CN105997688B - A kind of natural plant extracts for keeping senile skin health moist and preparation method and purposes - Google Patents
A kind of natural plant extracts for keeping senile skin health moist and preparation method and purposes Download PDFInfo
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- CN105997688B CN105997688B CN201610493186.8A CN201610493186A CN105997688B CN 105997688 B CN105997688 B CN 105997688B CN 201610493186 A CN201610493186 A CN 201610493186A CN 105997688 B CN105997688 B CN 105997688B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
It is to extract to obtain from the plant composition being made of each raw material of following parts by weight the invention discloses a kind of natural plant extracts and preparation method that holding senile skin health is moist and purposes, the natural plant extracts of the invention: 10~50 parts by weight of dendrobium nobile, 10~30 parts by weight of armeniaca mume, 10~20 parts by weight of rosemary, 1~30 parts by weight of 5~30 parts by weight of chamomile, 1~20 parts by weight of paniculate swallowwort and waltheria indica.It is experimentally confirmed that product of the present invention is non-stimulated to skin safe, and simultaneously being capable of maintenance skin barrier, with instant, long-acting supplement moisture of skin, prevent moisture loss, the effect for promoting skin microcirculation, it is moist, pale soft using rear turgor, thus the effect of reaching beauty and skin care.In addition, raw material of the present invention obtain be easy, preparation method it is easy, it is green safe, have a good application prospect and market prospects.
Description
Technical field
The present invention relates to a kind of external natural plant extracts, in particular to a kind of for keeping senile skin health to moisten
External natural plant extracts and preparation method thereof, further relate to the external-use skin care preparation being prepared by the plant extracts.
The invention belongs to cosmetics studying technological domains.
Background technique
In human aging process, it is easy to directly result in the elderly for the variation of skin keratin process and Stratum corneum lipids content
Suffer from xerosis.Keratinization is a homeostasis process, and keratinocyte is migrated from basal layer to be risen and be flattened into angle
Cell plastid, on the other hand, horn cell fall off from skin with the death of cell.Occur any problem in this balance all can
Lead to the increase of furfur and the feeling of dry skin.Further, since cell ageing, the lipoprotein membrane of horn cell and intercellular
Connection is destroyed, and then, the barrier function of skin is gradually withered away.Solve the problems, such as that dry skin is the pass of elderly population skin nursing
Key.
Sufficient moisture can make the well-regulated reflection of skin cuticula and form bright gloss, and dry, have the scales of skin that peel off
Cuticula in the form of non-mirror reflection reflection light, make gloomy skin.Skin moisture content is sufficient, can also repair skin
The physiological functions such as barrier, the absorption of enhancing skin, metabolism are to preferably protect skin.
In recent years, additive of the natural plant extracts as beauty and skin care cosmetics has stable and durable effect, shows
Write, to skin action temperature and and the advantages such as safety height, thus, consumer more favor made of refinement in natural plants
Natural type green moisturizer.But the excellent natural moisturizer of performance of keeping humidity can not specific aim solution the elderly's dry skin at present
Problem.Based on this, the present invention is directed to the elderly's skin characteristic, from the mechanism for causing the dry symptom of the elderly, by dendrobium nobile, green
Calyx plum, rosemary, chamomile, paniculate swallowwort and waltheria indica are by scientific composition compounding into a kind of with moisturizing effect
External natural plant extracts promotes skin metabolism studies have shown that dry skin symptom can be effectively relieved in the extract, thus
Reach the effect of nourishing moisturizing.
Summary of the invention
One of the objects of the present invention is to provide a kind of external natural plant groups for keeping senile skin health moist
Close object.
The second object of the present invention, which is to provide, a kind of keeps old skin by having of being prepared of above-mentioned plant composition
Skin health moistens the plant extracts of effect.
The third object of the present invention is to provide a kind of skin care formulation being prepared based on above-mentioned natural plant extracts.
