CN108057051A - Composition comprising Herba Saussureae Involueratae and birds nest extract and its preparation method and application - Google Patents
Composition comprising Herba Saussureae Involueratae and birds nest extract and its preparation method and application Download PDFInfo
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- CN108057051A CN108057051A CN201610980454.9A CN201610980454A CN108057051A CN 108057051 A CN108057051 A CN 108057051A CN 201610980454 A CN201610980454 A CN 201610980454A CN 108057051 A CN108057051 A CN 108057051A
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- Prior art keywords
- extract
- nest
- herba saussureae
- saussureae involueratae
- bird
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Medical Informatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of composition, its relevant purposes and products and preparation method comprising Herba Saussureae Involueratae extract and birds nest extract.The present invention can give full play to the effect of Herba Saussureae Involueratae and bird's nest, have the oxidation resistance significantly increased and whitening effect.The preparation process of the present invention is simple, and can economization cost, can more protect the natural precious resources of wild Herba Saussureae Involueratae increasingly in short supply.
Description
Technical field
The present invention relates to for disease treatment, health care or product cosmetically, in particular to Herba Saussureae Involueratae and bird's nest
Application of the extract in terms of said products.
Background technology
Herba Saussureae Involueratae also known as lanatechead saussurea herb with flower (scientific name：Saussurea involucrata (Kar.et Kir.) Sch.-Bip.),
Lotus flower is similar to because it is pushed up, therefore lanatechead saussurea herb with flower of gaining the name, abbreviation saussurea involucrata.It is 15-35 centimetres high for perennial herb.Root-like stock is thick, neck quilt
The leaf vestiges of most brown.Stem is sturdy, hairless.Leaf is intensive, basal leaf and stem leaf stockless, and blade ellipse or ovate are oval
Shape；Topmost leaf bract shape, film quality is faint yellow, surrounds total inflorescence, and there is pointed tooth at edge.Capitulum 10-20, it is close on stem top
Integrate spherical total inflorescence.Involucre hemispherical, 1 centimetre of diameter；3-4 layers of phyllary, edge or whole puces.Little Hua purples.
Achene oval.The dirty white of pappus.The flowering fruit bearing stage 7-9 months.It is distributed in China's more ground severe cold areas, Russia and Kazakhstan
It is distributed.It is born in the rock seam near high mountain snow line, cliff and ice sulphur ruckle, 2400-4000 meters of height above sea level.It is produced most with Tianshan Mountains
More, matter is also optimal.It can make medicinal, also there is certain ornamental value.Herba Saussureae Involueratae is classified as second class protection and planted by China in 1996
Object, Herba Saussureae Involueratae are uniquely to be included in《Chinese Plants Red Data Book》Saussurea involucrata plant, be China national three-level endangered species.2000
No. 13 files of State Council have prohibited the wild saussurea involucrata of excavation.Wild saussurea involucrata leans on seed growing, and growth period needs 6 to 8 years, if even
It eradicates, saussurea involucrata just can not possibly grow in situ again.Five sixties of last century, generally the gravel matter in 1800 meters or so of height above sea level
Slope can adopt saussurea involucrata.Xinjiang, China saussurea involucrata area is about 50,000,000 mu that kind, but now less than 1000
Ten thousand mu.The annual 7-8 months are the Xinjiang Tianshan wild saussurea involucrata times floriferous, however this every when, and 3000 meters or more are avenged
Line nearby can all have large quantities of criminals to come mad excavation.Local relevant expert represents again and again, if this phenomenon obtains not
To containment, have more than is needed several years, the species of this preciousness of saussurea involucrata may disappear from the earth.
Lanatechead saussurea herb with flower contains protein, amino acid, flavone compound, alkaloid etc..With clearing and activating the channels and collaterals, dispelling cold and removing dampness,
Hemostasia and detumescence, isostere endotoxin and other effects.Lanatechead saussurea herb with flower is warm-natured, sweet-bitter flavor, enters liver,spleen,kidney three and passes through, tool except cold, establishing-Yang, menstruation regulating,
The work(of hemostasis, for treating under impotence, waist and knee weakness, menoxenia, uterine bleeding band, rheumatic arthritis and traumatic hemorrhage etc.
Disease.What Qing Dynasty's Zhao Xuemin write《A Supplement to the Compendium of Materia Medica》Just have that " the ground accumulated snow in Great Cold, spring and summer do not dissipate, and have grass, class lotus between snow in one book
It is spend only stem, lovely between graceful snow " and " there is Tianshan Mountains on its ground, summer in winter accumulated snow, has lotus in snow, using Tianshan Mountains summit person as the first " note
It carries.Nature and flavor：Hardship, slight bitter, temperature；Major function：Clearing heat and detoxicating, wind-damp dispelling, detumescence, analgesic.《A Supplement to the Compendium of Materia Medica》Described in：
" lanatechead saussurea herb with flower is similar to lotus flower, and up to ruler is permitted, and production Yi Li etc., production Tianshan Mountains peak person is the first ".It has correctly narrated the shape of saussurea involucrata
Shape and the place of production.Saussurea involucrata is perennial catananche also known as lanatechead saussurea herb with flower, encrinite, is born in Xinjiang Tianshan, Altai Mountains, Kun Lun Mountain
In rock seam, cliff and ice sulphur ruckle near snow line, produced at most with Tianshan Mountains, matter is also optimal.In terms of beauty, skin can be accelerated
Metabolism, reduce wrinkle, skin made to keep gloss, plentiful.It slows down aging.And have to facial freckle, chloasma hepaticum etc. well
The effect of.In addition, natural snow lotus contains natural snow lotus Huang cave class reed, saussurea involucrata lactones, Saussurea Polysaccharide etc..Its SPF is up to
22DSE.Therefore, there can be infringement of the protection skin from ultraviolet light, improve cutaneous pigmentation, delaying human body caducity makes one normal
Preserve the youth.
