CN113041184A - Shampoo and preparation method thereof - Google Patents

Abstract

The application relates to the field of daily necessities, in particular to shampoo and a preparation method thereof. The shampoo mainly comprises the following raw materials in percentage by mass: 0.2 to 1.4 percent of capryloyl glycine, 0.0225 to 0.0675 percent of sericin, 0.1 to 3 percent of celery seed extract, 0.05 to 1 percent of piroctone olamine salt and 0.1 to 2 percent of sugar alcohol; wherein the sugar alcohol comprises xylitol and lactitol. The shampoo can balance bacterial colony by mutual compatibility of caprylyl glycine, sericin, celery seed extract, piroctone olamine salt and sugar alcohol, reduce dandruff and avoid more dandruff. And simultaneously provides corresponding nutrition for the hair to avoid cuticle shedding.

Description

Shampoo and preparation method thereof

Technical Field

The application relates to the field of daily necessities, in particular to shampoo and a preparation method thereof.

Background

Dandruff is a phenomenon of extensive desquamation caused by excessive proliferation of scalp keratinocytes and is characterized by an abnormal increase in macroscopic flaky white scales or scales, which may be accompanied by itching. Skin desquamation is often difficult to observe visually, and when large amounts of scale accumulate, visible dandruff appears.

The present application aims to provide a shampoo capable of inhibiting the growth of dandruff.

Disclosure of Invention

An object of the embodiments of the present application is to provide a shampoo and a method for preparing the same, which aim to provide a shampoo capable of inhibiting the growth of dandruff.

The application provides shampoo, and the raw materials of the shampoo mainly comprise the following components in percentage by mass:

0.2 to 1.4 percent of capryloyl glycine, 0.0225 to 0.0675 percent of sericin, 0.1 to 3 percent of celery seed extract, 0.05 to 1 percent of piroctone olamine salt and 0.1 to 2 percent of sugar alcohol;

wherein the sugar alcohol comprises xylitol and lactitol.

In some embodiments of the present application, the shampoo comprises the following components in percentage by mass:

0.3-0.5% of capryloyl glycine, 0.03-0.04% of silk fibroin, 1-1.5% of celery seed extract, 0.3-0.5% of piroctone olamine salt and 0.5-1% of sugar alcohol.

In some embodiments of the present application, the shampoo raw materials further comprise the following components in percentage by mass:

creatine 0.5-1%, panthenol 0.2-0.5%.

In some embodiments of the present application, SERICIN is selected from a material available from Bioland under the trade name SERICIN 4.5%.

In some embodiments herein, the sugar alcohol is selected from the materials provided by the manufacturer for sederma under the trade name HAIRSPA.

In some embodiments of the present application, the shampoo stock further comprises at least one of a polyol humectant, a cationic conditioning agent, a rheology modifier, an ester-forming agent, a thickener, a fragrance, a preservative, a pH adjuster, and a skin conditioning agent.

In some embodiments of the present application, the shampoo stock further comprises from 10% to 45% of a surfactant;

the surfactant comprises at least one of a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant and an anionic surfactant;

optionally, the nonionic surfactant is selected from at least one of lauryl glucoside, decyl glucoside, octyl/decyl glucoside, coco glucoside, PEG-80 sorbitan monolaurate, and laureth-7 citrate;

optionally, the amphoteric surfactant is selected from at least one of sodium lauroamphoacetate, sodium cocoamphoacetate, cocamidopropyl betaine, lauramidopropyl betaine, cocobetaine, mink oil amidopropyl betaine, cocamidopropyl hydroxysultaine, disodium lauroamphodiacetate, disodium cocoamphodiacetate, lauramidopropyl amine oxide, and cocamidopropyl amine oxide;

optionally, the amino acid surfactant is selected from at least one of sodium cocoyl malate, sodium lauroyl avenaminate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium cocoyl glutamate, sodium lauroyl glutamate, disodium cocoyl glutamate, disodium lauroyl glutamate, sodium methyl stearoyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium stearoyl glutamate, sodium cocoyl aminopropionate, TEA cocoyl glutamate, lauroyl glutamate, and cocoyl glutamate;

optionally, the anionic surfactant is selected from at least one of sodium lauryl glucose carboxylate, disodium coco-glucoside citrate, sodium cocoyl isethionate, sodium coco polyether sulfate, sodium laureth-13 carboxylate, sodium laureth-3 carboxylate, disodium laureth sulfosuccinate, sodium laureth sulfoacetate, sodium laureth sulfate, and ammonium laureth sulfate.

