CN114931530B - Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof - Google Patents
Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof Download PDFInfo
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- CN114931530B CN114931530B CN202210288983.8A CN202210288983A CN114931530B CN 114931530 B CN114931530 B CN 114931530B CN 202210288983 A CN202210288983 A CN 202210288983A CN 114931530 B CN114931530 B CN 114931530B
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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Abstract
A skin care composition with anti-sensitization and repair effects, application, cosmetics and a method thereof relate to the technical field of skin care products; comprises the following components in parts by mass: 0.5-5 parts of blue copper peptide, 0.1-5 parts of palmitoyl tripeptide-8, 0.3-5 parts of carnosine, 0.1-5 parts of hydrogenated lecithin, 1-5 parts of a fermentation product of saccharomyces cerevisiae, 1-5 parts of asiaticoside, 2-7 parts of baicalin, 5-15 parts of prinsepia utilis royle seed extract, 2-10 parts of lithospermum extract, 1-10 parts of perilla extract, 1-10 parts of purslane extract and 1-7 parts of rabdosia lophanthide extract. The invention prevents histamine from releasing, repairs skin barrier, resists oxidation, removes free radical, improves skin through various actions, and improves anti-inflammatory and allergy-relieving effects through the synergistic action of the components.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a skin care composition with anti-sensitization and repair effects, an application thereof, a cosmetic and a method thereof.
Background
Skin allergy and irritation refer to abnormal immune responses, mainly including physiological dysfunction or tissue cell injury, when the body is stimulated by certain antigens, and the abnormal immune responses are mainly classified into allergic contact dermatitis and irritant contact dermatitis.
At present, the cosmetic has the following ways for preventing and treating skin sensitivity and irritation: 1. inhibiting inflammatory mediator release such as histamine; 2. enhancing body barrier function; 3. scavenging excessive free radical in vivo. Dermatitis is caused by inflammation mediators such as histamine, which is formed by decarboxylation of histidine in vivo, and the histamine in tissues exists in granules of mast cells and basophils in inactive combination, and is contained in a large amount in skin, bronchial mucosa, intestinal mucosa and nervous system. When the organism is subjected to physical and chemical stimulation or anaphylactic reaction, the cells can be caused to be degranulated, so that histamine is released and combined with histamine receptors to generate biological effects; the antihistamine can inhibit the mast cells from releasing allergic substances such as histamine and the like and inhibit the division of eosinophils and mast cells, thereby preventing the aggregation of the cells at an inflammation position, relieving inflammatory reaction and achieving the treatment purpose. Studies have shown that abnormalities in the lipid barrier not only reduce the water storage and moisturization functions of the skin, but also directly affect the regulation of keratinocyte growth and differentiation, affecting the formation of healthy stratum corneum, which is the core of the physical barrier structure of the skin, and repairing or enhancing the barrier function of the skin is an effective way to reduce skin sensitivity. Free radicals in humans destroy cell membranes, inactivate serum antiproteases, and damage genes leading to the appearance and accumulation of cellular variation. The attack of free radicals on the human body begins with the cell membrane. The cell membrane is extremely elastic and flexible, which is determined by its loose chemical structure, and as such, its electrons are easily lost, and thus the cell membrane is extremely vulnerable to free radical attack. Once electrons are taken away by the free radicals, the cell membrane loses elasticity and loses all functions, resulting in cardiovascular diseases. More serious is the attack of free radical on gene, which can destroy the molecular structure of gene and result in mutation of gene, resulting in systematic confusion of whole life. The excellent anti-allergic skin care product can inhibit the release of histamine, can penetrate into cells to fundamentally block allergic reaction, can effectively remove free radicals, and can protect cell membranes from being damaged by the free radicals.
Most of the existing cosmetics for relieving and resisting allergy are used for relieving the symptoms such as burning, stinging, itching and tightness of skin from the aspect of inhibiting histamine, and the products can relieve the symptoms of skin allergy in a short period of time, but are easy to repeatedly attack and cannot effectively improve the skin quality.
Disclosure of Invention
In order to overcome the defects in the prior art, one of the purposes of the invention is to provide a skin care composition with anti-allergic and repairing effects, which has the effects of anti-inflammatory and allergy relieving, skin barrier repairing, anti-oxidation and free radical removing.
