CN104510700A - Manufacturing method for anti-wrinkling and skin whitening used raw herb extracts, and anti-wrinkling and skin whitening used cosmetic composition containing raw herb extracts - Google Patents

Manufacturing method for anti-wrinkling and skin whitening used raw herb extracts, and anti-wrinkling and skin whitening used cosmetic composition containing raw herb extracts Download PDF

Info

Publication number
CN104510700A
CN104510700A CN201410361819.0A CN201410361819A CN104510700A CN 104510700 A CN104510700 A CN 104510700A CN 201410361819 A CN201410361819 A CN 201410361819A CN 104510700 A CN104510700 A CN 104510700A
Authority
CN
China
Prior art keywords
extract
skin
wrinkle resistant
medicinal herbs
raw medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410361819.0A
Other languages
Chinese (zh)
Inventor
郑永哲
黄相圭
崔准珉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International University Of Korea Industry & Academy Cooperation Foundation
HAMYANG WILD GINSENG
Original Assignee
International University Of Korea Industry & Academy Cooperation Foundation
HAMYANG WILD GINSENG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International University Of Korea Industry & Academy Cooperation Foundation, HAMYANG WILD GINSENG filed Critical International University Of Korea Industry & Academy Cooperation Foundation
Publication of CN104510700A publication Critical patent/CN104510700A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a manufacturing method for anti-wrinkling and skin whitening used raw herb extracts. The method includes: a first step of adding a mixed solvent into transplanted ginseng, Rhodiola rosea, Saussurea involucrate and Cordyceps sinensis separately to manufacture transplanted ginseng extract, Rhodiola rosea extract, Saussurea involucrate extract and Cordyceps sinensis extract; a second step of filtering and concentrating the transplanted ginseng extract, Rhodiola rosea extract, Saussurea involucrate extract and Cordyceps sinensis extract; and a third step of mixing cultured ginseng root concentrate with the transplanted ginseng extract, Rhodiola rosea extract, Saussurea involucrate extract and Cordyceps sinensis extract to obtain the anti-wrinkling and skin whitening used raw herb extracts. According to the utility model, the transplanted ginseng extract, cultured ginseng root concentrate, Rhodiola rosea extract, Saussurea involucrate extract and Cordyceps sinensis extract are used at the same time, so that through the combination of the five raw herbs, the anti-wrinkling and skin whitening effects are far better than the effects of using the raw herbs separately.

