CN108066228B - Moisturizing antibacterial shower gel and preparation method thereof - Google Patents
Moisturizing antibacterial shower gel and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention provides moisturizing antibacterial shower gel and a preparation method thereof, wherein the shower gel is provided with an antibacterial component and a moisturizing component, so that the shower gel is endowed with good antibacterial performance and moisturizing performance, no preservative is required to be additionally added, the antibacterial component comprises a wild buckwheat rhizome extract, a behen extract and fructo-oligosaccharide, the wild buckwheat rhizome extract and the behen extract are embedded by hydroxypropyl- β -cyclodextrin, stimulation and discomfort caused by direct contact of a natural extract and skin are avoided, and the antibacterial effect is exerted by slow release.
Description
Technical Field
The invention relates to the technical field of daily chemical washing products, in particular to moisturizing and antibacterial shower gel and a preparation method thereof.
Background
The shower gel is a common daily chemical washing product for bathing and belongs to a liquid cleaning agent. In recent years, with the improvement of the living standard of people, the shower gel gradually replaces the perfumed soap to become the first choice of the bathing articles of people. Meanwhile, the requirements of people on the shower gel are not limited to skin cleaning, but higher requirements are put forward, such as moisturizing performance, antibacterial performance and the like.
Sweat and skin surface scurf discharged by a human body are combined with dust in the air to form dirt, the dirt is accumulated on the surface of the skin, a large number of microorganisms including a large number of pathogenic microorganisms are continuously accumulated on the surface of the dirt, and serious threats are brought to the health of the human body.
In addition, in order to improve the cleaning power and the oil removal capability, a large amount of components such as a surfactant with strong alkalinity, a foaming agent, a soap base and the like are added into the traditional shower gel, but the skin of a human body is weakly acidic, so that the skin can be stimulated and a sebum membrane can be damaged after the traditional shower gel is used for a long time, and the skin is easily damaged by the outside.
Disclosure of Invention
The invention aims to provide a moisturizing antibacterial shower gel and a preparation method thereof, and the shower gel comprises the following components; good moisture retention and antibacterial performance.
In order to achieve the purpose, the invention is realized by the following scheme:
the moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.5-0.8% of sodium L-pyrrolidone carboxylate, 0.2-0.3% of semen aesculi-bletilla striata composite extract, 1.5-2% of cactus juice, 0.2-0.3% of phytosterol, 0.5-0.8% of wild buckwheat rhizome extract, 0.3-0.4% of behen extract, 1-1.2% of fructo-oligosaccharide, 5-8% of amphoteric surfactant, 2-3% of anionic surfactant, 1-2% of nonionic surfactant, 0.2-0.5% of foam stabilizer and 100% of deionized water, wherein the wild buckwheat rhizome extract and the behen rhizome extract are embedded by hydroxypropyl- β -cyclodextrin, and the semen aesculi-bletilla striata composite extract is coated by a collagen film.
Preferably, the buckeye seed-bletilla striata compound extract is extracted by the following method: drying semen Aesculi and rhizoma Bletillae, mixing, pulverizing, sieving to obtain coarse powder, and mixing the coarse powder with CO2Extracting with supercritical fluid, separating and collecting volatile effective components and liposoluble effective components, and mixing.
Further preferably, CO2The extraction temperature of the supercritical fluid extraction is 40-50 ℃, the extraction pressure is 30-40 MPa, the extraction time is 2-3 hours, and CO is added2The flow rate is 20-25L/h; the separation is carried out at the temperature of 40-50 ℃ and under the pressure of 5-8 MPa.
Preferably, the cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Preferably, the wild buckwheat rhizome extract is obtained by extracting the following steps: drying, crushing and sieving rhizomes of wild buckwheat rhizome to obtain coarse powder, placing the coarse powder in a differential pressure extractor, and cooling the water to 3-4 ℃; vacuumizing: vacuumizing the differential pressure extractor to-50 to-100 MPa within 30-40 seconds, keeping for 2-5 minutes, and spraying deionized water at 15 ℃ for extraction; reducing the vacuum: introducing purified compressed air, and increasing the pressure in the differential pressure extractor to 0MPa within 1-3 minutes; pressurizing: continuously introducing purified compressed air to enable the pressure in the differential pressure extractor to reach 3MPa, and keeping for 2-5 minutes; and (3) reducing pressure: stopping pressurizing, and vacuumizing again to reduce the pressure in the pressure difference extractor to 0 Mpa; repeating the process of vacuumizing to decompressing for a plurality of times, then carrying out solid-liquid separation by centrifugation, filtering the centrifugate, and concentrating the filtrate to obtain a concentrated solution, wherein the relative density of the concentrated solution at 25 ℃ is 1.02; wherein the mass volume ratio of the wild buckwheat rhizome to the deionized water is 1 g: 20 mL.
Preferably, the extract of behenic is extracted by the following method: drying the behen vegetable, then crushing the dried behen vegetable by a high-speed crusher, taking n-hexane as an extraction solvent, wherein the mass volume ratio of the behen vegetable to the n-hexane is 1 g: 20mL of the extract, the microwave power of 750W, 10 minutes of extraction, filtration, and decompression recovery of n-hexane from the extract to obtain a powdery extract of the behenic acid.