It is a second object of the present invention to provide the use of the above skin care composition with anti-sensitization and restoration effects.
The invention further aims to provide a cosmetic with anti-allergic and repairing effects, which can effectively reduce the irritation of exogenous factors to skin, has the effects of relieving allergic symptoms, repairing skin barriers, resisting oxidization and removing free radicals, has good permeability and moisturizing effect, supplements nutrients for the skin and promotes metabolism of cells.
The fourth object of the present invention is to provide a method for preparing cosmetics with anti-sensitization and repairing effects.
One of the purposes of the invention is realized by adopting the following technical scheme:
a skin care composition with anti-allergy and repairing effects comprises the following components in parts by mass:
0.5-5 parts of blue copper peptide, 0.1-5 parts of palmitoyl tripeptide-8, 0.3-5 parts of carnosine, 0.1-5 parts of hydrogenated lecithin, 1-5 parts of a fermentation product of saccharomyces cerevisiae, 1-5 parts of asiaticoside, 2-7 parts of baicalin, 5-15 parts of prinsepia utilis royle seed extract, 2-10 parts of lithospermum extract, 1-10 parts of perilla extract, 1-10 parts of purslane extract and 1-7 parts of rabdosia lophanthide extract.
Further, the composition comprises the following components in parts by mass:
1-3 parts of blue copper peptide, 0.5-2 parts of palmitoyl tripeptide-8, 0.8-2 parts of carnosine, 0.5-3 parts of hydrogenated lecithin, 2-4 parts of a fermentation product of schizosaccharomyces, 2-4 parts of asiaticoside, 3-5 parts of baicalin, 7-12 parts of a prinsepia utilis royle seed extract, 3-8 parts of a lithospermum extract, 2-6 parts of a perilla extract, 2-6 parts of a purslane extract and 1-4 parts of a rabdosia lophance extract.
Further, the mass ratio of the blue copper peptide to the palmitoyl tripeptide to the carnosine is 0.8-2:0.5-1.2:1.
Further, the hydrogenated lecithin is derived from soybean; the asiaticoside is derived from centella asiatica; the baicalin is derived from radix Scutellariae.
The second purpose of the invention is realized by adopting the following technical scheme:
a skin care composition with antiallergic and repairing effects is used for preparing cosmetics.
The third purpose of the invention is realized by adopting the following technical scheme:
a cosmetic with anti-sensitization and restoration effects is applied to the skin care composition with the anti-sensitization and restoration effects, and comprises the following components in parts by mass:
10-30 parts of skin care composition, 0.1-5 parts of allantoin, 0.1-5 parts of panthenol, 0.01-0.2 part of sodium hyaluronate, 1-10 parts of humectant, 1-3 parts of emulsifier, 0.5-2 parts of thickener, 0.1-1 part of chelating agent, 0.1-0.5 part of pH regulator and 40-70 parts of water.
Further, the humectant is prinsepia utilis royle oil, glycerol, propylene glycol and 1, 2-pentanediol with the mass ratio of 1-2:1-2:0.5-1.5:1;
the emulsifier is cetyl stearyl alcohol and/or cetostearyl glucoside;
the thickener is carbomer and/or behenyl alcohol;
the chelating agent is disodium EDTA;
the pH regulator is triethanolamine.
Further, 0.01 to 0.03 part of preservative is also included; wherein the preservative is p-hydroxyacetophenone and/or propyl hydroxybenzoate.
The fourth purpose of the invention is realized by adopting the following technical scheme:
a preparation method of a cosmetic with antiallergic and repairing effects comprises the following steps:
s1, mixing allantoin, panthenol, sodium hyaluronate, a humectant, an emulsifier, a thickener and water, heating and uniformly stirring to obtain a mixed solution A;
s2, cooling the mixed solution A, adding the skin care composition and the chelating agent, and uniformly stirring to obtain a mixed solution B;
and S3, adding a pH regulator into the mixed solution B, and uniformly stirring to obtain the cosmetic with anti-allergy and repairing effects.
Further, in the step S1, the heating temperature is 65-80 ℃;
in the step S2, the temperature of the cooling is 35-45 ℃.
