CN108815080A - A kind of preparation method of the plant extracts for the black eye that has effects that dispel - Google Patents
A kind of preparation method of the plant extracts for the black eye that has effects that dispel Download PDFInfo
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- CN108815080A CN108815080A CN201810954328.5A CN201810954328A CN108815080A CN 108815080 A CN108815080 A CN 108815080A CN 201810954328 A CN201810954328 A CN 201810954328A CN 108815080 A CN108815080 A CN 108815080A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The present invention relates to a kind of preparation methods of the plant extracts of black eye that has effects that dispel, it is characterised in that：Using following steps：A, the fresh sophora bud and semen coicis are chosen respectively, clean, is dry, crushing, sieving, in mass ratio 3:1 weighs sophora bud powder and Coix Seed as plant mixture；B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine respectively, and magnetic agitation is uniform in 30~50 DEG C of thermostat water baths, is cooled to room temperature as eutectic solvent；C, in mass ratio 1:2 ~ 6 weigh plant mixture and step eutectic solvent, are uniformly mixed, are heated to 40 ~ 60 DEG C, and supersonic oscillations extract 1 ~ 3h, filter to have effects that the plant extracts of black eye of dispelling.Containing a variety of high-content active constituents such as rutin, isoquercitin, daphnin and semen coicis rouge, black eye of dispelling significant effect in the plant extracts of the black eye prepared by the present invention that has effects that dispel, and the advantages that this method recovery rate is higher.
Description
Technical field
The present invention relates to technical field of plant extraction, in particular to a kind of plant extracts for the black eye that has effects that dispel
Preparation method.
Background technique
In recent years, as climate change, environmental pollution and rhythm of life are accelerated, black eye is asked as a kind of eye part skin
The incidence of topic dramatically increases, and leverages the daily life of consumer.Black-eyed treatment method is divided into high concentration of hydrogen
Quinone is the chemotherapy of representative and using laser therapy as the physical therapy of representative, but there are therapeutic process pain, convalescence are long etc.
Disadvantage.Therefore, how safely, effectively, without adverse affects alleviate black eye symptom, the problem of becoming people's growing interest.
The Multiple components such as flavonoids, glycoside in natural traditional Chinese medicine plant have anti-inflammatory, whitening and reduce blood clotting
Effect, for inhibiting black-eyed generation to have potential application.Extracted form natural plant method is many kinds of, most common
It is simple and convenient to solvent extraction method, but the timesharing of various plants group is extracted using water, ethyl alcohol equal solvent, because solvent polarity is more single
One, cause extract product it is more single, can not the active matter to the opposed polarity of various plants component effectively extracted, gained
The recovery rate of active constituent is relatively low.
Eutectic solvent refers to by the hydrogen bond receptor of certain stoichiometric ratio（Such as quaternary ammonium compound）And hydrogen-bond donor
（Such as amide, carboxylic acid and polyalcohol compound）Two components being composed or three component eutectic mixtures, freezing point are aobvious
The fusing point for being lower than each component pure material is write, physicochemical properties are closely similar with ionic liquid, therefore also someone returns it
For a kind of novel ion liquid or ionic liquid analog.The advantages of eutectic solvent extracts, is that can disposably extract plant
Water-soluble active ingredient in object, such as plant polyose, organic acid can also extract oil-soluble flavonoids, saponins, advanced rouge
Fat acids, moreover it is possible to extract the water-soluble and bad tannins of oil-soluble.Ultrasonic extraction refers to that ultrasonic wave passes through cavitation effect, machine
Cell wall, the cell membrane of the broken plant cell such as tool effect, fuel factor, so that more cellular contents be made to be dissolved into solvent
Extracting mode, have many advantages, such as that extraction time is short, save that solvent, recovery rate are high, are widely used, obtained in field of plant extraction
It must be widely applied.
Summary of the invention
The technical problem to be solved by the present invention is to provide a kind of preparation side of the plant extracts of black eye that has effects that dispel
Method, in plant extracts prepared by this method containing the various actives such as rutin, isoquercitin, daphnin and semen coicis rouge at
Point, black eye of dispelling significant effect, and this method, relative to existing common plant extracting method, the active matter recovery rate in plant is more
It is high.
