CN110075032A - A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate and preparation method thereof rich in function factor - Google Patents
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate and preparation method thereof rich in function factor Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The present invention provides a kind of compound oil-in-water emulsion of xanthan gum/sodium alginate and preparation method thereof rich in function factor, the lotion includes that the following raw material is made: oily phase, emulsifier, alcohol, vitamin E, Sodium Hyaluronate, dexpanthenol, Hydrolyzed Collagen, wheat gluten, fibroin, camomile extract, xanthan gum, sodium alginate, glycerol, 1,3-BDO, disodium ethylene diamine tetraacetate, trehalose, ethoxy urea, deionized water and preservative.Preparation method of the present invention is simple, and emulsion process is not necessary to heat, and required cost is relatively low；Prepared good emulsion stability is capable of the activity of effective protection function factor, and particle diameter distribution is uniform, has preferable rheologic behavio(u)r and anti-oxidant, performance of keeping humidity.
Description
Technical field
The compound oil-in-water emulsion of xanthan gum/sodium alginate and its preparation side that the present invention relates to a kind of rich in function factor
Method belongs to facial treatment milk preparation field.
Background technique
The increase of wrinkle, the aging of skin are the results of free radical and radical reaction.After ultraviolet light penetrates skin, produce
Raw excessive free radical, will cause collagen and elastomer relaxation, fracture, and epidermal cell new life slows down；And nucleus can be because
By free radical injury and the cell of health can not be divided out, intercellular lipid also destroyed, and is unable to maintain that skin
Moisture, resulted in the aging of skin over time.One important channel of skin anti-aging is exactly using anti-oxidant and guarantor
Wet skin care item.
Nowadays anti-oxidant and moisturizing emulsion preparation has numerous reports.And vitamin E is a kind of common fat-soluble
Powerful antioxidant can help to eliminate free radical to free radical resisting lipid peroxidation, promote groups of cells after entering human body
Regeneration is knitted, has the function that anti-aging.But vitamin E is easily oxidized, if dealt with improperly, it is easy to lose effect.
In cosmetic industry, usually oil-in-water emulsion is selected to contain as carrier to it, prepare the cream containing function factor
Liquid.Oil-in-water emulsion is easy to be influenced by factors such as ionic strength, temperature, is easy to happen during long-term storage point
Layer, it is therefore desirable to develop available ingredient and means further increase the stability of emulsion product, and protect vitamin E etc.
The effective active of function factor.
Chinese patent literature CN105496864A discloses a kind of nutrition skin-protection lotion and preparation method thereof containing oat peptide
With application；The constituent of the nutrition skin-protection lotion are as follows: component A: oat peptide, methyl hydroxybenzoate, B component: water, aluminum magnesium silicate, C group
Point: butanediol, glycerol, propylene glycol, Sodium Hyaluronate, xanthan gum, D component: saualane, different ethylhexyl palmitate, poly- diformazan
Radical siloxane, Butylated Hydroxytoluene, Nipasol, cetostearyl alcohol, stearine, PEG-100 stearate, sucrose stearate
Ester, cetearyl glucoside, cetanol, vitamin E, camellia seed, component E: hydrolysis gadid lime-preserved egg is white, beet root extracts
Object, carboxymethylchitosan, preservative, essence；A, B, component C are uniformly mixed, D is added and mixes uniformly, adds E
Mix uniformly obtained facial treatment milk.The lotion has skin nutrition, crease-resistant, anti-aging effect；But raw materials used more, system
Preparation Method is cumbersome, and emulsion process required temperature is higher, higher cost；The surfactant of addition is more, larger to skin irritatin.
Chinese patent literature CN108294979A discloses a kind of moisturizing gel emulsion and preparation method thereof, the original of the moisturizing gel emulsion
Material includes: rose hip oil, Gotu Kola P.E, grape seed oil, vitamin E, isopropyl myristate, PEG-7 olive grease, ovum
Phosphatide, alkyl-glucoside, sodium alginate, 1,2-PD, water, stearyl alcohol, ethyl cellulose, stearoyl Sodium Hyaluronate,
Butanediol cocounut oil acid esters, methyl p-hydroxybenzoate, xanthan gum, xanthan gum, carbomer, citric acid；Preparation method is first will
Lotion is made in rose hip oil, Gotu Kola P.E, grape seed oil, vitamin E and PEG-7 olive grease, then adds water-setting
Gel matrix xanthan gum, xanthan gum and carbomer to obtain the final product.The invention has preferable moistening effect；But raw materials used more, emulsification
Process required temperature is higher, and homogenization pressure is larger, and preparation process time is long, higher cost；Also, due to the addition meeting of hydrogel
Destruction is generated to lotion, stability of emulsion is not good enough, and wherein effect of vitamin E etc. cannot be effectively protected.
