CN108066228A - A kind of moisturizing antibacterial bath cream and preparation method thereof - Google Patents
A kind of moisturizing antibacterial bath cream and preparation method thereof Download PDFInfo
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- CN108066228A CN108066228A CN201810133654.XA CN201810133654A CN108066228A CN 108066228 A CN108066228 A CN 108066228A CN 201810133654 A CN201810133654 A CN 201810133654A CN 108066228 A CN108066228 A CN 108066228A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention provides a kind of moisturizing antibacterial bath creams and preparation method thereof, and shower cream of the invention introduces antibacterial components and moisturizing component, so as to assign the good anti-microbial property of shower cream and performance of keeping humidity, without additionally adding preservative again.Antibacterial components include Rhizoma Fagopyri Dibotryis extract, Eutrema yunnanenses extract and oligofructose, and Rhizoma Fagopyri Dibotryis extract avoids natural extract is in direct contact with the skin from causing to stimulate uncomfortable, slowly release plays antibacterial action He Eutrema yunnanense extract is embedded with hydroxypropyl beta cyclodextrin.Moisturizing component includes L pyrrolidone sodium carboxylates, buckeye bletilla striata composite extract, cactus juice and phytosterol, buckeye bletilla striata composite extract is coated with collagen film, avoid buckeye bletilla striata composite extract is in direct contact with the skin from causing to stimulate discomfort, collagen has good compatibility with human skin, slowly release buckeye bletilla striata composite extract, plays better moisture-keeping function.
Description
Technical field
The present invention relates to daily use chemicals articles for washing technical field, more particularly to a kind of moisturizing antibacterial bath cream and its preparation side
Method.
Background technology
Shower cream is a kind of common daily use chemicals articles for washing, for being used during bathing, belongs to liquid ceanser.In recent years, with
The raising of living standards of the people, shower cream, which gradually substitutes perfumed soap, becomes the first choice of people's bath article.Meanwhile people are to taking a shower
The requirement of dew is also not limited to cleaning skin, but proposes higher requirement, such as performance of keeping humidity and anti-microbial property etc..
Sweat and skin surface scurf of human body discharge etc. combine to form dirt with the dust in air, and accumulate in skin
A large amount of microorganisms are persistently assembled in surface in fouled surfaces, wherein also including a large amount of pathogenic microorganisms, come to human body health care belt tight
It threatens again, particularly cuticula is thicker, fat secretion is vigorous or has the crowd of pruitus and ringworm of the body, the micro- life of pathogenic microorganism
Object growth can aggravate its symptom, seriously affect health.
In addition, traditional shower cream adds a large amount of stronger surface-actives of alkalescence to improve cleaning force and ability of deoiling
The ingredients such as agent, foaming agent and soap base, and the skin of human body is weakly acidic, use for a long time can stimulate skin, destroy sebum
Film so that skin is highly susceptible to external injury.
The content of the invention
Present invention aim to provide a kind of moisturizing antibacterial bath cream and preparation method thereof, have；Good moisturizing
Performance and anti-microbial property.
To achieve the above object, the present invention is achieved by the following scheme：
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5~0.8%, buckeye-bletilla striata composite extract 0.2~0.3%, cactus juice
1.5~2%, phytosterol 0.2~0.3%, 0.5~0.8% , Eutrema yunnanenses extract 0.3~0.4% of Rhizoma Fagopyri Dibotryis extract is low
Fructooligosaccharides 1~1.2%, amphoteric surfactant 5~8%, anion surfactant 2~3%, nonionic surfactant 1
~2%, foam stabilizer 0.2~0.5%, deionized water supplies 100%；Wherein, Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract with hydroxyl
Propyl-beta-cyclodextrin embeds, and buckeye-bletilla striata composite extract is coated with collagen film.
Preferably, the buckeye-bletilla striata composite extract extracts obtain by the following method：By buckeye and in vain
Splendid achnatherum is dry, co-grinding sieving, obtains coarse powder, and gained coarse powder is used CO2Supercritical fluid extraction, separating and collecting volatility has
Effect ingredient and fat-soluble active ingredient, the two mix to obtain the final product.
It is further preferred that CO2The extraction temperature of supercritical fluid extraction is 40~50 DEG C, extracting pressure for 30~
40MPa, when extraction time is 2~3 small, CO2Flow velocity is 20~25L/h；The separation is using 40~50 DEG C of temperature, pressure 5
~8MPa.
Preferably, the cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Preferably, the Rhizoma Fagopyri Dibotryis extract extracts obtain by the following method：By the rhizome drying of cymose buckwheat rhizome, powder
Broken sieving, obtains coarse powder, and gained coarse powder is placed in pressure difference extractor, 3~4 DEG C of condensed water temperature；It vacuumizes：In 30~40 seconds
Pressure difference extractor is evacuated to -50~-100MPa, is kept for 2~5 minutes, 15 DEG C of deionized water is sprayed into and extracts；Subtract true
It is empty：Purified compressed air is passed through, pressure in pressure difference extractor was made to rise to 0MPa in 1~3 minute；Pressurization：Continue to be passed through
Purified compressed air makes the pressure in pressure difference extractor reach 3MPa, is kept for 2~5 minutes；Decompression：Stop pressurization, again
Vacuumizing makes pressure in pressure difference extractor be down to 0Mpa；The process repeated several times of decompression will be evacuated to, pass through centrifugation afterwards
Carry out separation of solid and liquid, centrifugate filtering, filtrate concentration, obtain concentrate, make its 25 DEG C relative density be 1.02；Wherein, it is golden
Buckwheat and the mass volume ratio of deionized water are 1g：20mL.
