CN112006961A - Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask - Google Patents
Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask Download PDFInfo
- Publication number
- CN112006961A CN112006961A CN202010978121.9A CN202010978121A CN112006961A CN 112006961 A CN112006961 A CN 112006961A CN 202010978121 A CN202010978121 A CN 202010978121A CN 112006961 A CN112006961 A CN 112006961A
- Authority
- CN
- China
- Prior art keywords
- acne
- traditional chinese
- chinese medicine
- medicine mask
- removing traditional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 64
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 53
- 206010000496 acne Diseases 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 241001096409 Peristrophe japonica Species 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 11
- 239000003960 organic solvent Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 239000000706 filtrate Substances 0.000 claims abstract description 6
- 238000010992 reflux Methods 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 238000002390 rotary evaporation Methods 0.000 claims abstract description 5
- 238000000605 extraction Methods 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- 241001290726 Peristrophe Species 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 3
- 239000003495 polar organic solvent Substances 0.000 claims description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 230000000172 allergic effect Effects 0.000 abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 abstract description 4
- 229940088710 antibiotic agent Drugs 0.000 abstract description 4
- 208000010668 atopic eczema Diseases 0.000 abstract description 4
- 230000007547 defect Effects 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 241000588747 Klebsiella pneumoniae Species 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229940055019 propionibacterium acne Drugs 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000186429 Propionibacterium Species 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 208000020154 Acnes Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010054107 Nodule Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of acne-removing traditional Chinese medicine mask essence, which comprises the following steps: the preparation method comprises the steps of taking peristrophe japonica as a raw material, extracting for 2 times by using an organic solvent and a heating reflux extraction method for 1 hour each time, mixing filtrates, carrying out rotary evaporation to obtain an extract, and preparing the acne-removing traditional Chinese medicine mask essence containing the peristrophe japonica by using distilled water added with dimethyl sulfoxide. The invention also provides the acne-removing traditional Chinese medicine mask. The invention has the following advantages: the defects that the existing antibiotics for treating acne easily generate drug resistance, are easy to relapse, are high in price and harsh in use condition, and cannot be used by patients with allergic constitution by themselves are overcome; the traditional Chinese medicine acne-removing mask well fills the market blank of the traditional Chinese medicine acne-removing mask for severe whelk (acne), and has higher social and economic benefits.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of beauty and skin care products, and particularly relates to a preparation method of acne-removing traditional Chinese medicine mask essence and an acne-removing traditional Chinese medicine mask.
[ background of the invention ]
Acne is mainly caused by endocrine dyscrasia, propionibacterium acnes and various bacterial infections, the propionibacterium acnes live on fatty acids in human pores, when the pores are blocked, the propionibacterium acnes can crazy grow, saturated fatty acids are decomposed, a large amount of free fatty acids are produced, and the fatty acids permeate into skin through the pores, so that skin stress reaction can be caused, and acnes, red swelling and the like are produced. Some pathogenic bacteria such as staphylococcus, hemolytic streptococcus, pseudomonas aeruginosa and the like are adhered to the skin through the discharged pus, so that skin tissues are damaged, and acne is formed. More severe acne caused by bacterial infection is clinically manifested as papules, pustules, nodules, cysts, etc. The traditional Chinese medicine facial mask on the current market is mainly used for treating slight non-inflammatory hair follicle blockage type acne, and relatively serious acne caused by bacterial infection is generally treated by antibiotics.
However, the antibiotic used for treating acne pathogenic bacteria is easy to generate drug resistance, which can cause the acne to occur repeatedly; allergic reaction is easily caused by patients with allergic constitution, and severe shock is caused. Resulting in expensive and harsh conditions for use, which is inconvenient for the patient to use by himself.
[ summary of the invention ]
The invention aims to provide a preparation method of acne-removing traditional Chinese medicine mask essence and an acne-removing traditional Chinese medicine mask, and can solve the technical problems related to the background technology.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a preparation method of acne-removing traditional Chinese medicine mask essence comprises the following steps: the preparation method comprises the steps of taking peristrophe japonica as a raw material, extracting for 2 times by using an organic solvent and a heating reflux extraction method for 1 hour each time, mixing filtrates, carrying out rotary evaporation to obtain an extract, and preparing the acne-removing traditional Chinese medicine mask essence containing the peristrophe japonica by using distilled water added with dimethyl sulfoxide.
Preferably: also comprises a step of crushing and impurity removal, namely removing impurities from the peristrophe raw material and then crushing.
Preferably: the organic solvent is polar organic solvent such as methanol.
