CN114366698A - Anti-aging composition, preparation method thereof and application thereof in cosmetics - Google Patents
Anti-aging composition, preparation method thereof and application thereof in cosmetics Download PDFInfo
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- CN114366698A CN114366698A CN202111397926.5A CN202111397926A CN114366698A CN 114366698 A CN114366698 A CN 114366698A CN 202111397926 A CN202111397926 A CN 202111397926A CN 114366698 A CN114366698 A CN 114366698A
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses an anti-aging composition, a preparation method thereof and application thereof in cosmetics. The anti-aging composition is composed of the following functional raw materials in percentage by mass: 10-40% of extract of Laticauda elongata/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, 10-40% of extract of acerola/pullulanase, 10-40% of extract of Medicago sativa, and 0.1-5% of vesicle material. The anti-aging composition is prepared into a vesicle material by a non-ionic surfactant to wrap the rest active ingredients, and has the characteristics of easy preparation and more excellent percutaneous permeability compared with the traditional liposome material; through specific proportion matching, the three functional components have the functions of maximum percutaneous penetration and synergistic effect, protect the skin, and resist skin aging and oxidative stress, so that the skin is healthier.
Description
Technical Field
The invention relates to a cosmetic composition, a preparation method thereof and application thereof in cosmetics, belongs to the technical field of daily chemicals, and more particularly relates to an anti-aging composition, a preparation method thereof and application thereof in cosmetics.
Background
The cosmetics are used for a long time, and along with the continuous improvement of the living standard of the substances of people, the skin care requirements of people are higher and higher, and particularly, the application population of the anti-aging products is wider and wider. Through the trend that people over 30 years old gradually become younger, the anti-aging consciousness of people is mature, and consumers can also believe and concur the basic anti-aging mechanisms of 'anti-saccharification, anti-photoaging and anti-free radical … …', so that anti-aging cosmetics are paid more and more attention.
However, the existing cosmetics generally have short plates with poor transdermal absorption effect, which is specifically shown as remarkable in vitro effect, but slow or no obvious effect exists in human body effect. Meanwhile, some active ingredients with good anti-aging effect have application limitations such as large irritation or poor stability.
Therefore, a mild and safe anti-aging product with remarkable effect is needed.
Disclosure of Invention
The invention aims to provide a formula of an anti-aging composition and a preparation method thereof, wherein a vesicle material prepared by a non-ionic surfactant wraps other active ingredients, and compared with the traditional liposome material, the anti-aging composition has the characteristics of easy preparation and better percutaneous permeability; through specific proportion matching, the three functional components have the functions of maximum percutaneous penetration and synergistic effect, protect the skin, and resist skin aging and oxidative stress, so that the skin is healthier.
The invention also aims to provide the application of the anti-aging composition in cosmetics, and the three functional components have the maximum transdermal penetration and the synergistic effect, so that the skin is protected, the skin aging and oxidative stress are resisted, and the skin is healthier.
The technical scheme of the invention is as follows:
an anti-aging composition comprises the following main functional components in percentage by mass:
10-40% of extract of Laticauda elongata/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, 10-40% of extract of acerola/pullulanase, 10-40% of extract of Medicago sativa, and 0.1-5% of vesicle material.
Further, the anti-aging composition mainly comprises the following functional raw materials in percentage by mass:
10-35% of extract of Zostera marina, 10-35% of extract of Fucus vesiculosus, 10-35% of extract of Emilia javanica, 10-35% of Aureobasidium pullulans, 10-35% of extract of Medicago sativa, and 0.5-5% of vesicle material.
Further, the anti-aging composition mainly comprises the following functional raw materials in percentage by mass:
10-30% of extract of Zostera marina, 10-30% of extract of Fucus vesiculosus, 10-30% of extract of acerola, 10-30% of polysaccharide of Aureobasidium pullulans, 10-30% of extract of Medicago sativa, and 0.5-3% of vesicle material.
Further, the anti-aging composition mainly comprises the following functional raw materials in percentage by mass:
the sea algae extract/fucus extract/saccharomyces cerevisiae extract 15-25%, acerola extract/pullulanase 15-25%, alfalfa extract 15-25% and vesicle material 1-3%.