Preferably, the mass of the hydroxypropyl- β -cyclodextrin is 5-8 times of the total mass of the wild buckwheat rhizome extract and the behenic root extract.
Preferably, the collagen membrane is formed by using a collagen liquid, wherein the collagen liquid comprises two parts of collagen and deionized water, and the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 4-5 times of the total mass of the buckeye extract and the bletilla striata extract.
Further preferably, the preparation method of the collagen liquid is as follows:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in a 0.05mol/L sodium hydroxide solution 2-3 times of the weight of the raw material for 12-20 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 2 to 3 hours by using a hydrochloric acid solution of 0.05mol/L which is 5 to 8 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
Preferably, the amphoteric surfactant is selected from any one of cocamidopropyl betaine or dodecyl dimethyl amine oxide; the anionic surfactant is selected from any one of polyoxyethylene ether sulfate or isethionate; the nonionic surfactant is selected from any one of polysorbate 20 or coconut oil fatty acid monoethanolamide.
Preferably, the phytosterol is extracted from soybean.
Preferably, the foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70-80 ℃ and dissolving to obtain a phase A;
(2) heating the phytosterol to 80-85 ℃, and carrying out heat preservation and dissolution to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring and dissolving, adding the cactus juice, and performing ultrasonic oscillation for 30-40 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70-80 ℃ until the solution is clear;
(5) slowly cooling to 45-50 ℃, adding the semen aesculi-bletilla striata composite extract coated by the collagen film, the wild buckwheat extract embedded by hydroxypropyl- β -cyclodextrin and the behenic extract, stirring for 20-30 minutes, then adding the phase C, and continuously stirring for 1-2 hours;
(6) cooling to 40 deg.C, and discharging.
Preferably, in the step (5), the collagen film-coated buckeye seed-bletilla striata composite extract is prepared by the following method: adding the semen aesculi-bletilla striata composite extract into the collagen liquid, carrying out ultrasonic oscillation for 30-40 minutes, and then drying for 24 hours at-40 ℃ under the condition of 1.3Pa to obtain the composition.
Preferably, in the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in deionized water 2-3 times the weight of the wild buckwheat rhizome extract and the behenic herb extract, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuously stirring for 20-40 minutes.
The particle size of the coarse powder is 0.3-0.5 mm.
The invention has the beneficial effects that:
1. the shower gel provided by the invention introduces an antibacterial component and a moisturizing component, so that the shower gel is endowed with good antibacterial performance and moisturizing performance, no preservative is required to be additionally added, the antibacterial component comprises a wild buckwheat rhizome extract, a Chinese yam rhizome extract and fructo-oligosaccharide, the wild buckwheat rhizome extract and the Chinese yam rhizome extract are embedded by hydroxypropyl- β -cyclodextrin, stimulation discomfort caused by direct contact of a natural extract and skin is avoided, and the moisturizing component slowly releases to play an antibacterial effect.
2. The extract of rhizome of wild buckwheat rhizome has the inhibiting effect on various bacteria, fungi and the like, the extract of behenic has the strong killing effect on various pathogenic bacteria, and the fructo-oligosaccharide is a natural active substance, effectively inhibits the growth of harmful bacteria, fungi and the like, and has the combined action of the fructo-oligosaccharide, the wild buckwheat rhizome, the fructo-oligosaccharide and the fructo-oligosaccharide to kill pathogenic bacteria and inhibit the breeding of bacteria, fungi and the like again, thereby playing a long-term antibacterial role.
3. The sodium L-pyrrolidone carboxylate is a moisturizing agent with extremely high safety, and hardly causes irritation to the skin, the cactus juice, the buckeye seeds and the bletilla striata are rich in colloidal substances, and can form a colloidal film on the surface of the skin to play a role in moisturizing, and the phytosterol has very high permeability to the skin, and can guide the moisturizing ingredients to permeate into the skin and adhere to the surface of the skin to play a better role in moisturizing.
4. Hydroxypropyl- β -cyclodextrin and collagen components can temporarily form a film on the skin surface to reduce the loss of skin moisture, and play a role in locking moisture and keeping moisture.
5. During preparation, a phase A (various surfactants, a foam stabilizer and part of deionized water), a phase B (phytosterol) and a phase C (L-sodium pyrrolidone carboxylate, fructo-oligosaccharide, cactus juice and residual deionized water) are prepared respectively, then the phase A and the phase B are mixed to uniformly disperse the phytosterol in a system, and finally, a buckeye-bletilla striata composite extract coated by a collagen film, a wild buckwheat extract embedded by hydroxypropyl- β -cyclodextrin, a behenic extract and the phase C are added to contribute to uniform dispersion of all components in the system and ensure uniformity and stability of products.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.5% of L-pyrrolidone sodium carboxylate, 0.2% of Chinese buckeye seed-bletilla striata composite extract, 1.5% of cactus juice, 0.2% of phytosterol, 0.5% of wild buckwheat rhizome extract, 0.3% of Chinese behenic herb extract, 1% of fructo-oligosaccharide, 5% of amphoteric surfactant, 2% of anionic surfactant, 1% of nonionic surfactant, 0.2% of foam stabilizer and the balance of deionized water to 100%, wherein the wild buckwheat rhizome extract and the Chinese behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata composite extract is obtained by mixing a buckeye seed extract and a bletilla striata extract, wherein the buckeye seed extract is purchased from Saiyuan Sen biotechnology limited, and the bletilla striata extract is purchased from Shaanxi Sinuote biotechnology limited.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Wild buckwheat extract was obtained from Bolin biotechnologies, Shanxi, and behena extract was obtained from West Ansenran bioengineering, Inc.
