CN114983886A - Anti-allergy soothing composition with skin barrier repair effect - Google Patents
Anti-allergy soothing composition with skin barrier repair effect Download PDFInfo
- Publication number
- CN114983886A CN114983886A CN202210591246.5A CN202210591246A CN114983886A CN 114983886 A CN114983886 A CN 114983886A CN 202210591246 A CN202210591246 A CN 202210591246A CN 114983886 A CN114983886 A CN 114983886A
- Authority
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- China
- Prior art keywords
- ceramide
- alcohol
- skin barrier
- extract
- allergy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 44
- 230000000694 effects Effects 0.000 title claims abstract description 38
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 38
- 230000008439 repair process Effects 0.000 title claims description 28
- 150000004676 glycans Chemical class 0.000 claims abstract description 37
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 37
- 239000005017 polysaccharide Substances 0.000 claims abstract description 37
- 239000000419 plant extract Substances 0.000 claims abstract description 26
- 239000000284 extract Substances 0.000 claims description 42
- 229940106189 ceramide Drugs 0.000 claims description 35
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 31
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 31
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 31
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 30
- 229930182558 Sterol Natural products 0.000 claims description 22
- 150000003432 sterols Chemical class 0.000 claims description 22
- 235000003702 sterols Nutrition 0.000 claims description 22
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- -1 ceramide compound Chemical class 0.000 claims description 17
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 16
- 150000002191 fatty alcohols Chemical class 0.000 claims description 16
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 15
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 14
- 229940099417 ceramide 2 Drugs 0.000 claims description 14
- 229940044176 ceramide 3 Drugs 0.000 claims description 14
- 241001506047 Tremella Species 0.000 claims description 12
- 229940095137 ceramide 6 ii Drugs 0.000 claims description 12
- 235000004347 Perilla Nutrition 0.000 claims description 10
- 229940043348 myristyl alcohol Drugs 0.000 claims description 10
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 10
- 229940012831 stearyl alcohol Drugs 0.000 claims description 10
- 241000207929 Scutellaria Species 0.000 claims description 9
- 229940006091 aloe polysaccharide Drugs 0.000 claims description 9
- 229940059958 centella asiatica extract Drugs 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 8
- 229920002498 Beta-glucan Polymers 0.000 claims description 8
- 241001071795 Gentiana Species 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 6
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 235000002378 plant sterols Nutrition 0.000 claims description 4
- 239000013589 supplement Substances 0.000 claims description 4
- 244000075850 Avena orientalis Species 0.000 claims description 3
- 235000007319 Avena orientalis Nutrition 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- 229960000541 cetyl alcohol Drugs 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 229960000735 docosanol Drugs 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- 229940055577 oleyl alcohol Drugs 0.000 claims description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
- 235000004727 Opuntia ficus indica Nutrition 0.000 claims 1
- 240000009297 Opuntia ficus-indica Species 0.000 claims 1
- 244000124853 Perilla frutescens Species 0.000 claims 1
- 239000008518 lycium barbarum polysaccharide Substances 0.000 claims 1
- 150000001783 ceramides Chemical class 0.000 abstract description 10
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 28
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- 229940081733 cetearyl alcohol Drugs 0.000 description 7
- 230000007794 irritation Effects 0.000 description 6
- OILXMJHPFNGGTO-ZAUYPBDWSA-N brassicasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@H](C)C(C)C)[C@@]1(C)CC2 OILXMJHPFNGGTO-ZAUYPBDWSA-N 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 4
- OILXMJHPFNGGTO-NRHJOKMGSA-N Brassicasterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@](C)([C@H]([C@@H](/C=C/[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 OILXMJHPFNGGTO-NRHJOKMGSA-N 0.000 description 4
- OILXMJHPFNGGTO-ZRUUVFCLSA-N UNPD197407 Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)C=C[C@H](C)C(C)C)[C@@]1(C)CC2 OILXMJHPFNGGTO-ZRUUVFCLSA-N 0.000 description 4
- 235000004420 brassicasterol Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 206010039792 Seborrhoea Diseases 0.000 description 3
- 235000011399 aloe vera Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 241001116389 Aloe Species 0.000 description 2