Description

The manufacture method of skin wrinkle resistant whitening raw medicinal herbs extract and the wrinkle resistant whitening cosmetic preparation constituent containing raw medicinal herbs extract
Technical field
The present invention relates to the manufacture method of a kind of skin wrinkle resistant whitening raw medicinal herbs extract and the skin wrinkle resistant whitening cosmetic preparation constituent containing described raw medicinal herbs extract, particularly relate to one and use five kinds of raw medicinal herbs such as Transplant Wild Ginseng extract, mountain ginseng culture root concentrated solution, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract simultaneously, produce comprehensive effect, make wrinkle resistant and whitening effect than the manufacture method of skin better when being used alone wrinkle resistant whitening raw medicinal herbs extract and the skin wrinkle resistant whitening cosmetic preparation constituent containing described raw medicinal herbs extract.
Background technology
Melanic generation, mainly in order to resist the damage of ultraviolet to skin, protects skin.Melanic biosynthetic process is as follows: tyrosine (Tyrosine) starts oxidation under the effect of tryrosinase (Tyrosinase), is generated after generating dihydroxyphenylalanine (DOPA) and dopachrome (DOPAchrome) by DHICA and DHI.The black generated have DHI melanin (DHI-eumelanin), DHICA melanin (DHICA-eumelanin), PHEO melanin (Pheomelanin) etc. three kinds.Skin darkening is that melanin passes to keratinocyte (keratinocyte: keratinocyte) and is deposited on skin epidermis and formed.
The melanism deposition of skin is the main cause generating nevus, freckle, black speck etc., in order to prevent and improve skin melanism as above, develop the whitening agents such as kojic acid (kojic acid), Arbutin (Arbutin), vitamin C (Vitamin C) derivant.But kojic acid is inferior to the inhibition that melanin generates in cell or body the inhibition of Tyrosinase in vivo, and according to current research report, life-time service kojic acid can cause hepatocarcinoma; Arbutin has the cytotoxicity that hydroquinone (hydroquinone) series has; As for vitamin C, be difficult to long-term keeping because there is the problem of chemical stability aspect.Therefore, the good whitening agent of development effectiveness is badly in need of.
Along with the side effect of whitening active material is disclosed, people start, to utilizing the functional whitening material of various natural extract to study, with alternative whitening active material, and to adopt Cortex Mori, Radix Trichosanthis extract, Semen phaseoli radiati etc. as whitening raw material.But effect or the toxicity of these raw materials all do not obtain accurate validation.
No. 10-0863449th, Korean granted patent publication (2008.10.16) discloses the functional cosmetics of Cordyceps as main material, whitening effect excellence; No. 10-0493845th, Korean granted patent publication (2005.06.08) discloses the whitening cosmetic preparation constituent of the SHANSHEN adventitious root extract containing tissue culture; No. 10-0445404th, Korean granted patent publication (2004.08.25) discloses the whitening constituent comprising Radix Rhodiolae extract; No. 10-0513902nd, Korean granted patent publication (2005.09.07) discloses the skin anti-aging cosmetic preparation constituent including Transplant Wild Ginseng extract; No. 10-0561036th, Korean granted patent publication (2006.03.20) discloses external preparation for skin constituent Herba Saussureae Involueratae extract as effective ingredient with skin anti-aging function.But cosmetic preparation as above or skin protectant all reduce owing to tiring and cause its effect not good, strong to the zest of skin.
Summary of the invention
The object of the invention is to make up the deficiencies in the prior art, there is provided one to utilize five kinds of raw medicinal herbs such as Transplant Wild Ginseng extract, mountain ginseng culture root concentrated solution, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract simultaneously, strengthen the manufacture method of its skin that is wrinkle resistant and whitening effect wrinkle resistant whitening raw medicinal herbs extract, the raw drug extract manufactured by the method and the skin wrinkle resistant whitening cosmetic preparation constituent containing raw medicinal herbs extract by its comprehensive effect.
The technical solution used in the present invention is as follows in order to achieve the above object:
The manufacture method of skin of the present invention wrinkle resistant whitening raw medicinal herbs extract comprises: the first stage, manufacture the stage of Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract respectively to Transplant Wild Ginseng, Radix Rhodiolae, Herba Saussureae Involueratae and Cordyceps add mixed solvent; Second stage, the stage of filtration and concentrated Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract; And the phase III, in the ginseng culture root concentrated solution of mountain, mix described concentrated Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract and manufacture stage of skin wrinkle resistant whitening raw medicinal herbs extract.
