CN116850113B - Composition with pore purifying and barrier repairing functions and preparation method thereof - Google Patents
Composition with pore purifying and barrier repairing functions and preparation method thereof Download PDFInfo
- Publication number
- CN116850113B CN116850113B CN202311046175.1A CN202311046175A CN116850113B CN 116850113 B CN116850113 B CN 116850113B CN 202311046175 A CN202311046175 A CN 202311046175A CN 116850113 B CN116850113 B CN 116850113B
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- parts
- extract
- panthenol
- composition
- barrier
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- 230000006870 function Effects 0.000 title claims abstract description 30
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- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 87
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- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 16
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 16
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 16
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 16
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 15
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- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 15
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- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 15
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Classifications
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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Landscapes
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- Emergency Medicine (AREA)
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- Biophysics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a composition with pore purifying and barrier repairing functions and a preparation method thereof, wherein the composition comprises the following raw materials in parts by weight: the invention adopts a method of first metabolism and then repair, uses compound acid and the like to purify pores, uses astringents to control grease secretion, uses ceramides, plankton extracts, cornflower extracts and other agitation factors to inhibit the expression of capsaicin receptor TRPV1, improves and repairs the skin barrier function and achieves the effects of purifying pores and repairing the barrier.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a composition with pore purifying and barrier repairing functions and a preparation method thereof.
Background
The sebum has complex components, mainly containing wax fat, triglyceride and free fatty acid, and also containing phospholipid and cholesterol lipid generated after epithelial cell metabolism. Sebum is oily and has moisturizing effect on skin, thereby preventing dryness and chapping. The fatty acids in sebum kill bacteria and resist mold and viruses, which are known as the natural barrier of skin. Sebum has a certain excretion effect in view of the fact that sebum contains fat-soluble metabolic wastes which are not needed by the body. Sebum has protective and moisturizing effects on skin, but excessive sebum can form seborrheic dermatitis, such as acne, vaccinia, pimple, dandruff, etc.
The formation of mixed or oily skin is caused by excessive secretion of skin grease, the grease secretion is excessive, pores can be enlarged by accumulated grease, the skin color of most people is dark, the pores are large, the skin is greasy and bright, even orange skin appearance can appear, the pH value is between 5.6 and 6.6, dust and dirt are easy to adhere, and skin infection, acne and the like are caused. Is common in young people in adolescence. Excess grease accumulates in the pores, only the larger the pores are squeezed. The grease is wrapped in the skin to become white comedones; skin breaking and blackening due to oxidation in air can form comedones, and more serious and even worsened to form sores. The formation of acne is the grease which should be discharged from pores originally, and because the keratosis around the pores blocks the mixed product, when the acne is more, the pores are also more enlarged, and the corresponding skin diseases of the face, such as itching sores, are easy to occur. Seborrheic dermatitis, and the like. Controlling excessive secretion of sebaceous glands and alleviating oily symptoms is a key to maintaining skin health.
At present, most products for purifying pores absorb grease on the surface of skin by utilizing the adsorption effect of kaolin and bentonite, and cannot dissolve the grease, generate mixed oxidation of ash into solid acne, blackheads and the like; the acid products are used for removing in the market, mainly acids such as salicylic acid or fruit acid are used as main components, the effects of exfoliating cutin, controlling oil and removing acne are achieved, the effects of the products are obvious, but the products are large in irritation, low in pH value and easy to cause skin allergy and the like, and the skin is always in a state of water shortage or unbalanced skin barrier. After the hair follicle is stimulated by the outside world, the skin is easy to have symptoms such as burning, stinging, itching, tightness and the like, with or without symptoms such as erythema, scales, telangiectasis and the like, generally starts from a thin and tender part of the skin, gradually develops to the ear and the neck, and seriously spreads to the whole body.
Disclosure of Invention
In view of the above, the present invention proposes a composition having pore-purifying and barrier-repairing functions and a method for preparing the same, which solve the above-mentioned problems.