Preferably, the Eutrema yunnanense extract extracts by the following method obtains：Through at a high speed after Eutrema yunnanense is dried
Pulverizer crushes, using the mass volume ratio that n-hexane is Extraction solvent , Eutrema yunnanenses and n-hexane as 1g：20mL, microwave power
750W is extracted 10 minutes, and n-hexane is recovered under reduced pressure to get powdered Eutrema yunnanenses extract in filtering, extracting solution.
Preferably, the quality of the hydroxypropyl-β-cyclodextrin is the 5 of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass
~8 times.
Preferably, the collagen film is to be formed a film and obtained, collagen liquid including collagen using collagen liquid
With deionized water two parts, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid are Horse chest Nut P.Es and white
4~5 times of splendid achnatherum extract gross mass.
It is further preferred that the preparation method of the collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 2~3 times
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 12~20 of raw material weight is small with clear water to neutrality；Then with 5~8 times of originals
The 0.05mol/L hydrochloric acid solutions stirring of material weight impregnate 2~3 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen
Albumen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Preferably, the amphoteric surfactant is selected from Cocoamidopropyl betaine or dodecyldimethylamine oxide
Any one of；The anion surfactant is selected from any one of polyoxyethylene ether sulfate or isethionate；
The nonionic surfactant is selected from any one of Polysorbate 20 or coconut oil fatty acid monoethanolamide.
Preferably, the phytosterol is the phytosterol of soybean extraction.
Preferably, the foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 70~80 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80~85 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 30~40 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 70~80 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling adds in buckeye-bletilla striata composite extract, the hydroxypropyl of collagen film cladding to 45~50 DEG C
The Rhizoma Fagopyri Dibotryis extract of group-beta-cyclodextrin embedding is He Eutrema yunnanense extract, stirs 20~30 minutes, then add in C phases, continue to stir
Mix 1~2 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
Preferably, in step (5), buckeye-bletilla striata composite extract of collagen film cladding is by the following method
It is prepared：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 30~40 minutes, then
Under the conditions of -40 DEG C, 1.3Pa it is dry 24 it is small when to get.
Preferably, in step (5), the Rhizoma Fagopyri Dibotryis extract of hydroxypropyl-β-cyclodextrin embedding is He Eutrema yunnanense extract is logical
Cross what following methods were prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 2~3 times of weight, then while stirring
Rhizoma Fagopyri Dibotryis extract is added in He Eutrema yunnanense extract, continue stirring 20~40 minutes to get.
Coarse powder grain size of the present invention is 0.3~0.5mm.
The beneficial effects of the invention are as follows：
1st, shower cream of the invention introduces antibacterial components and moisturizing component, so as to assign shower cream good anti-microbial property
And performance of keeping humidity, without additionally adding preservative again.Antibacterial components include Rhizoma Fagopyri Dibotryis extract, Eutrema yunnanenses extract and oligomeric fruit
Sugar, Rhizoma Fagopyri Dibotryis extract avoid natural extract from directly being connect with skin He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin
It touches and causes to stimulate discomfort, slowly release plays antibacterial action.Moisturizing component includes L-Pyrrolidone Carboxylic Acid sodium, the buckeye-bletilla striata
Composite extract, cactus juice and phytosterol, buckeye-bletilla striata composite extract are coated with collagen film, avoid sieve Suo
Son-bletilla striata composite extract is in direct contact with the skin to be caused to stimulate discomfort, and collagen has good compatible with human skin
Property, buckeye-bletilla striata composite extract is slowly discharged, plays better moisture-keeping function.
2nd, the rhizome extract of cymose buckwheat rhizome , Eutrema yunnanenses extract inhibited to various bacteria, fungi etc. is to more
Kind pathogenic bacteria have very strong killing effect, and oligofructose is a kind of natural active matter, effectively inhibit harmful bacteria, fungi etc.
Growth, three's collective effect kills pathogenic bacteria, while inhibits bacteria, the growth once again of fungi etc., plays the work of long-term antibacterial
With.
3rd, L-Pyrrolidone Carboxylic Acid sodium is a kind of high moisturizer of security, to skin almost without irritation, celestial being
It slaps in juice, buckeye and the bletilla striata rich in colloid substance, gluey film can be formed in skin surface, play moisture-keeping function, plant steroid
Alcohol has skin very high permeability, and more than moisturizing ingredient can be guided to penetrate into skin and be attached to skin surface, to play more
Good moisture-keeping function.
4th, hydroxypropyl-β-cyclodextrin and collagen component can temporarily form thin film in skin surface, reduce
Moisture of skin scatters and disappears, and plays the role of locking moisture, moisturizing.
5th, in the preparation, A phases (various surfactants, foam stabilizer and portions of de-ionized water) are first made respectively, B phases (are planted
Object sterol) and C phases (L-Pyrrolidone Carboxylic Acid sodium, oligofructose, cactus juice and remaining deionized water), then A phases are mixed with B phases
Close so that phytosterol in system uniformly disperse, be eventually adding collagen film cladding buckeye-bletilla striata composite extract,
The Rhizoma Fagopyri Dibotryis extract of hydroxypropyl-β-cyclodextrin embedding is He Eutrema yunnanense extract, C phases, contribute to each component equal in system
It is even scattered, ensure the uniformity and stability of product.
