CN107837203A - IPBC/ diazonium alkyl imidazole urea combined bacteriostats and its preparation method and application - Google Patents
IPBC/ diazonium alkyl imidazole urea combined bacteriostats and its preparation method and application Download PDFInfo
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- CN107837203A CN107837203A CN201710644967.7A CN201710644967A CN107837203A CN 107837203 A CN107837203 A CN 107837203A CN 201710644967 A CN201710644967 A CN 201710644967A CN 107837203 A CN107837203 A CN 107837203A
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- Prior art keywords
- ipbc
- alkyl imidazole
- imidazole urea
- diazonium alkyl
- butanediols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of IPBC/ diazonium alkyl imidazole urea combined bacteriostat and its preparation method and application, and the bacteriostatic agent is by IPBC, diazonium alkyl imidazole urea and 1,3 butanediols composition；Wherein, IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 45 55：45‑55：20 40 or 30 40：58‑70：20‑40.The IPBC/ diazonium alkyl imidazole urea combined bacteriostats have excellent antibacterial effect and gentle to skin and then so as to competent skin care item antiseptic, while the preparation method process is simple, and raw material is easy to get.
Description
Technical field
The present invention relates to bacteriostatic agent, in particular it relates to a kind of IPBC/ diazonium alkyl imidazole urea combined bacteriostat and its preparation
Methods and applications.
Background technology
Skin care item, it is both the skin-protection product for protecting skin.With social economy continuous progress and material life it is abundant,
Skin care item, no longer it is there was only the thing risen of the rich just in the past.Nowadays skin care item have come into ordinary citizen house as the popular vehicles.It gives people
Spirit, image enhancing serve great effect.Skin care item species is various, and feature is different.By function graduation point, skin care item
There are the skin care item such as moisturizing, whitening, moisturizing, oil-control, anti-aging, sensitive skin, pore refining, blackhead of dispelling, nti-freckle, the fat that disappears.
Either which kind of skin care item is not that can once or twice use, and generally requires to store the long period,
It certainly will need to consider antiseptic effect in storing process, although existing preservative can have certain antiseptic effect, for
Skin has certain stimulation.
The content of the invention
It is an object of the invention to provide a kind of IPBC/ diazonium alkyl imidazole urea combined bacteriostat and preparation method thereof and answer
There is excellent antibacterial effect and gentle to skin and then enable it to, the IPBC/ diazonium alkyl imidazole urea combined bacteriostats
Enough competent skin care item antiseptic, while the preparation method has process simple and raw material is easy to get effect.
To achieve these goals, the invention provides a kind of IPBC/ diazonium alkyl imidazole urea combined bacteriostat, this is antibacterial
Agent is by IPBC（Iodine IPBC）, diazonium alkyl imidazole urea and 1,3 butanediols composition；Wherein, IPBC, diazonium alkyl
The weight of imidazoles urea and 1,3 butanediols ratio is 45-55：45-55：20-40 or 30-40：58-70：20-40.
Present invention also offers a kind of preparation method of IPBC/ diazonium alkyl imidazole urea combined bacteriostat, the preparation method
Including：
1）IPBC is dissolved in 1,3 butanediols and forms solution I；
2）Diazonium alkyl imidazole urea is dissolved in solution I IPBC/ diazonium alkyl imidazole urea combined bacteriostats are made；
Wherein, IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 45-55：45-55：20-40 or 30-40：
58-70：20-40.
Invention further provides a kind of above-mentioned IPBC/ diazonium alkyl imidazole urea combined bacteriostats in skin care item
Application.
In the above-mentioned technical solutions, the present invention is made by IPBC, diazonium alkyl imidazole urea and 1, the collaboration of 3 butanediol threes
With so cause obtained bacteriostatic agent that there are excellent antibacterial effect and and then so as to competent skin care item gentle to skin
Antiseptic, while the preparation method has process simple and raw material is easy to get effect.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Embodiment
The embodiment of the present invention is described in detail below.It is it should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
The invention provides a kind of IPBC/ diazonium alkyl imidazole urea combined bacteriostat, the bacteriostatic agent is by IPBC, diazonium alkyl
Imidazoles urea and 1,3 butanediols composition；Wherein, IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 45-55：45-
55：20-40 or 30-40：58-70：20-40.
