CN107496184A - Broad spectrum type cosmetics preservative and its preparation method and application - Google Patents
Broad spectrum type cosmetics preservative and its preparation method and application Download PDFInfo
- Publication number
- CN107496184A CN107496184A CN201710644992.5A CN201710644992A CN107496184A CN 107496184 A CN107496184 A CN 107496184A CN 201710644992 A CN201710644992 A CN 201710644992A CN 107496184 A CN107496184 A CN 107496184A
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- broad spectrum
- spectrum type
- type cosmetics
- phenoxyethanol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of broad spectrum type cosmetics preservative and its preparation method and application, the broad spectrum type cosmetics preservative is made up of Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent；Wherein, the weight ratio of Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent is 20 30：25‑35：40‑50：65‑75.The broad spectrum type cosmetics preservative has excellent antibacterial effect and gentle to skin and then so as to competent skin care item antiseptic, the preparation method raw material is easy to get, is convenient to carry out, process is simple.
Description
Technical field
The present invention relates to preservative, in particular it relates to a kind of broad spectrum type cosmetics preservative and its preparation method and application.
Background technology
Skin care item, it is both the skin-protection product for protecting skin.With social economy continuous progress and material life it is abundant,
Skin care item, no longer it is there was only the thing risen of the rich just in the past.Nowadays skin care item have come into ordinary citizen house as the popular vehicles.It gives people
Spirit, image enhancing serve great effect.Skin care item species is various, and feature is different.By function graduation point, skin care item
There are the skin care item such as moisturizing, whitening, moisturizing, oil-control, anti-aging, sensitive skin, pore refining, blackhead of dispelling, nti-freckle, the fat that disappears.
Either which kind of skin care item is not that can once or twice use, and generally requires to store the long period,
It certainly will need to consider antiseptic effect in storing process, although existing preservative can have certain antiseptic effect, for
Skin has certain stimulation.
The content of the invention
It is an object of the invention to provide a kind of broad spectrum type cosmetics preservative and its preparation method and application, the broad spectrum type
Cosmetic preservative has excellent antibacterial effect and gentle to skin and then so as to competent skin care item antiseptic, simultaneously should
Effect that preparation method has process simple and raw material is easy to get.
To achieve these goals, the invention provides a kind of broad spectrum type cosmetics preservative, the broad spectrum type cosmetics to prevent
Rotten agent is made up of Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent；Wherein, Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent
Weight ratio be 20-30：25-35：40-50：65-75.
Present invention also offers a kind of preparation method of broad spectrum type cosmetics preservative, the Preparation Method includes：
1）Phenoxyethanol is dissolved in solvent so that Phenoxyethanol solution is made；
2）By benzoic acid, dehydroacetic acid added to Phenoxyethanol solution with obtained broad spectrum type cosmetics preservative；
Wherein, the weight ratio of Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent is 20-30：25-35：40-50：65-75.
Invention further provides a kind of application of above-mentioned broad spectrum type cosmetics preservative in cosmetics.
In above-mentioned technical proposal, the present invention has excellent resist by the obtained preservative of synergy of each component
Bacterium effect and gentle to skin and then so as to competent skin care item antiseptic, at the same the preparation method have process simply and
Raw material is easy to get effect.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Embodiment
The embodiment of the present invention is described in detail below.It is it should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
The invention provides a kind of broad spectrum type cosmetics preservative, and the broad spectrum type cosmetics preservative is by Phenoxyethanol, benzene
Formic acid, dehydroacetic acid and solvent composition；Wherein, the weight ratio of Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent is 20-30：
25-35：40-50：65-75.
In above-mentioned broad spectrum type cosmetics preservative, each component content can select in wide scope, but in order that
Obtained preservative has excellent antibacterial effect, it is preferable that Phenoxyethanol, benzoic acid, the weight ratio of dehydroacetic acid and solvent
For 21-23：30-33：45-48：68-72.
In above-mentioned broad spectrum type cosmetics preservative, the specific species of solvent can select in wide scope, but be
Make obtained preservative that there is excellent antibacterial effect, it is preferable that solvent is propane diols and/or 1,3-BDO.
Present invention also offers a kind of preparation method of broad spectrum type cosmetics preservative, the Preparation Method includes：
1）Phenoxyethanol is dissolved in solvent so that Phenoxyethanol solution is made；
2）By benzoic acid, dehydroacetic acid added to Phenoxyethanol solution with obtained broad spectrum type cosmetics preservative；
Wherein, the weight ratio of Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent is 20-30：25-35：40-50：65-75.
In above-mentioned preparation method, each component content can select in wide scope, but in order that obtained anti-corrosion
Agent has excellent antibacterial effect, it is preferable that Phenoxyethanol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 21-23：30-
33：45-48：68-72.
In above-mentioned preparation method, the specific species of solvent can select in wide scope, but in order that obtained
Preservative has excellent antibacterial effect, it is preferable that solvent is propane diols and/or 1,3-BDO.