- 240000002791 Brassica napus Species 0.000 description 2
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 241001135871 Gentiana scabra Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 240000004534 Scutellaria baicalensis Species 0.000 description 2
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- BBTIMXAYZRWPNG-UHFFFAOYSA-N 3beta,Delta4-stigmasten-3-ol Natural products C1CC2=CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 BBTIMXAYZRWPNG-UHFFFAOYSA-N 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 240000001439 Opuntia Species 0.000 description 1
- 244000221569 Opuntia streptacantha Species 0.000 description 1
- 235000000771 Opuntia streptacantha Nutrition 0.000 description 1
- 241000908178 Tremella fuciformis Species 0.000 description 1
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 229940076810 beta sitosterol Drugs 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- QADVIPISOOQJMJ-WLKYTNTRSA-N beta-stigmasterol Natural products CCC(CC)C=C[C@@H](C)[C@H]1CC[C@@H]2[C@@H]1CC[C@H]3[C@H]2CC=C4C[C@@H](O)CC[C@]34C QADVIPISOOQJMJ-WLKYTNTRSA-N 0.000 description 1
- 235000000431 campesterol Nutrition 0.000 description 1
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940048864 ceramide 1 Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- HCXVJBMSMIARIN-UHFFFAOYSA-N stigmasterol Chemical compound C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 HCXVJBMSMIARIN-UHFFFAOYSA-N 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to an anti-allergy and soothing composition with a skin barrier repairing effect. The anti-allergy soothing composition with the skin barrier repairing effect can relieve and promote skin repairing and anti-inflammatory effects, the two anti-allergy components of the water-soluble component and the oil-soluble component act simultaneously, the skin barrier repairing is facilitated, the added three polysaccharides can also promote other effective components such as plant extracts, ceramide compounds and the like in the composition to exert the actual effects of the plant extracts, the ceramide compounds and the like, and the repairing effect is further enhanced.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to an anti-allergy and soothing composition with a skin barrier repairing effect.
Background
The skin barrier refers to a physical barrier, and the skin barrier can resist the stimulation of the skin by harmful substances in the outside world, and has moisturizing and anti-inflammatory effects to maintain the health and stability of the skin. However, with the pace of life of people increasing, the skin barrier of people is easily damaged due to the long-term face of electronic products with radiation and the immunity reduction caused by lack of exercise of people, and then the skin is easily allergic, dry and aged, and more serious people can suffer from a series of skin diseases, which affect the appearance and also affect the health of the body.
In the prior art, patent application document with an authorization publication number of CN104173207B discloses a skin barrier repair preparation and a preparation method thereof, and composite ceramide is added to compound specific grease, so that the stability of the product is improved, and the repair capability of the product on the skin barrier is also improved. However, the addition of ceramides may cause stinging of the allergic muscles.
Patent document with publication number CN105902476B discloses a moisturizing and repairing plant extract composition and its application in cosmetics, which promotes the formation of collagen in skin by compounding multiple plant extracts, deeply moisturizes water, and has certain repairing effect, but the plant extracts may cause the product to have poor weather resistance and short shelf life.
Therefore, there is a need for developing an anti-allergy soothing composition having skin barrier repairing effect, which has a certain anti-allergy soothing effect without irritation to the skin while having a good moisturizing and repairing effect, and which is excellent in stability and less prone to deterioration.
Disclosure of Invention
In order to solve the above problems, the present invention provides, in a first aspect, an anti-allergy soothing composition having a skin barrier repair effect, which is prepared from the following raw materials in percentage by weight: 2-60% of plant extract, 0.01-2% of ceramide compound, 0.01-1% of sterol, 3-20% of fatty alcohol, 0.5-10% of polysaccharide and water supplement to 100%.
Preferably, the anti-allergy soothing composition with skin barrier repair effect is prepared from the following raw materials in percentage by weight: 0.5-1% of sterol, 5-18% of fatty alcohol, 0.05-2% of ceramide, 1-8% of polysaccharide, 5-50% of plant extract and water supplement to 100%.
