CN114366698B - Anti-aging composition, preparation method thereof and application thereof in cosmetics - Google Patents
Anti-aging composition, preparation method thereof and application thereof in cosmetics Download PDFInfo
- Publication number
- CN114366698B CN114366698B CN202111397926.5A CN202111397926A CN114366698B CN 114366698 B CN114366698 B CN 114366698B CN 202111397926 A CN202111397926 A CN 202111397926A CN 114366698 B CN114366698 B CN 114366698B
- Authority
- CN
- China
- Prior art keywords
- extract
- aging composition
- aging
- skin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 92
- 239000000203 mixture Substances 0.000 title claims abstract description 90
- 239000002537 cosmetic Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000000284 extract Substances 0.000 claims abstract description 92
- 239000000463 material Substances 0.000 claims abstract description 62
- 150000004676 glycans Chemical class 0.000 claims abstract description 25
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 25
- 239000005017 polysaccharide Substances 0.000 claims abstract description 25
- 108090000637 alpha-Amylases Proteins 0.000 claims abstract description 22
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims abstract description 21
- 244000304217 Brassica oleracea var. gongylodes Species 0.000 claims abstract description 20
- 241000219823 Medicago Species 0.000 claims abstract description 20
- 229940118127 fucus vesiculosus extract Drugs 0.000 claims abstract description 13
- 229940075887 saccharomyces cerevisiae extract Drugs 0.000 claims abstract description 12
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 10
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 239000011162 core material Substances 0.000 claims description 29
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 15
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 15
- 230000001815 facial effect Effects 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 235000012000 cholesterol Nutrition 0.000 claims description 13
- 241000227647 Fucus vesiculosus Species 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 12
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- 229960005323 phenoxyethanol Drugs 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 239000000686 essence Substances 0.000 claims description 8
- 241000195493 Cryptophyta Species 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 229940041514 candida albicans extract Drugs 0.000 claims description 4
- 239000012138 yeast extract Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 239000004909 Moisturizer Substances 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- -1 facial mask Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 230000001333 moisturizer Effects 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 241000195480 Fucus Species 0.000 claims 1
- 235000019668 heartiness Nutrition 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 11
- 230000035699 permeability Effects 0.000 abstract description 9
- 230000036542 oxidative stress Effects 0.000 abstract description 6
- 230000009759 skin aging Effects 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 239000002502 liposome Substances 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 38
- 238000012360 testing method Methods 0.000 description 33
- 230000008859 change Effects 0.000 description 23
- 230000000694 effects Effects 0.000 description 22
- 230000037394 skin elasticity Effects 0.000 description 18
- 230000037303 wrinkles Effects 0.000 description 14
- 238000012512 characterization method Methods 0.000 description 13
- 229920001218 Pullulan Polymers 0.000 description 8
- 239000004373 Pullulan Substances 0.000 description 8
- 235000019423 pullulan Nutrition 0.000 description 8
- 230000008451 emotion Effects 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 240000004658 Medicago sativa Species 0.000 description 4
- 206010040914 Skin reaction Diseases 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000035483 skin reaction Effects 0.000 description 4
- 231100000430 skin reaction Toxicity 0.000 description 4
- 241000223678 Aureobasidium pullulans Species 0.000 description 3
- 208000032544 Cicatrix Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000168525 Haematococcus Species 0.000 description 3
- 235000010624 Medicago sativa Nutrition 0.000 description 3
- 241000235545 Rhizopus niveus Species 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 231100000241 scar Toxicity 0.000 description 3
- 230000037387 scars Effects 0.000 description 3
- 230000037380 skin damage Effects 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000223651 Aureobasidium Species 0.000 description 2
- 102000012422 Collagen Type I Human genes 0.000 description 2
- 108010022452 Collagen Type I Proteins 0.000 description 2
- 229920000926 Galactomannan Polymers 0.000 description 2
- 240000003394 Malpighia glabra Species 0.000 description 2
- 235000014837 Malpighia glabra Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000002296 dynamic light scattering Methods 0.000 description 2
- 230000002996 emotional effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- CRDAMVZIKSXKFV-YFVJMOTDSA-N (2-trans,6-trans)-farnesol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO CRDAMVZIKSXKFV-YFVJMOTDSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 230000033616 DNA repair Effects 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 241000235527 Rhizopus Species 0.000 description 1
- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 206010050637 Skin tightness Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 238000013473 artificial intelligence Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003012 bilayer membrane Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000010523 cascade reaction Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000008921 facial expression Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000008889 homeostatic pathway Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000004492 retinoid derivatives Chemical class 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses an anti-aging composition, a preparation method thereof and application thereof in cosmetics. The anti-aging composition comprises the following functional raw materials in percentage by mass: 10-40% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 10-40% of kohlrabi extract/pullulanase polysaccharide, 10-40% of alfalfa extract and 0.1-5% of vesicle material. The anti-aging composition is prepared by a non-ionic surfactant, and the vesicle material wraps other active ingredients, so that the anti-aging composition has the characteristics of easy preparation and better percutaneous permeability compared with the traditional liposome material; through the specific proportion collocation, three functional components penetrate through skin to the maximum extent, and the three functional components have synergistic effect, so that the skin is protected, the skin aging and the oxidative stress are resisted, and the skin is healthier.
Description
Technical Field
The invention relates to a cosmetic composition, a preparation method thereof and application thereof in cosmetics, belongs to the technical field of daily chemicals, and particularly relates to an anti-aging composition, a preparation method thereof and application thereof in cosmetics.
