CN1189206C

CN1189206C - Medicine for curing leuconychia and hand-foot ringworm and preparing method thereof

Info

Publication number: CN1189206C
Application number: CNB031181864A
Authority: CN
Inventors: 彭祥林
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-03-20
Filing date: 2003-03-20
Publication date: 2005-02-16
Anticipated expiration: 2023-03-20
Also published as: CN1454656A

Abstract

The present invention relates to a traditional Chinese medicine and preparation technique, particularly to a medicine for curing onychomycosis and hand-foot ringworm and a preparing method thereof. The present invention has the solution proposal that disinfecting liquid extracted from natural plants is developed by combining long term research with folk experience in a strict and scientific recipe and a technological process. The product has favorable sterilizing action on staphylococcus aureus and candida albicans. The present invention is composed of the following components and the method (the content of the following components measured by the weight percentage): 5 to 30% of garlic, 5 to 20% of pseudolarix barks, 5 to 20% of cloves, 2 to 10% of fructus cnidii, 2 to 15% of flavescent sophora roots and 5 to 40% of glacial acetic acid. The liquid medicine of the present invention, which is made from the components by a strict process and is suitable for the treatment for onychomycosis and hand-foot ringworm infected by various kinds of pathogenic fungus, can improve cure effect and shorten cure period. Beside, the medicine for curing onychomycosis and hand-foot ringworm has the characteristics of prevention and through cure.

Description

Medicine of treatment tinea unguium, tinea manus and pedis and preparation method thereof

Technical field

The present invention relates to Chinese medicine and technology of preparing, refer in particular to medicine of treatment tinea unguium, tinea manus and pedis and preparation method thereof.

Background technology

Tinea unguium is by fungus-caused a kind of commonly encountered diseases frequently-occurring disease, and preventing and kill fungal infection also is an important topic of current research.According to incompletely statistics, very high in China because of the tinea manus and pedis infection rate that fungal infection causes.Southern area can reach 50%-60%, and the north also reaches 40%-50%, and some special professional infection rates can reach 80%-100%, and the untimely prevention of fungus that shallow table infects or kill can cause the deep skin infection.Thereby the fungus that infects tinea unguium will more be difficult to kill, and bring work, life, social inconvenience to the patient.At present, not thorough, the easy recurrence of introducing in medicine on the market and the books and periodicals of Therapeutic Method existence treatment, the shortcoming of treatment cycle length.It is main material that Chinese patent application number 00113671.2 disclosed medicine adopts Flos Caryophylli, Radix Sophorae Flavescentis etc., preparation through high temperature, high pressure extract, active ingredient is once to destroy to High Temperature High Pressure to Chinese crude drug theoretically, and problem such as this method lixiviate production cycle is long, difficult quality control and cause product quality defect.

Summary of the invention

The objective of the invention is to be improved at shortcoming in the background technology and problem, provide a kind of treatment cycle short, therapeutic effect is good, the treatment tinea unguium that does not recur, medicine of tinea manus and pedis and preparation method thereof.

Solution of the present invention is by long-term exploration, in conjunction with experience among the people, scientific formula and technological process with strictness, develop the disinfectant solution that from natural plants, extracts, this product has good virus killing effect to staphylococcus aureus, Candida albicans, realizes (content of following each component all is weight percentage) by following prescription and method:

Bulbus Allii 5～30, Cortex Pseudolaricis 5～20, Flos Caryophylli 5～20, Fructus Cnidii 2～10

Radix Sophorae Flavescentis 2～15, glacial acetic acid 5～40.

Preparation method of the present invention is:

1) feed intake in proportion, medical material is cleaned or moistening, add 8～10 times in water to extraction pot, 100 ℃ were refluxed 5 hours;

2) with the extracting solution cooling, filter, standby;

3) with the Bulbus Allii peeling, smash to pieces, join in the extracting solution, temperature must not be above 35 ℃;

4) extracting solution of adding Bulbus Allii, hydrolysis 48 hours is regularly stirred;

5) liquid after the hydrolysis is added glacial acetic acid to PH=3 ± 1;

6) precipitation of the medicinal liquid after will preparing is 12～24 hours, and product of the present invention is made in fill.

Tinea unguium due to the various pathomycetes of a kind of suitable treatment that the present invention is made up of above-mentioned prescription and strict process is produced infect, the liquid pharmaceutical formulation of tinea manus and pedis can improve curative effect, the characteristics that shorten the healing cycle and prevention is arranged and thoroughly cure.

In this present invention's the compatibility, but active ingredient kill bacteria and fungus in Flos Caryophylli and the garlicin, and traditional kill bacteria and the glacial acetic acid of fungus can have very strong permeability.By above active ingredient scientific compatibility and the advanced production technology of employing, our company development showed can be efficiently the thorough disinfectant solution of kill bacteria, fungus, this disinfectant solution porous is in the thalline that causes a disease, make tropina solidify degeneration, disturb the activity of bacterium enzyme, suppress metabolism and the production of pathogenic bacterium, change the cell permeability of the membrane and destroy its physiological function and play sterilization.Through the Disinfection Effect test, this venom can thoroughly be killed staphylococcus aureus, escherichia coli, Candida albicans etc.

Pharmacological action of the present invention:

Bulbus Allii: contain alliin in the Bulbus Allii, be subjected to the effect of big allinase, hydrolysis produces allicin, and allicin has inhibition and kills the fungus effect;

Glacial acetic acid: low concentration, permeability is strong, destroys the fungus living environment, and plays bactericidal action;

Cortex Pseudolaricis: native rose of Sharon sour soil rose of Sharon severe edema due to hypofunction of the spleen extract is to the effect of pathomycete bacteriostasis and sterilization;

Flos Caryophylli: the Main Ingredients and Appearance eugenol has significantly antibiotic, antifungic action;

Radix Sophorae Flavescentis: Main Ingredients and Appearance, matrine has in various degree inhibition, killing action to common dermatophytes;

Fructus Cnidii: Main Ingredients and Appearance, ethereal oil has antifungic action.