The technical scheme of the invention is realized as follows: a composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.3-0.7 part of compound acid, 0.4-0.9 part of menthol, 1-4 parts of medicinal layer porus extract, 15-33 parts of astringent, 14-22 parts of ceramide, 3-9 parts of plankton extract, 1-3 parts of cornflower extract, 13-38 parts of panthenol, 2-6 parts of mallow extract, 33-68 parts of resveratrol and 2-9 parts of astaxanthin, wherein the compound acid comprises ellagic acid, salicylic acid, glycollic acid and retinol with the mass ratio of (12.3-18.3) to (9.8-13.5) to (5.2-14.3) to (0.06-0.08).
Further, the composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.5 part of complex acid, 0.7 part of menthol, 2 parts of medicinal layer porus extract, 27 parts of astringent, 18 parts of ceramide, 6 parts of plankton extract, 2 parts of cornflower extract, 20 parts of panthenol, 4 parts of mallow extract, 45 parts of resveratrol and 5 parts of astaxanthin.
Further, the astringents are fermentation product extracts in soybeans and almonds, specifically, the soybeans and the almonds are crushed into mixed powder with the size of 50-200 meshes, water and amylase are added for enzymolysis reaction to obtain intermediate liquid, saccharomycetes are inoculated into the intermediate liquid for culture, the inoculation amount is 1-3% of the volume of the intermediate liquid, the culture time is 18-24h, the culture temperature is 30-37 ℃, fermentation liquid is obtained, after the culture is completed, the fermentation liquid is centrifuged, supernatant fluid is taken and concentrated, ethanol with the concentration of 52-70% is used for extraction, and the volume ratio of the supernatant fluid to the ethanol is 1-3:5, so that the fermentation product extract is obtained.
Further, the mass volume ratio g/mL of the powder, amylase and water is (21-38): 4-9): 100.
Further, the concentration of the yeast is 1×10 5 -1×10 8 cfu/mL, which is one or a combination of more than one of candida lipolytica, pichia pastoris, beer yeast, candida utilis, hansenula polymorpha, candida utilis and aroma-producing yeast.
Further, the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) with the mass ratio of (59-76) to (12-34) to (6-12).
Further, a method for preparing a composition having pore-purifying and barrier-repairing functions, comprising the steps of:
s1, mixing menthol, a medicinal layer porus extract and an astringent, adding pure water, placing in an ultrasonic oscillator, and treating for 17-25min at 35-45 ℃ under the power of 130-170W to obtain a mixed solution A;
s2, taking the ceramide, plankton extract, cornflower extract, panthenol, malva extract, resveratrol and astaxanthin, stirring at a low speed for 8-12min at a temperature of 32-38 ℃, and then magnetically stirring for 20-30min to obtain a mixed material B;
s3, mixing the mixed solution A and the mixed solution B, placing the mixture into a homogenizer, homogenizing the mixture for 15-35min under 13-18MPa, homogenizing the mixture for 5-10min under 25-35MPa, adding the compound acid, and ultrasonically dissolving the mixture for 10-20min to obtain the composition with pore purifying and barrier repairing functions.
Further, the addition amount of the pure water in the step S1 is 2-6 times of the mass of the mixture.
Further, the low-speed stirring speed in the step S2 is 100-300rpm, and the magnetic stirring speed is 600-800rpm.
Further, the temperature of ultrasonic dissolution in the step S3 is 35-42 ℃, the frequency is 14-100KHz, and the power is 10-30w.