Bird's nest is a variety of birds of Apodidae (Apodidae) aerodramus (Collocalia), the saliva or saliva secreted out of
Liquid is mixed and condensed in its down on overhanging cliff, and the nest built up.It is Indonesia, Malaysia, Vietnam main product
Deng, according to《Bencao Shiyi》It records：" bird's nest is sweet light flat, supports lung yin greatly, and preventing phlegm from forming and stopping coughing, is mended and energy is clear, to nurse one's health the panacea of consumptive disease,
All diseases due to the deficiency syndrome of the lung, and lower passerby cannot be eliminated, it can be all controlled with this ".The traditional Chinese medical science thinks that bird's nest nourishing yin to moisten dryness, QI invigorating are mended
In, governance wasting, expectoration asthma, spitting of blood, protracted dysentery, be suitable for having a delicate constitution, malnutritive, protracted dysentery chronic malaria, many coughs of phlegm, senile chronic
Bronchitis, bronchiectasis, pulmonary emphysema, pulmonary tuberculosis, spitting of blood, haematemesis and stomachache patients.Modern medicine finds that bird's nest can
Promote immune function, the effect of having delaying human body caducity, promote longevity.The effect of bird's nest is to improving skin is mostly derived from the traditional Chinese medical science
It is theoretical.The famous doctor Zhang Lu of the Qing Dynasty exists《This is through meeting source》Described in bird's nest " gold, water interpromoting relation in five elements can be made, grown in lung in kidney qi, and stomach Qi
Also pacified.In addition exist《The Yellow Emperor's Canon of Internal Medicine》Interior " lung governing skin and hair, department's breathing " on the books, it is seen that the effect of bird's nest is to improving skin master
To penetrate the function of improving lung.
Many diseases have proven to related with free radical in recent years.Therefore, many is treated using antioxidation mechanism
Disease is also taken seriously successively, including angiocardiopathy, chronic nephritis, senile dementia (Alzheimer ' s disease) and
Anaphylactia etc..Natural products with oxidation resistance is more widely used on the cosmetics of anti aging effect.
Melanin on human skin is that the dopachrome as caused by melanocyte (Melanocytes) is transformed
's.Melanin can be gradually ripe in the melanosome in melanocyte (Melanosome), it is ripe after melanosome just
Horn cell (Keratinocytes) can be transferred to along the dendron (Dentrite) of melanocyte, deepen the colour of skin.Inhibit
Tyrosinase activity can effectively reduce the generation of dopachrome and melanin, so that the colour of skin becomes lighter whiter.Current big portion
Part whitening drug such as hydroquinone (Hydroquinone) and ursin (Arbutin) etc. be for tyrosinase activity and
Realize white-skinned face function.It is disabled because of carcinogenic risk in 2006 although the white-skinned face function of hydroquinone is apparent.It
Afterwards, ursin is also because chemical constitution and hydroquinone are similar and disabled.The higher U.S. of security is just being looked for by current scientific circles
White product substitutes hydroquinone etc..
With beauty product made of natural plant extracts there are many currently on the market, however anti-oxidant or whitening effect
Fruit unobvious need complicated technique, high cost etc. to reach preferable anti-oxidant and whitening effect for cost.
In addition, there are different medication tradition and culture in different areas.As thousands of years of Chinese medicines develop, different regions
Gradually the medication of type into respective tool characteristic is traditional and cultural, wherein with traditional central plain area (north) and Lingnan area (south)
Dividing line it is the most apparent.For example, the growing environment of Herba Saussureae Involueratae and bird's nest greatly differs from each other.Herba Saussureae Involueratae is grown in the north of a desert outside the Pass, day
In the extremely cold environment on the mountain peak on mountain；And bird's nest is to be produced in the dark cave in the Shang Ge island of equator in dense jungle.From ancient times
So far in Chinese medicine preparation, such as north and south such as Herba Saussureae Involueratae and bird's nest, cross-border compatibility is all very rare.
The content of the invention
The present invention first is designed to provide a kind of composition, and it includes Herba Saussureae Involueratae extract and birds nest extracts.
In one aspect, the Herba Saussureae Involueratae extract can be Herba Saussureae Involueratae water or alcohol extracting thing.On the other hand,
The birds nest extract can be bird's nest water extract.
