CN114917178A - Soothing and repairing composition suitable for dry skin in desert and application thereof - Google Patents
Soothing and repairing composition suitable for dry skin in desert and application thereof Download PDFInfo
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- CN114917178A CN114917178A CN202210593519.XA CN202210593519A CN114917178A CN 114917178 A CN114917178 A CN 114917178A CN 202210593519 A CN202210593519 A CN 202210593519A CN 114917178 A CN114917178 A CN 114917178A
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- desert
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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Abstract
The invention provides a soothing and repairing composition suitable for dry skin in desert and application thereof. The soothing and repairing composition suitable for dry skin in desert is prepared from scutellaria alpina extract, panthenol and bofenate spirulina extract. The soothing and repairing composition is applied to a soothing and repairing essence, and comprises, by mass, 0.6% -20% of the soothing and repairing composition, 5% -20% of polyhydric alcohol, 0.01% -0.05% of a chelating agent, 0.01% -0.5% of a pH regulator, 0.1% -1% of a preservative, 0.1% -0.5% of a thickening agent, and the balance of a solvent to 100%. The skin care cream is prepared by compounding the scutellaria alpina extract, the panthenol and the bofenate spirulina extract according to a specific proportion, and according to different mechanisms of all components, the skin care cream can play a synergistic effect on all paths of skin inflammatory reaction, relieve irritation, repair barriers, effectively improve various problems of skin sensitivity, redness, dryness, prickling and the like of desert skin and enable the skin to recover a healthy state.
Description
Technical Field
The invention relates to the field of daily chemicals, and in particular relates to a soothing and repairing composition suitable for dry skin in desert and application thereof.
Background
The desert muscle is a dry skin in an external environment, the skin is rough, red hot and desquamated, the skin is dry as in desert, the desert muscle is not all natural, and the acquired reasons of the desert muscle are many and are long-term damage accumulation processes, such as frequent solarization, long-term care, frequent use of cosmetics and makeup removal, irregular skin care products or improper skin care, use of hormone ointment and the like. Desert skin is easy to age, dry skin has insufficient secretion of water and oil, and skin lipid film is weak and is easy to be stimulated and sensitive by external. Sensitivity causes cell inflammation, influences normal skin physiological functions such as self-repair and renewal, and can also generate certain destructive factors, so that the deep layer of the skin is damaged, if the skin is not nursed, the dryness condition is further worsened, the aging process of the skin is necessarily accelerated, the appearance of the skin is rough and dull, and the skin also appears to be aged.
At present, the skin sensitivity is generally considered not to belong to the category of skin diseases, but is a metastable skin, sensitive muscles have the characteristics of unobvious symptom expression, uncertain reasons, uncertain relieving methods and the like, and the skin sensitivity state needs to be relieved or avoided by means of skin care, adjustment of living environment and habits, avoidance of contact with stimuli and the like. Therefore, proper use of care products is very essential for people with sensitive muscles.
The existing relieving products on the market mainly utilize anti-allergic agents to prevent inflammatory reaction or add some nerve sensation blocking raw materials, such as TRPV1 receptor (capsaicin receptor) to block nerve signal transmission to achieve the effect of temporarily eliminating stabbing pain, but for desert dry skin, the effect of relieving and repairing the desert dry skin cannot be achieved by simply inhibiting inflammatory reaction and blocking nerve sensation, and for the desert dry skin, the skin barrier is damaged, so the damaged skin barrier needs to be repaired to restore the health of the skin.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a soothing and repairing composition suitable for desert dry skin, which is used for solving the problems of inflammation, sensitivity and the like of the skin, repairing a skin barrier and improving the capability of the skin for resisting adverse factors.
As a first aspect of the present invention, the soothing and repairing composition for dry desert skin of the present invention is composed of the following components: scutellariae radix extract, panthenol and Bonnati Spirulina extract.
