CN110882328A - Traditional Chinese medicine composition for removing acne, diminishing swelling and fading pigment as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for removing acne, diminishing swelling and fading pigment as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for removing acne, detumescence and fading pigment, which is prepared by taking centella, radix sophorae flavescentis, purslane, dandelion, divaricate saposhnikovia root, tribulus terrestris, salvia miltiorrhiza, radix rehmanniae and poria cocos as raw materials and carrying out processes of soaking, ultrasonic extraction and the like. The invention has the beneficial effects that: experiments prove that the traditional Chinese medicine composition for removing acnes, reducing swelling and lightening pigments is safe and non-irritant to skin, can fundamentally improve skin microenvironment to achieve the effect of curing acnes, has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, dispelling wind and arresting itching, nourishing yin to lighten pigments and the like, and can relieve and eliminate scar pockmarks and the like. The acne-removing cream has the advantages of easily obtained raw materials, simple and convenient preparation method, greenness, safety, good acne-removing effect, easy acceptance by consumers and good application prospect and market prospect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for removing acnes, relieving swelling and fading pigments, and a preparation method and application thereof.
Background
The acne is a chronic inflammatory dermatosis caused by the obstruction and inflammation of hair follicles and sebaceous glands, is commonly seen in young men and women in the pubertal stage, mainly occurs on the face, neck, chest, back, shoulders and upper arms to form papules, is called as acne in traditional Chinese medicine, and is named as acne in western medicine. In adolescence, androgen is increased, sebaceous gland secretion is increased, meanwhile, hair follicles and sebaceous glands are over-keratinized, flat dead cells dropped from cuticle layers fall down the infundibulum of the hair follicles to be combined with sebum, and a mixture is generated. If the mixture is not free to drain out of the skin surface, it will pool in the hair follicle and form a lipid plug. Mature comedones are formed when these abnormal keratinocytes aggregate and the lower funnel swells. Sebum is broken down by bacteria present in the hair follicle, producing fatty acids which stimulate the follicle to cause inflammation, causing the follicle wall to rupture and the follicle contents to enter the dermis, thereby causing an inflammatory response of varying degrees around the follicle.
The mechanism of whelk occurrence is related to the following three major factors:
(1) the reasons for the reaction to androgenic steroids (such as testosterone, dehydroepiandrosterone, hydroxyprogesterone) are not clearly aggravated, resulting in increased sebum production;
(2) propionibacterium acnes proliferates. This bacterium is composed of a normal flora of hair follicles, which uses sebum as its action mechanism and converts it partially into free fatty acids. Propionibacterium acnes can also activate the complement pathway, produce at least two chemokines, and promote inflammation;
(3) the capsular epithelial cells increase in number and are adhesive, forming follicular retention hyperkeratosis. The reason for the latter occurrence is not yet clear. Acne propionic acid bacteria produce free fatty acids and may be a major factor in the formation of acne.
The existing acne removing products on the market have the following problems: 1. easily cause skin allergy and has great skin irritation; 2. adding chemical bacteriostatic agent to destroy normal flora of skin; 3. adding some forbidden substances such as hormones like chloramphenicol; 4. adding heavy metal substances.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine composition for removing acnes, swelling and fading pigments and a preparation method and application thereof.
The invention aims to provide a traditional Chinese medicine composition for removing acnes, reducing swelling and lightening pigments.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for removing acnes, reducing swelling and lightening pigments.
The invention further aims to provide the application of the composition with the effects of removing acnes, reducing swelling and lightening pigments.
According to the specific embodiment of the invention, the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment is prepared from the following raw materials:
centella, radix sophorae flavescentis, purslane, dandelion, radix sileris, tribulus terrestris, salvia miltiorrhiza, radix rehmanniae and poria cocos.
The traditional Chinese medicine composition for removing the acne, diminishing the swelling and lightening the pigment according to the specific embodiment of the invention is prepared from the following raw materials in parts by weight:
15-25 parts of centella, 15-25 parts of radix sophorae flavescentis, 25-35 parts of purslane, 5-15 parts of dandelion, 5-15 parts of divaricate saposhnikovia root, 5-15 parts of tribulus terrestris, 5-15 parts of salvia miltiorrhiza, 5-15 parts of radix rehmanniae and 5-15 parts of poria cocos.