Specific embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's all other embodiments obtained without making creative work belong to the model that the present invention protects
It encloses.
Embodiment 1
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5%, buckeye-bletilla striata composite extract 0.2%, cactus juice 1.5%, plant steroid
Alcohol 0.2%, 0.5% , Eutrema yunnanenses extract 0.3% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1%, amphoteric surfactant 5% are cloudy
Ionic surface active agent 2%, nonionic surfactant 1%, foam stabilizer 0.2%, deionized water supplies 100%；Wherein, Jin Qiao
Wheat extract is He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin, and buckeye-bletilla striata composite extract is with collagen film
Cladding.
Buckeye-bletilla striata composite extract is obtained by mixing using Horse chest Nut P.E and bletilla striata extract, and buckeye carries
Object is taken, purchased from Xi'an Yuan Sen bio tech ltd, bletilla striata extract, purchased from Shaanxi Si Nuote Bioisystech Co., Ltd.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract, purchased from Shaanxi Bo Lin Bioisystech Co., Ltd, Eutrema yunnanense extract, purchased from the gloomy Ran Sheng in Xi'an
Object Engineering Co., Ltd.
The quality of hydroxypropyl-β-cyclodextrin is 5 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
4 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 2 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 12 of material weight is small with clear water to neutrality；Then weighed with 5 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 2 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is polyoxyethylene ether sulfuric acid
Salt；Nonionic surfactant is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 70 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 30 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 70 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling is to 45 DEG C, add in buckeye-bletilla striata composite extract of collagen film cladding, hydroxy propyl-Beta-
The Rhizoma Fagopyri Dibotryis extract of cyclodextrin embedding and Eutrema yunnanense extract, stir 20 minutes, then add in C phases, continue stirring 1 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 30 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (5), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 2 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 20 minutes to get.
Embodiment 2
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.8%, buckeye-bletilla striata composite extract 0.3%, cactus juice 2%, phytosterol
0.3%, 0.8% , Eutrema yunnanenses extract 0.4% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1.2%, amphoteric surfactant 8%, the moon
Ionic surface active agent 3%, nonionic surfactant 2%, foam stabilizer 0.5%, deionized water supplies 100%；Wherein, Jin Qiao
Wheat extract is He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin, and buckeye-bletilla striata composite extract is with collagen film
Cladding.
Buckeye-bletilla striata composite extract is obtained by mixing using Horse chest Nut P.E and bletilla striata extract, and buckeye carries
Object is taken, purchased from Xi'an Yuan Sen bio tech ltd, bletilla striata extract, purchased from Shaanxi Si Nuote Bioisystech Co., Ltd.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract, purchased from Shaanxi Bo Lin Bioisystech Co., Ltd, Eutrema yunnanense extract, purchased from the gloomy Ran Sheng in Xi'an
Object Engineering Co., Ltd.
The quality of hydroxypropyl-β-cyclodextrin is 8 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
5 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 3 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 20 of material weight is small with clear water to neutrality；Then weighed with 8 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 3 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is dodecyldimethylamine oxide；Anion surfactant is isethionate；
Nonionic surfactant is coconut oil fatty acid monoethanolamide.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 80 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 85 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 40 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 80 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling is to 50 DEG C, add in buckeye-bletilla striata composite extract of collagen film cladding, hydroxy propyl-Beta-
The Rhizoma Fagopyri Dibotryis extract of cyclodextrin embedding and Eutrema yunnanense extract, stir 30 minutes, then add in C phases, continue stirring 2 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 40 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (5), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 3 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 40 minutes to get.
Embodiment 3
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5%, buckeye-bletilla striata composite extract 0.3%, cactus juice 1.5%, plant steroid
Alcohol 0.3%, 0.5% , Eutrema yunnanenses extract 0.4% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1%, amphoteric surfactant 8% are cloudy
Ionic surface active agent 2%, nonionic surfactant 2%, foam stabilizer 0.2%, deionized water supplies 100%；Wherein, Jin Qiao
Wheat extract is He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin, and buckeye-bletilla striata composite extract is with collagen film
Cladding.
Buckeye-bletilla striata composite extract extracts obtain by the following method：By buckeye and bletilla striata drying, mixing
It pulverizes and sieves, obtains coarse powder, gained coarse powder is used into CO2Supercritical fluid extraction separates and collects volatile effective component and fat
Soluble active principals, the two mix to obtain the final product.CO2The extraction temperature of supercritical fluid extraction is 50 DEG C, extracting pressure 30MPa,
When extraction time is 3 small, CO2Flow velocity is 20L/h；The separation is using temperature 50 C, pressure 5MPa.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract extracts obtain by the following method：It by the rhizome drying of cymose buckwheat rhizome, pulverizes and sieves, obtains
Gained coarse powder is placed in pressure difference extractor by coarse powder, 4 DEG C of condensed water temperature；It vacuumizes：Pressure difference extractor is vacuumized in 30 seconds
It to -100MPa, is kept for 2 minutes, sprays into 15 DEG C of deionized water and extract；Subtract vacuum：Purified compressed air is passed through,
Pressure in pressure difference extractor is made to rise to 0MPa in 3 minutes；Pressurization：Continue to be passed through purified compressed air, make pressure difference extractor
Interior pressure reaches 3MPa, is kept for 2 minutes；Decompression：Stop pressurization, vacuumize is down to pressure in pressure difference extractor again
0Mpa；The process repeated several times of decompression will be evacuated to, carry out separation of solid and liquid by centrifuging afterwards, centrifugate filtering, filtrate
Concentration, obtain concentrate, make its 25 DEG C relative density be 1.02；Wherein, the mass volume ratio of cymose buckwheat rhizome and deionized water is
1g：20mL.