In order to achieve the above object, present invention employs following technological means:
The present invention utilizes advanced biotechnology, in conjunction with the theory of traditional Chinese medical science of Chinese tradition, by dendrobium nobile, armeniaca mume, rosemary,
Chamomile, paniculate swallowwort, waltheria indica are effectively combined in together, and decide its dosage, so that compound is formed, in addition, the present invention will
Its extract is prepared into skin care formulation as active component, it is demonstrated experimentally that the extract or the skin care formulation being prepared by it
There is significant moisturizing effect for skin, especially senile skin.Above-mentioned each plant component is described as follows:
Dendrobium nobile: alias Lin Lan, prohibition of life, Du Lan, stone Weed, outstanding bamboo, thousand Nian Zhu.It is sweet；It is slightly cold, stomach；Lung；Kidney channel.Can promote the production of body fluid benefit
Stomach；Nourishing Yin and clearing heat；Moistening lung kidney-nourishing；The strong waist of improving eyesight.
Armeniaca mume: mild-natured, taste is slightly sour.Return liver, stomach, lung channel.There is out the effect of Yu Hezhong, resolving sputum, removing toxic substances.
Rosemary: for the herb of Lamiaceae plant rosemary.Acrid flavour；It is warm-natured.It can calm the nerves；Analgesic.
Chamomile: it is cool in nature, it is sweet in flavor, bitter, enter lung, Liver Channel.With dispelling wind, the effect of heat-clearing, calming the liver, improving eyesight, removing toxic substances.
Paniculate swallowwort: acrid in flavour and warm in nature.Return liver, stomach meridian.Originate in the ground such as Liaoning, the Inner Mongol, Shanxi, Hebei, Henan, Shaanxi.
Waltheria indica: pungent；Micro-sweet；It is slightly cold；Expelling wind and removing dampness；It is clearing heat and detoxicating.Taiwan, Fujian, Guangdong, Guangxi, Yunnan etc. is produced to save
The south in area.
Specifically, a kind of external natural plant composition for keeping senile skin health moist of the invention, by
Each raw material of following parts by weight forms: 10~50 parts by weight of dendrobium nobile, 10~30 parts by weight of armeniaca mume, 10~20 weight of rosemary
Part, 1~30 parts by weight of 5~30 parts by weight of chamomile, 1~20 parts by weight of paniculate swallowwort and waltheria indica.
In the present invention, it is preferred to, the external natural plant composition is made of each raw material of following parts by weight: stone
35 parts by weight of dry measure used in former times, 10 parts by weight of armeniaca mume, 15 parts by weight of rosemary, 30 parts by weight of chamomile, 14 parts by weight of paniculate swallowwort and snake
1 parts by weight of woman.
In addition, the invention also provides a kind of external natural plant extracts for keeping senile skin health moist,
It is prepared by the following method to obtain by above-described plant composition:
(1) after each raw material crushes, each raw material is weighed according to parts by weight of the present invention, is mixed；
(2) mass ratio of extracting in water, raw material and water is 10~30:150~350, and 60 DEG C~100 DEG C extractions 1~4 are small
When；
(3) extracting solution that step (2) obtains is cooled to 20~30 DEG C, the filtering of 100~200 mesh carries out after filtering out residue
Vacuum filtration, collect filtrate to get.
In the present invention, it is preferred to, the mass ratio of raw material and water is 15~25:180~200 in step (2).
In the present invention, it is preferred to, vacuum filtration described in step (3), which is included in Buchner funnel, spreads two layers of filter paper,
The diatomite of folder 0.3~0.6cm thickness, is then filtered by vacuum among filter paper.
Further, the invention also provides above-described external natural plant extracts to prepare external-use skin care preparation
In purposes, wherein it is preferred, the external-use skin care preparation have moisturizing, improve skin roughness, improve the colour of skin with
And the effect of improving skin microcirculation.
A kind of external-use skin care preparation for keeping senile skin health moist of the invention, by above-described external application
Natural plant extracts and skin care field customary adjuvant are made.