Background
Cosmetic products have long been used, and as the living standard of substances of people is continuously improved, the skin care requirements of people are higher and higher, and especially for anti-aging products, the use population is wider and wider. The prior trend of the people over 30 years old to lower ages is that the anti-aging consciousness of people is mature, the basic anti-aging mechanisms of anti-saccharification, anti-photoaging and anti-free radical … … are also the basic anti-aging mechanisms, and consumers can be convinced that the consumers are in charge, so that the anti-aging cosmetics are receiving more and more attention.
However, short plates with poor transdermal absorption effect are commonly existed in the existing cosmetics, and the short plates are particularly obvious in-vitro efficacy, but slow or no obvious effect exists in human efficacy. Meanwhile, some active ingredients with good anti-aging effect have application limitations such as large irritation or poor stability.
Therefore, an anti-aging product with remarkable effect and mild and safe performance is particularly necessary.
Disclosure of Invention
The invention aims to provide a formula of an anti-aging composition and a preparation method thereof, wherein a vesicle material prepared by a nonionic surfactant wraps other active ingredients, and the anti-aging composition has the characteristics of easy preparation and better percutaneous permeability compared with the traditional liposome material; through the specific proportion collocation, three functional components penetrate through skin to the maximum extent, and the three functional components have synergistic effect, so that the skin is protected, the skin aging and the oxidative stress are resisted, and the skin is healthier.
The invention also aims to provide the application of the anti-aging composition in cosmetics, and three functional components penetrate transdermally to the maximum extent, act synergistically, protect skin, resist skin aging and oxidative stress and make skin healthier.
The technical scheme of the invention is as follows:
an anti-aging composition comprises the following main functional components in percentage by mass:
10-40% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 10-40% of kohlrabi extract/pullulanase polysaccharide, 10-40% of alfalfa extract and 0.1-5% of vesicle material.
Further, the anti-aging composition comprises the following main functional components in percentage by mass:
10-35% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 10-35% of kohlrabi extract/pullulanase polysaccharide, 10-35% of alfalfa extract and 0.5-5% of vesicle material.
Further, the anti-aging composition comprises the following main functional components in percentage by mass:
10-30% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 10-30% of kohlrabi extract/pullulanase polysaccharide, 10-30% of alfalfa extract and 0.5-3% of vesicle material.
Further, the anti-aging composition comprises the following main functional components in percentage by mass:
15-25% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 15-25% of kohlrabi extract/pullulanase polysaccharide, 15-25% of alfalfa extract and 1-3% of vesicle material.
Furthermore, the vesicle material is a composite material formed by nonionic surfactant, and the vesicle can be easily formed by only diluting with water and stirring, so that the preparation is easy, and the formed vesicle has the advantages of excellent percutaneous permeability and high stability along with the time.
Specifically, the preparation process of the anti-aging composition comprises the following steps:
respectively weighing the extract of the sea stripe algae, the extract of the Fucus vesiculosus, the extract of the beer yeast, the extract of the kohlrabi, the pullulanase polysaccharide, the extract of the alfalfa and the vesicle material according to the mass percentage.
Dissolving the extract of sea stripe, fucus vesiculosus, saccharomyces cerevisiae, rhizopus prinus, aucklandia lappa and alfalfa extract in deionized water containing 0.7% phenoxyethanol to obtain core material solution.
The vesicle material is mixed with 0.1-5% cholesterol to obtain wall material solution.
Placing the core material solution under a homogenizer at a rotating speed of 1500-3000 rpm, slowly pouring the wall material solution into the core material solution after the rotating speed is stable, and continuously stirring for 30-60 min to obtain the anti-aging composition with a particle size range of 0.05-20 mu m.
The anti-aging composition of the invention comprises the following functional components: the extract of sea-tangle algae/Fucus vesiculosus/Saccharomyces cerevisiae is composed of two aqueous extracts of brown algae (sea-tangle algae, fucus vesiculosus) and selenium-rich Saccharomyces cerevisiae extract, and has excellent antioxidant property, and synergistic effect.
The extract of the kohlrabi/pullulanase polysaccharide can be well attached to skin micro-areas due to the three-dimensional and high molecular weight configuration, and the effects of smoothness and compactness improvement can be immediately seen on the skin surface.
The alfalfa extract has metabolic stimulation to the epidermis and dermis of the skin, exhibits retinoid-like wrinkle-removing activity, and does not cause any side effects.
The vesicle material is prepared from nonionic surfactant, and can improve the percutaneous permeability of active ingredients. Unlike conventional liposome materials, vesicles are easier to prepare, have better percutaneous permeability, and a small amount of cholesterol is added to fill in molecular pores formed by active agent monomers, so that the vesicle bilayer membrane is endowed with certain rigidity, has higher stability over time, and promotes full play of functional components. Through the specific proportion collocation, three functional components penetrate through skin to the maximum extent, and the three functional components have synergistic effect, so that the skin is protected, the skin aging and the oxidative stress are resisted, and the skin is healthier.
The use of an anti-aging composition in cosmetics. The anti-aging composition accounts for 1-20% of the total amount of the cosmetic formulation, preferably ranges from 1-10%, and most preferably ranges from 2-5%. The cosmetic also comprises conventional auxiliary materials accounting for 80-99% of the total amount of the formula of the cosmetic, and can be matched with a plurality of viscosity regulators, emollients, moisturizers, chelating agents, skin-feel conditioning agents, emulsifiers, preservatives, essence and the like according to different skin-feel requirements, so as to prepare the cosmetic in the cosmetic water, mask, gel, essence, emulsion and cream to meet ideal formulation, skin-feel and efficacy requirements.
