CN1462584A - Externally-used disinfector - Google Patents
Externally-used disinfector Download PDFInfo
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- CN1462584A CN1462584A CN 03133391 CN03133391A CN1462584A CN 1462584 A CN1462584 A CN 1462584A CN 03133391 CN03133391 CN 03133391 CN 03133391 A CN03133391 A CN 03133391A CN 1462584 A CN1462584 A CN 1462584A
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- disinfectant
- aloe
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Abstract
An externally-applied disinfectant for the surface of human body is prepared from cinrofloxacin lactate and the extracts of 4 Chinese-medicinal materials including portulace, cnidium fruit, flavescent sophora root and aloe. Its advantages are broad spectrum, high disinfecting power, quickly taking its high effect, no irritation, corrosion and poison.
Description
(1) technical field
The present invention relates to a kind of disinfectant, particularly relate to a kind of disinfectant for external use of Chinese and Western medicine combination with broad-spectrum bactericidal action.
(2) background technology
Good health and a long life are human eternal pursuing one's goal, and are along with the raising day by day of people's living standard, more urgent to healthy beautiful pursuit.Disease of skin, women's vaginal disease has become common disease, frequently-occurring disease, as skin infection, sore rash, erysipelas, cellulitis, tinea pedis infection, the infection of ear schneiderian membrane, oral mucosa infection, perianal abscess, diseases such as vaginitis, cervical erosion, pudendal pruritus, abnormal leucorrhea, chronic eczema, vagina peculiar smell, Trichomonas vaginalis, crab louse, leukoplakia vulvae, not only bring misery to the patient, and skin surface disease, also influence outward appearance U.S. of human body, bring stress to the patient.Methods of treatment can be divided into medicine for oral administration and externally applied drug.Medicine for oral administration is taken for a long time and is easy to damage other internal organs of human body, as liver, kidney, stomach etc.Externally applied drug has washing lotion (thimerosal), suppository etc. according to different syndromes.The thimerosal of selling in the market and using mainly is a chemical agent, and use is single, and what have can only be used as environment disinfected, the corrosion to equipment that has is very strong, as the Peracetic acid of present employing, concentration is big to have infringement to skin, and some disinfectant also has certain toxicity.
(3) summary of the invention
The technical problem to be solved in the present invention provides a kind of broad-spectrum bactericidal action that has, and skin and lesions position are not had injury, and has the disinfectant for external use of skin care effect.
The technical scheme that adopts is:
Disinfectant for external use is to be mixed by Chinese medical extract and Western medicine Ciprofloxacin lactate to be mixed with, and Chinese medical extract comprises Chinese medicine purslane extract, common cnidium fruit P.E, shrubby sophora extract, aloe extract, is powder.
Purslane extract, common cnidium fruit P.E, shrubby sophora extract, aloe extract, the Lactated compatibility of Ciprofloxacin are: purslane extract 7.5-30kg, common cnidium fruit P.E 7.5-30kg, shrubby sophora extract 5-20kg, aloe extract 5-20kg, Ciprofloxacin lactate 0.002-0.009kg.
The production method of purslane extract is:
Get the kitchen garden decontamination, input is washed and is added the water cleaning in the pond once, puts into Decocting pot after pulling out, adds clean water and covers powder, soaks 3-4 hour, adds suitable quantity of water again, and heating decocted 20-40 minute, got decoction liquor and deposited standby.In Decocting pot, add suitable quantity of water then and decoct secondary again, three decoction liquor obtaining are merged, place in the freezer and placed 24-48 hour down, take out and filter at 5-10 ℃, collect filtrate, till filtrate vacuum concentration to proportion is 1.05-1.10, atomized drying again, spray-dired EAT is 150-160 ℃, leaving air temp is 60-70 ℃, promptly get the purslane extract finished product, packing, the shady and cool dry place of sealing preserve, and be standby.
