CN110327282A - A kind of dandruff control shampoo containing and preparation process improving scalp epidermis microbial flora - Google Patents
A kind of dandruff control shampoo containing and preparation process improving scalp epidermis microbial flora Download PDFInfo
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- CN110327282A CN110327282A CN201910764877.0A CN201910764877A CN110327282A CN 110327282 A CN110327282 A CN 110327282A CN 201910764877 A CN201910764877 A CN 201910764877A CN 110327282 A CN110327282 A CN 110327282A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses the dandruff control shampoo containings that one kind can improve scalp epidermis microbial flora, and raw material includes: water, dimethyl silicone polymer, ethylene glycol stearate, sodium lauroyl sarcosine, Polyquaternium-10, cetostearyl alcohol, ammonium chloride, great bilberry fruit extracts, celery seed extract, silk hydroiyzing liquid, zinc pyrithione, piroctone olamine salt, EDETATE SODIUM, surfactant, preservative, Artemisinin, rosemary water.The preparation process of also disclosed above-mentioned shampoo.The shampoo improves the resistance of scalp epidermis to improve the microbial environment of scalp epidermis, has the function that effectively anti-dandruff anti-antidandruff recurrence.
Description
Technical field
The present invention relates to shampoo technical field more particularly to it is a kind of reduce pug use and high intensity pressure-resistant brick and its
Preparation method.
Background technique
The shampoo product of anti-dandruff is numerous in the market, and according to research at present, the principal element that dandruff generates is scalp
Caused by sebum metabolic disorder and pityrosporum furfur (chlosma).Due to the growth of disorder, chlosma by sebum secretion,
The influence of the factors such as private medical service generates the puzzlement of dandruff and itching of the scalp.
Anti-dandruff shampoo in the market is mainly the bacteriostatic agent of a kind of fungi and bacterium with zinc pyrithione (ZPT),
It makes an addition in shampoo and reaches the purposes of anti-dandruff, inhibit growth or honeysuckle, lemongrass, the tea oil of chlosma
Plant fungicide reaches approximate effect.It is this anti-dandruff to carry out in a manner of removing dandruff to sterilize, due to being only that will cause
Germ removal, and the balance of the microbial flora of scalp epidermis is destroyed, dandruff is easy to recur or generates other scalp problems.
Also there is by way of nourishing the shampoo for inhibiting pernicious bacteria to promote scalp metabolic balance in the prior art, but can not reach
To the removal anti-dandruff purpose of pernicious bacteria.
Summary of the invention
It is an object of the invention to propose that one kind can improve the dandruff control shampoo containing and preparation work of scalp epidermis microbial flora
Skill, the shampoo is with zinc pyrithione, celery seed extract and silk hydroiyzing liquid Synergistic biocidal, antibacterial, to improve scalp epidermis
Microbial environment, improve the resistance of scalp epidermis, have the function that effectively anti-dandruff anti-antidandruff recurrence.
To achieve this purpose, the present invention adopts the following technical scheme:
A kind of dandruff control shampoo containing improving scalp epidermis microbial flora, raw material in parts by weight include:
55-62 parts of water, 2.5-3.5 parts of dimethyl silicone polymer, 2.2-2.6 parts of ethylene glycol stearate, lauroyl flesh ammonia
Sour sodium 1.4-1.8 parts, it is 0.15-0.25 parts of Polyquaternium-10,0.4-0.6 parts of cetostearyl alcohol, 0.2-0.4 parts of ammonium chloride, sincere
0.05-0.15 parts of this vaccinium ashei extract, 1-3 parts of celery seed extract, 1-3 parts of silk hydroiyzing liquid, zinc pyrithione 0.08-
0.12 part, 0.04-0.06 parts of piroctone olamine salt, 0.08-0.12 parts of EDETATE SODIUM, 18.8-25.2 parts of surfactant
With 0.65-1.25 parts of preservative.
Further, its raw material in parts by weight of dandruff control shampoo containing further include: 0.5 part of Artemisinin and rosemary water
0.5-1 parts.
Further, surfactant is selected from cationic surfactant, anion active agent, non-ionic surfactant
One of agent, amphoteric surfactant and amino acid surfactant are a variety of.
Further, the surfactant in parts by weight includes: 13-17 parts of laureth sulfuric ester ammonium, coconut palm
2.5-3 parts of oleamide MEA, 1.5-2.5 parts of lauroylamidopropyl betaine, 1-1.5 parts of sodium cocoyl glycinate and myristoyl
.8-1.2 parts of pg dimonium chloride phosphoesterase 30 of amine propyl.
Further, the preservative in parts by weight includes: 0.15-0.25 parts of Climbazole, DMDM hydantoin
0.2-0.4 parts and methylchloroisothiazandnone 0.3-0.6 parts.
It further, further include in parts by weight 0.6-1 parts of suspension stabilizer in shampoo formula, it is described suspending stabilized
Agent is two (hydrogenated-tallow group) phthalic acid acyls.
Further, the formula of shampoo in parts by weight are as follows:
55-62 parts of water, 2.5-3.5 parts of dimethyl silicone polymer, 2.2-2.6 parts of ethylene glycol stearate, lauroyl flesh ammonia
Sour sodium 1.4-1.8 parts, it is 0.15-0.25 parts of Polyquaternium-10,0.4-0.6 parts of cetostearyl alcohol, 0.2-0.4 parts of ammonium chloride, sincere
0.05-0.15 parts of this vaccinium ashei extract, 1-3 parts of celery seed extract, 1-3 parts of silk hydroiyzing liquid, zinc pyrithione 0.08-
0.12 part, 0.04-0.06 parts of piroctone olamine salt, 0.08-0.12 parts of EDETATE SODIUM, laureth sulfuric ester ammonium 13-
17 parts, 2.5-3 parts of coconut oleoyl amine MEA, 1.5-2.5 parts of lauroylamidopropyl betaine, 1-1.5 parts of sodium cocoyl glycinate, meat
.8-1.2 parts of cardamom amido propyl pg dimonium chloride phosphoesterase 30,0.15-0.25 parts of Climbazole, DMDM hydantoin
0.2-0.4 parts, 0.3-0.6 parts of methylchloroisothiazandnone, two 0.6-1 parts of (hydrogenated-tallow group) phthalic acid acyls, sweet wormwood mention
Take 0.5 part and 0.5-1 parts of rosemary water of object.
Further, the formula of shampoo in parts by weight are as follows:
57.75-61.75 parts of water, 15 parts of laureth sulfuric ester ammonium, 3 parts of dimethyl silicone polymer, coconut oleoyl amine MEA
2.8 parts, 2.4 parts of ethylene glycol stearate, 2 parts of lauroylamidopropyl betaine, 1.6 parts of sodium lauroyl sarcosine, cocounut oil acyl it is sweet
1.3 parts of propylhomoserin sodium, two 0.8 part of (hydrogenated-tallow group) phthalic acid amides, 0.2 part of Polyquaternium-10, cetostearyl alcohol 0.5
Part, 0.3 part of ammonium chloride, 0.1 part of great bilberry fruit extracts, 1-3 parts of celery seed extract, myristamide propyl PG- bis-
1 part of ammonio methacrylate phosphate, 1-3 parts of silk hydroiyzing liquid, 0.1 part of zinc pyrithione, 0.2 part of Climbazole, piroctone ethyl alcohol
0.05 part of amine salt, 0.1 part of EDETATE SODIUM, 0.3 part of DMDM hydantoin, 0.5 part of methylchloroisothiazandnone, Artemisinin
0.5 part and 0.8 part of rosemary water.
The preparation process of above-mentioned dandruff control shampoo containing, comprising the following steps:
(1), water and EDETATE SODIUM are added to the container stirring and dissolving according to formula ratio；
(2) laureth sulfuric ester ammonium, poly dimethyl silicon are sequentially added according to formula ratio in the liquid in step (1)
Oxygen alkane, coconut oleoyl amine MEA, ethylene glycol stearate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, the sweet ammonia of cocounut oil acyl
Sour sodium, two (hydrogenated-tallow group) phthalic acid amides, Polyquaternium-10, cetostearyl alcohol, ammonium chloride and celery seed extract
Object stirs evenly；
(3), Climbazole, piroctone olamine are sequentially added according to formula ratio into mixture made from step (2)
Salt, DMDM hydantoin, methylchloroisothiazandnone, stirring are complete to dissolving；
(4), great bilberry fruit extracts, Pork and beans are sequentially added according to formula ratio into mixture made from step (3)
Cool amido propyl pg dimonium chloride phosphate, silk hydroiyzing liquid, zinc pyrithione, Artemisinin and rosemary water, stirring
Uniformly up to the dandruff control shampoo containing.
Further, in step (4), the pH of the shampoo is 5.5-6.5, viscosity 5000-6000Pas.
Further, step (1)-(4) carry out at normal temperature.
The invention has the benefit that
Senkyunolide (Senkyunolide) in celery (APIUM GRAVEOLENS) seed extract, can dramatically reduction
Scalp sebum generates, and limits fat intake, controls flora growth；And antibacterial peptide is promoted to generate, improve scalp flora, strengthens epidermis
Cell film.Silk hydroiyzing liquid improves and maintenance scalp micro-ecological environment, enhances the moisture retention and appropriate inhibition scalp of scalp
Two kinds of the normal level of microbial population solves microorganism excess, to reach more effective anti-dandruff effect.
Using zinc pyrithione and piroctone olamine salt as fungicide in formula of the invention, with celery seed extract,
Silk hydroiyzing liquid and great bilberry fruit extracts carry out antibacterial and improve scalp environment, extract zinc pyrithione, celery seed
It is object and silk hydroiyzing liquid Synergistic biocidal, antibacterial, to improve the microbial environment of scalp epidermis, the resistance of scalp epidermis is improved,
Have the function that effectively anti-dandruff anti-antidandruff recurrence.Myristamide propyl pg dimonium chloride phosphate is cation form
Face activating agent, the effect of can promote zinc pyrithione (ZPT), improve fungistatic effect.Therefore, pyrrole sulphur is used only in formula of the invention
0.08-0.12 parts of zinc can arrive to good fungistatic effect.
Detailed description of the invention
Fig. 1 is commercially available shampoo (shampoo), the commercially available zinc pyrithione for containing 2% weight percent and hair washing of the invention
Water carries out the result figure of the minimum inhibitory concentration test to chlosma saccharomycete；
Fig. 2 is that oiliness scalp testee and dry scalp testee are washed hair using shampoo of the present invention and placebo respectively
Effect picture；
Fig. 3 is oiliness scalp testee and dry scalp testee during using shampoo of the present invention to itching of the scalp
Degree marking figure；
Fig. 4 is oiliness scalp testee and dry scalp testee during using shampoo of the present invention to dandruff size
It gives a mark and schemes with dandruff degree；
Fig. 5 is the photo that microshot is carried out to scalp.
Specific embodiment
With reference to the accompanying drawing and specific embodiment further illustrates technical solution of the present invention.
A kind of dandruff control shampoo containing improving scalp epidermis microbial flora, raw material in parts by weight include:
55-62 parts of water, 2.5-3.5 parts of dimethyl silicone polymer, 2.2-2.6 parts of ethylene glycol stearate, lauroyl flesh ammonia
Sour sodium 1.4-1.8 parts, it is 0.15-0.25 parts of Polyquaternium-10,0.4-0.6 parts of cetostearyl alcohol, 0.2-0.4 parts of ammonium chloride, sincere
0.05-0.15 parts of this vaccinium ashei extract, 1-3 parts of celery seed extract, 1-3 parts of silk hydroiyzing liquid, zinc pyrithione 0.08-
0.12 part, 0.04-0.06 parts of piroctone olamine salt, 0.08-0.12 parts of EDETATE SODIUM, 18.8-25.2 parts of surfactant
With 0.65-1.25 parts of preservative.
In formula of the invention, the effect of each component is as follows:
Dimethyl silicone polymer has physiological inertia, good chemical stability.Dimethyl silicone polymer energy and wool
The mixing of the surfactants such as rouge, stearyl alcohol, cetanol, glycerin monostearate, tween, sapn is used as emulsion-type matrix.Poly- two
Methylsiloxane has good moisture retention, has greasy property, anti-ultraviolet effect, and good permeability has apparent anti-
Dirt function.Dimethyl silicone polymer is very good to the permeability of skin, can also deepen the color of hair, and hair is helped to keep certainly
Right gloss.
Sodium lauroyl sarcosine is all more stable to heat, acid, alkali, smaller to skin irritation, degreasing is weaker, has
Antibiotic and sterilizing, mould proof and anticorrosive, antistatic effect；With good foaminess, and foam is fine and smooth, lasting.
Polyquaternium-10 forms transparent, continuous film for water energy maintenance hair jag of having one's hair wash on hair；It can mention
For splendid performance of keeping humidity, improve damaged hair.Polyquaternium-10 has superior water-soluble and adsorption capacity cationic fiber
Plain polymer, can be compatible with anion, cation, nonionic and zwitterionic surfactant, and irritation is low, unique sun
Ionic nature can repair impaired hair protein matrix, and hair is kept to moisten, and assign the superior carding property of hair and glossy cunning
Refreshing feeling.
Ammonium chloride is thickener, and great bilberry fruit extracts are antioxidants.
Senkyunolide (Senkyunolide) in celery seed extract, can dramatically, which reduces scalp sebum, generates, limitation
Fat intake controls flora growth；And antibacterial peptide is promoted to generate, improve scalp flora, strengthens epidermal cell cell membrane.
Include fibroin in silk hydroiyzing liquid, there are a variety of amino acid, have anti-inflammatory protective effect to scalp.Silk hydrolysis
Liquid can improve and safeguard scalp micro-ecological environment, enhance the moisture retention and the appropriate normal water for inhibiting scalp microbial population of scalp
It is two kinds flat, microorganism excess is solved, to reach more effective anti-dandruff effect
Zinc pyrithione is the bacteriostatic agent of a kind of fungi and bacterium, can inhibit the growth of chlosma, zinc pyrithione can also press down
Gram-negative, positive bacteria and fungus growth processed, there is stronger sterilizing ability.
Piroctone olamine salt is anti-dandruff agent, fundamentally blocks the outer of dandruff generation with antioxidation by sterilizing
Portion's channel, to effectively eradicate dandruff, stopping head itching.
Using zinc pyrithione and piroctone olamine salt as fungicide in formula of the invention, with celery seed extract,
Silk hydroiyzing liquid and great bilberry fruit extracts carry out antibacterial and improve scalp environment, extract zinc pyrithione, celery seed
It is object and silk hydroiyzing liquid Synergistic biocidal, antibacterial, to improve the microbial environment of scalp epidermis, the resistance of scalp epidermis is improved,
Have the function that effectively anti-dandruff anti-antidandruff recurrence.
According to needs of production, essence and color material can be added in shampoo of the invention.
It preferably, include .8-1.2 parts of myristamide propyl pg dimonium chloride phosphoesterase 30 in surfactant.
Myristamide propyl pg dimonium chloride phosphate (PG- quaternary ammonium salt is referred to as in this patent) is cation surface activating
Agent, the effect of can promote zinc pyrithione (ZPT), improve fungistatic effect.Therefore, zinc pyrithione is used only in formula of the invention
0.08-0.12 parts can arrive to good fungistatic effect, and zinc pyrithione cooperates with celery seed extract, silk hydrolysis under this dosage
Liquid and great bilberry fruit extracts reach good fungistatic effect.
Further, its raw material in parts by weight of dandruff control shampoo containing further include: 0.5 part of Artemisinin, rosemary water
0.5-1 parts.Artemisinin have antibacterial action, to staphylococcus epidermis, micrococcus catarrhalis, bacillus anthracis, corynebacterium diphtheriae have compared with
Strong bacteriostasis.Rosemary has excellent antioxygenic property, also has bactericidal effect.
Further, surfactant is selected from cationic surfactant, anion active agent, non-ionic surfactant
One of agent, amphoteric surfactant and amino acid surfactant are a variety of.When a plurality of types of surface-actives of selection
When agent, realizes ideal washing foaming effect and shampoo is made to have suitable viscosity, while submissive using the hair of this shampoo,
Antistatic effect.
Further, the surfactant in parts by weight includes: 13-17 parts of laureth sulfuric ester ammonium, coconut palm
2.5-3 parts of oleamide MEA, 1.5-2.5 parts of lauroylamidopropyl betaine, 1-1.5 parts of sodium cocoyl glycinate and myristoyl
.8-1.2 parts of pg dimonium chloride phosphoesterase 30 of amine propyl.
Laureth sulfuric ester ammonium is anion active agent.Myristamide propyl pg dimonium chloride phosphate
For cationic surfactant.Coconut oleoyl amine MEA (coconut palm oleoyl monoethanolamine) is slightly soluble in water, is nonionic surface active agent,
With excellent decontamination, emulsification, foaming, foam stabilizing, dispersion, solubilising power, there is excellent calcium and magnesium dispersibility.
Ethylene glycol stearate and other surfaces activating agent intermiscibility are good, the pearl effect with shampoo, and can increase
Add the viscosity of product, also there is skin care, hair care hair care and antistatic property.
Lauroylamidopropyl betaine be extremely low irritating amphoteric surfactant, can with cation, anion, it is non-from
Sublist face active ingredient also has good hard water resistance property, resists with ideal washing, conditioning, antistatic and bactericidal effect
Static behaviour and biological degradability；Lauroylamidopropyl betaine has excellent flexibility, to skin action temperature and, foaming abundancy and
Stablize, and there is good viscosity-adjusting agent to act on.Lauroylamidopropyl betaine and laureth sulfuric ester ammonium, coconut oleoyl amine
MEA sodium cocoyl glycinate/myristamide propyl pg dimonium chloride phosphate compatibility can significantly improve the soft of shampoo
Soft low-temperature stability.
Sodium cocoyl glycinate is amino acid surfactant, can significantly change surface tension of liquid, amino acid surface
Activating agent thickening in distress is not easy the problems such as stable, foam is not abundant enough.But since the surfactant of other classes exists, so that
Shampoo has ideal viscosity and foam abundant.
Further, the preservative in parts by weight includes: 0.15-0.25 parts of Climbazole, DMDM hydantoin
0.2-0.4 parts and methylchloroisothiazandnone 0.3-0.6 parts.These three antiseptic and inhibiting bacteria function agent use simultaneously, in the less feelings of dosage
It can reach good fungistatic effect under condition, relative to single preservative is used, this Determination of Preservatives, which is used in combination, to be improved
Fungistatic effect and wider scope of restraining fungi.
These three are further, further include 0.6-1 parts of suspension stabilizer in parts by weight in shampoo formula, described outstanding
Floating stabilizer is two (hydrogenated-tallow group) phthalic acid acyls.The suspension stabilizer is to wash shield class to commonly use, and has good suspension
Stablizing effect.
Further, the formula of shampoo in parts by weight are as follows:
55-62 parts of water, 2.5-3.5 parts of dimethyl silicone polymer, 2.2-2.6 parts of ethylene glycol stearate, lauroyl flesh ammonia
Sour sodium 1.4-1.8 parts, it is 0.15-0.25 parts of Polyquaternium-10,0.4-0.6 parts of cetostearyl alcohol, 0.2-0.4 parts of ammonium chloride, sincere
0.05-0.15 parts of this vaccinium ashei extract, 1-3 parts of celery seed extract, 1-3 parts of silk hydroiyzing liquid, zinc pyrithione 0.08-
0.12 part, 0.04-0.06 parts of piroctone olamine salt, 0.08-0.12 parts of EDETATE SODIUM, laureth sulfuric ester ammonium 13-
17 parts, 2.5-3 parts of coconut oleoyl amine MEA, 1.5-2.5 parts of lauroylamidopropyl betaine, 1-1.5 parts of sodium cocoyl glycinate, meat
.8-1.2 parts of cardamom amido propyl pg dimonium chloride phosphoesterase 30,0.15-0.25 parts of Climbazole, DMDM hydantoin
0.2-0.4 parts, 0.3-0.6 parts of methylchloroisothiazandnone, two 0.6-1 parts of (hydrogenated-tallow group) phthalic acid acyls, sweet wormwood mention
Take 0.5 part of object, 0.5-1 parts of rosemary water.
Further, the formula of shampoo in parts by weight are as follows:
57.75-61.75 parts of water, 15 parts of laureth sulfuric ester ammonium, 3 parts of dimethyl silicone polymer, coconut oleoyl amine MEA
2.8 parts, 2.4 parts of ethylene glycol stearate, 2 parts of lauroylamidopropyl betaine, 1.6 parts of sodium lauroyl sarcosine, cocounut oil acyl it is sweet
1.3 parts of propylhomoserin sodium, two 0.8 part of (hydrogenated-tallow group) phthalic acid amides, 0.2 part of Polyquaternium-10, cetostearyl alcohol 0.5
Part, 0.3 part of ammonium chloride, 0.1 part of great bilberry fruit extracts, 1-3 parts of celery seed extract, myristamide propyl PG- bis-
1 part of ammonio methacrylate phosphate, 1-3 parts of silk hydroiyzing liquid, 0.1 part of zinc pyrithione, 0.2 part of Climbazole, piroctone ethyl alcohol
0.05 part of amine salt, 0.1 part of EDETATE SODIUM, 0.3 part of DMDM hydantoin, 0.5 part of methylchloroisothiazandnone, Artemisinin
0.5 part, 0.8 part of rosemary water.
The preparation process of above-mentioned dandruff control shampoo containing, comprising the following steps:
(1), water and EDETATE SODIUM are added to the container stirring and dissolving according to formula ratio；
(2) laureth sulfuric ester ammonium, poly dimethyl silicon are sequentially added according to formula ratio in the liquid in step (1)
Oxygen alkane, coconut oleoyl amine MEA, ethylene glycol stearate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, the sweet ammonia of cocounut oil acyl
Sour sodium, two (hydrogenated-tallow group) phthalic acid amides, Polyquaternium-10, cetostearyl alcohol, ammonium chloride and celery (APIUM
GRAVEOLENS) seed extract stirs evenly；
(3), Climbazole, piroctone olamine are sequentially added according to formula ratio into mixture made from step (2)
Salt, DMDM hydantoin, methylchloroisothiazandnone, stirring are complete to dissolving；
(4), great bilberry fruit extracts, Pork and beans are sequentially added according to formula ratio into mixture made from step (3)
Cool amido propyl pg dimonium chloride phosphate, silk hydroiyzing liquid and zinc pyrithione stir evenly up to the anti-dandruff shampoo
Water.
Above-mentioned step of preparation process is simple to operation, by surfactant and preservative respectively in step (4) and (3)
It is added, preservative is sufficiently mixed uniformly with main component, most surfaces activating agent is added in final step and controls
Speed of agitator is reduced while surfactant and other compositions are sufficiently mixed uniform and is foamed.
Further, in step (4), the pH of shampoo is 5.5-6.5, viscosity 5000-6000cP.
Further, step (1)-(4) carry out at normal temperature, so that simple process is easy to operate, moreover it is possible to keep each ingredient
Stability of molecule.
Below by way of specific embodiment, the present invention is further explained.
Embodiment 1-5
The preparation process of the dandruff control shampoo containing for improving scalp epidermis microbial flora of the present embodiment group is as follows:
(1) water and EDETATE SODIUM are added to the container stirring and dissolving according to formula ratio；
(2) laureth sulfuric ester ammonium, poly dimethyl silicon are sequentially added according to formula ratio in the liquid in step (1)
Oxygen alkane, coconut oleoyl amine MEA, ethylene glycol stearate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, the sweet ammonia of cocounut oil acyl
Sour sodium, two (hydrogenated-tallow group) phthalic acid amides, Polyquaternium-10, cetostearyl alcohol, ammonium chloride and celery (APIUM
GRAVEOLENS) seed extract stirs evenly；
(3), Climbazole, piroctone olamine are sequentially added according to formula ratio into mixture made from step (2)
Salt, DMDM hydantoin, methylchloroisothiazandnone, stirring are complete to dissolving；
(4), great bilberry fruit extracts, Pork and beans are sequentially added according to formula ratio into mixture made from step (3)
Cool amido propyl pg dimonium chloride phosphate, silk hydroiyzing liquid, zinc pyrithione, Artemisinin and rosemary water, stirring
Uniformly up to the dandruff control shampoo containing, the pH of shampoo is 5.5-6.5, viscosity 5000-6000Pas.Step (1)-(4) exist
It is carried out under room temperature.
The formula of the dandruff control shampoo containing of embodiment 1-5 in parts by weight is as shown in the table.
Myristamide propyl pg dimonium chloride phosphate can enhance the fungistatic effect of zinc pyrithione.It will be commercially available
Shampoo (shampoo), the commercially available zinc pyrithione for containing 2% weight percent and the present invention while there is myristamide propyl PG-
Alkyl dimethyl ammonium chloride phosphate and the shampoo of zinc pyrithione carry out the minimum inhibitory concentration test to chlosma saccharomycete, knot
Fruit is as shown in Figure 1, it is seen then that contains 1% weight percent myristamide propyl pg dimonium chloride phosphate and 1% weight
The shampoo for measuring percentage zinc pyrithione has the smallest Mlc, it was demonstrated that myristamide propyl pg dimonium chloride
Phosphate can enhance the fungistatic effect of zinc pyrithione.
The shampoo of 1-5 of the embodiment of the present invention is tested, 15 people of oiliness scalp testee, oiliness scalp contrast groups 15
People, 15 people of dry scalp testee, 15 people of dry scalp contrast groups, all testees have the scalps such as dandruff and itch to ask
Topic.Testee is washed hair weekly 3 times using the shampoo of the embodiment of the present invention 2, and contrast groups are washed hair using placebo, 3 times a week, 3
Collecting effect after week, as shown in Figure 2, it is seen then that shampoo of the invention has antidandruff, scalp of releiving to different types of scalp
Effect and antipruritic, in Fig. 2 a and Fig. 2 b, outer wire is using the different feeling accounting of the testee of shampoo of the present invention, interior wire
It is the different feeling accounting using the testee of placebo.The ingredient of placebo and the ingredient of shampoo of the present invention are essentially identical,
The difference is that without the myristamide propyl pg dimonium chloride phosphate in the present invention, zinc pyrithione, celery
Seed extract, silk hydroiyzing liquid, Artemisinin and rosemary water.
Oiliness scalp testee and dry scalp testee are during using shampoo of the present invention to itching of the scalp degree
Marking is as shown in table 3, it is seen that either oiliness scalp or dry scalp, shampoo of the invention can make two kinds of itching of the scalps
Sense is significant to mitigate.Scalp spot adhesive tape sample is tested, histamine releasing reduces by 46%, p < 0.01；It is tested to oiliness scalp
Person carries out the detection of fat secretion amount, reduces 27%-47% using oil quantity after shampoo of the present invention 7 days, uses grease after 21 days
Secretory volume reduces 34.3%-61%；On all types scalp, scalp wettability increases 12%-148%, water loss amount drop
Low 6.9%-36%, it is seen then that scalp can restore optimal moisten and cross, and the fat secretion amount of oiliness scalp is also reduced.
Oiliness scalp testee and dry scalp testee are during using shampoo of the present invention to dandruff size and head
The marking of bits degree as shown in table 4, and carries out microshot to scalp, and photo is as shown in figure 5, using shampoo of the present invention after 21 days
Scalp application confocal laser microscopic evaluation, cuticle thickness reduce 13%-47%.Hair washing water energy of the invention substantially reduces
Dandruff limits the tendency of epidermal hyper-proliferative relevant to dandruff is generated.
Celery seed extract in the shampoo of the embodiment of the present invention 2 is subjected to testing in vitro.3% weight percent will be contained
The solution of celery seed extract apply by Malassezia furfur and Malassezia cilobosa stress skin explant on, class
Toll receptor 9 (TLR-9, horse traction color Salmonella receptor) reduces 16%.Solution containing 3% weight percent celery seed extract is answered
Used in by the horse traction color Salmonella irritation fatty acid mixt of horse traction color Salmonella metabolite (imitative) stress Human Keratinocytes
On, IL-8 reduces 65%/PGE2 and reduces 83%, β-defensin, 2 antibody (antibacterial peptide) increase by 118%.3% weight hundred will be contained
The solution than celery seed extract is divided to apply on human sebum's gland cell, lipid production quantity reduces 40%.As it can be seen that celery seed mentions
Take object that can neutralize irritation caused by scalp flora.
About reparation scalp epidermis intact: the solution containing 3% weight percent celery seed extract is applied at human body angle
Change on cell, involurin increases by 135%, and loricrin increases by 29.8%, and silk polyprotein increases by 91%；Neutral lipid increases
10.5%, cholesterol increases by 107% by positive regulation, Cer NS.It, can positive regulation about terminal epidermal differentiation
Cornulin protein expression；About furfur, it is adjustable KLK and SPINK5 protein expression.As it can be seen that celery seed extract is adjustable table
The process of skin differentiation and furfur.
Comparative example 1
The shampoo of this comparative example is substantially the same manner as Example 2, the difference is that, it is free of in the shampoo of this comparative example
There is celery seed extract.One group of tested crowd totally 15 people separately is set, is washed hair using the shampoo of this comparative example, 3 times a week, after 3 weeks
Collecting effect: 10 people's itch mitigate, 9 people mitigate without dandruff, 6 numbers of people bits, using commercially available routine without after dandruff control shampoo containing one month,
The bits recurrence of 5 numbers of people.
Comparative example 2
The shampoo of this comparative example is substantially the same manner as Example 2, the difference is that, the shampoo of this comparative example does not contain
Myristamide propyl pg dimonium chloride phosphate and zinc pyrithione.One group of tested crowd totally 15 people separately is set, it is right using this
The shampoo of ratio is washed hair, and 3 times a week, collecting effect after 3 weeks: 12 people's itch mitigate, 7 people mitigate without dandruff, 8 numbers of people bits, adopt
After this comparative example one month, 15 people's itch mitigate, 14 people mitigate without dandruff, 1 number of people bits, using commercially available routine without anti-dandruff shampoo
After water one month, no dandruff recurrence.
The technical principle of the invention is described above in combination with a specific embodiment.These descriptions are intended merely to explain of the invention
Principle, and shall not be construed in any way as a limitation of the scope of protection of the invention.Based on the explanation herein, the technology of this field
Personnel can associate with other specific embodiments of the invention without creative labor, these modes are fallen within
Within protection scope of the present invention.
Claims (10)
1. the dandruff control shampoo containing that one kind can improve scalp epidermis microbial flora, which is characterized in that its raw material in parts by weight
Include:
55-62 parts of water, 2.5-3.5 parts of dimethyl silicone polymer, 2.2-2.6 parts of ethylene glycol stearate, sodium lauroyl sarcosine
1.4-1.8 parts, 0.15-0.25 parts of Polyquaternium-10,0.4-0.6 parts of cetostearyl alcohol, 0.2-0.4 parts of ammonium chloride, bog bilberry get over
0.05-0.15 parts of tangerine fruit extracts, 1-3 parts of celery seed extract, 1-3 parts of silk hydroiyzing liquid, zinc pyrithione 0.08-0.12
Part, 0.04-0.06 parts of piroctone olamine salt, 0.08-0.12 parts of EDETATE SODIUM, 18.8-25.2 parts of surfactant and anti-
Rotten agent 0.65-1.25 parts.
2. the dandruff control shampoo containing according to claim 1 for improving scalp epidermis microbial flora, which is characterized in that described
Its raw material in parts by weight of dandruff control shampoo containing further include: 0.5 part and 0.5-1 parts of rosemary water of Artemisinin.
3. the dandruff control shampoo containing according to claim 1 for improving scalp epidermis microbial flora, which is characterized in that described
Surfactant is selected from cationic surfactant, anion active agent, nonionic surface active agent, amphoteric surfactant
With one of amino acid surfactant or a variety of.
4. the dandruff control shampoo containing according to claim 3 for improving scalp epidermis microbial flora, which is characterized in that with weight
The surfactant for measuring part meter includes: 13-17 parts of laureth sulfuric ester ammonium, 2.5-3 parts of coconut oleoyl amine MEA, laurel
1.5-2.5 parts of amido propyl betaine, 1-1.5 parts of sodium cocoyl glycinate and myristamide propyl pg dimonium chloride
.8-1.2 parts of phosphoesterase 30.
5. the dandruff control shampoo containing according to claim 1 for improving scalp epidermis microbial flora, which is characterized in that with weight
The preservative for measuring part meter includes: 0.15-0.25 parts of Climbazole, 0.2-0.4 parts of DMDM hydantoin and the different thiophene of methyl chloride
0.3-0.6 parts of oxazoline ketone.
6. the dandruff control shampoo containing according to claim 1 for improving scalp epidermis microbial flora, which is characterized in that described
It further include 0.6-1 parts of suspension stabilizer in parts by weight in shampoo formula, the suspension stabilizer is two (hydrogenated tallows
Base) phthalic acid acyl.
7. the dandruff control shampoo containing according to claim 1-6 for improving scalp epidermis microbial flora, feature
It is, the formula of the shampoo in parts by weight are as follows:
55-62 parts of water, 2.5-3.5 parts of dimethyl silicone polymer, 2.2-2.6 parts of ethylene glycol stearate, sodium lauroyl sarcosine
1.4-1.8 parts, 0.15-0.25 parts of Polyquaternium-10,0.4-0.6 parts of cetostearyl alcohol, 0.2-0.4 parts of ammonium chloride, bog bilberry get over
0.05-0.15 parts of tangerine fruit extracts, 1-3 parts of celery seed extract, 1-3 parts of silk hydroiyzing liquid, zinc pyrithione 0.08-0.12
Part, 0.04-0.06 parts of piroctone olamine salt, 0.08-0.12 parts of EDETATE SODIUM, 13-17 parts of laureth sulfuric ester ammonium,
2.5-3 parts of coconut oleoyl amine MEA, 1.5-2.5 parts of lauroylamidopropyl betaine, 1-1.5 parts of sodium cocoyl glycinate, nutmeg
.8-1.2 parts of amido propyl pg dimonium chloride phosphoesterase 30,0.15-0.25 parts of Climbazole, DMDM hydantoin 0.2-
0.4 part, 0.3-0.6 parts of methylchloroisothiazandnone, two 0.6-1 parts of (hydrogenated-tallow group) phthalic acid acyls, Artemisinin
0.5 part and 0.5-1 parts of rosemary water.
8. the dandruff control shampoo containing according to claim 7 for improving scalp epidermis microbial flora, which is characterized in that described
The formula of shampoo in parts by weight are as follows:
57.75-61.75 parts of water, 15 parts of laureth sulfuric ester ammonium, 3 parts of dimethyl silicone polymer, coconut oleoyl amine MEA 2.8
Part, 2.4 parts of ethylene glycol stearate, 2 parts of lauroylamidopropyl betaine, 1.6 parts of sodium lauroyl sarcosine, cocounut oil acyl glycine
1.3 parts of sodium, two 0.8 part of (hydrogenated-tallow group) phthalic acid amides, 0.2 part of Polyquaternium-10,0.5 part of cetostearyl alcohol,
0.3 part of ammonium chloride, 0.1 part of great bilberry fruit extracts, 1-3 parts of celery seed extract, myristamide propyl PG- dimethyl
1 part of ammonium chloride phosphate, 1-3 parts of silk hydroiyzing liquid, 0.1 part of zinc pyrithione, 0.2 part of Climbazole, piroctone olamine salt
0.05 part, 0.1 part of EDETATE SODIUM, 0.3 part of DMDM hydantoin, 0.5 part of methylchloroisothiazandnone, 0.5 part of Artemisinin
With 0.8 part of rosemary water.
9. the preparation process of dandruff control shampoo containing according to claim 7, which comprises the following steps:
(1), water and EDETATE SODIUM are added to the container stirring and dissolving according to formula ratio；
(2) laureth sulfuric ester ammonium, polydimethylsiloxanes are sequentially added according to formula ratio in the liquid in step (1)
Alkane, coconut oleoyl amine MEA, ethylene glycol stearate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, cocounut oil acyl glycine
Sodium, two (hydrogenated-tallow group) phthalic acid amides, Polyquaternium-10, the pure and mild ammonium chloride of cetearyl alcohol and celery seed extract,
It stirs evenly；
(3), into mixture made from step (2) according to formula ratio sequentially add Climbazole, piroctone olamine salt,
DMDM hydantoin and methylchloroisothiazandnone, stirring are complete to dissolving；
(4), great bilberry fruit extracts, myristoyl are sequentially added according to formula ratio into mixture made from step (3)
Amine propyl pg dimonium chloride phosphate, silk hydroiyzing liquid, zinc pyrithione, Artemisinin and rosemary water, stir evenly
Up to the dandruff control shampoo containing.
10. the preparation process of dandruff control shampoo containing according to claim 7, which is characterized in that described in the step (4)
The pH of shampoo is 5.5-6.5, viscosity 5000-6000cP.
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| CN110755329A (en) * | 2019-12-03 | 2020-02-07 | 扬州澳博日化有限公司 | Washing and protecting product containing novel surfactant and manufacturing process |
| CN110772435A (en) * | 2019-11-20 | 2020-02-11 | 曼真实业(广州)有限公司 | Anti-dandruff shampoo and preparation method thereof |
| CN110806408A (en) * | 2019-11-14 | 2020-02-18 | 珠海伊斯佳科技股份有限公司 | Method for detecting malassezia scalp |
| CN111407683A (en) * | 2020-03-27 | 2020-07-14 | 广州澳希亚实业有限公司 | Scalp micro-ecological nursing composition and preparation method and application thereof |
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| CN113018246A (en) * | 2021-03-16 | 2021-06-25 | 广东格物生物科技有限公司 | Probiotic shampoo capable of relieving scalp inflammation and preparation method thereof |
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| CN113476357B (en) * | 2021-06-17 | 2023-12-29 | 广东菁萃生物科技有限公司 | Antibacterial antiallergic natural anti-dandruff shampoo and preparation method thereof |
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| CN114306146A (en) * | 2022-01-13 | 2022-04-12 | 拉芳家化股份有限公司 | Shampoo containing combination of anti-dandruff and anti-hair loss active ingredients |
| CN114522130A (en) * | 2022-03-10 | 2022-05-24 | 上海寰球实业发展有限公司 | Composition with anti-dandruff effect and preparation method thereof |
| CN116602890B (en) * | 2023-05-31 | 2024-02-09 | 广州家化化学有限公司 | Anti-dandruff shampoo containing nano-gold and preparation method thereof |
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Application publication date: 20191015 |