CN112353705B

CN112353705B - Cosmetic composition, preparation method thereof and cosmetic with wrinkle removing and aging delaying effects

Info

Publication number: CN112353705B
Application number: CN202011345269.5A
Authority: CN
Inventors: 聂艳峰; 郭朝万; 许腾云; 胡露; 陈杰; 肖湲
Original assignee: Guangdong Marubi Biological Technology Co Ltd
Current assignee: Guangdong Marubi Biological Technology Co Ltd
Priority date: 2020-11-25
Filing date: 2020-11-25
Publication date: 2023-06-30
Anticipated expiration: 2040-11-25
Also published as: CN112353705A

Abstract

The invention provides a cosmetic composition, a preparation method thereof and a cosmetic with the effects of removing wrinkles and delaying aging, and relates to the technical field of cosmetics. The cosmetic composition is mainly prepared from astaxanthin, dipeptide diamino Ding Xianbian-base amide diacetate, acetyl tetrapeptide-2, an antioxidant, water and the like, wherein the astaxanthin, the dipeptide diamino Ding Xianbian-base amide diacetate and the acetyl tetrapeptide-2 serve as main functional components of the cosmetic composition, have synergistic interaction, and can achieve the effects of removing wrinkles and delaying aging; an Fu rutin and butylhydroxytoluene are used as antioxidants to effectively prevent discoloration of the cosmetic composition due to instability of astaxanthin, thereby improving stability of the cosmetic composition. The invention also provides a preparation method of the cosmetic composition.

Description

Cosmetic composition, preparation method thereof and cosmetic with wrinkle removing and aging delaying effects

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition, a preparation method thereof and a cosmetic with the effects of removing wrinkles and delaying aging.

Background

The astaxanthin is formed by connecting 4 isoprene double bonds end to end, and has 11 conjugated double bonds, and beta-ionone ring structure composed of 2 isoprene units at two ends, and has a molecular formula of C ₄₀ H ₅₂ O ₄ The relative molecular weight of the polymer is 596.86,is a ketone carotenoid. Because astaxanthin has strong antioxidant function, can remove free radicals in vivo, strengthen host immunity, inhibit tumor generation, delay aging and other biological functions, the astaxanthin is widely applied to the fields of cosmetics and the like.

However, astaxanthin is a long-chain unsaturated double bond structure system, so that the astaxanthin is unstable in property and easy to isomerize and degrade. Astaxanthin is sensitive to oxygen, sunlight and ultraviolet irradiation, and temperature, and the isomerization of astaxanthin and thus the discoloration of the product can be caused by heat treatment, meta-acid or alkaline conditions and the like. Therefore, how to improve the stability of astaxanthin products and make the products not easy to change color is one of the problems to be solved in the field.

In view of the above, the present invention has been made to solve at least one of the above-mentioned technical problems.

Disclosure of Invention

The first aim of the invention is to provide a cosmetic composition which has good stability, is not easy to change color, and has obvious effects of removing wrinkles and delaying aging on skin.

A second object of the present invention is to provide a method for preparing a cosmetic composition.

The third purpose of the invention is to provide a cosmetic with the efficacy of removing wrinkles and delaying aging.

In order to achieve the above purpose, the invention adopts the following technical scheme:

the invention provides a cosmetic composition, which comprises the following raw materials in parts by mass:

0.05-1% of astaxanthin, 0.05-2% of dipeptide diamino Ding Xianbian-base amide diacetate, 0.05-2% of acetyl tetrapeptide-2, 0.25-0.7% of antioxidant and the balance of water to 100%;

wherein the antioxidant comprises rutin for caring skin and butylhydroxytoluene.

Furthermore, on the basis of the technical scheme, the mass ratio of the amirutin to the butoxide toluene in the antioxidant is (0.05-0.2): (0.2-0.5);

optionally, the antioxidant further comprises tocopheryl acetate, and the mass ratio of the rutin, the butylhydroxytoluene and the tocopheryl acetate is (0.05-0.2): (0.2-0.5): (0.1-0.3).

Further, on the basis of the above technical solution of the present invention, the raw materials of the cosmetic composition further include any one or a combination of at least two of an emulsifier, an emollient, a humectant, a thickener, a skin conditioner, a chelating agent, a pH adjustor or a preservative;

optionally, the cosmetic composition further comprises an emulsifier, an emollient, a humectant, a thickener, a skin conditioner, a chelating agent, an emulsifier, a pH regulator and a preservative.