Summary of the invention
In view of the deficienciess of the prior art, to provide a kind of xanthan gum/sodium alginate rich in function factor multiple by the present invention
Close oil-in-water emulsion and preparation method thereof.Preparation method of the present invention is simple, and emulsion process is not necessary to heat, and required cost is relatively low；Institute
The good emulsion stability of preparation is capable of the activity of effective protection function factor, and particle diameter distribution is uniform, has preferable rheological properties
It can be with anti-oxidant, performance of keeping humidity.
Technical scheme is as follows:
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
4~20 parts of oily phase, 1~5 part of emulsifier, 0.1~1 part of alcohol, 0.1~2 part of vitamin E, Sodium Hyaluronate 0.02~
1 part, 0.1~3 part of dexpanthenol, 0.1~3 part of Hydrolyzed Collagen, 0.1~3 part of wheat gluten, fibroin 0.1~3
Part, 0.1~3 part of camomile extract, 0.1~2 part of xanthan gum, 0.1~2 part of sodium alginate, 2~15 parts of glycerol, 1,3- fourth two
1~6 part of alcohol, 0.05~0.15 part of disodium ethylene diamine tetraacetate, 0.2~5 part of trehalose, 0.1~4 part of ethoxy urea, deionization
40~90 parts of water, 0.05~0.15 part of preservative.
It is preferred according to the present invention, the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, including
The raw material of following mass parts is made:
6~14 parts of oily phase, 1~3 part of emulsifier, 0.2~0.6 part of alcohol, 0.5~1.5 part of vitamin E, Sodium Hyaluronate
0.05~0.5 part, 0.3~2 part of dexpanthenol, 0.3~2 part of Hydrolyzed Collagen, 0.3~2 part of wheat gluten, silk egg
White 0.3~2 part, 0.3~1 part of camomile extract, 0.25~1 part of xanthan gum, 0.25~1 part of sodium alginate, glycerol 5~10
Part, 1~4 part of 1,3-BDO, 0.05~0.15 part of disodium ethylene diamine tetraacetate, 0.5~3 part of trehalose, ethoxy urea 0.3~
2 parts, 45~82 parts of deionized water, 0.05~0.15 part of preservative.
Preferred according to the present invention, the oil is mutually caprylic/capric triglyceride, olive oil, jojoba oil or nutmeg
The mixture of one or more of isopropyl propionate；The preferably mixture of caprylic/capric triglyceride and jojoba oil.
Preferred according to the present invention, the emulsifier is that Cremophor RH40, stearine or PEG-100 are sweet
The mixture of one or more of oleostearin acid esters；Preferably Cremophor RH40.
Preferred according to the present invention, the alcohol is cetostearyl alcohol；In cetostearyl alcohol containing 50%~70wt% ten
The hexadecanol of eight pure and mild 20%~35wt%.
Preferred according to the present invention, the granularity of the sodium alginate is 50~200 mesh.
Preferred according to the present invention, the preservative is methylparaben, Phenoxyethanol, Bis(hydroxymethyl)imidazolidinyl urea
Or one of imidazolidinyl urea；Preferably, the preservative is methylparaben.
Preferred according to the present invention, the mass ratio of the xanthan gum and sodium alginate is (2~4): 1；Xanthan gum and seaweed
The additional amount of sour sodium is respectively 0.24wt%~1.1wt% of oil-in-water emulsion quality.
Preferably, the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, including following mass parts
Raw material be made:
3~7 parts of caprylic/capric triglyceride, 3~7 parts of jojoba oil, 1~3 part of Cremophor RH40,16
Eight 0.2~0.6 part of alcohol, 0.5~1.5 part of vitamin E, 0.05~0.5 part of Sodium Hyaluronate, 0.3~2 part of dexpanthenol,
0.3~2 part of Hydrolyzed Collagen, 0.3~2 part of wheat gluten, 0.3~2 part of fibroin, 0.3~1 part of camomile extract,
0.25~1 part of xanthan gum, 0.25~1 part of sodium alginate, 5~10 parts of glycerol, 1~4 part of 1,3-BDO, ethylenediamine tetra-acetic acid two
0.05~0.15 part of sodium, 0.5~3 part of trehalose, 0.3~2 part of ethoxy urea, 45~82 parts of deionized water, methylparaben
0.05~0.15 part.