The application also provides a preparation method of the shampoo, which mainly comprises the following steps:

dissolving and mixing the capryloyl glycine and the piroctone olamine salt at 68-72 ℃ to obtain a mixed solution, then cooling the mixed solution to 42-45 ℃, adding the celery seed extract, the sericin and the sugar alcohol, uniformly mixing, then cooling to 37-39 ℃, and filtering to obtain a filtrate.

In some embodiments of the present application, mixing the octanoylglycine with the piroctone olamine salt further comprises:

dissolving and mixing a polyol humectant, a cationic conditioner, a surfactant, a rheology modifier, an ester forming agent and a thickening agent at 80-85 ℃, then cooling to 68-72 ℃, and adding the caprylyl glycine and the piroctone olamine salt.

In some embodiments of the present application, the pH of the shampoo is adjusted to 5.5 to 6.5 using a pH adjuster.

The shampoo and the preparation method thereof have the beneficial effects that:

the shampoo can balance bacterial colony by mutual compatibility of caprylyl glycine, sericin, celery seed extract, piroctone olamine salt and sugar alcohol, reduce dandruff and avoid more dandruff. And simultaneously provides corresponding nutrition for the hair to avoid cuticle shedding.

The anti-dandruff shampoo provided by the application achieves the purpose of regulating scalp flora by inhibiting the propagation of scalp flora, and can reduce the number of dandruff and reduce scalp pruritus within a certain time by regulating the epidermis differentiation and the epidermis integrity of scalp in the desquamation process; the shampoo can be added with no silicone oil, and has effects of keeping moisture, nourishing scalp and balancing oil secretion, and reducing tendency of excessive proliferation of scalp keratinocyte to cause massive desquamation. In addition, the formula can reconstruct the hair structure from the inside, strengthen the hair quality and reduce the phenomena of frizziness, split and fracture of the hair.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.

Fig. 1 shows the results of the bacteriostatic test provided in test example 6.

Fig. 2 shows the results of the rate of scalp moisture loss provided by test example 7.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The pathogenesis of dandruff is not yet clear, and there are several indications as to the cause of dandruff: microbial colonization (fungal colonization and bacterial colonization), increased sebaceous gland activity, individual susceptibility (including epidermal barrier integrity, genetic factors, neurogenic and emotional stress, immune factors, nutrition and other factors), skin disease, and the like.

Skin microbial studies have shown that malassezia, which is a unicellular fungus belonging to the saccharomyces genus and survives through the consumption of fatty acids in sebum, is considered as a key factor causing the aggravation of dandruff. It is lipid-dependent and tends to grow on sebum-rich skin. The mechanism of action of malassezia in the etiology of dandruff formation is: malassezia on the scalp decomposes triglycerides present in sebum by active phospholipases and lipases to release unsaturated fatty acids such as arachidonic acid and oleic acid, which in turn affect scalp integrity, impair epidermal barrier function, cause immune stimulation, induce inflammatory reactions, and cause keratinocytes to produce inflammatory cytokines such as IL-1, IL-6, IL-8, and TNF- α. Arachidonic acid synthesizes prostaglandins which prolong the response time of inflammation by inducing neutrophil aggregation and vasodilation, while metabolites can further worsen the bad condition of scalp, cause abnormal differentiation of keratinocytes, interfere with keratinization, and further cause abnormal proliferative changes such as parakeratosis, intracellular lipid droplets, desmosome reduction, and intercellular lipid increase. Recent studies have found that beta-carbonic anhydrase in malassezia can cause an imbalance of normal bacterial fungi of the skin, leading to dandruff production, and that inhibitors of this enzyme are effective in relieving dandruff and seborrheic dermatitis.

