CN106214592B - Hair follicle nutrient liquor composition and preparation method thereof - Google Patents
Hair follicle nutrient liquor composition and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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Abstract
Hair follicle nutrient liquor composition, on the basis of the total weight of the composition, the composition includes, hair follicle nutrient liquor composition, on the basis of the total weight of the composition, the composition includes: 0.001~5wt% includes the first of indoles hydrochlorate to educate hair functional component and 0.01~10wt% includes the second of Herba Swertiae bimaculatae extract to educate the solvent of hair functional component and surplus.It is curative for effect using the present composition, hair growth can be effectively facilitated, the negative effect of stimulation will not be fast and safely generated.
Description
Technical field
The invention belongs to daily chemicals field, in particular to a kind of composition and preparation method thereof of hair follicle nutrient solution.
Background technique
Hair problem in life generally includes: alopecia caused by seborrhea；Women postpartum alopecia, climacteric alopecia
Equal endocrines alopecia；Because of alopecia caused by losing weight, lacking the Nutrition and Metabolisms such as vitamin, malnutrition；Chemicotherapy, epifolliculitis cause
Pathologic alopecia；It washes shield product and selects improper, hair-waving, alopecia caused by the chemical stimulations such as hair dyeing；Biggish stress draws
The hair sparse that rises, withered and yellow, partially thin, soft, easily broken and hair is unhealthy etc..These alopecia problems not only influence appearance instrument,
It will also result in very big strike to the self-confidence of people.Human body hair follicle is the target organ to Androgen-sensitive, and the hero of human secretory swashs
Element is mainly testosterone, and testosterone is changed into protona under the action of 5- alpha-reductase, then with the hero in scalp portion hair follicle target cell
Hormone receptor combines, and inhibits the growth and development of papilla, interferes the growth metabolism of hair follicle cell, enters hair in advance and stops
Phase, so as to cause alopecia.In addition, groups of people, due to inherent cause, hair follicle is higher to the sensibility of androgen, swash in normal male
Plain level can equally cause alopecia.
In order to improve alopecia and promote the growth of hair, there is external application reactive protein in the prior art to nourish the side of hair follicle
Method, but effect is not significant.Hair follicle nutrient solution is very different on the market, and adverse reaction takes place frequently, and safety issue is prominent, irritation
Reaction, allergy, phototoxic reaction incidence are higher, therefore are highly desirable to by the way that specific hair follicle nutrient solution combination is arranged
Object, natural on-off cycles of hair growth can be promoted by not only wanting curative for effect, more will not fast and safely be generated negative effect, can be helped vast hair conscientiously
It sends out patient problematic and releases and is worried.
Summary of the invention
The object of the present invention is to provide a kind of hair follicle nutrient liquor compositions, on the basis of the total weight of the composition,
The composition includes: 0.001~5wt% includes the first of indoles hydrochlorate to educate hair functional component and 0.01~10wt%
It include the second of Herba Swertiae bimaculatae extract to educate the solvent of hair functional component and surplus.
Preferably, on the basis of the total weight of the composition, the composition includes:
0.001~5wt% includes the first of indoles hydrochlorate to educate hair functional component；
0.01~10wt% includes that radix-polygoni multiflori extract, Herba Swertiae bimaculatae extract, ginseng extract second educate hair effect
Ingredient；0.001~5wt% includes the antibacterial anti-inflammatory ingredient of licorice；
The solvent is the mixed liquor of second alcohol and water.
Preferably, the licorice includes dipotassium glycyrrhizinate, mono-ammonium glycyrrhizinate, Carbenoxolone Sodium, one potassium of glycyrrhizic acid
Salt, glycyrrhizin, licoflavone, diammonium glycyrrhizinate.
Preferably, the antibacterial anti-inflammatory ingredient also includes peony root extractive and ginger-root extract.
Preferably, the indoles hydrochlorate includes heteroauxin sodium, indolepopionic acid sodium, indolebutyric acid sodium, butyric acid potassium.
Preferably, described second educate hair functional component also include niacinamide, 6- benzylaminopurine, pentadecanoic acid glycerol
Ester, minoxidil, carpronium chloride, t- flavanones, hinokitiol and nicotinic acid benzyl ester, cutin growth factor KGF.
Preferably, the weight ratio of the licorice and indoles hydrochlorate is 1:(0.2~0.65).
Preferably, the composition includes, and 0.001~5wt% includes the first of indoles hydrochlorate to educate hair functional component；
0.01~10wt% includes that radix-polygoni multiflori extract, Herba Swertiae bimaculatae extract, ginseng extract, Herb Gynostemmae Pentaphylli extract and Radix Angelicae Sinensis extract
The second of object educates hair functional component；0.001~5wt% includes the antibacterial anti-inflammatory ingredient of licorice；The solvent is second
The water of alcohol 30wt% and surplus.
Preferably, the composition also includes selected from ethylene glycol, propylene glycol, butanediol, hexylene glycol, polyethylene glycol 200
~600, polypropylene glycol, binary alcohol esters, D-sorbite, trihydroxy tristearin, lavender oil, eucalyptus oil, citronella oil, Blumea oil, tea
Set the moisturizer of oil, peppermint oil, oil of grapefruit, rose oil, refined jasmine oil and rosemary oil；The moisturizer is in the combination
Weight ratio in object is 0.05~3wt%.
Preferably, the composition also includes selected from Phenoxyethanol, methylparaben, ethylparaben, nipalgin third
Ester, butyl hydroxybenzoate, isopropyl ester, isobutyl ester, base chloroisothiazole quinoline ketone, methylisothiazolinone, iodine propilolic alcohol butyl ammonia formic acid
The preservative of ester.