In the described first stage, respectively 5 ~ 10 times of (W/W) mixed solvents are added to a certain amount of described Transplant Wild Ginseng, Radix Rhodiolae, Herba Saussureae Involueratae and Cordyceps, and extract 4 ~ 6 hours at 75 ~ 85 DEG C of temperature.
Described mixed solvent is mixed with 6:4 ~ 5:5 volume ratio by ethanol (Ethanol) and water and is made.
In described second stage, filter described Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract, after removing solids, make solids content reach 20Brix with concentrating under reduced pressure machine concentrated remaining liquid at 60 DEG C of temperature.
In the described phase III, mix described mountain ginseng culture root concentrated solution, Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract with 1:1:1:1:1 weight ratio.
By the skin wrinkle resistant whitening raw medicinal herbs extract that above-mentioned any one skin wrinkle resistant whitening raw medicinal herbs extract manufacture method manufactures.
Described skin wrinkle resistant whitening raw medicinal herbs extract is 0.1 ~ 0.5 percentage by weight as the content of effective ingredient in cosmetic preparation constituent.
Described skin wrinkle resistant whitening cosmetic preparation constituent dosage form is any one in astringent, essence, emulsion, cream.
The beneficial effect that the present invention contains the skin wrinkle resistant whitening cosmetic preparation constituent of raw medicinal herbs extract is: utilize Transplant Wild Ginseng extract, mountain ginseng culture root concentrated solution, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract simultaneously, by the comprehensive effect of described five kinds of raw medicinal herbs, make its wrinkle resistant and whitening effect considerably beyond effect when using above-mentioned raw medicinal herbs respectively.
Accompanying drawing explanation
Fig. 1 is the skin photo before experiment.
Fig. 2 is skin photo when just having removed adhesive plaster.
Fig. 3 removes the skin photo of adhesive plaster after one hour.
Detailed description of the invention
The following detailed description of the present invention.
First, the manufacture method of skin of the present invention wrinkle resistant whitening raw medicinal herbs extract is described.
The manufacture method of skin of the present invention wrinkle resistant whitening raw medicinal herbs extract comprises: the first stage, add mixed solvent respectively to Transplant Wild Ginseng, Radix Rhodiolae, Herba Saussureae Involueratae and Cordyceps and extract, manufacturing the stage of Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract; Second stage, the stage of filtration and concentrated Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract; Phase III, in the ginseng culture root concentrated solution of mountain, mix concentrated Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract, manufacture the stage of the wrinkle resistant and whitening raw medicinal herbs extract of skin.
The described first stage, preferably add the mixed solvent of 5 ~ 10 times (W/W) respectively to a certain amount of described Transplant Wild Ginseng, Radix Rhodiolae, Herba Saussureae Involueratae and Cordyceps, and extract 4 ~ 6 hours at 75 ~ 85 DEG C of temperature.
Ethanol (Ethanol) and water are preferably made with the mixing of the volume ratio of 6:4 ~ 5:5 by described mixed solvent.When ethanol content exceedes aforementioned proportion, can be affected as its stability of cosmetic raw materials; When ethanol content is less than aforementioned proportion, it extracts ratio and can greatly reduce.
Radix Ginseng seed is sprinkling upon wild cultivation on mountain and forms by the Transplant Wild Ginseng (formal name used at school: Panax ginseng C.A.Meyer) used in the present invention, usually supports ginseng also referred to as long brain, long brain SHANSHEN or mountain.Why be called that long brain is because the brain connecting stem and root is longer.Mountain grows under supporting the sandalwood and paint wood that ginseng is easy in the shade in remote mountains, dampness is large, and be mostly grown on shady and cool and remote place, its profile is not only similar in appearance to natural SHANSHEN, and drug effect is also equivalent to natural SHANSHEN.More than common Radix Ginseng 3-4 times of the content of physiologically active ingredient ginsenoside (ginsenoside) Rg1 in ginseng is supported on mountain.The organic germanium and Fructus Gleditsia that are rich in pharmacological action brilliance are supported in ginseng in mountain.The root that ginseng is supported on mountain has excellent drug effect, can be used for strengthening body resistance and immunity, and the various adult disease such as prevention glycosuria, cancer, blood pressure, enhance metabolism, improve cerebral activity, keeps full of vitality etc.Further, also there is the effect of protection the five internal organs, tranquilizing by nourishing the heart, to human body, there is various beneficial effect.
