CN111494299B - Ceramide compound muscle-calming repair factor and emulsion thereof - Google Patents
Ceramide compound muscle-calming repair factor and emulsion thereof Download PDFInfo
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Abstract
The invention discloses a ceramide compound anmei repairing factor and emulsion thereof; aims to provide a repair factor which has no stimulation to skin, can effectively relieve damaged skin, adjust a skin water-oil balance system and effectively repair a damaged skin barrier, and an emulsion which has strong permeability, effectively repairs the skin barrier and protects external stimulation; the repair factors include the following: 112-19 parts of ceramide, 8-11 parts of seaweed extract, 5-7 parts of coix seed extract, 4-6 parts of centella asiatica extract, 3-6 parts of wrinkled gianthyssop extract, 3-6 parts of scutellaria baicalensis root extract, 2-4 parts of common andrographis herb extract, 1-2 parts of compound fermentation liquid and 1-2 parts of tea seed oil; belongs to the field of cosmetics.
Description
Technical Field
The invention relates to a muscle-calming repair factor, and also relates to an emulsion containing the muscle-calming repair factor, belonging to the technical field of cosmetics.
Background
The physical barrier of skin is composed of a sebum membrane, keratin, lipid, a sandwich structure, a brick wall structure, mucopolysaccharide in dermis, mucopolysaccharide and the like, has the functions of resisting external harm, irritants and ultraviolet rays, and also has the functions of moisturizing, regulating inflammation and resisting aging.
However, due to the increasingly serious environmental pollution, ultraviolet irradiation, closed air-conditioning environment, poor living habits, especially poor skin care habits, such as skin barrier damage caused by long-term use of cosmetics containing hormones, lead and mercury and a large amount of essence and preservative, skin dryness, skin dullness, coarse pores, skin roughness, accelerated skin aging, thinned cuticle, skin sensitivity such as red, molting and stabbing pain, pigmentation atopic dermatitis, eczema, psoriasis, ichthyosis, solar dermatitis and the like, skin greasiness such as irritant dermatitis, hormone-dependent dermatitis and the like, seborrheic diseases such as acne, rosacea and seborrheic dermatitis, the life of people is seriously influenced.
At present, although the skin-protecting repair products on the market look full of Linglan, the products are also mixed with fish and dragon, and few products can repair the affected skin from the root and care the damaged skin cells.
Disclosure of Invention
In view of the above problems, a first object of the present invention is to provide a repairing factor which is non-irritating to skin, and can effectively soothe damaged skin, regulate the water and oil balance system of skin, and effectively repair the damaged skin barrier.
It is a second object of the present invention to provide an emulsion which is highly permeable and effective in repairing the skin barrier and protecting against external irritations.
In order to solve the above technical problems, a first technical solution provided by the present invention is as follows:
a ceramide compound muscle-calming repair factor comprises the following components in parts by weight: 112-19 parts of ceramide, 8-11 parts of seaweed extract, 5-7 parts of coix seed extract, 4-6 parts of centella asiatica extract, 3-6 parts of wrinkled gianthyssop extract, 3-6 parts of scutellaria baicalensis root extract, 2-4 parts of andrographis paniculata extract, 1-2 parts of compound fermentation liquid and 1-2 parts of tea seed oil.
Further preferably, the ceramide compound skin-soothing repair factor also comprises 1-3 parts of shea butter extract, 1-2 parts of calendula oil and 1-1.2 parts of Gnaphalium affine flower oil.
Further preferably, the ceramide compound skin-soothing repair factor further comprises 2-4 parts of a suspected myrtle seed extract and 1-2 parts of a mung bean seed extract.
Preferably, the compound ceramide compound anmei repairing factor is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate, and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 2-4:1-3: 1-3.
Further preferably, the ceramide compound muscle-soothing repair factor is prepared from the following components in parts by weight: 112-19 parts of ceramide, 8-11 parts of seaweed extract, 5-7 parts of coix seed extract, 4-6 parts of centella extract, 3-6 parts of wrinkled gianthyssop extract, 3-6 parts of scutellaria root extract, 2-4 parts of common andrographis herb extract, 1-3 parts of camellia leaf extract fermentation product, 1-2 parts of tea seed oil and 1-3 parts of shea butter extract; 1-2 parts of calendula oil; 1-1.2 parts of Gnaphalium affine flower oil, 2-4 parts of Bixiong peach seed extract and 1-2 parts of mung bean seed extract.