Compared with the prior art, the invention has the beneficial effects that:
the composition adopts the scientific proportion of the raw materials such as the compound acid, the astringing agent, the plankton extract, the cornflower extract and the like, adopts the principle of metabolism and repair firstly, uses the compound acid to dredge pores, then uses the astringing agent and the medicinal layer porus extract to inhibit grease secretion, contains trace living bacteria which can effectively inhibit propionibacterium acnes causing acnes in the pores, achieves the effect of bacterial treatment, and finally selects panthenol and ceramide with a certain proportion to have the capabilities of moisturizing and repairing skin, can provide moisturizing and relieving effects, reduces skin dryness and irritation, enables the cornflower extract to inhibit the expression of capsaicin receptor V1 from the source, reduces skin uncomfortable reaction, enables the skin barrier function to be more stable under three-tube conditions, can repair skin at the same time of better purification, has the reduction rate of the grease content of 50.1-52.9%, the reduction rate of acnes quantity of 82.3-88.9%, has the aperture shrinkage rate of 63.8-69.8%, and has the conditions of deep skin after deep skin is purified, and has no skin itching, hot and has no skin itching, or other conditions;
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
Example 1
A composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.3 part of complex acid, 0.4 part of menthol, 1 part of medicinal layer porus extract, 15 parts of astringent, 14 parts of ceramide, 3 parts of plankton extract, 1 part of cornflower extract, 13 parts of panthenol, 2 parts of mallow extract, 33 parts of resveratrol and 2 parts of astaxanthin;
the complex acid comprises ellagic acid, salicylic acid, glycollic acid and retinol in a mass ratio of 12.3:9.8:5.2:0.06;
the astringents are fermentation product extracts in soybeans and almonds, and are specifically prepared by crushing the soybeans and the almonds into mixed powder with the size of 50 meshes, adding water and amylase for enzymolysis reaction to obtain intermediate liquid, inoculating saccharomycetes into the intermediate liquid for culture, wherein the mass volume ratio g/mL of the powder, the amylase and the water is 21:4:100, the inoculation amount is 1% of the volume of the intermediate liquid, the culture time is 18 hours, the culture temperature is 30 ℃, obtaining fermentation liquid, centrifuging the fermentation liquid after the culture is finished, concentrating supernatant, extracting with ethanol with the concentration of 52%, and the volume ratio of the supernatant to the ethanol is 1:5 to obtain the fermentation product extract; above-mentionedThe concentration of the saccharomycetes is 1 multiplied by 10 5 cfu/mL, which is Candida lipolytica;
the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) in a mass ratio of 59:12:6.
Example 2
A composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.7 part of complex acid, 0.9 part of menthol, 4 parts of medicinal layer porus extract, 33 parts of astringent, 22 parts of ceramide, 9 parts of plankton extract, 3 parts of cornflower extract, 38 parts of panthenol, 6 parts of mallow extract, 68 parts of resveratrol and 9 parts of astaxanthin;
the complex acid comprises ellagic acid, salicylic acid, glycollic acid and retinol in a mass ratio of 18.3:13.5:14.3:0.08;
the astringents are fermentation product extracts in soybeans and almonds, and are specifically prepared by crushing the soybeans and the almonds into 200-mesh mixed powder, adding water and amylase for enzymolysis reaction to obtain intermediate liquid, inoculating saccharomycetes into the intermediate liquid for culture, wherein the mass volume ratio g/mL of the powder, the amylase and the water is 38:9:100, the inoculation amount is 3% of the volume of the intermediate liquid, the culture time is 24 hours, the culture temperature is 37 ℃, obtaining fermentation liquid, centrifuging the fermentation liquid after the culture is finished, concentrating supernatant, extracting with 70% ethanol, and the volume ratio of the supernatant to the ethanol is 3:5 to obtain the fermentation product extract; the concentration of the yeast is 1×10 8 cfu/mL, which is Pichia pastoris;
the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) in a mass ratio of 76:34:12.
Example 3
A composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.5 part of complex acid, 0.7 part of menthol, 2 parts of medicinal layer porus extract, 27 parts of astringent, 18 parts of ceramide, 6 parts of plankton extract, 2 parts of cornflower extract, 20 parts of panthenol, 4 parts of mallow extract, 45 parts of resveratrol and 5 parts of astaxanthin;
the complex acid comprises ellagic acid, salicylic acid, glycollic acid and retinol in a mass ratio of 15.2:11.8:10.3:0.07;
the astringents are fermentation product extracts in soybeans and almonds, and are specifically prepared by crushing the soybeans and the almonds into mixed powder of 50-200 meshes, adding water and amylase for enzymolysis reaction to obtain intermediate liquid, inoculating saccharomycetes into the intermediate liquid for culture, wherein the mass volume ratio g/mL of the powder, the amylase and the water is 31:7:100, the inoculum size is 2% of the volume of the intermediate liquid, the culture time is 21 hours, the culture temperature is 34 ℃, obtaining fermentation liquid, centrifuging the fermentation liquid after the culture is finished, concentrating supernatant, extracting with ethanol with the concentration of 60%, and the volume ratio of the supernatant to the ethanol is 2:5 to obtain the fermentation product extract; the concentration of the yeast is 1×10 7 cfu/mL, which is candida lipolytica and candida incense in a mass ratio of 1:1;
the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) in a mass ratio of 65:22:9.