The traditional Chinese medicine composition for removing the acne, diminishing the swelling and lightening the pigment according to the specific embodiment of the invention is prepared from the following raw materials in parts by weight:
20 parts of centella, 20 parts of radix sophorae flavescentis, 30 parts of purslane, 10 parts of dandelion, 10 parts of divaricate saposhnikovia root, 10 parts of tribulus terrestris, 10 parts of salvia miltiorrhiza, 10 parts of radix rehmanniae and 10 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to the specific embodiment of the invention comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing and soaking all the raw materials in purified water for more than 60 minutes to form a traditional Chinese medicine soaking solution;
(2) and (2) carrying out ultrasonic extraction on the Chinese medicinal soaking solution obtained in the step (1) for more than 60 minutes, then filtering, and removing Chinese medicinal residues to obtain a filtrate, namely the Chinese medicinal composition for removing acne, diminishing swelling and lightening pigment.
The preparation method of the traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment according to the specific embodiment of the invention comprises the step (1), wherein the soaking temperature is 50-60 ℃.
According to the specific embodiment of the invention, the preparation method of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment comprises the step (1), wherein the adding amount of the purified water is 3-4cm higher than that of the raw materials.
The preparation method of the traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment according to the specific embodiment of the invention comprises the step (2) of extracting with ultrasonic waves at the temperature of 40-65 ℃.
The preparation method of the traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment according to the specific embodiment of the invention is characterized in that the temperature of ultrasonic extraction is 60 ℃. The ultrasonic extraction time is 20-40 minutes.
The ultrasonic extraction method is an extraction method which utilizes the cavitation, mechanical effect, thermal effect and the like of ultrasonic waves to accelerate the release, diffusion and dissolution of intracellular effective substances and obviously improve the extraction efficiency. The main theoretical bases of ultrasonic extraction are cavitation effect, thermal effect and mechanical action of ultrasound. When ultrasonic waves of large energy are applied to the medium, the medium is torn into many small cavities, which are instantaneously closed and generate an instantaneous pressure of up to several thousand atmospheric pressures, i.e., a cavitation phenomenon. The bursting of the micro-bubbles in the ultrasonic cavitation can generate great pressure, so that the rupture of plant cell walls and the whole organism is completed instantly, the breaking time is shortened, and meanwhile, the vibration effect generated by the ultrasonic waves enhances the release, diffusion and dissolution of intracellular substances, thereby obviously improving the extraction efficiency.
The ultrasonic extraction has the following characteristics:
1. the ultrasonic extraction efficiency is high
The unique physical properties of the ultrasonic wave can promote the wall breaking or deformation of plant cell tissues, so that the effective components of the traditional Chinese medicine can be extracted more fully, and the extraction rate is improved by 50-500 percent compared with the traditional process;
2. short extraction time
The ultrasonic-enhanced traditional Chinese medicine extraction can obtain the optimal extraction rate within 24-40 minutes, the extraction time is greatly shortened by more than 2/3 compared with the traditional method, and the treatment capacity of raw materials of medicinal materials is large;
3. the extraction temperature is low
The optimum temperature for ultrasonic extraction of the traditional Chinese medicinal materials is 40-60 ℃, has a protective effect on the effective components in the medicinal materials which are unstable and easy to hydrolyze or oxidize when encountering heat, and simultaneously greatly saves energy and consumes energy.
The preparation method of the traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment according to the specific embodiment of the invention comprises the step (2), wherein the filtering is performed by adopting a 100-200-mesh sieve.
According to the application of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment, the traditional Chinese medicine composition is prepared into an external skin care product, and the external skin care product comprises external handmade soap, facial cleanser, facial cream, aqua or spray.
The traditional Chinese medicine composition for removing acne, detumescence and lightening pigment can be prepared into powder or essence for external application on skin, and can also be prepared into external skin care products, external handmade soap, facial cleanser, facial cream, aqua or spray and the like. But not limited to the above form, various skin care products can be prepared according to the methods known in the field of skin care product industry.
