CN110448494A - A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect - Google Patents

A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect Download PDF

Info

Publication number
CN110448494A
CN110448494A CN201910845114.9A CN201910845114A CN110448494A CN 110448494 A CN110448494 A CN 110448494A CN 201910845114 A CN201910845114 A CN 201910845114A CN 110448494 A CN110448494 A CN 110448494A
Authority
CN
China
Prior art keywords
weight
parts
skin
extract
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910845114.9A
Other languages
Chinese (zh)
Inventor
高杨
石宣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baozi (chengdu) Health Management Co Ltd
Original Assignee
Baozi (chengdu) Health Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baozi (chengdu) Health Management Co Ltd filed Critical Baozi (chengdu) Health Management Co Ltd
Priority to CN201910845114.9A priority Critical patent/CN110448494A/en
Publication of CN110448494A publication Critical patent/CN110448494A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9722Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a kind of with the anti-ageing skin care compositions for repairing effect and its application and preparation method.The ingredient of the composition includes, by weight, including skin conditioning agent 10-15 parts by weight;Moisturizer 6-10 parts by weight;Emollient 6-10 parts by weight;Antioxidant 0.1-0.5 parts by weight Emulsifier 1-5 parts by weight, assistant for emulsifying agent 0.5-1.0 parts by weight, thickener 0.1-1.0 parts by weight, chelating agent 0.01-0.05 parts by weight, preservative 0.1-0.3 parts by weight, solvent supply 100 parts by weight.The present invention medical mechanism different using each ingredient, gives full play to the synergistic function between each ingredient, and gained constituent is enabled to prevent the injury of ultraviolet light bring, remove existing free radical, long-acting lasting sustained release aging ingredient, perfects the basic barrier function of skin, promotes the new life of collagen, thicken skin, inhibit the degradation of collagen, collects anti-ageing, bright color, cutin is repaired in one, various aspects nursing skin.