Preferably, the soothing and repairing composition suitable for dry skin in desert comprises the following components in parts by weight: 0.1-5 parts of scutellaria alpina extract, 0.1-10 parts of panthenol and 0.1-5 parts of bofenate spirulina extract.
More preferably, the soothing and repairing composition suitable for dry desert skin comprises the following components in parts by weight: 0.3-4 parts of scutellaria alpina extract, 0.3-5 parts of panthenol and 0.2-3 parts of bofenate spirulina extract.
More preferably, the soothing and repairing composition suitable for dry desert skin comprises the following components in parts by weight: 0.5-3 parts of scutellaria alpina extract, 0.5-3 parts of panthenol and 0.3-1 part of bofenate spirulina extract.
The scutellaria alpina extract has a long history as a traditional medicine in China and Europe, has the effects of diminishing inflammation, resisting bacteria, clearing heat, resisting oxidation and the like, is selected from the scutellaria alpina extract from Alps, grows at the altitude of 1500-. Environmental pollution and living pressure can cause great burden to the skin of people at present, the factors can make the skin of people become more sensitive, the skin is stimulated, the people feel uncomfortable, certain abnormal situations such as red rash appear, and the people can be burnt in sense. Stabbing pain, dryness, tension, itching, etc. TRPV1 receptor is the key factor of the process, TRPV1 can mediate neurogenic inflammation, scutellaria alpina extract can inhibit TRPV1 receptor activation to reduce discomfort of nerve sense, scutellaria alpina extract can promote GABAB receptor and up-regulate beta-endorphin, resist skin barrier damage, reduce stimulation and reduce the degree of negative feeling of sensitive skin.
Panthenol, also known as vitamin B5, is converted into pantothenic acid in vivo, is present in tissues after being synthesized into coenzyme a by the tissues, and is an essential substance for the cells to perform substance metabolism, so that long-term use of vitamin B5 can improve cell viability, repair damaged skin, and enhance skin barrier function, thereby significantly reducing the trans-dermal water loss (TEWL). The damaged skin such as sensitive muscle, pockmarked muscle, hormone face and the like is essentially the skin surface with inflammation of different degrees and damaged skin barrier, and the panthenol can promote the growth of epithelial cells, repair the skin and well restore the health state of the skin.
The Bonnet spirulina extract, spirulina, is considered as a valuable source of natural antioxidants due to the abundance of phycocyanin, polyphenol and protein, gamma-linolenic acid, beta-carotene, inositol, spirulina polysaccharide, essential amino acids, vitamin B12, etc. The history of human culture and utilization of spirulina is very long, and the spirulina polysaccharide has very wide application in the field of food and medicine, wherein the spirulina polysaccharide has good effects of resisting tumors, resisting oxidation, regulating immunity, reducing blood sugar and blood fat, repairing DNA damage and the like as an important physiological active substance of spirulina. When the skin is injured or aged, the barrier function of the human skin is damaged, and the skin is dry, sensitive, sallow, flaky erythema, desquamation and the like, and loses the healthy luster and elasticity. The Bolete spirulina extract can promote the repair of skin barrier, reduce water loss of skin and resist external stimulation injury.
Wherein the panthenol can improve the vitality of cells, promote the growth of epithelial cells, repair damaged skin and accelerate the recovery and healing of the damaged skin; the Scutellaria alpina extract can resist in vivo inflammatory reaction and reduce red pain and itch; the Bonnate spirulina extract contains spirulina polysaccharide, can repair cell DNA, also contains a large amount of polyphenols, has good oxidation resistance, can resist in-vivo oxidative stress reaction, reduces in-vivo oxidative damage, and can form a breathable waterproof film on skin to reduce percutaneous water loss of the skin so as to achieve the effect of moisturizing and repairing. The inventor finds that the three components are reasonably compounded, are compatible with each other, have a synergistic effect, and can effectively improve various problems of sensitive skin, reddening, dryness, stabbing pain and the like of desert skin.