In order to solve the above technical problems, the present invention uses following technical scheme：A kind of plant for the black eye that has effects that dispel
The preparation method of extract, it is characterised in that：Using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and it is sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 6 ~
Then 8h is crushed with pulverizer respectively, cross 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs Chinese scholartree
Rice flour end and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine respectively, is added in round-bottomed flask, in 30~50 DEG C of perseverances
30~60min of magnetic agitation in warm water bath, control revolving speed are 500 ~ 800 turns/min, then cool to room temperature, obtain colourless
Prescribed liquid, as eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, add them into
In rustless steel container be uniformly mixed, be heated to 40 ~ 60 DEG C, under 100 ~ 300W power condition using ultrasonic oscillator extract 1 ~
Then 3h filters gained liquid by the stainless steel filter that aperture is 1 micron, the plant for obtaining the black eye that has effects that dispel mentions
Take object.
In the plant extracts of the black eye that has effects that dispel of the method for the present invention preparation, the mass content of rutin 14.00 ~
14.30%, the mass content of isoquercitin 6.10 ~ 6.50%, the mass content of daphnin 0.60 ~ 0.80%, coixenolide
Mass content is 4.10 ~ 4.50%.
The semen coicis is purchased from Xingyi of Guizhou, is the mature seed kernel of gramineae.
The sophora bud is purchased from prepared slices of Chinese crude drugs factory of Nanjing Hai Yuan Yao Shi Services Co., Ltd, is the bud of leguminous plant Chinese scholartree.
The pulverizer is 30B type high speed Universal pulverizer, and manufacturer is Changzhou Bang Ni drying equipment Co., Ltd.
The vacuum oven is DZF-1 type vertical vacuum drying box, and manufacturer is Beijing Lin Mao scientific & technical corporation.
The glycerol（INCI Name：GLYCERIN, CAS No.：56-81-5）, isoprene（INCI Name：
ISOPENTYLDIOL, CAS No.：2568-33-4）, glycine betaine（INCI Name：BETAINE, CAS No.：107-43-7）?
Purchased from traditional Chinese medicines chemical reagent Co., Ltd, rank is that analysis is pure.
The ultrasonic oscillator model BG-20C is purchased from Guangzhou Bang Jie Environmental Protection Technology Co., Ltd.
The glycerol, isoprene, glycine betaine of extra fine quality ratio are fabricated to eutectic solvent by the present invention, as Extraction solvent
Assisting ultrasonic method compared to traditional water extraction or single solvent extraction method, can extract in the sophora bud and semen coicis simultaneously
Rutin, isoquercitin, daphnin and semen coicis rouge isoreactivity object, and the feature that extract obtained active component content is high.
The recovery rate of Active principals of the invention is 31.45 ~ 32.50%.
Have effects that dispel prepared by the present invention plant extracts of black eye, can be used as cosmetic functional additive,
It is added in black eye class skin care item of dispelling, use can also be smeared directly to have black-eyed effect of significantly dispelling.
To confirm that the present invention has These characteristics, the present invention has carried out following experiment.
Test the measurement of active component content in the plant extracts for the black eye that has effects that dispel prepared by the one, present invention
With the calculating of recovery rate
With the content of rutin and daphnin in ultraviolet specrophotometer measurement plant extracts, high performance liquid chromatography is used（HPLC）Method
Measure the content of isoquercitin and coixenolide in plant extracts.Concrete content is shown in Table 1.
Rutin in each embodiment plant extracts of table 1, isoquercitin, daphnin and semen coicis rouge content
Recovery rate=Active principals quality/raw material quality ... ... ... formula 1
The quality of Active principals is the sum of rutin in extract, isoquercitin, daphnin and semen coicis lipid amount.
The mass content of rutin is 14.00 ~ 14.30% in the plant extracts prepared by the present invention after measured, isoquercitin
Mass content 6.10 ~ 6.50%, the mass content of daphnin 0.60 ~ 0.80%, the mass content of coixenolide 4.10 ~
4.50%.Calculated by formula 1, the Active principals recovery rate of embodiment 1-5 is respectively 31.95%, 31.94%, 31.88%,
31.80% and 31.79%.As it can be seen that preparation method of the invention can extract simultaneously rutin in the sophora bud and semen coicis, isoquercitin,
Daphnin and semen coicis rouge isoreactivity object, and the content of extract obtained middle active constituent is high.