Optimal technical scheme of the present invention is as follows, the compound oil-in-water cream of the xanthan gum/sodium alginate rich in function factor
Liquid, the raw material including following mass parts are made:
4 parts of caprylic/capric triglyceride, 3 parts of jojoba oil, 1 part of Cremophor RH40,0.4 part of cetostearyl alcohol,
1 part of vitamin E, 0.1 part of Sodium Hyaluronate, 0.5 part of dexpanthenol, 0.5 part of Hydrolyzed Collagen, 0.5 part of wheat gluten,
0.5 part of fibroin, 0.5 part of camomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 1,3-BDO 2
Part, 0.1 part of disodium ethylene diamine tetraacetate (EDETATE SODIUM), 1 part of trehalose, 0.5 part of ethoxy urea, 75.8 parts of deionized water, Buddhist nun
0.1 part of tortoise beetle ester of pool.
Another kind optimal technical scheme of the invention is as follows, the xanthan gum rich in the function factor/sodium alginate Compound Water
Packet fat liquor, the raw material including following mass parts are made:
4 parts of caprylic/capric triglyceride, 3 parts of jojoba oil, 1.5 parts of Cremophor RH40, cetostearyl alcohol 0.4
Part, 1 part of vitamin E, 0.1 part of Sodium Hyaluronate, 0.5 part of dexpanthenol, 0.5 part of Hydrolyzed Collagen, wheat gluten 0.5
Part, 0.5 part of fibroin, 0.5 part of camomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 1,3-BDO
2 parts, 0.1 part of disodium ethylene diamine tetraacetate (EDETATE SODIUM), 1 part of trehalose, 0.5 part of ethoxy urea, 75.3 parts of deionized water, Buddhist nun
0.1 part of tortoise beetle ester of pool.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
(1) oily phase, emulsifier, pure and mild vitamin E are sufficiently mixed uniform oil-phase solution；
(2) Sodium Hyaluronate, dexpanthenol, Hydrolyzed Collagen, wheat gluten, fibroin, chamomile are extracted
Object, xanthan gum, sodium alginate, glycerol, 1,3 butylene glycol, disodium ethylene diamine tetraacetate, trehalose and ethoxy urea be dissolved in from
Aqueous phase solution is obtained in sub- water；
(3) oil-phase solution is added in aqueous phase solution, it is emulsified that condition is stirred at room temperature；Then preservative, room is added
Temperature stirring 1~2 hour, obtains the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor.
Preferred according to the present invention, in step (3), the emulsification times are 20~40min；Speed of agitator is 1000~
6000rpm。
Technical characterstic of the invention and the utility model has the advantages that
1, xanthan gum is a kind of non-adsorbent water-soluble macromolecule, can be used as thickener and stabilizer；Because xanthan gum is water-soluble
Liquid is a kind of pseudoplastic fluid, therefore the addition of xanthan gum of the present invention can assign lotion good shear shinning.Alginic acid
Sodium is a kind of natural polysaccharide substance, is not only common cosmetics thickener, stabilizer, and have good gas permeability and suction
Wet, moisturizing, bacteria resistance function.Xanthan gum and sodium alginate is added in the present invention in lotion, and the two plays synergistic effect, can be in O/
W droplet surface forms a boundary layer, improves the intensity of boundary layer, so as to enhance emulsion intercalation method, effective protection dimension
The activity of the function factors such as raw element E；And make lotion that there is good rheologic behavio(u)r, it is conducive to lotion skin care application；It can also be into one
Step improves the moisture retention and antibiotic property of lotion, reduces the use of expensive the moisture-keeping functions factor and preservative, reduces the same of cost
The safety of Shi Tigao product.
2, present invention preferably uses emulsifier be Cremophor RH40, the emulsifier have lower irritation and
The dispersion of the function factors such as vitamin E in water may be implemented in good solubilising, forms oil-in-water emulsion.It is used simultaneously
Xanthan gum and sodium alginate, the two synergistic effect, O/W droplet surface formed polymer interface layer, improve oil-water interfaces layer
Intensity contains lotion effectively for a long time to the realization of the function factors ingredient such as vitamin E, reduces dimension life during storage
The oxidation consumption of plain E etc. makes have preferable antioxidant effect in lotion use process.EDETATE SODIUM work is additionally added in the present invention
For chelating agent, emulsion intercalation method can be improved to avoid the chelation of metal ion in sodium alginate and lotion.In the present invention
The Sodium Hyaluronate and sodium alginate used all has good film forming, can form the moisturizing uniformly breathed freely in skin surface
Layer, on molecule a large amount of hydroxyl can effective bound water molecule, reduce the loss of moisture.Furthermore the jojoba oil selected has
Good inoxidizability and outstanding penetrating power, can penetrate into inside skin, and directly supplement cell metabolism needs
Nutrient, enhance the elasticity and moisture-retaining capacity of skin.