Wherein, the panthenol can improve the vitality of cells, promote the growth of epithelial cells, repair damaged skin and accelerate the recovery and healing of the damaged skin; the Scutellariae radix extract can resist in vivo inflammation, and reduce red pain and itch; the Bonnate spirulina extract contains spirulina polysaccharide, can repair cell DNA, also contains a large amount of polyphenols, has good oxidation resistance, can resist in-vivo oxidative stress reaction, reduces in-vivo oxidative damage, and can form a breathable waterproof film on skin to reduce percutaneous water loss of the skin so as to achieve the effect of moisturizing and repairing.
The invention also provides application of the soothing and repairing composition in cosmetics, and the soothing and repairing composition can effectively repair skin corresponding to the cosmetics.
As a second aspect of the present invention, the present invention also provides the use of the above soothing and repairing composition suitable for dry skin in desert, wherein the soothing and repairing composition is mainly used for preparing cosmetics for facial care, and the corresponding cosmetics comprise astringent, essence, lotion, cream, mask, sunscreen, face cleaning product, etc.
As a third aspect of the invention, the invention further provides a soothing and repairing essence, which comprises, by mass, 0.6% -20% of the soothing and repairing composition, 5% -20% of polyhydric alcohol, 0.01% -0.05% of a chelating agent, 0.01-0.5% of a PH regulator, 0.1% -1% of a preservative, 0.1-0.5% of a thickening agent, and the balance of a solvent to 100%, wherein the solvent is at least one of deionized water, distilled water, ion exchange water, double distilled water, high purity water, and purified water.
As a preferred embodiment of the soothing and repairing essence of the present invention, wherein the polyhydric alcohol is preferably at least one selected from the group consisting of glycerin, 1, 3-propanediol, butanediol, dipropylene glycol, 1, 2-pentanediol, sorbitol, erythritol;
the thickener is preferably at least one of carbomer, xanthan gum, hydroxyethyl cellulose, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and sodium polyacrylate;
the chelating agent is preferably disodium EDTA;
the pH regulator is preferably at least one of aminomethyl propanol, triethanolamine and arginine;
the preservative is preferably at least one of 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol, methylparaben and caprylyl hydroximic acid.
In a specific preferred embodiment, the soothing and repairing essence consists of the following components in percentage by mass: 0.05% of EDTA disodium, 0.05% of xanthan gum, 0.15% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 5% of butanediol, 2% of glycerol, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of arginine and 2% of Scutellaria alpina extract; 2% of panthenol, 0.8% of Botani spirulina extract and the balance of deionized water to 100%.
The invention has the beneficial effects that:
the soothing and repairing composition suitable for the dry skin in the desert is prepared by compounding the scutellaria alpina extract, the panthenol and the bofenate spirulina extract according to a specific proportion, and according to different mechanisms of the components, the composition can play a synergistic effect on various channels of skin inflammatory reaction, relieve irritation, repair barriers, effectively improve various problems of skin sensitivity, redness, dryness, stabbing pain and the like of the skin in the desert, and enable the skin to recover a healthy state.
The soothing and repairing composition is applied to facial care products, and the corresponding care products have the effects of soothing and repairing skin, effectively reducing the skin and repairing the skin barrier function.
Drawings
FIG. 1 is a graph showing the results of an interleukin inhibition test of the present invention, wherein the ordinate represents the average IL-1 α concentration;
FIG. 2 is a schematic diagram showing the results of the skin transdermal water loss test of the present invention;
FIG. 3 is a graph showing the result of the hemoglobin content test of the skin according to the present invention;
fig. 4 is a graph of the skin effect of the soothing and rejuvenating essence of example 3 according to the present invention over different periods of time.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
The essences of examples 1 to 4 and comparative examples 1 to 6 were prepared according to the mass percentages of the components in table 1 below.