Further, on the basis of the technical scheme of the invention, the mass fraction of the emulsifier is 1.77-5.64%;

optionally, the emulsifier comprises any one or a combination of at least two of C14-22 alcohol, C12-20 alkyl glucoside, glycerol stearate, PEG-100 stearate or PPG-5-laureth-5;

optionally, the mass fraction of the emollient is 2.6-14.0%;

optionally, the emollient comprises any one or a combination of at least two of caprylic/capric triglyceride, ethylhexyl palmitate, squalane, or polydimethylsiloxane;

optionally, the mass fraction of the humectant is 9.0-26.0%;

optionally, the humectant comprises any one or a combination of at least two of glycerin, butylene glycol or propylene glycol;

optionally, the mass fraction of the thickener is 0.1-0.5%;

optionally, the thickener comprises acrylic acid (esters) of C10-30 alkanol acrylate cross-linked polymers and/or carbomers;

optionally, the skin conditioning agent has a mass fraction of 0.25-1.5%;

optionally, the skin conditioning agent comprises dipotassium glycyrrhizinate and/or allantoin;

optionally, the mass fraction of the chelating agent is 0.02-0.20%;

optionally, the chelating agent comprises disodium EDTA;

optionally, the mass fraction of the pH regulator is 0.03-0.20%;

optionally, the pH adjuster comprises aminomethylpropanol;

optionally, the mass fraction of the preservative is 0.45-0.80%;

optionally, the preservative comprises methylparaben and/or phenoxyethanol.

Further, on the basis of the technical scheme, the cosmetic composition comprises the following raw materials in percentage by mass:

0.05 to 1 percent of astaxanthin, 0.05 to 2.0 percent of dipeptide diamino Ding Xianbian-based amide diacetate, 0.05 to 2 percent of acetyl tetrapeptide-2, 0.25 to 0.70 percent of antioxidant, 1.77 to 5.64 percent of emulsifier, 2.6 to 14.0 percent of emollient, 9.0 to 26.0 percent of humectant, 0.1 to 0.5 percent of thickener, 0.25 to 1.50 percent of skin conditioner, 0.02 to 0.20 percent of chelating agent, 0.03 to 0.20 percent of pH regulator, 0.45 to 0.80 percent of preservative, and the balance of water to 100 percent;

0.05 to 1 percent of astaxanthin, 0.05 to 2.0 percent of dipeptide diamino Ding Xianbian-based amide diacetate, 0.05 to 2.2 percent of acetyl tetrapeptide-2, 0.25 to 0.70 percent of antioxidant, 0.8 to 2.5 percent of C14-22 alcohol, 0.2 to 1 percent of C12-20 alkyl glucoside, 0.2 to 0.6 percent of glycerol stearate, 0.1 to 0.5 percent of PEG-100 stearate, 0.3 to 0.6 percent of sodium polyacrylate, 0.15 to 0.40 percent of hydrogenated polydecene, 0.02 to 0.04 percent of PPG-5-laureth, 1 to 5 percent of caprylic/capric triglyceride, 1 to 5 percent of ethylhexyl palmitate, 0.1 to 1.0 percent of squalane, 0.5 to 3.0 percent of polydimethyl siloxane, 5 to 10 percent of glycerol, 2 to 8 percent of butanediol, 2 to 8 percent of propanediol, 0.05 to 0.30 percent of acrylic acid/C10-30 alkanol acrylate cross-linked polymer, 0.05 to 0.20 percent of carbomer, 0.05 to 0.20 percent of potassium polyacrylate, 0.05 to 0.0.0.0 percent of sodium benzoate, 0.0.02 to 0.0.0.0.0.0 percent of sodium benzoate, and the balance of sodium benzoate, 0.0.0 to 0.0.0.0.0 percent of sodium benzoate.

The invention also provides a preparation method of the cosmetic composition, which comprises the following steps:

astaxanthin, dipeptide diamino Ding Xianbian-yl amide diacetate, acetyl tetrapeptide-2, an antioxidant, optionally an emulsifier, optionally an emollient, optionally a humectant, optionally a thickener, optionally a skin conditioner, optionally a chelating agent, optionally a pH adjustor, optionally a preservative, and water are mixed to obtain a cosmetic composition.

Further, on the basis of the technical scheme of the invention, the preparation method comprises the following steps:

(a) Providing a component A formed by mixing C14-22 alcohol, C12-20 alkyl glucoside, glycerol stearate, PEG-100 stearate, caprylic/capric triglyceride, ethylhexyl palmitate, squalane, polydimethylsiloxane and butylhydroxytoluene;

(b) Providing a component B formed by mixing glycerol, dipotassium glycyrrhizinate, disodium EDTA, butanediol, propylene glycol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, carbomer, allantoin and methylparaben;

(c) Providing a C component formed by mixing sodium polyacrylate, hydrogenated polydecene and PPG-5-laureth-5;

(d) Providing a D component formed by mixing astaxanthin, dipeptide diamino Ding Xianbian-base amide diacetate, acetyl tetrapeptide-2, amirutin and phenoxyethanol;

(e) Mixing the component A and the component B for primary homogenization, adding the component C for secondary homogenization, adding the aminomethyl propanol and water for mixing, and then adding the component D to obtain the cosmetic composition.

Further, on the basis of the technical scheme, in the step (a), the mixing temperature is 82 ℃;

optionally, in step (b), the temperature of mixing is 85 ℃;

optionally, in step (e), the time of one homogenization is 2min and the rotation speed is 9000rpm;

optionally, in step (e), the time of the secondary homogenization is 1min and the rotation speed is 9000rpm.