Examples 1-3 above were prepared using the following preparation method,
s1, mixing menthol, a medicinal layer porus extract and an astringent, adding pure water with the mass of 4 times of that of the mixture, and placing the mixture in an ultrasonic oscillator for 21min at the temperature of 40 ℃ and the power of 150W to obtain a mixed solution A;
s2, taking the ceramide, plankton extract, cornflower extract, panthenol, malva extract, resveratrol and astaxanthin, stirring at a low speed of 200rpm for 10min at a temperature of 35 ℃, and then stirring at a magnetic rotation speed of 700rpm for 25min to obtain a mixed material B;
s3, mixing the mixed solution A and the mixed solution B, placing the mixture into a homogenizer, homogenizing the mixture for 25min under 15MPa, homogenizing the mixture for 8min under 30MPa, adding the compound acid, and performing ultrasonic dissolution for 15min at 38 ℃ at 58KHz with 20w power to obtain the composition with pore purifying and barrier repairing functions.
Example 4
A composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.5 part of complex acid, 0.7 part of menthol, 2 parts of medicinal layer porus extract, 27 parts of astringent, 18 parts of ceramide, 6 parts of plankton extract, 2 parts of cornflower extract, 20 parts of panthenol, 4 parts of mallow extract, 45 parts of resveratrol and 5 parts of astaxanthin;
the complex acid comprises ellagic acid, salicylic acid, glycollic acid and retinol in a mass ratio of 15.2:11.8:10.3:0.07;
the astringents are fermentation product extracts in soybeans and almonds, and are specifically prepared by crushing the soybeans and the almonds into mixed powder of 50-200 meshes, adding water and amylase for enzymolysis reaction to obtain intermediate liquid, inoculating saccharomycetes into the intermediate liquid for culture, wherein the mass volume ratio g/mL of the powder, the amylase and the water is 31:7:100, the inoculum size is 2% of the volume of the intermediate liquid, the culture time is 21 hours, the culture temperature is 34 ℃, obtaining fermentation liquid, centrifuging the fermentation liquid after the culture is finished, concentrating supernatant, extracting with ethanol with the concentration of 60%, and the volume ratio of the supernatant to the ethanol is 2:5 to obtain the fermentation product extract; the concentration of the yeast is 1×10 7 cfu/mL, which is candida lipolytica and candida incense in a mass ratio of 1:1;
the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) in a mass ratio of 65:22:9;
s1, mixing menthol, a medicinal layer porus extract and an astringent, adding pure water with the mass of 2 times of that of the mixture, and placing the mixture in an ultrasonic oscillator for 17min at the temperature of 35 ℃ and the power of 130W to obtain a mixed solution A;
s2, taking the ceramide, plankton extract, cornflower extract, panthenol, malva extract, resveratrol and astaxanthin, stirring at a low speed of 100rpm for 8min at a temperature of 32 ℃, and stirring at a magnetic rotation speed of 600rpm for 20min to obtain a mixed material B;
s3, mixing the mixed solution A and the mixed solution B, placing the mixture into a homogenizer, homogenizing the mixture for 15min under 13MPa, homogenizing the mixture for 5min under 25MPa, adding the compound acid, and performing ultrasonic dissolution for 10min at 35 ℃ at a frequency of 14KHz with a power of 10w to obtain the composition with pore purifying and barrier repairing functions.
