 500 to 1,000 rpm, preferably for about 50 to 70 minutes under 700 to 950 rpm. At this time, if the stirring speed is less than 500 rpm or the stirring time is less than 40 minutes, the complex moisturizing agent may not dissolve well, and if the stirring speed exceeds 1,000 rpm, bubbles may occur, and if the stirring time exceeds 80 minutes, It is uneconomical.

The complex moisturizing agent of step 2 may include one or more of ultra-low molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate, and medium molecular weight sodium hyaluronate, and preferably, ultra low molecular weight sodium hyaluronate to improve moisturizing durability. And two kinds of low molecular weight sodium hyaluronate, more preferably, it may include three kinds of ultra-low molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and medium molecular weight sodium hyaluronate.

And, when the sodium hyaluronate is mixed and used, ultra-low molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and medium molecular weight sodium hyaluronate are used in a weight ratio of 1: 0.8 to 1.5, preferably, the ultra low molecular weight sodium hyaluronate, the low molecular weight sodium hyaluronate And containing the sodium hyaluronate medium molecular weight in a weight ratio of 1: 0.90 to 1.35: 0.70 to 1.10 is good in terms of maximizing moisturizing power, lasting moisture, and compatibility with other ingredients in the skin conditioning mixture.

And, the ultra-low molecular weight sodium hyaluronate has a weight average molecular weight of less than 10,000 Daltons, preferably a weight average molecular weight of 5,000 to 7,000 Daltons, and more preferably a weight average molecular weight of 6,000 to 6,800 Daltons.

In addition, the low molecular weight sodium hyaluronate may have a weight average molecular weight of 10,000 to 200,000 daltons, preferably 20,000 to 160,000 daltons, more preferably 25,000 to 150,000 daltons.

In addition, the medium molecular weight sodium hyaluronate may have a weight average molecular weight of 200,000 to 1,600,000 Daltons, preferably 225,000 to 1,200,000 Daltons, and more preferably a weight average molecular weight of 300,000 to 1,000,000 Daltons.

In addition, when preparing the solution in the second step, the emulsion stabilizer may be further used in addition to the complex moisturizer, and as the emulsion stabilizer, a general emulsion stabilizer used in the art may be used, but preferably a small amount of carbomer , Preferably, 2 to 5 parts by weight may be used with respect to 100 parts by weight of the complex moisturizer.

Next, in step 3, the first solution is cooled to 50° C. or less, preferably 35 to 50° C., and then a skin conditioning mixture is added to the cooled first solution, followed by stirring and dissolving to dissolve the second solution. to manufacture At this time, the stirring and dissolution is a high pressure liquid emulsification method using a high pressure liquid emulsifier (microfluidizer) under a pressure of about 800 ~ 1,500 bar pressure, preferably 800 ~ 1,200 bar for 10 ~ 30 minutes, preferably for 10 ~ 20 minutes And it is possible to prepare a second solution in which the active ingredient particles are pulverized through this low-molecular method, in which the moisturizing agent and the skin conditioning mixture component are evenly emulsified. And, when performing the high-pressure liquid emulsification method, at this time, the temperature inside the ultra-high pressure disperser is 50 ~ 80 ℃, the outlet temperature of the ultra-high pressure disperser is about 10 ~ 15 ℃.

The skin conditioning admixture of step 3 includes microbial fermentation filtrate, propanediol, butylene glycol and a humectant.

The microbial fermentation filtrate among the ingredients of the skin conditioning mixture is described as follows.

The microbial fermentation filtrate includes Lactobacillus fermentation filtrate, Bifida fermentation filtrate, yeast fermentation filtrate and 1,2-hexanediol, preferably 30-40 wt% of Lactobacillus fermentation filtrate, Bifida fermentation 25 to 36% by weight of the filtrate, 20 to 35% by weight of the yeast fermentation filtrate, and the remaining amount of 1,2-hexanediol, more preferably 30 to 38% by weight of the Lactobacillus fermentation filtrate, Bifida fermentation filtration 26 to 32% by weight of water, 22 to 30% by weight of yeast fermentation filtrate and the balance of 1,2-hexanediol.