The invention also provides a cosmetic with the effects of removing wrinkles and delaying aging, which comprises the cosmetic composition.

Compared with the prior art, the invention has the beneficial effects that:

(1) The invention provides a cosmetic composition, which is mainly prepared from astaxanthin, dipeptide diamino Ding Xianbian-base amide diacetate, acetyl tetrapeptide-2, an antioxidant, water and the like, wherein the astaxanthin, the dipeptide diamino Ding Xianbian-base amide diacetate and the acetyl tetrapeptide-2 are used as main efficacy components of the cosmetic composition, have synergistic interaction, and can achieve the effects of removing wrinkles and delaying aging; an Fu rutin and butylhydroxytoluene are used as antioxidants to effectively prevent discoloration of the cosmetic composition due to instability of astaxanthin, thereby improving stability of the cosmetic composition.

(2) The invention provides a preparation method of a cosmetic composition, which has simple process and easy operation and is suitable for mass production. The cosmetic composition prepared by the method has good compatibility and stability among the raw materials.

(3) The invention provides a cosmetic with the effects of removing wrinkles and delaying aging, which comprises the cosmetic composition. In view of the advantages of the cosmetic composition, the cosmetic with the effects of removing wrinkles and delaying aging has the same advantages.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a comparison of wrinkles before and after 8 weeks of subject 1 using the cosmetic composition of example 10;

FIG. 2 is a comparison of wrinkles before and after 8 weeks of use of the cosmetic composition of example 10 in subject 2;

FIG. 3 is a comparison of subject 2 before and after 8 weeks of use of the cosmetic composition of example 10;

FIG. 4 is a visual-CR picture of subject 2 after 8 weeks of use of the cosmetic composition of example 10.

Detailed Description

The technical solutions of the present invention will be clearly and completely described in connection with the embodiments, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

According to a first aspect of the present invention, there is provided a cosmetic composition comprising the following raw materials in mass fraction:

wherein the antioxidant comprises rutin and butylhydroxytoluene.

Specifically, astaxanthin has strong antioxidation function, can remove free radicals in the body, and delays skin aging. Typical but non-limiting astaxanthin mass fractions are 0.05%, 0.08%, 0.1%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8% or 1.0%.

Dipeptide diamino Ding Xianbian-yl amid diacetate is a small peptide which simulates the activity of the snake venom Waglein I, can prevent the nerve conduction of acetylcholine and achieve the effect of relaxing muscles, thereby improving dynamic wrinkles. Typical but non-limiting mass fractions of dipeptide diamino Ding Xianbian-based amide diacetate are 0.05%, 0.08%, 0.1%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8%, 1.0%, 1.2%, 1.5%, 1.8% or 2%.

Acetyl tetrapeptide-2 can activate FBLN5 and LOXL1 promoters, improve the level of the two proteins, induce elastin synthesis, strengthen skin firmness, reconstruct dermis structure, have the effect of tightening skin, and simultaneously can remodel facial contours, and have the lifting effect. Typical, but non-limiting, mass fractions of acetyl tetrapeptide-2 are 0.05%, 0.08%, 0.1%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8%, 1.0%, 1.2%, 1.5%, 1.8% or 2%.

Astaxanthin, dipeptide diamino Ding Xianbian-yl amide diacetate and acetyl tetrapeptide-2 are used as main functional components of the cosmetic composition, and have synergistic effects, and have the effects of removing wrinkles and delaying aging. Dipeptide diamino Ding Xianbian-yl amidic diacetate is a neurotransmitter peptide, which can make muscles unable to effectively accept neurotransmitters, and muscle contraction is limited, while astaxanthin can cross cell membrane bilayers, scavenge oxygen free radicals in cells, and supplement collagen and elastin through acetyl tetrapeptide-2, thereby preventing skin aging and wrinkles.

Since astaxanthin in a cosmetic composition is unstable in nature and easily causes discoloration of a cosmetic composition product, an antioxidant is required to be added to prevent discoloration thereof, thereby improving stability thereof. The antioxidant is typically, but not limited to, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.55%, 0.6%, 0.65% or 0.7% by mass.

The oxidant in the invention comprises the skin-soothing rutin and the butylhydroxytoluene.

An Fu rutin has strong oxidation resistance and UVB absorption capacity, can resist ultraviolet injury, inhibit oxidation and glycosylation, and can effectively remove oxygen free radicals in cells.

The butylated hydroxytoluene is a common grease antioxidant and can effectively delay the oxidative rancidity of grease.

An Fu rutin and butylhydroxytoluene are combined to jointly act as an antioxidant.

The term "comprising" as used herein means that it may include, in addition to the materials described, other materials acceptable in the cosmetic field, such as thickeners, humectants, and the like, which impart different characteristics to the cosmetic composition. In addition, the "including" of the present invention may be replaced by "being" or "made of … …" which are closed.