Table 1, examples 1-4 and comparative examples 1-6
The soothing and repairing essence of examples 1-4 and the essence of comparative examples 1-6 were prepared according to the following steps:
s1: sequentially adding deionized water, acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, disodium EDTA, glycerol, butanediol, p-hydroxyacetophenone and 1, 2-hexanediol into an emulsifying pot, stirring and heating to 80-85 ℃, homogenizing, keeping the temperature for 20 minutes, and stirring uniformly;
s2: adding arginine, homogenizing for 1 minute, and stirring for 15 minutes under heat preservation;
s3: cooling to 40-50 deg.C, adding phase C components, and stirring; thus, the soothing repair essence of examples 1-4 and the essence of comparative examples 1-6 were obtained.
Test of Experimental results
1. Lactic acid sting test
1. And (3) testing a sample: essence obtained in example 1 and comparative example 6
2. Subject: 20 healthy subjects with age between 18 and 55 years were evaluated by questionnaires for dry and sensitive skin in desert and met the criteria for inclusion in the subjects.
3. The test method comprises the following steps: after cleansing the face in the morning and evening, about 1g of the test sample was taken, tapped on the face until absorption, used once in the morning and evening for 28 consecutive days, half-face control, half-face on one side using the composition of example 1, half-face on the other side using the composition of comparative example 6, during which no other skin care product or similar efficacy product was used; lactic acid sting tests were performed before and after use of the product at D0 and D28, respectively. At room temperature, a 10% lactic acid solution was applied to the nasolabial folds and any one cheek at 2.5min and 5min, respectively, and scored by 4 points (0 for no stinging sensation, 1 for mild stinging, 2 for moderate stinging, and 3 for severe stinging) based on the subjective symptoms of the subject. The two fractions are added, and the lactic acid stabbing pain reaction is positive if the total score is more than or equal to 3.
The test observation shows that the results are shown in the following table 2, specifically: the average score of lactic acid stinging response at screening of the test subjects was 4.49 and 4.52, and the average score of lactic acid stinging response after 28 days of product use was 2.65 for example 1 and 4.42 for the comparative example, respectively. The fraction of lactic acid stinging response after 28 days of product use was significantly reduced compared to when screened prior to product use, as tested by Wilcoxon.
TABLE 2 evaluation table of lactic acid stabbing pain test results before and after product use
| Time of measurement | Example 1 | Comparative example 6 |
| D0 | 4.49 | 4.52 |
| D28 | 2.65 | 4.42 |
From the above tests, the sensitivity of the skin became small and the tolerance was enhanced, and it can be seen that example 1 had a certain soothing and repairing effect.
2. Interleukin-1 alpha (IL-1 alpha) inhibition assay
In the experiment, lipopolysaccharide is adopted to stimulate macrophage to establish an inflammation model, and the relieving effect of the test object to be tested is evaluated by detecting the IL-1 alpha secretion after the test object acts.
The test method comprises the following steps: by 6.4X 10 5 Cell/well inoculation Density cells were plated onto 6-well plates, incubators (37 ℃, 5% CO) 2 ) And incubated overnight. When the cell plating rate in the 6-hole plate reaches 40% -60%, the administration is carried out in groups, the administration amount of each hole is 1.8mL, each group is provided with 3 multiple holes, and an incubator (37 ℃, 5% CO) 2 ) The cultivation was continued for 2 h. After 2h of incubation, 200 Lipopolysaccharide (LPS) working solutions experimentally prepared from the essence working solutions of the respective groups of example 2, example 4 and comparative examples 1-6 were added to the administered well plates according to experimental design, and the well plates were shaken left and right to mix the drugs in the well plates to a final concentration of LPS of l μ g/mL, and an incubator (37 ℃, 5% CO at 5 ℃), respectively 2 ) The cultivation was continued for 22 h. After the incubation is finished, collecting cell culture supernatant in an EP tube, and detecting the content of IL-1 alpha.
The test substances were the essences of the groups of example 2, example 4 and comparative examples 1 to 6. Wherein, the average concentration 1 and the average concentration 2 refer to the average of the IL-1 alpha concentration in three duplicate wells of each of the two replicates, respectively.