Specifically, The present invention gives a kind of creams for keeping senile skin health moist, by A phase, B phase, C phase
And D phase composition；
Wherein, the A phase includes PEG-100 stearine/stearine, dimethyl silicone polymer, season
Penta tetrol distearate, isononyl isononanoate, jojoba oil, isopropyl myristate, cetostearyl alcohol, Queensland nut seed
Oil, Parleam, VE acetate and caprylic/capric triglyceride；
Wherein, the B phase includes carbomer, glycerol, xanthan gum, butanediol, oat beta glucan, EDETATE SODIUM, beet
Alkali and water；
Wherein, the C phase includes acrylamide/ammonium acrylate copolymer/polyisobutene/polysorbate -20；
Wherein, the D phase includes external natural plant extracts and preservative of the present invention；
Wherein, the mass percentage of each raw material is as follows:
Wherein, it is preferred that the mass percentage of each raw material is as follows:
In the present invention, it is preferred to, a kind of described cream for keeping senile skin health moist, be according to
Lower section method is prepared:
(1) B phase: butanediol, glycerol, carbomer and xanthan gum are mixed, stirred evenly, for use；Other raw materials of B phase add
Enter in water, be stirring evenly and then adding into the mixture of butanediol, glycerol, carbomer and xanthan gum, be heated to 80~85 DEG C, mixes
It is even；
(2) A phase: A phase raw material is separately heated to 80~85 DEG C, mixes；
(3) step (2) A phase is all added in step (1) B phase, 2000~3000r/min, homogeneous 5min~
10min；Acrylamide/ammonium acrylate copolymer/polyisobutene/polysorbate -20,2000~3000r/min, homogeneous is added
1~3min；30~50r/min after stirring 5~10min, starts stirring cooling, 30~50r/min of stirring rate, rate of temperature fall
For 1~2 DEG C/min；
(4) when temperature drops to 45~50 DEG C, preservative and external natural plant extracts is added, stirs evenly, continue
40 DEG C are cooled to hereinafter, to obtain the final product.
According to using approach different, plant extraction liquid is obtained after external natural plant composition of the present invention is extracted, also
It can be made into other external-use skin care preparations, such as lotion, toner, facial mask, but be not limited to above-mentioned dosage form, it can be according to cosmetics work
A variety of different external preparations are made in known method in industry field.
The preparation method of plant composition of the present invention is not limited to of the present invention, other in the art conventional methods can also
Realize that described effect, the method for the present invention are that inventor recommends preferable preparation method.Ingredient of the cream of the present invention in addition to extract is simultaneously
Unconventional auxiliary material is formulated between each component for the optimum formula that inventor obtains through creative work and cooperates with action.
Invention formulation is recommended to use method are as follows: after daily face cleaning, imposes on human skin surface with smearing method, gently presses
It rubs until absorbing.
Finally, the invention also provides the creams in skin moisture-keeping, improvement skin roughness, the improvement colour of skin and to change
Purposes in kind skin microcirculation, it is preferred that the cream is more suitable for the elderly.
Compared to the prior art, beneficial outcomes of the invention are as follows:
It is experimentally confirmed that product of the present invention is non-stimulated to skin safe, and simultaneously can maintenance skin barrier, have immediately,
Long-acting supplement moisture of skin prevents moisture loss, the effect for promoting skin microcirculation, accelerating skin metabolism, after use
Turgor is moist, pale soft, thus the effect of reaching beauty and skin care.In addition, raw material of the present invention obtain easy, preparation side
Method is easy, green safe, has a good application prospect and market prospects.
Detailed description of the invention
Fig. 1 is sample hydration rate test result；
Fig. 2 is sample percentage of water loss test result；
Fig. 3 is skin coloration change rate result；
Fig. 4 is skin infrared thermal imaging result.
Specific embodiment
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.But examples are merely exemplary, and it is not intended to limit the scope of the present invention in any way.Those skilled in the art answer
It should be appreciated that without departing from the spirit and scope of the invention can details to technical solution of the present invention and form repair
Change or replace, but these modifications and replacement are fallen within the protection scope of the present invention.
Plant material used in the present embodiment can be commercially available from China Medicament Group Corp., meet Chinese people's republicanism
2010 editions standards of state's pharmacopeia.Other raw materials can be obtained by commercially available purchase, and the present invention is shown in Table 1 using the source of raw material, this hair
Bright instrument title and producer used are shown in Table 2.