The traditional Chinese medicine composition for removing acnes, reducing swelling and lightening pigments is prepared by monarch, minister, assistant and guide medicines, and specifically comprises the following components:
monarch: centella, radix sophorae flavescentis, purslane and dandelion have the effects of clearing away heat and toxic materials, diminishing inflammation and diminishing swelling, directly relieving inflammatory reaction on the surface of skin, killing acne bacillus and the like;
minister: divaricate saposhnikovia root and tribulus terrestris, dispelling wind, relieving itching, relieving discomfort such as itching of skin and the like;
and (2) adjuvant: the salvia miltiorrhiza and the radix rehmanniae nourish yin and activate blood, supplement water and body fluid to the skin from the soil and promote the blood circulation of the epidermis;
the following steps are performed: poria cocos, and Poria cocos, and Poria.
The traditional Chinese medicine composition has comprehensive effects in clearing away heat and toxic materials, killing parasites to relieve itching, promoting blood circulation for removing blood stasis, nourishing yin and skin, and removing pigment, thereby achieving the effects of treating both manifestation and root cause of disease, removing acne and swelling, and removing pigment.
Compared with the prior art, the invention has the following beneficial effects:
(1) the traditional Chinese medicine composition for removing acnes, reducing swelling and lightening pigments extracts active ingredients of a plurality of herbaceous plants by using an ultrasonic extraction technology, and is added into carriers contacting skin such as handmade soap, facial masks, skin care products and the like, so that oily skin can be effectively relieved, acnes can be removed, swelling can be reduced, and the pigments can be lightened.
(2) The invention utilizes advanced technology and combines the theory of traditional Chinese medicine, centella, radix sophorae flavescentis, purslane, dandelion, divaricate saposhnikovia root, tribulus terrestris, salvia miltiorrhiza, radix rehmanniae and poria cocos are effectively combined together to form a compound preparation, and the compound preparation is used as an active component and added into acne removing, face cleaning and skin care to enable the compound preparation to have the effects of resisting bacteria, promoting penetration, clearing heat and removing toxicity, and activating blood and reducing swelling, so that different types of acnes can be effectively prevented and treated, and new vitality and vitality are endowed to the skin.
(3) The traditional Chinese medicine composition for removing acne, detumescence and fading pigment disclosed by the invention achieves the effects of clearing heat and removing toxicity, activating blood circulation to dissipate blood stasis, dispelling wind and arresting itching, nourishing yin and fading pigment through monarch, minister, assistant and guide compatibility; wherein, 20g of centella, 20g of radix sophorae flavescentis, 30g of purslane and 10g of dandelion are monarch drugs; 10g of divaricate saposhnikovia root and 10g of tribulus terrestris are taken as ministerial drugs; 10g of salvia miltiorrhiza is used as an adjuvant drug; 10g of dried rehmannia root and 10g of tuckahoe are taken as guiding drugs.
(4) The raw materials of the acne-removing cream provided by the invention are all natural plant components, and experiments prove that the acne-removing cream is safe and non-irritant to skin, can fundamentally improve skin microenvironment to achieve the effect of curing acne, has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, dispelling wind and arresting itching, nourishing yin to remove pigments and the like, and can relieve and eliminate scar pockmarks and the like. The acne-removing cream has the advantages of easily obtained raw materials, simple and convenient preparation method, greenness, safety, good acne-removing effect, easy acceptance by consumers and good application prospect and market prospect.
In the invention, the components and the proportion of the raw materials are very critical, after the components and the proportion are known, a person skilled in the art can extract the effective components by adopting various conventional methods for extracting the effective components of the traditional Chinese medicine, such as a decoction method, a water extraction and alcohol precipitation method, a salting-out method, an organic solvent extraction method and the like, and because the extraction methods can obtain the main effective components in the formula of the traditional Chinese medicine, the traditional Chinese medicine has certain curative effect on relieving muscle tension and pain.
Wherein, the organic solvent extraction method comprises the following steps: the specific active ingredients in the medicinal materials are extracted in a targeted manner after common solvents such as ethyl acetate, acetic acid, triethylamine and the like are mixed with ethanol or water according to a certain proportion. The specific medicinal components with high purity can be extracted by an organic solvent extraction method.
The method for concentrating the finished product to prepare essence or powder comprises but is not limited to: atmospheric evaporation, reduced pressure evaporation, thin film evaporation, multiple effect evaporation, and purification methods include but are not limited to: salting-out purification, macroporous resin adsorption purification, ethanol precipitation purification, ion exchange resin purification, flocculation precipitation purification, membrane separation purification, polyamide adsorption purification, silica gel adsorption chromatography purification, etc.