The test results are shown in table 3 below and fig. 2.
TABLE 3 IL-1. alpha. content
| Group of | IL-1. alpha. average concentration 1(pg/ml) | IL-1. alpha. average concentration 2(pg/ml) |
| Blank control | 15.20 | 13.53 |
| Negative control | 86.42 | 85.69 |
| Positive control (dexamethasone) | 12.59 | 11.72 |
| Example 2 | 43.68 | 42.73 |
| Example 4 | 28.63 | 29.34 |
| Comparative example 1 | 56.84 | 53.86 |
| Comparative example 2 | 75.59 | 76.53 |
| Comparative example 3 | 73.41 | 72.82 |
| Comparative example 4 | 50.38 | 51.67 |
| Comparative example 5 | 66.26 | 63.84 |
| Comparative example 6 | 83.56 | 84.05 |
Based on table 3 and fig. 1, experimental results show that examples 2 and 4 and comparative examples 1 and 4 have better inhibition effect on the inflammatory factor IL-1 α, but the results of examples 1 and 4 are better than those of comparative examples 1 and 4, which shows that the raw material components have synergistic effect after being mixed, and the inhibition effect of a single raw material on the inflammatory factor IL-1 α can be greatly improved.
3. Anti-allergy relief efficacy test
The test samples are the essences obtained in example 2, example 3 and comparative examples 1-6
The test method comprises the following steps: 80 skin care products with good health condition, age of 18-55 years, dry and sensitive desert skin self-evaluated by questionnaires, randomly divided into 8 groups, 6 persons in each group, respectively used for the essence of the examples and the comparative examples, after cleaning the face in the morning and evening, about 1g of the test sample is taken, tapped on the face until being absorbed, used once in the morning and evening, and continuously used for 28 days, and other skin care products or products with similar effects are not used in the period.
3.1 skin transdermal Water loss test
The skin moisture content of the subjects before and after use was measured and recorded at D0, D14 and D28, respectively, and the skin moisture content was measured by a Tewameter TM 300; skin permeability barrier function is indirectly reflected by epidermal water loss, and sensitive skin often shows an increase in this data. The TEWL parameter is compared with the moisture loss condition of the skin before and after the product is used, and the lower the measured value is, the lower the moisture loss of the skin at the tested part through the epidermis is, the better the indirect reaction epidermal permeability barrier function is, and the stronger the barrier repair capability of the product is.
The test results are shown in table 4 below and fig. 2.
TABLE 4 test results of skin transdermal water loss values
As can be seen from table 4 and fig. 2, the soothing and repairing essences prepared in examples 2 and 3 have a good effect on skin barrier repair, and have a better barrier repair effect than the essences prepared from the individual components of the comparative examples.
3.2 skin hemoglobin content test
The skin hemoglobin content of the test subject before and after the product application was measured and recorded at D0, D14 and D28, respectively, and the smaller the skin hemoglobin content measured by MexameterMX18, the lower the skin hemoglobin content, indicating that the skin redness was relieved.
The test results are shown in table 5 below and fig. 3.
TABLE 5 results of skin hemoglobin content test
From table 5 and fig. 3, it can be seen that the soothing and rejuvenating essences of example 2 and example 3 have better effects on relieving redness, and are superior to the essences of comparative examples 1 to 6 in result. And imaging is performed through Visia CR instrument test, and as seen from fig. 4, after 28 days of using the soothing and repairing essence of example 3, the skin red area range is reduced, and the red color becomes lighter, which shows that the sensitivity of the skin is improved, and the barrier function is well repaired.
3.3 somatosensory evaluation
The results of the user's soothing repair after 28 days of use for examples 2 and 3 and comparative examples 4 to 6 described above were evaluated, and the evaluation results are shown in Table 6.
TABLE 6 usage evaluation Table
From the above test results, it can be seen that the overall soothing and repairing effects of examples 2 and 3 are far superior to those of the comparative example.