3, preparation method of the present invention is simple, and emulsion process is not necessary to heat, and operating process is easy to control, and cost is relatively low.The present invention
Each component is not independent from each other and plays a role in lotion, but the interaction that influences each other, and makes gained emulsion particle diameter distribution
Uniformly, stability is good, is capable of the activity of effective protection function factor, makes it have preferable rheologic behavio(u)r and anti-oxidant moisturizing
Performance.
Detailed description of the invention
Fig. 1 is the optical microscope of oil-in-water emulsion prepared by embodiment 3.
Fig. 2 is viscosity-shear rate relational graph of oil-in-water emulsion prepared by embodiment 3.
Fig. 3 be embodiment 3 prepare oil-in-water emulsion it is not chilled at -18 DEG C stored frozen and thaw after photo
Comparison diagram.
Specific embodiment
Technical scheme is described further combined with specific embodiments below.
Test method described in embodiment is conventional method unless otherwise instructed；Agents useful for same and raw material such as nothing are especially said
Bright is commercially available acquisition.
In embodiment, jojoba oil used, Guangzhou An Pin Chemical Co., Ltd. is on sale；Cremophor RH40, mountain
Dong You rope Chemical Industry Science Co., Ltd is on sale；Sodium Hyaluronate, Shandong Fu Ruida company are on sale；Hydrolyzed Collagen, wheat egg
White, fibroin, camomile extract, Huzhou Jiamei Biochemical Products Co., Ltd. is on sale；Sodium alginate, Qingdao bright moon sea
Algae company is on sale, viscosity 500cps, and granularity is 100 mesh；Cetostearyl alcohol, Guangzhou Sui Xin Chemical Co., Ltd. are on sale.
Embodiment 1
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 4g, jojoba oil 3g, Cremophor RH40 1g, cetostearyl alcohol 0.4g, dimension life
Plain E 1g, Sodium Hyaluronate 0.1g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, fibroin
0.5g, camomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, ethylenediamine tetra-acetic acid
Disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 75.8g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
By xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, EDETATE SODIUM 0.1g, Sodium Hyaluronate
0.1g, trehalose 1g, ethoxy urea 0.5g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk
Albumen 0.5g, camomile extract 0.5g are dissolved in 75.8g deionized water, are stirred 2 hours, are obtained aqueous phase solution；
By Cremophor RH40 1g, cetostearyl alcohol 0.4g, caprylic/capric triglyceride 4g, jojoba oil 3g, dimension
Raw element E 1g is mixed, and heating stirring obtains uniform oil-phase solution at 50 DEG C；
Under stirring conditions, oil is mutually slowly injected into water phase, emulsification 30 minutes is stirred at room temperature in 3000rpm；Finally plus
Enter methylparaben 0.1g, room temperature 1000rpm, which is stirred, obtains xanthan gum/sodium alginate Compound Water rich in function factor for 2 hours
Packet fat liquor.
Embodiment 2
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 4g, jojoba oil 3g, Cremophor RH40 1g, cetostearyl alcohol 0.4g, dimension life
Plain E 1g, Sodium Hyaluronate 0.1g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, fibroin
0.5g, camomile extract 0.5g, xanthan gum 1g, sodium alginate 0.25g, glycerol 6g, 1,3-BDO 2g, ethylenediamine tetra-acetic acid
Disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 76.05g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
By xanthan gum 1g, sodium alginate 0.25g, glycerol 6g, 1,3-BDO 2g, EDETATE SODIUM 0.1g, Sodium Hyaluronate
0.1g, trehalose 1g, ethoxy urea 0.5g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk
Albumen 0.5g, camomile extract 0.5g are dissolved in 76.05g deionized water, are stirred 2 hours, are obtained aqueous phase solution；
By Cremophor RH40 1g, cetostearyl alcohol 0.4g, caprylic/capric triglyceride 4g, jojoba oil 3g, dimension
Raw element E 1g is mixed, and heating stirring obtains uniform oil-phase solution at 50 DEG C；
Under stirring conditions, oil is mutually slowly injected into water phase, emulsification 30 minutes is stirred at room temperature in 3000rpm；Finally plus
Enter methylparaben 0.1g, 1000rpm, which is stirred at room temperature, obtains xanthan gum/sodium alginate Compound Water rich in function factor for 2 hours
Packet fat liquor.