Example 5
A composition with pore purifying and barrier repairing functions comprises the following raw materials in parts by weight: 0.5 part of complex acid, 0.7 part of menthol, 2 parts of medicinal layer porus extract, 27 parts of astringent, 18 parts of ceramide, 6 parts of plankton extract, 2 parts of cornflower extract, 20 parts of panthenol, 4 parts of mallow extract, 45 parts of resveratrol and 5 parts of astaxanthin;
the complex acid comprises ellagic acid, salicylic acid, glycollic acid and retinol in a mass ratio of 15.2:11.8:10.3:0.07;
the astringents are fermentation product extracts in soybeans and almonds, and are specifically prepared by crushing the soybeans and the almonds into mixed powder of 50-200 meshes, adding water and amylase for enzymolysis reaction to obtain intermediate liquid, inoculating saccharomycetes into the intermediate liquid for culture, wherein the mass volume ratio g/mL of the powder, the amylase and the water is 31:7:100, the inoculum size is 2% of the volume of the intermediate liquid, the culture time is 21 hours, the culture temperature is 34 ℃, obtaining fermentation liquid, centrifuging the fermentation liquid after the culture is finished, concentrating supernatant, extracting with ethanol with the concentration of 60%, and the volume ratio of the supernatant to the ethanol is 2:5 to obtain the fermentation product extract; the concentration of the yeast is 1×10 7 cfu/mL, which is candida lipolytica and candida incense in a mass ratio of 1:1;
the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) in a mass ratio of 65:22:9;
s1, mixing menthol, a medicinal layer porus extract and an astringent, adding pure water with the mass of 2-6 times of that of the mixture, and placing the mixture in an ultrasonic oscillator for 17-25min at the temperature of 35-45 ℃ and the power of 130-170W to obtain a mixed solution A;
s2, taking the ceramide, plankton extract, cornflower extract, panthenol, malva extract, resveratrol and astaxanthin, stirring at a low speed of 300rpm for 12min at a temperature of 38 ℃, and then stirring at a magnetic rotation speed of 800rpm for 30min to obtain a mixed material B;
s3, mixing the mixed solution A and the mixed solution B, placing the mixture into a homogenizer, homogenizing the mixture for 35min under 18MPa, homogenizing the mixture for 10min under 35MPa, adding the compound acid, and performing ultrasonic dissolution for 20min at 42 ℃ at 100KHz with 30w power to obtain the composition with pore purifying and barrier repairing functions.
Comparative example 1
The difference between this comparative example and example 3 is that a composition having pore-purifying and barrier-repairing functions comprises the following raw materials in parts by weight: 0.1 part of complex acid, 0.2 part of menthol, 5 parts of medicinal layer porus extract, 65 parts of astringent, 35 parts of ceramide, 12 parts of plankton extract, 5 parts of cornflower extract, 8 parts of panthenol, 10 parts of mallow extract, 25 parts of resveratrol and 1 part of astaxanthin.
Comparative example 2
This comparative example differs from example 3 in that a composition having pore-cleaning and barrier-repairing functions is replaced by an equivalent amount of azelaic acid.
Comparative example 3
This comparative example differs from example 3 in that a composition, a medicinal layer porus extract, has the functions of purifying pores and repairing barriers.
Comparative example 4
This comparative example differs from example 3 in that a composition having pore-cleansing and barrier-repairing functions does not contain an astringent.
Comparative example 5
This comparative example differs from example 3 in that a composition having pore-cleansing and barrier-repairing functions does not contain cornflower extract.
Comparative example 6
This comparative example differs from example 3 in that a composition having pore-cleansing and barrier-repairing functions does not contain plankton extract.
1. Safety test
The compositions of examples 1-5 and comparative examples 1-6 were subjected to animal skin irritation test, skin sensitization test and in vitro cytotoxicity test, respectively, and the results showed that the compositions of the present invention were safe and nontoxic, indicating that the compositions of the present invention were safe and non-irritating.
2. In vitro test
1. Experimental samples: the compositions prepared in the examples 1-5 and the comparative examples 1-6 according to the invention are added into skin care emulsion according to the addition amount of 15wt percent, and are divided into experimental groups 1-10, and a control group is a commercial skin care product with acid purification pores in a certain brand;
2. subjects and samples: 120 volunteers were selected, with a male/female ratio of 2:1, the ages are 16-36 years, no skin history exists, the skin is oily and oily sensitive skin (which is easy to cause stinging, redness, itching and acne, and the skin is broken into 12 groups of 10 people, and the groups correspond to examples 1-5, comparative examples 1-6 and a control group respectively;
3. the experimental method comprises the following steps: the subjects smeared the experimental group products on the T area of the face (forehead, nose and chin) every 2 days, and used for 8 weeks continuously, and the grease content, the acne quantity reduction rate and the pore diameter change rate of the T area of the face are respectively tested before and after the use, and then the experimental group products are calculated by the following formulas:
lipid content decrease rate= (lipid content Front part -oil content Rear part (S) ) Fat content Front part ×100％，
Acne amount reduction rate= (acne amount) Front part Number of acne Rear part (S) ) Number of acnes Front part ×100％，
Aperture shrinkage= (aperture Front part -pore size Rear part (S) ) Aperture/diameter Front part ×100％
4. Experimental results:
compared with the commercial skin care products, the composition prepared by the invention has better effect of purifying pores, effectively inhibits sebum secretion of pores, has the lipid content reduction rate of 50.1-52.9%, inhibits propionibacterium acnes from growing, reduces acnes from growing, has the acne quantity reduction rate of 82.3-88.9%, has obvious acne removal effect, and plays a role in deeply cleaning the pores, thereby achieving the effect of shrinking the pores, and has the aperture shrinkage rate of 63.8-69.8%, so that skin is more thoroughly cleaned.