Preferably: the solubility of peristrophe japonica in the acne-removing traditional Chinese medicine mask essence is more than or equal to 0.0039 g/mL.
The invention also provides an acne-removing traditional Chinese medicine mask which is prepared from the acne-removing traditional Chinese medicine mask essence.
Compared with the related technology, the preparation method of the acne-removing traditional Chinese medicine mask essence provided by the invention has the following advantages: the defects that the existing antibiotics for treating acne easily generate drug resistance, are easy to relapse, are high in price and harsh in use condition, and cannot be used by patients with allergic constitution by themselves are overcome; the traditional Chinese medicine acne-removing mask well fills the market blank of the traditional Chinese medicine acne-removing mask for severe whelk (acne), and has higher social and economic benefits.
[ description of the drawings ]
In order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced, wherein:
fig. 1 is a comparison graph of the effects of the acne-removing traditional Chinese medicine mask essence before and after the test.
[ detailed description ] embodiments
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a preparation method of acne-removing traditional Chinese medicine mask essence, which comprises the following steps: the acne-removing traditional Chinese medicine facial mask essence containing the peristrophe is prepared by taking the peristrophe as a raw material, extracting for 2 times by using an organic solvent and a heating reflux extraction method for 1 hour each time, combining filtrates, carrying out rotary evaporation to obtain an extract, and adding distilled water of dimethyl sulfoxide into the extract to prepare the acne-removing traditional Chinese medicine facial mask essence containing the peristrophe with the solubility of not less than 0.0039 g/mL.
It needs to be further explained that: also comprises a step of crushing and impurity removal, namely removing impurities from the peristrophe raw material and then crushing. The organic solvent is polar organic solvent such as methanol.
The invention also provides an acne-removing traditional Chinese medicine mask which is prepared from the acne-removing traditional Chinese medicine mask essence.
The effect of the acne-removing traditional Chinese medicine mask essence containing peristrophe japonica is verified by experiments, and the specific experimental steps are as follows:
the method comprises the following steps: preparing a liquid medicine; removing impurities from the collected peristrophe japonica, crushing, weighing 50g, heating and refluxing for 2 times with 100ml of dichloromethane for 1 hour each time, mixing filtrates, performing rotary evaporation to obtain an extract, washing the flask with 100ml of distilled water added with dimethyl sulfoxide, dissolving out effective components, performing suction filtration on the solution, and fixing the volume to 0.5g/ml to obtain a liquid medicine 1; sealing and storing in refrigerator. Extracting the residue with 100ml ethyl acetate under reflux for 2 times, each for 1 hr, mixing filtrates, rotary steaming to obtain extract, washing flask with 100ml distilled water containing dimethyl sulfoxide, dissolving out effective components, vacuum filtering, and metering to 0.5g/ml to obtain medicinal liquid 2; sealing, storing in refrigerator, and sequentially adding n-butanol and methanol to obtain medicinal liquid 3 and 4;
step two: preparing drug-containing test tubes with different concentrations; adopting a test tube dilution method, taking 10 clean test tubes, numbering, taking 2 times of concentrated broth 2ml from the test tube numbered a-j, sucking 2ml of peristrophe methylene dichloride extract by using a pipette gun, namely adding the medicine liquid 1(0.5g/ml) into the first test tube, fully mixing uniformly, sucking 2ml of solution into the next test tube, fully mixing uniformly and sequentially diluting to the 7 th test tube in a double way to prepare medicine liquid test tubes with different concentrations, wherein the medicine concentration of each test tube is respectively 0.25g/ml, 0.152g/ml, 0.0625g/ml, 0.0312g/ml, 0.0156g/ml, 0.0078g/ml and 0.0039g/ml, the numbering is 1a, 1b, 1c, 1d, 1e, 1f and 1g, 1 is sterile and has no medicine, 1 is positive control, after 10 test tubes are added with cotton plugs at the temperature of 115.95 kp for 20min, sequentially operating the liquid medicine 2, the liquid medicine 3, the liquid medicine 4 and the liquid medicine 5 according to the method;
step three: preparing a bacterial liquid; staphylococcus aureus [ cmcc (b)26003 ]; large intestine Escherichia [ CMCC (B)44103 ]; pseudomonas aeruginosa; propionibacterium; activating Klebsiella pneumoniae, and preparing a bacterial solution with the concentration of 5 multiplied by 105cfu/ml by using sterile normal saline for standby;
step four: inoculating; by micro-mirrorsAdding 100 μ l of bacteria solution with different concentrations into 7 test tubes containing medicine, sequentially increasing from low concentration to high concentration, and controlling the final inoculation bacterial amount to be about 5 × 105cfu/ml, the other 3 test tubes are respectively used for drug-containing and sterile, bacteria-containing and sterile and western medicine positive control, and the transferred bacterial liquid is inoculated within 15 min;
step five: culturing and observing; and (3) sequentially taking 2ml of the inoculated liquid medicine by using a pipette, adding into a clean culture dish, adding nutrient broth with a proper volume, slowly shaking up, incubating at 35 ℃ overnight, counting, and confirming that the liquid medicine with the component has an inhibiting effect on the bacteria if the colony number on the culture dish is less than that of bacteria and no medicine.