Description

A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect
Technical field
The present invention relates to daily chemical products technical field more particularly to it is a kind of with it is anti-ageing repair effect skin care compositions and It is applied and preparation method.
Background technique
Skin aging is the skin aging phenomenon as caused by natural cause or non-natural factor.Skin histology day after people's birth It reaches increasingly, function is gradually active, will start to degenerate when reaching certain age, and this degeneration is often unconsciously slow in people Slow-motion row.The growth stage of skin histology generally ends at 25 years old or so, and the growth with aging of skin carry out simultaneously after this, skin Skin elastic fibers is gradually thicker, and after 35 years old, the aging rate of skin is accelerated, increasingly apparent.
At every moment all in aging, elasticity slowly reduces skin, and thins down, more and more fragile and relaxation, Visual impression to people is exactly to be wrinkled.According to the Aging Mechanism of skin, the approach of anti-aging can be inquired into.Sum up master It include: to protect the skin from external environment stimulation;Extra free radical in scavenger-cell;Skin Cell is repaired and is mended Fill nutrition.Skin anti-aging is to prevent skin from the gradually function of property occurs and organic move back sexually revises because of time passage, is showed To prevent wrinkle, drying, playing bits, loose and color spot.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of skin care compositions, can not only remove existing free radical, and And self maintenance ability of skin immunity and Skin Cell can be improved.
The present invention adopts the following technical scheme that realization.
A kind of composition for skin care, the component including following parts by weight:
The skin conditioning agent is selected from package retinol, composite nerve amide, carnosine, tetrahydro methylpyrimidine carboxylic acid, whey One or more of albumen, panthenol, green algal extract, phytoestrogen, Wild soybean peptide;It more preferably include above-mentioned whole groups Point;
Preferably, the skin conditioning agent includes: package retinol 1-5 parts by weight, composite nerve amide 0.1-0.5 weight Part, carnosine 0.1-0.5 parts by weight, tetrahydro methylpyrimidine carboxylic acid 0.1-2.0 parts by weight, lactalbumin 0.1-1.0 parts by weight, panthenol 0.1-2.0 parts by weight, green algal extract 1-5 parts by weight, phytoestrogen 0.1-2 parts by weight, Wild soybean peptide 0.1-1.0 weight Part;
Wherein, the phytoestrogen is selected from isoflavones, elegant jessamine root extract, polygonum cuspidate root extract, Thailand elegant jessamine One of root extract, rattleroot root extract, Angelica roots, pomegranate rind extract, red clover flower extract Or it is several;It more preferably include above-mentioned whole components;The composite nerve amide is selected from Cer EOS, Cer NS, neural acyl One or more of amine 3, ceramide 4, Cer AP II;It more preferably include above-mentioned whole components;
The moisturizer is selected from 1,3- propylene glycol, glycerol, Sodium Hyaluronate, polyglutamic acid sodium, pungent glycol, 1,2 pentanediols One or more of;It more preferably include above-mentioned whole components;
Preferably, the moisturizer includes 1,3-PD 1-5 parts by weight, glycerol 1-5 parts by weight, Sodium Hyaluronate 0.01-0.1 parts by weight, polyglutamic acid sodium 0.01-0.1 parts by weight, pungent glycol 0.1-0.5 parts by weight, 1,2 pentanediol 0.1-0.5 Parts by weight;
The emollient is selected from one or more of two heptanoate of neopentyl glycol, saualane, octyl polymethyl siloxane; It more preferably include above-mentioned whole components;
Preferably, the emollient includes that two heptanoate 1-5 parts by weight of neopentyl glycol, saualane 1-5 parts by weight, octyl are poly- Methylsiloxane 1-5 parts by weight;
The antioxidant is selected from tocopherol, it is preferable that the tocopherol 0.1-0.5 parts by weight.
Tetrahydro methylpyrimidine carboxylic acid is one of intracorporal natural component of Halophiles, Halophiles body from salt lake, salinized soil, Seawater and desert salt-soda soil are the environment that with high salt, the dry temperature difference is big and has intense UV to irradiate, therefore Yi Keduoyin has Superpower water lock function, and have effects that irradiate resistant to high temperatures, dehydration and ultraviolet light.