Compared with the prior art, the invention has the beneficial effects that:
the skin care composition with the antiallergic and repairing effects adopts the combination of the blue copper peptide, the palmitoyl tripeptide-8 and the carnosine as active peptide components, so that the antiallergic and anti-inflammatory effects are improved. Wherein, the blue copper peptide can strengthen the water retention capacity of skin, repair and regeneration of damaged skin, tighten skin, reduce fine wrinkles, and have the functions of resisting allergy and diminishing inflammation; palmitoyl tripeptide-8 has high specific anti-inflammatory activity, inhibits inflammatory reaction, reduces the release of pro-inflammatory factors, comprises 1L-1,1L-8, reduces vascular expansion and permeability, and effectively prevents and reduces inflammation caused by exogenous stimulation; carnosine has the functions of resisting oxidation and removing free radicals, and is favorable for repairing skin. The addition of hydrogenated lecithin can promote the percutaneous absorption of the skin care composition; the fermentation product of the saccharomyces cerevisiae can repair skin barrier, increase skin elasticity, prevent skin aging and keep moisture for a long time; the asiaticoside has remarkable anti-inflammatory and allergy relieving effects, has remarkable antioxidant and free radical removing effects, and can be used for regulating immune system; baicalin can inhibit histamine production, and has outstanding anti-inflammatory effect; prinsepia utilis royle seed extract has effects of nourishing skin, resisting bacteria, diminishing inflammation, promoting blood circulation and removing blood stasis; the lithospermum extract, the perilla extract, the purslane extract and the rabdosia lophanthide extract are used as traditional Chinese medicine components, and have excellent anti-inflammatory and anti-allergic effects; meanwhile, the purslane extract and the rabdosia lophanthide extract have outstanding antibacterial performance, so that the use amount of preservative in the skin care composition can be reduced, and the irritation to skin is reduced. The invention prevents histamine from releasing, repairs skin barrier, resists oxidation, removes free radical, improves skin through various actions, and improves anti-inflammatory and allergy-relieving effects through the synergistic action of the components.
The application of the skin care composition with the anti-sensitization and repair effects in the preparation of cosmetics enables the cosmetics to have the anti-sensitization and repair effects.
The cosmetic with the anti-allergic and repairing effects is added with the allantoin, panthenol, sodium hyaluronate and other effective components, can deeply permeate the skin, has the moisturizing effect, stimulates the growth of epithelial cells, promotes the repair of skin barrier damage, effectively reduces the stimulation of exogenous factors to the skin, and has the effects of relieving allergic symptoms, repairing skin barriers, resisting oxidation and removing free radicals, supplementing nutrient components for the skin and promoting the metabolism of cells.
The preparation method of the cosmetic with the anti-allergy and repairing effects is simple, easy to operate and applicable to mass production.
Detailed Description
The present invention will be further described with reference to the following specific embodiments, and it should be noted that, on the premise of no conflict, new embodiments may be formed by any combination of the embodiments or technical features described below.
Unless otherwise specified, the reagents and materials used in the present invention are either commercially available or are extracted from plants by conventional means.
Skin care compositions of examples 1-5 having anti-sensitization and restoration effects were composed as shown in Table 1.
TABLE 1
| Component (A) | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| Blue copper peptide | 0.5 | 1 | 2 | 3 | 5 |
| Palmitoyl tripeptide-8 | 0.1 | 0.5 | 1.5 | 2 | 5 |
| Carnosine (carnosine) | 0.3 | 0.8 | 1.2 | 2 | 5 |
| Hydrogenated lecithin | 0.1 | 0.5 | 1 | 3 | 5 |
| Fermentation product of Saccharomyces cerevisiae | 5 | 4 | 3 | 2 | 1 |
| Asiaticoside | 5 | 4 | 3 | 2 | 1 |
| Baicalin | 7 | 5 | 3 | 3 | 2 |
| Prinsepia utilis royle seed extract | 15 | 12 | 10 | 8 | 5 |
| Lithospermum erythrorhizon extract | 10 | 8 | 5 | 3 | 2 |
| Perilla extract | 10 | 6 | 4 | 2 | 1 |
| Purslane extract | 10 | 6 | 4 | 2 | 1 |
| Rabdosia lophanthide extract | 7 | 4 | 3 | 1 | 1 |
Example 6
A cosmetic with anti-sensitization and restoration effect, which is applied with the skin care composition with anti-sensitization and restoration effect described in the example 2, comprises the following components in parts by mass:
15 parts of skin care composition, 0.1 part of allantoin, 0.1 part of panthenol, 0.01 part of sodium hyaluronate, 1 part of humectant, 1 part of emulsifier, 0.5 part of thickener, 0.1 part of chelating agent, 0.1 part of pH regulator, 40 parts of water and 0.01 part of preservative.