The Lactobacillus fermentation filtrate is inoculated with Lactobacillus-based lactic acid bacteria in a plant extract mixture prepared by mixing 9 types of plant extracts, and then in the dark and anaerobic conditions at 20 ~ 40 ℃, preferably at a temperature of 30 ~ 35 ℃ It is a filtrate obtained by fermenting for 24 hours or more, preferably 24 to 36 hours, and then heating the fermented product at 70 to 90° C. for 5 to 20 minutes to kill lactic acid bacteria, followed by filtration. In addition, the inoculation of Bacillus-based lactic acid bacteria is preferably 1×10 ⁵ to 1×10 ⁸ CFU, preferably 5×10 ⁵ to 5×10 ⁷ CFU in 1 mL of the plant extract mixture. In addition, as the Lactobacillus-based lactic acid bacteria, one type selected from Lactobacillus bacteria, Streptococcus thermophilus and Lactobacillus lactic can be used alone or by mixing two or more types. have.

Here, the nine plant extracts include centella asiatica extract, cheongho extract, licorice extract, neem leaf extract, comfrey leaf extract, green tea extract, purslane extract, rosemary extract, and elm bark extract. Preferably, based on 100 parts by weight of centella asiatica extract, 60 to 100 parts by weight of chungho extract, 60 to 100 parts by weight of licorice extract, 30 to 70 parts by weight of neem leaf extract, 30 to 70 parts by weight of comfrey extract, 15 to 50 parts by weight of green tea extract parts, including 15 to 50 parts by weight of purslane extract, 10 to 45 parts by weight of rosemary extract and 10 to 45 parts by weight of elm bark extract, more preferably 70 to 90 parts by weight of cheongho extract based on 100 parts by weight of centella asiatica extract , licorice extract 60 to 85 parts by weight, neem leaf extract 35 to 55 parts by weight, comfrey leaf extract 35 to 60 parts by weight, green tea extract 25 to 40 parts by weight, purslane extract 20 to 40 parts by weight, rosemary extract 15 to 38 parts by weight, and It is good to include 15 to 35 parts by weight of the extract of the elm bark extract.

At this time, if the extract of Cheongho extract is less than 60 parts by weight, there may be no skin regeneration effect on damaged skin, and if it exceeds 100 parts by weight, there may be a problem of rather causing a price increase and skin troubles. In addition, if the licorice extract is less than 60 parts by weight, there may be no effect to soothe irritated skin, and if it exceeds 100 parts by weight, there may be a problem in that only the manufacturing cost increases due to excessive use. In addition, if the neem leaf extract is less than 30 parts by weight, there may be no effect of alleviating itching and inflammation of the skin, and if it exceeds 70 parts by weight, there may be a problem of causing skin troubles. In addition, if the comfrey leaf extract is less than 30 parts by weight, there may be no soothing effect on the private skin area, and if it exceeds 70 parts by weight, it is uneconomical. In addition, if the green tea extract is less than 15 parts by weight, there may be no effect of reducing skin troubles through the antioxidant effect, and if it exceeds 50 parts by weight, it is uneconomical. In addition, if the amount of the purslane extract is less than 15 parts by weight, the effect of improving skin trouble alleviation may be reduced, and if it exceeds 50 parts by weight, there may be a problem that fermentation by microorganisms is not good during fermentation. In addition, if the rosemary extract is less than 10 parts by weight, the effect of giving vitality to the sagging skin tissue may be insignificant, and if it exceeds 45 parts by weight, it is uneconomical. In addition, if the extract is less than 10 parts by weight, skin elasticity improvement and skin vitality improvement effect may be insufficient, and if it exceeds 45 parts by weight, there may be a problem in that fermentation by microorganisms does not work well during fermentation.