The production method of common cnidium fruit P.E is:
After getting the Chinese medicine frutus cnidii and removing its foreign material, put into Xi Chizhong and add the clean water cleaning once, pull and put into Decocting pot out, add water and cover powder, soaked 3-4 hour, heating decocted 20-40 minute, got decoction liquor, the same operation is secondary repeatedly, the decoction liquor that obtains for three times is merged, place in the freezer and placed 24-48 hour down, take out and filter at 5-10 ℃, filtrate vacuum concentration to proportion is 1.05-1.10, atomized drying again, EAT is 150-160 ℃, leaving air temp is 55-65 ℃, promptly get the common cnidium fruit P.E finished product, standby.
The production method of shrubby sophora extract is:
Getting kuh-seng soaked 3-4 hour, pull out and put into Decocting pot, supplementing water covers powder, heating decocted 20-40 minute, take out decoction liquor, the same operation three times repeatedly merges four gained decoction liquor, vacuum concentration to the stoste volume 1/3 after, in whipping process, add 95% ethanol to containing 70% concentration of alcohol, placed 24-48 hour, and removed by filter sediment, gained filtrate is carried out atomized drying, EAT is 155-165 ℃, leaving air temp is 55-65 ℃, promptly gets the shrubby sophora extract finished product, and is standby.
The manufacture method of aloe extract is:
Get fresh aloe, peeling is smashed to pieces evenly, hydraulic fluid filters, and collects filtrate, 1% adding decolorizing with activated carbon by weight refilters, and collects filtrate, vacuum concentration is about 1/10 of filtrate volume to be stopped to concentrate, with the concentrate atomized drying, EAT is 135-145 ℃, and leaving air temp is 50-60 ℃, promptly get the aloe extract finished product, standby.
Disinfectant for external use also can be made into washing lotion and makes instant effervescent tablet by pharmacy.
The manufacture method of disinfectant for external use washing lotion is:
Get kitchen garden, frutus cnidii, kuh-seng, aloe, Ciprofloxacin lactate by prescription, in continuous whipping process, add successively and be equipped with in the material-compound tank of an amount of distilled water, after treating whole medicine dissolutions, filter, in filtrate, add distilled water, make distilled water content be the medicine total amount 15-18 doubly, sampling chemical examination, qualified back packing.Can be distributed into 200mL/ bottle or 500mL/ bottle.
In the above-mentioned various formulations of disinfectant for external use, all can dose into an amount of aromatic.
The side separates:
1, the Chinese medicine kitchen garden is plant Portulaca oleraceal dry aerial parts.Contain multiple effective ingredient, as kitchen garden first, second element, coumarin etc. have effect clearing heat and detoxicating, treatment sore exanthema.
Spread on the Wound treating suppurative dermatosis outward, the various infection of surgery, bubble is washed the treatment impetigo, hip bath treatment private parts, perianal abscess, also has multiple pathogenic microorganism infection diseases such as eczema, joint are swollen, erysipelas, cellulitis, and effect is remarkable.
2, the Chinese medicine frutus cnidii is the dry mature fruit of plant Cnidium monieri (L.) Cuss, contain Osthole, firpene, amphene, volatile materials etc. have inhibitory action to multiple pathogenic microorganisms, trichomonad etc., as staphylococcus aureus, Pseudomonas aeruginosa, Trichomonas vaginalis etc.Be used for various human body skin infection, external genital infection, vaginitis, itch, gonorrhoea, trichomoniasis etc. better result of treatment is all arranged.
3, the Chinese medicine kuh-seng is the dry root of plant Sophora flavescens Ait.Contain multiple effective active components such as matrine, flavonoids.Escherichia coli, proteus, beta streptococcus, staphylococcus aureus, Pseudomonas aeruginosa all there are obvious inhibitory action, can kill trichomonas etc.Be used for various people's body surface pathogenic microorganism infections, vaginitis, gonorrhoea, cervical erosion etc. all have good efficacy.