In the step 1 of above-mentioned preparation method）In, the concrete mode and condition of mixing can select in wide scope,
But in order that obtained preservative has excellent antibacterial effect, it is preferable that in step 1）In, Phenoxyethanol passes through with solvent
The mode of stirring is mixed, and stir speed (S.S.) is 2000-3000rpm, mixing time 3-5h.
In the step 2 of above-mentioned preparation method）In, the concrete mode and condition of mixing can select in wide scope,
But in order that obtained preservative has excellent antibacterial effect, it is preferable that in step 2）In, nipagin esters are shaken by ultrasound
The mode swung is dissolved in Phenoxyethanol solution, and ultrasonic vibration meets following condition：Supersonic frequency is 60-80KHz, during concussion
Between be 1-2h.
In the step 2 of above-mentioned preparation method）In, the feeding sequence of nipagin esters can select in wide scope, still
In order that obtained preservative has excellent antibacterial effect, it is preferable that in step 2）In, nipagin esters pass through ultrasonic vibration
Mode is dissolved in Phenoxyethanol solution, it is preferable that the feeding sequence of nipagin esters is followed successively by benzoic acid, dehydroacetic acid.
Invention further provides a kind of application of above-mentioned broad spectrum type cosmetics preservative in cosmetics.
The present invention will be described in detail by way of examples below.
Embodiment 1
1）Phenoxyethanol is passed through into stirring（Stir speed (S.S.) is 2000rpm, mixing time 3h）It is dissolved in solvent（Propane diols）With system
Obtain Phenoxyethanol solution；
2）Benzoic acid, dehydroacetic acid are added to Phenoxyethanol solution successively, and carry out ultrasonic vibration（Supersonic frequency is
60KHz, concussion time are 1h）So that broad spectrum type cosmetics preservative A1 is made；Wherein, Phenoxyethanol, benzoic acid, dehydroacetic acid and
The weight ratio of solvent is 20：25：40：65.
Embodiment 2
1）Phenoxyethanol is passed through into stirring（Stir speed (S.S.) is 3000rpm, mixing time 5h）It is dissolved in solvent（1,3 butylene glycol）
So that Phenoxyethanol solution is made；
2）Benzoic acid, dehydroacetic acid are added to Phenoxyethanol solution successively, and carry out ultrasonic vibration（Supersonic frequency is
80KHz, concussion time are 2h）So that broad spectrum type cosmetics preservative A2 is made；Wherein, Phenoxyethanol, benzoic acid, dehydroacetic acid and
The weight ratio of solvent is 30：35：50：75.
Embodiment 3
Method according to embodiment 1 carries out that broad spectrum type cosmetics preservative A3 is made, except that, Phenoxyethanol, benzoic acid,
The weight of dehydroacetic acid and solvent ratio is 22：31：47：70.
Embodiment 4
Method according to embodiment 1 carries out that broad spectrum type cosmetics preservative A4 is made, except that, Phenoxyethanol, benzoic acid,
The weight of dehydroacetic acid and solvent ratio is 21：30：45：68.
Embodiment 5
Method according to embodiment 1 carries out that broad spectrum type cosmetics preservative A5 is made, except that, Phenoxyethanol, benzoic acid,
The weight of dehydroacetic acid and solvent ratio is 23：33：48：72.
Embodiment 6
Method according to embodiment 1 carries out that broad spectrum type cosmetics preservative A6 is made, except that, step 2）In, nipalgin
The feeding sequence of ester is to be launched benzoic acid, dehydroacetic acid simultaneously.
Comparative example 1
Obtained broad spectrum type cosmetics preservative B1 is carried out according to the method for embodiment 1 according to embodiment, except that, benzene oxygen second
Alcohol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 15：30：45：70.
Comparative example 2
Obtained broad spectrum type cosmetics preservative B2 is carried out according to the method for embodiment 1 according to embodiment, except that, benzene oxygen second
Alcohol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 35：30：45：70.
Comparative example 3
Obtained broad spectrum type cosmetics preservative B3 is carried out according to the method for embodiment 1 according to embodiment, except that, benzene oxygen second
Alcohol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 25：20：45：70.
Comparative example 4
Obtained broad spectrum type cosmetics preservative B4 is carried out according to the method for embodiment 1 according to embodiment, except that, benzene oxygen second
Alcohol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 25：38：45：70.
Comparative example 5
Obtained broad spectrum type cosmetics preservative B5 is carried out according to the method for embodiment 1 according to embodiment, except that, benzene oxygen second
Alcohol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 25：28：35：70.
Comparative example 6
Obtained broad spectrum type cosmetics preservative B6 is carried out according to the method for embodiment 1 according to embodiment, except that, benzene oxygen second
Alcohol, benzoic acid, the weight ratio of dehydroacetic acid and solvent are 25：28：55：70.
Detect example 1
Above-mentioned bacteriostatic agent is added in vaseline and beeswax lipstick is made, then detect its performance by the following method, wherein,
Biocidal property parameter is by defending method prison hair [2002] the 229th《Disinfection technology standard》（Version in 2002）Specified in method measure；
Toxicological test parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure；
Skin irritatin parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure.