Still more preferably, the above-mentioned ceramide compound anmei repairing factor is prepared by the following steps:
(1) cleaning seaweed, sterilizing by ultraviolet, and pulverizing;
(2) adding 70% ethanol 2-5 times the volume of Sargassum into Sargassum, adjusting pH to alkaline, and pulping;
(3) adding complex enzyme with the amount of 1-3% of the seaweed mass into the seaweed slurry, carrying out enzymolysis at 30-40 ℃ for 12-24 hours, then carrying out enzyme deactivation after the enzymolysis is finished, filtering to obtain precipitate and filtrate, and then filtering and collecting crude filtrate;
(4) adding chitosan solution into the filtrate, stirring, filtering with a filter membrane, and collecting the fine filtrate;
(5) and (4) concentrating the fine filtrate obtained in the step (4) to obtain a seaweed extract.
The compound enzyme is a mixture of glucoamylase, isoamylase, superoxide dismutase and cellulase.
The second technical scheme provided by the invention is as follows:
an emulsion containing ceramide compound anmei repairing factor is prepared from 1-5% of ceramide compound anmei repairing factor and 5-99% of matrix, wherein the total mass of the emulsion is 100%.
Further, the emulsion containing the ceramide compound anmei repairing factor comprises the following components in percentage by mass based on 100% of the total mass of the matrix: 0.8-1.5% of C12-20 alkyl glucoside, 0.1-1% of sorbitan stearate and 0.1-1.2% of hydrogenated lecithin; 0.1-1% of cyclotetrasiloxane, 0.1-1% of dimethiconol, 0.5-2% of phytosterol oleate, 1-3% of cetearyl alcohol, 1-3% of tetrahydro-methyl pyrimidine carboxylic acid, 0.02-0.1% of disodium EDTA, 3-6% of glycerol and 2-5% of squalane; 0.3-1% of poly-gamma-sodium glutamate, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.5-2% of plant preservative and the balance of deionized water.
Further, in the emulsion containing the ceramide compound anmei repairing factor, the plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia officinalis flower extract and a zanthoxylum fruit extract according to the mass ratio: 2-5:2-5:1-3: 1-2.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
1. the technical scheme provided by the invention is characterized in that ceramide 1, a seaweed extract, a coix seed extract, a centella asiatica extract, a wrinkled gianthyssop extract, a scutellaria baicalensis root extract, an andrographis paniculata extract, a compound fermentation liquid and tea seed oil are scientifically compounded and synergized. Because the content of ceramide naturally exists in the skin and reaches as high as 40-50 percent, the technical scheme takes the ceramide as a main component, adheres to keratinocytes, supplements the moisture of the skin, and is combined with the components of alginic acid, crude protein, various vitamins, enzymes and trace elements in the seaweed extract, and the coix seed extract fatty acid, lipid, carbohydrate, sterol, alkaloid, triterpenes and the like; asiaticoside, madecassoside, asiatic acid and madecassic acid in centella asiatica extract; flavonoids in agastache rugosa; baicalin and baicalein in the extract of Scutellariae radix contain various lactones and flavones. The andrographis herb extract contains andrographolide, phenolic substances such as methoxyflavonoids, sterol saponins, saccharides and condensed tannins, fermentation liquor, fatty acids in tea seed oil are compounded with each other, collagen and cell layer fibronectin are improved, the epidermis and dermis connecting part is tightened, cell migration, adhesion, proliferation, hemostasis and skin tissue repair are promoted, the epidermis barrier capability is improved, skin moisture is enhanced, the skin becomes softer, the problem of skin relaxation is effectively solved, the formation of collagen in the dermis layer is promoted, damaged tissues are healed, the skin is tightened, and accordingly the skin effects of antibiosis, inflammation diminishing, antianaphylaxis and sedation are achieved.
2. The aspergillus/yeast/barley fermentation product extract filtrate, the leuconostoc/radish root fermentation product filtrate and the lactobacillus/rye fine powder fermentation product filtrate in the composite fermentation liquid can further soften cutin, promote the repair and reconstruction of skin cuticle, accelerate the differentiation of keratinocytes, promote the absorption of nutrient components, and can effectively resist bacteria, inflammation and corrosion.