In one aspect, the weight ratio of the Herba Saussureae Involueratae extract and birds nest extract is about 5:1 to 1:2 scope,
Preferably from about 5:1 to 1:1, for example, about 5:1、4.5:1、4:1、3.5:1、3.4:1、3.3:1、3.2:1、3.1:1、3:1、2.9:1、
2.8:1、2.7:1、2.6:1、2.5:1、2:1、1.5:1、1:1、1:1.5 and 1:2.
In one aspect, the concentration of Herba Saussureae Involueratae extract is 0.001-0.1g crude drugs/ml, and for example, about 0.001-0.1g gives birth to
Medicine/ml, about 0.002-0.09g crude drugs/ml, about 0.003-0.08g crude drugs/ml, about 0.004-0.07g crude drugs/ml, about 0.005-
0.06g crude drugs/ml, about 0.006-0.05g crude drugs/ml, about 0.007-0.04g crude drugs/ml, about 0.008-0.03g crude drugs/ml,
About 0.009-0.02g crude drugs/ml or about 0.01g crude drugs/ml.
In one aspect, the concentration of birds nest extract is about 0.001-0.1g crude drugs/ml, and for example, about 0.001-0.1g gives birth to
Medicine/ml, about 0.002-0.09g crude drugs/ml, about 0.003-0.08g crude drugs/ml, about 0.004-0.07g crude drugs/ml, about 0.005-
0.06g crude drugs/ml, about 0.006-0.05g crude drugs/ml, about 0.007-0.04g crude drugs/ml, about 0.008-0.03g crude drugs/ml,
About 0.009-0.02g crude drugs/ml or about 0.01g crude drugs/ml.
In one aspect, Herba Saussureae Involueratae water extract can be made by the steps：Herba Saussureae Involueratae is provided；In water or water
Ultrasonic extraction is carried out in property medium；With remove residue, to obtain Herba Saussureae Involueratae water extract.In a specific embodiment,
Herba Saussureae Involueratae provides in powder form.
The usual mode of the art, such as filtering or centrifugation can be used, remove residue.
In one aspect, bird's nest water extract can be prepared by following steps：Bird's nest is soaked in water or aqueous medium；
Remove liquid；Water or aqueous medium stew it is soaking after bird's nest；It is carried with the bird's nest through stewing is removed with obtaining bird's nest water
Take object.
The usual mode of the art can be used, such as filter, remove liquid.
In one aspect, composition of the invention is not comprising carrying outside the Herba Saussureae Involueratae extract and birds nest extract
Take object or active ingredient.
The present invention second is designed to provide a kind of for anti-oxidant and/or whitening product, and it includes the present invention's
Composition.
The present invention the 3rd is designed to provide the composition of the present invention in preparing for anti-oxidant and/or whitening product
Purposes.
The present invention the 4th is designed to provide purposes of the composition of the present invention in anti-oxidant and/or whitening.
The present invention the 5th is designed to provide for the composition of anti-oxidant and/or whitening the present invention.
The present invention the 6th is designed to provide a kind of anti-oxidant and/or whitening method, including being applied to subject
The composition of the present invention.
The present invention the 7th is designed to provide a kind of method for the composition for preparing the present invention, including：A) this is provided
The Herba Saussureae Involueratae extract and birds nest extract of invention；And b) by the Herba Saussureae Involueratae extract and the birds nest extract with
About 5:1 to 1:2 weight ratio mixing.
Below in conjunction with the drawings and specific embodiments, the present invention will be described in detail, and thus those skilled in the art will be more clear
Chu legibly understands the above-mentioned purpose of the present invention.
Description of the drawings
Fig. 1 is to represent according to embodiments of the present invention 1 process flow diagram for preparing composition, wherein Herba Saussureae Involueratae extract
Weight proportion with birds nest extract is 3:1.
Fig. 2 is the standard curve of the absorbance under 570nm according to the Trolox of embodiment 2.
Fig. 3 represents according to embodiments of the present invention 3 birds nest extract, Herba Saussureae Involueratae extract and with different ratio
Birds nest extract and Herba Saussureae Involueratae extract composition oxidation resistance test result.
Fig. 4 represents according to embodiments of the present invention 4 birds nest extract and Herba Saussureae Involueratae extract with different ratio
Composition, Herba Saussureae Involueratae extract are to the result of the inhibitory action of tyrosinase activity.
Specific embodiment
The present invention is it has surprisingly been found that i.e., by Herba Saussureae Involueratae and bird's nest both north and south medicinal materials based on inventor
Compatibility generates unexpected synergistic effect in terms of anti-oxidant/anti-aging.The compatibility can not only significantly increase Tianshan Mountains snow
Anti-oxidant/anti-aging effects of lotus, while also enhance the whitening effect of the composition comprising the compatibility.
Herba Saussureae Involueratae extract
Herba Saussureae Involueratae (Saussurea involucrata (Kar.et Kir.) Sch.-Bip.) for the present invention can be with
It is used as medicine for complete stool, that is, takes saussurea involucrata herb.