Methods of drying include, but are not limited to: drying, drum drying, belt drying, moisture absorption drying, boiling drying, spray drying, reduced pressure drying, freeze drying, infrared drying, microwave drying, etc.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
The embodiment provides a traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment, which is prepared from the following raw materials:
15g of centella, 25g of radix sophorae flavescentis, 25g of purslane, 15g of dandelion, 5g of divaricate saposhnikovia root, 15g of tribulus terrestris, 5g of salvia miltiorrhiza, 15g of radix rehmanniae and 5g of poria cocos.
The preparation method comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing and soaking all the raw materials in purified water for 60 minutes to form a traditional Chinese medicine soaking solution;
(2) and (2) carrying out ultrasonic extraction on the Chinese medicinal soaking solution obtained in the step (1) for 60 minutes, then filtering, removing the Chinese medicinal residues, obtaining a filtrate, and carrying out freeze drying to obtain powder, namely the Chinese medicinal composition for removing acnes, diminishing swelling and lightening pigments.
Example 2
The embodiment provides a traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment, which is prepared from the following raw materials:
25g of centella, 15g of radix sophorae flavescentis, 35g of purslane, 5g of dandelion, 15g of divaricate saposhnikovia root, 5g of tribulus terrestris, 15g of salvia miltiorrhiza, 5g of radix rehmanniae and 15g of poria cocos.
The preparation method comprises the following steps:
(1) weighing raw materials according to a ratio, mixing all the raw materials, and soaking in purified water at 60 deg.C for more than 60 minutes, wherein the addition amount of purified water is 4cm above the raw materials to form a Chinese medicinal soaking solution;
(2) and (2) carrying out ultrasonic extraction on the Chinese medicinal soaking solution obtained in the step (1) at 40 ℃ for more than 60 minutes, then filtering by adopting a 100-mesh sieve, and removing Chinese medicinal residues to obtain a filtrate, namely the Chinese medicinal composition for removing acnes, diminishing swelling and lightening pigments.
(3) The traditional Chinese medicine composition is prepared into an external skin care product, and the external skin care product is concentrated and then is respectively added into the traditional handmade soap, facial cleanser and facial cream.
Example 3
The embodiment provides a traditional Chinese medicine composition for removing acne, diminishing swelling and lightening pigment, which is prepared from the following raw materials:
20g of centella, 20g of radix sophorae flavescentis, 30g of purslane, 10g of dandelion, 10g of divaricate saposhnikovia root, 10g of tribulus terrestris, 10g of salvia miltiorrhiza, 10g of radix rehmanniae and 10g of poria cocos.
The preparation method comprises the following steps:
(1) weighing raw materials according to a ratio, mixing all the raw materials, and soaking in purified water at 55 deg.C for more than 60 minutes, wherein the addition amount of purified water is 3cm higher than the raw materials to form a Chinese medicinal soaking solution;
(2) and (2) carrying out ultrasonic extraction on the traditional Chinese medicine soaking solution obtained in the step (1) at the temperature of 60 ℃ for more than 60 minutes, then filtering by adopting a 200-mesh sieve, removing the traditional Chinese medicine residues to obtain a filtrate, and concentrating the filtrate into essence to obtain the traditional Chinese medicine composition for removing the acne, diminishing swelling and lightening the pigment.
Comparative example 1
The only difference between this comparative example and example 3 is that purslane is not added to the raw materials, nor is purslane added during the preparation process.
Comparative example 2
The only difference between this comparative example and example 3 is that no tribulus terrestris is added to the raw materials and no tribulus terrestris is added during the preparation process.
Acne removing, oil removing and spot lightening effects
In order to evaluate the effects of the Chinese medicinal composition on removing acne, removing oil and lightening spots, test experiments were carried out on 300 patients.
Test objects: 150 ordinary face acne vulgaris volunteers with mild and moderate facial acne and 150 patients with acne marks on face. The composition is divided into three groups, each group comprises 100 persons, and each group comprises 50 light and medium facial ordinary acne volunteers and 50 patients with acne marks on their faces.
