CN110237007A - A kind of cosmetic composition and its preparation method and application containing blue copper peptide - Google Patents
A kind of cosmetic composition and its preparation method and application containing blue copper peptide Download PDFInfo
- Publication number
- CN110237007A CN110237007A CN201910689597.8A CN201910689597A CN110237007A CN 110237007 A CN110237007 A CN 110237007A CN 201910689597 A CN201910689597 A CN 201910689597A CN 110237007 A CN110237007 A CN 110237007A
- Authority
- CN
- China
- Prior art keywords
- cosmetic composition
- blue copper
- copper peptide
- preparation
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of cosmetic composition and its preparation method and application containing blue copper peptide.The cosmetic composition is grouped as by the group of following parts by weight: blue copper peptide, purslane extract, VB5, Gotu Kola P.E.By blue copper peptide, purslane extract, the composition that VB5 and Gotu Kola P.E are mixed to get can play the antiallergic effect of releiving of each component, it is applied in cosmetics the dosage that can significantly reduce the chemical synthesis preparation with antiallergic effect of releiving, antiallergic of releiving effect is good, irritation is small, and also has the effect of anti-inflammatory, moisturizing and reparation.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of cosmetic composition and its preparation side containing blue copper peptide
Method and application.
Background technique
Due to heredity, environment, living habit, psychology, cosmetics improper use, abuse glucocorticoid, UV light exposure
Etc. the influence of factors and the phenomenon that leading to skin sensitivity it is more and more common.However, the mechanism of sensitive is still not clear,
Generally believe at present in mainly body with extraneous factor interact as a result, nerve impaired by skin barrier function passes
It leads function increase and immunoreactivity enhancing causes.Sensitive is often referred to oneself feel not to be resistant to be applied on skin
Any skin nursing products and cosmetics.In Dermatology, skin sensitivity problem is otherwise known as, and " cosmetics do not tolerate synthesis
Disease " is main to show as patient oneself and feel that face has shouting pain, burns, itching, tight or other discomforts；What skin had
Seem that the inflammation such as erythema, fash, rubescent, wheal show, then surface seems completely normal to some, only oneself feels have
Shouting pain is burnt, itching, the discomforts such as tight.In the crowd for thinking oneself skin sensitivity, often oneself feel and skin appearance
Performance it is inconsistent, the discomfort oneself felt will overweight the performance of real skin.
For these reasons, the present invention is specifically proposed.
Summary of the invention
In order to solve problem above of the existing technology, the present invention provides a kind of cosmetic combinations containing blue copper peptide
Object and its preparation method and application.
Specifically, the present invention provides a kind of cosmetic composition containing blue copper peptide, the group including following weight percentage
Point:
In an additional preferred embodiment, the present invention provides a kind of cosmetic compositions containing blue copper peptide, by following heavy
The group of amount percentage is grouped as:
In an additional preferred embodiment, the present invention provides a kind of cosmetic compositions containing blue copper peptide, by following heavy
The group of amount percentage is grouped as: blue copper peptide: 0.5%, purslane extract: 0.5%, Gotu Kola P.E: 0.5%, VB5:
0.5%, butanediol: 98%.
Preferably, the blue copper peptide is measured by high performance liquid chromatography (HPLC), and purity is greater than 99%.Blue copper peptide
Molecular structure it is as shown in Figure 1.
Preferably, the active material of the Gotu Kola P.E is selected from asiatic acid, asiaticosid, madacasso grass
One of glycosides, brahmic acid are a variety of.
Preferably, the asiatic acid is a kind of pentacyclic triterpenoid present in natural products.
Preferably, the polyalcohol is selected from glycerol, propylene glycol, butanediol, 1,2- pentanediol, 1,2- hexylene glycol, methyl
One of propylene glycol, pungent glycol and Sensiva SC50 are a variety of.
Preferably, the VB5 is the important precursor of coacetylase and acyl carrier protein biosynthesis, is general by ketone
Solve sour hydroxymethyl transferases, ketopantoate reductase, the four kinds of enzyme concerted catalysis of L-Aspartic acid-α-decarboxylase and pantothenate synthetase
Lower synthesis.