에서 4 ~ 14 시간 동안, 바람직하게는 6 ~ 12 시간 동안 진공 저온 추출하여 병풀 추출물을 제조할 수 있다.Each extract of the plant extraction mixture may be prepared through a general extraction method used in the art, and preferably may be prepared through a vacuum low temperature extraction method, an ultrasonic extraction method, or the like. For a preferred embodiment, the Centella asiatica extract is prepared by mixing dried Centella asiatica in a solvent (butylene glycol, ethanol and distilled water in a ratio of 40 to 60: 20 to 30: 20 to 30 by volume) in a ratio of 1:1 to 30 by weight. After, 60 to 80

Centella asiatica extract can be prepared by vacuum low temperature extraction for 4 to 14 hours, preferably for 6 to 12 hours.

In addition, the cheongho extract, licorice extract, neem leaf extract, comfrey leaf extract, green tea extract, purslane extract, rosemary extract and sugar elm bark extract can all be prepared using the same solvent and method as the centella asiatica extract described above.

Among the components of the microbial fermentation filtrate, the Bifida Ferment Filtrate is a cosmetic ingredient registered in ICID, and is a material filtered by fermenting Bifidobacteria, an anaerobic lactic acid bacteria present in the digestive system. Bifida ferment filtrate activates oxygen supply in the skin as a component that helps cell regeneration and barrier strengthening. By strengthening the skin barrier, it improves rough skin and regulates the skin rhythm, improving skin tone, supplying moisture and nutrition, and giving a lively application without stickiness. In addition, it is used as a raw material for cosmetics and is known to play a role in eliminating toxicity.

In addition, among the components of the microbial fermentation filtrate, the yeast fermentation filtrate (Saccharomyces Ferment Filtrate) is a fermentation filtrate of Saccharomyces, a natural yeast used for making bread or beer, and is rich in amino acids, nucleic acids, peptides, minerals, and vitamins. . Yeast fermentation filtrate contains the natural moisturizing factor NMF, and contains more than 30% of amino acids, 15% of nucleic acids, and 30% of peptides. It is known to be shiny.

Among the components of the microbial fermentation filtrate, the 1,2-hexanediol serves as a solvent for the fermentation filtrate.

In the present invention, the skin conditioning mixture is based on 100 parts by weight of the microbial fermentation filtrate, 700 to 900 parts by weight of propanediol, 750 to 950 parts by weight of butylene glycol, and 500 to 1,000 parts by weight of a wetting agent, preferably the microorganism Based on 100 parts by weight of the fermentation filtrate, 750 to 880 parts by weight of propanediol, 750 to 930 parts by weight of butylene glycol, and 600 to 900 parts by weight of a wetting agent may be included.

As the wetting agent, a commercially available product generally used in the art may be used, and as a preferred example, purified glycerin may be used.

In addition, the skin conditioning mixture may further include other cosmetic ingredients such as a preservative, an anti-foaming agent, a whitening agent, and a fragrance.

And, after cooling the second solution prepared in step 3 to 20 ℃ ~ 30 ℃, preferably 25 ℃ ~ 30 ℃, it is possible to prepare a multi-moisturizer for oil-in-water cosmetic by defoaming treatment.

The multi-moisturizer for oil-in-water type cosmetic of the present invention prepared in this way includes 0.1 to 1% by weight of the complex moisturizer, 65 to 85% by weight of the skin conditioning mixture, and the remaining amount of the solvent, preferably 0.1 to 0.5% by weight of the complex moisturizer %, 72 to 82% by weight of the skin conditioning mixture and the remaining amount of the solvent. In this case, the solvent is the solvent of step 1. If the content of the complex moisturizer in the multi-moisturizer is less than 0.1% by weight, the moisturizing effect may be insufficient, and if it exceeds 1% by weight, the viscosity of the multi-humectant is rather high and the feeling of stickiness is reduced, so it is recommended to use it within the above range.

The multi-moisturizer for oil-in-water type cosmetics of the present invention has no skin troubles, has excellent skin soothing, skin antioxidant, skin homeostasis, and skin aging prevention effects, and has excellent skin moisturizing properties, including toner, ampoule, essence, and mask pack. It is suitable for application as a cosmetic when manufacturing oil-in-water type cosmetics having formulations such as , serum mist, etc.

