CN112043668A - Composition with functions of moisturizing and repairing skin barrier and application - Google Patents

Composition with functions of moisturizing and repairing skin barrier and application Download PDF

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Publication number
CN112043668A
CN112043668A CN202010974005.XA CN202010974005A CN112043668A CN 112043668 A CN112043668 A CN 112043668A CN 202010974005 A CN202010974005 A CN 202010974005A CN 112043668 A CN112043668 A CN 112043668A
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Prior art keywords
composition
skin
moisturizing
skin barrier
water
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Chinese (zh)
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袁清标
袁博
戴晶
杨璇
赵磊
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Shanghai Baihaobo Biotechnology Co ltd
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Shanghai Baihaobo Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

The invention relates to a composition for moisturizing and repairing skin barrier function, which is characterized by comprising the following raw materials in percentage by weight: 0.1-0.5% of sour bean seed polysaccharide; 0.5-3% of water, butanediol and artemisia princeps leaf extract; 1-5% of composition of ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, water, methylparaben and propylparaben; 1-5% of a composition of water, 1, 3-propanediol, lactobacillus fermentation lysate and cosmetic basic ingredients. The invention has the beneficial effects that: the composition for repairing the skin barrier can achieve the effects of reducing the transdermal water loss rate of the skin, improving the smoothness of the skin, improving the scale state of the skin, relieving skin itch and the like from various ways. Meanwhile, the composition has short production period and simple prescription, and is suitable for various cosmetic products.