The mass of hydroxypropyl- β -cyclodextrin is 5 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 4 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution 2 times the weight of the raw material for 12 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 2 hours by using a hydrochloric acid solution of 0.05mol/L which is 5 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is polyoxyethylene ether sulfate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 80 ℃, preserving heat and dissolving to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 30 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70 ℃ until the solution is clear;
(5) slowly cooling to 45 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract coated with collagen film, rhizoma Fagopyri Dibotryis extract and radix beheni extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 20 min, adding phase C, and stirring for 1 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating with ultrasonic wave for 30 minutes, and drying at-40 deg.C under 1.3Pa for 24 hours to obtain the final product.
In the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in 2 times of deionized water by weight, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 20 minutes.
Example 2
The moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.8% of L-pyrrolidone sodium carboxylate, 0.3% of Chinese buckeye seed-bletilla striata composite extract, 2% of cactus juice, 0.3% of phytosterol, 0.8% of wild buckwheat rhizome extract, 0.4% of Chinese behenic herb extract, 1.2% of fructo-oligosaccharide, 8% of amphoteric surfactant, 3% of anionic surfactant, 2% of nonionic surfactant, 0.5% of foam stabilizer and 100% of deionized water, wherein the wild buckwheat rhizome extract and the Chinese behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata composite extract is obtained by mixing a buckeye seed extract and a bletilla striata extract, wherein the buckeye seed extract is purchased from Saiyuan Sen biotechnology limited, and the bletilla striata extract is purchased from Shaanxi Sinuote biotechnology limited.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Wild buckwheat extract was obtained from Bolin biotechnologies, Shanxi, and behena extract was obtained from West Ansenran bioengineering, Inc.
The mass of hydroxypropyl- β -cyclodextrin is 8 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 5 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution with the weight 3 times that of the raw material for 20 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 3 hours by using a hydrochloric acid solution of 0.05mol/L which is 8 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is dodecyl dimethyl amine oxide; the anionic surfactant is hydroxyethyl sulfonate; the nonionic surfactant is coconut oil fatty acid monoethanolamide.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 80 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 85 ℃, and performing heat preservation and dissolution to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 40 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 80 ℃ until the solution is clear;
(5) slowly cooling to 50 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract coated with collagen film, rhizoma Fagopyri Dibotryis extract and radix beheni extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 30 min, adding phase C, and stirring for 2 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating for 40 minutes by ultrasonic wave, and drying for 24 hours at-40 ℃ under 1.3Pa to obtain the composition.
In the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in deionized water 3 times the weight of the extract, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 40 minutes.
Example 3
The moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.5% of L-pyrrolidone sodium carboxylate, 0.3% of Chinese buckeye seed-bletilla striata composite extract, 1.5% of cactus juice, 0.3% of phytosterol, 0.5% of wild buckwheat rhizome extract, 0.4% of Chinese behenic herb extract, 1% of fructo-oligosaccharide, 8% of amphoteric surfactant, 2% of anionic surfactant, 2% of nonionic surfactant, 0.2% of foam stabilizer and 100% of deionized water, wherein the wild buckwheat rhizome extract and the Chinese behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata compound extract is extracted by the following method: drying semen Aesculi and rhizoma Bletillae, mixing, and pulverizingSieving to obtain coarse powder, and introducing CO into the coarse powder2Extracting with supercritical fluid, separating and collecting volatile effective components and liposoluble effective components, and mixing. CO 22The supercritical fluid extraction temperature is 50 deg.C, extraction pressure is 30MPa, extraction time is 3 hr, and CO is added2The flow rate is 20L/h; the separation is carried out at 50 ℃ and under 5 MPa.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
The wild buckwheat rhizome extract is obtained by the following method: drying, crushing and sieving the rhizome of the wild buckwheat rhizome to obtain coarse powder, placing the coarse powder in a differential pressure extractor, and cooling the water to 4 ℃; vacuumizing: vacuumizing the differential pressure extractor to-100 MPa within 30 seconds, keeping for 2 minutes, and spraying deionized water at 15 ℃ for extraction; reducing the vacuum: purified compressed air is introduced, and the pressure in the differential pressure extractor is increased to 0MPa within 3 minutes; pressurizing: continuously introducing purified compressed air to make the pressure in the differential pressure extractor reach 3MPa, and keeping for 2 minutes; and (3) reducing pressure: stopping pressurizing, and vacuumizing again to reduce the pressure in the pressure difference extractor to 0 Mpa; repeating the process of vacuumizing to decompressing for a plurality of times, then carrying out solid-liquid separation by centrifugation, filtering the centrifugate, and concentrating the filtrate to obtain a concentrated solution, wherein the relative density of the concentrated solution at 25 ℃ is 1.02; wherein the mass volume ratio of the wild buckwheat rhizome to the deionized water is 1 g: 20 mL.
