CN107913190A - Cosmetics preservative based on nipagin esters and its preparation method and application - Google Patents
Cosmetics preservative based on nipagin esters and its preparation method and application Download PDFInfo
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- CN107913190A CN107913190A CN201710644774.1A CN201710644774A CN107913190A CN 107913190 A CN107913190 A CN 107913190A CN 201710644774 A CN201710644774 A CN 201710644774A CN 107913190 A CN107913190 A CN 107913190A
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- Prior art keywords
- phenoxyethanol
- solvent
- nipagin esters
- cosmetics
- ethylparaben
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of cosmetics preservative based on nipagin esters and its preparation method and application, is somebody's turn to do the cosmetics preservative based on nipagin esters and is made of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent；Wherein, the weight ratio of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent is 35 45：25‑33：20‑30：50‑60.The cosmetics preservative based on nipagin esters has excellent antibacterial effect and to skin gently so that it can be competent at skin care item antiseptic, while the preparation method raw material is easy to get, process is simple, easy to implement.
Description
Technical field
The present invention relates to preservative, and in particular, to a kind of based on the cosmetics preservative of nipagin esters and its preparation side
Method and application.
Background technology
Skin care item, are both the skin-protection product for protecting skin.With social economy continuous progress and material life it is abundant,
Skin care item, are no longer there was only the thing risen of the rich just in the past.Nowadays skin care item have come into ordinary citizen house as the popular vehicles.It gives people
Spirit, image enhancing play the role of it is great.Skin care item species is various, and feature is different.By function graduation point, skin care item
There are the skin care item such as moisturizing, whitening, moisturizing, oil-control, anti-aging, sensitive skin, pore refining, blackhead of dispelling, nti-freckle, the fat that disappears.
Either which kind of skin care item is not that can once or twice use, and generally requires the storage long period,
It certainly will need to consider anti-corrosion effect in storing process, although existing preservative can have certain anti-corrosion effect, for
Skin has certain stimulation.
The content of the invention
, should the object of the present invention is to provide a kind of cosmetics preservative based on nipagin esters and its preparation method and application
Cosmetics preservative based on nipagin esters has excellent antibacterial effect and to skin gently so that it can be competent at shield
Skin product antiseptic, while the preparation method has process simple and raw material is easy to get effect.
To achieve these goals, the present invention provides a kind of cosmetics preservative based on nipagin esters, Buddhist nun should be based on
The cosmetics preservative of the golden ester of pool is made of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent；Wherein, Phenoxyethanol,
The weight ratio of methyl hydroxybenzoate, ethylparaben and solvent is 35-45：25-33：20-30：50-60.
Present invention also offers a kind of preparation method of the cosmetics preservative based on nipagin esters, which includes：
1）Phenoxyethanol is dissolved in solvent so that Phenoxyethanol solution is made；
2）By methyl hydroxybenzoate, ethylparaben added to Phenoxyethanol solution with the obtained cosmetics anti-corrosion based on nipagin esters
Agent；
Wherein, the weight ratio of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent is 35-45：25-33：20-30：50-
60。
Invention further provides a kind of above-mentioned answering in cosmetics based on the cosmetics preservative of nipagin esters
With.
In above-mentioned technical proposal, the present invention has excellent resist by the obtained preservative of synergistic effect of each component
Bacterium effect and gentle to skin so that it can be competent at skin care item antiseptic, at the same the preparation method have process simply and
Raw material is easy to get effect.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Embodiment
The embodiment of the present invention is described in detail below.It is it should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
, should the cosmetics anti-corrosion based on nipagin esters the present invention provides a kind of cosmetics preservative based on nipagin esters
Agent is made of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent；Wherein, Phenoxyethanol, methyl hydroxybenzoate, nipalgin
The weight ratio of ethyl ester and solvent is 35-45：25-33：20-30：50-60.
In the above-mentioned cosmetics preservative based on nipagin esters, each component content can select in wide scope, but
It is to make obtained preservative that there is excellent antibacterial effect, it is preferable that Phenoxyethanol, methyl hydroxybenzoate, ethylparaben
Weight ratio with solvent is 38-42：28-30：25-28：55-58.
In the above-mentioned cosmetics preservative based on nipagin esters, the specific species of solvent can be selected in wide scope
Select, but in order to make obtained preservative that there is excellent antibacterial effect, it is preferable that solvent is propane diols and/or 1,3- fourth two
Alcohol.