Experiment two, the comparative experiments of preparation method of the present invention and other preparation methods
Control group 1 ~ 4 is set up, control group 1 is using water as Extraction solvent, and control group 2 is using ethyl alcohol as Extraction solvent, control
Group 3 use ethanol water that mass fraction is 50% as Extraction solvent, the use ethyl acetate of control group 4 as Extraction solvent,
Other extraction steps and extraction conditions are same as Example 1, active ingredient Rutin, different Mongolian oak in plant extracts obtained by each control group
The content of Pi Su, daphnin and semen coicis rouge are shown in Table 2.
Rutin, isoquercitin, daphnin and semen coicis rouge in 1 ~ 4 gained plant extracts of 2 embodiment 1 of table and control group
Content
As can be seen from Table 2, active component content is lower in 1 ~ 4 gained plant extracts of control group, and do not occur daphnin.It is logical
The calculating of formula 1 is crossed, 1 ~ 4 Active principals recovery rate of control group is respectively 10.93%, 12.32%, 12.55% and 10.53%, remote low
The Active principals recovery rate 31.95% in embodiment 1.To sum up, the present invention and traditional water extraction or single solvent extraction
The method advantage high compared to active object recovery rate.
Black eye effect measurement experiment of dispelling of plant extracts prepared by experiment three, the present invention
Dermal melanin content（MI value）：MI value characterizes melanin index, and numberical range is 0~999, measures the higher explanation of numerical value
Melanin content is higher in skin.The measuring principle of Mexameter MX18 dermal melanin and ferroheme test probe is to be based on
The principle of spectral absorption（RGB）, by measuring the illumination of specific wavelength, volume reflection is black in skin to determine on human skin
The content of pigment.
30 people of subject is chosen, the age 20~39 years old, be office work person.Subject's exclusion condition meets GB
171492-1997《Cosmetics contact dermatitis diagnostic criteria and treatment principle》, subject without serious systemic disease, without exempting from
Epidemic disease defect or autoimmune disease；No active anaphylactia；To skin-care cosmetics without allergies；In 1 month not
Whole body uses hormone medicine and immunosuppressor；Non-pregnant or nursing period；No ethics taboo.
20 ± 2 DEG C of environment temperature, relative humidity 52%-58% of control test, after tester's face cleans, in this environment
Under sit quietly and tested after 30min, use plant extracts sample with dermal melanin and ferroheme test probe detection subject
The MI value of the preceding periocular area of product.According to subject using the MI value situation tested before sample, subject is divided into control group and reality
Group is tested, guarantees the initial value no significant difference of control group and experimental group subject.
Subject is after daily face cleaning, and the plant extracts that experimental group prepares embodiment 1 is with 1.25 μ L/cm2Density is equal
It is even to be coated on eye circumference test position, each 1 time of morning and evening daily, and any product is not used after control group face cleaning.It is mentioned using plant
1,2 and 4 week after taking object, sat quietly 30min under conditions of 20 ± 2 DEG C of temperature, relative humidity 52%-58%, after blood flow is stablized
The MI value of control group and experimental group subject is detected, everyone continuous measurement 3 times every time are averaged.
The test result of skin MI value is shown in Table 3（± s be control group and all subject MI values of experimental group average ±
Standard deviation）.As shown in Table 3, in 4 weeks of test, after the plant extracts that subject is prepared using embodiment one, MI value is in drop
Low tendency, and at the 1st, 2 and 4 week, it is below control group.Statistical result shows, at the 2nd and 4 week, experimental group is not relative to
Before smearing sample, there are significant differences for MI value（P < 0.05）, experimental group is relative to control group, and there are significant differences for MI value
（P < 0.05）, illustrate that the plant extracts can reduce the melanin content in periocualr skin, it is black-eyed with significantly dispelling
Effect.
The situation of change of 3 skin MI value of table（±s）
In conclusion the plant extracts of the black eye prepared by the present invention that has effects that dispel, contains rutin, isoquercitin, winter daphne
The a variety of active ingredients such as glycosides and semen coicis rouge, black eye of dispelling excellent effect, and the advantages that this method active matter recovery rate is high.
Specific embodiment
The present invention will be further described combined with specific embodiments below, but the invention is not limited to following embodiments.