The Herba Saussureae Involueratae extract of the present invention can be water extract or alcohol extracting thing, preferably water extract.This field skill
Art personnel can take the means of common techniques of this field to obtain the Herba Saussureae Involueratae extract of the present invention.For example, it is avenged for Tianshan Mountains
Lotus water extract, workable extracting method are not particularly limited, as long as it can fully extract what is contained in Herba Saussureae Involueratae
Water soluble ingredient.
Herba Saussureae Involueratae water extract can take various modes to obtain.For example, in the case where being heated or not heated, in water
Or Herba Saussureae Involueratae is added in water-bearing media, optionally it is soaked for a period of time.Herba Saussureae Involueratae can provide in the form of a powder, to promote
Into the extraction of water soluble ingredient.Preferably, can additionally apply ultrasonic wave, with shorten extraction time or without impregnate and/or heating
And individually carry out ultrasonic wave extraction.Extraction time can with for impregnate the water of Herba Saussureae Involueratae, whether application heating, whether apply
Other supplementary means (such as ultrasonic wave) etc. is added accordingly to adjust.Such as when heating and/or using ultrasonic wave, it can suitably reduce and carry
Take the time.On the contrary then corresponding extension.
Solid content is removed after extraction, to obtain Herba Saussureae Involueratae extracting solution.The removal of solid content can be used customary in the art
Such as centrifugation, filtering means.
Obtained Herba Saussureae Involueratae extracting solution can be converted into other forms through any known means in this field.It is such as chilled dry
It is dry to be converted into powder type, to be suitble to different special-purposes.
In a specific embodiment, Herba Saussureae Involueratae water extract is made by the steps：Herba Saussureae Involueratae powder is provided
End；Ultrasonic extraction is carried out in water or aqueous medium；With filter or be centrifuged off residue, to obtain Herba Saussureae Involueratae water extract.
More specifically, Herba Saussureae Involueratae is made powder, and sieve, such as No. 3 sieve (355 ± 13 μm of sieve pore internal diameters；50 mesh)；
Ultrasonic extraction is carried out with the water of about 30-50 times for example, about 35-45 times such as about 40 times weight of Herba Saussureae Involueratae or aqueous medium, such as from about
20-40min, preferably from about 30min；Centrifugal treating obtains supernatant.Centrifugation can be carried out in 5000 × g, such as 5-15min, such as
10min。
Optionally, said extracted and centrifugation step repeat, such as are repeated one or more times, and then will repeat the upper of extraction
Clear liquid is collected together.
After collecting supernatant, optionally water or aqueous medium can be added to be settled to about 0.001-0.1g crude drugs/ml, for example, about
0.001-0.1g crude drugs/ml, about 0.002-0.09g crude drugs/ml, about 0.003-0.08g crude drugs/ml, about 0.004-0.07g lifes
Medicine/ml, about 0.005-0.06g crude drugs/ml, about 0.006-0.05g crude drugs/ml, about 0.007-0.04g crude drugs/ml, about 0.008-
0.03g crude drugs/ml, about 0.009-0.02g crude drugs/ml or about 0.01g crude drugs/ml.
Birds nest extract
Bird's nest for use in the present invention is not particularly limited, but can use various types of bird's nests.Available for this hair
Bright bird's nest raw material can be all kinds of bird's nests that are commercially available and naturally harvesting, such as, but not limited to the white bird's nest in Indonesia room, example
Such as the white swallow small cup of Indonesia and the white swallow item of the white swallow item of Indonesia and white bird's nest such as Thailand of Thailand etc..
The birds nest extract of the present invention can be water extract.Those skilled in the art can take the common skill of this field
Art means obtain birds nest extract for use in the present invention.For example, for bird's nest water extract, workable extracting method does not have
Especially limitation, as long as it can fully extract the water soluble ingredient contained in bird's nest, such as hydro-thermal method extraction.
In a specific embodiment, hydro-thermal method comprises the following steps：Bird's nest is soaked in water or aqueous medium；Filtering
Obtain bird's nest filter residue；Obtained bird's nest filter residue is stewed in water or aqueous medium；Be filtered to remove the bird's nest filter residue through stewing
To obtain birds nest extract.
Further, hydro-thermal process includes adding in water or aqueous medium immersion foot so that bird's nest is former to bird's nest raw material
Expect a period of time of expansion, for example, at least 1 it is small when for example, at least 2 or 3 it is small when, be then filtered to remove water or aqueous medium, and
The expanded bird's nest of 85 degrees Celsius or more of temperature boiling for a period of time, for example, at least 3 it is small when, at least 4 it is small when, it is at least 5 small
When, at least 6 it is small when and up to 10 it is small when.In an illustrative embodiments, every kilogram of bird's nest raw material is risen with about 80-200
When water or small aqueous medium immersion expansion at least three, water or aqueous medium are filtered to remove afterwards, and adds in every kilogram of bird's nest raw material
The water or aqueous medium that about 20-40 rises, are then heated to about 85 degrees Celsius or more, stew at least about 6 hours, filter afterwards
Remove the bird's nest after stewing.