Present invention also offers a kind of preparation method of the cosmetics preservative based on nipagin esters, which includes：
1）Phenoxyethanol is dissolved in solvent so that Phenoxyethanol solution is made；
2）By methyl hydroxybenzoate, ethylparaben added to Phenoxyethanol solution with the obtained cosmetics anti-corrosion based on nipagin esters
Agent；
Wherein, the weight ratio of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent is 35-45：25-33：20-30：50-
60。
In above-mentioned preparation method, each component content can select in wide scope, but in order to make obtained anti-corrosion
Agent has excellent antibacterial effect, it is preferable that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 38-
42：28-30：25-28：55-58.
In above-mentioned preparation method, the specific species of solvent can select in wide scope, but obtained in order to make
Preservative has excellent antibacterial effect, it is preferable that solvent is propane diols and/or 1,3-BDO.
In the step 1 of above-mentioned preparation method）In, the concrete mode and condition of mixing can select in wide scope,
But in order to make obtained preservative that there is excellent antibacterial effect, it is preferable that in step 1）In, Phenoxyethanol passes through with solvent
The mode of stirring is mixed, and stir speed (S.S.) is 2000-3000rpm, mixing time 3-5h.
In the step 2 of above-mentioned preparation method）In, the concrete mode and condition of mixing can select in wide scope,
But in order to make obtained preservative that there is excellent antibacterial effect, it is preferable that in step 2）In, nipagin esters are shaken by ultrasound
The mode swung is dissolved in Phenoxyethanol solution, and ultrasonic vibration meets the following conditions：Supersonic frequency is 60-80KHz, during concussion
Between be 1-2h.
In the step 2 of above-mentioned preparation method）In, the feeding sequence of nipagin esters can select in wide scope, still
In order to make obtained preservative that there is excellent antibacterial effect, it is preferable that in step 2）In, nipagin esters pass through ultrasonic vibration
Mode is dissolved in Phenoxyethanol solution, it is preferable that the feeding sequence of nipagin esters is followed successively by methyl hydroxybenzoate, ethylparaben.
Invention further provides a kind of above-mentioned answering in cosmetics based on the cosmetics preservative of nipagin esters
With.
The present invention will be described in detail by way of examples below.
Embodiment 1
1）Phenoxyethanol is passed through into stirring（Stir speed (S.S.) is 2000rpm, mixing time 3h）It is dissolved in solvent（Propane diols）With system
Obtain Phenoxyethanol solution；
2）Methyl hydroxybenzoate, ethylparaben are added to Phenoxyethanol solution successively, and carry out ultrasonic vibration（Supersonic frequency
For 60KHz, the concussion time is 1h）The cosmetics preservative A1 based on nipagin esters is made；Wherein, Phenoxyethanol, nipalgin
The weight ratio of methyl esters, ethylparaben and solvent is 35：25：20：50.
Embodiment 2
1）Phenoxyethanol is passed through into stirring（Stir speed (S.S.) is 3000rpm, mixing time 5h）It is dissolved in solvent（1,3 butylene glycol）
Phenoxyethanol solution is made；
2）Methyl hydroxybenzoate, ethylparaben are added to Phenoxyethanol solution successively, and carry out ultrasonic vibration（Supersonic frequency
For 60-80KHz, the concussion time is 1-2h）The cosmetics preservative A2 based on nipagin esters is made；Wherein, Phenoxyethanol, Buddhist nun
The weight ratio for mooring tortoise beetle ester, ethylparaben and solvent is 45：33：30：60.
Embodiment 3
The cosmetics preservative A3 based on nipagin esters is made in method according to embodiment 1, the difference is that benzene oxygen second
Alcohol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 40：29：26：57.
Embodiment 4
The cosmetics preservative A4 based on nipagin esters is made in method according to embodiment 1, the difference is that benzene oxygen second
Alcohol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 38：28：25：55.
Embodiment 5
The cosmetics preservative A5 based on nipagin esters is made in method according to embodiment 1, the difference is that benzene oxygen second
Alcohol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 42：30：28：58.
Embodiment 6
The cosmetics preservative A6 based on nipagin esters is made in method according to embodiment 1, the difference is that step 2）
In, the feeding sequence of nipagin esters is that methyl hydroxybenzoate, ethylparaben are carried out at the same time dispensing.
Comparative example 1
The cosmetics preservative B1 based on nipagin esters is made according to the method for embodiment 1 according to embodiment, it is different
It is that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 30：30：25：55.
Comparative example 2
The cosmetics preservative B2 based on nipagin esters is made according to the method for embodiment 1 according to embodiment, it is different
It is that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 50：30：25：55.
Comparative example 3
The cosmetics preservative B3 based on nipagin esters is made according to the method for embodiment 1 according to embodiment, it is different
It is that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 40：20：25：55.