Embodiment 1：A kind of preparation method of the plant extracts for the black eye that has effects that dispel, using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and be sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 6h,
Then it is crushed respectively with pulverizer, crosses 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs the sophora bud
Powder and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine in a round bottom flask respectively, in thermostat water bath, protects
30 DEG C of temperature, magnetic agitation 30min are held, control revolving speed is 500 turns/min, to take out after reaction, after being cooled to room temperature
To colourless transparent liquid, i.e. eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, by them stainless
40 DEG C are heated in steel container after mixing, 2h is extracted using ultrasonic oscillator under the power condition of 300W, will be extracted
The stainless steel filter that gained liquid passage aperture is 1 micron filters, and gained filtrate is to have effects that dispel the plant of black eye
Extract.
Gained have effects that dispel black eye plant extracts in active ingredient Rutin, isoquercitin, daphnin and coix lacryma-jobi
The mass content of benevolence ester is respectively 14.13%, 6.48%, 0.74% and 4.21%, and Active principals recovery rate is 31.95%.
Embodiment 2：A kind of preparation method of the plant extracts for the black eye that has effects that dispel, using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and be sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 8h,
Then it is crushed respectively with pulverizer, crosses 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs the sophora bud
Powder and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine in a round bottom flask respectively, in thermostat water bath, protects
Temperature 50 C is held, magnetic agitation 45min, control revolving speed is 600 turns/min, to take out after reaction, after being cooled to room temperature
To colourless transparent liquid, i.e. eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, by them stainless
50 DEG C are heated in steel container after mixing, 3h is extracted using ultrasonic oscillator under the power condition of 100W, will be extracted
The stainless steel filter that gained liquid passage aperture is 1 micron filters, and gained filtrate is to have effects that dispel the plant of black eye
Extract.
Gained have effects that dispel black eye plant extracts in active ingredient Rutin, isoquercitin, daphnin and coix lacryma-jobi
The mass content of benevolence ester is respectively 14.08%, 6.37%, 0.78% and 4.32%, and Active principals recovery rate is 31.94%.
Embodiment 3：A kind of preparation method of the plant extracts for the black eye that has effects that dispel, using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and be sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 7h,
Then it is crushed respectively with pulverizer, crosses 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs the sophora bud
Powder and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine in a round bottom flask respectively, in thermostat water bath, protects
40 DEG C of temperature, magnetic agitation 60min are held, control revolving speed is 700 turns/min, to take out after reaction, after being cooled to room temperature
To colourless transparent liquid, i.e. eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, by them stainless
60 DEG C are heated in steel container after mixing, 1h is extracted using ultrasonic oscillator under the power condition of 300W, will be extracted
The stainless steel filter that gained liquid passage aperture is 1 micron filters, and gained filtrate is to have effects that dispel the plant of black eye
Extract.
Gained have effects that dispel black eye plant extracts in active ingredient Rutin, isoquercitin, daphnin and coix lacryma-jobi
The mass content of benevolence ester is respectively 14.15%, 6.20%, 0.68% and 4.47%, and Active principals recovery rate is 31.88%.
Embodiment 4：A kind of preparation method of the plant extracts for the black eye that has effects that dispel, using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and be sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 8h,
Then it is crushed respectively with pulverizer, crosses 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs the sophora bud
Powder and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine in a round bottom flask respectively, in thermostat water bath, protects
Temperature 50 C is held, magnetic agitation 30min, control revolving speed is 800 turns/min, to take out after reaction, after being cooled to room temperature
To colourless transparent liquid, i.e. eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, by them stainless
60 DEG C are heated in steel container after mixing, 3h is extracted using ultrasonic oscillator under the power condition of 300W, will be extracted
The stainless steel filter that gained liquid passage aperture is 1 micron filters, and gained filtrate is to have effects that dispel the plant of black eye
Extract.
Gained have effects that dispel black eye plant extracts in active ingredient Rutin, isoquercitin, daphnin and coix lacryma-jobi
The mass content of benevolence ester is respectively 14.11%, 6.25%, 0.70% and 4.38%, and Active principals recovery rate is 31.80%.
Embodiment 5：A kind of preparation method of the plant extracts for the black eye that has effects that dispel, using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and be sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 6h,
Then it is crushed respectively with pulverizer, crosses 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs the sophora bud
Powder and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine in a round bottom flask respectively, in thermostat water bath, protects
40 DEG C of temperature, magnetic agitation 60min are held, control revolving speed is 600 turns/min, to take out after reaction, after being cooled to room temperature
To colourless transparent liquid, i.e. eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, by them stainless
50 DEG C are heated in steel container after mixing, 2h is extracted using ultrasonic oscillator under the power condition of 300W, will be extracted
The stainless steel filter that gained liquid passage aperture is 1 micron filters, and gained filtrate is to have effects that dispel the plant of black eye
Extract.