The invention also provides a novel characterization method of the application of the anti-aging composition in cosmetics, wherein the artificial intelligent AI is used for measuring the influence on emotion after the cosmetics using the composition for the first time, the category of neurology is related, and the positive influence of the anti-aging composition on the skin and the state of a user is further verified.
By means of the technical scheme, the invention has the following advantages and beneficial technical effects:
1) The anti-aging composition overcomes the problems of poor transdermal absorption, slow effect taking or no obvious effect commonly existing in anti-aging products in the market, and the anti-aging composition is a vesicle material composed of nonionic surfactants, improves the transdermal permeability of active ingredients, and takes effect more remarkably and faster.
2) The anti-aging composition consists of the extract of the sea stripe algae, the extract of the Fucus vesiculosus, the extract of the beer yeast, the extract of the kohlrabi, the pullulanase polysaccharide and the alfalfa extract, has excellent anti-oxidation, anti-free radical and anti-aging effects, can be compared with the effects of the traditional efficacy substances of vitamin A and vitamin C, but has no biological irritation, is milder and safer, has better product stability, has no risk of color change and instability, and is easier to apply in skin care products.
3) The anti-aging composition obtained by the specific proportion and combination protects the skin from external environmental stress sources by resisting oxidative stress and heavy metal induced stress reaction. In addition, the preparation method can promote fibroblast proliferation, improve cell activity, promote collagen I and hyaluronic acid synthesis, further relieve molecular network pressure, and consolidate matrix structure. Finally, the facial skin state is comprehensively improved, and the facial contour is more compact and shaped.
4) The application of the anti-aging composition in cosmetics uses artificial intelligence AI technology for the first time, tests the influence of products on emotion, and relates to the category of neurology. The results demonstrate that the use of the product with the added anti-aging composition affects the subconscious emotional well-being of the person, further demonstrating the effectiveness of the anti-aging product.
Drawings
FIG. 1 shows the mean vesicle size rate of change of example 1;
FIG. 2 shows the rate of change of skin wrinkle area rate using the efficacy group of example 4 and the control group;
FIG. 3 shows a partial subject VISIA facial image acquisition using the efficacy set of example 4;
FIG. 4 shows the rate of change of the skin elasticity R0 values using the efficacy and control groups of example 4;
FIG. 5 shows the rate of change of the skin elasticity R2 values using the efficacy and control groups of example 4;
fig. 6 shows a facial emotion collection graph of a portion of subjects using the power and control groups of example 4.
Detailed Description
The invention discloses an anti-aging composition and a preparation method thereof. The anti-aging composition comprises the following main functional components:
10-40% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 10-40% of kohlrabi extract/pullulanase polysaccharide, 10-40% of alfalfa extract and 0.1-5% of vesicle material.
(1) Extract of sea stripe/Fucus vesiculosus/Saccharomyces cerevisiae
The raw material components of the composition are as follows: the extract of the sea stripe, the extract of the Fucus vesiculosus and the extract of the saccharomyces cerevisiae can activate an anti-stress gene regulation network, promote a steady-state channel (homeostatic pathways), and help to strengthen the detoxification function of cells and protect the cells from the cascade reaction of harmful environmental influences. Can maximize the adaptability of cells and make the skin better resist invasive damage. The raw material components are shown in China patent application, namely a facial mask composition containing marine source skin DNA repair cell anti-aging compound and a preparation method thereof (application number CN 202110312378.5).
In an embodiment of the invention, the extract of seastrip is an extract of seastrip: fucus vesiculosus extract: the mass ratio of the beer yeast extract to the beer yeast extract is 0.5-1.5:2.0-5.0:1.5-4.0.
(2) Aureobasidium vivax extract/pullulanase polysaccharide
The English name is MALPIGHIA EMARGINATA (ACEROLA) FRUIT EXTRACT, the EXTRACT of the fructus polygoni cuspidati mainly plays a role of an antioxidant in cosmetics and skin care products, the risk factor is 1, the use can be ensured, the pregnant women are generally not affected, and the EXTRACT of the fructus polygoni cuspidati does not have acne-causing property.
The extract of the kohlrabi has good promotion of the activity of the epidermal cells, has the effect of activating the skin, and can be used in anti-aging cosmetics by combining with the oxidation resistance of the kohlrabi extract.
Pullulanase polysaccharide, english name PULLULAN, alias: pullulan sugar pullulan (pullulan) Aureobasidium polysaccharide, pullulan pullulan, pullulan and pullulan. The pullulanase polysaccharide has the main function of a film forming agent in cosmetics and skin care products.
In the embodiment of the invention, the mass ratio of the extract of the kohlrabi and the pullulanase polysaccharide is 1.5-5.0:2.0-4.0.
(3) Alfalfa extract
The alfalfa extract is rich in galactomannans and can enhance the cellular activities disturbed by the aging process. By regulating keratinocyte differentiation, epidermal renewal can be promoted. The function of protecting and repairing dermis is achieved by stimulating the synthesis of collagen I and weakening the activity of metalloproteinase which causes damage to elastic fibers.