Further, the humectant is prepared from the following components in percentage by mass: prinsepia utilis royle oil, glycerol, propylene glycol and 1, 2-pentanediol in a ratio of 1:0.5:1;
the emulsifier is cetostearyl alcohol;
the thickener is carbomer;
the chelating agent is disodium EDTA;
the pH regulator is triethanolamine.
The preservative is p-hydroxyacetophenone.
A preparation method of a cosmetic with antiallergic and repairing effects comprises the following steps:
1) Adding the formula amount of blue copper peptide, palmitoyl tripeptide-8, carnosine, hydrogenated lecithin, a fermentation product of the two-split yeast, asiaticoside, baicalin, lithospermum extract, perilla extract, purslane extract and rabdosia lophanthide extract into a proper amount of propylene glycol-water solution at 40 ℃ and stirring uniformly to obtain a skin care composition mixed solution; wherein, the volume percentage of the propylene glycol in the propylene glycol-water solution is 10 percent, and the stirring speed is 80rpm;
2) Mixing allantoin, panthenol, sodium hyaluronate, a humectant, an emulsifier, a thickener and water, heating and uniformly stirring to obtain a mixed solution A; the heating temperature is 70 ℃, and the stirring speed is 120rpm;
3) Cooling the mixed solution A, adding the skin care composition mixed solution and the chelating agent, and uniformly stirring to obtain a mixed solution B; the stirring rate was 60rpm;
4) Adding a pH regulator into the mixed solution B and uniformly stirring to obtain a cosmetic with anti-sensitization and repairing effects; the temperature of the cooling is 35 ℃, and the stirring speed is 40rpm.
Example 7
A cosmetic with anti-sensitization and restoration effect, which is applied with the skin care composition with anti-sensitization and restoration effect described in the embodiment 3, comprises the following components in parts by mass:
20 parts of skin care composition, 3 parts of allantoin, 2 parts of panthenol, 0.1 part of sodium hyaluronate, 5 parts of humectant, 2 parts of emulsifier, 1 part of thickener, 0.5 part of chelating agent, 0.3 part of pH regulator and 55 parts of water.
Further, the humectant has a mass ratio of 1.5: prinsepia utilis royle oil, glycerol, propylene glycol and 1, 2-pentanediol in a ratio of 1:1:1;
the emulsifier is cetylstearyl glucoside;
the thickening agent is behenyl alcohol;
the chelating agent is disodium EDTA;
the pH regulator is triethanolamine.
A preparation method of a cosmetic with antiallergic and repairing effects comprises the following steps:
1) Adding the formula amount of blue copper peptide, palmitoyl tripeptide-8, carnosine, hydrogenated lecithin, a fermentation product of the two-split yeast, asiaticoside, baicalin, lithospermum extract, perilla extract, purslane extract and rabdosia lophanthide extract into a proper amount of propylene glycol-water solution at 40 ℃ and stirring uniformly to obtain a skin care composition mixed solution; wherein, the volume percentage of the propylene glycol in the propylene glycol-water solution is 10 percent, and the stirring speed is 80rpm;
2) Mixing allantoin, panthenol, sodium hyaluronate, a humectant, an emulsifier, a thickener and water, heating and uniformly stirring to obtain a mixed solution A; the heating temperature is 75 ℃, and the stirring speed is 110rpm;
3) Cooling the mixed solution A, adding the skin care composition mixed solution and the chelating agent, and uniformly stirring to obtain a mixed solution B; the stirring rate was 60rpm;
4) Adding a pH regulator into the mixed solution B and uniformly stirring to obtain a cosmetic with anti-sensitization and repairing effects; the temperature of the cooling is 40 ℃, and the stirring speed is 40rpm.