In addition, bacterial infections can also lead to increased dandruff, and the relationship between bacteria and dandruff is stronger than that between fungi and dandruff. Another research shows that the propionibacterium and the staphylococcus epidermidis can mutually inhibit, and the propionibacterium can inhibit the growth of the staphylococcus epidermidis by secreting bacteriocin; whereas staphylococcus epidermidis can inhibit excessive reproduction of propionibacteria by metabolizing glycerol. Microbiology studies found that the number of propionibacteria in the dandruff zone was significantly reduced and the number of staphylococcus epidermidis increased compared to normal scalp, indicating that the balance of the two affects the severity of dandruff. Currently, common antidandruff agents on the market are salicylic acid, Zinc Pyrithione (also known as Zinc Pyrithione, Pyrithione Zinc, abbreviated as ZPT), Piroctone olamine (trade name Octopirox, abbreviated as OCT), Climbazole (Climbazole, trade name Climbazole, abbreviated as CLM), and the like.

Salicylic acid has no significant antifungal effect and achieves dandruff removal by desquamation of damaged epidermal cells in the stratum corneum; the skin care product has strong irritation, the effect is not superior to other anti-dandruff products, the epidermis structure can be damaged after long-term application, the self balance of the epidermis is disturbed, certain damage is caused to the skin, and skin allergy and pruritus can be caused after long-term use. Zinc Pyrithione (ZPT) has certain toxicity and irritation, and has certain safety risk. The piroctone olamine salt can fundamentally block external factors generated by dandruff through methods of sterilization, bacteriostasis, antioxidation, oxide decomposition and the like, can effectively radically cure dandruff, can stop scalp itching, has low irritation, and cannot cause alopecia or hair breakage. However, the antidandruff effect of piroctone olamine is weaker than that of zinc pyrithione, and the aqueous solution thereof is colored, so that the product is colored, and the cost thereof is high, thus being limited in use. The climbazole can eliminate the external factors generating dandruff through sterilization and bacteriostasis to achieve the effects of removing dandruff and relieving itching, but the difference of the effects of removing dandruff and relieving itching is larger than that of ZPT and Octopirox. The present application provides a shampoo.

Hereinafter, shampoos and methods for preparing the same according to examples of the present application will be described in detail.

A shampoo is prepared from the following raw materials in percentage by mass:

0.2 to 1.4 percent of capryloyl glycine, 0.0225 to 0.0675 percent of sericin, 0.1 to 3 percent of celery seed extract, 0.05 to 1 percent of piroctone olamine salt and 0.1 to 2 percent of sugar alcohol; wherein the sugar alcohol comprises xylitol and lactitol.

In the examples of the application, caprylyl glycine, celery seed extract, sugar alcohol and caprylyl glycine interact to achieve the function of balancing flora, so that excessive propionibacterium and staphylococcus epidermidis are avoided, and excessive dandruff caused by flora imbalance is avoided. The silk sericin can be used as hair nutrient to prevent hair from breaking, and the nutrient can nourish hair root to prevent excessive cuticle.

In the present application, the caprylyl glycine content in the shampoo raw material is 0.2 to 1.4% by mass, and may be, for example, 0.2%, 0.5%, 0.8%, 1%, 1.1%, 1.3%, 1.4%, or the like.

In this example, capryloyl glycine was prepared using the material sold under the trade name LIPACIDE C8G from the manufacturer SEPPIC.

The weight fraction of sericin in the raw material of the shampoo is 0.0225-0.0675%, and may be 0.0225%, 0.03%, 0.04%, 0.05%, 0.06%, or 0.0675%, for example.

In this example, a stock available from Bioland under the trade name SERICIN 4.5% was used as SERICIN by the manufacturer. Further, 4.5% fibroin was included in 4.5% of the raw material supplied by the manufacturer to Bioland under the trade name SERICIN. Therefore, the mass fraction of the material with 4.5 percent of SERICIN in the raw material can be 0.5 to 1.5 percent.

In the present application, the celery seed extract is contained in the shampoo in an amount of 0.1 to 3% by mass, for example, 0.1%, 0.3%, 0.5%, 0.8%, 1%, 1.1% or 1.3% by mass.