Table 1
Table 2
The preparation of the external natural plant extracts of the present invention of embodiment 1
(1) after crushing dendrobium nobile, armeniaca mume, rosemary, chamomile, paniculate swallowwort, waltheria indica respectively, according to following weight point
Each raw material: dendrobium nobile 35g, armeniaca mume 10g, rosemary 15g, chamomile 30g, paniculate swallowwort 14g, waltheria indica 1g is also known as taken, mixing is equal
It is even；
(2) mass ratio of extracting in water, raw material and water is 20:200, and 60 DEG C are extracted 2 hours；
(3) extracting solution that step (2) obtains is cooled to 30 DEG C, the filtering of 100~200 mesh carries out very again after filtering out residue
Empty pump filter, the vacuum filtration, which is included in Buchner funnel, spreads two layers of filter paper, the diatomite of folder 0.5cm thickness among filter paper, so
After be filtered by vacuum, collect filtrate to get.
The preparation of the external natural plant extracts of the present invention of embodiment 2
(1) after crushing dendrobium nobile, armeniaca mume, rosemary, chamomile, paniculate swallowwort, waltheria indica respectively, according to following weight point
Each raw material: dendrobium nobile 50g, armeniaca mume 30g, rosemary 10g, chamomile 15g, paniculate swallowwort 1g, waltheria indica 20g is also known as taken, mixing is equal
It is even；
(2) mass ratio of extracting in water, raw material and water is 10:350, and 100 DEG C are extracted 4 hours；
(3) extracting solution that step (2) obtains is cooled to 20 DEG C, the filtering of 100~200 mesh carries out very again after filtering out residue
Empty pump filter, the vacuum filtration, which is included in Buchner funnel, spreads two layers of filter paper, the diatomite of folder 0.6cm thickness among filter paper, so
After be filtered by vacuum, collect filtrate to get.
The preparation of the external natural plant extracts of the present invention of embodiment 3
(1) after crushing dendrobium nobile, armeniaca mume, rosemary, chamomile, paniculate swallowwort, waltheria indica respectively, according to following weight point
Each raw material: dendrobium nobile 10g, armeniaca mume 20g, rosemary 20g, chamomile 5g, paniculate swallowwort 20g, waltheria indica 30g is also known as taken, mixing is equal
It is even；
(2) mass ratio of extracting in water, raw material and water is 30:150, and 80 DEG C are extracted 1 hour；
(3) extracting solution that step (2) obtains is cooled to 25 DEG C, the filtering of 100~200 mesh carries out very again after filtering out residue
Empty pump filter, the vacuum filtration, which is included in Buchner funnel, spreads two layers of filter paper, the diatomite of folder 0.3cm thickness among filter paper, so
After be filtered by vacuum, collect filtrate to get.
The preparation of the cream of the present invention of embodiment 4
1, component and dosage:
It is as shown in table 3 below:
Table 3
2, preparation method:
(1) B phase: butanediol, glycerol, carbomer and xanthan gum are mixed, stirred evenly, for use；Other raw materials of B phase add
Enter in water, be stirring evenly and then adding into the mixture of butanediol, glycerol, carbomer and xanthan gum, be heated to 83 DEG C, mixes；
(2) A phase: A phase raw material is heated to 80 DEG C, mixes；
(3) the A phase of step (2) is all added in the B phase of step (1), 2000r/min, homogeneous 7min；Propylene is added
Amide/ammonium acrylate copolymer/polyisobutene/polysorbate -20 (C phase), 2000r/min, homogeneous 3min；40r/min is stirred
After mixing 10min, start stirring cooling, stirring rate 30r/min, rate of temperature fall is 1~2 DEG C/min；
(4) when temperature drops to 45 DEG C, the external natural plant extracts (D that preservative and embodiment 1 are prepared is added
Phase), it stirs evenly, continues to be cooled to 40 DEG C hereinafter, to obtain the final product.