The Radix Rhodiolae (formal name used at school: Rhodiola Sachalinensis A.Bor) used in the present invention is the herbaceos perennial of the alpine belt inhabiting height above sea level about 2000 ~ 5000m.Radix Rhodiolae growing environment is severe, and also can survive in, drying large at day and night temperature, anoxia, alpine belt that ultraviolet is strong, thus have very strong vitality and special adaptive capacity, therefore, also referred to as high mountain Herba hylotelephii erythrosticti or Radix Rhodiolae etc.The main component of Radix Rhodiolae is that master comprises starch, protein, fat, sugar, flavone compound, aminoacid, inorganic elements, micro-quintessence oil etc. with salidroside (salidroside), butyl alcohol (tyrosol) and glucoside.
Herba Saussureae Involueratae (the formal name used at school: Herba Sauaaureae Involucratae used in the present invention, English name: Snow Lotus) also referred to as snow Flos Nelumbinis, be in the Mountain Ranges of Tian Shan Mountains in Xinjiang Uygur area, the medicinal plants of Compositae that just can excavate of some areas of the Himalayas normal pulse Kunlun.It is mainly spontaneous on the overhanging cliff of the above perennial snow highlands of height above sea level 4000m, because habitat is badly not easily excavated, therefore, only have ancient times emperor and officials loyal to his sovereign could taste, be just called emperor medicinal herbs from ancient times.Herba Saussureae Involueratae is the needs time of 6 ~ 8 years from germinateing to blooming, florescence be July to August, needing to wait for time of several years to excavate Herba Saussureae Involueratae, therefore belonging to rare plant.The petal of described Herba Saussureae Involueratae is fewer than Flos Nelumbinis, thin, narrow and grow, and time flower is bloomed, the form of its gracefulness is like as Flos Nelumbinis, therefore claims it to be Herba Saussureae Involueratae.And the attitude not only spent is beautiful, joyful audience, and containing contributing to the effective ingredient of human body, therefore, claim it to be the king of BAICAO from ancient times.The kind of Herba Saussureae Involueratae has snow lotus of big bud flower, cotton head Herba Saussureae Involueratae, Saussurea medusa Maxim. etc.The spontaneous snow lotus of big bud flower in the Mountain Ranges of Tian Shan Mountains, Xinjiang Uygur area is the On behalf of plant of effect the best in Herba Saussureae Involueratae, also referred to as Herba Saussureae Involueratae.The flower of snow lotus of big bud flower, leaf, stem, root all have respective effect.The flower of cotton head Herba Saussureae Involueratae is like Cotton Gossypii, and it is from being born in the Himalaya.Saussurea medusa Maxim. mainly from being born in Qinghai Province one band, generally only uses its petal.The main constituent of described Herba Saussureae Involueratae contains 16 kinds of basic substances of the needed by human such as alkaloid (alkaloid), sterin (sterol), flavone (flavonoid), sterol, essential oil (essential oil), polysaccharide body.In addition, the strong effect of the nourishing of Herba Saussureae Involueratae is remarkable.
The Cordyceps (paceilomyces japonica) used in the present invention is the ascomycetes that insecticide forms sporophore.11 seed amino acids having human body to need in the composition of Cordyceps and medicative 10 seed amino acids of tool, account for more than 60% of total content respectively, and the isomer cordycepic acid (cordycepic acid) of quininic acid (quinic acid) accounts for 7%.Also there is the various pharmacological actions such as enhancing immunity in addition.
Described second stage, preferably after filtration described Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract remove solids, utilizes concentrating under reduced pressure machine concentrated remaining liquid at 60 DEG C of temperature, makes solids content reach 20Brix.
Preferably described mountain ginseng culture root concentrated solution, Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract is mixed with 1:1:1:1:1 weight ratio in the described phase III.
Described mountain ginseng culture root concentrated solution can use the mountain ginseng culture root concentrated solution that thick Saponin is more than 100mg/g, solids content is 70%.
The mountain ginseng culture root used in the present invention utilizes biological reflecting device and by tissue culture's product of automated system sterile production, without the dangerous substance such as pesticide and heavy metal in product, have good quality, and, the composition of composition and content by the impact of external environment condition, can not keep even.The effective ingredient of mountain ginseng culture root is the same with Radix Ginseng and Radix Ginseng Rubra is Fructus Gleditsia, is contained in more than 30 in Radix Ginseng and Radix Ginseng Rubra and plants Fructus Gleditsia composition and be equally also contained in the ginseng culture root of mountain, in addition, according to analysis, also containing its exclusive composition in the ginseng culture root of mountain.These compositions comprise the representative Fructus Gleditsia composition of the Radix Ginsengs such as glycol group Rb1, Rb2, Rc, Rd and triol group Rg1, Re, also comprise and enjoy because having the effects such as anticancer and enhancing immunity nonpolar group of Radix Ginseng Rubra specific component Rg3, Rg5 gazing in recent years.