The extract of the behenic is extracted by the following method: drying the behen vegetable, then crushing the dried behen vegetable by a high-speed crusher, taking n-hexane as an extraction solvent, wherein the mass volume ratio of the behen vegetable to the n-hexane is 1 g: 20mL of the extract, the microwave power of 750W, 10 minutes of extraction, filtration, and decompression recovery of n-hexane from the extract to obtain a powdery extract of the behenic acid.
The mass of hydroxypropyl- β -cyclodextrin is 8 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 4 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution with the weight 3 times that of the raw material for 12 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 2 hours by using a hydrochloric acid solution of 0.05mol/L which is 8 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is hydroxyethyl sulfonate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 80 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 80 ℃, preserving heat and dissolving to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 40 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70 ℃ until the solution is clear;
(5) slowly cooling to 50 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract coated with collagen film, rhizoma Fagopyri Dibotryis extract and radix beheni extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 20 min, adding phase C, and stirring for 2 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating with ultrasonic wave for 30 minutes, and drying at-40 deg.C under 1.3Pa for 24 hours to obtain the final product.
In the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in deionized water 3 times the weight of the extract, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 20 minutes.
Example 4
The moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.8% of L-pyrrolidone sodium carboxylate, 0.2% of Chinese buckeye seed-bletilla striata composite extract, 2% of cactus juice, 0.2% of phytosterol, 0.8% of wild buckwheat rhizome extract, 0.3% of Chinese behenic herb extract, 1.2% of fructo-oligosaccharide, 5% of amphoteric surfactant, 3% of anionic surfactant, 1% of nonionic surfactant, 0.5% of foam stabilizer and 100% of deionized water, wherein the wild buckwheat rhizome extract and the Chinese behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata compound extract is extracted by the following method: drying semen Aesculi and rhizoma Bletillae, mixing, pulverizing, sieving to obtain coarse powder, and mixing the coarse powder with CO2Extracting with supercritical fluid, separating and collecting volatile effective components and liposoluble effective components, and mixing. CO 22The supercritical fluid extraction temperature is 40 deg.C, extraction pressure is 40MPa, extraction time is 2 hr, and CO is added2The flow rate is 25L/h; the separation is carried out at 40 ℃ and under 8 MPa.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
The wild buckwheat rhizome extract is obtained by the following method: drying, crushing and sieving the rhizome of the wild buckwheat rhizome to obtain coarse powder, placing the coarse powder in a differential pressure extractor, and cooling the water to 3 ℃; vacuumizing: vacuumizing the differential pressure extractor to-50 MPa within 40 seconds, keeping for 5 minutes, and spraying deionized water at 15 ℃ for extraction; reducing the vacuum: purified compressed air is introduced, and the pressure in the differential pressure extractor is increased to 0MPa within 1 minute; pressurizing: continuously introducing purified compressed air to make the pressure in the differential pressure extractor reach 3MPa, and keeping for 5 minutes; and (3) reducing pressure: stopping pressurizing, and vacuumizing again to reduce the pressure in the pressure difference extractor to 0 Mpa; repeating the process of vacuumizing to decompressing for a plurality of times, then carrying out solid-liquid separation by centrifugation, filtering the centrifugate, and concentrating the filtrate to obtain a concentrated solution, wherein the relative density of the concentrated solution at 25 ℃ is 1.02; wherein the mass volume ratio of the wild buckwheat rhizome to the deionized water is 1 g: 20 mL.
The extract of the behenic is extracted by the following method: drying the behen vegetable, then crushing the dried behen vegetable by a high-speed crusher, taking n-hexane as an extraction solvent, wherein the mass volume ratio of the behen vegetable to the n-hexane is 1 g: 20mL of the extract, the microwave power of 750W, 10 minutes of extraction, filtration, and decompression recovery of n-hexane from the extract to obtain a powdery extract of the behenic acid.
The mass of hydroxypropyl- β -cyclodextrin is 5 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 5 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution 2 times the weight of the raw material for 20 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 3 hours by using a hydrochloric acid solution of 0.05mol/L which is 5 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is dodecyl dimethyl amine oxide; the anionic surfactant is polyoxyethylene ether sulfate; the nonionic surfactant is coconut oil fatty acid monoethanolamide.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 85 ℃, and performing heat preservation and dissolution to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 30 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 80 ℃ until the solution is clear;
(5) slowly cooling to 45 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract coated with collagen film, rhizoma Fagopyri Dibotryis extract and radix beheni extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 30 min, adding phase C, and stirring for 1 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating for 40 minutes by ultrasonic wave, and drying for 24 hours at-40 ℃ under 1.3Pa to obtain the composition.
In the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in 2 times of deionized water by weight, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 40 minutes.