4, the Chinese medicine aloe is the leaf of plant Aloe barbadensis Miller or Aferox Miller and homemade aloe Avera L.var.chinensis (HaW.) Berger, contain gelling class material, aloe J, aloe A, mucin (Mucin), Ah's Laue crow sieve (Aloe ulein), A Laomo chant in a loud voice effective ingredients such as (Alomiein), aloe polysaccharide.With the water-leach liquor test Escherichia coli, Pseudomonas aeruginosa, trichophyton mentagrophytes, dermatophyte etc. all there are inhibitory action, can also suppress herpes simplex virus and infection thereof.According to the literature, aloe can strengthen AIDS patient's immune system, the diffusion of blocking-up human immunodeficiency virus.Mechanism is and suppresses the synthetic of bacterial nucleic acid, and causing can not synthetic protein and make the bacterium can not growth and breeding.
Modern study shows that aloe is coated on the skin, can promote epithelial growth to subcutaneous infiltration, and non-viable non-apoptotic cell comes off, and the Skin Cell vigor is strengthened; Suppress oozing out of ulcer diffusate, the healing of accelerated in wounds is restored, and has and repairs and palingenesis.Therefore, apply body surface with aloe extract, can absorb heat anti-inflammatory, detumescence make Skin Cell become fresh soft, glossy, flexible, play the effect of skin care, like this, sterilization and skin care are combined, and be an innovation of people's body surface disinfectant, make something perfect even more perfect.
Among the people, common people directly control with aloe and burn, again Chinese aloe leaf " scald grass ", the remarkable result of treatment of visible aloe.
Above-mentioned four kinds of Chinese medicines are one edition one one of Chinese Pharmacopoeia 2000 and are written into medicinal material.
5, Ciprofloxacin (eiprofloxacin) is an extensive pedigree antibiotic.Has a good antibacterial action external, to citrobacter genus, cloaca, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, vibrio, Yersinia, gonococcus, Bacillus influenzae, pseudomonas, staphylococcus etc.To streptococcus pneumonia, hemolytic streptococcus, enterococcus faecalis etc., sand ring Chlamydia, mycoplasma, tubercle bacillus and anonymous mycobacteria etc. all there is antibacterial activity.As a kind of bactericide, now it is generally acknowledged the A subunit of drug effect in bacterial cell DNA enzyme, suppress the synthetic of DNA and duplicate and cause bacterium death.
Clinical practice is in urogenital infections, comprise simple property, complexity urinary tract infections, bacterial prostatitis, gonococcus urethritis or cervicitis, by infection, skin soft-tissue infection due to Shigella, Salmonella, enterotoxigenic escherichia coli, aeromonas hydrophila, the vibrio parahaemolytious etc., respiratory tract, bronchi and general infections such as pulmonary infection and septicemia.
Preparation has tablet, capsule and parenteral solution, with oral or drug administration by injection.
According to in-vitro antibacterial test, to do external application and people's body surface is killed or suppressed pathogenic microorganisms, washing, sterilization infection site can be brought into play quick-acting and therapeutic action.With drug matching, to maximize favourable factors and minimize unfavourable ones, synergy strengthens sterilizing ability, becomes an outstanding new disinfectant.
Ciprofloxacin is written into two ones of Chinese Pharmacopoeia versions in 2000.
Separate disinfectant for external use of the present invention as can be known according to above-mentioned side and select medicine and compatibility science, be applicable to the sterilization usefulness of human epidermal skin, vagina mucosa, ear schneiderian membrane, oral mucosa infection site, local burn and scald etc., have the function of sterilization, cleaning, treatment and skin care.
The present invention is for prevention and tool good results such as the various skin infections of treatment, sore rash, erysipelas, cellulitis, tinea pedis infection, eczema, itch, perianal abscess, vaginitis, cervical erosion, dripping property vaginitis, gonorrhoea.
Using method:
1, the washing lotion formulation usage of disinfectant for external use:
The skin surface infection can directly be cleaned with thimerosal, or soaks thimerosal with cotton balls and clean, and also available husky cloth soaks into this thimerosal soak affected part, and morning every day, evening are respectively once.