Eutrema yunnanense extract extracts obtain by the following method：It is crushed after Eutrema yunnanense is dried through high speed disintegrator,
Using the mass volume ratio that n-hexane is Extraction solvent , Eutrema yunnanenses and n-hexane as 1g：20mL, microwave power 750W extract 10 points
N-hexane is recovered under reduced pressure to get powdered Eutrema yunnanenses extract in clock, filtering, extracting solution.
The quality of hydroxypropyl-β-cyclodextrin is 8 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
4 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 3 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 12 of material weight is small with clear water to neutrality；Then weighed with 8 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 2 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is isethionate；It is non-
Ionic surface active agent is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 80 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 40 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 70 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling is to 50 DEG C, add in buckeye-bletilla striata composite extract of collagen film cladding, hydroxy propyl-Beta-
The Rhizoma Fagopyri Dibotryis extract of cyclodextrin embedding and Eutrema yunnanense extract, stir 20 minutes, then add in C phases, continue stirring 2 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 30 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (5), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 3 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 20 minutes to get.
Embodiment 4
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.8%, buckeye-bletilla striata composite extract 0.2%, cactus juice 2%, phytosterol
0.2%, 0.8% , Eutrema yunnanenses extract 0.3% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1.2%, amphoteric surfactant 5%, the moon
Ionic surface active agent 3%, nonionic surfactant 1%, foam stabilizer 0.5%, deionized water supplies 100%；Wherein, Jin Qiao
Wheat extract is He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin, and buckeye-bletilla striata composite extract is with collagen film
Cladding.
Buckeye-bletilla striata composite extract extracts obtain by the following method：By buckeye and bletilla striata drying, mixing
It pulverizes and sieves, obtains coarse powder, gained coarse powder is used into CO2Supercritical fluid extraction separates and collects volatile effective component and fat
Soluble active principals, the two mix to obtain the final product.CO2The extraction temperature of supercritical fluid extraction is 40 DEG C, extracting pressure 40MPa,
When extraction time is 2 small, CO2Flow velocity is 25L/h；The separation is using 40 DEG C of temperature, pressure 8MPa.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract extracts obtain by the following method：It by the rhizome drying of cymose buckwheat rhizome, pulverizes and sieves, obtains
Gained coarse powder is placed in pressure difference extractor by coarse powder, 3 DEG C of condensed water temperature；It vacuumizes：Pressure difference extractor is vacuumized in 40 seconds
It to -50MPa, is kept for 5 minutes, sprays into 15 DEG C of deionized water and extract；Subtract vacuum：Purified compressed air is passed through, 1
In minute pressure in pressure difference extractor is made to rise to 0MPa；Pressurization：Continue to be passed through purified compressed air, make in pressure difference extractor
Pressure reach 3MPa, kept for 5 minutes；Decompression：Stop pressurization, vacuumize makes pressure in pressure difference extractor be down to 0Mpa again；
The process repeated several times of decompression will be evacuated to, carry out separation of solid and liquid by centrifuging afterwards, centrifugate filtering, filtrate concentration,
Concentrate, make its 25 DEG C relative density be 1.02；Wherein, the mass volume ratio of cymose buckwheat rhizome and deionized water is 1g：
20mL。
Eutrema yunnanense extract extracts obtain by the following method：It is crushed after Eutrema yunnanense is dried through high speed disintegrator,
Using the mass volume ratio that n-hexane is Extraction solvent , Eutrema yunnanenses and n-hexane as 1g：20mL, microwave power 750W extract 10 points
N-hexane is recovered under reduced pressure to get powdered Eutrema yunnanenses extract in clock, filtering, extracting solution.
The quality of hydroxypropyl-β-cyclodextrin is 5 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
5 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 2 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 20 of material weight is small with clear water to neutrality；Then weighed with 5 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 3 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is dodecyldimethylamine oxide；Anion surfactant is polyoxyethylene ether sulfuric acid
Salt；Nonionic surfactant is coconut oil fatty acid monoethanolamide.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 70 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 85 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 30 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 80 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling is to 45 DEG C, add in buckeye-bletilla striata composite extract of collagen film cladding, hydroxy propyl-Beta-
The Rhizoma Fagopyri Dibotryis extract of cyclodextrin embedding and Eutrema yunnanense extract, stir 30 minutes, then add in C phases, continue stirring 1 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 40 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (5), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 2 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 40 minutes to get.