The comparison of the present example with comparative example 1 shows that the raw materials act synergistically under specific proportion, and effectively achieve the effect of pore purification, and compared with comparative example 2, the present invention prepares the compound acid according to proportion, selects the liposoluble acid, can enter skin deep layer to dissolve grease, dredge pores, accelerate skin metabolism, exfoliate aging cutin, ellagic acid can astringe sweat glands to reduce sweat secretion, salicylic acid can permeate skin, balance skin oil-water balance, and control grease secretion; glycolic acid not only helps to clear dirt and dead skin from the face, but also has the ability to penetrate deep into the hair follicle, loosening accumulated sebum or protein; retinol promotes cell proliferation, maintains normal circulation of skin, and also promotes cell proliferation and maintains normal circulation of skin; complex acids can also help skin to better absorb skin care products;
compared with comparative example 3, the prebiotics and the organic acid added into the medicinal layer porus extract can solve the problem of skin grease transitional secretion, reduce the blockage of follicular orifice, and have the effects of astringing skin, shrinking pores and smoothing and tightening skin;
compared with comparative example 4, the fermentation product extract of the soybeans and the almonds is added with the astringents, and trace living bacteria can effectively inhibit propionibacterium acnes causing acnes in pores, so that the effect of bacterial treatment is achieved.
5. The repairing effect is as follows:
comparative example 7 was set: 10 oil-sensitive muscle volunteers were selected as comparative example 7, who had developed reddening, burning, and acne;
the above results show that the purification effect of example 3 is optimal, and that the skin pores are deeply purified, and the conditions such as burning, stinging, redness, itching, popping and the like are caused by irritation, and the values of a reddish area a of forehead skin, the water loss value of the epidermis of TEWL and the skin heme value are measured for examples 3, comparative examples 5, 6 and 7.
TEWL refers to facial transcutaneous moisture loss and stratum corneum moisture content, the lower the value, the higher the stratum corneum moisture content value, the better the skin barrier function; the worse the reverse is.
TEWL value: health status (0-15), sub-health status (15-25), disease status (> 25);
heme content: the normal value of adult males is 120-160g/L, and the normal value of adult females is 110-150g/L;
the test results were as follows:
from the results, the composition plays a role in repairing barriers while controlling oil and purifying pores, and from comparative example 7, the composition can achieve a certain repairing effect on the conditions of redness, burning and acne; example 3 compared to comparative example 5 shows that the addition of cornflower extract can rapidly extinguish the agitation factor from the source; compared with the opposite 6, the plankton extract inhibits the expression of capsaicin receptor TRPV1, reduces skin discomfort reaction and makes the skin barrier function more stable.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (6)
1. A composition having pore-cleansing and barrier-repair functions, characterized by: the material comprises the following raw materials in parts by weight: 0.3-0.7 part of compound acid, 0.4-0.9 part of menthol, 1-4 parts of medicinal layer porus extract, 15-33 parts of astringent, 14-22 parts of ceramide, 3-9 parts of plankton extract, 1-3 parts of cornflower extract, 13-38 parts of panthenol, 2-6 parts of mallow extract, 33-68 parts of resveratrol and 2-9 parts of astaxanthin, wherein the compound acid comprises ellagic acid, salicylic acid, glycollic acid and retinol with the mass ratio of (12.3-18.3) to (9.8-13.5) to (5.2-14.3) to (0.06-0.08); the astringent is fermentation product extract of semen glycines and semen Armeniacae amarum, specifically is prepared by pulverizing