Description

Composition with functions of moisturizing and repairing skin barrier and application
Technical Field
The invention relates to the technical field of compositions, in particular to a composition with functions of moisturizing and repairing skin barriers and application thereof.
Background
With the social progress and the improvement of living standard, the beauty and skin care become a part of the daily life of people. Because people who are sensitive to environmental pollution, excessive use of various cosmetics and excessive skin cleaning are more and more, one of the main manifestations of sensitivity is the reduction of the barrier function of the skin. The main manifestations are that the hydration degree of horny layer is low, complete sebum membrane can not be formed, skin is easy to dry and scurf, and the effect is especially prominent in autumn and winter and old skin.
The humectant can mimic the improvement of epidermal function and repair of epidermal barrier function when the skin barrier is disrupted and the water content of the stratum corneum is reduced, and the components of the humectant are distributed in the intercellular sites at the upper part of the epidermis layer, and the cong is a diffuse hydrophobic phase to rapidly reduce water loss. Moisturizing is a key basis of skin function, and the reduction of the skin moisturizing function can cause the reduction of the skin barrier function, whereas the damage of the skin barrier function can cause the accelerated loss of skin moisture, so that dry, rough and wrinkled skin problems are generated. The lack of water in the skin can affect cell metabolism and information transmission, increase susceptibility rate of dermatosis, and induce eczema, acne, etc.
Chinese patent 201610216262.0, a composition for repairing skin barrier, discloses a composition of trehalose and sodium hyaluronate for cosmetics, and only shows that the composition has the effects of relieving and treating symptoms of red swelling, hot pain, molting, pruritus and the like caused by skin after beauty means such as laser beauty treatment, fruit acid skin change and the like, and moisturizing. The effects of multiple factors on skin barrier repair, such as the supplementation of the important constituent intercellular lipids of the skin barrier, are not considered. The traditional polysaccharide humectant is generally limited to the moisture content of the skin, but neglects the repair of the skin barrier function, only plays a role in relieving, and cannot solve the problem of skin water shortage from the source. Therefore, multiple factors related to the skin barrier function should be considered, and a multi-functional active substance combination is matched to achieve the final purposes of maintaining and improving the skin moisture, nourishing the skin and improving the health state of the stratum corneum.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a composition for moisturizing and repairing skin barriers.
The invention is realized by the following technical scheme:
designing a composition for moisturizing and repairing skin barrier function, which is characterized by comprising the following raw materials in percentage by weight:
Figure BDA0002685095820000021
preferably, the composition of the water, the butanediol and the artemisia inflata kom leaf extract comprises the following raw materials in percentage by weight:
68.5 to 69.2 percent of water
Butanediol of 30 percent
0.8-1.5% of artemisia inflata extract.
Preferably, the ceramide composition comprises the following raw materials in percentage by weight:
Figure BDA0002685095820000022
Figure BDA0002685095820000031
preferably, the ceramide composition comprises the following raw materials in percentage by weight:
Figure BDA0002685095820000032
Figure BDA0002685095820000041
preferably, the composition of water, 1, 3-propanediol, lactobacillus fermentation lysate comprises the following raw materials in weight percent:
46.5 to 47.5 percent of water
46.5-47.5% of 1, 3-propylene glycol
5-7% of lactobacillus fermentation lysate.
Preferably, the molecular weight of the tamarind seed polysaccharide is 40-50 ten thousand.
Preferably, the cosmetic base is a carrier for cosmetic formulations such as water, lotion, cream, etc.
The use of the composition for moisturizing and repairing skin barrier function is characterized in that: the composition is used for preparing a skin care product, and the composition is used in the skin care product, so that the skin care product has the functions of moisturizing and repairing skin barrier.
The invention has the beneficial effects that: the composition for repairing the skin barrier can achieve the effects of reducing the transdermal water loss rate of the skin, improving the smoothness of the skin, improving the scale state of the skin, relieving skin itch and the like from various ways. Meanwhile, the composition has short production period and simple prescription, and is suitable for various cosmetic products.
Drawings
FIG. 1 is a graph of the 14-day variation of the TEWL test.
FIG. 2 is a graph of the 14 day change/D0 value for the TEWL test.
FIG. 3 is a graph of the SESC test 14 day change/D0 value.
FIG. 4 is a graph of the SESC test 14 day change value/D0 value.
In the figure: sample a is a blank emulsion without the addition of the active of this patent; sample B is an emulsion to which the active composition of this patent is added.
Detailed Description
The following further describes the embodiments of the present invention.
The invention provides a composition for moisturizing and repairing skin barrier function, which comprises the following core components in part by weight: is prepared by matching the following raw materials (trade names) according to the weight percentage: XILOGEL HS 0.1-0.5%; 0.5-3% of NEWAPLE; 1-5% of SK-INFLUX; 1-5% of biotilys (NAT) and 97.4-86.5% of basic ingredients of the cosmetic.
Introduction of raw materials:
XILOGEL HS: tamarind seed polysaccharide, which forms a viscous colloid having a unique skin feel and simultaneously can exert a moisturizing effect equivalent to hyaluronic acid due to its branched structure.
NEWAPLE: water, butanediol and artemisia princeps leaf extract, and has excellent anti-allergic and anti-inflammatory effects.
SK-INVLUX: ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, water, methylparaben and propylparaben, and the SK-INFLUX is a concentrated lipid similar to the intercellular substance in the brick mud structure of the epidermal layer of the skin, and can quickly supplement lost intercellular substance and repair the barrier function of the skin. Preferably, the composition of ceramide 3, ceramide 6II, ceramide 1, phytosphingosine, cholesterol, sodium lauroyl lactylate, carbomer, xanthan gum, water, methylparaben and propylparaben.
BIOTILYS (NAT) is water, 1, 3-propanediol, lactobacillus fermentation lysate, BIOTILYS (NAT is lactobacillus fermentation lysate, is a comprehensive protection factor with short-acting and long-acting functions, can increase the diversity of skin symbiotic microorganisms, maintain the integrity of skin barrier and maintain the balance state required by healthy skin.
The cosmetic base component refers to carriers of cosmetic dosage forms such as water, lotion, cream, etc.
The technical solutions of the present invention are further described below with reference to examples, which are believed to be clear to those skilled in the art.
Example one
The composition for moisturizing and repairing the skin barrier function is characterized by comprising the following raw materials in percentage by weight: weighing the raw materials in proportion, sequentially adding the components into a reaction kettle, mixing and stirring uniformly to obtain the composition with the functions of moisturizing and repairing skin barriers.
Figure BDA0002685095820000061
Figure BDA0002685095820000071
Example two
The composition for moisturizing and repairing the skin barrier function is characterized by comprising the following raw materials in percentage by weight: weighing the raw materials in proportion, sequentially adding the components into a reaction kettle, mixing and stirring uniformly to obtain the composition with the functions of moisturizing and repairing skin barriers.
Figure BDA0002685095820000072
Figure BDA0002685095820000081
EXAMPLE III
The composition for moisturizing and repairing the skin barrier function is characterized by comprising the following raw materials in percentage by weight: weighing the raw materials in proportion, sequentially adding the components into a reaction kettle, mixing and stirring uniformly to obtain the composition with the functions of moisturizing and repairing skin barriers.
Figure BDA0002685095820000082
Figure BDA0002685095820000091
Example four
The composition for moisturizing and repairing the skin barrier function is characterized by comprising the following raw materials in percentage by weight: weighing the raw materials in proportion, sequentially adding the components into a reaction kettle, mixing and stirring uniformly to obtain the composition with the functions of moisturizing and repairing skin barriers.
Figure BDA0002685095820000092
Figure BDA0002685095820000101
The moisturizing and skin barrier repair function of the moisturizing and skin barrier repair functional composition is evaluated by two sets of test data of TEWL and SESC. Wherein sample a is a blank emulsion without the addition of the active of this patent; sample B is an emulsion to which the active composition of this patent is added.
Figure BDA0002685095820000102
Figure BDA0002685095820000111
Figure BDA0002685095820000112

Claims (9)