Preferably, the cosmetic composition form includes but is not limited to Essence, emulsion, creme, gel, dressing.
The present invention also provides a kind of preparation methods of cosmetic composition containing blue copper peptide, which is characterized in that including such as
Lower step:
(1) it is weighed respectively according to the weight percent of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is dissolved by heating, insulated and stirred, cooling down obtains mixing molten
Liquid A；
(3) mixed solution A is uniformly mixed with blue copper peptide, purslane extract and VB5, obtains the cosmetic combinations
Object.
Preferably, the blue copper peptide is synthesized using NCA technology, recrystallization technology, active ester technology, and HPLC purity is big
In 99%.
Preferably, the purslane extract uses solvent extraction method, ultrasonic wave assisted extraction method, microwave radiation exaraction
Method, enzyme extraction method, high-pressure pulse electric extraction method, homogenate/hot water extraction method.
Preferably, the extracting method of the asiaticosid and madecassoside has Orthogonal Method, circumfluence method, flash mentions
Method, supercritical ultrasonics technology.
Preferably, the temperature heated in the step of preparation method of the cosmetic composition containing blue copper peptide (2) is to 70-80
℃。
Preferably, insulated and stirred 5-10min in the step of preparation method of the cosmetic composition containing blue copper peptide (2), is stirred
Mixing rate is 60-80rpm.
Preferably, cooling temperature is 40-50 DEG C in the step of preparation method of the cosmetic composition containing blue copper peptide (2).
The present invention also provides application of the cosmetic composition containing blue copper peptide in the skin-protection product for preparing external preparation for skin.
Preferably, make-up composition of the invention has the effect of that highly effective and safe is releived antiallergic, can be used for rapid sedation and relaxes
Slow skin, enhances skin barrier, plays the role of anti-inflammatory, while can also play anti-acne, desalinates acne print, repairs impaired skin
Effect.
Compared with prior art, the invention has the benefit that
1. the present invention is using the synergistic effect of blue copper peptide, purslane extract, Gotu Kola P.E and VB5, so that this hair
Bright cosmetic composition has the effect of that highly effective and safe is releived antiallergic, can rapid sedation soothe the skin, enhance skin barrier,
Play the role of anti-inflammatory, while anti-acne can also be played, desalinate acne print, repairs the effect of impaired skin.
2. the blue copper peptide in the present invention is in addition to there is the effect for antiallergic of releiving, in terms of smoothing wrinkle, blue copper peptide can be daily
Minimum level is reduced in skin injury, and delaying aging phenomenon is a kind of crease-resistant reparation product of safe and non-stimulating anti-aging.
3. the preparation method of composition of the invention is safe and simple, can be mass produced.
Detailed description of the invention
Fig. 1 is the molecular structure of GHK-Cu tripeptides.
Fig. 2 is the right face skin condition figure of subject A before this cosmetic composition is not used.
Fig. 3 is the right face skin condition figure of subject A using after this cosmetic composition.
Fig. 4 is the result figure that embodiment 1 and comparative example 1 are applied to 1 and 2 regions of A experimenter.
Fig. 5 is the result figure that embodiment 5 and comparative example 2 are applied to 1 and 2 regions of B experimenter.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Beauty peptide is the polypeptide with certain cosmetology effect, is a kind of very popular cosmetic material.As one kind
Both effectiveness ingredient, beauty peptide mainly have anti-aging, crease-resistant, antiallergic is anti-inflammatory, moisturizing reparation, compact tender skin, it is sun-proof the effects of.Its kind
Class is various, and blue copper peptide is first cosmetics peptide active component truly, has in terms of antiallergic of releiving well
Effect.
Blue copper peptide (- 1 copper of tripeptides or GHK-Cu) is used as strong organization protection and antiphlogistic, protect wounded tissue from
Further damage issues signal for oxidation, shifts impaired protein and scar tissue, and is replaced with normal tissue, promotes macrophage
It is flowed into injury, release growth Ginza albumen hair follicle stimulating.Suitable for anti-inflammatory and reparation, promote wound healing, improves skin
Skin elasticity.