The present invention also provides a kind of preparation method for preparing hair follicle nutrient liquor composition described in above-mentioned any one,
First is added in the mixed liquor of second alcohol and water and educates hair functional component, is uniformly mixed, sequentially adds antibacterial anti-inflammatory ingredient and second
Hair functional component is educated, is uniformly mixed, adjusting pH value is 5~6.
The present invention also provides hair follicle nutrient liquor compositions described in above-mentioned any one in oil-control anticreep shampoo, anti-dandruff
Itch-stopping shampoo, nutritive active profit hair-cream, plant essence hair nourishing liquid, the application in hair follicle nutrition hair growth liquor class product.
Hair follicle nutrient liquor composition provided by the invention is curative for effect, can effectively facilitate hair growth, fast and safely, will not
Irritating negative effect is generated, the problematic patient of vast hair can be helped to release conscientiously worried.
Specific embodiment
The detailed description for preferred implementation method of the invention below of participating in the election of and including embodiment this public affairs can be more easily to understand
Open content.Term "comprising" used herein, " comprising ", " having ", " containing " or its any other deformation, it is intended that covering is non-
It is exclusive to include.For example, composition, step, method, product or device comprising listed elements are not necessarily limited to those and want
Element, but may include not expressly listed other elements or such composition, step, method, product or device it is intrinsic
Element.
Temperature, content or other values or parameter are excellent with range, preferred scope or a series of upper limit preferred values and lower limit
When the Range Representation that choosing value limits, this should be understood as specifically disclosing by any range limit or preferred value and any range
Any pairing of lower limit or preferred value is formed by all ranges, regardless of whether the range separately discloses.For example, when open
When range " 1~5 ", described range should be interpreted as including range " 1~4 ", " 1~3 ", " 1~2 ", " 1~2 and 4~
5 ", " 1~3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise the range is intended to include its end
Value and all integers and score in the range.
Term "comprising" used herein, " comprising ", " having ", " containing " or its any other deformation, it is intended that covering
Non-exclusionism includes.For example, composition, step, method, product or device comprising listed elements are not necessarily limited to those and want
Element, but may include not expressly listed other elements or such composition, step, method, product or device it is intrinsic
Element.
Now by referring to each illustrative embodiments of the invention, embodiment is hereinafter retouched in detail below
It states.Although will be of the invention in conjunction with illustrative embodiments description, it is to be understood that, this specification is not intended to limit the invention to
These illustrative embodiments.On the contrary, the present invention will not only cover these illustrative embodiments, also to cover by appended right
Various alternative forms, modification, equivalents and other embodiments in the spirit and scope of the present invention defined by it is required that.
The present invention provides a kind of hair follicle nutrient liquor compositions, on the basis of the total weight of the composition, the combination
Object includes:
0.001~5wt% includes the first of indoles hydrochlorate to educate hair functional component,
It include the second of Herba Swertiae bimaculatae extract to educate hair functional component with 0.01~10wt%,
And the solvent of surplus.
First educates hair functional component:
Described first educates the weight ratio of hair functional component in the composition preferably 0.001~2wt% in turn.
Of the present invention first educate hair ingredient include indoles hydrochlorate.The indoles hydrochlorate includes heteroauxin sodium, indoles
Sodium propionate, indolebutyric acid sodium, butyric acid potassium.Indoles hydrochlorate has auxin activity in the plant growth stage, can promote crop field
Crop, gourd, fruit and vegetable rooting of cuttings.
The described first indoles phosphate content educated in hair functional component is lower than 0.001wt% in total composition system,
It is not significant that hair effect is educated in promotion, if it exceeds 0.5wt%, then can reduce that the present invention second educates hair functional component educates hair effect,
And then preferably weight ratio 0.01~0.5wt% of the indoles hydrochlorate in composition of the present invention.
In addition, being preferably carried out mode as one kind of the present invention, the weight ratio of the licorice and indoles hydrochlorate is
1:(0.2~0.65), the composition under the ratio educates hair better effect.
Described first, which educates hair functional component, can also contain niacinamide, a kind of B family vitamin, the entitled pyridine -3- first of chemistry
Amide also known as niacinamide, in the living body with nicotinamide adenine dinucleotide and nicotinamide-adenine dinucleotide phosphate
Form exists, it can promote the effect of hair root cells peripheral vasodilation and nutrition supply.
Described first educate hair functional component can also containing 6- benzylaminopurine, pentadecanoic acid glyceride, minoxidil,
Carpronium chloride, t- flavanones, hinokitiol and nicotinic acid benzyl ester, cutin growth factor KGF.
Cutin growth factor KGF is a kind of basic protein growth factor of the subcutaneous histocyte secretion of human body, can be special
Stimulate the physiology courses such as the metabolism of epithelial cell, regeneration, differentiation and migration including cell etc..It is natural in human organism
The active soluble protein of existing one kind, is made of 194 amino acid encodings, and mature KGF has 163 amino acid residual
Base, N-terminal have a glycosylation site mainly to be secreted by subcutaneous tissue in human body, and specificity be integrated to epithelial cell table
The specific receptors in face start the gene expression that merisis is participated in epithelial cell by complicated signal transduction process, thus
Stimulate the metabolism of epithelial tissue.It can quickly be repaired for cuticula；With tender skin, improve skin quality and colour of skin effect；It is quick
The reparation of sense and red capillary.
Antibacterial anti-inflammatory ingredient:
Licorice,
Radix Glycyrrhizae system herbaceos perennial, plant is about 1~1.5 meter high, the tiny aobvious bottle green of blade, flower have yellow, it is blue,
Pansy, rhizome are tasted pleasantly sweet.Radix Glycyrrhizae is the Chinese herbal medicine of Chinese tradition, there is resolving sputum, moisturizing, anti-inflammatory, anti-filterability cause of disease
Body, anti-hepatotoxin and antibacterial and other effects.The main chemical compositions of Radix Glycyrrhizae are triterpenes and flavone compound, and there are also a small amount of biologies
Alkali, lignin, cumarin and a variety of amino acid.Flavones safety in licorice, especially Radix Glycyrrhizae, it is mild, can be effectively clear
Except oxygen radical.Also have and inhibits cytopathy, the function of protective tissue cell.