3. According to the technical scheme provided by the invention, the oleanolia resin extract, the aspergillus niger flower oil and the allelopathia odorata seed extract are compounded, various trace elements required by the skin are supplemented, the effects of moisturizing and moisturizing are further increased, the water loss of the skin can be prevented, the defense capacity of the skin is increased, the damaged skin is calmed, the inflammation is effectively prevented, the oxidation is resisted, the skin quality is conditioned, and the skin regeneration is promoted, so that the effects of repairing the natural sebum membrane of the skin, strengthening the discharging capacity of the skin surface barrier and repairing the skin barrier are achieved.
4, the technology provided by the invention adopts an enzyme extraction method for the seaweed extract, effectively retains seaweed polysaccharide, vitamins, alginic acid, crude protein, multiple vitamins, enzymes, trace elements and the like in the seaweed, regulates the water-oil balance of skin, promotes the blood circulation of the skin and enhances the surface skin hematopoiesis function.
5, each component of the matrix provided by the technical scheme is strictly screened and optimized, and double stimulation and damage to damaged skin are reduced.
6, the technical scheme provided by the invention adopts the plant preservative, and has the combined action with the staphylococcus aureus/radish root fermentation product filtrate and the calendula oil in the emulsion, so that the emulsion has the inhibition effect on gram-negative bacteria such as enterobacteria and the like, and various gram-positive bacteria and fungi such as staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, candida albicans, bacillus subtilis, streptococcus and the like, reduces the damage to human skin cells to the minimum, has no irritation or allergic reaction, and has biodegradability.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following embodiments, but the present invention is not limited thereto, and any limited number of modifications made by anyone within the scope of the present invention are still within the scope of the present invention.
It should be noted that the raw materials used in the technical scheme provided by the present invention, except for the specific description, are prepared by conventional means or purchased through commercial channels.
Example 1
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: 119 parts of ceramide, 11 parts of seaweed extract, 7 parts of coix seed extract, 6 parts of centella asiatica extract, 3 parts of wrinkled gianthyssop extract, 6 parts of scutellaria baicalensis root extract, 2 parts of common andrographis herb extract, 2 parts of compound fermentation liquid and 1 part of tea seed oil.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 2:3: 1.
Example 2
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: 117 parts of ceramide, 9 parts of seaweed extract, 5 parts of coix seed extract, 4 parts of centella asiatica extract, 6 parts of wrinkled gianthyssop extract, 3 parts of scutellaria baicalensis root extract, 4 parts of common andrographis herb extract, 1 part of compound fermentation liquid and 2 parts of tea seed oil.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 4:2: 2.
Example 3
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: 112 parts of ceramide, 8 parts of seaweed extract, 6 parts of coix seed extract, 5 parts of centella asiatica extract, 4 parts of wrinkled gianthyssop extract, 4 parts of scutellaria baicalensis root extract, 3 parts of common andrographis herb extract, 1.5 parts of compound fermentation liquid and 1.5 parts of tea seed oil.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 4:3: 1.
Example 4
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: the traditional Chinese medicine composition comprises, by weight, 115 parts of ceramide, 10 parts of seaweed extract, 6 parts of coix seed extract, 6 parts of centella asiatica extract, 4 parts of wrinkled gianthyssop extract, 5 parts of scutellaria baicalensis root extract, 3 parts of common andrographis herb extract, 2 parts of composite fermentation liquid, 1 part of tea seed oil, 2 parts of shea butter extract, 1.5 parts of calendula officinalis flower oil and 1 part of Gnaphalium affine flower oil.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 2:2: 2.
Example 5
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: 113 parts of ceramide, 10 parts of seaweed extract, 6 parts of coix seed extract, 5 parts of centella asiatica extract, 5 parts of wrinkled gianthyssop extract, 5 parts of scutellaria baicalensis root extract, 2.5 parts of common andrographis herb extract, 1.5 parts of compound fermentation liquid, 1.5 parts of tea seed oil, 1.5 parts of shea butter fruit resin extract, 1 part of calendula oil and 1.2 parts of Gnaphalium affine flower oil.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 3:2: 3.
Example 6
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: the traditional Chinese medicine composition comprises the following components, by weight, 116 parts of ceramide, 10 parts of seaweed extract, 5.5 parts of coix seed extract, 4.5 parts of centella asiatica extract, 3.5 parts of wrinkled gianthyssop extract, 4.5 parts of scutellaria baicalensis root extract, 2.5 parts of andrographis paniculata extract, 1.2 parts of compound fermentation liquor, 1.2 parts of tea seed oil, 1.5 parts of shea butter extract, 2 parts of calendula flower oil, 1 part of Gnaphalium affine flower oil, 4 parts of allelopanax pictus seed extract and 1 part of mung bean seed extract.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 2:1: 1.