Hereinafter, the present invention will be described in more detail through examples, but the following examples are not intended to limit the scope of the present invention, which should be construed to aid understanding of the present invention.

[Example]

Preparation Example 1-1: Preparation of complex moisturizing agent

Ultra-low molecular weight sodium hyaluronate having a weight average molecular weight of 6,500 to 6,800 Daltons, low molecular weight sodium hyaluronate having a weight average molecular weight of 50,000 to 60,000 Daltons, and medium molecular weight sodium hyaluronate having a weight average molecular weight of 350,000 to 375,000 are mixed in a weight ratio of 1:1.05:0.98 to composite A moisturizer was prepared.

Preparation Example 1-2

A complex moisturizer was prepared by mixing ultra-low molecular weight sodium hyaluronate having a weight average molecular weight of 6,500 to 6,800 daltons and low molecular weight sodium hyaluronate having a weight average molecular weight of 50,000 to 60,000 daltons in a 1:1 weight ratio.

Comparative Preparation Example 1-1

Ultra-low molecular weight sodium hyaluronate having a weight average molecular weight of 6,500 to 6,800 Daltons was prepared as a moisturizer.

Preparation Example 2: Preparation of skin conditioning mixture

(1) Preparation of Lactobacillus fermentation filtrate

Put dried Centella asiatica in a solvent of butylene glycol/ethanol/distilled water (50/25/25 volume ratio) in a high-speed vacuum low-temperature extractor (Kyungseo Machinery, COSMOS-660) at a weight ratio of 1:5, and extracted at about 75°C for 12 hours. Centella asiatica extract was obtained. The obtained extract was distilled to recover the organic solvent. The concentration of the extract was about 5%. It was concentrated again to remove about 50% of moisture in the extract. The thus obtained Centella asiatica extract was stored in a refrigerator (about 3° C.).

Cheongho, licorice, neem leaf, comfrey leaf, green tea, purslane, rosemary and elm bark respectively prepared in the same manner as the above centella asiatica extract, cheongho extract, licorice extract, neem leaf extract, comfrey leaf extract, green tea extract, purslane extract, rosemary extract and extracts of elm bark were prepared, respectively.

Next, with respect to 100 parts by weight of the Centella asiatica extract, 75 parts by weight of chungho extract, 75 parts by weight of licorice extract, 45 parts by weight of neem leaf extract, 45 parts by weight of comfrey extract, 31.5 parts by weight of green tea extract, 31.5 parts by weight of purslane extract, rosemary A plant extract mixture was prepared by mixing 31.5 parts by weight of the extract and 31.5 parts by weight of the extract of elm bark extract.

After inoculating 1.2×10 ⁶ to 1.5×10 ⁶ CFU of Lactobacillus bacteria, which are Lactobacillus-based lactic acid bacteria, in 1 mL of the plant extraction mixture, in a dark room and anaerobic conditions at a temperature of about 30 to 32° C. for 26 hours After fermentation, the fermented product was heated at 85° C. for 15 minutes to kill lactic acid bacteria, and then filtered to prepare a Lactobacillus fermentation filtrate.

(2) Preparation of microbial fermentation filtrate

remind 32.5% by weight of Lactobacillus fermentation filtrate, 32.0% by weight of Bifida fermentation filtrate, 29.0% by weight of yeast fermentation filtrate, and the remaining amount of 1,2-hexanediol were mixed and slowly stirred at 20 to 25° C. to prepare a microbial fermentation filtrate prepared.

(3) Preparation of skin conditioning mixture

With respect to 100 parts by weight of the microbial fermentation filtrate, 825 parts by weight of propanediol, 820 parts by weight of butylene glycol, and 665 parts by weight of a wetting agent were put into the tank, and then stirred at 40° C. at 500 rpm for 15 minutes to prepare a skin conditioning mixture did.