The licorice can choose commercially available, can also be prepared using following method: take net Radix Glycyrrhizae, be ground into
Coarse powder after being sufficiently humidified so as to weak aqua ammonia, is set in percolate pot, takes water as a solvent diacolation to after reddish brown, dilute sulfuric acid is slowly added into infiltration
It filters in liquid to no longer generating, filters, after precipitating is dissolved in a small amount of weak aqua ammonia, filtering, evaporation drying filtered fluid obtains Radix Glycyrrhizae extraction
Object.
The licorice includes dipotassium glycyrrhizinate, mono-ammonium glycyrrhizinate, glycyrrhizic acid powder, Carbenoxolone Sodium, glycyrrhizic acid one
Sylvite, glycyrrhizin, licoflavone, diammonium glycyrrhizinate, glycyrrhizic acid removal glycyrrhiza glucin.And then preferably dipotassium glycyrrhizinate, glycyrrhizic acid
Mono-ammonium.The licorice can choose commercially available acquisition.
Present inventor is during preparing the composition, unexpected discovery, plays antibacterial anti-inflammatory originally and makees
Licorice promotes the first performance for educating hair ingredient effect using can cooperate with together with indoles hydrochlorate, and obtains
Splendid, more preferably generating hair effect.Inventor speculate the possible reason is, licorice and indoles hydrochlorate use energy simultaneously
Enough on the basis of adjusting epidermis fat secretion, anti-inflammatory are antibacterial, inhibit the generation of dihydrotestosterone；Promote hair follicle to open, inhibit blood
Pipe is shunk, vasodilator smooth muscle allows first to educate hair effect component and preferably enter to promote the formation of ball top layer microcirculation
It inside epidermis and plays a role, increases the hair follicle nutrition of skin corium, and then improve epidermal keratinocyte and dermal fibroblast
Proliferation activity, promote hair growth.
The antibacterial anti-inflammatory ingredient can also include peony root extractive and ginger-root extract.
Peony root extractive,
It conventionally extracts moutan root bark and prepares.Moutan root bark is a kind of traditional Chinese medicine, the root bark of tree peony, that is, hair
The root skin of gelsemium section Chinese herbaceous peony platymiscium tree peony.The root bark of tree peony is bitterly, cool in nature, rich in the various bioactivators such as Paeonol, have heat-clearing,
Cool blood, analgesia and dispersing blood stasis and other effects.A large number of studies show that it is there are also anti-inflammatory, anti-aging and the effect of liver protection, there is good medicine
Reason activity.
The peony root extractive can be obtained by following preparation method: dry moutan root bark is immersed in commonly
Extract is prepared in Extraction solvent, is evaporated under reduced pressure or it can be by obtain it with extraction solution layering and.
Ginger-root extract,
Ginger is the fresh and tender stem of zingiber, belongs to perennial herb perennial plant.Ginger rhizome is full of nutrition, containing essence
Oil, gingerol, fat oil, resin, starch, pentosan, protein, cellulose, wax, pigment and trace quantity mineral substance element etc. are done
Content of material is 13.2%~15.5%, total lipid 5.7%~14.5%, total soluble sugar 2.02%~5.345%, cellulose
5.23~5.95%, crude protein 7.98%~10.04%, starch 5.78%~8.88%, 9.18~16.7mg/ of vitamin C
50, wherein content of starch is the abundantest, accounts for the 40%~60% of Jiang Ganchong.The more component of other contents then with the kind of ginger not
It is same and variant.Gingerol is one of principle active component in ginger.Containing the invasive wooden phenolic group structure in gingerol molecule, have its gingerol
There are very strong bioactivity and pharmacological action.Ginger-root extract can be used for treating trichophyte, chaff batch armful daughter bacteria, ringworm of the foot bacterium etc. and cause
Infection, there is special efficacy to seborrhagia disease and dandruff.
Specifically, the method for preparing ginger-root extract is to clean race removal impurity and mildew and rot part, cuts baking into pieces
It is dry, it crushes, then impregnated with organic solvent, is evaporated under reduced pressure, obtain ginger-root extract.Preferably, 70% second of race is selected
Alcohol extracting thing.
It is not particularly limited as the solvent for extracting said extracted object, can also enumerate water, methanol, ethyl alcohol, propyl alcohol, different
The ethers such as the polyalcohols such as the lower alcohols such as propyl alcohol, 1,3 butylene glycol, propylene glycol, dipropylene glycol, glycerol, ether, propyl ether, acetic acid are
The esters such as ester, butyl acetate, acetone, methyl ethyl ketone isopolarity organic solvent, physiological saline, phosphate buffer etc..
The weight ratio of the antibacterial anti-inflammatory ingredient in the composition is preferably 0.001~5%, and then preferably 0.01~
2wt%.
Second educates hair functional component:
Radix-polygoni multiflori extract,
The fleece-flower root is the dried root of polygonum multiflorum thunb first recorded in " Kaibao Bencao ".Also known as the tuber of multiflower knotweed, Goblin, He Xiang
Public affairs etc..To the record of the fleece-flower root in Compendium of Material Medica are as follows: " this object temperature, bitter and puckery flavor can blood-nourishing benefit liver, controlling nocturnal emission with astringent drugs kidney-nourishing, strong muscle
Bone, black hair on the temple, are tonic medicine." record RADIX POLYGONI MULTIFLORI PREPARATA in " Chinese Pharmacopoeia " version in 2010 there is nourishing liver and kidney, benefiting essence-blood, black beard and hair,
Strengthening the bones and muscles and other effects.It can be used for poliosis.All contain the fleece-flower root in many hair tonic, the compound Chinese medicinal preparation of black hair or products,
Since ancient times, the fleece-flower root and its processed product are all used for alopecia and the treatment of black hair, and the main chemical compositions in the fleece-flower root include
Anthraquinones, flavonoids, diphenylethylene, phospholipid etc..Wherein, quantitative finger of the Stibene-glucoside frequently as fleece-flower root quality standard
Mark.Stibene-glucoside is considered as the active constituent of black hair, has the function of promoting melanoma cells synthesis of melanin, molten
Effective molecular number of levodopa and TYR enzyme collision can be increased by the conception of change levodopa under liquid status.