Preferably, the plant extract is one or more of perilla (perillabastyscreens (L.) Britt.) seed extract, scutellaria (scutellaria baica basilica georgi) root extract, centella asiatica (L.) Urban) extract, gentiana scabra Bunge root extract, oat (Avena sativa L.) extract, prickly pear cactus (OPUNTIA STREPTACANTHA) stem extract; further preferred are perilla seed extract, scutellaria root extract, centella asiatica extract and gentian root extract.
Preferably, the weight ratio of the perilla seed extract to the scutellaria root extract to the centella asiatica extract to the gentian root extract is (0.5-15): (0.5-15): (0.5-15): (0.5-15); further preferably, (1-10): (1-10): (1-10): (1-10); further, 1:1:1: 1.
The applicant has surprisingly found that the use of perilla seed extract, scutellaria root extract, centella asiatica extract and gentian root extract as plant extracts in compositions is particularly advantageous when the weight ratio is (0.5-15): (0.5-15): (0.5-15): (0.5-15), can reduce the irritation of the composition to the skin, and improve the repair ability of the anti-allergy and soothing composition. The composition of the perilla seed extract and the scutellaria root extract can absorb certain ultraviolet rays, eliminate free radicals, whiten and smooth skin and play a certain role in resisting senility and resisting wrinkles. The perilla seed extract and the centella asiatica extract can stimulate the ceaseless replacement of cells in the deep layer of the skin, accelerate metabolism and enable the skin to be firmer and smoother. However, the plant extract has poor stability although it has natural components.
Preferably, the ceramide compound is one or more of ceramide 1, ceramide 2, ceramide 3, ceramide 6II and ceramide E; further preferably, it is a mixture of ceramide 2, ceramide 3, ceramide 6II and ceramide E.
Preferably, the weight ratio of the ceramide 2, the ceramide 3, the ceramide 6II and the ceramide E is (0.001-1): (0.005-2): (0.001-1): (0.001-2): (0.002-1); further preferably, it is (0.05-0.8): (0.05-1.5): (0.05-0.8): (0.05-1.5): (0.08-0.8); further, the ratio is 1:2:1:2: 1.
In some preferred embodiments, in order to increase the self-protective function of the skin and prolong the skin protection time, the applicant selects the weight ratio of (0.001-1): (0.005-2): (0.001-1): (0.001-2): ceramide 2, ceramide 3, ceramide 6II, ceramide E of (0.002-1) are added to the composition as ceramide-type compounds. The synergistic effect of the ceramide 2, the ceramide 3 and the ceramide 6 can adjust the water-oil balance of the skin, maintain the water retention degree of the skin, promote the metabolism of cutin, help the renewal of a natural protective layer of the skin, and further strengthen the self-protection function of the skin, the addition of the ceramide 6II and the ceramide E can promote the synthesis of lipid, reduce wrinkles, promote the hydration of the epidermis, enhance the cohesion of epidermal cells, repair the barrier function of the skin, prolong the protection time of the composition on the skin, and play a role in skin barrier, thereby further improving the resistance of the skin and reducing the water loss through the skin. But people with sensitive skin may be intolerant to ceramides.
Preferably, the sterol is one or more of animal sterol, plant sterol and fungus sterol; more preferably, the plant sterol is phytosterol.
Preferably, the phytosterol is one or more of brassicasterol, campesterol, BETA-sitosterol and stigmasterol; more preferably, it is brassicasterol.
Preferably, the aliphatic alcohol is a linear alcohol having 12 to 22 carbon atoms.
Preferably, the fatty alcohol is one or more of lauryl alcohol, oleyl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol, isostearyl alcohol, and coconut oil alcohol; more preferably, stearyl alcohol, myristyl alcohol and cetearyl alcohol.
Preferably, the weight ratio of the stearyl alcohol, the myristyl alcohol and the cetearyl alcohol is (0.1-20): (0.2-10): (0.1-10); further preferably (5-15): (2-8): (1-5); further, it is 10:5: 3.