The preparation of the cream of the present invention of embodiment 5
1, component and dosage:
It is as shown in table 4 below:
Table 4
2, preparation method:
(1) B phase: butanediol, glycerol, carbomer and xanthan gum are mixed, stirred evenly, for use；Other raw materials of B phase add
Enter in water, be stirring evenly and then adding into the mixture of butanediol, glycerol, carbomer and xanthan gum, be heated to 80 DEG C, mixes；
(2) A phase: A phase raw material is heated to 83 DEG C, mixes；
(3) the A phase of step (2) is all added in the B phase of step (1), 2500r/min, homogeneous 5min；Propylene is added
Amide/ammonium acrylate copolymer/polyisobutene/polysorbate -20 (C phase), 3000r/min, homogeneous 1min；50r/min is stirred
After mixing 7min, start stirring cooling, stirring rate 50r/min, rate of temperature fall is 1~2 DEG C/min；
(4) when temperature drops to 50 DEG C, the external natural plant extracts (D that preservative and embodiment 2 are prepared is added
Phase), it stirs evenly, continues to be cooled to 40 DEG C hereinafter, to obtain the final product.
The preparation of the cream of the present invention of embodiment 6
1, component and dosage:
It is as shown in table 5 below:
Table 5
2, preparation method:
(1) B phase: butanediol, glycerol, carbomer and xanthan gum are mixed, stirred evenly, for use；Other raw materials of B phase add
Enter in water, be stirring evenly and then adding into the mixture of butanediol, glycerol, carbomer and xanthan gum, be heated to 80 DEG C, mixes；
(2) A phase: A phase raw material is heated to 85 DEG C, mixes；
(3) the A phase of step (2) is all added in the B phase of step (1), 3000r/min, homogeneous 10min；It is added third
Acrylamide/ammonium acrylate copolymer/polyisobutene/polysorbate -20 (C phase), 2500r/min, homogeneous 2min；30r/min,
After stirring 5min, start stirring cooling, stirring rate 40r/min, rate of temperature fall is 1~2 DEG C/min；
(4) when temperature drops to 47 DEG C, the external natural plant extracts (D that preservative and embodiment 3 are prepared is added
Phase), it stirs evenly, continues to be cooled to 40 DEG C hereinafter, to obtain the final product.
The effect of test example product of the present invention, tests
One, moistening effect is evaluated
1, moistening effect --- human skin keratinocyte's layer hydration rate test
(1) test method
Test crowd is 50 Chinese women more than one full year of life of skin health, amounts to 8 people, and subject, which tests first 3 days, to stop
Use skin-protection product.
Test position: on the inside of subject cranks arm.It at palm base portion 5cm, marks tested region (4cm × 4cm), on the other hand
Arm can mark multiple regions (interval 1cm), the equal random distribution of test sample simultaneously.
Test sample: 1# control group is bare substrate (matrix formulations are shown in Table 3, and do not contain plant extracts)；2# experiment
Group is cream prepared by embodiment 4.
Subject's Profile is established, and volunteer is required to fill in informed consent form, staff carries out instrument and test
Environment debugging；22 ± 2 DEG C of temperature, relative humidity 50% ± 5%；Subject reaches testing location, cleans recipient site, wipes only,
Sit quietly 20min；
Using circulation double blind label；
Test starts, and this time is 0 timing, acquires subjects skin's background values, and be denoted as T0；By technical staff by
It tries position and smears sample, and timing；Data acquisition is carried out in 1h, 2h, 4h respectively.
To understand and handling subject in time using the adverse reaction being likely to occur after sample or reference material, during test by
Examination person can react tested region sense of discomfort at any time, when such as there is the skin irritatin of apparent systemic adverse reactions or 3 grades or more, answer
Termination test immediately, and subject is suitably treated.
(2) data are analyzed
Apparatus measures evaluation: it is examined using t and Statistics Division is carried out to the numerical value change for using the every measurement index in product front and back
Reason, is made whether effective conclusion according to calculated result.
(3) experimental result
Do not occur the skin irritatin of apparent systemic adverse reactions or 3 grades or more within test period, in tested crowd, therefore
Effective volunteer's number of this test is 8 people.
Moisture content of skin MMV:
△=Tn-T0
Hydration rate=(Tn—T0)/T0, this value is higher, and moisturizing effect is more obvious.