After removing the bird's nest after stewing, optionally water or aqueous medium can be added to be settled to about 0.001-0.1g crude drugs/ml, example
Such as from about 0.001-0.1g crude drugs/ml, about 0.002-0.09g crude drugs/ml, about 0.003-0.08g crude drugs/ml, about 0.004-0.07g
Crude drug/ml, about 0.005-0.06g crude drugs/ml, about 0.006-0.05g crude drugs/ml, about 0.007-0.04g crude drugs/ml, about
0.008-0.03g crude drugs/ml, about 0.009-0.02g crude drugs/ml or about 0.01g crude drugs/ml.
The preprocess method that this field routine may be employed in bird's nest raw material is pre-processed.It, can be first through anti-for hair swallow
Multiple rinsing removes surface contaminants and the down of surface attachment.For that through processed bird's nest, then can be directly added into water and be soaked
Bubble expansion.
In a specific embodiment, bird's nest water extract is made by the steps：
A) with about 50-150 times weight of bird's nest weight, for example, about 60,70,80,90,100,110,120,130 or 140
Times, the water of preferably 100 times weight or aqueous medium when for example impregnating bird's nest at room temperature about 1-5 being small, preferably from about 3 it is small when, filtering
Obtain bird's nest filter residue；And
B) swallow is stewed with about 20-40 times weight of bird's nest, the water of for example, about 25-35 times, preferably 30 times weight or aqueous medium
When nest filter residue is when about 4-8 is small, for example, about 5-7 is small, preferably from about 6 it is small when, bird's nest extracting solution, i.e. water extract is obtained by filtration.
The bird's nest extracting solution obtained can be converted into other forms through any known means in this field.It is such as freeze-dried
Powder type is converted into, to be suitble to different special-purposes.
Fig. 1 shows the exemplary process flow of a composition for preparing the present invention.
Composition
Combination of the present composition based on Herba Saussureae Involueratae extract and birds nest extract.
Water extraction or alcohol extracting can be used in Herba Saussureae Involueratae extract, and birds nest extract can be that water extracts in the present invention
Object.
In one aspect, the weight ratio of Herba Saussureae Involueratae extract contained in the present composition and birds nest extract exists
About 5:1 to 1:2 scope, preferably from about 5:1 to 1:1, for example, about 5:1、4.5:1、4:1、3.5:1、3.4:1、3.3:1、3.2:1、
3.1:1、3:1、2.9:1、2.8:1、2.7:1、2.6:1、2.5:1、2:1、1.5:1、1:1、1:1.5 and 1:2, such as 3:1.
In one aspect, the concentration of Herba Saussureae Involueratae extract is 0.001-0.1g crude drugs/ml, and for example, about 0.001-0.1g gives birth to
Medicine/ml, about 0.002-0.09g crude drugs/ml, about 0.003-0.08g crude drugs/ml, about 0.004-0.07g crude drugs/ml, about 0.005-
0.06g crude drugs/ml, about 0.006-0.05g crude drugs/ml, about 0.007-0.04g crude drugs/ml, about 0.008-0.03g crude drugs/ml,
About 0.009-0.02g crude drugs/ml or about 0.01g crude drugs/ml.
In one aspect, the concentration of birds nest extract is about 0.001-0.1g crude drugs/ml, and for example, about 0.001-0.1g gives birth to
Medicine/ml, about 0.002-0.09g crude drugs/ml, about 0.003-0.08g crude drugs/ml, about 0.004-0.07g crude drugs/ml, about 0.005-
0.06g crude drugs/ml, about 0.006-0.05g crude drugs/ml, about 0.007-0.04g crude drugs/ml, about 0.008-0.03g crude drugs/ml,
About 0.009-0.02g crude drugs/ml or about 0.01g crude drugs/ml.
In a specific embodiment, Herba Saussureae Involueratae extract is the Herba Saussureae Involueratae water that concentration is about 0.01g crude drugs/ml
Extract, birds nest extract are the bird's nest water extract that concentration is about 0.01g crude drugs/ml, and Herba Saussureae Involueratae extract and bird's nest
The weight ratio of extract is about 3:1.
In a specific embodiment, the composition is about 3.5 comprising weight ratio:1-2.5:1 (such as 3.4:1、
3.3:1、3.2:1、3.1:1、3:1、2.9:1、2.8:1、2.7:1、2.6:1) Herba Saussureae Involueratae water extract and the extraction of bird's nest water
Object, and the concentration of Herba Saussureae Involueratae extract is about 0.006g crude drugs/ml to 0.015g crude drugs/ml (for example, about 0.007-
0.014g crude drugs/ml, 0.008-0.013g crude drug/ml, 0.009-0.012g crude drug/ml, 0.010-0.011g crude drug/ml), and
The concentration of bird's nest water extract be about 0.006g crude drugs/ml to 0.015g crude drugs/ml (for example, about 0.007-0.014g crude drugs/ml,
0.008-0.013g crude drugs/ml, 0.009-0.012g crude drug/ml, 0.010-0.011g crude drug/ml).
It will be apparent to those skilled in the art that the two volume ratio can be moderately adjusted with extract concentrations difference, and can
It is expected that the composition so after adjustment can realize synergistic effect in terms of anti-oxidant/anti-aging and compared with individual day
For the Saussurea involucrata extract of mountain, improve whitening effect.