Example 7
The invention provides a ceramide compound muscle-calming repair factor which comprises the following components in parts by weight: 118 parts of ceramide, 9 parts of seaweed extract, 5.5 parts of coix seed extract, 4.5 parts of centella asiatica extract, 4.5 parts of wrinkled gianthyssop extract, 5.5 parts of scutellaria baicalensis root extract, 2.5 parts of common andrographis herb extract, 1.5 parts of compound fermentation liquid, 1.5 parts of tea seed oil, 2 parts of shea butter fruit resin extract, 1.5 parts of calendula officinalis flower oil, 1 part of Gnaphalium affine flower oil, 2.5 parts of Bidens obovata seed extract and 1.5 parts of mung bean seed extract.
The composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 4:1: 1.
The seaweed extracts described in examples 1 to 7 were prepared by the following steps:
(1) cleaning Sargassum (preferably red algae), sterilizing with ultraviolet, pulverizing, and sieving with 30 mesh sieve;
(2) adding 70% ethanol 2-5 (preferably 3) times the volume of Sargassum into Sargassum, adjusting pH to 7.5, and grinding into slurry;
(3) adding complex enzyme 1-3% (preferably 2%) of Sargassum into Sargassum slurry, performing enzymolysis at 30-40 deg.C for 12-24 hr (at 30 deg.C for 24 hr or at 40 deg.C for 12 hr, preferably at 32 deg.C for 20 hr), inactivating enzyme after enzymolysis, filtering to obtain precipitate and filtrate, and filtering to collect crude filtrate.
(4) Adding 2% of chitosan into the filtrate, stirring, filtering with a filter membrane (0.5um), and collecting the fine filtrate;
(5) and (4) carrying out reduced pressure concentration on the fine filtrate in the step (4) for 0.8g/mL to obtain the seaweed extract.
The compound enzyme is prepared from glucoamylase, isoamylase, superoxide dismutase and cellulase according to the mass ratio: 2:2:1: 3.
Example 8
The invention provides an emulsion containing ceramide compound anmei repairing factor, which comprises 2% of ceramide compound anmei repairing factor provided by example 1, 1.4% of C12-20 alkyl glucoside, 0.1% of sorbitan stearate and 1.1% of hydrogenated lecithin, wherein the total mass of the emulsion is 100%; 0.1% of cyclotetrasiloxane, 0.6% of dimethiconol, 1% of phytosterol oleate, 2% of cetearyl alcohol, 2% of tetrahydro-methyl pyrimidine carboxylic acid, 0.05% of disodium EDTA, 2% of glycerol and 3% of squalane; 0.5% of poly-gamma-sodium glutamate, 0.4% of allantoin, 0.6% of tocopherol acetate, 1% of plant preservative and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 2:5:1: 1.
Example 9
The invention provides an emulsion containing ceramide compound anmei repairing factor, which comprises 2% of ceramide compound anmei repairing factor provided by example 4, 0.9% of C12-20 alkyl glucoside, 0.2% of sorbitan stearate and 1.0% of hydrogenated lecithin, wherein the total mass of the emulsion is 100%; 0.7% of cyclotetrasiloxane, 0.5% of dimethiconol, 0.6% of phytosterol oleate, 2.9% of cetearyl alcohol, 1.2% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.07% of disodium EDTA, 3-6% of glycerol and 4.8% of squalane; 0.32% of poly-gamma-sodium glutamate, 0.48% of allantoin, 0.5% of tocopherol acetate, 1.5% of plant preservative and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 5:5:1: 2.
Example 10
The invention provides an emulsion containing ceramide compound anmei repairing factor, which comprises 2% of ceramide compound anmei repairing factor provided by example 5, 1.4% of C12-20 alkyl glucoside, 0.6% of sorbitan stearate and 0.9% of hydrogenated lecithin, wherein the total mass of the emulsion is 100%; 0.5% of cyclotetrasiloxane, 0.6% of dimethiconol, 1.6% of phytosterol oleate, 1.4% of cetearyl alcohol, 1.2% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.06% of disodium EDTA, 2.4% of glycerol and 2.6% of squalane; 0.6% of poly-gamma-sodium glutamate, 0.4% of allantoin, 0.3% of tocopherol acetate, 1.2% of plant preservative and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 5:5:1: 1.