Furthermore, the composite material of the vesicle material composed of the nonionic surface activity can be easily formed into the vesicle only by diluting with water and stirring, and has the advantages of easy preparation, excellent percutaneous permeability of the formed vesicle and high stability over time.
Specifically, the preparation process of the anti-aging composition comprises the following steps:
respectively weighing the extract of the algae Lasiocladia elongata, the extract of the fucus vesiculosus, the extract of the Saccharomyces cerevisiae, the extract of the acerola/the pullulanase, the extract of the Medicago sativa and the vesicle material according to the mass percentage.
Dissolving the extract of Laplace elongata/Fucus vesiculosus/Saccharomyces cerevisiae, the extract of acerola/Aureobasidium pullulans and the extract of Medicago sativa in deionized water containing 0.7% phenoxyethanol to obtain core material solution.
Mixing the vesicle material with 0.1-5% cholesterol to obtain wall material solution.
And (3) placing the core material solution under a homogenizer at the rotation speed of 1500-3000 rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 30-60 min to obtain the anti-aging composition with the particle size of 0.05-20 mu m.
The anti-aging composition comprises the following functional components: the Sargassum extensum extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract is prepared from two brown algae water extracts (Sargassum extensum and Fucus vesiculosus) and selenium-rich Saccharomyces cerevisiae extract, and has excellent antioxidant property and mutual complementary and synergistic effect.
Due to the three-dimensional and high-molecular-weight configuration of the acerola extract/pullulanase, the acerola extract/pullulanase can be well attached to a skin micro-area, and the effects of smoothness, compactness and lifting can be immediately seen on the surface of the skin.
The alfalfa extract has metabolic stimulation to both the epidermis and dermis layers of the skin, exhibits retinoid wrinkle-removing activity, and does not produce any side effects.
The vesicle material is prepared by non-ionic surfactant, and can improve the transdermal permeability of active ingredients. Different from the traditional liposome material, the vesicle is easier to prepare, the transdermal permeability is better, and a small amount of cholesterol is added to fill in molecular pores formed by active agent monomers, so that the bilayer membrane of the vesicle is endowed with certain rigidity, the stability is higher along with the time, and the full exertion of the effective components is promoted. Through specific proportion matching, the three functional components have the functions of maximum percutaneous penetration and synergistic effect, protect the skin, and resist skin aging and oxidative stress, so that the skin is healthier.
Use of an anti-aging composition in cosmetics. The anti-aging composition accounts for 1-20% of the total amount of the cosmetic formula, preferably ranges from 1-10%, and most preferably ranges from 2-5%. The cosmetic also comprises conventional auxiliary materials accounting for 80-99% of the total amount of the formula of the cosmetic, and can be matched with certain viscosity regulators, emollients, humectants, chelating agents, skin-feel conditioning agents, emulsifiers, preservatives, essences and the like according to different skin-feel requirements, and prepared into astringent, facial mask, gel, essence, emulsion and cream so as to meet the requirements of ideal dosage form, skin feel and efficacy.
The invention also provides a new characterization method for applying the anti-aging composition in cosmetics, the artificial intelligence AI is used for the first time to measure the influence on the mood after the cosmetics using the composition relate to the neurological category, and the positive influence of the anti-aging composition on the skin and the state of a user is further verified.
By means of the technical scheme, the invention has the following advantages and beneficial technical effects:
1) the anti-aging composition overcomes the problems of poor transdermal absorption, slow effect taking or no obvious effect generally existing in anti-aging products on the market, improves the transdermal permeability of active ingredients by a vesicle material consisting of nonionic surfactants, and has more remarkable and faster effect taking.
2) The anti-aging composition disclosed by the invention consists of a striped seaweed extract/a fucus extract/a saccharomyces cerevisiae extract, a acerola cupreum extract/a pullulanase polysaccharide and a medicago sativa extract, has excellent anti-oxidation, anti-free radical and anti-aging effects, can be comparable to the effects of vitamin A and vitamin C which are traditional effect substances, but has no biostimulation, is milder and safer, has better product stability, has no discoloration and instability risks, and is easier to apply to skin care products.