In the present invention, the proportioning of each component can select in wide scope, but in order that obtained bacteriostatic agent has
There is more excellent antibacterial effect, it is preferable that IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 48-52：48-
52：28-32 or 34-36：62-66：28-32.
Present invention also offers a kind of preparation method of IPBC/ diazonium alkyl imidazole urea combined bacteriostat, the preparation method
Including：
1）IPBC is dissolved in 1,3 butanediols and forms solution I；
2）Diazonium alkyl imidazole urea is dissolved in solution I IPBC/ diazonium alkyl imidazole urea combined bacteriostats are made；
Wherein, IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 45-55：45-55：20-40 or 30-40：
58-70：20-40.
In above-mentioned preparation method, the proportioning of each component can select in wide scope, but in order that obtained suppression
Microbial inoculum has more excellent antibacterial effect, it is preferable that IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 48-
52：48-52：28-32 or 34-36：62-66：28-32.
In above-mentioned preparation method, the mode that IPBC is dissolved in 1,3 butanediols can select in wide scope, but in order to
Make obtained bacteriostatic agent that there is more excellent antibacterial effect and stability, it is preferable that in step 1）In, IPBC is shaken by ultrasound
The mode swung is dissolved in 1,3 butanediols, and the condition of ultrasonic vibration is：Supersonic frequency is 40-50KHz, and concussion temperature is 55-
70 DEG C, the concussion time is 2-4h.
Similarly, in step 2）In, diazonium alkyl imidazole urea can be dissolved in solution I in several ways, but in order that
Obtained bacteriostatic agent has more excellent antibacterial effect and stability, it is preferable that in step 2）In, the diazonium alkyl imidazole
Urea is mixed with the solution I by way of stirring, and the speed stirred is 1500-2000rpm, and mixing time is
25-40min。
Invention further provides a kind of above-mentioned IPBC/ diazonium alkyl imidazole urea combined bacteriostats in skin care item
Application.
The present invention will be described in detail by way of examples below.
Embodiment 1
1）Iodine IPBC is added in 1,3 butanediols, then carries out ultrasonic vibration（Supersonic frequency is 45KHz,
It is 60 DEG C to shake temperature, and the concussion time is 3h）Form solution I；
2）Diazonium alkyl imidazole urea is placed in solution I and passes through stirring（Speed is 1800rpm, time 30min）It is made
IPBC/ diazonium alkyl imidazole urea combined bacteriostats A1；Wherein, IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols are
50：50：30.
Embodiment 2
Bacteriostatic agent A2 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 48：48：28.
Embodiment 3
Bacteriostatic agent A3 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 52：52：32.
Embodiment 4
Bacteriostatic agent A4 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 35：64：30.
Embodiment 5
Bacteriostatic agent A5 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 34：62：30.
Embodiment 6
Bacteriostatic agent A6 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 36：66：32.
Comparative example 1
Bacteriostatic agent B1 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 40：50：30.
Comparative example 2
Bacteriostatic agent B2 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 56：50：30.
Comparative example 3
Bacteriostatic agent B3 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 50：40：30.
Comparative example 4
Bacteriostatic agent B4 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 50：60：30.
Comparative example 5
Bacteriostatic agent B5 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 29：64：30.
Comparative example 6
Bacteriostatic agent B6 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 42：64：30.
Comparative example 7
Bacteriostatic agent B7 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 35：45：30.
Comparative example 8
Bacteriostatic agent B8 is carried out according to the method for embodiment 1, except that：IPBC, diazonium alkyl imidazole urea and 1,3 butanediols
Weight ratio is 35：75：30.