In addition, the present invention also provides the skin manufactured by above-mentioned manufacture method wrinkle resistant whitening raw medicinal herbs extract.
The content of the effective ingredient raw medicinal herbs extract of skin of the present invention anti-wrinkle whitening cosmetic preparation constituent preferably accounts for 0.1 ~ 0.5% of cosmetic preparation constituent gross weight.If the content of described extract is less than 0.1 percentage by weight, just can not fully produce a desired effect; If the content of described extract is greater than 0.5 percentage by weight of cosmetic preparation gross weight, the stability of cosmetic preparation may go wrong, and thus, likely affects cosmetic preparation outward appearance or dressing effect.
To the dosage form of cosmetic preparation constituent containing the manufacture of raw medicinal herbs extract, there is no particular limitation, various basic adornment product and color make-up product can be manufactured, such as, astringent class, essence class, emulsion class, cream class, facial film class, vanishing cream class and sun screen class etc.
Further, appropriate described raw medicinal herbs extract and normally used in the art molding additive and additive can be comprised in described cosmetic preparation constituent.
Below by embodiment, composition of the present invention and effect are described in detail.This embodiment is only used to illustrate that the present invention illustrates, protection scope of the present invention is not limited to this embodiment.
[Production Example 1]
Extract 5 hours at 80 DEG C of temperature after adding mixed solvent 5 in Transplant Wild Ginseng 1Kg.Described mixed solvent is mixed by 2.6 ethanol (Ethanol) and 2.4 water.Filter described extract to remove after solids, carry out concentratedly making the content of solid reach 20 Brix to remaining liquid by concentrating under reduced pressure machine at 60 DEG C of temperature, manufacture Transplant Wild Ginseng extract with this.
[Production Example 2]
Replace the Transplant Wild Ginseng in described Production Example 1 with Radix Rhodiolae, other are all same as Production Example 1, obtain Radix Rhodiolae extract with this.
[Production Example 3]
Replace the Transplant Wild Ginseng in described Production Example 1 with Herba Saussureae Involueratae, other are all same as Production Example 1, obtain Herba Saussureae Involueratae extract with this.
[Production Example 4]
Replace the Transplant Wild Ginseng in described Production Example 1 with Cordyceps, other are all same as Production Example 1, obtain Cordyceps extract with this.
[experimental example 1]
Extraction result and the concentrated result of the Transplant Wild Ginseng extract manufactured in described Production Example 1 to Production Example 4, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract are as shown in table 1.
Table 1
[embodiment 1]
With 1:1:1:1:1 weight ratio, the Transplant Wild Ginseng extract manufactured in Production Example 1 to Production Example 4, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract are blended in Transplant Wild Ginseng cultivate in root concentrated solution, manufacture skin wrinkle resistant whitening raw medicinal herbs extract.Described Transplant Wild Ginseng cultivates that root concentrated solution employs thick more than Saponin 100mg/g that CBN biotechnology Co., Ltd. manufactures, solid contents is the product of 70%.
[experimental example 2]
The skin stability that is wrinkle resistant and skin-whitening raw medicinal herbs extract manufactured in embodiment 1 is evaluated.Wrinkle resistant and the skin-whitening raw medicinal herbs extract manufactured in embodiment 1 is melted in Tween 80/saline (1:99, u/v) soak in napkin (patch) after, be attached to the back of the hand of an experimenter, observed result after 24 hours, 48 hours, 72 hours.Its observed result is as shown in table 2.
Table 2
As shown in table 2, reflect without obvious erythema, therefore, can determine that the wrinkle resistant and skin-whitening raw medicinal herbs extract manufactured in embodiment 1 has no injury to skin.
[experimental example 3]
Wrinkle resistant and the stimulation degree of skin-whitening raw medicinal herbs extract to skin manufactured in embodiment 1 is evaluated.Utilization has irritating experiment adhesive plaster, fully soaks gauze portion and sticks to arm, after 24 hours, take away adhesive plaster with the wrinkle resistant and skin-whitening raw medicinal herbs extract manufactured by embodiment 1.Skin photo when just having taken away adhesive plaster as shown in Figure 2, takes away skin photo after adhesive plaster 1 hour as shown in Figure 3.Through with experiment before skin photo 1(Fig. 1) contrast, find to skin have no stimulation.
Analyze above-mentioned experimental result as follows: by of the present invention wrinkle resistant and skin-whitening raw medicinal herbs extract is applied to wrinkle resistant and skin-whitening cosmetic preparation constituent time, very little to the stimulation degree of skin, very safe to skin.