Embodiment 5
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.6%, buckeye-bletilla striata composite extract 0.25%, cactus juice 1.8%, plant
Sterol 0.25%, 0.7% , Eutrema yunnanenses extract 0.35% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1~1.1%, amophoteric surface active
Agent 7%, anion surfactant 2.5%, nonionic surfactant 1.5%, foam stabilizer 0.3%, deionized water is supplied
100%；Wherein, He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin, buckeye-bletilla striata is compound to be carried Rhizoma Fagopyri Dibotryis extract
Object is taken to be coated with collagen film.
Buckeye-bletilla striata composite extract extracts obtain by the following method：By buckeye and bletilla striata drying, mixing
It pulverizes and sieves, obtains coarse powder, gained coarse powder is used into CO2Supercritical fluid extraction separates and collects volatile effective component and fat
Soluble active principals, the two mix to obtain the final product.CO2The extraction temperature of supercritical fluid extraction is 45 DEG C, extracting pressure 35MPa,
When extraction time is 2.5 small, CO2Flow velocity is 22L/h；The separation is using temperature 45 C, pressure 7MPa.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract extracts obtain by the following method：It by the rhizome drying of cymose buckwheat rhizome, pulverizes and sieves, obtains
Gained coarse powder is placed in pressure difference extractor by coarse powder, 4 DEG C of condensed water temperature；It vacuumizes：Pressure difference extractor is vacuumized in 35 seconds
It to -80MPa, is kept for 3 minutes, sprays into 15 DEG C of deionized water and extract；Subtract vacuum：Purified compressed air is passed through, 2
In minute pressure in pressure difference extractor is made to rise to 0MPa；Pressurization：Continue to be passed through purified compressed air, make in pressure difference extractor
Pressure reach 3MPa, kept for 4 minutes；Decompression：Stop pressurization, vacuumize makes pressure in pressure difference extractor be down to 0Mpa again；
The process repeated several times of decompression will be evacuated to, carry out separation of solid and liquid by centrifuging afterwards, centrifugate filtering, filtrate concentration,
Concentrate, make its 25 DEG C relative density be 1.02；Wherein, the mass volume ratio of cymose buckwheat rhizome and deionized water is 1g：
20mL。
Eutrema yunnanense extract extracts obtain by the following method：It is crushed after Eutrema yunnanense is dried through high speed disintegrator,
Using the mass volume ratio that n-hexane is Extraction solvent , Eutrema yunnanenses and n-hexane as 1g：20mL, microwave power 750W extract 10 points
N-hexane is recovered under reduced pressure to get powdered Eutrema yunnanenses extract in clock, filtering, extracting solution.
The quality of hydroxypropyl-β-cyclodextrin is 6 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
4 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 3 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 15 of material weight is small with clear water to neutrality；Then weighed with 6 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 3 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is isethionate；It is non-
Ionic surface active agent is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 75 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 82 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 35 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 75 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling is to 48 DEG C, add in buckeye-bletilla striata composite extract of collagen film cladding, hydroxy propyl-Beta-
The Rhizoma Fagopyri Dibotryis extract of cyclodextrin embedding and Eutrema yunnanense extract, stir 25 minutes, then add in C phases, continue stirring 2 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 35 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (5), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 3 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 30 minutes to get.
Comparative example 1
A kind of shower cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5%, cactus juice 1.5%, phytosterol 0.2%, Rhizoma Fagopyri Dibotryis extract 0.5%,
Eutrema yunnanense extract 0.3%, oligofructose 1%, amphoteric surfactant 5%, anion surfactant 2%, nonionic table
Face activating agent 1%, foam stabilizer 0.2%, deionized water supplies 100%；Wherein, Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract with hydroxyl
Propyl-beta-cyclodextrin embeds.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract, purchased from Shaanxi Bo Lin Bioisystech Co., Ltd, Eutrema yunnanense extract, purchased from the gloomy Ran Sheng in Xi'an
Object Engineering Co., Ltd.
The quality of hydroxypropyl-β-cyclodextrin is 5 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is polyoxyethylene ether sulfuric acid
Salt；Nonionic surfactant is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned shower cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 70 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 30 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 70 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling adds in the Rhizoma Fagopyri Dibotryis extract of hydroxypropyl-β-cyclodextrin embedding He Eutrema yunnanense extracts to 45 DEG C
Object, stir 20 minutes, then add in C phases, continue stirring 1 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 2 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 20 minutes to get.
Comparative example 2
A kind of shower cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5%, buckeye-bletilla striata composite extract 0.2%, cactus juice 1.5%, plant steroid
0.2% , Eutrema yunnanenses extract 0.3% of alcohol, oligofructose 1%, amphoteric surfactant 5%, anion surfactant 2%,
Nonionic surfactant 1%, foam stabilizer 0.2%, deionized water supplies 100%；Wherein , Eutrema yunnanenses extract with hydroxypropyl-
Beta-cyclodextrin embeds, and buckeye-bletilla striata composite extract is coated with collagen film.
Buckeye-bletilla striata composite extract is obtained by mixing using Horse chest Nut P.E and bletilla striata extract, and buckeye carries
Object is taken, purchased from Xi'an Yuan Sen bio tech ltd, bletilla striata extract, purchased from Shaanxi Si Nuote Bioisystech Co., Ltd.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Eutrema yunnanense extract, purchased from Xi'an Sen Ran bioengineering Co., Ltd.