The applicant finds that the brassicasterol is selected as the sterol, and the mixing weight ratio is (0.1-20): (0.2-10): the stearyl alcohol, myristyl alcohol and cetearyl alcohol (0.1-10) can control oil and resist seborrhea, increase the stability of the composition and have certain moisture-keeping capacity, and the addition of myristyl alcohol and stearyl alcohol enables the composition to have certain flexibility and be not sticky, so that the use comfort of the composition is improved.
Preferably, the polysaccharide is a combination of one or more of Aloe vera (L.) Burm.) polysaccharide, β -glucan, tremella fuciformis berk polysaccharide, lycium barbarum (lycium chinense Miller) polysaccharide; further preferred is a mixture of aloe polysaccharides, beta-glucan and tremella polysaccharides.
Preferably, the weight ratio of the aloe polysaccharide to the beta-glucan to the tremella polysaccharide is (0.05-10): (0.1-10): (0.1-10); further preferably, (2-6): (3-8): (3-8); further, it is 4:5: 5.
The applicant has unexpectedly found that the weight ratio of (0.05-10): (0.1-10): (0.1-10) Aloe polysaccharide, beta-dextran and Tremella polysaccharide can be used as polysaccharide in composition for further improving anti-allergy and relieving effects of the composition. The reason for this is probably that although tremella polysaccharide can increase the moisture of the skin surface and has a certain effect of repairing the skin mucosa, the tremella polysaccharide has a single effect and a weak anti-allergic effect, and the applicant finds that the composition prepared by adding a certain amount of aloe polysaccharide and beta-glucan can improve the moisture of the skin surface, thereby achieving the effect of repairing the skin barrier and also having a certain anti-inflammatory and anti-allergic effect. In addition, the synergistic effect of the three polysaccharides can also promote other effective components in the composition, such as plant extracts, ceramide compounds and the like, to exert the actual effects of the plant extracts, the ceramide compounds and the like, so that the moisturizing, repairing and anti-allergy capabilities of the composition are stronger, and the physical and chemical properties are more excellent.
In addition, applicants have unexpectedly found that the addition of certain polysaccharides, sterols, and fatty alcohols in the present application reduces the irritation associated with ceramides, thereby making the resulting compositions suitable for use in the vast majority of the population, particularly those susceptible to allergy.
In a second aspect of the invention, there is provided a process for the preparation of an anti-allergy soothing composition having skin barrier repair comprising the steps of:
s1, mixing water, polysaccharide and plant extract according to weight percentage, and stirring uniformly at 35-55 ℃ to obtain a mixture A;
s2, mixing the ceramide compound, the sterol and the fatty alcohol according to the weight percentage, and stirring at 79-89 ℃ until the solution is uniform in texture to obtain a mixture B;
s3, cooling the mixture B to below 50 ℃, adding the mixture A, and stirring until the solution is uniform in texture.
Has the advantages that:
1. selecting the following components in percentage by weight (0.5-15): (0.5-15): (0.5-15): (0.5-15) Perilla seed extract, Scutellaria baicalensis root extract, centella asiatica extract, and Gentiana scabra root extract as plant extracts can improve the repair ability of the anti-allergy and soothing composition while reducing the irritation of the composition to the skin.
2. Selecting the following components in percentage by weight (0.001-1): (0.005-2): (0.001-1): (0.001-2): (0.002-1) ceramide 2, ceramide 3, ceramide 6II, and ceramide E can be added into the composition as ceramide compound, to improve self-protection function of skin and prolong skin protection time.
3. Rapeseed sterol is selected as sterol, and the compounding weight ratio is (0.1-20): (0.2-10): the stearyl alcohol, myristyl alcohol and cetearyl alcohol (0.1-10) can control oil and resist seborrhea, increase the stability of the composition, and have certain moisturizing capability.
4. Selecting the following components in percentage by weight (0.05-10): (0.1-10): (0.1-10) Aloe polysaccharide, beta-dextran and Tremella polysaccharide can be used as polysaccharide in composition for further improving anti-allergy and relieving effects of the composition.