Specific testing result is shown in Table 1.
Table 1
Wherein, the radius of bacterium circle is smaller, illustrates that antibacterial effect is better.By above-described embodiment, comparative example and example is detected, this
The bacteriostatic agent that invention provides has excellent antibacterial effect, and non-stimulated for skin.
The preferred embodiment of the present invention described in detail above, still, the present invention are not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (10)
1. a kind of broad spectrum type cosmetics preservative, it is characterised in that the broad spectrum type cosmetics preservative is by Phenoxyethanol, benzene first
Acid, dehydroacetic acid and solvent composition；Wherein, the weight ratio of the Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent is 20-30：
25-35：40-50：65-75.
2. broad spectrum type cosmetics preservative according to claim 1, wherein, the Phenoxyethanol, benzoic acid, dehydroacetic acid
Weight ratio with solvent is 21-23：30-33：45-48：68-72.
3. broad spectrum type cosmetics preservative according to claim 1, wherein, the solvent is propane diols and/or 1,3- fourth
Glycol.
4. a kind of preparation method of broad spectrum type cosmetics preservative, it is characterised in that the preparation method includes：
1）Phenoxyethanol is dissolved in solvent so that Phenoxyethanol solution is made；
2）By benzoic acid, dehydroacetic acid added to the Phenoxyethanol solution with the obtained broad spectrum type cosmetics preservative；
Wherein, the weight ratio of the Phenoxyethanol, benzoic acid, dehydroacetic acid and solvent is 20-30：25-35：40-50：65-75.
5. broad spectrum type cosmetics preservative according to claim 4, wherein, the Phenoxyethanol, benzoic acid, dehydroacetic acid
Weight ratio with solvent is 21-23：30-33：45-48：68-72.
6. broad spectrum type cosmetics preservative according to claim 4, wherein, the solvent is propane diols and/or 1,3- fourth
Glycol.
7. the broad spectrum type cosmetics preservative according to any one in claim 4-6, wherein, in step 1）In, it is described
Phenoxyethanol is mixed with solvent by way of stirring, and stir speed (S.S.) is 2000-3000rpm, mixing time 3-
5h。
8. the broad spectrum type cosmetics preservative according to any one in claim 4-6, wherein, in step 2）In, Ni Bo
Golden ester is dissolved in by way of ultrasonic vibration in the Phenoxyethanol solution, and the ultrasonic vibration meets following condition：It is super
Acoustic frequency is 60-80KHz, and the concussion time is 1-2h.
9. broad spectrum type cosmetics preservative according to claim 8, wherein, in step 2）In, the throwing of the nipagin esters
Material order is followed successively by benzoic acid, dehydroacetic acid.
A kind of 10. application of the broad spectrum type cosmetics preservative in 1-3 such as claim as described in any one in cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710644992.5A CN107496184A (en) | 2017-08-01 | 2017-08-01 | Broad spectrum type cosmetics preservative and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710644992.5A CN107496184A (en) | 2017-08-01 | 2017-08-01 | Broad spectrum type cosmetics preservative and its preparation method and application |
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| Publication Number | Publication Date |
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| CN107496184A true CN107496184A (en) | 2017-12-22 |
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| CN201710644992.5A Pending CN107496184A (en) | 2017-08-01 | 2017-08-01 | Broad spectrum type cosmetics preservative and its preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407682A (en) * | 2020-04-14 | 2020-07-14 | 南京泛成生物科技有限公司 | Cosmetic preservative and preparation method and application thereof |
| CN115444769A (en) * | 2022-09-01 | 2022-12-09 | 陕西华润实业公司 | Compound cosmetic preservative and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511205A (en) * | 2016-12-09 | 2017-03-22 | 苏州宝丽洁日化有限公司 | Antiallergic skin-caring lotion and wet tissue and preparation methods of antiallergic skin-caring lotion and wet tissue |
-
2017
- 2017-08-01 CN CN201710644992.5A patent/CN107496184A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511205A (en) * | 2016-12-09 | 2017-03-22 | 苏州宝丽洁日化有限公司 | Antiallergic skin-caring lotion and wet tissue and preparation methods of antiallergic skin-caring lotion and wet tissue |
Non-Patent Citations (1)
| Title |
|---|
| 施昌松等: "化妆品中微生物与防腐体系的构建", 《日用化学品科学》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407682A (en) * | 2020-04-14 | 2020-07-14 | 南京泛成生物科技有限公司 | Cosmetic preservative and preparation method and application thereof |
| CN111407682B (en) * | 2020-04-14 | 2021-05-04 | 南京泛成生物科技有限公司 | Cosmetic preservative and preparation method and application thereof |
| CN115444769A (en) * | 2022-09-01 | 2022-12-09 | 陕西华润实业公司 | Compound cosmetic preservative and preparation method and application thereof |
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Application publication date: 20171222 |