Comparative example 4
The cosmetics preservative B4 based on nipagin esters is made according to the method for embodiment 1 according to embodiment, it is different
It is that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 40：35：25：55.
Comparative example 5
The cosmetics preservative B5 based on nipagin esters is made according to the method for embodiment 1 according to embodiment, it is different
It is that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 40：28：15：55.
Comparative example 6
The cosmetics preservative B6 based on nipagin esters is made according to the method for embodiment 1 according to embodiment, it is different
It is that Phenoxyethanol, methyl hydroxybenzoate, the weight ratio of ethylparaben and solvent are 40：28：35：55.
Detect example 1
Above-mentioned bacteriostatic agent is added in vaseline and beeswax lipstick is made, then detect its performance by the following method, wherein,
Biocidal property parameter is by defending method prison hair [2002] the 229th《Disinfection technology standard》（Version in 2002）Specified in method measure；
Toxicological test parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure；
Skin irritatin parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure.
Specific testing result is shown in Table 1.
Table 1
Wherein, the radius of bacterium circle is smaller, illustrates that antibacterial effect is better.By above-described embodiment, comparative example and example is detected, this
The bacteriostatic agent that invention provides has excellent antibacterial effect, and non-stimulated for skin.
The preferred embodiment of the present invention described in detail above, still, during present invention is not limited to the embodiments described above
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (10)
- A kind of 1. cosmetics preservative based on nipagin esters, it is characterised in that the cosmetics anti-corrosion based on nipagin esters Agent is made of Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent；Wherein, the Phenoxyethanol, methyl hydroxybenzoate, Buddhist nun The weight ratio of the golden ethyl ester of pool and solvent is 35-45：25-33：20-30：50-60.
- 2. the cosmetics preservative according to claim 1 based on nipagin esters, wherein, the Phenoxyethanol, nipalgin The weight ratio of methyl esters, ethylparaben and solvent is 38-42：28-30：25-28：55-58.
- 3. the cosmetics preservative according to claim 1 based on nipagin esters, wherein, the solvent for propane diols and/ Or 1,3 butylene glycol.
- 4. a kind of preparation method of the cosmetics preservative based on nipagin esters, it is characterised in that the preparation method includes：1）Phenoxyethanol is dissolved in solvent so that Phenoxyethanol solution is made；2）By methyl hydroxybenzoate, ethylparaben added to the Phenoxyethanol solution with the obtained change based on nipagin esters Cosmetic preservative；Wherein, the weight ratio of the Phenoxyethanol, methyl hydroxybenzoate, ethylparaben and solvent is 35-45：25-33：20-30： 50-60。
- 5. the cosmetics preservative according to claim 4 based on nipagin esters, wherein, the Phenoxyethanol, nipalgin The weight ratio of methyl esters, ethylparaben and solvent is 38-42：28-30：25-28：55-58.
- 6. the cosmetics preservative according to claim 4 based on nipagin esters, wherein, the solvent for propane diols and/ Or 1,3 butylene glycol.
- 7. the cosmetics preservative based on nipagin esters according to any one in claim 4-6, wherein, in step 1） In, the Phenoxyethanol is mixed with solvent by way of stirring, and stir speed (S.S.) is 2000-3000rpm, during stirring Between be 3-5h.
- 8. the cosmetics preservative based on nipagin esters according to any one in claim 4-6, wherein, in step 2） In, nipagin esters are dissolved in by way of ultrasonic vibration in the Phenoxyethanol solution, and ultrasonic vibration satisfaction is following Condition：Supersonic frequency is 60-80KHz, and the concussion time is 1-2h.
- 9. the cosmetics preservative according to claim 8 based on nipagin esters, wherein, in step 2）In, the Ni Bo The feeding sequence of golden ester is followed successively by methyl hydroxybenzoate, ethylparaben.
- 10. in a kind of 1-3 such as claim as described in any one based on the cosmetics preservative of nipagin esters in cosmetics Application.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710644774.1A CN107913190A (en) | 2017-08-01 | 2017-08-01 | Cosmetics preservative based on nipagin esters and its preparation method and application |
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| CN201710644774.1A CN107913190A (en) | 2017-08-01 | 2017-08-01 | Cosmetics preservative based on nipagin esters and its preparation method and application |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214592A (en) * | 2016-09-09 | 2016-12-14 | 美萃国际贸易（上海）有限公司 | Hair follicle nutrient liquor composition and preparation method thereof |
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- 2017-08-01 CN CN201710644774.1A patent/CN107913190A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214592A (en) * | 2016-09-09 | 2016-12-14 | 美萃国际贸易（上海）有限公司 | Hair follicle nutrient liquor composition and preparation method thereof |
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Application publication date: 20180417 |