5. The addition of specific sterols, fatty alcohols and polysaccharides in the present application can reduce the irritation of ceramides, making the prepared composition suitable for most people, especially people with allergies.
6. The anti-allergy soothing composition with the skin barrier repairing effect, prepared by the invention, can relieve and promote the skin repairing and anti-inflammatory effects, the two anti-allergy components, namely the water-soluble component (plant extract) and the oil-soluble component (sterol, fatty alcohol and ceramide), act simultaneously, the skin barrier repairing is facilitated, the added three polysaccharides can also promote the plant extract, the ceramide compound and other effective components in the composition to exert the actual effects of the plant extract, the ceramide compound and the like, and the repairing effect is further enhanced.
7. The anti-allergy soothing composition with the skin barrier repairing effect is suitable for various skins, such as sensitive skins, oily skins, dry skins and the like.
Detailed Description
Examples
Example 1
Example 1 provides an anti-allergy soothing composition with skin barrier repair, prepared from the following raw materials in weight percent: 40% of plant extract, 1% of ceramide compound, 0.5% of sterol, 15% of fatty alcohol, 5% of polysaccharide and 100% of supplementary water.
The plant extract is fructus Perillae extract, radix Scutellariae extract, herba Centellae extract and radix Gentianae extract.
The weight ratio of the perilla seed extract to the scutellaria root extract to the centella asiatica extract to the gentian root extract is 1:1:1: 1.
The perilla seed extract and the scutellaria root extract are purchased from green extract biotechnology limited of Foshan city.
The centella asiatica extract is purchased from Shanghai Jiajiaqiao Biotech Co., Ltd.
The gentian root extract was purchased from Guangdong Dimei New materials science and technology, Inc.
The ceramide compound is a mixture of ceramide 2, ceramide 3, ceramide 6II and ceramide E.
The ceramide compounds were all purchased from a japanese refinery.
The weight ratio of the ceramide 2 to the ceramide 3 to the ceramide 6II to the ceramide E is 1:2:1:2: 1.
The ceramide compounds were all purchased from a japanese refinery.
The sterol is plant sterol.
The phytosterol is rapeseed sterol.
The CAS number of the brassicasterol is 474-67-9.
The fatty alcohol is stearyl alcohol, myristyl alcohol and cetearyl alcohol.
The weight ratio of the stearyl alcohol, the myristyl alcohol and the cetearyl alcohol is 10:5: 3.
The CAS number for stearyl alcohol is 112-92-5.
The CAS number of the myristyl alcohol is 112-72-1.
The CAS number of the cetearyl alcohol is 67762-27-0.
The polysaccharide is a mixture of aloe polysaccharide, beta-glucan and tremella polysaccharide.
The weight ratio of the aloe polysaccharide to the beta-glucan to the tremella polysaccharide is 4:5: 5.
The aloe polysaccharides are purchased from Wanlv Bio-Inc. of Yunnan.
The beta-glucan was purchased from Shanghai Phyina Biotech, Inc.
The tremella polysaccharide was purchased from Shandong Furuida Biotech, Inc.
In a second aspect of the invention, there is provided a process for the preparation of an anti-allergy soothing composition having skin barrier repair comprising the steps of:
s1, mixing water, polysaccharide and plant extract according to weight percentage, and stirring uniformly at 45 ℃ to obtain a mixture A;
s2, mixing the ceramide compound, the sterol and the fatty alcohol according to the weight percentage, and stirring the mixture at 86 ℃ until the solution is uniform in texture to obtain a mixture B;
s3, cooling the mixture B to 45 ℃, adding the mixture A, and stirring until the solution is uniform in texture.
Example 2
Example 2 provides an anti-allergy soothing composition having skin barrier repair effect, and the specific embodiment is the same as example 1, except that: the ceramide compound is a mixture of ceramide 2, ceramide 3, ceramide 6 and ceramide E.