Example 5
The moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.6% of L-pyrrolidone sodium carboxylate, 0.25% of Chinese buckeye seed-bletilla striata composite extract, 1.8% of cactus juice, 0.25% of phytosterol, 0.7% of wild buckwheat rhizome extract, 0.35% of Chinese behenic herb extract, 1-1.1% of fructo-oligosaccharide, 7% of amphoteric surfactant, 2.5% of anionic surfactant, 1.5% of nonionic surfactant, 0.3% of foam stabilizer and the balance of deionized water to 100%, wherein the wild buckwheat rhizome extract and the Chinese behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata compound extract is extracted by the following method: drying semen Aesculi and rhizoma Bletillae, mixing, pulverizing, sieving to obtain coarse powder, and mixing the coarse powder with CO2Extracting with supercritical fluid, separating and collecting volatile effective components and liposoluble effective components, and mixing. CO 22The extraction temperature of the supercritical fluid extraction is 45 ℃, the extraction pressure is 35MPa, the extraction time is 2.5 hours, and CO is added2The flow rate is 22L/h; the separation temperature is 45 ℃ and the pressure is 7 MPa.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
The wild buckwheat rhizome extract is obtained by the following method: drying, crushing and sieving the rhizome of the wild buckwheat rhizome to obtain coarse powder, placing the coarse powder in a differential pressure extractor, and cooling the water to 4 ℃; vacuumizing: vacuumizing the differential pressure extractor to-80 MPa within 35 seconds, keeping for 3 minutes, and spraying deionized water at 15 ℃ for extraction; reducing the vacuum: purified compressed air is introduced, and the pressure in the differential pressure extractor is increased to 0MPa within 2 minutes; pressurizing: continuously introducing purified compressed air to make the pressure in the differential pressure extractor reach 3MPa, and keeping for 4 minutes; and (3) reducing pressure: stopping pressurizing, and vacuumizing again to reduce the pressure in the pressure difference extractor to 0 Mpa; repeating the process of vacuumizing to decompressing for a plurality of times, then carrying out solid-liquid separation by centrifugation, filtering the centrifugate, and concentrating the filtrate to obtain a concentrated solution, wherein the relative density of the concentrated solution at 25 ℃ is 1.02; wherein the mass volume ratio of the wild buckwheat rhizome to the deionized water is 1 g: 20 mL.
The extract of the behenic is extracted by the following method: drying the behen vegetable, then crushing the dried behen vegetable by a high-speed crusher, taking n-hexane as an extraction solvent, wherein the mass volume ratio of the behen vegetable to the n-hexane is 1 g: 20mL of the extract, the microwave power of 750W, 10 minutes of extraction, filtration, and decompression recovery of n-hexane from the extract to obtain a powdery extract of the behenic acid.
The mass of hydroxypropyl- β -cyclodextrin is 6 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 4 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution with the weight 3 times that of the raw material for 15 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 3 hours by using a hydrochloric acid solution of 0.05mol/L with the weight 6 times that of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is hydroxyethyl sulfonate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 75 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 82 ℃, preserving heat and dissolving to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 35 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 75 ℃ until the solution is clear;
(5) slowly cooling to 48 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract coated with collagen film, rhizoma Fagopyri Dibotryis extract and radix beheni extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 25 min, adding phase C, and stirring for 2 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating for 35 minutes by ultrasonic wave, and drying for 24 hours at-40 deg.C under 1.3Pa to obtain the final product.
In the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in deionized water 3 times the weight of the extract, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 30 minutes.
Comparative example 1
The shower gel is prepared from the following raw materials in percentage by weight:
0.5% of sodium L-pyrrolidone carboxylate, 1.5% of cactus juice, 0.2% of phytosterol, 0.5% of wild buckwheat rhizome extract, 0.3% of behenic herb extract, 1% of fructo-oligosaccharide, 5% of amphoteric surfactant, 2% of anionic surfactant, 1% of nonionic surfactant, 0.2% of foam stabilizer and 100% of deionized water, wherein the wild buckwheat rhizome extract and the behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Wild buckwheat extract was obtained from Bolin biotechnologies, Shanxi, and behena extract was obtained from West Ansenran bioengineering, Inc.
The mass of hydroxypropyl- β -cyclodextrin is 5 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is polyoxyethylene ether sulfate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 80 ℃, preserving heat and dissolving to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 30 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70 ℃ until the solution is clear;
(5) slowly cooling to 45 deg.C, adding rhizoma Fagopyri Dibotryis extract and radix beheni extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 20 min, adding phase C, and stirring for 1 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in 2 times of deionized water by weight, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 20 minutes.
Comparative example 2
The shower gel is prepared from the following raw materials in percentage by weight:
0.5% of L-pyrrolidone sodium carboxylate, 0.2% of Chinese buckeye seed-bletilla striata composite extract, 1.5% of cactus juice, 0.2% of phytosterol, 0.3% of behenic extract, 1% of fructo-oligosaccharide, 5% of amphoteric surfactant, 2% of anionic surfactant, 1% of nonionic surfactant, 0.2% of foam stabilizer and 100% of deionized water, wherein the behenic extract is embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata composite extract is obtained by mixing a buckeye seed extract and a bletilla striata extract, wherein the buckeye seed extract is purchased from Saiyuan Sen biotechnology limited, and the bletilla striata extract is purchased from Shaanxi Sinuote biotechnology limited.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Behenic extract, purchased from west andran ran bioengineering, ltd.
The mass of hydroxypropyl- β -cyclodextrin was 5 times the total mass of the extract of behenic acid.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 4 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution 2 times the weight of the raw material for 12 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 2 hours by using a hydrochloric acid solution of 0.05mol/L which is 5 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is polyoxyethylene ether sulfate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 80 ℃, preserving heat and dissolving to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 30 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70 ℃ until the solution is clear;
(5) slowly cooling to 45 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract coated with collagen film and behenic extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 20 min, adding phase C, and stirring for 1 hr;
(6) cooling to 40 deg.C, and discharging.