semen glycines and semen Armeniacae amarum into 50-200 mesh mixed powder, adding water and amylase, and performing enzymolysis reaction to obtain intermediate solution, wherein the powder, amylase and waterThe mass volume ratio g/mL is (21-38): 4-9): 100, and then the saccharomycetes are inoculated into the intermediate liquid for culture, wherein the inoculation amount is 1-3% of the volume of the intermediate liquid, and the concentration of the saccharomycetes is 1 multiplied by 10 5 -1×10 8 cfu/mL which is one or a combination of candida lipolytica, pichia pastoris, beer yeast, candida utilis, hansenula polymorpha, candida and aroma-producing yeast, wherein the culture time is 18-24 hours, the culture temperature is 30-37 ℃, fermentation liquor is obtained, after the culture is completed, the fermentation liquor is centrifuged, supernatant fluid is taken and concentrated, ethanol with the concentration of 52-70% is used for extraction, and the volume ratio of the supernatant fluid to the ethanol is 1-3:5, so as to obtain a fermentation product extract; the panthenol is composed of D-panthenol (dextrorotation), L-panthenol (levorotatory) and DL-panthenol (mixed rotatory) with the mass ratio of (59-76) to (12-34) to (6-12).
2. A composition having pore-purifying and barrier-repairing functions as claimed in claim 1, wherein: the material comprises the following raw materials in parts by weight: 0.5 part of complex acid, 0.7 part of menthol, 2 parts of medicinal layer porus extract, 27 parts of astringent, 18 parts of ceramide, 6 parts of plankton extract, 2 parts of cornflower extract, 20 parts of panthenol, 4 parts of mallow extract, 45 parts of resveratrol and 5 parts of astaxanthin.
3. A method of preparing a composition having pore-cleaning and barrier-repair functions as claimed in claim 1, wherein: the method comprises the following steps:
s1, mixing menthol, a medicinal layer porus extract and an astringent, adding pure water, placing in an ultrasonic oscillator, and treating for 17-25min at 35-45 ℃ under the power of 130-170W to obtain a mixed solution A;
s2, taking the ceramide, plankton extract, cornflower extract, panthenol, malva extract, resveratrol and astaxanthin, stirring at a low speed for 8-12min at a temperature of 32-38 ℃, and then magnetically stirring for 20-30min to obtain a mixed material B;
s3, mixing the mixed solution A and the mixed solution B, placing the mixture into a homogenizer, homogenizing the mixture for 15-35min under 13-18MPa, homogenizing the mixture for 5-10min under 25-35MPa, adding the compound acid, and ultrasonically dissolving the mixture for 10-20min to obtain the composition with pore purifying and barrier repairing functions.
4. A method of preparing a composition having pore-cleaning and barrier-repair functions as claimed in claim 3, wherein: the adding amount of the pure water in the S1 is 2-6 times of the mass of the mixture.
5. A method of preparing a composition having pore-cleaning and barrier-repair functions as claimed in claim 3, wherein: the low-speed stirring speed in the step S2 is 100-300rpm, and the magnetic stirring speed is 600-800rpm.
6. A method of preparing a composition having pore-cleaning and barrier-repair functions as claimed in claim 3, wherein: the temperature of ultrasonic dissolution in the step S3 is 35-42 ℃, the frequency is 14-100KHz, and the power is 10-30w.
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| KR20090002677A (en) * | 2007-07-02 | 2009-01-09 | 주식회사 엘지생활건강 | Cosmetic composition having antioxidation activity |
| CN111494299A (en) * | 2020-05-26 | 2020-08-07 | 佛山市谷邦生物科技有限公司 | Ceramide compound muscle-calming repair factor and emulsion thereof |
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2023
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090002677A (en) * | 2007-07-02 | 2009-01-09 | 주식회사 엘지생활건강 | Cosmetic composition having antioxidation activity |
| CN111494299A (en) * | 2020-05-26 | 2020-08-07 | 佛山市谷邦生物科技有限公司 | Ceramide compound muscle-calming repair factor and emulsion thereof |
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