Claims (8)

1. a manufacture method for skin wrinkle resistant whitening raw medicinal herbs extract, is characterized in that: it comprises
First stage, manufacture the stage of Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract respectively to Transplant Wild Ginseng, Radix Rhodiolae, Herba Saussureae Involueratae and Cordyceps add mixed solvent;
Second stage, the stage of filtration and concentrated Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract; And
Phase III, in the ginseng culture root concentrated solution of mountain, mix described concentrated Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract and manufacture stage of skin wrinkle resistant whitening raw medicinal herbs extract.
2. the manufacture method of skin according to claim 1 wrinkle resistant whitening raw medicinal herbs extract, it is characterized in that: in the described first stage, respectively 5 ~ 10 times of (W/W) mixed solvents are added to a certain amount of described Transplant Wild Ginseng, Radix Rhodiolae, Herba Saussureae Involueratae and Cordyceps, and extract 4 ~ 6 hours at 75 ~ 85 DEG C of temperature.
3. the manufacture method of skin according to claim 2 wrinkle resistant whitening raw medicinal herbs extract, is characterized in that: described mixed solvent is mixed with 6:4 ~ 5:5 volume ratio by ethanol (Ethanol) and water and made.
4. the manufacture method of skin according to claim 1 wrinkle resistant whitening raw medicinal herbs extract, it is characterized in that: in described second stage, filter described Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract, after removing solids, solids content is made to reach 20Brix with concentrating under reduced pressure machine concentrated remaining liquid at 60 DEG C of temperature.
5. the manufacture method of skin according to claim 1 wrinkle resistant whitening raw medicinal herbs extract, it is characterized in that: in the described phase III, mix described mountain ginseng culture root concentrated solution, Transplant Wild Ginseng extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract and Cordyceps extract with 1:1:1:1:1 weight ratio.
6. by the skin wrinkle resistant whitening raw medicinal herbs extract of the manufacture of manufacture method any one of claim 1 to 5.
7. containing the skin wrinkle resistant whitening cosmetic preparation constituent of skin according to claim 6 wrinkle resistant whitening raw medicinal herbs extract, it is characterized in that: described skin wrinkle resistant whitening raw medicinal herbs extract is 0.1 ~ 0.5 percentage by weight as the content of effective ingredient in cosmetic preparation constituent.
8. the skin wrinkle resistant whitening cosmetic preparation constituent containing skin wrinkle resistant whitening raw medicinal herbs extract according to claim 7, is characterized in that: described skin wrinkle resistant whitening cosmetic preparation constituent dosage form is any one in astringent, essence, emulsion, cream.
CN201410361819.0A 2013-09-30 2014-07-28 Manufacturing method for anti-wrinkling and skin whitening used raw herb extracts, and anti-wrinkling and skin whitening used cosmetic composition containing raw herb extracts Pending CN104510700A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2013-0116385 2013-09-30
KR20130116385A KR20150037115A (en) 2013-09-30 2013-09-30 Manufacturing method of herb extracts for anti-wrinkling and skin whitening, herb extracts for anti-wrinkling and skin whitening manufactured by the same and cosmetic composition for anti-wrinkling and skin whitening containing the same

Publications (1)

Publication Number Publication Date
CN104510700A true CN104510700A (en) 2015-04-15

Family

ID=52786939

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410361819.0A Pending CN104510700A (en) 2013-09-30 2014-07-28 Manufacturing method for anti-wrinkling and skin whitening used raw herb extracts, and anti-wrinkling and skin whitening used cosmetic composition containing raw herb extracts

Country Status (2)

Country Link
KR (1) KR20150037115A (en)
CN (1) CN104510700A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943414A (en) * 2015-03-09 2016-09-21 韩国化妆品制造株式会社 Cosmetic composition comprising oil of cultured root of wild ginseng, method for preparing same and makeup method using same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200138870A (en) * 2019-06-03 2020-12-11 (주)피에스에이 Composition for preventing or improving skin aging comprising an extract of rhodiola sachalinesis fermented by bovista plumbea
KR102630938B1 (en) * 2023-08-23 2024-01-31 에프아이씨씨주식회사 Cosmetic compositions for skin regeneration, skin moisturization, and wrinkle improvement with improved skin permeability and component stability, and their manufacturing methods

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020031354A (en) * 2002-01-22 2002-05-01 한영환 Preparation of Whitening Materials from Cordyceps militaris
KR20020033034A (en) * 2001-06-21 2002-05-04 이충우 Skin cosmetics using long headed ginseng and mountain ginseng
KR20030012562A (en) * 2001-08-01 2003-02-12 주식회사 웰스킨 Whitening composition containing rhodiola sachalinensis a. bor extraction
JP2004155961A (en) * 2002-11-07 2004-06-03 Nippon Yakuyo Shokuhin Kenkyusho:Kk Antioxidant
CN101125119A (en) * 2007-07-18 2008-02-20 西藏宇妥藏药研究有限公司 Tibetan materia medica with whitening anti-senility function and application thereof
CN101249178A (en) * 2008-04-09 2008-08-27 四川省东圣酒业有限公司 Reinforced immunity and kidney tonifying health care medicinal liquor and preparing same thereof
CN102641235A (en) * 2012-05-18 2012-08-22 通德集团有限公司 Rhodiola crenulata essence with skin softening and anti-wrinkle effects

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020033034A (en) * 2001-06-21 2002-05-04 이충우 Skin cosmetics using long headed ginseng and mountain ginseng
KR20030012562A (en) * 2001-08-01 2003-02-12 주식회사 웰스킨 Whitening composition containing rhodiola sachalinensis a. bor extraction
KR20020031354A (en) * 2002-01-22 2002-05-01 한영환 Preparation of Whitening Materials from Cordyceps militaris
JP2004155961A (en) * 2002-11-07 2004-06-03 Nippon Yakuyo Shokuhin Kenkyusho:Kk Antioxidant
CN101125119A (en) * 2007-07-18 2008-02-20 西藏宇妥藏药研究有限公司 Tibetan materia medica with whitening anti-senility function and application thereof
CN101249178A (en) * 2008-04-09 2008-08-27 四川省东圣酒业有限公司 Reinforced immunity and kidney tonifying health care medicinal liquor and preparing same thereof
CN102641235A (en) * 2012-05-18 2012-08-22 通德集团有限公司 Rhodiola crenulata essence with skin softening and anti-wrinkle effects

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943414A (en) * 2015-03-09 2016-09-21 韩国化妆品制造株式会社 Cosmetic composition comprising oil of cultured root of wild ginseng, method for preparing same and makeup method using same

Also Published As

Publication number Publication date
KR20150037115A (en) 2015-04-08

Similar Documents

Publication Publication Date Title
KR101405429B1 (en) Cosmetics containing natural grass
JP5791879B2 (en) NF-κB activation inhibitor and pore care agent
CN104784507A (en) Traditional Chinese medicine composition with multiple cosmetic effects and application
JP5137457B2 (en) Stem cell growth factor expression increase inhibitor
KR101953779B1 (en) Method for producting chinese medicine composition and shampoo
KR101128564B1 (en) The manufacturing process of lithospermum erythrorhizon soap controlled by vineger
CN103002872A (en) Skin-whitening composition containing extracts from trees including paper mulberry
KR101516536B1 (en) Composition for Preventing Hair Loss and Promoting Hair Growth and A method for manufacturing thereof
KR100272463B1 (en) Extract extracted from natural substance for using in cosmetics
CN104510700A (en) Manufacturing method for anti-wrinkling and skin whitening used raw herb extracts, and anti-wrinkling and skin whitening used cosmetic composition containing raw herb extracts
CN102327200A (en) Whitening and freckle-removing product and preparation method thereof
CN107823004A (en) Plant composition with anti-sunlight function and its application in sunscreen product
KR20180137952A (en) Mask pack
KR100357416B1 (en) Compositions of whitening cosmetics containing special herbal extracts
CN1323655C (en) Cosmetic composition containing the extract of mountain ginseng adventitious roots
KR101948597B1 (en) Hair cosmetic composition with excellent cleansing effect and soothing effect
CN107773508A (en) A kind of facial mask and preparation method thereof
CN109125206A (en) A kind of extraction preparation method that dendrobium candidum drips liquid Normal juice and the application in cosmetics
KR102168533B1 (en) Cosmetic composition for whitening or improving the facial color containing herb extracts
KR20170136969A (en) Method for preparing natural extract using sugars
AU2012247916A1 (en) Chinese herbal extract, preparing method and application thereof
CN107773506A (en) A kind of eye sticker and preparation method thereof
KR101931952B1 (en) Cosmetical composition with anti-aging using natural plant extract and cosmetics comprising thereof
KR20100092922A (en) A skin whintening cosmetic composition containing a oriental herb extracts mixture stabilized by nanoliposome
KR100841276B1 (en) Skin Whitening Composition Containing Ethyl Acetate Fraction of White Ginseng with High Whitening Activity

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150415