For example, when prepared Herba Saussureae Involueratae aqueous extract constant volume is about 0.01g crude drugs/ml, prepared bird's nest
Aqueous extract constant volume is 0.01g crude drugs/ml, by the two for example by mixing with such as weight ratio/volume ratio 3:1 combination is one
It rises.With the weight ratio correspondingly, when prepared Herba Saussureae Involueratae aqueous extract constant volume is about 0.03g crude drugs/ml, and prepared
Bird's nest aqueous extract constant volume be 0.01g crude drugs/ml when, by the two with such as 1:1 volume ratio mixes.
As used in this article, unit " g crude drugs/ml " refers to the g numbers for the raw material that every ml extracting solutions contain.
As used in this article, term " about " represented when for limiting numerical value shown in numerical value ± 5% scope, such as
± 4%, ± 3%, ± 2% or ± 1%.
It will be understood by those skilled in the art that be related to present composition and products thereof and preparation process not herein specifically
The known technology means of this field can be used in bright details.For example, birds nest extract and Herba Saussureae Involueratae extract are mixed when referring to
During conjunction, mixed media commonly used in the art can be used, such as mechanical mixture, be stirred, be applicable in the automatic mixed of automation process
Close etc..For example, the water for being used to prepare water extract, which can be this fields such as tap water, spring, mineral water, distilled water, commonly uses water.
For another example, Herba Saussureae Involueratae powder, such as lapping mode is made in the means of common techniques that this field can be used.
Composition according to the invention can only contain Herba Saussureae Involueratae extract and birds nest extract, can also be according to institute's phase
Other effects hoped contain other beneficiating ingredients and can also according to the purposes of composition (such as cosmetics, food,
Health products etc.), selection is containing the auxiliary element such as acceptable carrier, to realize other in addition to anti-oxidant and whitening
Effect, wherein the weight proportion of the Herba Saussureae Involueratae extract and birds nest extract is within the scope of the present invention.
For example, depending on actual needs, composition of the invention can also be with pharmaceutical carrier and/or other medicines active ingredient
Compounding pharmaceutical together.The composition of the present invention can also be prepared cosmetically together with cosmetics carrier and/or other active ingredients
Product；As food additive for health products, food, beverage etc.；Nutriment is used for as nutrition fortifier.
It will further be appreciated by those of ordinary skill in the art that the composition of the present invention may be directly applied to different purposes, it also can conduct
Different product, the raw material of different application are applicable in, it is further processed into different products, it is widely used.
Composition or product based on the present invention can be presented in a variety of manners, such as drug, health products, food, beverage, food
Product additive, nutrition fortifier or cosmetic products.
Direct-edible or other means the subject such as people for being applied to needs of the composition or product of the present invention, example
Such as, subject can be supplied to by way of for example oral or external such as topical application in vivo.
Herba Saussureae Involueratae is all the rare precious Chinese herbal medicine of tradition with bird's nest.Herba Saussureae Involueratae originates in Tianshan Mountains 3,000-4,000
The high cryogenic region of meter, due to manually a large amount of excavations, wild resource is increasingly exhausted, in addition manually culture is difficult, causes high quality
Herba Saussureae Involueratae yield it is few.The present invention is applied in combination by Herba Saussureae Involueratae and bird's nest, can not only reduce the use of Herba Saussureae Involueratae
Amount, and unexpected synergistic effect is generated in terms of anti-oxidant/anti-aging.The compatibility can not only significantly increase Tianshan Mountains
Anti-oxidant/anti-aging effects of saussurea involucrata, while the whitening effect of the composition comprising the compatibility is also enhanced, it can be widely used in
Relevant party face and product such as drug, health products, food and beauty product.The preparation method step letter of the present composition
It is single, easy to operate, preparation process is greatly simplified, is conducive to industrialized production.
Herba Saussureae Involueratae is even more the breakthrough that north and south medication combines in addition to the cooperative compensating in effect with bird's nest.Invention
People is equipped with the Herba Saussureae Involueratae for originating from the extremely cold ground Tianshan Mountains mountain top in the north of a desert for the bird's nest on Indonesia Java Island in cave,
The example that this breakthrough combination will be developed as new Resources of Chinese Traditional Drugs backward.
Embodiment
Below with reference to specific embodiment, the present invention will be described in detail.However, skilled in the art realises that, institute
Specific embodiment is stated only for clearly explaining the present invention, is all not construed as any limitation of the invention anyway.
Unless stated otherwise, all reagents and equipment is commercially available and all contents are by weight calculation.
Embodiment 1：The preparation of extract
The Herba Saussureae Involueratae 10g of the natural Herba Saussureae Involueratae farm of Xinjiang Tianshan is taken, is ground to powder, crosses No. 3 sieves.It is avenged with Tianshan Mountains
The water (400mL) of 40 times of weight of lotus carries out ultrasonic extraction 30min；After centrifuging 10min using 5000 × g, supernatant is collected；It repeats
Above-mentioned steps.After collecting supernatant twice, water is added to be settled to 0.010g crude drugs/ml (being settled to 1L), Herba Saussureae Involueratae is obtained and carries
Take liquid.