Gained have effects that dispel black eye plant extracts in active ingredient Rutin, isoquercitin, daphnin and coix lacryma-jobi
The mass content of benevolence ester is respectively 14.16%, 6.28%, 0.75% and 4.24%, and Active principals recovery rate is 31.79%.
Claims (1)
1. a kind of preparation method of the plant extracts for the black eye that has effects that dispel, it is characterised in that：Using following steps：
A, the fresh sophora bud and semen coicis are chosen respectively, clean and it is sufficiently mixed in the vacuum oven for be placed on 50 DEG C dry 6 ~
Then 8h is crushed with pulverizer respectively, cross 60 meshes, obtain sophora bud powder and Coix Seed, in mass ratio 3:1 weighs Chinese scholartree
Rice flour end and Coix Seed, as plant mixture；
B, in mass ratio 4:3:1 weighs glycerol, isoprene, glycine betaine respectively, is added in round-bottomed flask, in 30~50 DEG C of perseverances
30~60min of magnetic agitation in warm water bath, control revolving speed are 500 ~ 800 turns/min, then cool to room temperature, obtain colourless
Prescribed liquid, as eutectic solvent；
C, in mass ratio 1:2 ~ 6 weigh eutectic solvent obtained by plant mixture obtained by step A and step B, add them into
In rustless steel container be uniformly mixed, be heated to 40 ~ 60 DEG C, under 100 ~ 300W power condition using ultrasonic oscillator extract 1 ~
Then 3h filters gained liquid by the stainless steel filter that aperture is 1 micron, the plant for obtaining the black eye that has effects that dispel mentions
Take object.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109985418A (en) * | 2019-04-22 | 2019-07-09 | 南京师范大学常州创新发展研究院 | A kind of extracting method and application of active material extracting solution |
| CN113440460A (en) * | 2021-06-18 | 2021-09-28 | 上海应用技术大学 | Method for extracting double-component auxiliary agent of coix seed active substance |
| CN113713426A (en) * | 2021-09-14 | 2021-11-30 | 云南茗杨天下绿色食品有限公司 | Method for efficiently extracting effective components of plants |
| CN114307235A (en) * | 2021-12-10 | 2022-04-12 | 江苏鸿祺生物科技有限公司 | Propolis with high flavone content and supercritical extraction process thereof |
| CN114983881A (en) * | 2022-08-03 | 2022-09-02 | 深圳市萱嘉生物科技有限公司 | Extraction method of sargassum salmonii extract, sargassum salmonii extract and application thereof |
| CN115212151A (en) * | 2022-08-03 | 2022-10-21 | 深圳市萱嘉生物科技有限公司 | Extraction method of gentian extract, gentian extract and application of gentian extract |
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| CN109985418A (en) * | 2019-04-22 | 2019-07-09 | 南京师范大学常州创新发展研究院 | A kind of extracting method and application of active material extracting solution |
| WO2020215756A1 (en) * | 2019-04-22 | 2020-10-29 | 南京师范大学常州创新发展研究院 | Method for extracting active substance extraction solution and application |
| CN113440460A (en) * | 2021-06-18 | 2021-09-28 | 上海应用技术大学 | Method for extracting double-component auxiliary agent of coix seed active substance |
| CN113713426A (en) * | 2021-09-14 | 2021-11-30 | 云南茗杨天下绿色食品有限公司 | Method for efficiently extracting effective components of plants |
| CN114307235A (en) * | 2021-12-10 | 2022-04-12 | 江苏鸿祺生物科技有限公司 | Propolis with high flavone content and supercritical extraction process thereof |
| CN114983881A (en) * | 2022-08-03 | 2022-09-02 | 深圳市萱嘉生物科技有限公司 | Extraction method of sargassum salmonii extract, sargassum salmonii extract and application thereof |
| CN115212151A (en) * | 2022-08-03 | 2022-10-21 | 深圳市萱嘉生物科技有限公司 | Extraction method of gentian extract, gentian extract and application of gentian extract |
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