Example 1: Preparation of multi-moisturizer for oil-in-water cosmetics

Purified water was added to the reaction tank and heated to 80°C.

Next, after adding the complex moisturizing agent prepared in Preparation Example 1-1 to the warmed purified water, the mixture was stirred for 60 minutes at a temperature of 70° C. and a stirring speed of 800 rpm to prepare a first solution.

Next, after cooling the first solution to 40° C., the cooled first solution is put into a high-pressure liquid emulsifier (microfluidizer), and then the skin conditioning mixture prepared in Preparation Example 2 is added, and then about A second solution was prepared by pulverization by high pressure liquid emulsification method for 20 minutes under a pressure of 1,050 bar. At this time, the internal temperature of the ultra-high pressure disperser was about 70 °C, and the outlet temperature of the ultra-high pressure disperser was about 15 °C.

In the second solution, the complex moisturizer component and the skin conditioning mixture component were homogeneously pulverized and emulsified.

Next, the second solution was cooled to 30° C. and then subjected to defoaming treatment to obtain a multi-moisturizer for oil-in-water cosmetics.

Examples 2 to 3 and Comparative Examples 1 to 3

A multi-moisturizer for oil-in-water type cosmetics was prepared in the same manner as in Example 1, but the composition was changed as shown in Table 1 to prepare a multi-moisturizer, and Examples 2 to 3 and Comparative Examples 1 to 3 were carried out, respectively.

division complex moisturizer skin conditioning mixture menstruum type content
(weight%) type content
(weight%) type content
(weight%) Example 1 Preparation Example 1-1 0.3 Preparation Example 2 77.2 Purified water 100% by weight
remaining balance Example 2 Preparation Example 1-2 0.3 Preparation Example 2 77.2 Purified water Example 3 Preparation Example 1-1 0.5 Preparation Example 2 77.2 Purified water Comparative Example 1 Comparative Preparation Example 1-1 0.3 Preparation Example 2 77.2 Purified water Comparative Example 2 Preparation Example 1-1 0 Preparation Example 2 77.2 Purified water Comparative Example 3 Preparation Example 1-1 1.2 Preparation Example 2 77.2 Purified water

Experimental Example 1: Skin patch experiment

The lotion for the mask pack prepared in Examples 1 to 3 was requested to the OATC Skin Clinical Test Center, and a skin clinical test was performed. There were a total of 20 test participants (females between 20 and 60 years old, average age of 46.32 years), and the test method is shown in Table 2 below, and the irritation evaluation criteria and skin irritation index calculation formula are in Table 3 and Figure equal to 1.

Test Methods 1. Patch area: Wipe the area without coloring or skin damage with 70% ethanol with a flat area on the subject's back except for the spine, dry, load 20 μl of the test product, fix it on the skin, and apply it for 24 hours. , assessments were performed 30 minutes and 24 hours after patch removal.
2. Evaluation: Visual evaluation by a dermatologist
3. Determination of presence or absence of stimulation: Frosch&Kligman, CTFA guideline, and Draize method are applied.

skin irritation index Irritation Assessment 0.00 to 0.25 Non (non-irritating) 0.26 to 1.00 weak acid irritant 1.01 to 2.50 Moderate irritation 2.51 to 4.00 strong irritant

[Figure 1]

As a result of skin patch measurement, the multi-moisturizer of Examples 1 to 3 was determined to be non-irritating (see Table 4).

division skin reaction Stimulation
Indices pepper
evaluation Example 1 30 minutes passed 24 hours elapsed 0.00 Non (non) irritant 0 0 Example 2 30 minutes passed 24 hours elapsed 0.00 Non (non) irritant 0 0 Example 3 30 minutes passed 24 hours elapsed 0.00 Non (non) irritant 0 0

Experimental Example 2: Evaluation of skin moisturizing and moisturizing durability