Example 11
The invention provides an emulsion containing ceramide compound anmei repairing factor, which comprises 2% of ceramide compound anmei repairing factor provided by example 6, 0.85% of C12-20 alkyl glucoside, 0.2% of sorbitan stearate and 0.2% of hydrogenated lecithin, wherein the total mass of the emulsion is 100%; 0.7% of cyclotetrasiloxane, 0.6% of dimethiconol, 1.4% of phytosterol oleate, 1.6% of cetearyl alcohol, 2.2% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.07% of disodium EDTA, 4% of glycerol and 2.5% of squalane; 0.5% of poly-gamma-sodium glutamate, 0.3% of allantoin, 0.3% of tocopherol acetate, 1.5% of plant preservative and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 5:5:3: 2.
Example 12
The invention provides an emulsion containing ceramide compound anmei repairing factor, which comprises 2% of ceramide compound anmei repairing factor provided by example 7, 1.2% of C12-20 alkyl glucoside, 0.5% of sorbitan stearate and 0.5% of hydrogenated lecithin, wherein the total mass of the emulsion is 100%; 0.5% of cyclotetrasiloxane, 0.5% of dimethiconol, 1.5% of phytosterol oleate, 1.5% of cetearyl alcohol, 1.5% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.05% of disodium EDTA, 4% of glycerol and 4% of squalane; 0.5% of poly-gamma-sodium glutamate, 0.25% of allantoin, 0.4% of tocopherol acetate, 1% of plant preservative and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 2:3:3: 2.
The ceramide polypeptide compound anmei emulsion described in example 8-example 12 was prepared according to conventional techniques in the art.
In order to better prove the advantages of the technical scheme provided by the application, some experimental examples in the development process of the application are given as comparative examples.
Comparative example 1
The same components and contents as those of the ceramide compound anmei repairing factor in example 7, except that the same amount of seaweed extract was used instead of ceramide 1.
Comparative example 2
The same components and contents as those of the ceramide compound anmei repairing factor in example 7, except that the same amount of seaweed extract was used instead of the coix seed extract.
Comparative example 3
The same components and contents as those of the ceramide compound anmei repairing factor in example 7, except that the same amount of seaweed extract was used instead of centella asiatica extract.
Comparative example 4
The same components and contents as those of the ceramide compound anmei repairing factor in example 7, except that the same amount of seaweed extract was used instead of tea seed oil.
Comparative example 5
The same components and contents as those of the ceramide compound anmei repairing factor in example 7, except that the same amount of seaweed extract is used to replace the compound fermentation broth.
Comparative example 6
The same components and contents as those of the ceramide compound anmei repairing factor in example 7, except that the same amount of scutellaria root extract is used instead of andrographis paniculata extract.
Comparative example 7
The same components and contents as those of the ceramide compound anmei repairing factor in example 7 were used, except that commercially available seaweed extract was used instead of the prepared seaweed extract provided herein.
Control sample
The ceramide compound anmei repairing factor obtained in comparative examples 1, 2, 3, 4, 5, 6 and 7 is used for replacing the ceramide compound anmei repairing factor in example 12, and other components and the content thereof are unchanged, so that comparative emulsion samples 1, 2, 3, 4, 5, 6 and 7 are obtained correspondingly.
The plant preservative of example 12 was replaced with phenoxyethanol/ethylhexylglycerin (0.4%) and the remainder was supplemented with deionized water to give comparative emulsion sample 8.
The ceramide polypeptide compound anmei emulsion described in example 8 to example 12, and comparative emulsion sample 1 to comparative emulsion sample 8, product safety was evaluated as follows:
(1) microbiological test item experiments: according to the determination method of the total number of bacterial colonies, faecal coliform, staphylococcus aureus, pseudomonas, mould and saccharomycetes in the cosmetic hygiene standard, the microorganism detection of the ceramide polypeptide compound anmei emulsion provided by the invention is all qualified.
(2) And (3) testing sanitary chemical inspection projects: according to the method for measuring total mercury, total arsenic and total lead in the cosmetic hygiene standard, the metal elements of the ceramide polypeptide compound anmei emulsion provided by the invention are all qualified.