Rich in there is the chemical combination such as a large amount of flavonoids, adrenin, polysaccharide and various vitamins, amino acid in purslane
Object.In cosmetics: being mainly used for the various stimulations of antiallergy, anti-inflammatory anti-inflammatory and anti-outer bound pair skin, there are also anti-acne function
Energy.Especially there are apparent anti-allergic effects to the skin allergy that the generation of steroids cosmetics is used for a long time.
Terpenoid in Gotu Kola P.E is remarkably improved collagen and cellular layer fibronectin (fibronectin
Wide participation cell migration, stick, be proliferated, stopping blooding and the processes such as skin histology reparation) content, and can stimulate and facilitate scar
The production of the type i collagen of trace maturation, reduces the generation of inflammatory reaction.In addition, Gotu Kola P.E also can be reduced proinflammatory medium
The generation of (IL-1, MMP-1) improves and repairs skin itself barrier function.
VB5 most crucial skin-care effect is that reparation is anti-inflammatory.Reparation is for skin barrier, according to widely accepted
" brick mud structure " and newest barrier repair theory, the generation of lipid is most important to barrier is repaired between horn cell, and VB5 energy
Enough promote the generation of coacetylase, to have the function that reparation or enhancing skin barrier.
The present invention utilizes the synergistic effect of blue copper peptide, purslane extract, Gotu Kola P.E and VB5, so that of the invention
Composition have the effect of that highly effective and safe is releived antiallergic, can rapid sedation soothe the skin, enhance skin barrier, play anti-inflammatory
Effect, while anti-acne can also be played, desalinate acne print, repair the effect of impaired skin.
Case study on implementation 1
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 0.5g, purslane extract:
0.3g, Gotu Kola P.E: 0.8g, VB5:1g, butanediol: 5g, glycerol: 2g also include the following raw material: carbomer: 0.1g, pH
Regulator arginine: 0.08g, xanthan gum: 0.1g, water: 91g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, insulated and stirred, cooling down obtains
Mixed solution A；
(3) carbomer is dispersed with glycerol, xanthan gum then is added and water is heated to 80 DEG C, insulated and stirred 15min,
Stirring rate is 60rpm, adds mixed solution A, and cooling down obtains mixed solution B to 40 DEG C；
(4) mixed solution B is uniformly mixed with pH adjusting agent arginine, adds blue copper peptide, purslane extract and
VB5 obtains the implementation case product.
The more sensitive experimenter A of skin is found, the present embodiment product is first applied to the right face of subject A, observation uses
The variation of front and back.Shown in concrete outcome Fig. 2 and Fig. 3.Fig. 2 is to be not used before this cosmetic composition, the right face flesh of subject A
Skin situation.Fig. 3 is the right face skin condition of subject A using after this cosmetic composition.Two figures are compared it can be seen that making
With after this cosmetic composition, the skin inflammatory conditions of subject make moderate progress, and small pox is subsided, and skin polishes exquisiteness.
Case study on implementation 2
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 0.8g, purslane extract:
1g, Gotu Kola P.E: 1.5g, VB5:2g, butanediol: 8g, glycerol: 5g also include the following raw material: carbomer: 0.13g, pH
Regulator arginine: 0.104g, xanthan gum: 0.15g, water: 82g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, insulated and stirred, cooling down obtains
Mixed solution A；
(3) carbomer is dispersed with glycerol, xanthan gum then is added and water is heated to 80 DEG C, insulated and stirred 15min,
Stirring rate is 60rpm, adds mixed solution A, and cooling down obtains mixed solution B to 40 DEG C；
(4) mixed solution B is uniformly mixed with pH adjusting agent arginine, adds blue copper peptide, purslane extract and
VB5 obtains the implementation case product.