The clinical moisturizing effect and lasting power of the multi-moisturizer prepared in Examples and Comparative Examples were measured as follows. The multi-moisturizers of Examples 1 to 3 and Comparative Examples 1 to 3 were applied to the forearms of 30 healthy adult men and women who felt that their skin was dry through a survey, respectively, twice a day for 1 week. The moisturizing effect was evaluated by quantifying the increase rate (%) of skin electrical conductivity according to the amount of moisture in the epidermis using Corneometer CM 820 (Corage +Khazaka, Germany) for the improvement effect after the start of the actual use test. The experimental results are shown in Table 5 below. Each of the numerical values in Table 5 below represents the average value of 30 people.

division 0 weeks 2 weeks rate of change (%) Example 1 22.7% 43.0% 20.3% Example 2 23.2% 41.1% 17.9% Example 3 23.5% 44.7% 21.2% Comparative Example 1 23.2% 34.6% 11.4% Comparative Example 2 22.4% 30.7% 8.3% Comparative Example 3 22.9% 44.3% 21.4%

Looking at the experimental results in Table 5, Comparative Example 2, which did not use a complex moisturizer, showed a relatively large decrease in moisture retention compared to Examples 1 to 3, Comparative Examples 1 and 3, and Comparative Example 3.

And, in the case of Comparative Example 1 prepared by using only ultra-low molecular weight sodium hyaluronate as a moisturizing component, the moisturizing power is good compared to Comparative Example 2, but compared with Examples 1 and 2, the moisturizing property is relatively large. showed poor results.

In addition, in the case of Comparative Example 3 in which the complex moisturizer was used in excess of 1 wt %, the moisturizing effect synergistic effect was insufficient when compared with Example 3 in which the complex moisturizer was used in 0.5 wt %.

Experimental Example 3: Skin elasticity improvement effect

In order to test the effect of improving elasticity in actual human skin, Examples 1 to 3 and Comparative Examples 1 to 2 were used as follows. Forty women in their 30s and 40s were divided into 4 groups of 10 people each, and Examples 1 to 3 and Comparative Examples 1 to 2 were given to each group, and then applied to the face once every morning and evening for 1 week.

After 1 week, the skin elasticity improvement effect (skin viscoelasticity, viscoelasticity) was measured using a skin elasticity measuring instrument (Cutometer SEM 575, C+K Electronic Co., Germany), and the results are shown in Table 6 below. The control group in Table 6 below is a case where a multi-moisturizer is not used, and the results in Table 6 are expressed by obtaining the skin elasticity improvement effect based on this.

division skin elasticity effect control 100% Example 1 116.1% Example 2 112.6% Example 3 118.2% Comparative Example 1 109.5% Comparative Example 2 107.7%

Referring to Table 6, in the case of Examples 1 to 3, it can be confirmed that the skin elasticity enhancing effect is excellent. On the other hand, Comparative Examples 1 to 2 showed relatively poor skin elasticity effect when compared with Examples 1 to 3.

Experimental Example 4: Measurement of skin sebum control effect

In order to confirm the skin sebum control effect, the essence sample of the composition of Table 7 below was used as a control on both sides of the subject's forehead for 10 adult men and women in their early 20s, and the multi-moisturizer of Example 1 was applied as a sample, respectively. After that, the amount of sebum was monitored while waiting in a constant temperature and humidity room for 6 hours. Using a sebumeter, the amount of sebum (ug/cm2) on the forehead was measured before sample use, 2 hours after sample use, and 6 hours after sample use. Essence components are shown in Table 7 below, and the measurement results for skin sebum control are shown in Table 8 below.

Raw material Content (wt%) sitosterol 1.6 C 12-20 Acid PEG-8 Ester 1.6 ceramide 0.5 Seteth-4 1.2 cholesterol 1.4 butylene glycol 5.0 dicetyl phosphate 0.5 cyclomethicone 0.5 Carboxyvinyl Polymer 0.5 xanthan gum 0.1 antiseptic 0.02 Sunflower Seed Oil 11.5 Purified water remaining balance

division control
(ug/cm2) Example 1
(ug/cm2) 0 63 60 2 hours 135 131 6 hours 178 167

Looking at Table 8, when treated with the multi-moisturizer of the present invention compared to the control essence, it can be seen that the amount of pizza is significantly reduced over time, and through this, the multi-moisturizer of the present invention is excellent for controlling skin sebum as a cosmetic. I was able to confirm that I had the ability.