Embodiment 3
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 4g, jojoba oil 3g, Cremophor RH40 1.5g, cetostearyl alcohol 0.4g, dimension
Raw element E 1g, Sodium Hyaluronate 0.1g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk egg
White 0.5g, camomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, ethylenediamine tetrem
Acid disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 75.3g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
By xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, EDETATE SODIUM 0.1g, Sodium Hyaluronate
0.1g, trehalose 1g, ethoxy urea 0.5g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk
Albumen 0.5g, camomile extract 0.5g are dissolved in 75.3g deionized water, are stirred 2 hours, are obtained aqueous phase solution；
By Cremophor RH40 1.5g, cetostearyl alcohol 0.4g, caprylic/capric triglyceride 4g, jojoba oil 3g,
Vitamin E 1g is mixed, and heating stirring obtains uniform oil-phase solution at 50 DEG C；
Under stirring conditions, oil is mutually slowly injected into water phase, emulsification 30 minutes is stirred at room temperature in 3000rpm；Finally plus
Enter methylparaben 0.1g, 1000rpm, which is stirred at room temperature, obtains xanthan gum/sodium alginate Compound Water rich in function factor for 2 hours
Packet fat liquor.
Fig. 1 is the optical microscope of oil-in-water emulsion manufactured in the present embodiment；As seen from the figure, gained emulsion particle diameter is distributed
Uniformly, particle size is 5 μm.
Fig. 2 is viscosity-shear rate relational graph of oil-in-water emulsion manufactured in the present embodiment；As seen from the figure, lotion is viscous
Degree is gradually reduced with the increase of shear rate, shows that obtained lotion has the property of good shear shinning.
Fig. 3 is the photo pair that oil-in-water emulsion manufactured in the present embodiment is not chilled and thaws again after -18 DEG C of freezings
Than figure；As seen from the figure, although freezing solidification after -18 DEG C of lotion warp freezings, restore to room temperature do not occur lamination,
Still for uniformly, the lotion of good fluidity, and after test is repeated several times, lotion is not all layered.
Embodiment 4
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 4g, jojoba oil 3g, Cremophor RH40 2g, cetostearyl alcohol 0.4g, dimension life
Plain E 1g, Sodium Hyaluronate 0.1g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, fibroin
0.5g, camomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, ethylenediamine tetra-acetic acid
Disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 74.8g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
By xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, EDETATE SODIUM 0.1g, Sodium Hyaluronate
0.1g, trehalose 1g, ethoxy urea 0.5g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk
Albumen 0.5g, camomile extract 0.5g are dissolved in 74.8g deionized water, are stirred 2 hours, are obtained aqueous phase solution；
By Cremophor RH40 2g, cetostearyl alcohol 0.4g, caprylic/capric triglyceride 4g, jojoba oil 3g, dimension
Raw element E 1g is mixed, and heating stirring obtains uniform oil-phase solution at 50 DEG C；
Under stirring conditions, oil is mutually slowly injected into water phase, emulsification 30 minutes is stirred at room temperature in 3000rpm；Finally plus
Enter methylparaben 0.1g, 1000rpm, which is stirred at room temperature, obtains xanthan gum/sodium alginate Compound Water rich in function factor for 2 hours
Packet fat liquor.
Embodiment 5
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 4g, jojoba oil 3g, Cremophor RH40 2g, cetostearyl alcohol 0.4g, dimension life
Plain E 1g, Sodium Hyaluronate 0.1g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, fibroin
0.5g, camomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, ethylenediamine tetra-acetic acid
Disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 74.8g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
By xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, EDETATE SODIUM 0.1g, Sodium Hyaluronate
0.1g, trehalose 1g, ethoxy urea 0.5g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk
Albumen 0.5g, camomile extract 0.5g are dissolved in 74.8g deionized water, are stirred 2 hours, are obtained aqueous phase solution；
By Cremophor RH40 2g, cetostearyl alcohol 0.4g, caprylic/capric triglyceride 4g, jojoba oil 3g, dimension
Raw element E 1g is mixed, and heating stirring obtains uniform oil-phase solution at 50 DEG C；
Under stirring conditions, oil is mutually slowly injected into water phase, emulsification 30 minutes is stirred at room temperature in 4000rpm；Finally plus
Enter methylparaben 0.1g, 1000rpm, which is stirred at room temperature, obtains xanthan gum/sodium alginate Compound Water rich in function factor for 2 hours
Packet fat liquor.
Embodiment 6
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 4g, jojoba oil 3g, Cremophor RH40 2g, cetostearyl alcohol 0.4g, dimension life
Plain E 1g, Sodium Hyaluronate 0.1g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, fibroin
0.5g, camomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, ethylenediamine tetra-acetic acid
Disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 74.8g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, comprising steps of
By xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1,3-BDO 2g, EDETATE SODIUM 0.1g, Sodium Hyaluronate
0.1g, trehalose 1g, ethoxy urea 0.5g, dexpanthenol 0.5g, Hydrolyzed Collagen 0.5g, wheat gluten 0.5g, silk
Albumen 0.5g, camomile extract 0.5g are dissolved in 74.8g deionized water, are stirred 2 hours, are obtained aqueous phase solution；
By Cremophor RH40 2g, cetostearyl alcohol 0.4g, caprylic/capric triglyceride 4g, jojoba oil 3g, dimension
Raw element E 1g is mixed, and heating stirring obtains uniform oil-phase solution at 50 DEG C；
Under stirring conditions, oil is mutually slowly injected into water phase, emulsification 30 minutes is stirred at room temperature in 6000rpm；Finally plus
Enter methylparaben 0.1g, 1000rpm, which is stirred at room temperature, obtains xanthan gum/sodium alginate Compound Water rich in function factor for 2 hours
Packet fat liquor.