Case study on implementation 3
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 0.3g, purslane extract:
0.5g, Gotu Kola P.E: 1g, VB5:1.5g, butanediol: 6g, glycerol: 4g also include the following raw material: carbomer: 0.15g,
PH adjusting agent arginine: 0.12g, xanthan gum: 0.12g, water: 87g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, insulated and stirred, cooling down obtains
Mixed solution A；
(3) carbomer is dispersed with glycerol, xanthan gum then is added and water is heated to 80 DEG C, insulated and stirred 15min,
Stirring rate is 60rpm, adds mixed solution A, and cooling down obtains mixed solution B to 40 DEG C；
(4) mixed solution B is uniformly mixed with pH adjusting agent arginine, adds blue copper peptide, purslane extract and
VB5 obtains the implementation case product.
Case study on implementation 4
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 1g, purslane extract:
0.8g, Gotu Kola P.E: 1.3g, VB5:0.8g, butanediol: 7g, glycerol: 3g also include the following raw material: carbomer:
0.14g, pH adjusting agent arginine: 0.112g, xanthan gum: 0.8g, water: 86g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, insulated and stirred, cooling down obtains
Mixed solution A；
(3) carbomer is dispersed with glycerol, xanthan gum then is added and water is heated to 80 DEG C, insulated and stirred 15min,
Stirring rate is 60rpm, adds mixed solution A, and cooling down obtains mixed solution B to 40 DEG C；
(4) mixed solution B is uniformly mixed with pH adjusting agent arginine, adds blue copper peptide, purslane extract and
VB5 obtains the implementation case product.
Case study on implementation 5
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 0.6g, purslane extract:
0.6g, Gotu Kola P.E: 0.6g, VB5:1.3g, butanediol: 9g also include the following raw material: PEG-20 methyl times semihard
Resin acid ester: 0.5g, acryloyldimethyl ichthyodin/VP copolymer: 0.2g, caprylic/capric triglyceride: 1g, shea butter:
3g, water: 78g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, water, insulated and stirred is added after dissolution
Obtain mixing water phase A；
(3) PEG-20 methyl sesquistearate and shea butter are heated to 80 DEG C of dissolutions, add acryloyl
Dimethyl ichthyodin/VP copolymer and caprylic/capric triglyceride obtain miscella phase B, and then oily phase B is added again and mixes
Water phase A, insulated and stirred 15min, stirring rate 60rpm, then homogenization, homogeneous 7min, homogeneous rate are 3500rpm,
Cooling down obtains mixed emulsion C to 40 DEG C；
(4) blue copper peptide, purslane extract and VB5 are added in mixed emulsion C, obtains the implementation case product.
Case study on implementation 6
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 0.7g, purslane extract:
0.7g, Gotu Kola P.E: 0.7g, VB5:1.4g, butanediol: 10g also include the following raw material: PEG-20 methyl sesquialter
Stearate: the wooden fruit of 0.6g, acryloyldimethyl ichthyodin/VP copolymer: 0.25g, caprylic/capric triglyceride: 2g, cream
Oil: 4g, water: 80g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, water, insulated and stirred is added after dissolution
Obtain mixing water phase A；
(3) PEG-20 methyl sesquistearate and shea butter are heated to 80 DEG C of dissolutions, add acryloyl
Dimethyl ichthyodin/VP copolymer and caprylic/capric triglyceride obtain miscella phase B, and then oily phase B is added again and mixes
Water phase A, insulated and stirred 15min, stirring rate 60rpm, then homogenization, homogeneous 7min, homogeneous rate are 3500rpm,
Cooling down obtains mixed emulsion C to 40 DEG C；
(4) blue copper peptide, purslane extract and VB5 are added in mixed emulsion C, obtains the implementation case product.
Case study on implementation 7
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 0.9g, purslane extract:
0.9g, Gotu Kola P.E: 0.9g, VB5:1.6g, butanediol: 11g also include the following raw material: PEG-20 methyl sesquialter
Stearate: 0.7g, acryloyldimethyl ichthyodin/VP copolymer: 0.3g, caprylic/capric triglyceride: 3g, shea butter:
5g, water: 76g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, water, insulated and stirred is added after dissolution
Obtain mixing water phase A；
(3) PEG-20 methyl sesquistearate and shea butter are heated to 80 DEG C of dissolutions, add acryloyl
Dimethyl ichthyodin/VP copolymer and caprylic/capric triglyceride obtain miscella phase B, and then oily phase B is added again and mixes
Water phase A, insulated and stirred 15min, stirring rate 60rpm, then homogenization, homogeneous 7min, homogeneous rate are 3500rpm,
Cooling down obtains mixed emulsion C to 40 DEG C；
(4) blue copper peptide, purslane extract and VB5 are added in mixed emulsion C, obtains the implementation case product.