3) The anti-aging composition obtained by specific proportioning and combination protects the skin from the external environment stress source by resisting oxidative stress and heavy metal induced stress reaction from the aspect of epidermis protection. In addition, the collagen peptide can promote the proliferation of fibroblasts, improve the activity of cells, promote the synthesis of collagen I and hyaluronic acid, further relieve the pressure of a molecular network and consolidate the structure of a matrix. Finally, the skin state of the face is comprehensively improved, and the face contour is more compact and shapeable.
4) The application of the anti-aging composition in cosmetics tests the influence of the product on emotion by using an artificial intelligent AI technology for the first time, and relates to the category of neurology. The results demonstrate that the use of a product to which an anti-aging composition is added affects the subconscious emotional well-being of a human, further demonstrating the effectiveness of the anti-aging product.
Drawings
FIG. 1 shows the rate of change of average vesicle particle size of the composition of example 1;
FIG. 2 shows the rate of change of the skin wrinkle area ratio of the efficacy group and the control group using example 4;
FIG. 3 shows a VISIA facial image acquisition of a portion of a subject using the efficacy group of example 4;
FIG. 4 shows the rate of change in skin elasticity R0 values using the efficacy group of example 4 and the control group;
FIG. 5 shows the rate of change in skin elasticity R2 values using the efficacy group of example 4 and the control group;
figure 6 shows a facial emotion collection for a portion of subjects using the efficacy group of example 4 versus the control group.
Detailed Description
The invention discloses an anti-aging composition and a preparation method thereof. The anti-aging composition comprises the following main functional components:
10-40% of extract of Laticauda elongata/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, 10-40% of extract of acerola/pullulanase, 10-40% of extract of Medicago sativa, and 0.1-5% of vesicle material.
Extract of sea algae, fucus extract, beer yeast extract
The raw material components are as follows: the extract of the algae Lasiocladia elongata, the extract of the Fucus vesiculosus and the extract of the Saccharomyces cerevisiae can activate an anti-stress gene regulation network, promote a homeostatic pathway (homeostatic pathways), and contribute to enhancing the cell detoxification function and protecting cells from cascade reactions affected by harmful environments. Can maximize the adaptive capacity of cells and make the skin better resist the invasion and the injury. The raw material components are described in Chinese invention patent application, and a facial mask composition containing marine-derived skin DNA repair cell anti-aging compound and a preparation method thereof (application number CN202110312378.5) are provided.
In an embodiment of the invention, the extract of the algae striped: fucus vesiculosus extract: the mass ratio of the saccharomyces cerevisiae extract to the saccharomyces cerevisiae extract is 0.5-1.5: 2.0-5.0: 1.5-4.0.
② acerola extract/pullulanase polysaccharide
The ACEROLA FRUIT EXTRACT is MALPIGHIA EMARGINATA (Acerola) FRUIT EXTRACT, has the main function of an antioxidant in cosmetics and skin care products, has a risk coefficient of 1, is relatively safe, can be used safely, has no influence on pregnant women generally, and has no pox-causing property.
The acerola extract has effects of promoting epidermal cell activity, activating skin, and resisting oxidation, and can be used in antiaging cosmetic.
Pullulanase, whose english name is PULLULAN, alternative name: pullulan, Aureobasidium pullulans, pullulan and pullulan. The pullulanase mainly acts as a film-forming agent in cosmetics and skin care products.
In the embodiment of the invention, the mass ratio of the acerola extract to the pullulanase is 1.5-5.0: 2.0-4.0.
③ Medicago sativa extract
The alfalfa extract is rich in galactomannans and enhances disturbed cellular activities due to the aging process. By regulating keratinocyte differentiation, epidermal renewal can be promoted. It has effects of protecting and repairing dermis by stimulating synthesis of collagen I and weakening activity of metalloprotease causing destruction of elastic fiber.