Through the above examples and experimental examples, it was confirmed that the multi-moisturizer of the present invention is harmless to the human body and has no skin troubles, and has skin moisturizing properties, skin soothing effects, and skin elasticity improvement effects.

Claims (10)

Step 1 of heating the solvent to 70 ~ 85 ℃ into the reactor;
A second step of preparing a first solution by adding a complex moisturizer to the soluble solvent and stirring and dissolving it under 65 to 80°C;
After cooling the first solution to 35 ~ 50 ℃, after adding a skin conditioning mixture to the cooled solution, the third step of dissolving to prepare a second solution; and
A method for manufacturing a multi-moisturizing agent for cosmetics, comprising: cooling the second solution to 20 to 30° C. and then defoaming treatment.
The method of claim 1, wherein the stirring of the second step is carried out for 40 minutes to 80 minutes under a stirring speed of 500 to 1,000 rpm,
The three-step dissolution is a method of manufacturing a multi-moisturizing agent for cosmetics, characterized in that it is performed by a high-pressure liquid emulsification method.
According to claim 1, wherein the solvent of step 1 comprises water,
The two-step complex moisturizer contains ultra-low molecular weight sodium hyaluronate with a weight average molecular weight of less than 10,000 Daltons, low molecular weight sodium hyaluronate with a weight average molecular weight of 10,000 to 200,000, and medium molecular weight sodium hyaluronate with a weight average molecular weight of 200,000 to 1,600,000. A method for manufacturing a multi-moisturizing agent for cosmetics, comprising at least one selected from among.
[Claim 4] The multi-moisturizer for cosmetics according to claim 3, wherein the complex moisturizer comprises the ultra-low molecular weight sodium hyaluronate, the low molecular weight sodium hyaluronate, and the medium molecular weight sodium hyaluronate in a weight ratio of 1: 0.8 to 1.5: 0.5 to 1.2 by weight. manufacturing method.
The method according to claim 1, wherein the skin conditioning mixture comprises 700 to 900 parts by weight of propanediol, 750 to 950 parts by weight of butylene glycol, and 500 to 1,000 parts by weight of a humectant based on 100 parts by weight of the microbial fermentation filtrate. A method for manufacturing a multi-moisturizer for cosmetics.
6. The method of claim 5, wherein the microbial fermentation filtrate is
Lactobacillus fermentation filtrate, Bifida fermentation filtrate, yeast fermentation filtrate, and a method for manufacturing a multi-moisturizing agent for cosmetics comprising 1,2-hexanediol.
7. The method according to claim 6, wherein the microbial fermentation filtrate comprises 30 to 40% by weight of Lactobacillus fermentation filtrate, 25 to 36% by weight of Bifida fermentation filtrate, 20 to 35% by weight of yeast fermentation filtrate, and the balance of 1,2- A method for manufacturing a multi-moisturizing agent for cosmetics, comprising hexanediol.
0.1 to 1% by weight of the complex moisturizer, 65 to 75% by weight of the skin conditioning mixture, and the remaining amount of the solvent,
The skin conditioning mixture comprises 700 to 900 parts by weight of propanediol, 750 to 950 parts by weight of butylene glycol, and 500 to 1,000 parts by weight of a humectant based on 100 parts by weight of the microbial fermentation filtrate.
The method of claim 8, wherein the complex moisturizing agent comprises ultra-low molecular weight sodium hyaluronate (Sodium Hyaluronate) of less than 10 kDa, low molecular weight sodium hyaluronate of 10-200 kDa, and medium-molecular weight sodium hyaluronate of 200-1600 kDa. multi-moisturizer for cosmetics
A cosmetic comprising the multi-moisturizer of claim 8 or 9.