Case study on implementation 8
The present embodiment includes the blue copper peptide cosmetic composition in the present invention: blue copper peptide: 1.1g, purslane extract:
1.1g, Gotu Kola P.E: 1.1g, VB5:1.7g, butanediol: 12g also include the following raw material: PEG-20 methyl sesquialter
Stearate: the wooden fruit of 0.8g, acryloyldimethyl ichthyodin/VP copolymer: 0.35g, caprylic/capric triglyceride: 4g, cream
Oil: 6g, water: 72g.
The preparation method of cosmetic composition containing blue copper peptide described in the present embodiment, includes the following steps:
(1) it is weighed respectively according to the weight of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is heated to 80 DEG C of dissolutions, water, insulated and stirred is added after dissolution
Obtain mixing water phase A；
(3) PEG-20 methyl sesquistearate and shea butter are heated to 80 DEG C of dissolutions, add acryloyl
Dimethyl ichthyodin/VP copolymer and caprylic/capric triglyceride obtain miscella phase B, and then oily phase B is added again and mixes
Water phase A, insulated and stirred 15min, stirring rate 60rpm, then homogenization, homogeneous 7min, homogeneous rate are 3500rpm,
Cooling down obtains mixed emulsion C to 40 DEG C；
(4) blue copper peptide, purslane extract and VB5 are added in mixed emulsion C, obtains the implementation case product.
Comparative example 1
The composition of this comparative example forms are as follows: butanediol: 5g, glycerol: 2g, carbomer: 0.1g, arginine: 0.08g, Huang
Virgin rubber: 0.1g, water: 91g.Preparation method is same as Example 1.
Comparative example 2
The composition of this comparative example forms are as follows: butanediol: 9g, also includes the following raw material: PEG-20 methyl times semihard
Resin acid ester: 0.5g, acryloyldimethyl ichthyodin/VP copolymer: 0.2g, caprylic/capric triglyceride: 1g, shea butter:
3g, water: 78g.Preparation method is same as Example 5.
Two more sensitive experimenters of skin of B, C are found, first histamine solution is applied at the arm of patient, is being coated with histamine
Standardized of the region middle line of demarcation of solution, is divided into two regions, is set as 1 and 2.
Embodiment 1 and comparative example 1 are applied to 1 and 2 regions of A experimenter respectively, as a result such as Fig. 4.Again respectively by embodiment 5
1 and 2 regions of B experimenter are applied to comparative example 2, as a result such as Fig. 5.
The histamine tested above is a kind of itself long-living chemical substance, is transformed in vivo by histidine, with skin,
Content is more in tunica mucosa bronchiorum, intestinal mucosa and nervous system.It is present in mast cell and basophilic granulocyte particle, allergy
After primary stimuli basophilic granulocyte, mast cell degranulation, it can play and promote smooth muscle contraction, blood vessel dilatation, enhancing capillary
The effects such as permeability and mucous membrane glandular secretion, to just have the performance of dermatitis.
The antiallergic effect of releiving of product prepared by the product comparison ratio 1 as can be seen from Figure 4 prepared using the present embodiment 1
Fruit is good, likewise, releiving for product prepared by the product comparison ratio 4 as can be seen from Figure 5 prepared using the present embodiment 5 is anti-
Quick effect is good, illustrates have the antiallergic effect of releiving of the product of the addition present composition preferable.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of cosmetic composition containing blue copper peptide, which is characterized in that the component including following weight percentage:
2. a kind of cosmetic composition containing blue copper peptide, which is characterized in that be grouped as by the group of following weight percentage:
3. cosmetic composition according to claim 1, which is characterized in that the purity of the blue copper peptide is greater than 99%.