In formula: T0For sample sets initial value；
Tn is each time point data collection value of sample sets.
Moisture content of skin MMV Data-Statistics result before and after 6 sample use of table
As can be seen from Table 6, in test period 4h, after sample of the subject using addition extracted form natural plant ingredient,
The aqueous MMV value of skin is in raising trend, and since 1h, and before sample is not used relatively in test section, MMV value has conspicuousness
Difference (p < 0.05).
Hydration rate test result is shown in Fig. 1.As seen from Figure 1, it in test period 4h, after subject uses sample, surveys
The hydration rate for trying area is positive value since 1h, illustrates that sample has the effect of supplement moisture of skin；The wherein hydration of 2# sample
Rate is always above 1#.
2, skin barrier effect is repaired --- moisture of skin, which scatters and disappears, to be changed
Moisture of skin windage (Transepidermal water loss, TEWL) reflects in test period, test block
Domain moisture loss changes with time rule, it can be worth smaller, moisture with the reparation skin barrier function of characterization test sample
It scatters and disappears fewer, it is stronger to repair skin barrier ability.
Test sample: 1# control group is bare substrate (matrix formulations are shown in Table 3, and do not contain plant extracts)；2# experiment
Group is cream prepared by embodiment 4.
Moisture of skin, which scatters and disappears, changes the same hydration rate of test method.
Percentage of water loss (%)=(sample sets water loss amount-starting moisture windage)/starting moisture windage × 100.
Percentage of water loss=(Tn-T0)/T0, this value is lower, and water lock effect is more obvious.
In formula: T0 is sample sets initial value；
Tn is each time point data collection value of sample sets；
Skin water loss amount TEWL Data-Statistics result before and after 7 sample use of table
By table 7 to find out, in test period 4h, after subject uses sample, skin fluid loss TEWL value becomes in reduction
Gesture, and since 1h, before sample is not used relatively in test section, there is significant difference (p < 0.05) in TEWL value.
Percentage of water loss test result is shown in Fig. 2.As seen from Figure 2, it in test period 4h, after subject uses sample, surveys
Try area percentage of water loss when 1h always be negative value, illustrate sample have reduce skin water loss effect；Wherein when 1h
The effect of 2# sample is better than 1#, and the effect of 2# sample is better than 1# when 4h.
By test result as can be seen that being added to skin moisture content after natural plant extracts of the invention in matrix
Value increases, water lock significant effect, illustrates that plant extracts of the invention has good moisturizing and repairs skin barrier and makees
With.
Two, improve skin roughness
1. normal individual trial is tested
Laboratory sample is that embodiment 4 prepares skin care cream, and human face on probation has different degrees of pachylosis phenomenon.
Above-mentioned cream is subjected to human facial skin and smears test, the time is one month, 40 people of number on probation, the age 50 weeks
Year old or more, every group of 20 people are randomly divided into 2 groups, and respectively (blank cream matrix, matrix formulations are shown in Table for experimental group, blank control group
3, and do not contain plant extracts).
Blank cream matrix used the preparation method is as follows:
(1) B phase: butanediol, glycerol, carbomer and xanthan gum are mixed, stirred evenly, for use；Other raw materials of B phase add
Enter in water, be stirring evenly and then adding into the mixture of butanediol, glycerol, carbomer and xanthan gum, be heated to 80 DEG C, mixes；
(2) A phase: A phase raw material is heated to 80 DEG C, mixes；
(3) the A phase of step (2) is all added in the B phase of step (1), 2000r/min, homogeneous 7min；Propylene is added
Amide/ammonium acrylate copolymer/polyisobutene/polysorbate -20 (C phase), 2000r/min, homogeneous 3min；40r/min is stirred
After mixing 10min, start stirring cooling, stirring rate 30r/min, rate of temperature fall is 1~2 DEG C/min；
(4) when temperature drops to 45 DEG C, preservative is added, stirs evenly, continues to be cooled to 40 DEG C hereinafter, to obtain the final product.