The weight ratio of the ceramide 2 to the ceramide 3 to the ceramide 6 to the ceramide E is 1:2:1: 1.
Example 3
Example 3 provides an anti-allergy soothing composition having skin barrier repair effect, which is specifically embodied in the same manner as in example 1, except that: the preparation raw materials comprise the following components in percentage by weight: 15% of fatty alcohol, 1% of ceramide compound, 5% of polysaccharide, 40% of plant extract and 100% of supplementary water.
Example 4
Example 4 provides an anti-allergy soothing composition having skin barrier repair effect, the specific embodiment being the same as example 1 except that: the polysaccharide is a mixture of aloe polysaccharide and tremella polysaccharide.
The weight ratio of the aloe polysaccharide to the tremella polysaccharide is 4: 5.
Example 5
Example 5 provides an anti-allergy soothing composition having skin barrier repair effect, the specific embodiment being the same as example 1 except that: the plant extracts are radix Scutellariae extract, herba Centellae extract, and radix Gentianae extract.
The weight ratio of the scutellaria baicalensis root extract to the centella asiatica extract to the gentian root extract is 1:1: 1.
Example 6
Example 6 provides an anti-allergy soothing composition having skin barrier repair effect, which is specifically embodied in the same manner as in example 1, except that: the ceramide compound is a mixture of ceramide 2, ceramide 3, ceramide 6 and ceramide 6 II.
The weight ratio of the ceramide 2 to the ceramide 3 to the ceramide 6II is 1:2:1: 2.
Performance test method
1. Weather resistance test
The anti-bradykinin compositions prepared in examples 1-6 were tested for stability and the results are reported in Table 1.
Heat resistance: keeping the anti-allergy relieving composition at 48 +/-2 ℃ for 24 hours, taking out the anti-allergy relieving composition, recovering the composition to room temperature, and comparing the appearance difference with that before the test;
cold resistance: after the anti-allergy relieving composition is placed at the temperature of minus 18 +/-2 ℃ and kept for 24 hours, the anti-allergy relieving composition is taken out and recovered to the room temperature, and the performance difference between the anti-allergy relieving composition and the performance difference before the test is compared;
high and low temperature cycle test: the anti-allergy relieving composition is placed at the temperature of 48 +/-2 ℃ for 1 hour, then is quickly taken out and is kept at the temperature of-18 +/-2 ℃ for 1 hour, is taken out after 12 times of circulation and is recovered to the room temperature, and the performance difference before the test is compared.
2. Test for transdermal Water loss
18 volunteers aged 20 to 50 years were selected and divided into three groups of six persons, and the skin barrier repair compositions prepared in examples 1 to 6 were used once in the morning and at night on the inner side of the arm, respectively, the transdermal water loss rates immediately after, after two weeks and after four weeks of use were measured, the transdermal water loss rate of the skin was measured using a transdermal water loss measuring instrument, 3 groups of average values were taken, and the change rate after four weeks (transdermal water loss rate after four weeks of use-transdermal water loss rate immediately after use)/transdermal water loss rate immediately after use: 100% was obtained by calculation, and the measured data were recorded in table 1.
3. Irritation test
Selecting 33 volunteers aged 25-55 years, applying samples to one side of the nasal wings and placebo to the other side of the nasal wings under the condition that the volunteers are not informed to apply the samples, applying lactic acid solution with the concentration of 2.5% to the nasal wings after the samples are naturally dried and absorbed for 60s, and allowing the volunteers to grade the stinging sensation of the nasal wings, wherein the effect is judged that the stinging sensation of the placebo side is obviously larger than that of the embodiment side, and the results are recorded in a table 1.
TABLE 1 physicochemical Properties
Claims (10)
1. An anti-allergy and soothing composition with skin barrier repair effect is characterized by comprising the following preparation raw materials in percentage by weight: 2-60% of plant extract, 0.01-2% of ceramide compound, 0.01-1% of sterol, 3-20% of fatty alcohol, 0.5-10% of polysaccharide and water supplement to 100%.