The experimental results are shown in Table 1.
TABLE 1 inhibition and killing effect of five extracts of peristrophe japonica on 5 strains of bacteria
Note: "+" indicates the presence of bacteria; the mixed liquid medicine is a mixed extract of four organic solvent extracts of dichloromethane, ethyl acetate, n-butanol and methanol. The staphylococcus aureus is gram-positive bacteria; escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus proteus are gram-negative bacteria; the escherichia coli shows negative when the medicine is available and sterile, and the colony number of the bacteria is 100; the pseudosingle aeruginosa is negative in terms of drug-containing sterility, and the number of the bacterial colonies with bacteria and sterility is 98; the propionibacterium shows negative bacteria in the presence of drugs and the number of bacteria colonies with bacteria and no drugs is 100; the staphylococcus aureus has a negative sterile display after being filled with a medicament, and the bacterial colony number of the staphylococcus aureus is 95; the Klebsiella pneumoniae shows negative bacteria-free property when being used with medicine, and the bacterial colony number of the Klebsiella pneumoniae is 95.
In conclusion, small-scale tests (25 cases) show that the acne-removing traditional Chinese medicine facial mask essence containing peristrophe japonica can effectively remove acne. The revisit survey of 1 year proves that the product solves the defects that the existing antibiotics for treating acne easily generate drug resistance, are easy to relapse, have high price and harsh use conditions, and can not be used by patients with allergic constitution; the traditional Chinese medicine acne-removing mask well fills the market blank of the traditional Chinese medicine acne-removing mask for severe whelk (acne), and has higher social and economic benefits.
While embodiments of the invention have been disclosed above, it is not limited to the applications set forth in the specification and the embodiments, which are fully applicable to various fields of endeavor for which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.
Claims (5)
1. A preparation method of acne-removing traditional Chinese medicine mask essence is characterized by comprising the following steps: the method comprises the following steps: the preparation method comprises the steps of taking peristrophe japonica as a raw material, extracting for 2 times by using an organic solvent and a heating reflux extraction method for 1 hour each time, mixing filtrates, carrying out rotary evaporation to obtain an extract, and preparing the acne-removing traditional Chinese medicine mask essence containing the peristrophe japonica by using distilled water added with dimethyl sulfoxide.
2. The preparation method of the acne-removing traditional Chinese medicine mask essence according to claim 1, which is characterized by comprising the following steps: also comprises a step of crushing and impurity removal, namely removing impurities from the peristrophe raw material and then crushing.
3. The preparation method of the acne-removing traditional Chinese medicine mask essence according to claim 1, which is characterized by comprising the following steps: the organic solvent is polar organic solvent such as methanol.
4. The preparation method of the acne-removing traditional Chinese medicine mask essence according to claim 1, which is characterized by comprising the following steps: the solubility of peristrophe japonica in the acne-removing traditional Chinese medicine mask essence is more than or equal to 0.0039 g/mL.