Vesicle material
The vesicle material is a composite material formed by nonionic surface activity, can be easily formed into vesicles only by diluting with water and stirring, and has the advantages of easy preparation, excellent percutaneous permeability of the formed vesicles and high stability over time.
The commercially available product Nikkosome PV, available from NIPPON SURFAC-TANT, Japan, is used in the examples of the present invention and is a vesicle material having excellent percutaneous permeability. It is a clear/translucent liquid with a faint characteristic odor.
The components of the composition comprise the following components in the range: glycerol (CAS No.56-81-5) 65-80%; polyglycerin-10 diisostearate, (CAS No.102033-55-6) 0-15%; 0-10% of polyglycerol-10 laurate (CAS No. 34406-66-1); 10-25% of water.
In conclusion, the selected functional substance of the invention, namely the extract of the kelp seaweed/the extract of the fucus vesiculosus/the extract of the saccharomyces cerevisiae, has excellent anti-oxidation property; acerola extract/pullulanase has three-dimensional and high molecular weight configuration, and can remarkably smooth and compact skin; the alfalfa extract is rich in galactomannan and exhibits retinoid wrinkle-removing activity without any side effects.
The present invention is illustrated by the following examples, which are provided for the purpose of further illustration only and are not intended to limit the scope of the present invention. Other insubstantial modifications and adaptations of the present invention can be made without departing from the scope of the present invention. Unless otherwise specified, the following percentages (%) are mass percentages. The raw material components used in the embodiment of the invention are all commercial products.
Example 1
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
the core material comprises the following components: the seaweed extract comprises 24% of the extract of the Lawsonia inermis, 24% of the extract of the malpighia glabra, 24% of the extract of the purple alfalfa and 24.7% of deionized water containing 0.7% of phenoxyethanol.
The manufacturing process comprises the following steps: accurately weighing the core material components in proportion: sargassum elongatum extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, Rhinocarpus japonicas extract/Aureobasidium pullulans polysaccharide, and herba Medicaginis extract.
Dissolving the core material components in deionized water containing 0.7% phenoxyethanol to obtain a core material solution. Accurately weighing wall material components in proportion: and mixing the vesicle material with cholesterol to obtain a wall material solution.
And (3) placing the core material solution under a homogenizer at the rotating speed of 2000rpm, slowly pouring the wall material solution into the core material solution after the rotating speed is stable, and continuously stirring for 45min to obtain the anti-aging composition with the particle size range (0.5 +/-0.1) mu m.
The preparation method of the embodiment is simple and suitable for large-scale popularization, and the prepared anti-aging composition has the characteristics of good anti-aging effect, safety, mildness, slow release and the like.
Example 2
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
the core material comprises the following components: sargassum elongatum extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract 15%, Rhinocarpus japonicas extract/Aureobasidium pullulans polysaccharide 22%, herba Medicaginis extract 18%, and deionized water containing 0.7% phenoxyethanol 41.7%.
The manufacturing process comprises the following steps: accurately weighing the core material components in proportion: sargassum elongatum extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, Rhinocarpus japonicas extract/Aureobasidium pullulans polysaccharide, and herba Medicaginis extract.
Dissolving the core material components in deionized water containing 0.7% phenoxyethanol to obtain a core material solution. Accurately weighing wall material components in proportion: and mixing the vesicle material with cholesterol to obtain a wall material solution.
And (3) placing the core material solution under a homogenizer at the rotation speed of 2500rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain the anti-aging composition with the particle size range (0.5 +/-0.1) mu m.
The preparation method of the embodiment is simple and suitable for large-scale popularization, and the prepared anti-aging composition has the characteristics of good anti-aging effect, safety, mildness, slow release and the like.
Example 3
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
the core material comprises the following components: sargassum elongatum extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract 15%, Rhinocarpus japonicas extract/Aureobasidium pullulans 15%, herba Medicaginis extract 15%, and deionized water containing 0.7% phenoxyethanol 51.7%.