Embodiment 7
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 3g, jojoba oil 5g, Cremophor RH40 3g, cetostearyl alcohol 0.2g, dimension life
Plain E 0.5g, Sodium Hyaluronate 0.05g, dexpanthenol 0.3g, Hydrolyzed Collagen 0.3g, wheat gluten 0.3g, silk egg
White 0.3g, camomile extract 0.3g, xanthan gum 0.25g, sodium alginate 1g, glycerol 5g, 1,3-BDO 1g, ethylenediamine tetrem
Acid disodium (EDETATE SODIUM) 0.1g, trehalose 1g, ethoxy urea 0.5g, deionized water 76.9g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor such as 1 institute of embodiment
It states.
Embodiment 8
A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts
It is made:
Caprylic/capric triglyceride 7g, jojoba oil 7g, Cremophor RH40 3g, cetostearyl alcohol 0.6g, dimension life
Plain E 1.5g, Sodium Hyaluronate 0.5g, dexpanthenol 2g, Hydrolyzed Collagen 2g, wheat gluten 2g, fibroin 2g, ocean
Flos Chrysanthemi extract 2g, xanthan gum 1g, sodium alginate 1g, glycerol 10g, 1,3-BDO 4g, disodium ethylene diamine tetraacetate (EDTA bis-
Sodium) 0.1g, trehalose 3g, ethoxy urea 2g, deionized water 48.3g, methylparaben 0.1g.
The preparation method of the above-mentioned compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor such as 1 institute of embodiment
It states.
Comparative example 1
A kind of oil-in-water emulsion, mass parts composition is as described in Example 1, except that: xanthan gum is not added；Other raw materials
And component is same as Example 1.
Preparation method and embodiment 1 are consistent.
Comparative example 2
A kind of oil-in-water emulsion, mass parts composition as described in Example 1, except that: xanthan gum additional amount be 0.1g,
Sodium alginate additional amount is 0.1g；Other raw materials and component are same as Example 1.
Preparation method and embodiment 1 are consistent.
Comparative example 3
A kind of oil-in-water emulsion, mass parts composition is as described in Example 1, except that: xanthan gum replaces with methyl fibre
Dimension element, additional amount 0.5g；Other raw materials and component are same as Example 1.
Preparation method and embodiment 1 are consistent.
Comparative example 4
A kind of oil-in-water emulsion, mass parts composition is as described in Example 1, except that: EDETATE SODIUM is not added；Other originals
Material and component are same as Example 1.
Preparation method and embodiment 1 are consistent.
Comparative example 5
A kind of oil-in-water emulsion, mass parts composition is as described in Example 3, except that: sodium alginate is not added；Other originals
Material and component are same as Example 3.
Preparation method and embodiment 3 are consistent.
Comparative example 6
A kind of oil-in-water emulsion, mass parts composition is as described in Example 3, except that: xanthan gum additional amount is 0.5g,
Sodium alginate additional amount is 0.1g；Other raw materials and component are same as Example 3.
Preparation method and embodiment 3 are consistent.
Comparative example 7
A kind of oil-in-water emulsion, mass parts composition is as described in Example 1, except that: sodium alginate additional amount is
0.1g；Other raw materials and component are same as Example 3.
Preparation method and embodiment 3 are consistent.
Test example 1
Resisted cold according to the oil-in-water emulsion that national standard GB/T 29665-2013 prepares embodiment 1 and comparative example 1-4,
The test of heat-resisting and centrifugal stability.
Test result is as follows shown in table 1, as shown in Table 1, the ratio of the addition of xanthan gum and xanthan gum and sodium alginate
Relationship has an important influence emulsion intercalation method.When not plus the quality of xanthan gum and xanthan gum and sodium alginate is smaller,
Although the lotion of preparation is by not stratified after centrifugation and under low temperature, heat-resistant stability is poor.EDTA bis- is not added
The lotion of sodium is placed at room temperature, is layered in the short time, cold-resistant, heat-resisting and centrifugal stability is bad, illustrates EDTA bis-
Sodium can improve emulsion intercalation method as chelating agent to avoid the chelation of metal ion in sodium alginate and lotion；It will be yellow
Virgin rubber replaces with methylcellulose, and gained lotion is cold-resistant, heat resistance is bad, illustrates the specific xanthan gum of the present invention for stability
Importance.