The white bird's nest 10g in Indonesia room is taken, with the water (1L) of its 100 times of weight when soaking at room temperature bird's nest 3 is small, mistake
Filter, obtains bird's nest filter residue；With the water (300mL) of 30 times of weight of bird's nest stew bird's nest filter residue 6 it is small when；Filtering removes the swallow after stewing
Nest residue adds water to be settled to 0.010g crude drugs/ml (being settled to 1L), obtains bird's nest extracting solution.
Embodiment 2：Antioxidant effect is tested
Standard curve is established with the anti-copper ion oxidability of TROLOX (analog of vitamin E) a kind of, and according to
The standard curve calculates the total antioxidant capacity of different birds nest extracts and Herba Saussureae Involueratae extract.In the test,
TROLOX equivalences are higher, and the oxidation resistance of institute's Test extraction object is better (see Fig. 2).
Embodiment 3：The synergistic effect of Herba Saussureae Involueratae extract and birds nest extract
This example demonstrates that the synergy of Herba Saussureae Involueratae extract and birds nest extract in oxidation resistance.
Herba Saussureae Involueratae extract, birds nest extract and the Herba Saussureae Involueratae extract prepared according to embodiment 1 is weighed respectively
Weight ratio with birds nest extract is 1:1、3:1 and 5:1 composition.Oxidation resistance test is carried out by following experiment packet,
With comparative composition compared with the effect of independent component.
Control group：To be added without the water of any tester as blank control
Group 1：1:1 group
a：The composition of 12 parts by weight (i.e. 1 gram) Herba Saussureae Involueratae extract and 12 parts by weight (i.e. 1 gram) birds nest extract
b：12 parts by weight (i.e. 1 gram) Herba Saussureae Involueratae extract and the water for supplementing 12 parts by weight (i.e. 1 milliliter)
c：12 parts by weight (i.e. 1 gram) birds nest extract and the water for supplementing 12 parts by weight (i.e. 1 milliliter)
Group 2：3:1 group
a：The composition of 18 parts by weight (i.e. 1.5 grams) Herba Saussureae Involueratae extract and 6 parts by weight (i.e. 0.5 gram) birds nest extract
b：18 parts by weight (i.e. 1.5 grams) Herba Saussureae Involueratae extract and the water for supplementing 6 parts by weight (i.e. 0.5 milliliter)
c：6 parts by weight (i.e. 0.5 gram) birds nest extract and the water for supplementing 18 parts by weight (i.e. 1.5 milliliters)
Group 3：5:1 group
a：The combination of 20 parts by weight (i.e. 1.67 grams) Herba Saussureae Involueratae extract and 4 parts by weight (i.e. 0.33 gram) birds nest extract
Object
b：20 parts by weight (i.e. 1.67 grams) Herba Saussureae Involueratae extract and the water for supplementing 4 parts by weight (i.e. 0.33 milliliter)
c：4 parts by weight (i.e. 0.33 gram) birds nest extract and the water for supplementing 20 parts by weight (i.e. 1.67 milliliters)
Every group of experiment set three it is parallel, and to repeat the average value of experiment three times as test result.
Test result is as shown in Figure 3.As it can be seen that the birds nest extract for the different ratio tested and Herba Saussureae Involueratae extract
Combination shows the oxidation resistance of collaboration.
Alternate test has been carried out using the bird's nest in other sources, it is found that the synergistic effect is not only restricted to the specific source of bird's nest
(data are not shown).Specific theory is not limited to, inventor speculates this uniformity with bird's nest in terms of its anti-oxidation efficacy, thus
The uniformity for playing the active ingredient of anti-oxidation efficacy is relevant.
Embodiment 4：The whitening effect test of the composition of Herba Saussureae Involueratae extract and birds nest extract
The test of tyrosinase activity inhibitory action is the conventional test methodologies for testing whitening effect.Wherein tyrosine
Levodopa (L-DOPA) can be changed into because of the effect of tyrosinase, be then converted into as dopachrome (Dopachrome).
Dopachrome has absorbance under 492nm wavelength, therefore can quantify and calculate the activity of tyrosinase.Dopachrome is simply temporary
Storage, it can change into melanin (Melanin).As it was noted above, the melanin on human skin is by melanocyte
(Melanocytes) dopachrome is transformed caused by.
The present embodiment using this field routine the test of tyrosinase activity inhibitory action, wherein by 0.5mM levodopas
It is placed in the sodium radio-phosphate,P-32 solution of 50mM pH 6.8, tyrosinase concentration is 0.2mg/mL, is for the control or sample size of test
200μL.It could be used without adding in the water of any extract as blank control, using the group that 1a, group 2a and group 3a are organized in embodiment 3
Close Herba Saussureae Involueratae extract (i.e. 2 grams of Herba Saussureae Involuerataes that each 24 parts by weight of object and individual 24 parts by weight are prepared according to embodiment 1
Extract) as different test samples.