Disinfecting private parts with thimerosal cyclic washing of the present invention repeatedly or hip bath, soaked private parts 10-15 minute, every day early, evening each once.
Vagina mucosa sterilization is raised buttocks and with syringe thimerosal 20-30mL is injected in the vagina or with containing the thimerosal cotton balls and fasten a line, places in the vagina, and line is stayed outside the vagina, and early pull out cotton balls and get final product next day, every night once, and until recovery from illness.
The infection prevention venereal disease is used, and directly all can with thimerosal washing sexual organ of the present invention or immersion.
When 2, adopting powder, can adorn diffusing deposited infection place of pulvis, or be mixed with 5% aqueous solution, adopt above-mentioned washing lotion method to treat.
Quantitative disinfection test result:
Sample: the washing lotion formulation of disinfectant for external use
(1) materials and methods
Test organisms: Escherichia coli 8099, staphylococcus aureus Atec6538 is called for short colon bacillus, golden grape.
Test method:
Undertaken by " disinfection technology standard " method
(2) assay
Quantitative disinfection test result (suspension method)
Different (min) sterilizing rate action time (%) control groups of drug use
Bacterial strain concentration (%) 5 10 CFU/mL
Colon bacillus 10 99.9300 99.9800 5.50 * 10
6
Gold grape 10 99.9500 99.9900 6.00 * 10
6
Annotate: experimental condition: neutralizer is 1.0%, Tween 80+0.5 lecithin, cleaning temp 25 ℃ ± 1
3 repeated tests, bactericidal effect meets the requirements.
Disinfectant for external use of the present invention has been carried out a large amount of clinic trial, respond well.
Infecting 87 examples with treatment vaginal disease and people's body surface is that example is explained as follows external application disinfectant result of treatment:
1, case is selected
The female patient of diplococcus, herpes simplex viral infections, private parts communicable disease are selected in human trial.
(1) a large amount of purulence sample leukorrhea body odor flavors is arranged in the vagina;
(2) microscopically is found gram-negative diplococci;
(3) the infected who has is with the pain of lower abdomen or pain in the back etc.
2, methods of treatment
Every day 1-2 time, to infection site, sterilization, observation is treated in washing and soak etc., general 1-7 time.
3, effect is judged
Drug withdrawal was observed after 4 days.
(1) recovery from illness vagina and cunnus hyperraemia disappear, and purulent leukorrhea disappears, and stink disappears;
(2) produce effects vagina and cunnus hyperraemia disappear or obviously alleviate, and purulent leukorrhea transfers white to, only a small amount of rare white leukorrhea, and stink disappears;
(3) effectively vagina and cunnus hyperraemia alleviate, and the leukorrhea amount reduces, and it is shallow that look changes, and stink obviously alleviates;
(4) invalid sign is little with preceding no change of treatment or variation.
4, treatment results
30 examples, women, 19-35 year wherein, 28 examples, 45 years old 1 example, 50 years old 1 example.5 examples of fully recovering, cure rate is 83%, produce effects 4 examples, obvious effective rate is 13%, effective 1 example, efficient is 4%.Total effective rate is 100%.
People's body surface infects, as pustular eruption, and herpes zoster, tinea pedis infection etc. are cleaned or the soak affected part with disinfectant of the present invention, 1-2 week, treat 57 examples, male 25 examples, women's 32 examples, 52 examples of fully recovering, produce effects 5 examples, total effective rate is 100%.
The advantage of disinfectant for external use:
1, this disinfectant adopts Chinese and Western medicine optimum organization, and sterilizing power is strong, fast, and wider antimicrobial spectrum is arranged.
2, this disinfectant is specifically designed to the sterilization of people's body surface, kills the pathogenic microorganisms on the body surface or suppresses viral growth and breeding, prevents the infringement of pathogene to body surface or infection site, can reach the effect of prevention and treatment;
3, this disinfectant contains plant gel class material, can make washing agent, cleans infection site, quickens the reparation of damage and the effect of protection skin, is the collection sterilization, and treatment is cleaned and skin care is the novel body-building disinfectant of one;
4, this disinfectant nonirritant, corrosivity and toxicity; Stability might as well;
5, mature production technology, equipment investment is few, and raw material is easy to get, and price is suitable.