(4) Vesicle material
The vesicle material is a composite material formed by nonionic surfactant, and the vesicle can be easily formed by only diluting with water and stirring, so that the vesicle material has the advantages of easy preparation, excellent percutaneous permeability of the formed vesicle and high stability along with the time.
The present invention used in the examples was a commercially available product Nikkosome PV, available from NIPPON SURFAC-TANT corporation, japan, which is a vesicle material with excellent transdermal permeability. It is a transparent/translucent liquid with a weak characteristic smell.
The components of the composition comprise the following components in the range: 65-80% of glycerin (CAS No. 56-81-5); 0-15% of polyglycerol-10 diisostearate (CAS No. 102033-55-6); 0-10% polyglycerol-10 laurate (CAS No. 34406-66-1); 10-25% of water.
In conclusion, the selected efficacy substance of the invention, namely the stretched sea stripe algae extract/the Fucus vesiculosus extract/the beer yeast extract, has excellent antioxidation characteristic; the extract of the kohlrabi/pullulanase polysaccharide has three-dimensional and high molecular weight configuration, and can remarkably smooth and tighten the skin; the alfalfa extract is rich in galactomannans and exhibits retinoid wrinkle-removing activity without causing any side effects.
The invention is illustrated by the following examples which are given for further illustration of the invention and are not intended to limit the scope of the invention. Some insubstantial modifications and adaptations of the invention by others are within the scope of the invention. The following percentages (%) are mass percentages unless otherwise indicated. The raw material components used in the embodiment of the invention are all commercial products.
Example 1
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
core material components: 24% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 24% of kohlrabi extract/pullulanase polysaccharide, 24% of alfalfa extract and 24.7% of deionized water containing 0.7% of phenoxyethanol.
The manufacturing process comprises the following steps: accurately weighing the components of the core material according to the proportion: extract of Haematococcus elongatus/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, extract of Rhizopus niveus/polysaccharide of Aureobasidium pullulans, and extract of Medicago sativa.
And dissolving the core material component in deionized water containing 0.7% phenoxyethanol to obtain a core material solution. Accurately weighing the wall material components according to the proportion: the vesicle material and cholesterol are mixed to obtain a wall material solution.
Placing the core material solution under a homogenizer at 2000rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain the anti-aging composition with the particle size range of (0.5+/-0.1) mu m.
The preparation method of the embodiment is simple, and is suitable for large-scale popularization, and the prepared anti-aging composition has the characteristics of good anti-aging effect, safety, mildness, slow release and the like.
Example 2
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
core material components: 15% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 22% of kohlrabi extract/pullulanase polysaccharide, 18% of alfalfa extract and 41.7% of deionized water containing 0.7% of phenoxyethanol.
The manufacturing process comprises the following steps: accurately weighing the components of the core material according to the proportion: extract of Haematococcus elongatus/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, extract of Rhizopus niveus/polysaccharide of Aureobasidium pullulans, and extract of Medicago sativa.
And dissolving the core material component in deionized water containing 0.7% phenoxyethanol to obtain a core material solution. Accurately weighing the wall material components according to the proportion: the vesicle material and cholesterol are mixed to obtain a wall material solution.
Placing the core material solution under a homogenizer at 2500rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain the anti-aging composition with the particle size range of (0.5+/-0.1) mu m.
The preparation method of the embodiment is simple, and is suitable for large-scale popularization, and the prepared anti-aging composition has the characteristics of good anti-aging effect, safety, mildness, slow release and the like.
Example 3
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
core material components: 15% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 15% of kohlrabi extract/pullulanase polysaccharide, 15% of alfalfa extract and 51.7% of deionized water containing 0.7% of phenoxyethanol.
The manufacturing process comprises the following steps: accurately weighing the components of the core material according to the proportion: extract of Haematococcus elongatus/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, extract of Rhizopus niveus/polysaccharide of Aureobasidium pullulans, and extract of Medicago sativa.
And dissolving the core material component in deionized water containing 0.7% phenoxyethanol to obtain a core material solution. Accurately weighing the wall material components according to the proportion: the vesicle material and cholesterol are mixed to obtain a wall material solution.
Placing the core material solution under a homogenizer at 2500rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain the anti-aging composition with the particle size range of (0.5+/-0.1) mu m.
The preparation method of the embodiment is simple, and is suitable for large-scale popularization, and the prepared anti-aging composition has the characteristics of good anti-aging effect, safety, mildness, slow release and the like.
Blank examples
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
core material components: 96.7% of deionized water containing 0.7% of phenoxyethanol.
The manufacturing process comprises the following steps: and accurately weighing deionized water containing 0.7% of phenoxyethanol as the core material component according to the proportion to obtain a core material solution. Accurately weighing the wall material components according to the proportion: the vesicle material and cholesterol are mixed to obtain a wall material solution.
Placing the core material solution under a homogenizer at 2500rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain a blank control example, wherein the particle size range is (0.5+/-0.1) mu m.
Examples 4.1 to 4.3
A cosmetic lotion containing antiaging composition comprises the following raw materials in proportion shown in table 1.
Table 1A raw material composition ratio (unit: mass%) of a toning lotion containing an anti-aging composition
The preparation process flow of the astringent containing the anti-aging composition of examples 4.1-4.3 of the present invention is as follows:
1) Sequentially adding the raw materials of phase A into a main tank, stirring, mixing and dissolving uniformly;
2) Sequentially adding the phase B and the phase C, stirring and dissolving, and uniformly mixing to obtain the cosmetic water containing the anti-aging composition.