Following methods acquisition can be used in the extract: according to fleece-flower root coarse powder and 60% ethyl alcohol with the ratio of 1:10,
Refluxing extraction 2~3 times, 2~3 hours every time, filtrate recycling ethanol obtained liquid extract；Add water dilute above-mentioned fleece-flower root liquid extract
Release, wherein water is 10 times of parts by weight of liquid extract, and dilution is enriched with through large pore resin absorption column, collected column liquid, water lotion with
And ethanol eluate, merge the above solution, solvent is recovered under reduced pressure, obtain concentrate, concentrate is dry to be extracted to get to the fleece-flower root
Object.
Herba Swertiae bimaculatae extract,
Swertia plant is the traditional medicine in China, is commonly called as " Swertia mussotii ", civil to be usually used in treating acute icteric liver
The diseases such as inflammation, cholecystitis, pneumonia, influenza, tonsillitis, osteomyelitis.And Herba Swertiae bimaculatae extract is widely used in treatment abdomen in Japan
Portion's pain, skin insect infection and flu.Swertia patens Zhong Kou mountain ketone and its glycoside, iridoid and its glycosides compound are main
Active constituent, usually contain in Herba Swertiae bimaculatae extract 2~4% Swertiamarin, Swertianolin, erthrocentaurin, work as medicine
Alcohol, caryophyllin and erythricine.Herba Swertiae bimaculatae extract can improve skin as the Chinese blister beetle and capsicum tincture that derive from animal and plant
Temperature simultaneously promotes hair growth, and cholinomimetic energy drug, which improves the physiologic effect of skin temperature or vasodilator effect, can stimulate dimension
Hold the blood flow of skin function.So Herba Swertiae bimaculatae extract can be used as blood circulation accelerant, and then stimulate the life of hair
It is long.Swertia patens and indoles hydrochlorate are used cooperatively by the present invention, and beneficial effect is significant.
The Swertia patens can be Swertia yunnanensis, Herba Swertiae bimaculatae, Swertia kauitchensis Franch, northern Swertia patens, embrace stem river deer tooth
Dish, Japanese Swertia patens.The Herba Swertiae bimaculatae extract can choose commercially available.
Ginseng extract,
Ginseng is mild-natured, sweet in flavor, slight bitter, tepor.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.With " it reinforces vital energy, reinforces the spleen to benefit the lung, benefit of calming the nerves
The effect of intelligence "." the disease mesh that correction of the errors of medical works TONGQIAOHUOXUE Decoction is controlled " says that " epilation, each medical book all say blood trouble, do not know skin clearly
In the outer blood stasis of meat, block blood network, new blood is unable to hair care, therefore falling out." taste be qi and blood metaplasia source, source scarcity then sends out mistake
It supports and falls off；Heart governing blood and vessels, if blood deficiency arteries and veins not general rule hair also become homeless it is feeding." lung person, Hua Mao are led in skin.If " lung
Surname dissipate defends airway dysfunction decrease, then fur is without being made moist, and dry skin, hair is withered to fall off.Studies have shown that ginseng extract is in hair
Hair follicle can be promoted to enter growth period from stand-down in capsule nutrient solution, and the growth of hair can be accelerated in early stage in growth period, because
This, ginseng is not only tonic invigorator, and has good hair tonic and hair care effect.
Ginseng extract of the present invention is 75% ethanol extract of ginseng.
Ginseng extract of the present invention can choose commercially available, can also be prepared using following method: with 75% second
Alcohol is that extracting solution extracts ginseng coarse powder, circumfluence distillation 2h.It is filtered after reflux, after filtrate decompression refluxing ethanol to no alcohol taste,
Add equivalent ether defatting, divide aqueous, add extracting n-butyl alcohol 2 times, merge butanol extraction liquid, is concentrated under reduced pressure and recycles positive fourth
Alcohol, concentrate are dried under reduced pressure, and obtain ginseng extract.
Herb Gynostemmae Pentaphylli extract,
Herb Gynostemmae Pentaphylli extract is to isolate more than 50 gynosaponins and panaxoside one from this plant of gynostemma pentaphylla
Sample belongs to tetracyclic triterpenes Ma saponin, wherein gynosaponin III, IV, VII, Ⅻ respectively with sanchinoside E1, Rb3, Rd,
F2 is same substance, and gynosaponin member V-AH is identical as Ginsenoside Rg3, and gynosaponin I decomposes to obtain ginseng soap by enzyme
Glucoside K.Pharmacology and clinic decompose to obtain panaxoside K.Traditional Chinese medicine thinks, gynostemma pentaphylla bitter, cold in nature, has clearing heat and detoxicating, tonifying Qi, only
Cough, the function of eliminating the phlegm.Extracting method: 10 times of 75% ethyl alcohol of amount impregnate 12 hours, and ultrasonic extraction 3 times, each 80min.