5 times of the quality Shi Eutrema yunnanense extract gross masses of hydroxypropyl-β-cyclodextrin.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
4 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 2 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 12 of material weight is small with clear water to neutrality；Then weighed with 5 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 2 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is polyoxyethylene ether sulfuric acid
Salt；Nonionic surfactant is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned shower cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 70 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 30 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 70 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling is to 45 DEG C, add in buckeye-bletilla striata composite extract of collagen film cladding, hydroxy propyl-Beta-
The Eutrema yunnanense extract of cyclodextrin embedding, stir 20 minutes, then add in C phases, continue stirring 1 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
In step (5), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 30 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (5), hydroxypropyl-β-cyclodextrin embedding Eutrema yunnanense extracts are prepared by the following method to obtain：
Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 2 times of weight, then adds in Eutrema yunnanense extract while stirring, continue to stir
Mix 20 minutes to get.
Comparative example 3
A kind of shower cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5%, buckeye-bletilla striata composite extract 0.2%, cactus juice 1.5%, plant steroid
Alcohol 0.2%, 0.5% , Eutrema yunnanenses extract 0.3% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1%, amphoteric surfactant 5% are cloudy
Ionic surface active agent 2%, nonionic surfactant 1%, foam stabilizer 0.2%, deionized water supplies 100%.
Buckeye-bletilla striata composite extract is obtained by mixing using Horse chest Nut P.E and bletilla striata extract, and buckeye carries
Object is taken, purchased from Xi'an Yuan Sen bio tech ltd, bletilla striata extract, purchased from Shaanxi Si Nuote Bioisystech Co., Ltd.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract, purchased from Shaanxi Bo Lin Bioisystech Co., Ltd, Eutrema yunnanense extract, purchased from the gloomy Ran Sheng in Xi'an
Object Engineering Co., Ltd.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is polyoxyethylene ether sulfuric acid
Salt；Nonionic surfactant is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned shower cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And 2/3 the deionized water of formula ratio be heated to 70 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80 DEG C of heat preservations are dissolved into obtain B phases；
(3) the L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirred
Cactus juice is added in after mixing dissolving, supersonic oscillations 30 minutes obtain C phases；
(4) B phases are uniformly mixed with A phases, and 70 DEG C of isothermal holdings are until solution is clarified；
(5) slow cooling adds in buckeye-bletilla striata composite extract of collagen film cladding, cymose buckwheat rhizome carries to 45 DEG C
Take object and Eutrema yunnanense extract, stir 20 minutes, then add in C phases, continue stirring 1 it is small when；
(6) 40 DEG C are cooled to, discharge to get.
Comparative example 4
A kind of moisturizing antibacterial bath cream is made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5%, buckeye-bletilla striata composite extract 0.2%, cactus juice 1.5%, plant steroid
Alcohol 0.2%, 0.5% , Eutrema yunnanenses extract 0.3% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1%, amphoteric surfactant 5% are cloudy
Ionic surface active agent 2%, nonionic surfactant 1%, foam stabilizer 0.2%, deionized water supplies 100%；Wherein, Jin Qiao
Wheat extract is He Eutrema yunnanense extract is embedded with hydroxypropyl-β-cyclodextrin, and buckeye-bletilla striata composite extract is with collagen film
Cladding.
Buckeye-bletilla striata composite extract is obtained by mixing using Horse chest Nut P.E and bletilla striata extract, and buckeye carries
Object is taken, purchased from Xi'an Yuan Sen bio tech ltd, bletilla striata extract, purchased from Shaanxi Si Nuote Bioisystech Co., Ltd.
Cactus juice is mucus obtained by the fleshy stem of cactus is squeezed.
Rhizoma Fagopyri Dibotryis extract, purchased from Shaanxi Bo Lin Bioisystech Co., Ltd, Eutrema yunnanense extract, purchased from the gloomy Ran Sheng in Xi'an
Object Engineering Co., Ltd.
The quality of hydroxypropyl-β-cyclodextrin is 5 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
Collagen film is to be formed a film and obtained, collagen liquid including collagen and deionized water two using collagen liquid
Part, the mass volume ratio of the two is 1g：30mL, the quality of collagen liquid is Horse chest Nut P.E and the total matter of bletilla striata extract
4 times of amount.The preparation method of collagen liquid is as follows：
(A) extraction of thick collagen：Will be a kind of as raw material in fish-bone, fish-skin, fish scale or fish muscle, utilize 2 times of originals
It is rinsed after when the 0.05mol/L sodium hydroxide solutions immersion 12 of material weight is small with clear water to neutrality；Then weighed with 5 times of raw materials
The stirring of 0.05mol/L hydrochloric acid solutions impregnate 2 it is small when after rinsed with clear water to neutral and blend and be prepared into thick collagen；
(B) modulation of collagen liquid：Deionized water is added in thick collagen, 80 DEG C of extractions filter out insoluble matter to obtain the final product,
The thick collagen and the mass volume ratio of deionized water are 1g：30mL.
Amphoteric surfactant is Cocoamidopropyl betaine；Anion surfactant is polyoxyethylene ether sulfuric acid
Salt；Nonionic surfactant is Polysorbate 20.
Foam stabilizer is polyethylene glycol -14M.