The specific embodiment

Mode one

Get Bulbus Allii 6, Cortex Pseudolaricis 6, Flos Caryophylli 6, Fructus Cnidii 3, Radix Sophorae Flavescentis 3, glacial acetic acid 6 feeds intake in proportion, and is medical material is clean or moistening, add 8 times in water to extraction pot, and 100 ℃ were refluxed 5 hours; With the extracting solution cold filtration, standby; With the Bulbus Allii peeling, smash to pieces, join in the extracting solution 30 ℃ of temperature; The extracting solution that adds Bulbus Allii, hydrolysis 48 hours is regularly stirred; Liquid after the hydrolysis is added glacial acetic acid to PH=3 ± 1; Medicinal liquid after the preparation is precipitated 15 hours, and product of the present invention is made in fill.

Mode two:

Get Bulbus Allii 17.5, Cortex Pseudolaricis 12.5, Flos Caryophylli 12.5, Fructus Cnidii 6, Radix Sophorae Flavescentis 8.5, glacial acetic acid 22.5 feeds intake in proportion, and is medical material is clean or moistening, add 9 times in water to extraction pot, and 100 ℃ were refluxed 5 hours: with the extracting solution cold filtration, standby; With the Bulbus Allii peeling, smash to pieces, join in the extracting solution 33 ℃ of temperature; The extracting solution that adds Bulbus Allii, hydrolysis 48 hours is regularly stirred; Liquid after the hydrolysis is added glacial acetic acid to PH=3 ± 1; Medicinal liquid after the preparation is precipitated 20 hours, and product of the present invention is made in fill.

Mode three:

Get Bulbus Allii 29, Cortex Pseudolaricis 19, Flos Caryophylli 19, Fructus Cnidii 9, Radix Sophorae Flavescentis 14, glacial acetic acid 39 feeds intake in proportion, and is medical material is clean or moistening, add 10 times in water to extraction pot, and 100 ℃ were refluxed 5 hours: with the extracting solution cold filtration, standby; With the Bulbus Allii peeling, smash to pieces, join in the extracting solution 35 ℃ of temperature; The extracting solution that adds Bulbus Allii, hydrolysis 48 hours is regularly stirred; Liquid after the hydrolysis is added glacial acetic acid to PH=3 ± 1; Medicinal liquid after the preparation is precipitated 24 hours, and product of the present invention is made in fill.

Invention detects through Hunan Hygienic ﹠ Epidemic Prevention Station, and potent bactericidal effect is arranged, and can reach the purpose of preventing and killing fungus, and any toxicity not occur.Its bactericidal effect is seen attached list.

Subordinate list:

Table 1: the present invention is to the killing effect of staphylococcus aureus

Disinfectant dilution factor (V/V) stoste 1: l 1: 2	The average kill ratio and the scope (%) of effect different time (min)	Bacterium average and scope (cfu/ sheet) 2.12 * 10 that matched group reclaims ⁶(2.04×10 ⁶-2.48×10 ⁶)
			1 3 5 10 99.97 100.00 100.00 100.00 (99.95-99.98) (100.00) (100.00) (100.00) 99.95 100.00 100.00 100.00 (99.93-99.96) (100.00) (100.00) (100.00) 97.38 99.68 99.94 100.00 (97.24-97.45) (99.50-99.72) (99.92-99.96) (100.00)

Annotate: 1, negative control asepsis growth; 2, the test water temperature is 20 ± 1 ℃; 3, the test triplicate is got average.

Table 2: the present invention is to colibacillary killing effect

Disinfectant dilution factor (V/V) stoste 1: 11: 2	The average kill ratio and the scope (%) of effect different time (min)	Bacterium average and scope (cfu/ sheet) 1.60 * 10 that matched group reclaims ⁶(1.40×10 ⁶-1.72×10 ⁶)
			1 3 5 10 100.00 100.00 100.00 100.00 (100.00) (100.00) (100.00) (100.00) 100.00 100.00 100.00 100.00 (100.00) (100.00) (100.00) (100.00) 99.81 99.92 99.97 100.00 (99.78-99.86) (99.91-99.94) (99.94-99.98) (100.00)

Table 3: the present invention is to the oidiomycetic killing effect of white

Disinfectant dilution factor (V/V) stoste 1: 11: 2	The average kill ratio and the scope (%) of effect different time (min)	Bacterium average and scope (cfu/ sheet) 3.68 * 10 that matched group reclaims ⁶(3.46×10 ⁶-3.72×10 ⁶)
			1 3 5 10 99.99 100.00 100.00 100.00 (99.99) (100.00) (100.00) (100.00) 99.98 100.00 100.00 100.00 (99.96-99.99) (100.00) (100.00) (100.00) 99.78 99.91 99.95 100.00 (99.70-99.85) (99.90-99.98) (99.92-99.96) (100.00)

Claims

1, a kind of medicine for the treatment of tinea unguium, tinea manus and pedis is characterized in that it is made by following raw materials by weight percent:

Radix Sophorae Flavescentis 2～15, glacial acetic acid 5～40.

2, the preparation method of medicine according to claim 1 is characterized in that:

1) feed intake in proportion, medical material is clean or moistening, add 8～10 times in water to extraction pot, 100 ℃ were refluxed 5 hours;

2) with the extracting solution cold filtration, standby;

5) liquid after the hydrolysis is added glacial acetic acid to PH=3 ± 1;