Angelica extract,
Umbelliferous dry root, perennial herb, complete stool have special fragrance.Main root tubbiness, loose meat are divided into more below
The thick long supporting root of number.Stem is upright, band purple.Perennial herb is 0.4-1 meter high.Stem uprightly with purple, there is obvious longitudinal grin straight trough,
Glabrous.About 10-25 centimetres of dry root overall length, 3-10 centimetres of height, appearance grayish brown or brownish brown, the vertical wrinkle of entirety tool
Line, angelica body is slightly cylindrical, body and it is uneven, it is lower to have 3-5 or more angelica tails.Active constituent containing Ligustilide,
N-butene acyl lactone, ferulic acid, niacin, sucrose and a variety of amino acid and sesquiterpenoids etc..Its cosmetology effect
Capillary of skin can be expanded from Radix Angelicae Sinensis, accelerates blood circulation.Radix Angelicae Sinensis contains microelement abundant, and energy skin nutrition prevents
It is coarse.It can be used for acne, foxiness, freckle and alopecia.
All kinds of extracts can also be the bulk pharmaceutical chemicals such as the fleece-flower root, Swertia patens, ginseng are ground into a powder it is uniformly mixed, then
It is carried out using water extraction and alcohol precipitation method, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation
It is refining to obtain extract.
Of the present invention second, which educates hair functional component, can choose radix-polygoni multiflori extract, Herba Swertiae bimaculatae extract, ginseng extraction
The combination of any one or more of object, Herb Gynostemmae Pentaphylli extract and angelica extract can play master in the compositions of the present invention
That wants educates hair function.
In a present invention preferably specific embodiment, described second educates the weight of hair functional component in the composition
Amount is than being 0.05~5wt%.
Solvent:
The solvent preferred alcohol aqueous solution.
As etoh solvent, dehydrated alcohol and 95 volume % ethyl alcohol can be enumerated.Microcirculation etc. is improved to scalp
From the point of view of, the combined amount of ethyl alcohol is 20wt% or more, more preferable 25wt% or more preferably with respect to total composition.From to sensitive flesh
From the point of view of the people of skin does not bring stimulation aspect, preferably 45wt% is hereinafter, preferred 30wt% in turn.
As aqueous solvent, relative to total composition, the amount of aqueous solvent is surplus.By being set as in above range,
The cooperative effect of composition each component can preferably be played.
Other compositions:
Hair follicle nutrient solution of the present invention other than comprising above-mentioned main component, can also include it is conventional pharmaceutically can be with
The substance of receiving uses no any specific limitation as long as these components do not have safety problem.In addition, their effect
Mechanism does not have any problems.However, these ingredients are used as commercial hair growth stimulant to play arterial dilation and activate
When hair follicle cell, they can be prepared in accordance with known methods using commercially available raw material.
As such ingredient, nonionic surfactant, Semi-polar surfactants, both sexes table can be arbitrarily added
It is polyalcohols, organic salt, moisturizer other than face activating agent, anionic polymer, nonionic polymeric, d ingredient, whole
Send out the fungicide, fat such as antioxidants, triclosan, the triclocarbans such as agent, solvable agent, dibutyl hydroxy toluene or alpha-tocopherol
The viscosity modifiers such as sour single ethanol amide, fatty diglycollic amide, ultraviolet absorbing agent, antioxidant, protein derivatives,
The anti-inflammatory agents, styrax such as the anti-dandruff agents such as animals and plants extracting solution, piroctone olamine salt, zinc pyrithione, enoxolone dipotassium
The pH adjusting agents, vitamin E vinegar such as preservatives, citric acid, the triethanolamine such as acid and its salt, parabens, Kathon CG
The pearling agents such as acid esters antioxidant, di-fatty acid esters, opacifiers, hydrotropic agent, vitamins, volatile oil,
Hydrophobic solvent, dilution property solvent and pigment, fragrance etc..
Specifically, moisturizer can be one or more selected from ethylene glycol, propylene glycol, butanediol, hexylene glycol, polyethylene glycol
(PEG) carboxylate, the mountain of 200-600, polypropylene glycol (PPG), binary alcohol esters and ether, the Arrcostab of PEG or PPG, PEG or PPG
The compound of pears sugar alcohol, trihydroxy tristearin and polyol derivative.Or it can choose lavender oil, eucalyptus oil, citronella oil, Chinese mugwort
The plants quintessence such as leaf oil, tea oil, peppermint oil, oil of grapefruit, rose oil, refined jasmine oil, rosemary oil, loquat-leaf extract
Oil.Content of humectant preferably 0.05~3wt% in hair follicle nutrient liquor composition.If containing in hair follicle nutrient liquor composition
Amount is lower than 0.05wt%, then cannot obtain sufficient moistening effect, if it exceeds 3wt%, then the property of hair follicle nutrient liquor composition
Matter may change.It is further preferred that the content of moisturizer is 0.2~2wt%.
Specifically, pH adjusting agent makes hair follicle nutrient liquor composition pH value of the invention be close with skin, for example can make
With alkali metal hydroxides such as citric acid, potassium hydroxide, sodium hydroxides, pH value is preferably adjusted to 5~6.
Specifically, preservative can be added in hair follicle nutrient liquor composition of the present invention to protect product, is allowed to from micro-
Biological pollution.It can choose Phenoxyethanol, parabens (including methylparaben, ethyl ester, propyl ester, butyl ester, isopropyl ester and different
Butyl ester etc.), Form aldehyde release body preservative, methylchloroisothiazandnone and methylisothiazolinone mixture, methyl-isothiazol
The combination of one or more of quinoline ketone, iodine propilolic alcohol butyl mephenesin Carbamate.
As the hair follicle nutrient liquor composition of emulsion agent, creme or gel preparations, increasing can be added into above-mentioned composition
Thick dose or other forming agents, such as: the ingredients such as oil components, emulsifier and/or thickener, according to existing method system
It is standby.Wherein oil components such as stearic acid, stearyl alcohol or lanolin etc.；Emulsifier, such as: octyldodecanol or polyoxy second whale
Cerul ether etc..The advantages of such hair follicle nutrient liquor composition is preferably to stop effect because having, and can solve medical fluid and used
The raw waste of loss of production is drained in journey.Paste, the slow releasing function of gelling agent are also beneficial to the further absorption of medical fluid simultaneously.