Examples 5.1 to 5.3
A facial mask essence containing antiaging composition comprises the following raw materials in proportion as shown in Table 2.
Table 2 facial mask essence containing the anti-aging composition component ratio (unit: mass%)
The preparation process flow of the facial mask essence containing the anti-aging composition in the embodiment 5.1-5.3 of the invention is as follows:
1) Sequentially adding the raw materials of phase A into a main tank, heating to 60 ℃, stirring, mixing, dissolving uniformly;
2) Cooling to 30-40 ℃, sequentially adding the phase B and the phase C, stirring and dissolving, and uniformly mixing to obtain the facial mask essence containing the anti-aging composition.
Examples 6.1 to 6.3
A cream comprising an anti-aging composition comprises the raw materials in the proportions shown in Table 3 below.
Table 3 formulation of the cream components comprising the anti-aging composition (unit: mass%)
The preparation process flow of the cream comprising the anti-aging composition of examples 6.1-6.3 of the present invention is as follows:
1) The A phase and B phase raw materials are respectively stirred and heated to 80 ℃;
2) Adding phase B into phase A at 80deg.C, homogenizing for 10min;
3) Cooling to 45deg.C in water bath under stirring, sequentially adding D phase, E phase and C phase, stirring, and cooling to below 35deg.C to obtain cream containing antiaging composition.
Effect verification test example
Stability test of vesicle wrap 1
1. Test article: examples 1 to 3;
2. test instrument: performing particle size distribution test on a test object by a transmission electron microscope and Dynamic Light Scattering (DLS);
3. the test principle is as follows: the stability of the vesicle wrap is judged by determining whether the particle size of the vesicle wrap is changed after being placed for a period of time at a certain temperature. Particle size stability represents vesicle wrap stability;
4. the test indexes are as follows: storing the test object in 30 ℃ environment, and measuring average particle sizes of D0, D3, D7, D14 and D28;
5. the test results are shown in Table 4 and FIG. 1 below
TABLE 4 average particle size of vesicle wrap (μm)
| D0 | D3 | D7 | D14 | D28 | |
| Example 1 | 0.63 | 0.62 | 0.63 | 0.62 | 0.62 |
| Example 2 | 0.78 | 0.77 | 0.79 | 0.78 | 0.77 |
| Example 3 | 0.57 | 0.56 | 0.57 | 0.58 | 0.56 |
The invention uses nonionic surfactant to form vesicle material and adds cholesterol, and uses the filling effect of cholesterol to make the vesicle material fill in the molecular pores formed by active agent monomer, so that it can give certain rigidity to double-layer film and can raise stability of vesicle wrapping material.
The test results show that the particle size change rate of the vesicle wrappers of the embodiment of the invention is within 3% after the vesicle wrappers are stored for a period of time, which proves that the vesicle wrappers of the invention have stability.
Anti-aging Effect test 2
1. The tester: 20 healthy persons (25-55 years old), women, were randomized into two groups, one group using example 4.1 with the composition of example 1 added as the efficacy group and the other group using the sample with the blank added as the control group; the face has no obvious redness, skin damage, scars and the like;
2. test part: full face;
3. test instrument: visia-CR is used for facial image acquisition and wrinkle analysis.
4. The test indexes are as follows: skin wrinkle area rate of change; rate of change = (post-use measurement-pre-use measurement)/(pre-use measurement x 100%;
5. the test results are shown in table 5 below and in fig. 2 to 3:
surface 5 comparison of the area ratio of facial skin wrinkles
| D0 | D7 | D14 | D28 | D56 | |
| Efficacy group | 2.34 | 2.21 | 2.10 | 1.86 | 1.72 |
| Control group | 2.36 | 2.36 | 2.35 | 2.31 | 2.30 |
The skin wrinkle area ratio (table 5 and fig. 2) at five time points of D0, D7, D14, D28, D56 measured according to the Visia-CR, revealed that the skin wrinkle area was reduced by 5.56% after 7 days of use compared to before use; after 14 days of use, the area of skin wrinkles is reduced by 10.26%; after 28 days of use, the wrinkle area is reduced by 20.51%; after 56 days of use, the area of wrinkles is reduced by 26.50%. Compared with the results of the control group, the change rate of the wrinkle area rate of the efficacy group is obviously different after 7 days of use; after 14 days of use, the wrinkle area rate change rate of the efficacy group is remarkably different; after 28 days of use, the change rate of the wrinkle area rate of the efficacy group is remarkably different; after 56 days of use, the change rate of the wrinkle area rate of the efficacy group is significantly different. The partial efficacy group subjects showed a significant reduction in facial skin texture and improved skin smoothness using the front and rear facial image acquisition map (fig. 3).
The above results demonstrate that the example 4.1 efficacy group with the addition of the example 1 anti-aging composition has significant anti-aging effects.
Anti-aging Effect test 3
1. The tester: 20 healthy persons (25-55 years old), women, were randomized into two groups, one group using example.4.1 with the composition of example 1 added as the efficacy group, the other group using the sample with the blank added as the control group; the face has no obvious redness, skin damage, scars and the like;
2. test part: full face;
3. test instrument: an elasticity tester for testing skin tightness and skin elasticity.