The manufacturing process comprises the following steps: accurately weighing the core material components in proportion: sargassum elongatum extract/Fucus vesiculosus extract/Saccharomyces cerevisiae extract, Rhinocarpus japonicas extract/Aureobasidium pullulans polysaccharide, and herba Medicaginis extract.
Dissolving the core material components in deionized water containing 0.7% phenoxyethanol to obtain a core material solution. Accurately weighing wall material components in proportion: and mixing the vesicle material with cholesterol to obtain a wall material solution.
And (3) placing the core material solution under a homogenizer at the rotation speed of 2500rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain the anti-aging composition with the particle size range (0.5 +/-0.1) mu m.
The preparation method of the embodiment is simple and suitable for large-scale popularization, and the prepared anti-aging composition has the characteristics of good anti-aging effect, safety, mildness, slow release and the like.
Blank example
An anti-aging composition comprises the following components in percentage by mass:
the wall material comprises the following components: 3% of vesicle material and 0.3% of cholesterol;
the core material comprises the following components: contains 0.7 percent of phenoxyethanol and 96.7 percent of deionized water.
The manufacturing process comprises the following steps: accurately weighing the core material component containing 0.7 percent phenoxyethanol deionized water according to the proportion to obtain the core material solution. Accurately weighing wall material components in proportion: and mixing the vesicle material with cholesterol to obtain a wall material solution.
And (3) placing the core material solution under a homogenizer at the rotation speed of 2500rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 45min to obtain a blank control example with the particle size range (0.5 +/-0.1) mu m.
Examples 4.1 to 4.3
The contents of the raw material components of the toning lotion containing the anti-aging composition according to the proportion are shown in the following table 1.
TABLE 1 ratio of ingredients of astringent raw materials containing antiaging composition (unit: mass%)
The preparation process flow of the toning lotion containing the anti-aging composition in the embodiments 4.1 to 4.3 of the invention is as follows:
1) sequentially adding the phase A raw materials into a main tank, stirring, mixing and dissolving uniformly;
2) sequentially adding phase B and phase C, stirring for dissolving, and mixing to obtain cosmetic lotion containing antiaging composition.
Examples 5.1 to 5.3
The facial mask essence containing the anti-aging composition comprises the following raw material components in percentage by weight as shown in table 2.
Table 2 facial mask essence composition ratio (unit: mass%) containing the anti-aging composition
The preparation process flow of the mask essence containing the anti-aging composition of the embodiment 5.1-5.3 of the invention is as follows:
1) sequentially adding the phase A raw materials into a main tank, heating to 60 ℃, stirring, mixing and dissolving uniformly;
2) and cooling to 30-40 ℃, sequentially adding the phase B and the phase C, stirring for dissolving, and uniformly mixing to obtain the facial mask essence containing the anti-aging composition.
Examples 6.1 to 6.3
The cream containing the anti-aging composition comprises the following raw material components in proportion as shown in table 3.
TABLE 3 cream component ratio (unit: mass%) containing anti-aging composition
The cream containing the anti-aging composition of the embodiments 6.1 to 6.3 of the invention has the following preparation process flow:
1) respectively stirring and heating the raw materials of the phase A and the phase B to 80 ℃;
2) adding phase B into phase A at 80 deg.C, and homogenizing for 10 min;
3) cooling to 45 deg.C under stirring in water bath, sequentially adding phase D, phase E and phase C, stirring, and cooling to below 35 deg.C to obtain cream containing antiaging composition.
Test example for Effect verification
Vesicle packagingPhysical stability test 1
1. Test article: examples 1 to 3;
2. testing an instrument: carrying out particle size distribution test on the test object by a transmission electron microscope and Dynamic Light Scattering (DLS);
3. the test principle is as follows: the stability of the vesicle wrap is judged by measuring whether the particle size is changed after the vesicle wrap is placed for a period of time at a certain temperature. The stable particle size represents the stability of the vesicle wrap;
4. testing indexes are as follows: storing the test substance in an environment of 30 deg.C, and measuring average particle diameter at D0, D3, D7, D14 and D28;
5. the test results are shown in Table 4 below and FIG. 1
TABLE 4 average particle size (μm) of vesicle envelope
| D0 | D3 | D7 | D14 | D28 | |
| Example 1 | 0.63 | 0.62 | 0.63 | 0.62 | 0.62 |
| Example 2 | 0.78 | 0.77 | 0.79 | 0.78 | 0.77 |
| Example 3 | 0.57 | 0.56 | 0.57 | 0.58 | 0.56 |
The invention uses the nonionic surfactant to form the vesicle material, adds the cholesterol, and utilizes the filling effect of the cholesterol to fill the vesicle material in the molecular pores formed by the active agent monomers, thereby endowing the bilayer membrane with certain rigidity and increasing the stability of the vesicle wrap.