Table 1 is cold-resistant, heat-resisting and centrifugal stability test data
| Title | Low-temperature stability (- 4 DEG C) | High-temperature stability (50 DEG C) | Centrifugal stability (2000rpm 30min) |
| Embodiment 1 | It is not layered | It is not layered | It is not layered |
| Comparative example 1 | It is not layered | Layering | It is not layered |
| Comparative example 2 | It is not layered | Layering | It is not layered |
| Comparative example 3 | Layering | Layering | It is not layered |
| Comparative example 4 | Layering | Layering | Layering |
Test example 2
Using the back of the hand as test zone, select 10 people to comparative example 5-7, the resulting lotion of embodiment 3 and bought commodity cream
Liquid carries out performance of keeping humidity test.The selected instrument of moisture content of skin test is digital skin water content detection pen, skin when test
It surface cannot be with the presence of water.Tester's left hand smears lotion, and the right hand does not smear lotion；After tester washes hand 1min, survey
Moisture content is tried, as the skin moisture content before test, then left hand smears lotion, tests right-hand man's hand after 4 hours respectively
Carry on the back skin moisture content.Three different locations are taken to carry out test skin moisture content every time, test result is expressed as a percentage, and ten
People's test result is averaged.
Test result is as shown in table 2, and as seen from table, the sodium alginate being added in embodiment 3 is 0.5wt%, after 4 hours
The left hand moisture content of skin for being coated with lotion is obviously higher than not smearing the right hand of lotion, and the test than being coated with commercial emulsion
The water content of skin area is also high；Lotion obtained by comparative example 5-7, the skin moisture content after 4 hours is significantly lower than embodiment 3
Test result.This shows that the addition of sodium alginate and its additional amount and the ratio of xanthan gum influence the moistening effect of lotion, one
Quantitative sodium alginate, so that the performance of keeping humidity of lotion is preferable；Simultaneously when the large percentage of xanthan gum, lotion has larger viscous
Degree, moisture not easily run off, and lotion has preferable moistening effect.
2 moisture retention test data of table
Claims (10)
1. a kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, which is characterized in that including following quality
The raw material of part is made:
4~20 parts of oily phase, 1~5 part of emulsifier, 0.1~1 part of alcohol, 0.1~2 part of vitamin E, 0.02~1 part of Sodium Hyaluronate,
0.1~3 part of dexpanthenol, 0.1~3 part of Hydrolyzed Collagen, 0.1~3 part of wheat gluten, 0.1~3 part of fibroin, ocean
0.1~3 part of Flos Chrysanthemi extract, 0.1~2 part of xanthan gum, 0.1~2 part of sodium alginate, 2~15 parts of glycerol, 1,3-BDO 1~6
Part, 0.05~0.15 part of disodium ethylene diamine tetraacetate, 0.2~5 part of trehalose, 0.1~4 part of ethoxy urea, deionized water 40~
90 parts, 0.05~0.15 part of preservative.
2. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In the raw material including following mass parts is made:
6~14 parts of oily phase, 1~3 part of emulsifier, 0.2~0.6 part of alcohol, 0.5~1.5 part of vitamin E, Sodium Hyaluronate 0.05~
0.5 part, 0.3~2 part of dexpanthenol, 0.3~2 part of Hydrolyzed Collagen, 0.3~2 part of wheat gluten, fibroin 0.3~
2 parts, 0.3~1 part of camomile extract, 0.25~1 part of xanthan gum, 0.25~1 part of sodium alginate, 5~10 parts of glycerol, 1,3- fourth
1~4 part of glycol, 0.05~0.15 part of disodium ethylene diamine tetraacetate, 0.5~3 part of trehalose, 0.3~2 part of ethoxy urea, go from
45~82 parts of sub- water, 0.05~0.15 part of preservative.
3. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In the oil is mutually one or both of caprylic/capric triglyceride, olive oil, jojoba oil or isopropyl myristate
Above mixture；The preferably mixture of caprylic/capric triglyceride and jojoba oil.
4. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In including one or more in the following conditions:
A, the emulsifier is one of Cremophor RH40, stearine or PEG-100 stearine
Or two or more mixture；Preferably Cremophor RH40；
B, the alcohol is cetostearyl alcohol；Octadecyl alcolol and 20%~35wt% in cetostearyl alcohol containing 50%~70wt%
Hexadecanol；
C, the granularity of the sodium alginate is 50~200 mesh；
D, the preservative is one in methylparaben, Phenoxyethanol, Bis(hydroxymethyl)imidazolidinyl urea or imidazolidinyl urea
Kind；Preferably, the preservative is methylparaben.
5. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In the mass ratio of the xanthan gum and sodium alginate is (2~4): 1；The additional amount of xanthan gum and sodium alginate is respectively water packet
0.24wt%~1.1wt% of fat liquor quality.
6. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts is made:
3~7 parts of caprylic/capric triglyceride, 3~7 parts of jojoba oil, 1~3 part of Cremophor RH40, cetostearyl alcohol
0.2~0.6 part, 0.5~1.5 part of vitamin E, 0.05~0.5 part of Sodium Hyaluronate, 0.3~2 part of dexpanthenol, hydrolysis
0.3~2 part of collagen, 0.3~2 part of wheat gluten, 0.3~2 part of fibroin, 0.3~1 part of camomile extract, xanthan
0.25~1 part of glue, 0.25~1 part of sodium alginate, 5~10 parts of glycerol, 1~4 part of 1,3-BDO, disodium ethylene diamine tetraacetate
0.05~0.15 part, 0.5~3 part of trehalose, 0.3~2 part of ethoxy urea, 45~82 parts of deionized water, methylparaben 0.05
~0.15 part.
7. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts is made:
4 parts of caprylic/capric triglyceride, 3 parts of jojoba oil, 1 part of Cremophor RH40,0.4 part of cetostearyl alcohol, dimension life
It is E1 parts plain, 0.1 part of Sodium Hyaluronate, 0.5 part of dexpanthenol, 0.5 part of Hydrolyzed Collagen, 0.5 part of wheat gluten, silk
0.5 part of albumen, 0.5 part of camomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 2 parts of 1,3-BDO, second
0.1 part of edetate disodium (EDETATE SODIUM), 1 part of trehalose, 0.5 part of ethoxy urea, 75.8 parts of deionized water, Metagin
0.1 part of ester.
8. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists
In the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts is made:
4 parts of caprylic/capric triglyceride, 3 parts of jojoba oil, 1.5 parts of Cremophor RH40,0.4 part of cetostearyl alcohol, dimension
Raw E1 parts of element, 0.1 part of Sodium Hyaluronate, 0.5 part of dexpanthenol, 0.5 part of Hydrolyzed Collagen, 0.5 part of wheat gluten, silkworm
0.5 part of silk-fibroin, 0.5 part of camomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 2 parts of 1,3-BDO,
0.1 part of disodium ethylene diamine tetraacetate (EDETATE SODIUM), 1 part of trehalose, 0.5 part of ethoxy urea, 75.3 parts of deionized water, nipalgin
0.1 part of methyl esters.
9. the compound oil-in-water emulsion of xanthan gum/sodium alginate as described in claim 1-8 any one rich in function factor
Preparation method, comprising steps of
(1) oily phase, emulsifier, pure and mild vitamin E are sufficiently mixed uniform oil-phase solution；
(2) by Sodium Hyaluronate, dexpanthenol, Hydrolyzed Collagen, wheat gluten, fibroin, camomile extract, Huang
Virgin rubber, sodium alginate, glycerol, 1,3 butylene glycol, disodium ethylene diamine tetraacetate, trehalose and ethoxy urea are dissolved in deionized water
Obtain aqueous phase solution；
(3) oil-phase solution is added in aqueous phase solution, it is emulsified that condition is stirred at room temperature；Then preservative is added, room temperature is stirred
It mixes 1~2 hour, obtains the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor.
10. the preparation side of the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor according to claim 9
Method, which is characterized in that in step (3), the emulsification times are 20~40min；Speed of agitator is 1000~6000rpm.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110547455A (en) * | 2019-09-02 | 2019-12-10 | 嘉必优生物技术（武汉）股份有限公司 | Microcapsule containing sialic acid and carotenoid and preparation method and application thereof |
| CN111603395A (en) * | 2020-05-27 | 2020-09-01 | 山东大学 | Whitening and moisturizing emulsion containing lamellar liquid crystal and preparation method thereof |
| CN111603395B (en) * | 2020-05-27 | 2022-04-08 | 山东大学 | Whitening and moisturizing emulsion containing lamellar liquid crystal and preparation method thereof |
| CN111743848A (en) * | 2020-06-28 | 2020-10-09 | 西安文理学院 | Anti-aging mask containing pilose antler and preparation method thereof |
| CN113144220A (en) * | 2021-04-30 | 2021-07-23 | 中国药科大学 | Beta-cyclodextrin inclusion compound, gel preparation, preparation method and application thereof |
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