Green algal extract is the alcohol extract or water extract of green alga.Green alga (CHLOROPHYTA SPP.) is alkalescent, contains Balanced various nutritions are enriched, protein, lipid, polysaccharide, dietary fiber, vitamin A, B, C, D, E, micro member are rich in Element, minerals, folic acid, chlorophyll and preciousness biologically active element.In addition, also containing a kind of most important composition in green alga: green Algae promotes growth factor-2 0 (CGF), it, which has, induces interferon, and exciting human defence, the macrophage in immuning tissue, T are thin The effect of born of the same parents and B cell, and can promote to using dioxin as the removing toxic substances of the harmful substance of representative pollution environment, Excretion.Greatly Beans isoflavones
Two heptanoate of neopentyl glycol can exempt the defect being hardened for a long time using skin after silicone oil, low viscosity cross knot The branch grease of structure, gas permeability is splendid, very dry and comfortable, and spreadability is good, has excellent penetration property, can promote active ingredient It absorbs, graceful silky impression can be left after use to skin.
Polygonum cuspidate root extract is the alcohol extract or water extract of polygoni cuspidati,radix.Polygonum cuspidate, Chinese medicine name.For polygonaceae plant polygonum cuspidate The dry rhizome and root of (Polygonum cuspidatum Sieb.et Zucc.).Spring, the excavation of two season of autumn, fibrous root is removed, is washed Only, fresh-cut short section or sheet are taken advantage of, is dried.It is distributed in the ground such as northwest, East China, Central China, south China and southwest.Polygonum cuspidate is in China and Japan It is used to treat a variety of slight illness in traditional medicine, there is removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, removing blood stasis and acesodyne, relieving cough and reducing sputum effect.With In jaundice with damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, scald, menostasis, abdominal mass, instep beats damage, cough with lung heat.
Pueraria Mirifica extract is the alcohol extract or water extract of Radix Puerariae, and elegant jessamine (Pueraria Lobata) root is safe A kind of tropical vanilla of state, is also commonly called as: newborn fruit.It belongs to pulse family, Pueraria Mirifica its spy unlike other leguminous plants Vegetable actives composition, these active constituents such as " miroestrols " and " the micro- female alcohol of deoxidation " that has are that other leguminous plants are not had.It is wild Pueraria lobata has the isoflavones components of high-content, not only has lethal effect to human breast cancer cell line, but also have very high Antimutagenesis.
Black cohosh extract is the alcohol extract or water extract of rattleroot, rattleroot (Cimicifuga Romose L. it) is also known as black cohosh root, is brown-black powder shape.Black cohosh root is a kind of perennial wild flower for originating in America northeast.Black cohosh root Can produce oestrogen-like hormone sample effect, adjust incretion balance, thus help to alleviate climacteric insomnia, hectic fever, back pain and Lose one's temper equal malaise symptoms.Black Cohosh P.E has antibacterial, decompression, inhibits cardiac muscle, reducing heart rate, sedation;Black liter Nettle extract is effective in cure to arthritis and osteoporosis.
Angelica extract is the alcohol extract or water extract of angelica root, and Radix Angelicae Sinensis (Angelica sinensis) originates in Ya Zhouxi There are cultivation in portion, Europe and North America various countries more.In terms of pharmacology, root can be used as medicine, and be one of most common Chinese medicine.With enriching blood And blood, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine, anticancer, anti-ageing the effect of preventing always, is immune.
Pomegranate rind extract is the alcohol extract or water extract of granatum, granatum (PUNICA GRANATUM), Chinese medicine name. For the drying pericarp of Punicaceae plant pomegranate Punica granatum L..There is cultivation in China north and south, with Jiangsu, Henan and other places It is more.With relieving diarrhea with astringents, the effect of hemostasis, expelling parasite.It is usually used in chronic diarrhea, protracted dysentery, hematochezia, rectal prolapse, metrorrhagia and metrostaxis, leukorrhagia, malnutrition due to parasitic infestation abdomen Bitterly.
Extracts of red clover is the drying stem of red clover and alcohol extract or water extract with floral leaf;Main ingredient is big The isoflavones such as beans flavones, pratensein.With anticancer, antimalarial, eliminating the phlegm, spasmolysis, it can be used for treating pertussis and branch gas The diseases such as pipe inflammation.
Wild soybean has as basic functional protein, can supplement human body protein, improves the work of various immune factors in cell Property and content, promote various antibody to be formed, body immunity made to be in optimum state, defending and fighting against diseases, improve constitution.
Skin care compositions described in any of the above-described technical solution provided by the present invention all has good anti-ageing, reparation The effect of.