Test results show that after the vesicle wrap disclosed by the embodiment of the invention is stored for a period of time, the range of the particle size change rate is within 3%, which indicates that the vesicle wrap disclosed by the invention has stability.
Anti-aging Effect test 2
1. The tester: 20 healthy persons (25-55 years old), female, were randomly divided into two groups, one group using example 4.1 with the composition of example 1 added as the efficacy group, and the other group using the sample with the blank as the control group; the face has no obvious redness, skin damage, scars and other conditions;
2. testing parts: a full face;
3. testing an instrument: Visia-CR was used for facial image acquisition and wrinkle analysis.
4. Testing indexes are as follows: rate of change of skin wrinkle area; change rate ═ (after use measure-before use measure) ÷ before use measure × 100%;
5. the test results are shown in the following table 5 and fig. 2 to 3:
TABLE 5 comparison of wrinkle area ratio of facial skin
| D0 | D7 | D14 | D28 | D56 | |
| Efficacy group | 2.34 | 2.21 | 2.10 | 1.86 | 1.72 |
| Control group | 2.36 | 2.36 | 2.35 | 2.31 | 2.30 |
Skin wrinkle area rates at five time points D0, D7, D14, D28, D56 measured according to Visia-CR (table 5 and fig. 2) showed a 5.56% reduction in skin wrinkle area after 7 days of use compared to before use after use in the efficacy group; after 14 days of use, the skin wrinkle area was reduced by 10.26%; after 28 days of use, the wrinkle area was reduced by 20.51%; after 56 days of use, the wrinkle area was reduced 26.50%. Compared with the result of using a control group, the wrinkle area rate change rate of the efficacy group is obviously different after 7 days of use; after 14 days of use, the wrinkle area rate change rate of the efficacy group has significant difference; after the skin-care product is used for 28 days, the wrinkle area rate change rate of the efficacy group has obvious difference; after 56 days of use, the wrinkle area rate change rate of the efficacy group is obviously different. The facial image acquisition (fig. 3) before and after the use of the subjects in the partial efficacy group showed that the facial skin lines were much reduced and the skin smoothness was improved.
The above results show that the efficacy group of example 4.1 added with the anti-aging composition of example 1 has a significant anti-aging effect.
Anti-aging Effect test 3
1. The tester: 20 healthy persons (25-55 years old), female, were randomly divided into two groups, one group using the example with the composition of example 1 added.4.1 as efficacy group, and the other group using the sample with blank as control group; the face has no obvious redness, skin damage, scars and other conditions;
2. testing parts: a full face;
3. testing an instrument: and the elasticity tester is used for testing the skin tightness and the skin elasticity.
4. The test principle is as follows: based on the suction and stretching principle, constant negative pressure is applied to the skin to be tested in the vertical direction, then the negative pressure is eliminated, and the displacement change of the skin to be tested in a specified time period is measured to obtain a skin elasticity characterization value. The test obtains the skin elasticity value by calculating the ratio R0 of the residual deformation amount to the maximum elongation amount of the skin, wherein the R0 value represents the skin extensibility, and the decrease of the R0 value means the decrease of the skin extensibility and the elongation and represents the increase of the skin tightness. The R2 value represents total skin elasticity, and the R2 value, which represents increased skin elasticity.