In the step (5), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating with ultrasonic wave for 30 minutes, and drying at-40 deg.C under 1.3Pa for 24 hours to obtain the final product.
In the step (5), the behenic extract embedded with hydroxypropyl- β -cyclodextrin is prepared by dissolving hydroxypropyl- β -cyclodextrin in 2 times of deionized water, adding the behenic extract while stirring, and continuing to stir for 20 minutes.
Comparative example 3
The shower gel is prepared from the following raw materials in percentage by weight:
0.5% of L-pyrrolidone sodium carboxylate, 0.2% of Chinese buckeye seed-bletilla striata composite extract, 1.5% of cactus juice, 0.2% of phytosterol, 0.5% of wild buckwheat rhizome extract, 0.3% of Chinese behenic extract, 1% of fructo-oligosaccharide, 5% of amphoteric surfactant, 2% of anionic surfactant, 1% of nonionic surfactant, 0.2% of foam stabilizer and the balance of deionized water to 100%.
The buckeye seed-bletilla striata composite extract is obtained by mixing a buckeye seed extract and a bletilla striata extract, wherein the buckeye seed extract is purchased from Saiyuan Sen biotechnology limited, and the bletilla striata extract is purchased from Shaanxi Sinuote biotechnology limited.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Wild buckwheat extract was obtained from Bolin biotechnologies, Shanxi, and behena extract was obtained from West Ansenran bioengineering, Inc.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is polyoxyethylene ether sulfate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70 ℃ and dissolving to obtain phase A;
(2) heating phytosterol to 80 ℃, preserving heat and dissolving to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring to dissolve, adding the cactus juice, and performing ultrasonic oscillation for 30 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70 ℃ until the solution is clear;
(5) slowly cooling to 45 deg.C, adding semen Aesculi-rhizoma Bletillae composite extract, rhizoma Fagopyri Dibotryis extract and radix behenate extract coated with collagen membrane, stirring for 20 min, adding phase C, and stirring for 1 hr;
(6) cooling to 40 deg.C, and discharging.
Comparative example 4
The moisturizing antibacterial shower gel is prepared from the following raw materials in percentage by weight:
0.5% of L-pyrrolidone sodium carboxylate, 0.2% of Chinese buckeye seed-bletilla striata composite extract, 1.5% of cactus juice, 0.2% of phytosterol, 0.5% of wild buckwheat rhizome extract, 0.3% of Chinese behenic herb extract, 1% of fructo-oligosaccharide, 5% of amphoteric surfactant, 2% of anionic surfactant, 1% of nonionic surfactant, 0.2% of foam stabilizer and the balance of deionized water to 100%, wherein the wild buckwheat rhizome extract and the Chinese behenic herb extract are embedded by hydroxypropyl- β -cyclodextrin, and the Chinese buckeye seed-bletilla striata composite extract is coated by a collagen film.
The buckeye seed-bletilla striata composite extract is obtained by mixing a buckeye seed extract and a bletilla striata extract, wherein the buckeye seed extract is purchased from Saiyuan Sen biotechnology limited, and the bletilla striata extract is purchased from Shaanxi Sinuote biotechnology limited.
The cactus juice is a mucilage obtained by squeezing succulent stems of cactus.
Wild buckwheat extract was obtained from Bolin biotechnologies, Shanxi, and behena extract was obtained from West Ansenran bioengineering, Inc.
The mass of hydroxypropyl- β -cyclodextrin is 5 times of the total mass of rhizoma Fagopyri Dibotryis extract and radix behenate extract.
The collagen film is formed by collagen liquid, the collagen liquid comprises two parts of collagen and deionized water, the mass volume ratio of the two parts is 1 g: 30mL, the mass of the collagen liquid is 4 times of the total mass of the buckeye extract and the bletilla striata extract. The preparation method of the collagen liquid comprises the following steps:
(A) extracting crude collagen: taking one of fishbone, fish skin, fish scales or fish tendon as a raw material, soaking the raw material in 0.05mol/L sodium hydroxide solution 2 times the weight of the raw material for 12 hours, and rinsing the raw material to be neutral by using clear water; then stirring and soaking the raw materials for 2 hours by using a hydrochloric acid solution of 0.05mol/L which is 5 times of the weight of the raw materials, rinsing the raw materials to be neutral by using clear water, and crushing the raw materials to prepare crude collagen;
(B) preparation of collagen liquid: adding deionized water into the crude collagen, leaching at 80 ℃, and filtering insoluble substances to obtain the collagen, wherein the mass volume ratio of the crude collagen to the deionized water is 1 g: 30 mL.
The amphoteric surfactant is cocamidopropyl betaine; the anionic surfactant is polyoxyethylene ether sulfate; the nonionic surfactant is polysorbate 20.
The foam stabilizer is polyethylene glycol-14M.