4. cosmetic composition according to claim 1, which is characterized in that the active material of the Gotu Kola P.E
Selected from one of asiatic acid, asiaticosid, madecassoside, brahmic acid or a variety of.
5. cosmetic composition according to claim 4, which is characterized in that the asiatic acid is deposited in natural products
A kind of pentacyclic triterpenoid.
6. cosmetic composition according to claim 1, which is characterized in that the polyalcohol be selected from glycerol, propylene glycol,
One of butanediol, 1,2- pentanediol, 1,2- hexylene glycol, methyl propanediol, pungent glycol and Sensiva SC50 are a variety of.
7. cosmetic composition according to claim 1, which is characterized in that the VB5 is coacetylase and acyl carrier egg
The important precursor of white biosynthesis is by ketopantoic acid hydroxymethyl transferases, ketopantoate reductase, L-Aspartic acid-
It is synthesized under the four kinds of enzyme concerted catalysis of α-decarboxylase and pantothenate synthetase.
8. the preparation method of the cosmetic composition described in claim 1 containing blue copper peptide, which is characterized in that including walking as follows
It is rapid:
(1) it is weighed respectively according to the weight percent of each raw material spare；
(2) Gotu Kola P.E is added in butanediol, is dissolved by heating, insulated and stirred, cooling down obtains mixed solution A；
(3) mixed solution A is uniformly mixed with blue copper peptide, purslane extract and VB5, obtains the cosmetic composition.
9. the preparation method of cosmetic composition according to any one of claims 8, which is characterized in that the purslane extract mentions
Method is taken to mention using solvent extraction method, ultrasonic wave assisted extraction method, microwave―assisted extraction, enzyme extraction method, high-pressure pulse electric
It follows the example of, homogenate/hot water extraction method.
10. any cosmetic composition containing blue copper peptide of claim 1~7 is in the skin-protection product for preparing external preparation for skin
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910689597.8A CN110237007A (en) | 2019-07-29 | 2019-07-29 | A kind of cosmetic composition and its preparation method and application containing blue copper peptide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910689597.8A CN110237007A (en) | 2019-07-29 | 2019-07-29 | A kind of cosmetic composition and its preparation method and application containing blue copper peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110237007A true CN110237007A (en) | 2019-09-17 |
Family
ID=67893705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910689597.8A Pending CN110237007A (en) | 2019-07-29 | 2019-07-29 | A kind of cosmetic composition and its preparation method and application containing blue copper peptide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110237007A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110882328A (en) * | 2019-12-20 | 2020-03-17 | 俞若熙 | Traditional Chinese medicine composition for removing acne, diminishing swelling and fading pigment as well as preparation method and application thereof |
| CN114931530A (en) * | 2022-03-22 | 2022-08-23 | 广东丸美生物技术股份有限公司 | Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof |
| CN115068361A (en) * | 2022-03-15 | 2022-09-20 | 中山中研化妆品有限公司 | Blue copper peptide double agent and use method and application thereof |
| CN115252458A (en) * | 2022-09-01 | 2022-11-01 | 上海家化联合股份有限公司 | Stable moisturizing composition containing blue copper peptide |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687109A (en) * | 2016-03-09 | 2016-06-22 | 广州千百度化妆品有限公司 | Acne-removing repair essence |
| KR20180097880A (en) * | 2017-02-24 | 2018-09-03 | 김종삼 | Chamaecyparis Obtusa water and Chlorine dioxide including various skin-improving cosmetic compositions and mask using the same |
| CN109172397A (en) * | 2018-09-20 | 2019-01-11 | 深圳市鑫煌倚天科技有限公司 | A kind of cosmetics |
-
2019
- 2019-07-29 CN CN201910689597.8A patent/CN110237007A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687109A (en) * | 2016-03-09 | 2016-06-22 | 广州千百度化妆品有限公司 | Acne-removing repair essence |