5. And (3) testing results: as shown in tables 6 and 7 and fig. 4 and 5.
TABLE 6 Rate of change of values of R0
TABLE 7 Rate of change of values of R2
| ΔD7 | ΔD14 | ΔD28 | ΔD56 | |
| Control group | 0.51％ | 0.84％ | 1.52％ | 1.79％ |
| Efficacy group | 2.97％ | 7.51％ | 11.28％ | 13.65％ |
The results show that the skin elasticity characteristic value R0 after the use of the efficacy group is reduced by 5.97% after 7 days of use compared with that before use; after 14 days of use, the R0 value decreased by 14.36%; after 28 days of use, the R0 value decreased 20.62%; after 56 days of use, the R0 value decreased by 24.61%. Compared with the results of the control group, the change rate of the skin elasticity characteristic value R0 of the efficacy group is significantly different after 7 days of use; after 14 days of use, the change rate of the skin elasticity characteristic value R0 of the efficacy group is significantly different; after 28 days of use, the change rate of the skin elasticity characteristic value R0 of the efficacy group is significantly different; after 56 days of use, the change rate of the skin elasticity characteristic value R0 of the efficacy group is significantly different.
After the efficacy group is used, the skin elasticity characteristic value R2 is compared with that before the use, and after the use for 7 days, the R2 value is increased by 2.97 percent; after 14 days of use, the R2 value increased by 7.51%; after 28 days of use, the R2 value increased 11.28%; after 56 days of use, the R2 value increased 13.65%. Compared with the results of the control group, the change rate of the skin elasticity characteristic value R2 of the efficacy group is significantly different after 7 days of use; after 14 days of use, the change rate of the skin elasticity characteristic value R2 of the efficacy group is significantly different; after 28 days of use, the change rate of the skin elasticity characteristic value R2 of the efficacy group is significantly different; after 56 days of use, the change rate of the skin elasticity characteristic value R2 of the efficacy group is significantly different.
The above results show that the efficacy group of example 4.1 added with the anti-aging composition of example 1 has a significant effect of increasing the firmness and elasticity of the skin, and effectively exerts the anti-aging effect.
Effect of the cosmetic of the present invention on mood test 4
1. The tester: 10 healthy persons (55-65 years old), women, randomly divided into two groups, one group using example 4 with the composition of example 1 added as the efficacy group, and the other group using the sample with the blank added as the control group; the face has no obvious redness, skin damage, scars and other conditions;
2. the test method comprises the following steps: data studies were performed by KBC using the AI-based miniglomics technique to analyze conscious responses (questionnaires) and subconscious responses (facial expressions).
3. And (3) testing results: the image acquisition results of some subjects are shown in fig. 6, and compared with the control group, the efficacy group affects the subconscious of volunteers and promotes healthier emotion.
Security verification 5
1. The number of tested persons: 60 healthy persons (25-55 years old) were randomly divided into 6 groups of 10 persons, and the examples of the efficacy groups of examples 1-3 and examples 4-6 were tried respectively.
2. Testing parts: the curved side of the forearm;
3. the test method comprises the following steps: the selection area is not more than 50mm2And (g) about 0.020 to 0.025mL (g) of a test substance in a closed patch test method in a suitable patch tester having a depth of about 1 mm. The patch tester is applied to the curved side of the forearm of the subject, the subject is removed 24 hours later, the skin reaction is observed 0.5 hour, 24 hours and 48 hours after the removal, and the result is recorded according to the skin reaction grading standard in the technical Specification for cosmetic safety 2015.
4. The evaluation criteria are as follows in table 8:
TABLE 8 grading Standard of skin reactions
The results show that: the results of the human skin patch test show that the score grades of 0.5h, 24h and 48h of 3 observation time points of 6 groups of subjects after patch removal are 0. According to the regulations in the technical Specification for cosmetic safety (2015 edition), the test substance examples 1-6 do not cause adverse skin reactions to the subjects of the batch.
In conclusion, the anti-aging composition has good stability, is prepared by two nonionic surfactants to form a vesicle material to wrap the rest active ingredients, and has the characteristics of easy preparation and excellent percutaneous permeability. Through specific proportion matching, the three functional components have the maximum transdermal penetration and the synergistic effect, protect the skin, resist skin aging and oxidative stress, and have no side effect.