The test method comprises the following steps: the first group is to uniformly apply the traditional Chinese medicine composition obtained in the embodiment 3 of the invention on the face, 1.5 g of the traditional Chinese medicine composition is applied each time, and the change before and after the traditional Chinese medicine composition is used for one month is observed; the second group is coated with the traditional Chinese medicine composition obtained in the comparative example 1; the third group is coated with the traditional Chinese medicine composition obtained in the comparative example 2.
Comprehensive evaluation criteria of use effect:
the acne cream has excellent effects of no allergy, fine pores, eliminating red swelling, fading acne marks, tightening skin, removing acne and swelling, no greasiness and very obvious effect;
the effect is better: the acne cream has the advantages of no allergy, fine pores, red and swollen elimination, acne mark fading, skin tightness, acne removal and swelling reduction, no greasiness and obvious effect;
the effect is general: the acne cream has the advantages of no allergy, fine pores, red and swollen elimination, acne mark fading, skin tightness, acne removal and swelling reduction, no greasiness and general effect;
the effect is poor, and the effect is not reflected basically.
Test results
The results, which will be compared before and after use, are shown in table 2 below:
TABLE 2 comparison before and after use
| Comprehensive evaluation | Has excellent effect | Has better effect | General effects | The effect is poor |
| Example 3 | 87 | 7 | 4 | 2 |
| Comparative example 1 | 43 | 19 | 27 | 11 |
| Comparative example 2 | 29 | 31 | 21 | 19 |
As can be seen from the table 2, the Chinese medicinal composition for removing the acne, diminishing the swelling and lightening the pigment can obviously and effectively relieve oily skin and the acne, diminishing the swelling and lightening the pigment after one month. The purslane and the tribulus terrestris in the raw materials have very key functions.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The traditional Chinese medicine composition for removing acnes, swelling and fading pigments is characterized by being prepared from the following raw materials:
centella, radix sophorae flavescentis, purslane, dandelion, radix sileris, tribulus terrestris, salvia miltiorrhiza, radix rehmanniae and poria cocos.
2. The traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to claim 1, which is prepared from the following raw materials in parts by weight:
15-25 parts of centella, 15-25 parts of radix sophorae flavescentis, 25-35 parts of purslane, 5-15 parts of dandelion, 5-15 parts of divaricate saposhnikovia root, 5-15 parts of tribulus terrestris, 5-15 parts of salvia miltiorrhiza, 5-15 parts of radix rehmanniae and 5-15 parts of poria cocos.
3. The traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to claim 1, which is prepared from the following raw materials in parts by weight:
20 parts of centella, 20 parts of radix sophorae flavescentis, 30 parts of purslane, 10 parts of dandelion, 10 parts of divaricate saposhnikovia root, 10 parts of tribulus terrestris, 10 parts of salvia miltiorrhiza, 10 parts of radix rehmanniae and 10 parts of poria cocos.
4. A method for preparing the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to any one of claims 1 to 3, which comprises the following steps:
(1) weighing the raw materials according to the proportion, mixing and soaking all the raw materials in purified water for more than 60 minutes to form a traditional Chinese medicine soaking solution;
(2) and (2) carrying out ultrasonic extraction on the Chinese medicinal soaking solution obtained in the step (1) for more than 60 minutes, then filtering, and removing Chinese medicinal residues to obtain a filtrate, namely the Chinese medicinal composition for removing acne, diminishing swelling and lightening pigment.
5. The preparation method of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to claim 4, wherein in the step (1), the soaking temperature is 50-60 ℃.
6. The preparation method of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to claim 4, wherein in the step (1), the addition amount of the purified water is 3-4cm higher than that of the raw material.
7. The preparation method of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to claim 4, wherein in the step (2), the temperature of the ultrasonic extraction is 40-65 ℃.
8. The preparation method of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to claim 7, wherein the temperature of the ultrasonic extraction is 60 ℃.
9. The method for preparing a Chinese medicinal composition for removing acne, detumescence and lightening pigment according to claim 4, wherein in the step (2), the filtering is performed by using a 100-200 mesh sieve.
10. The use of the traditional Chinese medicine composition for removing acne, detumescence and lightening pigment according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition is prepared into an external skin care product, and the external skin care product comprises external handmade soap, facial cleanser, cream, aqua or spray.
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