Various dosage forms can be made for external application as hair follicle nutrient liquor composition of the invention is filled, can be liquid shape
Washing lotion, spray, dew liquid etc. or semi-solid form can be specifically made in formula, such as solution, as paste, gelling agent, creme,
Emulsion, patch, wet tissue etc..It can be succinct with oil-control anticreep shampoo, anti-dandruff and itching-relieving shampoo, nutritive active profit hair-cream, plant
The form external application of hair nourishing liquid, hair follicle nutrition hair growth liquor etc..Hair follicle nutrient liquor composition of the invention can be with above-mentioned essential component
It is obtained according to conventional methods with any ingredient mixing.
The preparation method of hair follicle nutrient liquor composition of the present invention can use common hair nourishing liquid preparation method.
Specifically, it may is that the selection starting components are uniformly mixed according to parts by weight, preferably in second alcohol and water
Mixed liquor in be added and first educate hair functional component, be uniformly mixed, sequentially add antibacterial anti-inflammatory ingredient and second and educate hair ingredient,
Adjusting pH value again is 5~6, and then preferably 5.5~6.
Preferably embodiment, hair follicle nutrient liquor composition is on the basis of the total weight of the composition, and described group
Closing object includes: 0.01~0.5wt% indoles hydrochlorate, 0.05~5wt% second educate hair functional component, 30wt% ethyl alcohol, surplus
Water.
Preferably embodiment, hair follicle nutrient liquor composition is on the basis of the total weight of the composition, and described group
Closing object includes: 0.3~1wt% radix-polygoni multiflori extract, 0.5~1.5wt% Herba Swertiae bimaculatae extract, 0.2~0.5wt% ginseng mention
Take object, 0.2~1wt% dipotassium glycyrrhizinate, 0.05~0.5wt% heteroauxin sodium, 0.2~0.4wt% butanediol, 0.3~
0.6wt% eucalyptus oil, 0.02~0.03wt% Buddhist nun's platinum methyl esters, 30~45wt% ethyl alcohol, excess water.
Preferably embodiment, hair follicle nutrient liquor composition is on the basis of the total weight of the composition, and described group
Closing object includes: 0.3wt% radix-polygoni multiflori extract, 0.7wt% Herba Swertiae bimaculatae extract, 0.2wt% ginseng extract, 0.5wt%
Dipotassium glycyrrhizinate, 0.3wt% heteroauxin sodium, 0.3wt% butanediol, 0.5wt% eucalyptus oil, 0.02wt% Buddhist nun's platinum methyl esters,
30wt% ethyl alcohol, excess water.
Preferably embodiment, hair follicle nutrient liquor composition is on the basis of the total weight of the composition, and described group
Closing object includes: 0.3~1wt% radix-polygoni multiflori extract, 0.5~1.5wt% Herba Swertiae bimaculatae extract, 0.2~0.5wt% ginseng mention
Take object, 0.2~0.5wt% Herb Gynostemmae Pentaphylli extract, 0.2~0.5wt% angelica extract, 0.5~1.5wt% dipotassium glycyrrhizinate,
0.1~0.6wt% peony root extractive, 0.2~0.4wt% ginger-root extract, 0.2~0.4wt% butyric acid potassium, 0.1~
0.2wt% niacinamide, 0.3~0.5wt% butanediol, 0.3~0.6wt% eucalyptus oil, 0.02~0.03wt% Buddhist nun's platinum methyl esters,
30~40wt% ethyl alcohol, excess water.
Preferably embodiment, hair follicle nutrient liquor composition is on the basis of the total weight of the composition, and described group
Closing object includes: 0.3wt% radix-polygoni multiflori extract, 0.7wt% Herba Swertiae bimaculatae extract, 0.2wt% ginseng extract, 1wt% are sweet
Oxalic acid dipotassium, 0.2wt% peony root extractive, 0.3wt% ginger-root extract, 0.3wt% butyric acid potassium, 0.1wt% nicotinoyl
Amine, 0.3wt% butanediol, 0.5wt% eucalyptus oil, 0.02wt% Buddhist nun's platinum methyl esters, 30wt% ethyl alcohol, excess water.
Preferably embodiment, hair follicle nutrient liquor composition is on the basis of the total weight of the composition, and described group
Closing object includes: 0.3wt% radix-polygoni multiflori extract, 0.7wt% Herba Swertiae bimaculatae extract, 0.2wt% ginseng extract, 0.2wt%
Herb Gynostemmae Pentaphylli extract, 0.2wt% angelica extract, 1wt% dipotassium glycyrrhizinate, 0.2wt% peony root extractive, 0.3wt% ginger
Root extract, 0.3wt% butyric acid potassium, 0.1wt% niacinamide, 0.3wt% butanediol, 0.5wt% eucalyptus oil, 0.02wt%
Buddhist nun's platinum methyl esters, 30wt% ethyl alcohol, excess water.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following embodiment is only used
In the invention will be further described, it should not be understood as limiting the scope of the invention, professional and technical personnel in the field
The some nonessential modifications and adaptations made according to the content of aforementioned present invention, still fall within protection scope of the present invention.In addition,
If the raw material being related to below is all commercially available without other explanations.
[Examples 1 to 10, comparative example 1~5]
The composition of the embodiment and comparative example is prepared according to preparation method provided by the invention, that is, prepares all kinds of raw materials
And extract, it weighs by weight spare；First is added in the mixed liquor of second alcohol and water and educates hair functional component, is uniformly mixed,
It sequentially adds antibacterial anti-inflammatory ingredient and second and educates hair ingredient, be selectively supplemented that aqueous solvent is added according to total weight, adjust pH
Value is 5.5~6.