It is fed back according to user, is reduced using the roughness of skin after product and skin moisturizing degree improves, result on trial is such as
Table 8:
The cream of the present invention of table 8 improves pachylosis recruitment evaluation table
Investigation result confirms that the embodiment of the present invention 4 prepares cream and can effectively keep moistening for skin without greasy feeling, makes
With soft and moist later comfortable, sufficiently keep the skin wet, can effectively reduce skin roughness.Inventor prepares cream using embodiment 5,6
Preparation repeats above-mentioned experiment, and effect is the same as above-mentioned.
Three, improve the colour of skin
Skin brightness is promoted, then the improvement colour of skin effect of skin care item is preferable.Skin brightness variation was reflected in test period,
Experimental Area L value changes with time rule.
Skin brightness difference (Δ T)=each time point L value (Tn)-after product is used to use L value (T before product0)
The change rate of skin brightness=(sample sets L value-sample sets L value initial value)/sample sets L value initial value
Experimental method: 4 gained cream of embodiment tries out 40 people of number as experimental group sample, and the age 50 is more than one full year of life, often
20 people of group, are randomly divided into 2 groups, respectively experimental group, blank group, are analyzed using skin brightness tester tested before and after smearing sample
Person's skin brightness changes over time relationship.
Smearing mode: the full face of experimental group smears 4 gained cream of embodiment, 2 times a day, once in the morning and once at night, for 4 weeks, real
Other skin care item are stopped using during testing.Blank group does not smear skin care item.
Experimental result is as shown in figure 3, the results show that 4 gained cream of embodiment has the effect of good bright color.It is real
Example 5, the above test of 6 gained preparation of embodiment repetition are applied, conclusion is same as above.
Four, improve skin metabolism ----promote skin microcirculation efficacy assessments
Experimental method: for 4 gained cream of embodiment as experimental group sample, subject is the China of 55 one full year of life of skin health
Women detects facial blood flow velocity and temperature before and after smearing sample using skin infrared thermal imager.
Smearing mode: full face is smeared.
Skin infrared thermal imaging: the infrared thermal imaging figure of skin can detecte facial blood flow speed and temperature, can be anti-
Facial QI-blood circulation situation is reflected, blood flow velocity is fast, temperature is high, then skin metabolism is good.Experimental result is as shown in Figure 4.Skin
Skin infrared thermal imaging the results show that trier using after sample 4 weeks (shown in Fig. 4 right figure), compared to using (Fig. 4 before sample
Shown in left figure) blood flow velocity of skin promotes.
Infrared thermal imaging is new old for improving face it is experimentally confirmed that 4 gained cream of embodiment has good nourishing effect
Metabolism has good effect.To embodiment 1, embodiment 2, the preparation gained plant extracts of embodiment 3,5,6 gained of embodiment
Cream is subjected to the same test, and is as a result same as above.
Claims (13)
1. a kind of external natural plant composition for keeping senile skin health moist, it is characterised in that by following parts by weight
Each raw material composition: 10~50 parts by weight of dendrobium nobile, 10~30 parts by weight of armeniaca mume, 10~20 parts by weight of rosemary, chamomile 5~
1~30 parts by weight of 30 parts by weight, 1~20 parts by weight of paniculate swallowwort and waltheria indica.
2. external natural plant composition as described in claim 1, it is characterised in that be made of each raw material of following parts by weight:
35 parts by weight of dendrobium nobile, 10 parts by weight of armeniaca mume, 15 parts by weight of rosemary, 30 parts by weight of chamomile, 14 parts by weight of paniculate swallowwort and
1 parts by weight of waltheria indica.
3. a kind of external natural plant extracts for keeping senile skin health moist, it is characterised in that by claim 1
Or plant composition described in 2 is prepared by the following method to obtain:
(1) after each raw material crushes, parts by weight according to claim 1 or 2 weigh each raw material, mix；
(2) mass ratio of extracting in water, raw material and water is 10~30:150~350, and 60 DEG C~100 DEG C are extracted 1~4 hour；
(3) extracting solution that step (2) obtains is cooled to 20~30 DEG C, the filtering of 100~200 mesh carries out vacuum after filtering out residue
Filter, collect filtrate to get.