Efficacy experiments:
1. anti-allergy and anti-irritation
1) According to the basic principle of animal skin irritation or corrosiveness tests specified in the cosmetic hygiene code-2007, requirements and methods for the skin irritation integral mean values of the ceramide polypeptide compound anmei emulsion provided by the example 8 to the example 12 and the comparative emulsion samples 1 to 7 are less than 0.2, which indicates no irritation, and the skin irritation integral mean value of the comparative emulsion sample 8 is 1.0, which has slight irritation.
2) 20 sensitive muscle volunteers were selected and the ceramide polypeptide compound Anmyo emulsion in example 12 was continuously used for 7 days, resulting in 0 person with discomfort or allergy symptoms and 0% allergy rate. One week after the end of the trial, the volunteers of this group used a control emulsion sample of 8 for 7 days, giving rise to discomfort or allergic symptoms in 2 persons with an allergy rate of 10%. Namely, the ceramide polypeptide compound anmeiye of the invention is mild, has no stimulation and has strong anti-allergy property.
2. Moisture retention test:
the specific test method is as follows:
reference standard: refer to QB/T4256-.
The testing personnel: 55 healthy volunteers were selected, aged 30-40 years each.
And (3) testing conditions are as follows: the capacitance method skin moisture tester Corneometer CM825 is used for testing the temperature of 20-22 ℃ and the humidity of 40-60%.
The test principle is as follows: the capacitance method is used for measuring the moisture content of the human skin stratum corneum, and is based on the obvious difference of dielectric constants of water and other substances, the capacitance values of the measured skin are different according to the moisture content of the skin stratum corneum, and the parameters can represent the moisture content (MMV) of the skin.
Test samples: the experimental groups were the products provided for examples 8, 9, 12 and the control groups were comparative emulsion sample 1 to comparative emulsion sample 8.
The test method comprises the following steps: each area is fixedly measured at three points according to a certain sequence, and an average value of the three points is obtained. Then, the ceramide polypeptide compound anmei emulsion is smeared on a tested part (according to (2.0 +/-0.1) mg/cm)2The amount of (c) was applied in a single application), the skin moisture content of the test site was measured at 0h, 1h, 4h and 8h using a probe, and the average value of each group was calculated for the corresponding time point, and the results are shown in table 1.
TABLE 1
The skin moisture content increase rate calculation formula is as follows:
skin moisture content increase rate [ (% MMVt-MMV) ]0)/MMV0×100％
MMV0MMV on the skin before application
MMVtMMV of the skin t periods after application
The results are shown in Table 2.
TABLE 2
3. Skin moisture loss test.
The skin moisture loss (TEWL) tester TM300 of the German CK company is adopted for detection, and the testing method is basically consistent with the skin moisture content (MMV). The test area is a left forearm, each test area is tested for 3 times to obtain an average value, and the percutaneous water loss TEWL value is smaller, the water loss is smaller, and the water locking capacity is stronger; conversely, the weaker the water-holding capacity. The rate of change, and the rate of change of TEWL values, the lower the value, the better the water-locking effect, the results are shown in Table 3.
The lower the rate of change (TEWLt-TEWL0)/TEWL0 x 100%, the lower the water loss, the stronger the skin barrier function of the test sample, and the better the moisturizing effect. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site.
TABLE 3 skin TEWL assay results
4, skin elasticity test
Test samples: the experimental groups were the products provided for examples 8, 9, 12 and the control groups were comparative emulsion sample 1 to comparative emulsion sample 8.
The experimental method comprises the following steps: the testing personnel: 55 healthy volunteers aged 30-40 years were selected, and randomly grouped into 5 groups. The samples were applied twice daily in the morning and evening. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site.
Skin elasticity test: the skin condition of week 0 and week 4 was measured using the skin elastometer MPA580, the test site was the cheekbone, the probe repeated 3 times in the same test area during the measurement, and the average was taken.
The skin elasticity increase rate W ═ NT-N0)/N0×100％
N0-skin elasticity test value before application.
NT-elasticity test value T period after application.