Detect example 1
Above-mentioned bacteriostatic agent is added in vaseline and beeswax lipstick is made, then detect its performance by the following method, wherein,
Biocidal property parameter is by defending method prison hair [2002] the 229th《Disinfection technology standard》（Version in 2002）Specified in method measure；
Toxicological test parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure；
Skin irritatin parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure.
Specific testing result is shown in Table 1 and table 2.
Wherein, the radius of bacterium circle is smaller, illustrates that antibacterial effect is better.By above-described embodiment, comparative example and example is detected, this
The bacteriostatic agent that invention provides has excellent antibacterial effect, and non-stimulated for skin.
The preferred embodiment of the present invention described in detail above, still, the present invention are not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (8)
1. a kind of IPBC/ diazonium alkyl imidazole urea combined bacteriostat, it is characterised in that the bacteriostatic agent is by IPBC（Iodine propine is just
Butylamine formic acid esters）, diazonium alkyl imidazole urea and 1,3 butanediols composition；Wherein, the IPBC, diazonium alkyl imidazole urea and 1,3 fourths
The weight ratio of glycol is 45-55：45-55：20-40 or 30-40：58-70：20-40.
2. bacteriostatic agent according to claim 1, wherein, the IPBC, diazonium alkyl imidazole urea and 1, the weight of 3 butanediols
Than for 48-52：48-52：28-32 or 34-36：62-66：28-32.
A kind of 3. preparation method of IPBC/ diazonium alkyl imidazole urea combined bacteriostat, it is characterised in that the preparation method bag
Include：
1）IPBC is dissolved in 1,3 butanediols and forms solution I；
2）Diazonium alkyl imidazole urea and the solution I are mixed to prepare the IPBC/ diazonium alkyl imidazole urea combined bacteriostat；
Wherein, the IPBC, diazonium alkyl imidazole urea and 1, the weight ratio of 3 butanediols is 45-55：45-55：20-40 or 30-
40：58-70：20-40.
4. preparation method according to claim 3, wherein, the IPBC, diazonium alkyl imidazole urea and 1, the weight of 3 butanediols
It is 48-52 to measure ratio：48-52：28-32 or 34-36：62-66：28-32.
5. the preparation method according to claim 3 or 4, wherein, in step 1）In, side that the IPBC passes through ultrasonic vibration
Formula is dissolved in 1,3 butanediols.
6. preparation method according to claim 5, wherein, in step 1）In, the condition of the ultrasonic vibration is：Supersonic frequency
Rate is 40-50KHz, and concussion temperature is 55-70 DEG C, and the concussion time is 2-4h.
7. according to the preparation method described in claim or 4, wherein, in step 2）In, the diazonium alkyl imidazole urea with it is described
Solution I is mixed by way of stirring, and the speed stirred is 1500-2000rpm, and mixing time is 25-
40min。
A kind of 8. application of the IPBC/ diazonium alkyl imidazole urea combined bacteriostats in skin care item as claimed in claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710644967.7A CN107837203A (en) | 2017-08-01 | 2017-08-01 | IPBC/ diazonium alkyl imidazole urea combined bacteriostats and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710644967.7A CN107837203A (en) | 2017-08-01 | 2017-08-01 | IPBC/ diazonium alkyl imidazole urea combined bacteriostats and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107837203A true CN107837203A (en) | 2018-03-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710644967.7A Pending CN107837203A (en) | 2017-08-01 | 2017-08-01 | IPBC/ diazonium alkyl imidazole urea combined bacteriostats and its preparation method and application |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535385A (en) * | 2013-10-25 | 2014-01-29 | 北京桑普生物化学技术有限公司 | Plant extract and synergist contained antimicrobial composition |
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2017
- 2017-08-01 CN CN201710644967.7A patent/CN107837203A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535385A (en) * | 2013-10-25 | 2014-01-29 | 北京桑普生物化学技术有限公司 | Plant extract and synergist contained antimicrobial composition |
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Application publication date: 20180327 |
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