4. exterior-applied plant extract as claimed in claim 3, it is characterised in that the mass ratio of raw material and water is 15 in step (2)
~25:180~200.
5. external natural plant extracts as claimed in claim 3, it is characterised in that vacuum filtration packet described in step (3)
It includes and spreads two layers of filter paper in Buchner funnel, the diatomite of folder 0.3~0.6cm thickness, is then filtered by vacuum among filter paper.
6. the described in any item external natural plant extracts of claim 3-5 are preparing the purposes in external-use skin care preparation.
7. purposes as claimed in claim 6, it is characterised in that the external-use skin care preparation has moisturizing, improves skin
Roughness improves the effect of colour of skin and improvement skin microcirculation.
8. a kind of external-use skin care preparation for keeping senile skin health moist, it is characterised in that the skin care formulation is by right
It is required that the described in any item external natural plant extracts of 3-5 and skin care field customary adjuvant are made.
9. a kind of cream for keeping senile skin health moist, it is characterised in that by A phase, B phase, C phase and D phase composition；
Wherein, the A phase includes PEG-100 stearine/stearine, dimethyl silicone polymer, Ji Wusi
Alcohol distearate, isononyl isononanoate, jojoba oil, isopropyl myristate, cetostearyl alcohol, Queensland nut seed oil, hydrogen
Change polyisobutene, VE acetate and caprylic/capric triglyceride；
Wherein, the B phase include carbomer, glycerol, xanthan gum, butanediol, oat beta glucan, EDETATE SODIUM, glycine betaine with
And water；
Wherein, the C phase includes acrylamide/ammonium acrylate copolymer/polyisobutene/polysorbate -20；
Wherein, the D phase includes the described in any item external natural plant extracts of claim 3-5 and preservative；
Wherein the mass percentage of each raw material is as follows:
10. cream as claimed in claim 9, it is characterised in that the mass percentage of each raw material is as follows:
11. the cream as described in claim 9 or 10, it is characterised in that be prepared in accordance with the following methods:
(1) B phase: butanediol, glycerol, carbomer and xanthan gum are mixed, stirred evenly, for use；Water is added in other raw materials of B phase
In, it is stirring evenly and then adding into the mixture of butanediol, glycerol, carbomer and xanthan gum, is heated to 80~85 DEG C, is mixed；
(2) A phase: A phase raw material is separately heated to 80~85 DEG C, mixes；
(3) the A phase that step (2) obtains all is added in the B phase that step (1) obtains, 2000~3000r/min, homogeneous
5min~10min；Acrylamide/ammonium acrylate copolymer/polyisobutene/polysorbate -20,2000~3000r/ is added
Min, 1~3min of homogeneous；30~50r/min after stirring 5~10min, starts stirring and cools down, 30~50r/min of stirring rate,
Rate of temperature fall is 1~2 DEG C/min；
(4) when temperature drops to 45~50 DEG C, preservative is added and the described in any item external natural plants of claim 3-5 mention
It takes object, stirs evenly, continue to be cooled to 40 DEG C hereinafter, to obtain the final product.
12. cream described in claim 9 or 10 is in skin moisture-keeping, improvement skin roughness, the improvement colour of skin and improves skin
Purposes in microcirculation.
13. purposes as claimed in claim 12, it is characterised in that the target user of the cream is the elderly.
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| CN108888573B (en) * | 2018-08-06 | 2021-11-19 | 吉安智企企业服务有限公司 | Soothing and moisturizing cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005112793A (en) * | 2003-10-08 | 2005-04-28 | Norihide Yamaguchi | Bleaching cosmetic |
| CN104983642A (en) * | 2015-07-23 | 2015-10-21 | 北京工商大学 | Skincare external traditional Chinese medicine composition, skincare preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005112793A (en) * | 2003-10-08 | 2005-04-28 | Norihide Yamaguchi | Bleaching cosmetic |
| CN104983642A (en) * | 2015-07-23 | 2015-10-21 | 北京工商大学 | Skincare external traditional Chinese medicine composition, skincare preparation and preparation method thereof |
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