2. The anti-allergy soothing composition with skin barrier repair effect according to claim 1, which is prepared from the following raw materials in percentage by weight: 5-50% of plant extract, 0.05-2% of ceramide compound, 0.5-1% of sterol, 5-18% of fatty alcohol, 1-8% of polysaccharide and water supplement to 100%.
3. The anti-allergy soothing composition with skin barrier repair effect according to claim 1 or 2, wherein the sterol is one or more of animal sterol, plant sterol and fungus sterol.
4. An anti-allergy soothing composition with skin barrier repair effect as claimed in any one of claims 1 to 3 wherein said fatty alcohol is a linear alcohol having 12 to 22 carbon atoms.
5. The anti-allergy soothing composition with skin barrier repair effect according to claim 4, wherein the fatty alcohol is one or more of lauryl alcohol, oleyl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol, isostearyl alcohol, and coconut oil alcohol.
6. The anti-allergy soothing composition with skin barrier repair effect as claimed in claim 5, wherein said ceramide compound is a mixture of ceramide 2, ceramide 3, ceramide 6II, ceramide E.
7. The anti-allergy soothing composition with skin barrier repair effect according to any one of claims 1 to 6, wherein the polysaccharide is one or more of aloe polysaccharide, beta-glucan, tremella polysaccharide and lycium barbarum polysaccharide.
8. The anti-allergy soothing composition with skin barrier repair effect according to claim 7, wherein the plant extract is one or more of perilla seed extract, scutellaria root extract, centella asiatica extract, gentian root extract, oat extract, and opuntia ficus-indica stem extract.
9. The anti-allergy soothing composition with skin barrier repair effect according to claim 6, wherein the weight ratio of ceramide 2, ceramide 3, ceramide 6II and ceramide E is 0.001-1: 0.005-2: 0.001-1: 0.001-2: 0.002-1.
10. A process for the preparation of an anti-allergy soothing composition having skin barrier repair action according to any one of claims 1 to 9, comprising the steps of:
s1, mixing water, polysaccharide and plant extract according to weight percentage, and stirring evenly at 35-55 ℃ to obtain a mixture A;
s2, mixing the ceramide compound, the sterol and the fatty alcohol according to the weight percentage, and stirring at 79-89 ℃ until the solution is uniform in texture to obtain a mixture B;
s3, cooling the mixture B to below 50 ℃, adding the mixture A, and stirring until the solution is uniform in texture.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111067828A (en) * | 2019-12-16 | 2020-04-28 | 佛山市奥姿美生物科技有限公司 | Cosmetic composition for anti-allergy repair |
| CN112043668A (en) * | 2020-09-16 | 2020-12-08 | 上海百好博生物科技有限公司 | Composition with functions of moisturizing and repairing skin barrier and application |
| CN112641692A (en) * | 2020-12-31 | 2021-04-13 | 广州天玺生物科技有限公司 | Anti-allergy repairing composition and preparation method and application thereof |
| CN113244151A (en) * | 2021-05-31 | 2021-08-13 | 植然天成(北京)生物科技有限公司 | Soothing repair cream and preparation method thereof |
| CN113768830A (en) * | 2021-07-15 | 2021-12-10 | 广东正臣生物科技有限公司 | Skin care composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111067828A (en) * | 2019-12-16 | 2020-04-28 | 佛山市奥姿美生物科技有限公司 | Cosmetic composition for anti-allergy repair |
| CN112043668A (en) * | 2020-09-16 | 2020-12-08 | 上海百好博生物科技有限公司 | Composition with functions of moisturizing and repairing skin barrier and application |
| CN112641692A (en) * | 2020-12-31 | 2021-04-13 | 广州天玺生物科技有限公司 | Anti-allergy repairing composition and preparation method and application thereof |
| CN113244151A (en) * | 2021-05-31 | 2021-08-13 | 植然天成(北京)生物科技有限公司 | Soothing repair cream and preparation method thereof |
| CN113768830A (en) * | 2021-07-15 | 2021-12-10 | 广东正臣生物科技有限公司 | Skin care composition and preparation method thereof |
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