Example 8
A cosmetic with anti-sensitization and restoration effect, which is applied with the skin care composition with anti-sensitization and restoration effect described in the example 4, comprises the following components in parts by mass:
25 parts of skin care composition, 5 parts of allantoin, 5 parts of panthenol, 0.2 part of sodium hyaluronate, 10 parts of humectant, 3 parts of emulsifier, 2 parts of thickener, 1 part of chelating agent, 0.5 part of pH regulator, 70 parts of water and 0.03 part of preservative.
Further, the humectant comprises the following components in percentage by mass: 2:1.5:1 prinsepia utilis royle oil, glycerol, propylene glycol and 1, 2-pentanediol;
the emulsifier is cetostearyl alcohol;
the thickener is carbomer;
the chelating agent is disodium EDTA;
the pH regulator is triethanolamine.
The preservative is propyl hydroxybenzoate.
A preparation method of a cosmetic with antiallergic and repairing effects comprises the following steps:
1) Adding the formula amount of blue copper peptide, palmitoyl tripeptide-8, carnosine, hydrogenated lecithin, a fermentation product of the two-split yeast, asiaticoside, baicalin, lithospermum extract, perilla extract, purslane extract and rabdosia lophanthide extract into a proper amount of propylene glycol-water solution at 40 ℃ and stirring uniformly to obtain a skin care composition mixed solution; wherein, the volume percentage of the propylene glycol in the propylene glycol-water solution is 10 percent, and the stirring speed is 80rpm;
2) Mixing allantoin, panthenol, sodium hyaluronate, a humectant, an emulsifier, a thickener and water, heating and uniformly stirring to obtain a mixed solution A; the heating temperature is 80 ℃, and the stirring speed is 100rpm;
3) Cooling the mixed solution A, adding the skin care composition mixed solution and the chelating agent, and uniformly stirring to obtain a mixed solution B; the stirring rate was 50rpm;
4) Adding a pH regulator into the mixed solution B and uniformly stirring to obtain a cosmetic with anti-sensitization and repairing effects; the temperature of the cooling is 45 ℃, and the stirring speed is 30rpm.
Skin care compositions of comparative examples 1-6, the components of which are shown in Table 2.
TABLE 2
Performance testing
1. DPPH radical scavenging test
The experimental method comprises the following steps: samples of examples 1 to 8 and comparative examples 1 to 6 were dissolved in a mixed solution of glycerin and water at a water volume ratio of 1:5 to prepare sample solutions, respectively, in which the mass concentration of the samples was 0.5%.
Test A20 mmol/L DPPH solution was prepared according to the method specified in Larrauri JA.
2.0mL of the sample solution and 2.0mL of the 20mmol/LDPPH solution were mixed and reacted for 30min, and the absorbance was measured at 517 nm. DPPH inhibition was calculated from the absorbance values and the results are shown in Table 3.
2. Test for inhibition of histamine release
Peripheral blood basophils (KU 812) are often used as effector cells for studying allergic reactions, and the present invention uses a KU812 cell histamine release model to examine the effect of samples on KU812 cell pro-inflammatory cytokine expression.
Cell model establishment: cell density was adjusted to 2X 10 by diluting cells with IMDM medium containing 10% fetal bovine serum 6 The resulting cell suspension was then seeded into well plates at an inoculum size of 150 μl per well.
Preparing and treating a tested sample: sample solutions of examples 1-8 and comparative examples 1-6 were formulated in DMSO at a mass concentration of 10% skin care composition, and then diluted to a skin care composition concentration of 0.3% by 10% fetal bovine serum culture medium to give test solutions.
The cell suspension was incubated at 36℃with 5% CO 2 Culturing in incubator for 10min, adding 20 μl of test solution, respectively, providing a control group without test solution, pre-incubating in incubator for 2 hr, adding stimulator (40 nM crotyl alcohol-12-tetradecanoate-13-acetate (PMA), 1 μm calcium ionophore A2318, respectively7) The PMA and a23187 were formulated using DMSO; after 2h, the cells were centrifuged, the cell supernatant was collected, and the histamine content in the supernatant was measured. The experimental results are shown in table 3.