4. The test principle is as follows: based on the suction force and the stretching principle, constant negative pressure is applied to the skin to be tested in the vertical direction, then the negative pressure is eliminated, and the displacement change of the skin to be tested in a specified time period is measured, so that the skin elasticity characterization value is obtained. The test calculates the ratio R0 of the residual deformation amount to the maximum elongation of the skin to obtain a skin elasticity value, wherein the R0 value represents the skin extensibility, and the decrease of the R0 value means the decrease of the skin extensibility and the decrease of the stretching degree, and represents the improvement of the skin compactness. The R2 value represents the total skin elasticity and the R2 value increases, representing an increase in skin elasticity.
5. Test results: as shown in tables 6 and 7 and fig. 4 and 5.
TABLE 6 R0 value change Rate
TABLE 7 R2 value change Rate
| ΔD7 | ΔD14 | ΔD28 | ΔD56 | |
| Control group | 0.51％ | 0.84％ | 1.52％ | 1.79％ |
| Efficacy group | 2.97％ | 7.51％ | 11.28％ | 13.65％ |
The results show that the skin elasticity characterization value R0 after the use of the active group is reduced by 5.97% after 7 days of use compared with that before the use; after 14 days of use, the R0 value decreased by 14.36%; after 28 days of use, the R0 value decreased by 20.62%; after 56 days of use, the R0 value decreased by 24.61%. Compared with the result of the control group, the change rate of the skin elasticity characterization value R0 of the efficacy group is obviously different after 7 days of use; after 14 days of use, the change rate of the skin elasticity characterization value R0 of the efficacy group is significantly different; after 28 days of use, the change rate of the skin elasticity characterization value R0 of the efficacy group is remarkably different; after 56 days of use, the rate of change of the skin elasticity characterization value R0 of the efficacy group is significantly different.
After using the effective group, the skin elasticity characterization value R2 is increased by 2.97% after 7 days of use compared with that before use; after 14 days of use, the R2 value increased by 7.51%; after 28 days of use, the R2 value increased by 11.28%; after 56 days of use, the R2 value increased by 13.65%. Compared with the result of the control group, the change rate of the skin elasticity characterization value R2 of the efficacy group is obviously different after 7 days of use; after 14 days of use, the change rate of the skin elasticity characterization value R2 of the efficacy group is significantly different; after 28 days of use, the change rate of the skin elasticity characterization value R2 of the efficacy group is remarkably different; after 56 days of use, the change rate of the skin elasticity characterization value R2 of the efficacy group is significantly different.
The above results demonstrate that the effect of the efficacy group of example 4.1, with the addition of the anti-aging composition of example 1, on the improvement of skin firmness and increase of skin elasticity is evident, and the anti-aging effect is effectively exerted.
Emotion influence effect test 4 of the cosmetic of the present invention
1. The tester: 10 healthy persons (55-65 years old), women, were randomized into two groups, one group using example 4 with the composition of example 1 added as the efficacy group and the other group using the sample with the blank added as the control group; the face has no obvious redness, skin damage, scars and the like;
2. the testing method comprises the following steps: data studies were performed by KBC using AI-based Mindlogics techniques to analyze conscious responses (questionnaires) and subconscious responses (facial expressions).
3. Test results: the results of image acquisition of some subjects are shown in fig. 6, and the efficacy group affects subconscious consciousness of volunteers and promotes emotional health compared with the control group.
Security verification 5
1. Number of test persons: 60 healthy persons (25-55 years old) are randomly divided into 6 groups, and 10 persons in each group are respectively tested in the efficacy group examples of the examples 1-3 and the examples 4-6.
2. Test part: forearm curved side;
3. the testing method comprises the following steps: the selected area is not more than 50mm 2 A suitable plaque tester having a depth of about 1mm is provided with a test object of about 0.020 to 0.025mL (g) by a closed plaque test method. The patch tester was applied to the forearm of the subject, the test substance was removed after 24 hours, and skin reactions were observed at 0.5, 24, and 48 hours after the removal, and the results were recorded according to the skin reaction classification standard in cosmetic safety technical Specification 2015.
4. The evaluation criteria are shown in Table 8 below:
TABLE 8 skin reaction grading criteria
The results show that: the results of the human skin patch test showed that the score levels of 3 observation time points 0.5h, 24h and 48h after patch removal were all 0 points for 6 groups of subjects. According to the regulations of cosmetic safety technology (2015 edition), the test article examples 1 to 6 do not cause adverse skin reactions to the subjects in the present batch.
In conclusion, the anti-aging composition disclosed by the invention has the characteristics of good stability, easy preparation and excellent percutaneous permeability, and the vesicle material is prepared by preparing two nonionic surfactants to encapsulate the rest active ingredients. Through the specific proportion collocation, three functional components penetrate transdermally to the maximum extent, have synergistic effect, protect skin, resist skin aging and oxidative stress, and have no side effect.
Meanwhile, the invention provides application examples of various anti-aging compositions in cosmetics, and the examples can effectively reduce wrinkles, increase elasticity, tighten skin and have obvious anti-aging effect.
In addition, the invention provides a novel characterization method for the application of the anti-aging composition in cosmetics, and the artificial intelligent AI is used for measuring the influence on emotion after the cosmetics using the composition for the first time, so that the positive influence of the anti-aging composition on the skin and the state of a user is further verified. The anti-aging composition and the application example thereof can effectively resist aging and promote the active emotion of a user, thereby improving the anti-aging effect.
The foregoing description is only a preferred embodiment of the present invention and is not intended to limit the invention in any way, so any simple modification, equivalent variation and modification made to the above embodiment according to the technical matter of the present invention will still fall within the scope of the technical scheme of the present invention.