The preparation method of the moisturizing antibacterial shower gel comprises the following steps:
(1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and deionized water in the formula ratio to 70 ℃, and dissolving to obtain a phase A;
(2) heating phytosterol to 80 ℃, preserving heat and dissolving to obtain a phase B;
(3) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70 ℃ until the solution is clear;
(4) slowly cooling to 45 deg.C, adding L-pyrrolidone carboxylic acid sodium, fructo-oligosaccharide, semen Aesculi-rhizoma Bletillae composite extract coated with cactus juice collagen film, rhizoma Fagopyri Dibotryis extract and radix behenae extract embedded with hydroxypropyl- β -cyclodextrin, stirring for 20 min, adding phase C, and stirring for 1 hr;
(5) cooling to 40 deg.C, and discharging.
In the step (4), the buckeye seed-bletilla striata composite extract coated by the collagen film is prepared by the following method: adding semen Aesculi-bletilla striata composite extract into collagen liquid, oscillating with ultrasonic wave for 30 minutes, and drying at-40 deg.C under 1.3Pa for 24 hours to obtain the final product.
In the step (4), the wild buckwheat rhizome extract and the behenic herb extract embedded with the hydroxypropyl- β -cyclodextrin are prepared by dissolving the hydroxypropyl- β -cyclodextrin in 2 times of deionized water by weight, adding the wild buckwheat rhizome extract and the behenic herb extract while stirring, and continuing to stir for 20 minutes.
Test examples
1. Stability of
The shower gel of the examples 1-5 and the shower gel of the comparative examples 1-4 are respectively placed at-3 ℃ and 30 ℃ for 48 hours, and the shower gel of the examples 1-5 and the shower gel of the comparative examples 1-3 has no changes such as layering, precipitation, crystallization or color change, and the like, so that the shower gel has good stability; the shower gel of comparative example 4 showed precipitation at both temperature conditions, indicating poor stability.
2. Antibacterial effect
Respectively inoculating staphylococcus aureus and candida albicans on the plane of the agar plate nutrient solution, uniformly and densely distributing the staphylococcus aureus and the candida albicans during inoculation, taking a sterile circular filter paper piece by tweezers, respectively spraying the shower gel of the examples 1-5 or the comparative examples 2-4 until the sterile circular filter paper piece is completely wetted, and sticking the sterile circular filter paper piece on the plane of the agar plate nutrient solution inoculated with bacteria, fungi and the like. The agar plates were placed in an incubator at 37 ℃ and incubated for 24 hours. The diameter of the antibacterial ring was measured. The average was taken 3 times. The results are shown in Table 1.
TABLE 1 comparison of the bacteriostatic Ring diameters for different treatment solutions
As can be seen from Table 1, the shower gel of examples 1 to 5 has a strong inhibitory effect on Staphylococcus aureus and Candida albicans. Comparative example 2 omitting wild buckwheat rhizome extract, the antibacterial property was significantly deteriorated; comparative example 3 omits a coating component, and influences the antibacterial effect exertion of the antibacterial component; in comparative example 4, the C phase component was directly added without preparing the C phase in advance, and the uniformity of the body wash became poor to affect the antibacterial effect.
3. Moisturizing effect
80 skin healthy subjects without a skin disease allergy history are selected, the subjects are aged 25-28 years and half of men and women are randomly divided into 8 groups, the number of men and women in each group is the same, a test area is defined, the shower gel of examples 1-5 or comparative example 1, comparative example 3 and comparative example 4 is used respectively, the skin moisture content (average value) before washing and after 2 hours of washing is tested respectively by a moisture tester, and the moisture content increase percentage is calculated, and the results are shown in table 2.
The test area is 5cm inside the forearm of the right hand of the subject2The position of (a).
TABLE 2 comparison of moisturizing Effect
As can be seen from Table 1, the shower gel of examples 1 to 5 had excellent moisturizing effect. In the comparative example 1, the buckeye seed-bletilla striata composite extract is omitted, and the antibacterial performance is obviously poor; comparative example 3 omits a coating component, and influences the antibacterial effect of the moisturizing component; in comparative example 4, the C phase component was directly added without preparing the C phase in advance, and the uniformity of the body wash was deteriorated to influence the moisturizing effect.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (4)
1. The moisturizing antibacterial shower gel and the preparation method thereof are characterized by being prepared from the following raw materials in percentage by weight:
0.5-0.8% of sodium L-pyrrolidone carboxylate, 0.2-0.3% of semen aesculi-bletilla striata composite extract, 1.5-2% of cactus juice, 0.2-0.3% of phytosterol, 0.5-0.8% of wild buckwheat extract, 0.3-0.4% of behenic extract, 1-1.2% of fructo-oligosaccharide, 5-8% of amphoteric surfactant, 2-3% of anionic surfactant, 1-2% of nonionic surfactant, 0.2-0.5% of foam stabilizer and the balance of deionized water to 100%, wherein the wild buckwheat extract and the behenic extract are embedded by hydroxypropyl- β -cyclodextrin, the semen aesculi-bletilla striata composite extract is coated by a collagen film, the semen aesculi-bletilla striata composite extract is extracted by the following method that semen aesculi and bletilla striata are dried, mixed, crushed and sieved to obtain coarse powder, and the coarse powder is prepared by adopting CO2Extracting with supercritical fluid, separating and collecting volatile effective components and liposoluble effective components, and mixing the volatile effective components and liposoluble effective components; the rhizoma Fagopyri DibotryisThe extract is obtained by the following method: drying, crushing and sieving rhizomes of wild buckwheat rhizome to obtain coarse powder, placing the coarse powder in a differential pressure extractor, and cooling the water to 3-4 ℃; vacuumizing: vacuumizing the differential pressure extractor to-50 to-100 MPa within 30-40 seconds, keeping for 2-5 minutes, and spraying deionized water at 15 ℃ for extraction; reducing the vacuum: introducing purified compressed air, and increasing the pressure in the differential pressure extractor to 0MPa within 1-3 minutes; pressurizing: continuously introducing purified compressed air to enable the pressure in the differential pressure extractor to reach 3MPa, and keeping for 2-5 minutes; and (3) reducing pressure: stopping pressurizing, and vacuumizing again to reduce the pressure in the pressure difference extractor to 0 Mpa; repeating the process of vacuumizing to decompressing for a plurality of times, then carrying out solid-liquid separation by centrifugation, filtering the centrifugate, and concentrating the filtrate to obtain a concentrated solution, wherein the relative density of the concentrated solution at 25 ℃ is 1.02; wherein the mass volume ratio of the wild buckwheat rhizome to the deionized water is 1 g: 20 mL; the extract of the behenic is extracted by the following method: drying the behen vegetable, then crushing the dried behen vegetable by a high-speed crusher, taking n-hexane as an extraction solvent, wherein the mass volume ratio of the behen vegetable to the n-hexane is 1 g: 20mL of the extract, the microwave power of 750W, 10 minutes of extraction, filtration and decompression of the extract to recover n-hexane, thus obtaining a powdery extract of the behenic vegetable; the preparation method of the moisturizing antibacterial shower gel comprises the following steps:
1) heating the amphoteric surfactant, the nonionic surfactant, the anionic surfactant, the foam stabilizer and the 2/3 deionized water to 70-80 ℃ and dissolving to obtain a phase A;
(2) heating the phytosterol to 80-85 ℃, and carrying out heat preservation and dissolution to obtain a phase B;
(3) adding the sodium L-pyrrolidone carboxylate and fructo-oligosaccharide in the formula amount into the deionized water in the rest formula amount, stirring and dissolving, adding the cactus juice, and performing ultrasonic oscillation for 30-40 minutes to obtain a phase C;
(4) uniformly mixing the phase B and the phase A, and carrying out heat preservation treatment at 70-80 ℃ until the solution is clear;
(5) slowly cooling to 45-50 ℃, adding the semen aesculi-bletilla striata composite extract coated by the collagen film, the wild buckwheat extract embedded by hydroxypropyl- β -cyclodextrin and the behenic extract, stirring for 20-30 minutes, then adding the phase C, and continuously stirring for 1-2 hours;
(6) cooling to 40 deg.C, and discharging.
2. The method according to claim 1, wherein the hydroxypropyl- β -cyclodextrin is 5 to 8 times the total mass of the Fagopyrum cymosum extract and the behenic extract.
3. The preparation method according to claim 1, wherein the collagen film is formed by using a collagen liquid, wherein the collagen liquid comprises two parts of collagen and deionized water, and the mass-to-volume ratio of the collagen to the deionized water is 1 g: 30mL, the mass of the collagen liquid is 4-5 times of the total mass of the buckeye extract and the bletilla striata extract.
4. The method of claim 1, wherein the amphoteric surfactant is selected from any one of cocamidopropyl betaine or dodecyl dimethyl amine oxide; the anionic surfactant is selected from any one of polyoxyethylene ether sulfate or isethionate; the nonionic surfactant is selected from any one of polysorbate 20 or coconut oil fatty acid monoethanolamide.
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| CN112220735A (en) * | 2020-11-19 | 2021-01-15 | 聂绪明 | EM (effective microorganism) fungus shower gel and preparation method thereof |
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| WO2003061554A2 (en) * | 2002-01-26 | 2003-07-31 | Micro Science Tech Co., Ltd | Composition containing moutan root bark extract as active ingredient |
| US6824763B2 (en) * | 2002-05-30 | 2004-11-30 | Kimberly-Clark Worldwide, Inc. | Anti-fungal powder having enhanced excipient properties |
| FR2852237B1 (en) * | 2003-03-11 | 2006-07-14 | Oreal | COSMETIC COMPOSITIONS CONTAINING METHACRYLIC ACID COPOLYMER, CYCLODEXTRIN AND SURFACTANT AND USES THEREOF |
| DE10341654A1 (en) * | 2003-09-08 | 2005-04-07 | Beiersdorf Ag | Agent for use on the skin and / or the hair containing 4-substituted cyclohexene compounds |
| DE10341663A1 (en) * | 2003-09-08 | 2005-04-07 | Beiersdorf Ag | Skin and / or hair agent containing 4-substituted cyclohexene compounds |
| CN103142454A (en) * | 2012-07-14 | 2013-06-12 | 邵素英 | Shower gel |
| CN103315932B (en) * | 2013-06-05 | 2014-11-12 | 片仔癀（上海）生物科技研发有限公司 | Itching-relieving body wash and preparation method thereof |
| CN106074471B (en) * | 2016-07-14 | 2018-12-07 | 新疆大学 | A kind of preparation method of new bacteriostatic agent hexahydro β-acid cyclodextrin inclusion compound |
| CN105997745A (en) * | 2016-07-15 | 2016-10-12 | 张进 | Liquid makeup with moisture retention and sun protection functions |
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