3. Skin moisturization test
The skin care compositions of examples 1 to 5 and comparative examples 1 to 6 were diluted in a mixed solvent of glycerin and water in a volume ratio of 1:5 to a skin care composition mass concentration of 1%, to prepare sample solutions; sample solutions were prepared by diluting the cosmetics of examples 6 to 8 20 times. A supersaturated solution of ammonium sulfate was placed in a sealed container desiccator, the relative humidity of air was maintained at 60%, a medical breathable tape was attached to the slide, the tape was 6 cm. Times.2 cm, and 100. Mu.L of the test substance was applied to the tape. The control group was deionized water and 3 replicates were made per sample. Placing for 4 hours in a 40% humidity environment, weighing and calculating the moisture retention rate; the experimental results are shown in table 3.
4. Test of Water percutaneous loss
The principle of the transdermal moisture loss test is to measure the change in vapor pressure of moisture adjacent to the skin surface based on the diffusion principle. A cylindrical cavity measuring probe with two open ends is specially designed to form a relatively stable test small environment on the skin surface, the water vapor pressure gradient of the near epidermis (within about 1 cm) formed by the water loss of the stratum corneum at different two points is measured through two groups of temperature and humidity sensors, and the water amount evaporated through the epidermis is directly measured, so that the water loss condition of the skin surface is measured, and the moisturizing and skin barrier repairing effects of cosmetics on the skin surface can be evaluated. The calculation formula of the relative value of TEWL is:
TEWL relative value= (skin moisture loss of test sample-skin moisture loss of blank)/(skin moisture loss of positive control-skin moisture loss of blank).
The experimental method comprises the following steps: 36 healthy subjects 20-40 years old were selected and divided into 13 groups, none of the subjects had a history of skin disease, the tested sites were normal, and no experiment-independent medicines or cosmetics were applied during the test. The temperature of the test environment is controlled at 25+/-1 ℃, the relative humidity is 40+/-5%, purified water at 36 ℃ is used for wiping the two arms of the subject before the test, and the subject is allowed to sit still for 30min in the test environment for the test.
Sample solution: the skin care compositions of examples 1 to 5 and comparative examples 1 to 6 were diluted in a mixed solvent of glycerin and water in a volume ratio of 1:5 to a skin care composition mass concentration of 1%, to prepare sample solutions; sample solutions were prepared by diluting the cosmetics of examples 6 to 8 20 times; the positive control was sodium hyaluronate solution at the same concentration, and a blank control was set. Marking a plurality of regions on each subject's arm, the regions being generally 5X 5cm in size 2 . And coating the tested sample, blank control and positive control sample on different areas of the arm of the same subject. The skin moisture loss in the test area was measured 3 hours after application by a skin moisture loss tester, the relative value of TEWL was calculated, and the experimental results are shown in table 3.
TABLE 3 Table 3
As shown in Table 3, the skin care composition with anti-allergic and repairing effects of the present invention prevents histamine release, repairs skin barrier, resists oxidation, removes free radical, improves skin through various effects, and improves anti-inflammatory and allergy-relieving effects through synergistic effects of the components. The cosmetics in examples 6 to 8 have insignificant effects in a short period of time due to the low concentration of the skin care composition, but can continuously supplement nutrients to the skin by compounding various raw materials having good permeability and moisturizing effects, and are more suitable for long-term use, free from irritation, repair and improvement of skin, and increase of skin immunity.
The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present invention are intended to be within the scope of the present invention as claimed.