A kind of preparation method of above-mentioned moisturizing antibacterial bath cream, comprises the following steps：
(1) by the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer
And deionized water is heated to 70 DEG C, dissolving obtains A phases；
(2) heating plant sterols to 80 DEG C of heat preservations are dissolved into obtain B phases；
(3) B phases are uniformly mixed with A phases, and 70 DEG C of isothermal holdings are until solution is clarified；
(4) slow cooling adds in L-Pyrrolidone Carboxylic Acid sodium, oligofructose, cactus juice collagen film bag to 45 DEG C
The buckeye covered-bletilla striata composite extract, the Rhizoma Fagopyri Dibotryis extract of hydroxypropyl-β-cyclodextrin embedding are He Eutrema yunnanense extract, is stirred
Mix 20 minutes, then add in C phases, continue stirring 1 it is small when；
(5) 40 DEG C are cooled to, discharge to get.
In step (4), buckeye-bletilla striata composite extract of collagen film cladding is to be prepared by the following method to obtain
's：Buckeye-bletilla striata composite extract is added in collagen liquid, supersonic oscillations 30 minutes, then at -40 DEG C, 1.3Pa
Under the conditions of it is dry 24 it is small when to get.
In step (4), the Rhizoma Fagopyri Dibotryis extract and Eutrema yunnanense extract of hydroxypropyl-β-cyclodextrin embedding are by with lower section
What method was prepared：Hydroxypropyl-β-cyclodextrin is dissolved in the deionized water of 2 times of weight, then adds in cymose buckwheat rhizome while stirring
Extract He Eutrema yunnanense extract, continue stirring 20 minutes to get.
Test example
1st, stability
The shower cream of Examples 1 to 5 and comparative example 1~4 is respectively placed under the conditions of -3 DEG C, 30 DEG C 48 it is small when, it is real
The shower cream for applying example 1~5 and comparative example 1~3 does not occur being layered, precipitate, crystallize or changing the variations such as color, illustrates to have good
Good stability；The shower cream of comparative example 4 precipitates under two temperature conditionss, illustrates that stability is poor.
2nd, antibacterial effect
Staphylococcus aureus, Candida albicans are inoculated in respectively on agar plate nutrition fluid level, when inoculation is uniform
It gathers, the sterile circular filter paper piece of tweezer sprays the shower cream of Examples 1 to 5 or comparative example 2~4 respectively, until complete wetting,
It is attached on the agar plate nutrition fluid level of inoculated bacteria, fungi etc..Agar plate is placed in 37 DEG C of incubator, incubated
24 it is small when.Measure the diameter of antibacterial ring size.It measures 3 times and is averaged.It the results are shown in Table 1.
The inhibition zone diameter of 1. different disposal liquid of table compares
As it can be seen from table 1 the shower cream of Examples 1 to 5 has relatively by force staphylococcus aureus and Candida albicans
Inhibitory action.Comparative example 2 omits Rhizoma Fagopyri Dibotryis extract, and anti-microbial property is substantially deteriorated；Comparative example 3 omits cladding component,
The antibacterial effect for affecting antimicrobial component plays；Not previously prepared C phases in comparative example 4 but C phase components are directly added into, take a shower
Reveal uniformity variation and then influence antibacterial effect.
3rd, moistening effect
80 skin healths, the subject without skin disease allergies are chosen, at 25~28 years old age, men and women is fifty-fifty, random point
For 8 groups, every group of men and women's number is identical, delimits test zone, respectively using Examples 1 to 5 or comparative example 1, comparative example 3 and comparison
The shower cream of example 4, the moisture content of skin (average value) after being tested respectively using moisture tester when washing is preceding and washing 2 is small, meter
Calculating water content increases percentage, the results are shown in Table 2.
Test zone is subject's right hand inner forearm 5cm2Position.
2. moistening effect of table compares
As it can be seen from table 1 the shower cream of Examples 1 to 5 has splendid moistening effect.Comparative example 1 omits sieve Suo
Son-bletilla striata composite extract, anti-microbial property are substantially deteriorated；Comparative example 3 omits cladding component, affects the antibacterial of moisturizing ingredient
Effect plays；Not previously prepared C phases in comparative example 4 but C phase components are directly added into, shower cream uniformity be deteriorated so that influence
Moistening effect.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (10)
1. a kind of moisturizing antibacterial bath cream, which is characterized in that be made of the raw material of following weight percent：
L-Pyrrolidone Carboxylic Acid sodium 0.5~0.8%, buckeye-bletilla striata composite extract 0.2~0.3%, cactus juice 1.5~2%,
Phytosterol 0.2~0.3%, 0.5~0.8% , Eutrema yunnanenses extract 0.3~0.4% of Rhizoma Fagopyri Dibotryis extract, oligofructose 1~
1.2%, amphoteric surfactant 5~8%, anion surfactant 2~3%, nonionic surfactant 1~2%, foam stabilizer
0.2~0.5%, deionized water supplies 100%；Wherein, Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract with hydroxypropyl-β-cyclodextrin bag
It buries, buckeye-bletilla striata composite extract is coated with collagen film.
2. the buckeye-bletilla striata composite extract extracts obtain by the following method：Buckeye and the bletilla striata is dry, mixed
Conjunction pulverizes and sieves, and obtains coarse powder, and gained coarse powder is used CO2Supercritical fluid extraction, separate and collect volatile effective component and
Fat-soluble active ingredient, the two mix to obtain the final product.