5. The acne-removing traditional Chinese medicine mask is characterized in that: is prepared from the acne-removing traditional Chinese medicine mask essence of any one of claims 1 to 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010978121.9A CN112006961A (en) | 2020-09-17 | 2020-09-17 | Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010978121.9A CN112006961A (en) | 2020-09-17 | 2020-09-17 | Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112006961A true CN112006961A (en) | 2020-12-01 |
Family
ID=73521636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010978121.9A Pending CN112006961A (en) | 2020-09-17 | 2020-09-17 | Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112006961A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1778378A (en) * | 2004-11-28 | 2006-05-31 | 黄阳生 | Production of externally-applied for treating acne |
| JP2012149020A (en) * | 2011-01-21 | 2012-08-09 | Kao Corp | Skin whitening agent |
| CN103313696A (en) * | 2011-01-21 | 2013-09-18 | 花王株式会社 | Skin whitening agent |
| CN104623218A (en) * | 2015-02-13 | 2015-05-20 | 尤娜 | Traditional Chinese medicine facial mask for treating acne and preparation method thereof |
| CN104707057A (en) * | 2015-03-30 | 2015-06-17 | 广州市络捷生物科技有限公司 | Composition with acne removing effect as well as preparation method and application thereof |
| CN107519081A (en) * | 2017-08-25 | 2017-12-29 | 杭州惠博士健康产业有限公司 | A kind of composition and preparation method that effect is repaired with anti-acne |
| CN110882328A (en) * | 2019-12-20 | 2020-03-17 | 俞若熙 | Traditional Chinese medicine composition for removing acne, diminishing swelling and fading pigment as well as preparation method and application thereof |
-
2020
- 2020-09-17 CN CN202010978121.9A patent/CN112006961A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1778378A (en) * | 2004-11-28 | 2006-05-31 | 黄阳生 | Production of externally-applied for treating acne |
| JP2012149020A (en) * | 2011-01-21 | 2012-08-09 | Kao Corp | Skin whitening agent |
| CN103313696A (en) * | 2011-01-21 | 2013-09-18 | 花王株式会社 | Skin whitening agent |
| CN104623218A (en) * | 2015-02-13 | 2015-05-20 | 尤娜 | Traditional Chinese medicine facial mask for treating acne and preparation method thereof |
| CN104707057A (en) * | 2015-03-30 | 2015-06-17 | 广州市络捷生物科技有限公司 | Composition with acne removing effect as well as preparation method and application thereof |
| CN107519081A (en) * | 2017-08-25 | 2017-12-29 | 杭州惠博士健康产业有限公司 | A kind of composition and preparation method that effect is repaired with anti-acne |
| CN110882328A (en) * | 2019-12-20 | 2020-03-17 | 俞若熙 | Traditional Chinese medicine composition for removing acne, diminishing swelling and fading pigment as well as preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 于秀路 等: "《新编外用药物手册》", 30 September 1996, 山东科学技术出版社 * |
| 国家药品监督管理局: "《化妆品安全技术规范》", 23 December 2015 * |
| 张丽娟 等: ""九头狮子草抗菌有效组分分析"", 《食品与机械》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Florey | The use of micro-organisms for therapeutic purposes | |
| CN104940239B (en) | Cockroach extract and preparation method and application thereof | |
| CN108685996A (en) | It is a kind of to be used to prevent external natural pharmaceutical composition of acne and preparation method thereof | |
| TWI825362B (en) | Use of lactobacillus fermentation product in preparation of external composition for enhancing skin wound healing | |
| CN109593114B (en) | Limax antibacterial peptide, extraction method and application thereof | |
| CN107794232B (en) | Streptococcus antagonizing growth of propionibacterium acnes and gram-positive bacteria and metabolites thereof | |
| CN112353833A (en) | New use of Pterocarpus heterophyllus extract | |
| CN112006961A (en) | Preparation method of acne-removing traditional Chinese medicine mask essence and acne-removing traditional Chinese medicine mask | |
| CN103054969A (en) | Compound skin disinfectant and preparation method thereof | |
| CN111905058A (en) | Pharmaceutical composition for skin mucosa nursing and wound repair and preparation method thereof | |
| CN112336715B (en) | Application of inula britannica extract in preparation of medicine for treating swine pleuropneumonia actinobacillus | |
| Gharieb et al. | Efficacy of pyocyanin produced by Pseudomonas aeruginosa as a topical treatment of infected skin of rabbits | |
| CN102300976B (en) | Soap composition for treating acne containing absolute ginseng essential oil | |
| CN104857116B (en) | Application of the Chinese medicine garden burnet in preparing antifungal medicine synergist | |
| Xu et al. | Application of Atractylodes Macrocephala Koidz Extract in Methicillin-Resistant Staphylococcus Aureus | |
| CN104083406A (en) | Compound disinfectant and preparation method thereof | |
| CN108653342A (en) | A kind of microbial antibacterial extract and its preparation method and application | |
| CN1462584A (en) | Externally-used disinfector | |
| US9980998B2 (en) | Medicinal composition having antibiotic, anti-inflammatory, and wound healing activity | |
| CN113546100B (en) | Application of pachyrhizus extract in preparation of antibacterial product | |
| CN104288043A (en) | Method for preparing natural plant antibacterial hand-washing solution | |
| JAIN¹ et al. | Antibacterial activity of seeds, stems and roots of Leea aequata | |
| CN102895282B (en) | Isatis root extracting solution and nano-silver bacteriostatic composition | |
| CN108186617A (en) | The new application of geraniol and its derivative in MRSA infectious disease medicaments are prepared | |
| CN102423357B (en) | Compound propolis composition spray for treating livestock foot-and-mouth disease and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201201 |