Claims (7)
1. A cosmetic with anti-allergy and repairing effects is characterized by comprising the following components in parts by mass:
10-30 parts of skin care composition, 0.1-5 parts of allantoin, 0.1-5 parts of panthenol, 0.01-0.2 part of sodium hyaluronate, 1-10 parts of humectant, 1-3 parts of emulsifier, 0.5-2 parts of thickener, 0.1-1 part of chelating agent, 0.1-0.5 part of pH regulator and 40-70 parts of water;
the skin care composition comprises the following components in parts by mass:
0.5-5 parts of blue copper peptide, 0.1-5 parts of palmitoyl tripeptide-8, 0.3-5 parts of carnosine, 0.1-5 parts of hydrogenated lecithin, 1-5 parts of a fermentation product of schizosaccharomyces, 1-5 parts of asiaticoside, 2-7 parts of baicalin, 5-15 parts of prinsepia utilis royle seed extract, 2-10 parts of lithospermum extract, 1-10 parts of perilla extract, 1-10 parts of purslane extract and 1-7 parts of rabdosia lophanthide extract;
the mass ratio of the blue copper peptide to the palmitoyl tripeptide to the carnosine is 2:1.5:1.2.
2. the cosmetic with anti-allergic and repairing effects according to claim 1, comprising the following components in parts by mass:
1-3 parts of blue copper peptide, 0.5-2 parts of palmitoyl tripeptide-8, 0.8-2 parts of carnosine, 0.5-3 parts of hydrogenated lecithin, 2-4 parts of a fermentation product of schizosaccharomyces, 2-4 parts of asiaticoside, 3-5 parts of baicalin, 7-12 parts of a prinsepia utilis royle seed extract, 3-8 parts of a lithospermum extract, 2-6 parts of a perilla extract, 2-6 parts of a purslane extract and 1-4 parts of a rabdosia lophance extract.
3. The cosmetic having antiallergic and restorative action according to claim 1, wherein said hydrogenated lecithin is derived from soybean; the asiaticoside is derived from centella asiatica; the baicalin is derived from radix Scutellariae.
4. The cosmetic with anti-allergic and repairing effects according to claim 1, wherein the humectant is prinsepia utilis royle oil, glycerol, propylene glycol and 1, 2-pentanediol in a mass ratio of 1-2:1-2:0.5-1.5:1;
the emulsifier is cetyl stearyl alcohol and/or cetostearyl glucoside;
the thickener is carbomer and/or behenyl alcohol;
the chelating agent is disodium EDTA;
the pH regulator is triethanolamine.
5. The cosmetic having an antiallergic and restorative action according to claim 1, further comprising 0.01 to 0.03 parts of a preservative; wherein the preservative is p-hydroxyacetophenone and/or propyl hydroxybenzoate.
6. A method for preparing a cosmetic having antiallergic and restorative effects as set forth in claim 1, characterized in that: the method comprises the following steps:
s1, mixing allantoin, panthenol, sodium hyaluronate, a humectant, an emulsifier, a thickener and water, heating and uniformly stirring to obtain a mixed solution A;
s2, cooling the mixed solution A, adding the skin care composition and the chelating agent, and uniformly stirring to obtain a mixed solution B;
and S3, adding a pH regulator into the mixed solution B, and uniformly stirring to obtain the cosmetic with anti-allergy and repairing effects.
7. The method for preparing a cosmetic having antiallergic and restorative effects as set forth in claim 6, characterized in that: in the step S1, the heating temperature is 65-80 ℃;
in the step S2, the temperature of the cooling is 35-45 ℃.
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| CN115317396B (en) * | 2022-09-22 | 2024-01-19 | 广东丸美生物技术股份有限公司 | Blue copper peptide composition, preparation method thereof and cosmetics |
| CN115517997B (en) * | 2022-09-27 | 2024-01-23 | 浙江湃肽生物股份有限公司 | Cosmetic composition, and preparation method and application thereof |
| CN115590809A (en) * | 2022-10-20 | 2023-01-13 | 山东元裕生物科技有限公司（Cn） | Composition for repairing problem skin, preparation method and application |
| CN115554218A (en) * | 2022-11-01 | 2023-01-03 | 广州英凡妮生物科技有限公司 | Antioxidant and anti-sugar composition containing orchid extract and preparation method and application thereof |
| CN115944576A (en) * | 2022-11-21 | 2023-04-11 | 烟台新时代健康产业日化有限公司 | Composition for repairing sensitive skin, mask liquid and mask |
| CN116966127B (en) * | 2023-08-24 | 2024-02-13 | 广州西子化妆品科技有限公司 | Anti-allergy repair composition and preparation method and application thereof |
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