The results of the specific skin elasticity tests are shown in table 4:
TABLE 4
| Detection article | Week 0 | Week 4 | Growth rate (%) |
| Example 8 | 0.69 | 0.91 | 31.88 |
| Example 9 | 0.68 | 0.90 | 32.35 |
| Example 12 | 0.67 | 0.92 | 37.31 |
| Comparative emulsion sample 1 | 0.66 | 0.82 | 24.24 |
| Comparative emulsion sample 2 | 0.66 | 0.80 | 21.21 |
| Comparative emulsion sample 3 | 0.67 | 0.78 | 16.42 |
| Comparative emulsion sample 4 | 0.68 | 0.75 | 10.29 |
| Comparative emulsion sample 5 | 0.69 | 0.75 | 8.70 |
| Comparative emulsion sample 6 | 0.66 | 0.79 | 19.70 |
| Comparative emulsion sample 7 | 0.63 | 0.75 | 19.05 |
| Comparative emulsion sample 8 | 0.62 | 0.73 | 17.74 |
As is apparent from tables 1 to 4, the technical scheme provided by the invention has no skin irritation, can effectively relieve damaged skin, adjust a water-oil balance system of the skin, deeply moisturize and nourish the skin, effectively repair a skin barrier, and protect external irritation.
Claims (4)
1. The ceramide compound muscle-soothing repair factor is characterized by comprising the following components in parts by weight: 112-19 parts of ceramide, 8-11 parts of seaweed extract, 5-7 parts of coix seed extract, 4-6 parts of centella extract, 3-6 parts of wrinkled gianthyssop extract, 3-6 parts of scutellaria root extract, 2-4 parts of common andrographis herb extract, 1-3 parts of camellia leaf extract fermentation product, 1-2 parts of tea seed oil and 1-3 parts of shea butter extract; 1-2 parts of calendula oil; 1-1.2 parts of Gnaphalium affine flower oil, 2-4 parts of Bixiong peach seed extract and 1-2 parts of mung bean seed extract;
the composite fermentation liquid is prepared from an aspergillus/yeast/barley fermentation product extract filtrate, a leuconostoc/radish root fermentation product filtrate and a lactobacillus/rye fine powder fermentation product filtrate in a mass ratio of: 2-4:1-3: 1-3;
the seaweed extract is prepared by the following steps:
(1) cleaning seaweed, sterilizing by ultraviolet, and pulverizing;
(2) adding 70% ethanol 2-5 times the volume of Sargassum into Sargassum, adjusting pH to alkaline, and pulping;
(3) adding complex enzyme with the amount of 1-3% of the seaweed mass into the seaweed slurry, carrying out enzymolysis at 30-40 ℃ for 12-24 hours, then carrying out enzyme deactivation after the enzymolysis is finished, filtering to obtain precipitate and filtrate, and then filtering and collecting crude filtrate;
(4) adding chitosan solution into the filtrate, stirring, filtering with a filter membrane, and collecting the fine filtrate;
(5) concentrating the fine filtrate obtained in the step (4) to obtain a seaweed extract;
wherein the complex enzyme in the step (3) is a mixture of glucoamylase, isoamylase, superoxide dismutase and cellulase.
2. An emulsion containing the ceramide compound anmei repairing factor of claim 1, which is characterized by being prepared from 1-5% of the ceramide compound anmei repairing factor and 5-99% of a matrix by taking the total mass of the emulsion as 100%.
3. The emulsion containing the ceramide compound anmei repairing factor is characterized in that the matrix comprises the following components in percentage by mass based on 100% of the total mass of the matrix: 0.8-1.5% of C12-20 alkyl glucoside, 0.1-1% of sorbitan stearate and 0.1-1.2% of hydrogenated lecithin; 0.1-1% of cyclotetrasiloxane, 0.1-1% of dimethiconol, 0.5-2% of phytosterol oleate, 1-3% of cetearyl alcohol, 1-3% of tetrahydro-methyl pyrimidine carboxylic acid, 0.02-0.1% of disodium EDTA, 3-6% of glycerol and 2-5% of squalane; 0.3-1% of poly-gamma-sodium glutamate, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.5-2% of plant preservative and the balance of deionized water.
4. The ceramide compound anmei repairing factor-containing emulsion according to claim 3, wherein the plant preservative is prepared from chamomile essential oil, sage extract, magnolia officinalis flower extract and zanthoxylum piperitum fruit extract according to the mass ratio: 2-5:2-5:1-3: 1-2.
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| JP2013133324A (en) * | 2011-12-27 | 2013-07-08 | Dhc Co | Skin care preparation |
| CN106265430A (en) * | 2016-08-22 | 2017-01-04 | 彭之玉 | Semen phaseoli radiati ferment licorice peace skin frost and preparation method |
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| JP2013133324A (en) * | 2011-12-27 | 2013-07-08 | Dhc Co | Skin care preparation |
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