| KR20180097880A (en) * | 2017-02-24 | 2018-09-03 | 김종삼 | Chamaecyparis Obtusa water and Chlorine dioxide including various skin-improving cosmetic compositions and mask using the same |
| CN109172397A (en) * | 2018-09-20 | 2019-01-11 | 深圳市鑫煌倚天科技有限公司 | A kind of cosmetics |
Non-Patent Citations (3)
| Title |
|---|
| B: "DEAR , KLAIRS SUPPLE PREPARATION TONER", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_643E424316.HTML》 * |
| 广州品域美妆创新科技有限公司: "APOSULL爱博修蓝铜肽修护精华液", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=201907051234278EGSA&NID=201907051234278EGSA》 * |
| 广州市虎田化工有限公司: "岚泉 玉润补水面膜套组 葡聚糖玉润补水面膜", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=201710240919088OF58&NID=201710240919088OF58》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110882328A (en) * | 2019-12-20 | 2020-03-17 | 俞若熙 | Traditional Chinese medicine composition for removing acne, diminishing swelling and fading pigment as well as preparation method and application thereof |
| CN115068361A (en) * | 2022-03-15 | 2022-09-20 | 中山中研化妆品有限公司 | Blue copper peptide double agent and use method and application thereof |
| CN115068361B (en) * | 2022-03-15 | 2023-11-03 | 中山中研化妆品有限公司 | Blue copper peptide double-agent and use method and application thereof |
| CN114931530A (en) * | 2022-03-22 | 2022-08-23 | 广东丸美生物技术股份有限公司 | Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof |
| CN114931530B (en) * | 2022-03-22 | 2023-12-29 | 广东丸美生物技术股份有限公司 | Skin care composition with anti-allergy and repairing effects, application thereof, cosmetic and method thereof |
| CN115252458A (en) * | 2022-09-01 | 2022-11-01 | 上海家化联合股份有限公司 | Stable moisturizing composition containing blue copper peptide |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110237007A (en) | A kind of cosmetic composition and its preparation method and application containing blue copper peptide | |
| Roy et al. | Hair growth promoting activity of Eclipta alba in male albino rats | |
| CN103037880B (en) | The compositions of the extract containing Broussonetia papyrifera | |
| JP2011505353A (en) | Skin external preparation composition containing a compound herbal extract as an active ingredient | |
| JP2001288066A (en) | Skin barrier function ameliorator | |
| US6193975B1 (en) | Use of potentilla erecta extract in the cosmetic and pharmaceutical field | |
| KR20160120355A (en) | Skin-brightening cosmetic composition | |
| CN111481475A (en) | Edible lipstick capable of improving female hormone and preparation method thereof | |
| Shatalebi et al. | Preparation and evaluation of minoxidil foamable emu oil emulsion | |
| JP3991164B2 (en) | Cosmetic composition comprising jujube extract and walnut extract | |
| CN109512744A (en) | A kind of eyelashes growth-promoting media and preparation method thereof | |
| CN107260612B (en) | Chloasma removing composition, application, compound preparation and preparation method | |
| CN106236656B (en) | A kind of compact eye cream of rosemary | |
| KR20120139222A (en) | Composition for skin external application comprising tanshinone iia as the active ingredient | |
| CN110917105A (en) | Allergy-relieving cosmetic composition and preparation method thereof | |
| JP2009084212A (en) | Involucrin production promoter | |
| JP2001122733A (en) | Catalase production-promoting preparation and skin preparation for external use containing the same | |
| CN110302136A (en) | Whitening and skin-protecting composition | |
| CN107823079A (en) | A kind of sea cucumber EGF composition skin-care cosmetics and preparation method thereof | |
| KR101481208B1 (en) | Composition for skin external application comprising cryptotanshinone as the active ingredient | |
| KR20160036834A (en) | Skin external application composition comprising complex fermented extract of crude drug ingredients | |
| KR20100012913A (en) | Compositions for topical treatment of arthritis | |
| JPS63150210A (en) | Hair-tonic cosmetic | |
| WO2006043477A1 (en) | Nerve growth factor production inhibitor and external preparation for the skin, cosmetic, quasi drug, preventive and remedy for itching and remedy for atopic dermatitis containing the nerve growth factor production inhibitor | |
| JP3822517B2 (en) | Topical skin preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190917 |
|
| RJ01 | Rejection of invention patent application after publication |