3. a kind of moisturizing antibacterial bath cream according to claim 1, which is characterized in that the Rhizoma Fagopyri Dibotryis extract is to pass through
What following methods extracted：It by the rhizome drying of cymose buckwheat rhizome, pulverizes and sieves, obtains coarse powder, gained coarse powder is placed in pressure difference carries
It takes in device, 3~4 DEG C of condensed water temperature；It vacuumizes：Pressure difference extractor is evacuated to -50~-100MPa in 30~40 seconds, is protected
It holds 2~5 minutes, sprays into 15 DEG C of deionized water and extract；Subtract vacuum：Purified compressed air is passed through, at 1~3 minute
Pressure in pressure difference extractor is inside made to rise to 0MPa；Pressurization：Continue to be passed through purified compressed air, make the pressure in pressure difference extractor
Power reaches 3MPa, is kept for 2~5 minutes；Decompression：Stop pressurization, vacuumize makes pressure in pressure difference extractor be down to 0Mpa again；It will
The process repeated several times of decompression are evacuated to, carry out separation of solid and liquid by centrifuging afterwards, centrifugate filtering, filtrate concentration obtains
Concentrate, make its 25 DEG C relative density be 1.02；Wherein, the mass volume ratio of cymose buckwheat rhizome and deionized water is 1g：20mL.
4. a kind of moisturizing antibacterial bath cream according to claim 1, which is characterized in that the Eutrema yunnanense extract is to pass through
What following methods extracted：Crushed after Eutrema yunnanense is dried through high speed disintegrator, using n-hexane as Extraction solvent, Eutrema yunnanense and
The mass volume ratio of n-hexane is 1g：20mL, microwave power 750W, extract 10 minutes, filtering, extracting solution be recovered under reduced pressure just oneself
Alkane is to get powdered Eutrema yunnanenses extract.
5. a kind of moisturizing antibacterial bath cream according to claim 1, which is characterized in that the hydroxypropyl-β-cyclodextrin
Quality is 5~8 times of Rhizoma Fagopyri Dibotryis extract He Eutrema yunnanense extract gross mass.
6. a kind of moisturizing antibacterial bath cream according to claim 1, which is characterized in that the collagen film is to utilize glue
Former protein liquid forms a film and obtains, collagen liquid including collagen and deionized water two parts, and the mass volume ratio of the two is 1g：
30mL, the quality of collagen liquid are 4~5 times of Horse chest Nut P.E and bletilla striata extract gross mass.
7. a kind of moisturizing antibacterial bath cream according to claim 1, which is characterized in that the amphoteric surfactant is selected from
Any one of Cocoamidopropyl betaine or dodecyldimethylamine oxide；The anion surfactant is selected from poly-
Any one of ethylene oxide ether sulfate or isethionate；The nonionic surfactant is selected from Polysorbate 20 or coconut palm
Any one of seed oil fatty monoethanol amide.
8. a kind of preparation method of moisturizing antibacterial bath cream any one of claim 1~7, which is characterized in that including with
Lower step：
（1）By the amphoteric surfactant of formula ratio, nonionic surfactant, anion surfactant, foam stabilizer and
The deionized water of 2/3 formula ratio is heated to 70~80 DEG C, and dissolving obtains A phases；
（2）Heating plant sterols to 80~85 DEG C of heat preservations are dissolved into obtain B phases；
（3）The L-Pyrrolidone Carboxylic Acid sodium and oligofructose of formula ratio are added in the deionized water of remaining formula ratio, stirring is molten
Cactus juice is added in after solution, supersonic oscillations 30~40 minutes obtain C phases；
（4）B phases are uniformly mixed with A phases, and 70~80 DEG C of isothermal holdings are until solution is clarified；
（5）Slow cooling to 45~50 DEG C, add in collagen film cladding buckeye-bletilla striata composite extract, hydroxy propyl-Beta-
The Rhizoma Fagopyri Dibotryis extract of cyclodextrin embedding stirs 20~30 minutes He Eutrema yunnanense extract, then adds in C phases, continue stirring 1~
2 it is small when；
（6）Be cooled to 40 DEG C, discharge to get.
9. preparation method according to claim 7, which is characterized in that step（5）In, sieve Suo of collagen film cladding
Son-bletilla striata composite extract is prepared by the following method to obtain：Buckeye-bletilla striata composite extract is added in into collagen
In liquid, supersonic oscillations 30~40 minutes, then under the conditions of -40 DEG C, 1.3Pa it is dry 24 it is small when to get.
10. preparation method according to claim 8, which is characterized in that step（5）In, hydroxypropyl-β-cyclodextrin embedding
Rhizoma Fagopyri Dibotryis extract is He Eutrema yunnanense extract is prepared by the following method to obtain：Hydroxypropyl-β-cyclodextrin is dissolved in 2~3
In the deionized water of times weight, Rhizoma Fagopyri Dibotryis extract is then added in while stirring He Eutrema yunnanense extract, continues stirring 20~40
Minute to get.
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| CN112220735A (en) * | 2020-11-19 | 2021-01-15 | 聂绪明 | EM (effective microorganism) fungus shower gel and preparation method thereof |
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| CN112932990A (en) * | 2021-04-15 | 2021-06-11 | 广州樊文花化妆品有限公司 | Anti-aging composition and preparation method and application thereof |
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