1. The composition for moisturizing and repairing the skin barrier function is characterized by comprising the following raw materials in percentage by weight:
Figure FDA0002685095810000011
2. the composition for moisturizing and repairing skin barrier function according to claim 1, comprising the following raw materials in percentage by weight:
Figure FDA0002685095810000012
3. the composition for moisturizing and repairing skin barrier function according to claim 1 or 2, wherein the composition of water, butanediol and Artemisia princeps comprises the following raw materials in percentage by weight:
68.5 to 69.2 percent of water
Butanediol of 30 percent
0.8-1.5% of artemisia inflata extract.
4. The composition for moisturizing and repairing skin barrier function according to claim 1 or 2, wherein the ceramide composition comprises the following raw materials in percentage by weight:
Figure FDA0002685095810000021
5. a moisturizing and skin barrier repair composition according to claim 1 or 2, wherein: the ceramide composition comprises the following raw materials in percentage by weight:
Figure FDA0002685095810000022
Figure FDA0002685095810000031
6. a moisturizing and skin barrier repair composition according to claim 1 or 2, wherein: the composition of water, 1, 3-propanediol, lactobacillus fermentation lysate comprises the following raw materials in weight percent:
46.5 to 47.5 percent of water
46.5-47.5% of 1, 3-propylene glycol
5-7% of lactobacillus fermentation lysate.
7. A moisturizing and skin barrier repair composition according to claim 1 or 2, wherein: the molecular weight of the tamarind seed polysaccharide is 40-50 ten thousand.
8. A moisturizing and skin barrier repair composition according to claim 1 or 2, wherein: the cosmetic base component refers to carriers of cosmetic dosage forms such as water, lotion, cream, etc.
9. Use of the moisturizing and skin barrier function repairing composition according to claim 1, wherein: the composition is used for preparing a skin care product, and the composition is used in the skin care product, so that the skin care product has the functions of moisturizing and repairing skin barrier.
CN202010974005.XA 2020-09-16 2020-09-16 Composition with functions of moisturizing and repairing skin barrier and application Pending CN112043668A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112957309A (en) * 2021-03-02 2021-06-15 上海赛儿生物科技有限公司 Composition for rapidly improving sensitive muscle and barrier damage and preparation method and application thereof
CN113133953A (en) * 2021-04-26 2021-07-20 上海赛儿生物科技有限公司 Composition for quickly relieving, moisturizing, strengthening and sensitive skin and preparation method and application thereof
CN113768830A (en) * 2021-07-15 2021-12-10 广东正臣生物科技有限公司 Skin care composition and preparation method thereof
CN114983886A (en) * 2022-05-27 2022-09-02 广东嘉丹婷日用品有限公司 Anti-allergy soothing composition with skin barrier repair effect
CN115670986A (en) * 2022-09-07 2023-02-03 广东丸美生物技术股份有限公司 Composition with effects of preventing external irritation and strengthening skin barrier, moisturizing cream and preparation method thereof

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CN110755321A (en) * 2019-11-15 2020-02-07 上海百好博化工有限公司 Composition for quick allergy relief and preparation method and application thereof
CN110897941A (en) * 2019-12-12 2020-03-24 广州艾蓓生物科技有限公司 Moisturizing and repairing composition with quicksand effect and preparation method thereof

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CN110464700A (en) * 2019-09-20 2019-11-19 简肌方式日用化妆品(广州)有限公司 A kind of Triple barrier reparation molecular combinations method
CN110755321A (en) * 2019-11-15 2020-02-07 上海百好博化工有限公司 Composition for quick allergy relief and preparation method and application thereof
CN110897941A (en) * 2019-12-12 2020-03-24 广州艾蓓生物科技有限公司 Moisturizing and repairing composition with quicksand effect and preparation method thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112957309A (en) * 2021-03-02 2021-06-15 上海赛儿生物科技有限公司 Composition for rapidly improving sensitive muscle and barrier damage and preparation method and application thereof
CN113133953A (en) * 2021-04-26 2021-07-20 上海赛儿生物科技有限公司 Composition for quickly relieving, moisturizing, strengthening and sensitive skin and preparation method and application thereof
CN113768830A (en) * 2021-07-15 2021-12-10 广东正臣生物科技有限公司 Skin care composition and preparation method thereof
CN114983886A (en) * 2022-05-27 2022-09-02 广东嘉丹婷日用品有限公司 Anti-allergy soothing composition with skin barrier repair effect
CN114983886B (en) * 2022-05-27 2024-04-19 广东嘉丹婷日用品有限公司 Anti-allergic and soothing composition with skin barrier repair effect
CN115670986A (en) * 2022-09-07 2023-02-03 广东丸美生物技术股份有限公司 Composition with effects of preventing external irritation and strengthening skin barrier, moisturizing cream and preparation method thereof

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Application publication date: 20201208