Claims (7)
1. An anti-aging composition, characterized by: the main functional components of the composition are composed of the following components by the total weight of the composition:
10-35% of a sea-tangle extract/a fucus extract/a brewer's yeast extract, 10-35% of a kohlrabi extract/a pullulanase polysaccharide, 10-35% of an alfalfa extract and 0.5-5% of a vesicle material;
the vesicle material is a composite material formed by nonionic surfactant, and the vesicle material is prepared by the nonionic surfactant to wrap other active ingredients;
the anti-aging composition is prepared by the following process:
respectively weighing the extract of the sea stripe algae, the extract of the Fucus vesiculosus, the extract of the beer yeast, the extract of the kohlrabi, the pullulanase polysaccharide, the extract of the alfalfa and the vesicle material according to the mass percentage;
dissolving the extract of sea stripe, fucus vesiculosus, beer yeast, kokumi, pullulanase and alfalfa extract in deionized water containing 0.7% phenoxyethanol to obtain core material solution;
mixing vesicle material with 0.1-5% cholesterol to obtain wall material solution;
placing the core material solution under a homogenizer at a rotating speed of 1500-3000 rpm, slowly pouring the wall material solution into the core material solution after the rotating speed is stable, and continuously stirring for 30-60 min to obtain the anti-aging composition with a particle size range of 0.05-20 mu m.
2. The anti-aging composition of claim 1, wherein: the main functional components of the composition are composed of the following components by the total weight of the composition:
10-30% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 10-30% of kohlrabi extract/pullulanase polysaccharide, 10-30% of alfalfa extract and 0.5-3% of vesicle material.
3. The anti-aging composition of claim 1, wherein: the main functional components of the composition are composed of the following components by the total weight of the composition:
15-25% of sea-tangle extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, 15-25% of kohlrabi extract/pullulanase polysaccharide, 15-25% of alfalfa extract and 1-3% of vesicle material.
4. Use of an anti-aging composition according to any one of claims 1 to 3 for the preparation of a cosmetic product, characterized in that: the anti-aging composition is applied to a cosmetic formula, wherein the anti-aging composition accounts for 1-20% of the total amount of the cosmetic formula, and the cosmetic also comprises conventional auxiliary materials accounting for 80-99% of the total amount of the cosmetic formula.
5. Use of the anti-aging composition according to claim 4 for the preparation of cosmetics, characterized in that: the anti-aging composition accounts for 1-10% of the total amount of the cosmetic formula.
6. Use of the anti-aging composition according to claim 4 or 5 for the preparation of cosmetics, characterized in that: the anti-aging composition accounts for 2-5% of the total amount of the cosmetic formula.
7. Use of the anti-aging composition according to claim 4 for the preparation of cosmetics, characterized in that: the conventional auxiliary materials can be matched with viscosity regulators, emollients, moisturizers, chelating agents, skin-feel conditioning agents, emulsifying agents, preservatives and essence according to different skin-feel requirements; preparing cosmetic water, facial mask, gel, essence, lotion or cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111397926.5A CN114366698B (en) | 2021-11-23 | 2021-11-23 | Anti-aging composition, preparation method thereof and application thereof in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111397926.5A CN114366698B (en) | 2021-11-23 | 2021-11-23 | Anti-aging composition, preparation method thereof and application thereof in cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114366698A CN114366698A (en) | 2022-04-19 |
| CN114366698B true CN114366698B (en) | 2024-01-26 |
Family
ID=81138249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111397926.5A Active CN114366698B (en) | 2021-11-23 | 2021-11-23 | Anti-aging composition, preparation method thereof and application thereof in cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114366698B (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747006A (en) * | 1997-05-14 | 1998-05-05 | Amway Corporation | Skin whitener composition containing acerola cherry fermentate |
| KR20120081788A (en) * | 2011-01-12 | 2012-07-20 | (주) 뉴트리바이오텍 | A cosmetic composition containing acerola extract powder coated with silicone oil mixture |
| CN107397697A (en) * | 2017-08-30 | 2017-11-28 | 永安康健药业（武汉）有限公司 | A kind of whitening spot-eliminating composition and its application |
| CN107510633A (en) * | 2017-09-29 | 2017-12-26 | 上海雨淑缇化妆品有限公司 | A kind of ocular cell assigns anti-ageing Essence living and preparation method thereof |
| CN109044921A (en) * | 2018-10-30 | 2018-12-21 | 武汉百思凯瑞生物科技有限公司 | One kind is anti-ageing to convey nano-lipid vesica and its preparation method and application altogether |
| CN111228130A (en) * | 2019-10-28 | 2020-06-05 | 北京皓尔生物科技有限公司 | Composition with skin cell energy stimulating and skin barrier repairing effects and preparation method and application thereof |
| CN111437237A (en) * | 2020-06-02 | 2020-07-24 | 华南协同创新研究院 | Skin care composition with antioxidant, anti-saccharification and anti-aging effects and application thereof |