In addition, it should be noted that the balance of water is the balance of water excluding astaxanthin, dipeptidyl diamino Ding Xianbian-based amide diacetate, acetyl tetrapeptide-2, antioxidants and optionally other materials in the raw materials of the cosmetic composition of the present invention, and the sum of the water and the astaxanthin, dipeptidyl diamino Ding Xianbian-based amide diacetate, acetyl tetrapeptide-2, antioxidants and optionally other materials is 100% by mass.

As an alternative embodiment of the invention, the mass ratio of the amirutin to the butyoxytoluene in the antioxidant is (0.05-0.2): (0.2-0.5). An Fu the typical but non-limiting mass ratio of rutin to butylhydroxytoluene is 0.05:0.2, 0.05:0.3, 0.05:0.4, 0.05:0.5, 0.1:0.2, 0.15:0.2, 0.2:0.2, 0.1:0.3, 0.15:0.3, 0.2:0.3, 0.1:0.4, 0.15:0.4, 0.2:0.4, 0.1:0.5, 0.15:0.5 or 0.2:0.5.

as an alternative embodiment of the present invention, the antioxidant further comprises tocopheryl acetate, and the mass ratio of the rutin, the butylated hydroxytoluene and the tocopheryl acetate is (0.05-0.2): (0.2-0.5): (0.1-0.3).

Tocopheryl acetate has strong reducibility and can be used as an antioxidant. Meanwhile, the skin conditioner also has the functions of resisting oxidization and further preventing aging in the metabolism process of a human body, and can keep the normal function of the skin.

Typical but non-limiting mass ratios of rutin, butylated hydroxytoluene and tocopheryl acetate are.

The cosmetic composition can comprise astaxanthin, dipeptide diamino Ding Xianbian-base amide diacetate, acetyl tetrapeptide-2, antioxidant and water, and can also comprise other components acceptable in the cosmetic field, such as thickener, humectant, etc.

As an alternative embodiment of the present invention, the raw materials of the cosmetic composition further include any one or a combination of at least two of an emulsifier, an emollient, a humectant, a thickener, a skin conditioning agent, a chelating agent, a pH adjuster, or a preservative.

As a preferred embodiment of the present invention, the raw materials of the cosmetic composition further include an emulsifier, an emollient, a humectant, a thickener, a skin conditioner, a chelating agent, an emulsifier, a pH adjuster, and a preservative.

The emulsifier is a substance with surface activity and has the characteristics of hydrophilic group and lipophilic group in molecules, so that water and oil can be mixed with each other after the emulsifier is added in an oil-water system, oil-water separation is prevented, and the effect of stabilizing the product performance is achieved. As an alternative embodiment of the invention, the mass fraction of the emulsifier is 1.77-5.64%; typical, but non-limiting, mass fractions of emulsifiers are 1.77%, 1.80%, 2.00%, 2.20%, 2.50%, 2.80%, 3.00%, 3.20%, 3.50%, 3.80%, 4.00%, 4.20%, 4.50%, 4.80%, 5.00%, 5.20%, 5.50% or 5.64%.

As an alternative embodiment of the invention, the emulsifier comprises any one or a combination of at least two of C14-22 alcohol, C12-20 alkyl glucoside, glyceryl stearate, PEG-100 stearate, or PPG-5-laureth-5.

Wherein the C14-22 alcohol refers to an alcohol substance with 14-22 carbon atoms. C12-20 alkyl glucosides are substances synthesized from natural fatty alcohols with carbon chain lengths of 12-20 and glucose.

The emollient is a substance which has the functions of moisturizing, moistening, protecting, regulating and transforming human skin in cosmetics, can improve the retention time of moisture in the skin and can influence the skin feel performance of a cosmetic formula, and the mass fraction of the emollient is 2.6-14.0 percent as an alternative embodiment of the invention; typical, but non-limiting, mass fractions of emollients are 2.6%, 2.8%, 3.0%, 3.5%, 4.0%, 4.5%, 5.0%, 5.5%, 5.8%, 6.0%, 7.5%, 8.0%, 8.5%, 9.0%, 10.5%, 11.0%, 11.5%, 12.0%, 12.5%, 13.0%, 13.5% or 14.0%.

Optionally, the emollient comprises any one or a combination of at least two of caprylic/capric triglyceride, ethylhexyl palmitate, squalane, or polydimethylsiloxane.

The moisturizing agent plays the moisturizing effect through the retention and absorption of moisture, and can effectively restore the skin elasticity. Thus, the moisturizer can absorb and retain moisture and maintain the skin barrier function while maintaining skin hydration. As an alternative embodiment of the invention, the mass fraction of the humectant is 9.0-26.0%; the humectant typically, but not limited to, is 9.0%, 10.5%, 11.0%, 11.5%, 12.0%, 12.5%, 13.0%, 13.5%, 14.0%, 14.5%, 15.0%, 15.5%, 16.0%, 16.5%, 17.0%, 17.5%, 18.0%, 19.0%, 20.0%, 21.0%, 22.0%, 23.0%, 24.0%, 25.0%, or 26.0% by mass.

Alternatively, the humectant comprises any one or a combination of at least two of glycerin, butylene glycol or propylene glycol.

The thickener is a chemical auxiliary agent for increasing the consistency of cosmetics, has good compatibility, can improve the viscosity and stability of cosmetics, and has better emulsifying and suspending functions. As an alternative embodiment of the present invention, the thickener is 0.1-0.5% by mass; the thickener is typically, but not limited to, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45% or 0.5% by mass.

Optionally, the thickener comprises acrylic/C10-30 alkanol acrylate cross-linked polymers and/or carbomers. By "and/or" is meant herein that the thickener may comprise only acrylic/C10-30 alkanol acrylate cross-linked polymers, or only carbomers, or both acrylic/C10-30 alkanol acrylate cross-linked polymers and carbomers.

Skin conditioning agents are ingredients of cosmetics that act on the skin, i.e. the active of the cosmetic. The cosmetic has the effects of moisturizing, resisting aging and the like, and plays a practical role mainly through the added skin conditioner. As an alternative embodiment of the invention, the skin conditioning agent has a mass fraction of 0.25-1.5%; typical, but non-limiting, skin conditioning agents are 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4% or 1.5% by mass.

Optionally, the skin conditioning agent comprises dipotassium glycyrrhizinate and/or allantoin. By "and/or" herein is meant that the skin conditioning agent may comprise only dipotassium glycyrrhizinate, or only allantoin, or both dipotassium glycyrrhizinate and allantoin.

The chelating agent has the function of chelating metal ions in cosmetics, so that the stability of the product is maintained, the damage of harmful metal ions to skin is reduced, and in addition, the chelating agent has the function of corrosion prevention and synergism. As an alternative embodiment of the present invention, the mass fraction of chelating agent is 0.02-0.20%; the chelating agent is typically, but not limited to, 0.02%, 0.04%, 0.05%, 0.06%, 0.08%, 0.10%, 0.12%, 0.14%, 0.15%, 0.16%, 0.18% or 0.2% by mass.

Optionally, the chelating agent comprises disodium EDTA.

The pH regulator is an acidity regulator for maintaining the pH value of the cosmetic so that the pH value of the cosmetic approaches the pH value of the skin. As an alternative embodiment of the invention, the mass fraction of the pH regulator is 0.03-0.20%; the pH adjuster is typically, but not limited to, 0.03%, 0.04%, 0.05%, 0.06%, 0.08%, 0.10%, 0.12%, 0.14%, 0.15%, 0.16%, 0.18% or 0.2% by mass.

Optionally, the pH adjuster comprises aminomethylpropanol.

The preservative has the main functions of preventing the growth of microorganisms, protecting the product from being polluted by the microorganisms and prolonging the shelf life of the product; ensure the safety of the product and prevent the possible infection caused by the use of the product polluted by the microorganism. As an alternative embodiment of the invention, the mass fraction of the preservative is 0.45-0.80%; the preservative is typically, but not limited to, 0.45%, 0.5%, 0.55%, 0.60%, 0.65%, 0.7%, 0.75% or 0.80% by mass.

Optionally, the preservative comprises methylparaben and/or phenoxyethanol. By "and/or" herein is meant that the skin conditioning agent may comprise only methylparaben, or only phenoxyethanol, or both methylparaben and phenoxyethanol.

As an alternative embodiment of the present invention, a cosmetic composition comprises the following raw materials in mass fraction:

optionally, the cosmetic composition comprises the following raw materials in parts by mass:

By further limiting the types and the amounts of the raw materials in the cosmetic composition, the cosmetic composition has better stability and obvious effects of removing wrinkles and delaying aging of skin.

As an alternative embodiment of the invention, the cosmetic composition is in the form of a cream, emulsion, solution, film or spray (pump spray or aerosol), preferably a emulsion.

The cosmetic composition can be in the form of lotion, skin cream, essence, astringent, facial mask, spray water, facial cleanser or eye cream.

According to a second aspect of the present invention, there is also provided a method for preparing the above cosmetic composition, comprising the steps of:

The preparation method has simple process and easy operation, and is suitable for mass production. The cosmetic composition prepared by the method has good compatibility and stability among the raw materials.

As an alternative embodiment of the present invention, the method for preparing the above cosmetic composition comprises the steps of:

As an alternative embodiment of the present invention, in step (a), the temperature of mixing is 82 ℃;

optionally, in step (b), the temperature of mixing is 85 ℃;

By adopting different feeding, mixing sequences, heating and cooling temperatures and homogenizing parameters, the raw materials are mixed more uniformly, the compatibility among the raw materials is better, and the stability and uniformity of the cosmetic composition are improved.

According to a third aspect of the present invention, there is also provided a cosmetic having wrinkle-removing and aging-delaying effects, comprising the above cosmetic composition.

In view of the advantages of the cosmetic composition, the cosmetic with the effects of removing wrinkles and delaying aging has the same advantages.

The present invention will be further described with reference to specific examples and comparative examples.

Example 1

The embodiment provides a cosmetic composition, which comprises the following raw materials in percentage by mass:

astaxanthin 0.05%, dipeptide diamino Ding Xianbian-base amide diacetate 0.1%, acetyl tetrapeptide-2.1%, skin-care rutin 0.1%, butylhydroxytoluene 0.3%, and water for the rest to 100%;

the antioxidant comprises rutin and butylhydroxytoluene.

The preparation method of the cosmetic composition comprises the following steps:

astaxanthin, dipeptide diamino Ding Xianbian-yl amide diacetate, acetyl tetrapeptide-2, rutin, butylhydroxytoluene 0.3% and water were mixed to obtain cosmetic composition.

Example 2

astaxanthin 0.05%, dipeptide diamino Ding Xianbian-yl amide diacetate 0.1%, acetyl tetrapeptide-2.1%, antan 0.1%, butylhydroxytoluene 0.3%, C16 alcohol 1.2%, C18 alkyl glucoside 0.6%, glyceryl stearate 0.3%, PEG-100 stearate 0.2%, sodium polyacrylate 0.4%, hydrogenated polydecene 0.25%, PPG-5-laureth-5.03%, caprylic/capric triglyceride 3%, ethylhexyl palmitate 2.5%, squalane 0.5%, polydimethylsiloxane 2%, glycerol 6%, butylene glycol 5%, propylene glycol 4%, acrylic acid (esters) or C10-30 alkanol acrylate cross-linked polymer 0.15%, carbomer 0.1%, dipotassium glycyrrhizinate 0.2%, allantoin 0.2%, disodium EDTA disodium 0.05%, aminomethylpropanol 0.1%, hydroxybenzoyl ester 0.05%, phenoxyethanol 0.5%, and water balance to 100%.

(a) Mixing C16 alcohol, C18 alkyl glucoside, glycerol stearate, PEG-100 stearate, caprylic/capric triglyceride, ethylhexyl palmitate, squalane, polydimethylsiloxane and butylhydroxytoluene at 82 ℃ to obtain a component A;

(b) Mixing glycerol, dipotassium glycyrrhizinate, EDTA disodium, butanediol, propylene glycol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, carbomer, allantoin and methylparaben at 85deg.C to obtain component B;

(c) Mixing sodium polyacrylate, hydrogenated polydecene and PPG-5-laureth-5 to obtain a component C;

(d) Mixing astaxanthin, dipeptide diamino Ding Xianbian-yl amide diacetate, acetyl tetrapeptide-2, amirutin and phenoxyethanol to obtain a component D;

(e) Adding the component B into the component A for primary homogenization at 9000rpm for 2min, adding the component C for secondary homogenization at 9000rpm for 1min, cooling to 70deg.C, adding aminomethylpropanol and water, stirring, cooling to 45deg.C, and adding the component D to obtain the cosmetic composition.

Example 3

This example provides a cosmetic composition in which the amount of raw materials used was the same as in example 2, except that astaxanthin was 1% by mass.

The cosmetic composition was prepared in the same manner as in example 2.

Example 4

This example provides a cosmetic composition, which is the same as that of example 2 except that the raw materials of the cosmetic composition have a mass fraction of rutin for skin-soothing of 0.2%, and a mass fraction of toluene for butyl hydroxy of 0.2%.

The cosmetic composition was prepared in the same manner as in example 2.

Example 5

This example provides a cosmetic composition, which is the same as that of example 2 except that the raw materials of the cosmetic composition have a mass fraction of rutin for skin-soothing of 0.02%, a mass fraction of toluene for butyl hydroxy of 0.38%.

The cosmetic composition was prepared in the same manner as in example 2.

Example 6

This example provides a cosmetic composition comprising, in addition to the raw materials of the cosmetic composition, 0.2% by mass of tocopheryl acetate, the tocopheryl acetate being added in step (a) in the same amounts as in example 2.

Example 7

This example provides a cosmetic composition, and the amounts of the raw materials used are the same as in example 2, except that the mass fraction of dipeptide diamino Ding Xianbian-based amide diacetate in the raw materials of the cosmetic composition is 2%.

The cosmetic composition was prepared in the same manner as in example 2.

Example 8

This example provides a cosmetic composition, and the amounts of the raw materials used are the same as in example 2, except that the mass fraction of acetyl tetrapeptide-2 in the raw materials of the cosmetic composition is 2%.

The cosmetic composition was prepared in the same manner as in example 2.

Example 9

astaxanthin 0.5%, dipeptide diamino Ding Xianbian-amide diacetate 1%, acetyl tetrapeptide-2 1%, antan 0.05%, butylhydroxytoluene 0.5%, tocopheryl acetate 0.2%, C116 alcohol 1.2%, C18 alkyl glucoside 0.7%, glycerol stearate 0.4%, PEG-100 stearate 0.3%, sodium polyacrylate 0.3%, hydrogenated polydecene 0.25%, PPG-5-laureth-5.03%, caprylic/capric triglyceride 3%, ethylhexyl palmitate 2.5%, squalane 0.5%, polydimethylsiloxane 2%, glycerol 6%, butylene glycol 5%, propylene glycol 4%, acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.15%, carbomer 0.1%, dipotassium glycyrrhizinate 0.2%, allantoin 0.2%, disodium EDTA 0.08%, aminomethylpropanol 0.1%, oxybenzene methyl ester 0.08%, phenoxyethanol 0.5% and water with the balance to 100%.

The cosmetic composition was prepared in the same manner as in example 2.

Example 10

astaxanthin 0.2%, dipeptide diamino Ding Xianbian-ylamide diacetate 0.5%, acetyl tetrapeptide-2.8%, antan 0.15%, butylhydroxytoluene 0.3%, tocopheryl acetate 0.3%, C16 alcohol 1.2%, C18 alkyl glucoside 0.5%, glyceryl stearate 0.4%, PEG-100 stearate 0.2%, sodium polyacrylate 0.4%, hydrogenated polydecene 0.3%, PPG-5-laureth-5.04%, caprylic/capric triglyceride 3%, ethylhexyl palmitate 2.5%, squalane 0.5%, polydimethylsiloxane 2%, glycerin 8%, butylene glycol 5%, propylene glycol 4%, acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer 0.2%, carbomer 0.1%, dipotassium glycyrrhizinate 0.2%, allantoin 0.2%, disodium EDTA 0.05%, aminomethylpropanol 0.1%, methylparaben 0.05%, phenoxyethanol 0.5%, and water the balance to 100%.

The cosmetic composition was prepared in the same manner as in example 2.

Comparative example 1

This comparative example provides a cosmetic composition in which the amount and composition of the raw materials are the same as those of example 2, except that no butylated hydroxytoluene was added to the raw materials of the cosmetic composition, i.e., the mass fraction of butylated hydroxytoluene was 0.

In the preparation method of the cosmetic composition of the present comparative example, the procedure and process parameters were the same as in example 2 except that no butylated hydroxytoluene was added to the A-component.

Comparative example 2

This comparative example provides a cosmetic composition, except that the raw materials of the cosmetic composition are not added with the skin-soothing rutin, i.e., the mass fraction of the skin-soothing rutin is 0, the amounts and compositions of the raw materials are the same as those of example 2.

The procedure and process parameters for the preparation of the cosmetic composition of this comparative example were the same as in example 2, except that no troxerutin was added to the D component.

Comparative example 3

This comparative example provides a cosmetic composition, except that the raw materials of the cosmetic composition were not added with rutin and butylhydroxytoluene, i.e., the mass fractions of rutin and butylhydroxytoluene were 0, the amounts and compositions of the raw materials were the same as those of example 2.

In the preparation method of the cosmetic composition of the comparative example, the procedure and process parameters were the same as in example 2 except that butylated hydroxytoluene was not added to the A component, and that troxerutin was not added to the D component.

Comparative example 4

This comparative example provides a cosmetic composition in which the amount and composition of the raw materials are the same as those of example 2, except that no dipeptide diamino Ding Xianbian-based amide diacetate was added to the raw materials of the cosmetic composition, i.e., the mass fraction of dipeptide diamino Ding Xianbian-based amide diacetate was 0.

The procedure and process parameters for the preparation of the cosmetic composition of this comparative example were the same as in example 2, except that no dipeptide diamino Ding Xianbian-based amide diacetate was added to the D-component.

Comparative example 5

This comparative example provides a cosmetic composition in which the amount and composition of the raw materials are the same as those of example 2, except that no acetyl tetrapeptide-2 is added to the raw materials of the cosmetic composition, i.e., the mass fraction of acetyl tetrapeptide-2 is 0.

The procedure and process parameters for the preparation of the cosmetic composition of this comparative example were the same as in example 2, except that no acetyltetrapeptide-2 was added to the D component.

Comparative example 6

This comparative example provides a cosmetic composition, except that the raw materials of the cosmetic composition were not added with the dipeptide diamino Ding Xianbian-base amid diacetate and the acetyl tetrapeptide-2, i.e., the mass fractions of the dipeptide diamino Ding Xianbian-base amid diacetate and the acetyl tetrapeptide-2 were each 0, and the amounts and compositions of the raw materials were the same as those of example 2.

The procedure and process parameters for the preparation of the cosmetic composition of this comparative example were the same as in example 2, except that no dipeptide diamino Ding Xianbian-based amide diacetate and no acetyl tetrapeptide-2 were added to the D component.

In order to verify the technical effects of the examples and comparative examples, the following experimental examples were specially set.

Experimental example 1 stability test

The cosmetic compositions provided in the above examples and comparative examples were subjected to stability tests, the stability test methods are as follows:

(1) Heat resistance test: the samples were poured into 2 tubes of 20.phi. 20 mm.times.120. 120 mm, respectively, to a liquid level of about 80. 80 mm and a clean stopper was applied. One test tube was placed in a thermostatic incubator previously adjusted to 45℃and taken out after 1 week, 2 weeks, 4 weeks and 8 weeks, respectively, and after returning to room temperature, the color change was compared with the test sample of the other test tube.

(2) And (3) light test: the samples were poured into 2 tubes of 20.phi. 20 mm.times.120. 120 mm, respectively, to a liquid level of about 80. 80 mm and a clean stopper was applied. One test tube was placed in an illumination box, taken out after 1 week, 2 weeks, 4 weeks and 8 weeks, and returned to room temperature, and compared with the sample of the other test tube for color change. The specific results are shown in Table 1.

TABLE 1

As can be seen from the data in Table 1, the addition of An Fu rutin can slow down the color change speed of astaxanthin at a level of more than 0.05, and the use of the butylhydroxytoluene and the skin-calming rutin simultaneously has the effects of resisting oxidation and enhancing the synergy, can prevent the color change of astaxanthin, ensures the color stability of the product and ensures that the product does not change color in the shelf life.

Experimental example 2 antioxidant Activity test

DPPH is a stable free radical whose ethanol solution is purple and has a maximum absorption peak of 517nm in the visible region. When a radical scavenger is added to the DPPH solution, the color of the solution becomes lighter, the absorbance at 517nm decreases, and the degree of decrease in absorbance is linearly related to the degree of radical scavenging. Thus, it can be used to detect radical scavenging and thereby evaluate the antioxidant capacity of a substance, expressed as the Scavenging Rate (SR), the greater the scavenging rate, the greater the antioxidant capacity.

The cosmetic compositions provided in examples 1 to 10 and comparative examples 1 to 6 were tested for antioxidant activity while example 2 without astaxanthin was used as a control group. The experimental method for testing the antioxidant activity is as follows: taking 1g of cosmetic composition, adding 2mL of absolute ethyl alcohol, adding 2mL of 60 mu mol/L DPPH solution after complete dissolution, uniformly mixing, standing for 30min, zeroing by the absolute ethyl alcohol, and measuring the absorbance at 517nm to be Ai; the same method is to take 2mL absolute ethanol solvent and 2mL DPPH solution to be mixed uniformly, and the absorbance is determined to be Ac; then, 1g of the cosmetic composition was dissolved, 2mL of absolute ethyl alcohol was added thereto, and 2mL of absolute ethyl alcohol solvent was added thereto and mixed uniformly, whereby the absorbance was determined as Aj. The radical scavenging rate was calculated according to the following formula:

clearance SR (%) = [1- (Ai-Aj)/Ac ] ×100%

Wherein Aj is the contribution of the reaction sample itself to absorbance; ai is the absorbance value of the sample after DPPH action; ac is the absorption of DPPH itself at the measurement wavelength.

The results of the antioxidant activity test are shown in Table 2.

TABLE 2

The results of the table show that compared with comparative example 1, the astaxanthin emulsion has better capability of scavenging free radicals, has better antioxidant effect and can delay aging.

Experimental example 3 wrinkle-removing Effect test

30 women aged 25-55 years were randomly selected as the trial, and the selected volunteers exhibited fine lines on the face, evident wrinkles, and a flaccid appearance. The using mode is as follows: after skin cleansing, the cosmetic composition of example 10 was applied to the entire face and eyes uniformly, gently massaged to complete absorption, once a day each morning and evening, and used continuously for 2 months.

Measuring instrument: visia-CR

Evaluation criteria: the wrinkle ratio difference is the difference between the wrinkle ratio after the use of the product and the wrinkle ratio before the use of the product, and a negative value indicates that the wrinkles are reduced after the use of the product, and the results are shown in Table 3:

TABLE 3 Table 3

From the data in the table, the cosmetic composition provided by the invention has remarkable effects of improving fine lines, relieving skin relaxation and enhancing skin moisture retention; the astaxanthin, the skin-calming rutin and the butylhydroxytoluene added into the cosmetic composition provide strong oxidation resistance, effectively prevent the discoloration of the product and delay the skin aging. Meanwhile, the added dipeptide diamino Ding Xianbian-base amide diacetate and acetyl tetrapeptide-2 effectively resist and supplement the loss of collagen, and have good anti-aging effect.

In addition, fig. 1 to 4 also compare the effects before and after the use of the cosmetic composition. FIG. 1 is a comparison of wrinkles before and after 8 weeks of subject 1 using the cosmetic composition of example 10; FIG. 2 is a comparison of wrinkles before and after 8 weeks of use of the cosmetic composition of example 10 in subject 2; FIG. 3 is a comparison of subject 2 before and after 8 weeks of use of the cosmetic composition of example 10; FIG. 4 is a visual-CR picture of subject 2 after 8 weeks of use of the cosmetic composition of example 10. As can be seen from fig. 1 to 4, the number of wrinkles in the subject after 8 weeks of application of the cosmetic composition was smaller than before application, and the depth of wrinkles was shallower than before application. Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.

Claims

1. A cosmetic composition with the effects of removing wrinkles and delaying aging is characterized by comprising the following raw materials in parts by mass:

2. A method of preparing a cosmetic composition according to claim 1, comprising the steps of:

3. A cosmetic having the efficacy of removing wrinkles and delaying aging, comprising the cosmetic composition of claim 1.