Control and different test samples are put in 96 orifice plates, 20 minutes are stood under conditions of room temperature and without light,
Plate device reads absorbance under 492nm wavelength in terms of again, calculates inhibiting rate of the different test samples to tyrosinase.
Every group of test setting three is parallel, takes and repeats the average value of experiment three times as test result.Test result is shown in
Fig. 4.As it can be seen that compared to individual Herba Saussureae Involueratae extract, the whitening effect of different ratio composition is significantly improved.This
Show the present composition bring cooperate with beneficial antioxidation while, additionally it is possible to give full play to whitening function.
If the application proves, the present invention with bird's nest cooperation Herba Saussureae Involueratae use, by cooperate with it is beneficial in a manner of give full play to
The whole oxidation resistance and whitening effect of formula.And preparation process of the present invention is simple, and can economization cost, can more protect
Protect the natural precious resources of wild Herba Saussureae Involueratae increasingly in short supply.Meanwhile in the case of current natural resources of Chinese medicinal materials increasingly shortage, this hair
Bright combination application Herba Saussureae Involueratae is even more a perspective novelty of tool with the cross-border compatibility in this very rare north and south of bird's nest
Solution.
As previously mentioned, combined one or more embodiments has been explained in detail in the present invention in detail.It therefore however, can not be
And it is interpreted as the limitation to the scope of the claims of the present invention.It should be pointed out that for those of ordinary skill in the art, not
Several modifications and improvements can be made to the present invention on the premise of the spirit and substance of the present invention, these belong to the present invention
Protection domain.
Claims (13)
1. a kind of composition, it includes Herba Saussureae Involueratae extract and birds nest extracts.
2. composition described in claim 1, wherein the Herba Saussureae Involueratae extract is Herba Saussureae Involueratae water extract, and the swallow
Nest extract is bird's nest water extract.
3. the composition described in claim 1 or 2, wherein the weight ratio of the Herba Saussureae Involueratae extract and birds nest extract is about
5:1 to 1:2 scope.
4. the composition described in claim 3, wherein the weight ratio of the Herba Saussureae Involueratae extract and birds nest extract be selected from by
5:1、3:1 and 1:The group of 1 composition.
5. the composition described in claim 2, wherein the Herba Saussureae Involueratae water extract is prepared by following steps：
Herba Saussureae Involueratae is provided；
Ultrasonic extraction is carried out in water or aqueous medium；With
Residue is removed, to obtain Herba Saussureae Involueratae water extract.
6. the composition described in claim 2, wherein the bird's nest water extract is prepared by following steps：
Bird's nest is soaked in water or aqueous medium；
Remove liquid；
Water or aqueous medium stew it is soaking after bird's nest；With
The bird's nest through stewing is removed to obtain bird's nest water extract.
7. claim 1-6 any one of them compositions, do not include the Herba Saussureae Involueratae extract and birds nest extract it
Outer extract or active ingredient.
8. a kind of for anti-oxidant and/or whitening product, it includes claim 1-7 any one of them compositions.
9. purposes of the claim 1-7 any one of them composition in preparing for anti-oxidant and/or whitening product.
10. purposes of the claim 1-7 any one of them composition in anti-oxidant and/or whitening.
11. claim 1-7 any one of them compositions, are used for anti-oxidant and/or whitening.
12. a kind of anti-oxidant and/or whitening method, including applying claim 1-7 any one of them groups to subject
Close object.
13. a kind of method for preparing claim 1-7 any one of them compositions, including：
A) Herba Saussureae Involueratae extract and birds nest extract are provided；And
B) by the Herba Saussureae Involueratae extract and the birds nest extract with about 5:1 to 1:2 weight ratio mixing.
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| CN104784507A (en) * | 2015-04-12 | 2015-07-22 | 广州市中旺生物科技有限公司 | Traditional Chinese medicine composition with multiple cosmetic effects and application |
| CN106360696A (en) * | 2016-09-18 | 2017-02-01 | 大连普瑞康生物技术有限公司 | Food composition containing tissue culture of saussurea involucrate and cubilose |
| CN106562428A (en) * | 2016-10-17 | 2017-04-19 | 武汉龙族药号生物医药科技有限公司 | Facial beautification and body shaping soft extract and preparation method thereof |
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| CN103479670A (en) * | 2013-08-30 | 2014-01-01 | 香港科技大学 | Cubilose extracting solution as well as preparation method and application thereof |
| CN104258080A (en) * | 2014-10-16 | 2015-01-07 | 石如荟 | Traditional Chinese medicine for treating endocrine dyscrasia |
| CN104434694A (en) * | 2014-12-11 | 2015-03-25 | 唯美度科技（北京）有限公司 | Beauty-maintaining face applying cream containing saussurea involucrate extract |
| CN104784507A (en) * | 2015-04-12 | 2015-07-22 | 广州市中旺生物科技有限公司 | Traditional Chinese medicine composition with multiple cosmetic effects and application |
| CN106360696A (en) * | 2016-09-18 | 2017-02-01 | 大连普瑞康生物技术有限公司 | Food composition containing tissue culture of saussurea involucrate and cubilose |
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