(4) embodiment
Embodiment one
Disinfectant for external use is to be mixed and be mixed with by purslane extract 15kg, common cnidium fruit P.E 15kg, shrubby sophora extract 10kg, aloe extract 10kg, Ciprofloxacin lactate 0.006kg, is powder.
Embodiment two
The washing lotion formulation of disinfectant for external use be by:
Purslane extract 15kg, common cnidium fruit P.E 15kg, shrubby sophora extract 10kg, aloe extract 10kg, Ciprofloxacin lactate 0.006kg add 949.994kg distilled water and are mixed with.
Specification:
(1) washing lotion formulation 200mL/ bottle, 500mL/ bottle
(2) powder 6g/ bag, 10g/ bag.
Claims (3)
1, disinfectant for external use, be to mix by Chinese medical extract and Western medicine Ciprofloxacin lactate to be mixed with, it is characterized in that described Chinese medical extract comprises Chinese medicine purslane extract, common cnidium fruit P.E, shrubby sophora extract, aloe extract, its compatibility is: purslane extract 7.5-30kg, common cnidium fruit P.E 7.5-30kg, shrubby sophora extract 5-20kg, aloe extract 5-20kg, Ciprofloxacin lactate 0.002-0.009kg.
2, disinfectant for external use according to claim 1 is characterized in that being mixed with by purslane extract 15kg, common cnidium fruit P.E 15kg, shrubby sophora extract 10kg, aloe extract 10kg, Ciprofloxacin lactate 0.006kg.
3, disinfectant for external use according to claim 2 is characterized in that adding 949.994kg distilled water, makes washing lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031333915A CN1191066C (en) | 2003-05-27 | 2003-05-27 | Externally-used disinfector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031333915A CN1191066C (en) | 2003-05-27 | 2003-05-27 | Externally-used disinfector |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1462584A true CN1462584A (en) | 2003-12-24 |
| CN1191066C CN1191066C (en) | 2005-03-02 |
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ID=29748499
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031333915A Expired - Fee Related CN1191066C (en) | 2003-05-27 | 2003-05-27 | Externally-used disinfector |
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| Country | Link |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543467B (en) * | 2009-04-01 | 2010-12-29 | 完美（中国）日用品有限公司 | Aloe gel and preparation method thereof |
| CN102986665A (en) * | 2012-11-29 | 2013-03-27 | 陈容太 | Method for preparing chemical sanitizer |
| CN102986666A (en) * | 2012-11-29 | 2013-03-27 | 陈容太 | Chemical sanitizer |
| CN103690698A (en) * | 2013-11-26 | 2014-04-02 | 安徽三超药业有限公司 | Broad-spectrum antibacterial cream |
| CN107853332A (en) * | 2017-09-20 | 2018-03-30 | 连云港柘达消毒科技有限公司 | A kind of environment-friendly high-efficiency disinfectant |
-
2003
- 2003-05-27 CN CNB031333915A patent/CN1191066C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543467B (en) * | 2009-04-01 | 2010-12-29 | 完美（中国）日用品有限公司 | Aloe gel and preparation method thereof |
| CN102986665A (en) * | 2012-11-29 | 2013-03-27 | 陈容太 | Method for preparing chemical sanitizer |
| CN102986666A (en) * | 2012-11-29 | 2013-03-27 | 陈容太 | Chemical sanitizer |
| CN103690698A (en) * | 2013-11-26 | 2014-04-02 | 安徽三超药业有限公司 | Broad-spectrum antibacterial cream |
| CN107853332A (en) * | 2017-09-20 | 2018-03-30 | 连云港柘达消毒科技有限公司 | A kind of environment-friendly high-efficiency disinfectant |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1191066C (en) | 2005-03-02 |
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