Raw material:
A1 radix-polygoni multiflori extract, according to fleece-flower root coarse powder and 60% ethyl alcohol with the ratio of 1:10, refluxing extraction 2 times, often
Secondary 3 hours, filtrate recycling ethanol obtained liquid extract；Above-mentioned fleece-flower root liquid extract is diluted with water, wherein water is the 10 of liquid extract
Times parts by weight, dilution are enriched with through large pore resin absorption column, collect column liquid, water lotion and ethanol eluate, more than merging
Solvent is recovered under reduced pressure in solution, obtains concentrate, and concentrate is dried to arrive radix-polygoni multiflori extract.
A2 Herba Swertiae bimaculatae extract, the Swertia kauitchensis Franch extract purchased from Xi'an Bioisystech Co., Ltd, Tianrui.
A3 ginseng extract is that extracting solution extracts ginseng coarse powder, circumfluence distillation 2h with 75% ethyl alcohol.It is filtered after reflux,
After filtrate decompression refluxing ethanol to no alcohol taste, add equivalent ether defatting, divide aqueous, add extracting n-butyl alcohol 2 times, merges just
Recycling n-butanol is concentrated under reduced pressure in butanol, before immunoassay liquid, and concentrate is dried under reduced pressure, and obtains ginseng extract.
A4 Herb Gynostemmae Pentaphylli extract, 10 times of 75% ethyl alcohol of amount impregnate 12 hours, and ultrasonic extraction 3 times, each 80min obtains strand
Blue extract.
A5 angelica extract is purchased from Xi'an Chang Yue plant Chemical Co., Ltd..
B1 mono-ammonium glycyrrhizinate is purchased from Jiangsu Tiansheng Pharmaceutical Co., Ltd..
B2 dipotassium glycyrrhizinate is purchased from Jiangsu Tiansheng Pharmaceutical Co., Ltd..
The moutan root bark fragment of clean dry is immersed in 95% alcohol solvent by B3 peony root extractive, 40 DEG C of constant temperature
Water-bath mechanical shaking extraction 5h, centrifugation 20min obtain peony root extractive.
B4 ginger-root extract cleans race removal impurity and mildew and rot part, cuts drying into pieces, crushing, then with 70% second
Alcoholic solvent is impregnated, and vacuum distillation obtains ginger-root extract.
C1 heteroauxin sodium is purchased from Shanghai Yuan Ye Bioisystech Co., Ltd.
C2 butyric acid potassium is purchased from Shanghai Yuan Ye Bioisystech Co., Ltd.
C3 niacinamide is purchased from Switzerland Lonza.
Each component ratio of specific embodiment and comparative example is shown in Table 1, and composition total weight shown in table is 100 parts.
Evaluation method:
1, influence of the hair follicle nutrient liquor composition more of the present invention to mouse neonatal hair growth.
Experimental subjects: choosing KM mouse 75,18~22g of weight of SPF rank, half male and half female, then every 5 one group of works
For embodiment or the experimental subjects of comparative example.Back of mice hair is rejected to smooth, no wound without residual hair, the area 3 that loses hair or feathers ×
4cm2, the nutrient liquor composition of the embodiment and comparative example is applied to mouse hair removal section, the daily upper and lower noon respectively smears 1 time,
The continuous nutrient solution dosage 30 days, smeared every time is 0.3ml/ every.
(1) it scores the growth conditions of the new piliation of mouse hair removal section, standard are as follows:
0 point: absent hair growth；
1 point: shallow staple length expires hair removal section；
2 points: the half of newborn staple length and density about non-hair removal section；
3 points: newborn staple length and non-hair removal section indifference；The mouse for irregular hair growth occur is calculated by area ratio.
Calculate the mean scores of every group of mouse state.
(2) newborn staple length measurement:
On skin after the punching of every mouse hair removal section, most become mildewed 10 with magnifying glass and tweezers selection, vernier caliper measurement
Length, using the average length of 10 hairs as the newborn staple length of every mouse.
2, whether evaluation nutrient solution is irritating to skin.
25~50 years old 150 hair sparse hair loss patients, are randomly divided into 15 groups, the experiment as embodiment or comparative example
Object.To use the state of towel after hair washing, nutrient solution described in 2.0ml embodiment or comparative example is applied to hair, is commented
Whether there is or not excitement, following commentary valence benchmark evaluations after valence is smeared, and calculate average value.
5 points: absolutely not experiencing stimulation；
4 points: not experiencing stimulation；
3 points: almost without stimulation is experienced；
2 points: experiencing stimulation；
1 point: experiencing stimulation strongly.
Evaluation result is shown in Table 2.
Table 1
Table 2
It can be seen that hair follicle nutrient liquor composition of the present invention can dramatically increase mouse depilation from above-described embodiment and comparative example
The quantity and length of the new piliation in area improve hair growth situation, and safe and non-stimulating, to obtain the technology of the present invention effect
Fruit.Example above-mentioned is merely illustrative, for explaining some features of the disclosure.The attached claims are intended to requirement can be with
The range as wide as possible imagined, and embodiments as presented herein is only the combined selection according to all possible embodiment
Embodiment explanation.Therefore, the purpose of applicant is the example that the attached claims are not illustrated feature of the invention
Selectional restriction.And the progress in science and technology by formed language express it is inaccurate due to and be not presently considered
Possible equivalent or son replacement, and these variations should also be interpreted to be covered by the attached claims in the conceived case
Lid.