Therefore, the soothing and repairing composition prepared by compounding the scutellaria alpina extract, the panthenol and the bofenate spirulina extract according to a specific proportion is applied to a facial care product, and the prepared soothing and repairing essence has a good soothing and repairing effect on dry desert skin.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily think of the changes or substitutions within the technical scope of the present invention, and shall cover the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (9)
1. A soothing and repairing composition suitable for dry skin in desert is characterized by comprising the following components: scutellariae radix extract, panthenol and Bonnate Spirulina extract.
2. A soothing and repairing composition for dry desert skin as claimed in claim 1, which comprises the following components in parts by weight: 0.1-5 parts of scutellaria alpina extract, 0.1-10 parts of panthenol and 0.1-5 parts of bofenate spirulina extract.
3. A soothing and repairing composition for dry desert skin as claimed in claim 2, which comprises the following components in parts by weight: 0.3-4 parts of scutellaria alpina extract, 0.3-5 parts of panthenol and 0.2-3 parts of bofenate spirulina extract.
4. A soothing repairing composition suitable for dry desert skin as claimed in claim 3, wherein the composition comprises the following components in parts by weight: 0.5-3 parts of scutellaria alpina extract, 0.5-3 parts of panthenol and 0.3-1 part of bofenate spirulina extract.
5. Use of a soothing rejuvenating composition according to any one of claims 1 to 4 for dry desert skin, in the preparation of cosmetics, including lotions, serums, lotions, creams, masks, sun screens, cleansing products.
6. A soothing and repairing essence, characterized by comprising, by mass, 0.6% -20% of a soothing and repairing composition as defined in any one of claims 1-4, 5% -20% of a polyhydric alcohol, 0.01% -0.05% of a chelating agent, 0.01-0.5% of a pH regulator, 0.1% -1% of a preservative, 0.1-0.5% of a thickener, and the balance to 100% of a solvent, wherein the solvent is at least one of deionized water, distilled water, ion exchange water, double distilled water, high purity water and purified water.
7. A soothing repair serum as claimed in claim 6 wherein the polyhydric alcohol is selected from at least one of glycerol, 1, 3-propanediol, butanediol, dipropylene glycol, 1, 2-pentanediol, sorbitol, erythritol; the thickener is at least one of carbomer, xanthan gum, hydroxyethyl cellulose, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and sodium polyacrylate.
8. A soothing repair serum as claimed in claim 6 wherein the chelating agent is disodium EDTA; the pH regulator is at least one of aminomethyl propanol, triethanolamine and arginine; the preservative is at least one of p-1, 2-hexanediol, hydroxyacetophenone, phenoxyethanol, methylparaben and caprylyl hydroximic acid.
9. The soothing repair essence of claim 6, consisting of the following components in percentage by mass: 0.05% of EDTA disodium, 0.05% of xanthan gum, 0.15% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 5% of butanediol, 2% of glycerol, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of arginine and 2% of Scutellaria alpina extract; 2% of panthenol, 0.8% of Botani spirulina extract and the balance of deionized water to 100%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115569106A (en) * | 2022-09-09 | 2023-01-06 | 广州市科能化妆品科研有限公司 | Water extract of spirulina H11 strain, preparation method and application thereof, and skin care product |
| CN115737478A (en) * | 2023-01-09 | 2023-03-07 | 广州市科能化妆品科研有限公司 | Application of desert algae skin care raw material in preparation of skin soothing agent |
| CN115944576A (en) * | 2022-11-21 | 2023-04-11 | 烟台新时代健康产业日化有限公司 | Composition for repairing sensitive skin, mask liquid and mask |
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| CN115737478B (en) * | 2023-01-09 | 2023-06-02 | 广州市科能化妆品科研有限公司 | Application of desert algae skin care raw material in preparation of skin soothing agent |
| CN118436581A (en) * | 2024-05-07 | 2024-08-06 | 广州医药研究总院有限公司 | Anti-inflammatory and soothing composition and application thereof |
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Application publication date: 20220819 |