Meanwhile, the invention provides application examples of various anti-aging compositions in cosmetics, and the examples can effectively reduce wrinkles, increase elasticity and tighten skin, and have remarkable anti-aging effect.
In addition, the invention provides a new characterization method for the application of the anti-aging composition in cosmetics, the influence on the mood after the cosmetics using the composition is measured by using artificial intelligence AI for the first time, and the positive influence of the anti-aging composition on the skin and the state of a user is further verified. The anti-aging composition and the application thereof can effectively resist aging and promote the positive emotion of a user, thereby gaining the anti-aging effect.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (9)
1. An anti-aging composition characterized by: the main functional components of the composition are composed of the following components by weight:
10-40% of extract of Laticauda elongata/extract of Fucus vesiculosus/extract of Saccharomyces cerevisiae, 10-40% of extract of acerola/pullulanase, 10-40% of extract of Medicago sativa, and 0.1-5% of vesicle material.
2. The anti-aging composition of claim 1, wherein: the main functional components of the composition are composed of the following components by weight:
10-35% of extract of Zostera marina, 10-35% of extract of Fucus vesiculosus, 10-35% of extract of Emilia javanica, 10-35% of Aureobasidium pullulans, 10-35% of extract of Medicago sativa, and 0.5-5% of vesicle material.
3. The anti-aging composition of claim 1, wherein: the main functional components of the composition are composed of the following components by weight:
10-30% of extract of Zostera marina, 10-30% of extract of Fucus vesiculosus, 10-30% of extract of acerola, 10-30% of polysaccharide of Aureobasidium pullulans, 10-30% of extract of Medicago sativa, and 0.5-3% of vesicle material.
4. The anti-aging composition of claim 1, wherein: the main functional components of the composition are composed of the following components by weight:
the sea algae extract/fucus extract/saccharomyces cerevisiae extract 15-25%, acerola extract/pullulanase 15-25%, alfalfa extract 15-25% and vesicle material 1-3%.
5. The anti-aging composition according to any one of claims 1 to 4, wherein: the vesicle material is a composite material composed of nonionic surface activity.
6. The anti-aging composition of claim 5, wherein: the anti-aging composition is prepared by the following process:
respectively weighing the extract of the algae Lasiocladia elongata/the extract of the fucus vesiculosus/the extract of the saccharomyces cerevisiae, the extract of the acerola/the pullulanase, the extract of the alfalfa and the vesicle material according to the mass percentage;
dissolving the extract of Laplace elongata/Fucus vesiculosus/Saccharomyces cerevisiae, the extract of acerola/Aureobasidium pullulans and the extract of Medicago sativa in deionized water containing 0.7% phenoxyethanol to obtain core material solution;
mixing the vesicle material with 0.1-5% cholesterol to obtain a wall material solution;
and (3) placing the core material solution under a homogenizer at the rotation speed of 1500-3000 rpm, slowly pouring the wall material solution into the core material solution after the rotation speed is stable, and continuously stirring for 30-60 min to obtain the anti-aging composition with the particle size of 0.05-20 mu m.
7. Use of the anti-aging composition according to any one of claims 1 to 6 in cosmetics, characterized in that: the anti-aging composition is applied to a cosmetic formula, the anti-aging composition accounts for 1-20% of the total amount of the cosmetic formula, and the cosmetic further comprises conventional auxiliary materials accounting for 80-99% of the total amount of the cosmetic formula.
8. The use of the anti-aging composition according to claim 7 in cosmetics, characterized by: the anti-aging composition accounts for 1-10% of the total amount of the cosmetic formula, and the preferable range is 2-5%.
9. The use of the anti-aging composition according to claim 7 in cosmetics, characterized by: the conventional auxiliary materials can be matched with a viscosity regulator, an emollient, a humectant, a chelating agent, a skin feeling conditioner, an emulsifier, a preservative and essence according to different skin feeling requirements of the skin; preparations include, but are not limited to, lotions, masks, gels, essences, lotions, and creams.
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