It is an unexpected discovery of the invention that adding the function that the whole in above-mentioned raw materials is remarkably improved composition in the composition Effect.
The present invention also provides compositions described in above-mentioned any one technical solution to have skin care that is anti-ageing, repairing in preparation Application in product.Wherein, the skin care item include facial mask, face cream, essence, toner, lotion, gel, condensation etc..
Anti-ageing, the reparation skin care item are using above-mentioned any one technical solution resulting composition as active component.
Specifically, the present invention provides a kind of lotion, which is characterized in that the component including following parts by weight:
Active component:
Wrap up retinol 1-5 parts by weight, composite nerve amide 0.1-0.5 parts by weight, carnosine 0.1-0.5 parts by weight, tetrahydro Methylpyrimidine carboxylic acid 0.1-2.0 parts by weight, lactalbumin 0.1-1.0 parts by weight, panthenol 0.1-2.0 parts by weight, green algal extract 1-5 parts by weight, phytoestrogen 0.1-2 parts by weight, Wild soybean peptide 0.1-1.0 parts by weight;It is 1,3- propylene glycol 1-5 parts by weight, sweet Oily 1-5 parts by weight, Sodium Hyaluronate 0.01-0.1 parts by weight, polyglutamic acid sodium 0.01-0.1 parts by weight, pungent glycol 0.1-0.5 weight Amount part, 1,2 pentanediol 0.1-0.5 parts by weight, two heptanoate 1-5 parts by weight of neopentyl glycol, saualane 1-5 parts by weight, octyl are poly- Methylsiloxane 1-5 parts by weight, tocopherol 0.1-0.5 parts by weight;
Auxiliary material:
Emulsifier 1-5 parts by weight, assistant for emulsifying agent 0.5-1.0 parts by weight, thickener 0.1-1.0 parts by weight, chelating agent 0.01- 0.05 parts by weight, preservative 0.1-0.3 parts by weight, solvent supply 100 parts by weight;
Wherein, emulsifier be selected from one of the smooth olive oleate of sorb, hydrolecithin, -3 cocounut oil acid esters of polyglycereol or It is several;
Assistant for emulsifying agent is selected from cetostearyl alcohol;
Thickener is selected from hydrolysis Scleroglucan or hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers;
Chelating agent is selected from EDETATE SODIUM;
Preservative is selected from chlorobenzene glycosides ether.
The present invention also provides a kind of preparation methods of above-mentioned emulsion, comprising:
Step 1:
By 1,3- propylene glycol, hydrolysis Scleroglucan, Sodium Hyaluronate, polyglutamic acid sodium it is pre-dispersed it is good after be added fill from In the configuration pot of sub- water and EDETATE SODIUM then heating 80 degree be stirred until homogeneous, by glycerol, chlorobenzene glycosides ether, hydroxy-ethyl acrylate/ Sodium acryloyldimethyl taurate copolymers are sequentially added in configuration pot, are stirred evenly;
Step 2:
By the smooth olive oleate of sorb, hydrolecithin, cetostearyl alcohol, two heptanoate of neopentyl glycol, saualane, gather it is sweet Oily -3 cocounut oil acid esters heat ups 80 degree in oily phase pot, face before homogeneous by octyl polymethyl siloxane, tocopherol, wrap up retinol, Composite nerve amide is added to above-mentioned stirring and dissolving and is uniformly then pumped into main cooker homogeneous 5 minutes, starts stirring cooling;
Step 3:
45 degree or so are cooled to, configuration pot is added in carnosine, tetrahydro methylpyrimidine carboxylic acid, lactalbumin simultaneously and is stirred to equal It is even, continue to cool down;
Step 4:
It is cooled to 38 degree panthenol, green algal extract, pungent glycol, 1,2- pentanediol, phytoestrogen, Wild soybean peptide are added Configuration pot is stirred until homogeneous, and feeding detection discharges after qualified.
Technical solution of the present invention has the following beneficial effects:
The present invention medical mechanism different using each ingredient, gives full play to the synergistic function between each ingredient, so that institute The injury of ultraviolet light bring can be prevented by obtaining constituent, remove existing free radical, and long-acting lasting sustained release aging ingredient is good for The basic barrier function of full skin, promotes the new life of collagen, thickens skin, inhibits the degradation of collagen, collects anti-ageing, mentions Skin lightening color repairs cutin in one, various aspects nursing skin.
Specific embodiment
The embodiments given below are intended to further illustrate the invention.
Embodiment 1-3 and comparative example 1-3 provide a kind of composition respectively, by weight, formula such as the following table 1:
The preparation method of embodiment 1-3 and comparative example 1-3 composition is following steps:
Step 1:
By 1,3- propylene glycol, hydrolysis Scleroglucan, Sodium Hyaluronate, polyglutamic acid sodium it is pre-dispersed it is good after be added fill from In the configuration pot of sub- water and EDETATE SODIUM then heating 80 degree be stirred until homogeneous, by glycerol, chlorobenzene glycosides ether, hydroxy-ethyl acrylate/ Sodium acryloyldimethyl taurate copolymers are sequentially added in configuration pot, are stirred evenly;
Step 2:
By the smooth olive oleate of sorb, hydrolecithin, cetostearyl alcohol, two heptanoate of neopentyl glycol, saualane, gather it is sweet Oily -3 cocounut oil acid esters heat ups 80 degree in oily phase pot, face before homogeneous by octyl polymethyl siloxane, tocopherol, wrap up retinol, Composite nerve amide is added to above-mentioned stirring and dissolving and is uniformly then pumped into main cooker homogeneous 5 minutes, starts stirring cooling;
Step 3:
45 degree or so are cooled to, configuration pot is added in carnosine, tetrahydro methylpyrimidine carboxylic acid, lactalbumin simultaneously and is stirred to equal It is even, continue to cool down;
Step 4:
It is cooled to 38 degree panthenol, green algal extract, pungent glycol, 1,2- pentanediol, phytoestrogen, Wild soybean peptide are added Configuration pot is stirred until homogeneous, and feeding detection discharges after qualified.
Efficacy test one:
Anti-wrinkle effect evaluation
Nature static wrinkle volunteer 180 is chosen to sterilize medicinal alcohol at skin at wrinkle after face cleaning, it will be above-mentioned 180 volunteers are randomly divided into 6 groups, and every group of 30 people, each group smears embodiment 1-3 and comparative example 1-3 respectively, are massaged into complete suction It receives, daily morning and evening respectively using scoring after 1 time, 60 days by 2 standards of grading of table, appraisal result is as shown in table 2.
As shown in Table 2, the lotion anti-wrinkle effect of embodiment 1-3 is good, and volunteer on probation indicates that the anti-wrinkle cream easily absorbs, and protects Wet effect is obvious, and anti-wrinkle effect is good, and after the anti-wrinkle cream 60 days, face's microgroove obviously calms down, and wrinkle effectively reduces or mitigates. The wherein degree of recognition highest of 2 anti-wrinkle cream of embodiment is highly preferred embodiment of the present invention.Non- someone goes out in the questionnaire of subject simultaneously The undesirable conditions such as existing skin allergy, red and swollen phenomenon.
Efficacy test two: the evaluation of red capillary therapeutic effect
180 women for having a red capillary are chosen, after the age cleans face between 25-50 years old, are divided into 6 groups, every group of 30 people, The lotion of suitable 1-3 of the embodiment of the present invention and comparative example 1-3 is taken to be applied on red capillary position respectively, flicking absorbs, It is each daily morning and evening to use primary, continuous use 60 days.It see the table below 3
Effectively (number) Efficient (%) Side effect (number) Side effect rate (%)
Embodiment 1 27 90 0 0
Embodiment 2 29 96 0 0
Embodiment 3 28 93 1 3%
Comparative example 1 6 20 1 3%
Comparative example 2 9 30 0 0
Comparative example 3 8 26 0 0
The judgment criteria of " effective " in table 3 are as follows: red blood trace on face obviously desalinates or disappears.
The judgment criteria of " side effect " in table 3 are as follows: lead to facial pores blocking inflammation or precipitating pigment or skin using product Phenomena such as skin side is coarse occurs.
From table 3 it is observed that the lotion of continuous use inventive embodiments 1-3 composition is efficient using product after 60 days Reach 90% or more, wherein the effective percentage of the lotion of embodiment 2 reaches 96%, therefore the product pair that the present invention is prepared Red blood streak dispelling has good repair, and product is mildly non-stimulated to skin.And the effective percentage of comparative example 1-3 composition is only For 20-30%.
It can be illustrated by above-mentioned efficacy test, the present invention medical mechanism different using each ingredient gives full play to each ingredient Between synergistic function, enable the pre- UV resistance bring injury of gained constituent, remove existing free radical, it is long-acting to hold Long sustained release aging ingredient collects anti-ageing, bright color, repairs cutin in one, various aspects nursing skin.
Specific embodiments of the present invention are described in detail above, but it is merely an example, the present invention is simultaneously unlimited It is formed on particular embodiments described above.To those skilled in the art, any couple of present invention carries out equivalent modifications and Substitution is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and Modification, all should be contained within the scope of the invention.

Claims (10)

1. a kind of composition, which is characterized in that by weight, comprising:
2. composition according to claim 1, which is characterized in that
The skin conditioning agent be selected from package retinol, composite nerve amide, carnosine, tetrahydro methylpyrimidine carboxylic acid, lactalbumin, One or more of panthenol, green algal extract, phytoestrogen, Wild soybean peptide;
The moisturizer is in 1,3- propylene glycol, glycerol, Sodium Hyaluronate, polyglutamic acid sodium, pungent glycol, 1,2 pentanediols It is one or more of;
The emollient is selected from one or more of two heptanoate of neopentyl glycol, saualane, octyl polymethyl siloxane;
The antioxidant is selected from tocopherol.
3. composition according to claim 2, which is characterized in that
The skin conditioning agent include package retinol, composite nerve amide, carnosine, tetrahydro methylpyrimidine carboxylic acid, lactalbumin, Panthenol, green algal extract, phytoestrogen, Wild soybean peptide;
The moisturizer includes 1,3- propylene glycol, glycerol, Sodium Hyaluronate, polyglutamic acid sodium, pungent glycol, 1,2 pentanediols;
The emollient includes two heptanoate of neopentyl glycol, saualane, octyl polymethyl siloxane;
The antioxidant includes tocopherol.
4. composition according to claim 3, which is characterized in that
The skin conditioning agent includes: package retinol 1-5 parts by weight, composite nerve amide 0.1-0.5 parts by weight, carnosine 0.1- 0.5 parts by weight, tetrahydro methylpyrimidine carboxylic acid 0.1-2.0 parts by weight, lactalbumin 0.1-1.0 parts by weight, panthenol 0.1-2.0 weight Part, green algal extract 1-5 parts by weight, phytoestrogen 0.1-2 parts by weight, Wild soybean peptide 0.1-1.0 parts by weight;
The moisturizer include 1,3- propylene glycol 1-5 parts by weight, glycerol 1-5 parts by weight, Sodium Hyaluronate 0.01-0.1 parts by weight, Polyglutamic acid sodium 0.01-0.1 parts by weight, pungent glycol 0.1-0.5 parts by weight, 1,2 pentanediol 0.1-0.5 parts by weight;
The emollient includes two heptanoate 1-5 parts by weight of neopentyl glycol, saualane 1-5 parts by weight, octyl polymethyl siloxane 1-5 parts by weight;
The antioxidant includes tocopherol 0.1-0.5 parts by weight.
5. according to the described in any item compositions of claim 2-4, which is characterized in that
The phytoestrogen be selected from isoflavones, elegant jessamine root extract, polygonum cuspidate root extract, Pueraria Mirifica extract, One or more of rattleroot root extract, Angelica roots, pomegranate rind extract, red clover flower extract;It is excellent Choosing includes above-mentioned whole components;
The composite nerve amide is in Cer EOS, Cer NS, Cer NP, ceramide 4, Cer AP II One or more;It more preferably include above-mentioned whole components.
6. the described in any item compositions of claim 1-5 have the application in skin care item that are anti-ageing and repairing in preparation.
7. application according to claim 6, which is characterized in that the skin care item include facial mask, face cream, essence, feel well Skin water, lotion, gel, condensation.
8. a kind of lotion, which is characterized in that including composition as described in any one in claim 1-5 as active component.
9. lotion according to claim 8, which is characterized in that the lotion further include:
Emulsifier 1-5 parts by weight, assistant for emulsifying agent 0.5-1.0 parts by weight, thickener 0.1-1.0 parts by weight, chelating agent 0.01-0.05 Parts by weight, no added preservative 0.1-0.3 parts by weight, solvent supply 100 parts by weight;
Wherein, emulsifier is selected from one of the smooth olive oleate of sorb, hydrolecithin, -3 cocounut oil acid esters of polyglycereol or several Kind;
Assistant for emulsifying agent is selected from cetostearyl alcohol;
Thickener is selected from hydrolysis Scleroglucan or hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers;
Chelating agent is selected from EDETATE SODIUM;
No added preservative is selected from chlorobenzene glycosides ether.
10. a kind of method for preparing the described in any item lotions of claim 7-9, which comprises the steps of:
Step 1:
By 1,3- propylene glycol, hydrolysis Scleroglucan, Sodium Hyaluronate, polyglutamic acid sodium it is pre-dispersed it is good after be added and fill deionized water It is stirred until homogeneous with then heating up 80 ° in the configuration pot of EDETATE SODIUM, by glycerol, chlorobenzene glycosides ether, hydroxy-ethyl acrylate/acryloyl Dimethyltaurine sodium copolymer is sequentially added in configuration pot, is stirred evenly;
Step 2:
By the smooth olive oleate of sorb, hydrolecithin, cetostearyl alcohol, two heptanoate of neopentyl glycol, saualane, polyglycereol -3 Cocounut oil acid esters heat up 80 ° in oily phase pot, face octyl polymethyl siloxane, tocopherol, package retinol, compound mind before homogeneous Above-mentioned stirring and dissolving is added to through amide to be uniformly then pumped into main cooker homogeneous 5 minutes, starts stirring cooling;
Step 3:
45 ° or so are cooled to, configuration pot is added in carnosine, tetrahydro methylpyrimidine carboxylic acid, lactalbumin simultaneously and is stirred until homogeneous, after Continuous cooling;
Step 4:
It is cooled to 38 ° and configuration is added in panthenol, green algal extract, pungent glycol, 1,2- pentanediol, phytoestrogen, Wild soybean peptide Pot is stirred until homogeneous, and feeding detection discharges after qualified.
CN201910845114.9A 2019-09-08 2019-09-08 A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect Pending CN110448494A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910845114.9A CN110448494A (en) 2019-09-08 2019-09-08 A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910845114.9A CN110448494A (en) 2019-09-08 2019-09-08 A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect

Publications (1)

Publication Number Publication Date
CN110448494A true CN110448494A (en) 2019-11-15

Family

ID=68491151

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910845114.9A Pending CN110448494A (en) 2019-09-08 2019-09-08 A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect

Country Status (1)

Country Link
CN (1) CN110448494A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111067835A (en) * 2020-01-10 2020-04-28 西安润玉医疗科技有限公司 Whitening composition for resisting skin saccharification reaction and preparation method thereof
CN111184657A (en) * 2020-02-24 2020-05-22 广东密尚生物科技有限公司 Moisturizing isolation emulsion and preparation method thereof
CN111494246A (en) * 2020-04-26 2020-08-07 李云 Oxygen injection component for cosmetics
CN111743823A (en) * 2020-07-16 2020-10-09 广州蜜妆生物科技有限公司 Skin detoxifying essence milk
CN111789777A (en) * 2020-08-15 2020-10-20 广州市珍榜日用化工有限公司 Skin care cream with immediate tightening and anti-aging effects and preparation method thereof
CN111973519A (en) * 2020-09-11 2020-11-24 广州子芽生物科技有限公司 Composition with repairing and anti-aging effects and application of composition in cosmetics
CN111973472A (en) * 2019-12-05 2020-11-24 上海遇鑫生物科技有限公司 Ceramide activated water and preparation method thereof
CN112245315A (en) * 2020-10-14 2021-01-22 广州环亚化妆品科技有限公司 Ceramide facial mask with moisturizing and repairing effects and preparation method thereof
CN113712842A (en) * 2020-05-25 2021-11-30 基元美业生物科技(上海)有限公司 Composition and application thereof in preparation of cosmetics and medical instruments
CN113943343A (en) * 2021-10-15 2022-01-18 广州奥利生物科技有限公司 Blue copper peptide with anti-aging and repairing effects and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109549917A (en) * 2019-02-14 2019-04-02 成都市葆姿健康管理有限公司 It is a kind of to have effects that skin care compositions that antiallergic is releived and its application and preparation method
CN109662928A (en) * 2019-02-14 2019-04-23 成都市葆姿健康管理有限公司 A kind of skin care compositions and its application and preparation method with sun-proof reparation effect
CN109662904A (en) * 2019-02-14 2019-04-23 成都市葆姿健康管理有限公司 It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method
CN109700753A (en) * 2019-02-14 2019-05-03 成都市葆姿健康管理有限公司 A kind of skin care compositions and its application and preparation method with moisturizing anti-oxidation efficacy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109549917A (en) * 2019-02-14 2019-04-02 成都市葆姿健康管理有限公司 It is a kind of to have effects that skin care compositions that antiallergic is releived and its application and preparation method
CN109662928A (en) * 2019-02-14 2019-04-23 成都市葆姿健康管理有限公司 A kind of skin care compositions and its application and preparation method with sun-proof reparation effect
CN109662904A (en) * 2019-02-14 2019-04-23 成都市葆姿健康管理有限公司 It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method
CN109700753A (en) * 2019-02-14 2019-05-03 成都市葆姿健康管理有限公司 A kind of skin care compositions and its application and preparation method with moisturizing anti-oxidation efficacy

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111973472A (en) * 2019-12-05 2020-11-24 上海遇鑫生物科技有限公司 Ceramide activated water and preparation method thereof
CN111067835A (en) * 2020-01-10 2020-04-28 西安润玉医疗科技有限公司 Whitening composition for resisting skin saccharification reaction and preparation method thereof
CN111184657A (en) * 2020-02-24 2020-05-22 广东密尚生物科技有限公司 Moisturizing isolation emulsion and preparation method thereof
CN111494246A (en) * 2020-04-26 2020-08-07 李云 Oxygen injection component for cosmetics
CN113712842A (en) * 2020-05-25 2021-11-30 基元美业生物科技(上海)有限公司 Composition and application thereof in preparation of cosmetics and medical instruments
CN113712842B (en) * 2020-05-25 2023-06-13 基元美业生物科技(上海)有限公司 Composition and application thereof in preparation of cosmetics and medical devices
CN111743823A (en) * 2020-07-16 2020-10-09 广州蜜妆生物科技有限公司 Skin detoxifying essence milk
CN111789777A (en) * 2020-08-15 2020-10-20 广州市珍榜日用化工有限公司 Skin care cream with immediate tightening and anti-aging effects and preparation method thereof
CN111973519A (en) * 2020-09-11 2020-11-24 广州子芽生物科技有限公司 Composition with repairing and anti-aging effects and application of composition in cosmetics
CN112245315A (en) * 2020-10-14 2021-01-22 广州环亚化妆品科技有限公司 Ceramide facial mask with moisturizing and repairing effects and preparation method thereof
CN113943343A (en) * 2021-10-15 2022-01-18 广州奥利生物科技有限公司 Blue copper peptide with anti-aging and repairing effects and preparation method and application thereof

Similar Documents

Publication Publication Date Title
CN110448494A (en) A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect
CN109700753A (en) A kind of skin care compositions and its application and preparation method with moisturizing anti-oxidation efficacy
CN108670943A (en) A kind of moisturizing, whitening, light spot composition of plant extracts
KR20120038585A (en) Oriental medicine extract for prevention of alopecia and hair article composition
CN109662928A (en) A kind of skin care compositions and its application and preparation method with sun-proof reparation effect
KR101986186B1 (en) Cpmposition for care of dermatic disease comprinsing plant extract
CN109662904A (en) It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method
KR101829892B1 (en) A cosmetic composition comprising fraxinus rhynchophylla extract and calystegia soldanella extract
JP2003192605A (en) Lipase inhibitant
CN106265370A (en) A kind of shampoo effectively preventing pathologic alopecia and preparation method thereof
CN112190593B (en) Polysaccharide composition for inhibiting TRPV1 pathway and preparation method and application thereof
CN108888563A (en) A kind of water profit thirst quenching hydra-balance mask and preparation method thereof
Das et al. Cactus: Chemical, nutraceutical composition and potential bio‐pharmacological properties
Fahamiya et al. Unani perspective of Khatmi (Althaea officinalis)
Shi et al. The genus Orobanche as food and medicine: An ethnopharmacological review
KR100712249B1 (en) Oily to acne skin cosmetics composite containing oriental herb extract and manufacturing method thereof
CN108653137B (en) Composition and application thereof in preparation of beauty cosmetics
KR101980887B1 (en) A cosmetic composition comprising trichosanthes kirilowii extract and metaplexis japonica extract
CN109908069A (en) A kind of milky lotion of multifunctional plant extractive and preparation method thereof
CN109125165A (en) A kind of compact face of repairing is releived facial mask and preparation method thereof
CN112891271A (en) Composition for sensitive muscle barrier repair and application of composition in skin care product
KR101795917B1 (en) Antimicrobial compositions for perfume containing natural material extract
KR20190027178A (en) A cosmetic composition comprising centipeda minima extract
Saini et al. A review on phytoconstituents: the potent synergistic approach in antimicrobial formulations
CN115337239B (en) Essential oil with relieving and repairing effects and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20191115