Claims (9)
1. hair follicle nutrient liquor composition, on the basis of the total weight of the composition, the composition includes:
0.001~5wt% includes the first of indoles hydrochlorate to educate hair functional component；
0.01~10wt% includes radix-polygoni multiflori extract, Herba Swertiae bimaculatae extract, ginseng extract strand, Herb Gynostemmae Pentaphylli extract and works as
The second of extract is returned to educate hair functional component；
0.001~5wt% includes the antibacterial anti-inflammatory ingredient of licorice；
Solvent is the mixed liquor of second alcohol and water.
2. hair follicle nutrient liquor composition according to claim 1, which is characterized in that the licorice includes glycyrrhizic acid
Dipotassium, mono-ammonium glycyrrhizinate, Carbenoxolone Sodium, one sylvite of glycyrrhizic acid, glycyrrhizin, licoflavone, diammonium glycyrrhizinate；
The antibacterial anti-inflammatory ingredient also includes peony root extractive and ginger-root extract.
3. hair follicle nutrient liquor composition according to claim 1, which is characterized in that the indoles hydrochlorate includes heteroauxin
Sodium, indolepopionic acid sodium, indolebutyric acid sodium, butyric acid potassium.
4. hair follicle nutrient liquor composition according to claim 1, which is characterized in that described first, which educates hair functional component, also wraps
Niacinamide-containing, 6- benzylaminopurine, pentadecanoic acid glyceride, minoxidil, carpronium chloride, t- flavanones, 4- isopropyl basic ring
Heptadiene phenolic ketone, nicotinic acid benzyl ester and cutin growth factor KGF.
5. hair follicle nutrient liquor composition according to claim 1, which is characterized in that the licorice and indoles hydrochlorate
Weight ratio be 1:(0.2~0.65).
6. hair follicle nutrient liquor composition according to claim 1, which is characterized in that the composition also includes selected from second
Glycol, propylene glycol, butanediol, hexylene glycol, polyethylene glycol 200~600, polypropylene glycol, binary alcohol esters, D-sorbite, trihydroxy
Tristearin, lavender oil, eucalyptus oil, citronella oil, Blumea oil, tea oil, peppermint oil, oil of grapefruit, rose oil, refined jasmine oil and
The moisturizer of rosemary oil；The weight ratio of the moisturizer in the composition is 0.05~3wt%.
7. hair follicle nutrient liquor composition according to claim 1, which is characterized in that the composition also includes selected from benzene
Oxyethanol, methylparaben, ethylparaben, propylben, butyl hydroxybenzoate, isopropyl ester, isobutyl ester, base chloroisothiazole quinoline
Ketone, methylisothiazolinone, iodine propilolic alcohol butyl mephenesin Carbamate preservative.
8. a kind of preparation method for preparing hair follicle nutrient liquor composition described in any one of claim 1~7, feature exist
In, first is added in a solvent and educates hair functional component, it is uniformly mixed, it sequentially adds antibacterial anti-inflammatory ingredient and second and educates hair effect
Ingredient is uniformly mixed, and adjusting pH value is 5~6.
9. hair follicle nutrient liquor composition described in any one of claim 1~7 is washed in oil-control anticreep shampoo, anti-dandruff and itching-relieving
It becomes visible, the application in nutritive active profit hair-cream, plant essence hair nourishing liquid, hair follicle nutrition hair growth liquor class product.
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| CN107789211A (en) * | 2017-08-01 | 2018-03-13 | 芜湖华海生物科技股份有限公司 | Phenoxyethanol base preservative and its preparation method and application |
| CN107789210A (en) * | 2017-08-01 | 2018-03-13 | 芜湖华海生物科技股份有限公司 | A kind of cosmetics preservative and its preparation method and application |
| CN107913190A (en) * | 2017-08-01 | 2018-04-17 | 芜湖华海生物科技股份有限公司 | Cosmetics preservative based on nipagin esters and its preparation method and application |
| CN110721125A (en) * | 2018-07-16 | 2020-01-24 | 上海绘妍匠心化妆品有限公司 | Raw material composition for promoting human keratinocyte proliferation and application thereof |
| CN111437299A (en) * | 2020-06-01 | 2020-07-24 | 上海希尔维生物科技有限公司 | Gynostemma pentaphylla plant extract solution and application thereof in preparing medicine for promoting hair growth |
| CN112263520B (en) * | 2020-10-30 | 2022-08-12 | 花安堂生物科技集团有限公司 | Hair-blacking composition, hair-blacking essence and application of hair-blacking essence |
| CN112369603A (en) * | 2020-11-16 | 2021-02-19 | 浙江九旭药业有限公司 | Nanoemulsion nutrient solution for preventing hair loss, growing hair and strengthening hairy roots and preparation method and application thereof |
| CN113576301A (en) * | 2021-08-23 | 2021-11-02 | 菏泽牡丹纸业有限公司 | Preparation process of peony root extract essential oil wet tissue |
| CN114053190B (en) * | 2021-12-29 | 2023-07-11 | 威莱(广州)日用品有限公司 | Anti-drop essence and preparation method thereof |
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| JPH0873325A (en) * | 1994-09-06 | 1996-03-19 | Kao Corp | Hair-tonic and hair-growing agent |
| CN101516320A (en) * | 2006-08-25 | 2009-08-26 | 株式会社泰熊Eco生命科学 | Uses of rare earth elements for hair improvement |
| CN104602763A (en) * | 2012-03-21 | 2015-05-06 | 宾夕法尼亚大学理事会 | Compositions and methods for regulating hair growth |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873325A (en) * | 1994-09-06 | 1996-03-19 | Kao Corp | Hair-tonic and hair-growing agent |
| CN101516320A (en) * | 2006-08-25 | 2009-08-26 | 株式会社泰熊Eco生命科学 | Uses of rare earth elements for hair improvement |
| CN104602763A (en) * | 2012-03-21 | 2015-05-06 | 宾夕法尼亚大学理事会 | Compositions and methods for regulating hair growth |
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