| CN111789800A (en) * | 2020-08-14 | 2020-10-20 | 郑州凯莉莱生物科技有限公司 | Aloe composite repair factor and preparation method thereof |
| CN112386507A (en) * | 2020-12-09 | 2021-02-23 | 广州科缇生物科技有限公司 | Preparation method of vesicle-type carrier and application of vesicle-type carrier in cosmetics |
| CN112915045A (en) * | 2021-02-07 | 2021-06-08 | 广州市科能化妆品科研有限公司 | Composition for lifting and tightening skin and preparation method and application thereof |
| CN113143840A (en) * | 2021-03-24 | 2021-07-23 | 湖北省麦诗特生物科技有限公司 | Facial mask composition containing marine-source skin DNA repair cell anti-aging compound and preparation method thereof |
-
2021
- 2021-11-23 CN CN202111397926.5A patent/CN114366698B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747006A (en) * | 1997-05-14 | 1998-05-05 | Amway Corporation | Skin whitener composition containing acerola cherry fermentate |
| KR20120081788A (en) * | 2011-01-12 | 2012-07-20 | (주) 뉴트리바이오텍 | A cosmetic composition containing acerola extract powder coated with silicone oil mixture |
| CN107397697A (en) * | 2017-08-30 | 2017-11-28 | 永安康健药业（武汉）有限公司 | A kind of whitening spot-eliminating composition and its application |
| CN107510633A (en) * | 2017-09-29 | 2017-12-26 | 上海雨淑缇化妆品有限公司 | A kind of ocular cell assigns anti-ageing Essence living and preparation method thereof |
| CN109044921A (en) * | 2018-10-30 | 2018-12-21 | 武汉百思凯瑞生物科技有限公司 | One kind is anti-ageing to convey nano-lipid vesica and its preparation method and application altogether |
| CN111228130A (en) * | 2019-10-28 | 2020-06-05 | 北京皓尔生物科技有限公司 | Composition with skin cell energy stimulating and skin barrier repairing effects and preparation method and application thereof |
| CN111437237A (en) * | 2020-06-02 | 2020-07-24 | 华南协同创新研究院 | Skin care composition with antioxidant, anti-saccharification and anti-aging effects and application thereof |
| CN111789800A (en) * | 2020-08-14 | 2020-10-20 | 郑州凯莉莱生物科技有限公司 | Aloe composite repair factor and preparation method thereof |
| CN112386507A (en) * | 2020-12-09 | 2021-02-23 | 广州科缇生物科技有限公司 | Preparation method of vesicle-type carrier and application of vesicle-type carrier in cosmetics |
| CN112915045A (en) * | 2021-02-07 | 2021-06-08 | 广州市科能化妆品科研有限公司 | Composition for lifting and tightening skin and preparation method and application thereof |
| CN113143840A (en) * | 2021-03-24 | 2021-07-23 | 湖北省麦诗特生物科技有限公司 | Facial mask composition containing marine-source skin DNA repair cell anti-aging compound and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 刘卫 等.《经皮给药纳米技术》.中国医药科学技术出版社,2020,(第1版),第20页. * |
| 培冈.《带着我去化妆品柜台》.新世界出版社,2009,(第1版),930. * |
| 孟胜男 等.《药剂学》.中国医药科技出版社,2016,(第1版),第335-336页. * |
| 王建新.《化妆品植物原料大全》.中国纺织出版社,2012,(第1版),482. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114366698A (en) | 2022-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105687055B (en) | A kind of eye maintenance Essence and preparation method thereof | |
| CN111529417B (en) | Repairing eye cream with blue light resisting effect and preparation method thereof | |
| CN110693807B (en) | Skin bottom essence and preparation method thereof | |
| CN111789777A (en) | Skin care cream with immediate tightening and anti-aging effects and preparation method thereof | |
| CN110638709A (en) | Anti-blue-light multi-effect repair eye cream and preparation method thereof | |
| CN109602648A (en) | A kind of composition and its preparation method and application with reparation and senile-resistant efficacy | |
| CN111450010A (en) | Composition with anti-aging effect and application thereof in cosmetics | |
| CN113117051B (en) | Anti-aging transdermal polypeptide preparation and preparation method thereof | |
| CN112402345A (en) | Deep moisturizing composition, cosmetics and preparation method thereof | |
| CN114931543B (en) | Repairing and anti-aging essence with high content of blue copper peptide and preparation method thereof | |
| CN110721148A (en) | Multidirectional pulling and tightening polypeptide essence and preparation method thereof | |
| CN111920730A (en) | Repairing moisturizing cream and preparation method thereof | |
| CN115844748A (en) | Eye composition and preparation method and application thereof | |
| CN113768853A (en) | Whitening and spot-fading composition as well as preparation method and application thereof | |
| CN111434332A (en) | Nourishing and repairing emulsion and preparation method thereof | |
| CN112263528A (en) | Collagen jelly mask and preparation and use methods thereof | |
| CN114366698B (en) | Anti-aging composition, preparation method thereof and application thereof in cosmetics | |
| CN114159333B (en) | Myobase liquid and preparation method thereof | |
| CN114288201B (en) | Composition for removing pouch and fading black eye, and preparation method and application thereof | |
| CN110025515B (en) | Anti-allergy polysaccharide compound composition and application thereof in cosmetics | |
| CN114272184A (en) | Polypeptide composition, anti-aging repair eye cream containing polypeptide composition and preparation method of anti-aging repair eye cream | |
| CN110721102A (en) | Eye mask with moisturizing, anti-wrinkle and anti-oxidation effects | |
| CN114073645A (en) | A skin care composition containing mineral components and its preparation method | |
| CN107375029B (en) | Anti-allergy moisturizing emulsion containing camellia seed oil | |
| CN115813826B (en) | Compact anti-wrinkle composition and application thereof in cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |