CN112932990A - Anti-aging composition and preparation method and application thereof - Google Patents
Anti-aging composition and preparation method and application thereof Download PDFInfo
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- CN112932990A CN112932990A CN202110407765.7A CN202110407765A CN112932990A CN 112932990 A CN112932990 A CN 112932990A CN 202110407765 A CN202110407765 A CN 202110407765A CN 112932990 A CN112932990 A CN 112932990A
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- retinol
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- aging composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-aging composition and a preparation method and application thereof. Wherein the anti-aging composition is prepared from the following components: behenyl alcohol, emulsifier, dimethyl silicone oil, type III collagen, retinol oil solution, preservative and deionized water. The anti-aging composition utilizes the unique structure and biological activity of the type III collagen to protect the retinol which has larger irritation to the skin in the composition, so that the retinol is slowly released to reduce the irritation to the skin, thereby ensuring the anti-aging activity of the retinol and enabling the retinol to play a role in the tolerance range of the skin.
Description
Technical Field
The invention relates to an anti-aging composition, in particular to an anti-aging composition containing type III collagen and retinol, and further relates to a preparation method and application of the anti-aging composition, belonging to the technical field of cosmetics.
Background
With the increase of human age, the synthesis capacity of fibroblasts is reduced, collagen fibers are solidified, intercellular mucopolysaccharide is reduced, skin loses softness, elasticity and luster, and is aged, meanwhile, fiber breakage, lipoatrophy, sweat gland and sebaceous gland secretion of dermis are reduced, and a series of aging phenomena such as color spots, wrinkles and the like appear on the skin. Retinol is a precursor substance of tretinoin, has great potential as a topical anti-aging molecule, is first marketed in the us in the 70-80 s as a drug for treating acne, and its anti-aging effect was discovered later. After years of research, the drug is finally the first external drug for resisting photoaging, which is approved by FDA (American food and drug administration). However, retinol has obvious irritation to skin, and is sensitive, red and stabbing, even itchy and red swelling easily caused by improper use. Therefore, on the premise of ensuring the anti-aging effect of retinol, how to reduce the irritation of the product to the skin is a problem which is continuously researched in the field of cosmetics.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an anti-aging composition containing retinol and type III collagen, and the type III collagen in the composition is beneficial to improving the irritation of the retinol to the skin and improving the experience feeling of products while ensuring the anti-aging effect of the composition. In addition, the invention also provides a preparation method of the anti-aging composition.
In order to achieve the purpose, the invention adopts the following technical scheme:
an anti-aging composition, which is prepared from the following components: behenyl alcohol, emulsifier, dimethyl silicone oil, type III collagen, retinol oil solution, preservative and deionized water.
It is preferable that: the anti-aging composition is prepared from the following components in percentage by weight: behenyl alcohol: 0.1-1%, emulsifier: 1-3%, dimethicone: 1-3%, type III collagen: 5-10%, retinol oil solution: 0.05-0.5%, preservative: 0.5-1% and deionized water: 50 to 90 percent.
It is preferable that: the emulsifier is DELTA MB.
It is preferable that: the viscosity of the simethicone is 5 cst.
It is preferable that: the preservative is phenoxyethanol.
Another object of the present invention is a method for preparing the antiaging composition, which comprises the following steps:
1) mixing the behenyl alcohol, the dimethicone and the emulsifier according to the weight percentage, stirring and mixing at 80-85 ℃ until all the components are completely dissolved to obtain a mixture A;
2) heating deionized water to 80-85 ℃, adding the mixture A obtained in the step 1) into the heated deionized water, homogenizing for 3-5 minutes, and then cooling to below 50 ℃;
3) adding the III type collagen and the retinol oil solution into the mixture cooled in the step 2), stirring all the components to be uniformly mixed,
4) adding a preservative into the mixture obtained in the step 3), stirring until the preservative is uniformly mixed, and cooling the mixture to room temperature to obtain the anti-aging composition.
The invention further aims to provide the application of the anti-aging composition in anti-aging skin care products.
The anti-aging composition utilizes the unique structure and biological activity of the type III collagen to protect the retinol with larger skin irritation in the composition, so that the retinol is slowly released to reduce the irritation to the skin, and even under the condition of larger addition amount of the retinol, the anti-aging composition can reduce the irritation to the skin on the premise of ensuring the anti-aging effect, so that the anti-aging composition can act within the tolerance range of the skin, and effectively solves the problem of overlarge irritation generally existing in the application of the retinol in the industry.
Detailed Description
The following specific examples further illustrate specific embodiments of the invention. Unless otherwise specified, each raw material used in the present invention may be commercially available.
According to one aspect of the invention, an anti-aging composition is provided, which is prepared from the following components in percentage by weight: behenyl alcohol: 0.1-1%, emulsifier: 1-3%, dimethicone: 1-3%, type III collagen 5-10%, retinol oil solution: 0.05-0.5%, preservative: 0.5-1%, and deionized water: the balance being.
In the anti-aging composition, the behenyl alcohol can be used as a co-emulsifier to play a role in stabilizing the anti-aging composition; the emulsifier can be prepared from French Jiafa lion company
DELTA MB, the main component of which is the mixture of polyglycerol-6 distearate, jojoba esters, polyglycerol-3 beeswax ester and cetyl alcohol, has good emulsifying property and wider pH compatibility (3-13), and can be suitable for the emulsification of various components difficult to emulsify; the dimethyl silicone oil is used as skin moistening oil, has good compatibility with each component in the anti-aging composition, can form a thin layer on the surface of the skin and can be kept for a long time, and the viscosity of the dimethyl silicone oil is preferably 5 cst; the retinol oil solution can be used as GS50 from DSM, Netherlands, which is an easily handled solution stabilized by the antioxidants BHA and BHT of retinol in polysorbate as the active ingredient, and has the effects of reducing the effects of photodamage to the skin, improving the appearance of fine lines and wrinkles, improving skin firmness and elasticity, reducing skin roughness, reducing discolored and mottled pigmentation, and rebalancing the skin color; in addition, the preservative can adopt phenoxyethanol, specifically can adopt Optiphen GP of American Ashland company, and the main effective part of the preservative is phenoxyethanol.
Collagen is a protein widely distributed in human connective tissue, and is the most abundant protein in human body, accounting for 25-35% of the total protein. Its main functions are to maintain the extracellular environment, maintain the normal physiological functions of tissue and organ, repair the injury of body, etc. Collagen is a natural biological resource, has biological histocompatibility expected by other high molecular materials, and has supporting elasticity and degradability for cells, so that the collagen can be widely applied to industries such as medicines, cosmetics and the like. The III type collagen adopted by the invention realizes large-scale production of active collagen by utilizing a biological fermentation technology, and has good biological activity. The crystal structure characterization of the type III collagen proves that the sequence of the collagen is 100 percent identical to the corresponding sequence of human collagen, and the collagen has a triple-helix structure, a flexible angle, very strong cell adhesion activity and a water locking function. The structure is 164.88. High flexibility, rich cell binding sites and high cell adhesion activity. The unique biological activity of the compound can adhere to the retinol, and the retinol is protected by utilizing collagen, so that the retinol is slowly released and gradually converted into retinoic acid, thereby playing the role of resisting aging.
According to another aspect of the present invention, there is also provided a method for preparing the anti-aging composition, the method comprising the steps of:
1) mixing the behenyl alcohol, the dimethicone and the emulsifier according to the weight percentage, stirring and mixing at 80-85 ℃ until all the components are completely dissolved to obtain a mixture A;
2) heating deionized water to 80-85 ℃, adding the mixture A obtained in the step 1) into the heated deionized water, homogenizing for 3-5 minutes, and then cooling to below 50 ℃;
3) adding the III type collagen and the retinol oil solution into the mixture cooled in the step 2), stirring for 3-5 minutes until all the components are uniformly mixed,
4) adding a preservative into the mixture obtained in the step 3), stirring for 1-3 minutes until the mixture is uniformly mixed, cooling the mixture to room temperature, and filling to obtain the anti-aging composition.
The anti-aging composition can be used as an anti-aging component to be applied to skin care products/cosmetics, such as face cream, so as to play a role in resisting aging.
Example 1
An anti-aging composition is prepared from the following components in percentage by weight: behenyl alcohol: 0.5%, DELTA MB: 1.5%, dimethicone (5 cst): 2%, type III collagen: 6%, retinol oil solution GS 50: 0.05%, preservative Optiphen GP: 0.5%, deionized water: the rest is; the preparation method of the anti-aging composition comprises the following steps:
1) mixing behenyl alcohol, simethicone and DELTA MB, stirring and mixing at 85 ℃ until all components are completely dissolved to obtain a mixture A;
2) heating deionized water to 85 ℃, adding the mixture A obtained in the step 1) into the heated deionized water, homogenizing for 3 minutes, and then cooling to 35 ℃;
3) adding the type III collagen and the retinol oil solution GS50 into the mixture cooled in the step 2), stirring for 3 minutes at the temperature until the components are uniformly mixed,
4) adding a preservative into the mixture obtained in the step 3), stirring for 2 minutes until the mixture is uniformly mixed, cooling the mixture to room temperature, and filling to obtain the anti-aging composition.
Example 2
An anti-aging composition is prepared from the following components in percentage by weight: behenyl alcohol: 0.3%, DELTA MB: 3% dimethicone (5 cst): 3%, type III collagen: 5%, retinol oil solution GS 50: 0.3%, preservative Optiphen GP: 0.7%, deionized water: the rest is; the preparation process of the anti-aging composition is similar to that of example 1.
Example 3
An anti-aging composition is prepared from the following components in percentage by weight: behenyl alcohol: 1.0%, DELTA MB: 2.6%, dimethicone (5 cst): 1%, type III collagen: 10%, retinol oil solution GS 50: 0.5%, preservative Optiphen GP: 0.5%, deionized water: the rest is; the preparation process of the anti-aging composition is similar to that of example 1.
Example 4
An anti-aging composition is prepared from the following components in percentage by weight: behenyl alcohol: 0.1%, DELTA MB: 2%, dimethicone (5 cst): 2.7%, type III collagen: 7.5%, retinol oil solution GS 50: 0.28%, preservative Optiphen GP: 1.0%, deionized water: the rest is; the preparation process of the anti-aging composition is similar to that of example 1.
Comparative example 1
The difference from example 1 is that no type III collagen fraction is contained, and the remaining components and the component contents are the same as those in example 1.
Comparative example 2
The difference from example 2 is that no type III collagen fraction is contained, and the remaining components and the component contents are the same as those in example 2.
Comparative example 3
The difference from example 3 is that no type III collagen fraction is contained, and the remaining components and the component contents are the same as those in example 3.
Comparative example 4
The difference from example 4 is that no type III collagen fraction is contained, and the remaining components and the component contents are the same as those in example 4.
The anti-aging compositions prepared in examples 1 to 4 and comparative examples 1 to 4 were respectively subjected to a human body patch test according to the following test protocols:
the number of tested persons: 30 persons, age: 25-45 years old
The test method comprises the following steps: selecting a qualified spot tester, placing 0.0220mg (ointment) of a tested object in the spot tester by a closed spot test method, externally applying a medical adhesive tape on the back of the tested object, removing the tested object after 24 hours, observing skin reactions respectively at 0.5 hour, 24 hours and 48 hours after the spot test, and recording the results according to the skin reaction grading standard in the cosmetic hygiene Specification (2015 edition). Table 1 shows the test results:
TABLE 1 test results
As can be seen from the patch test results in Table 1, in the test process of the anti-aging composition added with type III collagen, 2 cases of subjects have suspicious or above reactions, so that the test object can be judged not to cause adverse reactions on the skin of secondary subjects; in the test process, the anti-aging composition without the type III collagen has suspicious reactions of different degrees, so that the test object can be judged to cause adverse reactions to the skin of the testee. That is, in the anti-aging composition of the present invention, the type III collagen can effectively reduce the irritation of retinol to the skin, and the effect is more significant.
The present invention has been described in detail with reference to the preferred embodiments. However, variations and additions to the embodiments will become apparent to those of ordinary skill in the art upon a reading of the foregoing description. It is the intention of the applicants that all such variations and additions fall within the scope of the claims. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Any modification and improvement of this product, and the substitution and use of the same or similar substances within the scope or range of patents, shall fall within the scope of protection of this invention.
Claims (7)
1. An anti-aging composition characterized by: the composition is prepared from the following components: behenyl alcohol, emulsifier, dimethyl silicone oil, type III collagen, retinol oil solution, preservative and deionized water.
2. The anti-aging composition according to claim 1, characterized in that: the anti-aging composition is prepared from the following components in percentage by weight: behenyl alcohol: 0.1-1%, emulsifier: 1-3%, dimethicone: 1-3%, type III collagen 5-10%, retinol oil solution: 0.05-0.5%, preservative: 0.5-1%, and deionized water: the balance being.
3. Anti-ageing composition according to claim 1 or 2, characterized in that: the emulsifier is DELTA MB.
4. Anti-ageing composition according to claim 1 or 2, characterized in that: the viscosity of the simethicone is 5 cst.
5. Anti-ageing composition according to claim 1 or 2, characterized in that: the preservative is phenoxyethanol.
6. A process for the preparation of an anti-ageing composition according to any one of claims 1 to 5, wherein: the preparation method comprises the following steps:
1) mixing the behenyl alcohol, the dimethicone and the emulsifier according to the weight percentage, stirring and mixing at 80-85 ℃ until all the components are completely dissolved to obtain a mixture A;
2) heating deionized water to 80-85 ℃, adding the mixture A obtained in the step 1) into the heated deionized water, homogenizing for 3-5 minutes, and then cooling to below 50 ℃;
3) adding the III type collagen and the retinol oil solution into the mixture cooled in the step 2), stirring until all components are uniformly mixed,
4) adding a preservative into the mixture obtained in the step 3), stirring until the preservative is uniformly mixed, and cooling the mixture to room temperature to obtain the anti-aging composition.
7. Use of the anti-aging composition according to any one of claims 1 to 5 in anti-aging skin care products.
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| CN202110407765.7A CN112932990A (en) | 2021-04-15 | 2021-04-15 | Anti-aging composition and preparation method and application thereof |
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| CN202110407765.7A CN112932990A (en) | 2021-04-15 | 2021-04-15 | Anti-aging composition and preparation method and application thereof |
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Cited By (3)
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| CN113940897A (en) * | 2021-12-03 | 2022-01-18 | 北京美丽臻颜化妆品有限公司 | Preparation method of anti-aging composition, anti-aging composition and use method thereof |
| CN113952253A (en) * | 2021-09-27 | 2022-01-21 | 水羊化妆品制造有限公司 | Composition for improving stability of cosmetics, cosmetics containing composition and preparation method of cosmetics |
| CN117017869A (en) * | 2023-09-15 | 2023-11-10 | 名宇(广东)化妆品科技有限公司 | Whitening and freckle-removing cream and preparation method thereof |
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| CN117017869A (en) * | 2023-09-15 | 2023-11-10 | 名宇(广东)化妆品科技有限公司 | Whitening and freckle-removing cream and preparation method thereof |
| CN117017869B (en) * | 2023-09-15 | 2024-01-30 | 名宇(广东)化妆品科技有限公司 | Whitening and freckle-removing cream and preparation method thereof |
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