In this example, celery seed extract was obtained from sederma under the trade name apischal.

In the present application, the mass fraction of the piroctone olamine salt in the starting material of the shampoo is 0.05 to 1%, and may be, for example, 0.05%, 0.06%, 0.1%, 0.2%, 0.3%, 0.4%, 0.7%, 0.9%, or 1%, and the like.

In the application, the mass fraction of sugar alcohol in the raw materials of the shampoo is 0.1-2%; for example, it may be 0.1%, 0.3%, 0.5%, 0.8%, 1%, 1.1%, 1.3%, 1.5%, 1.9%, 2%, etc. Sugar alcohols include xylitol and lactitol; in the examples of the present application, the mass ratio of xylitol and lactitol may be any ratio, such as 1:1, 2:1, 3:2, 5:4, and the like.

In this example, the sugar alcohol is selected from the group consisting of the materials sold under the trade name HAIRSPA by the manufacturer sederma, and the mass fraction of HAIRSPA is 0.1-2%. The material contained xylitol and lactitol.

In other embodiments of the present application, the raw materials may be provided by other manufacturers, and are not limited to the above sources.

Further, in some embodiments herein, the shampoo stock further comprises creatine 0.5-1% and panthenol 0.2-0.5%. The creatine and panthenol can enhance mechanical resistance of hair and reduce hair breakage.

For example, the creatine may be present in the shampoo starting material at 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1% by mass, and so forth.

The mass fraction of panthenol in the raw materials of the shampoo may be 0.2%, 0.3%, 0.4%, or 0.5%, etc.

In some embodiments, the shampoo compositions further comprise ingredients, such as 10-45% surfactant.

The surfactant comprises at least one of a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant and an anionic surfactant.

For example, the nonionic surfactant is selected from at least one of lauryl glucoside, decyl glucoside, octyl/decyl glucoside, coco glucoside, PEG-80 sorbitan monolaurate, and laureth-7 citrate.

Illustratively, the amphoteric surfactant is selected from at least one of sodium lauroamphoacetate, sodium cocoamphoacetate, cocamidopropyl betaine, lauramidopropyl betaine, cocobetaine, mink oil amidopropyl betaine, cocamidopropyl hydroxysultaine, disodium lauroamphodiacetate, disodium cocoamphodiacetate, lauramidopropyl amine oxide, and cocamidopropyl amine oxide.

Illustratively, the amino acid surfactant is selected from at least one of sodium cocoyl malate, sodium lauroyl avenamate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium cocoyl glutamate, sodium lauroyl glutamate, disodium cocoyl glutamate, disodium lauroyl glutamate, sodium methyl stearoyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium stearoyl glutamate, sodium cocoyl aminopropionate, TEA cocoyl glutamate, lauroyl glutamate, and cocoyl glutamate.

Illustratively, the anionic surfactant is selected from at least one of sodium lauryl glucose carboxylate, disodium coco-glucoside citrate, sodium cocoyl isethionate, sodium coco polyether sulfate, sodium laureth-13 carboxylate, sodium laureth-3 carboxylate, disodium laureth sulfosuccinate, sodium laureth sulfoacetate, sodium laureth sulfate, and ammonium laureth sulfate.

In some embodiments, the shampoo base further comprises at least one of a polyol humectant, a cationic conditioning agent, a rheology modifier, an ester former, a thickener, a fragrance, a preservative, a pH adjuster, and a skin conditioning agent.

Accordingly, the kinds and amounts of the polyhydric alcohol moisturizer, the cationic conditioner, the surfactant, the rheology modifier, the ester-forming agent, the thickener, the essence, the preservative, the pH adjuster, the skin conditioner, and the like can be selected according to actual needs.

As an example, SymRelief 100 from Dekisz, Apiscal from sederma, and the like may be used as skin conditioning agents.

The shampoo provided by the embodiment of the application has at least the following advantages:

the shampoo can balance flora, reduce dandruff and avoid dandruff by mutual compatibility of caprylyl glycine, sericin, celery seed extract, piroctone olamine salt and sugar alcohol. And simultaneously provides corresponding nutrition for the hair to avoid cuticle shedding.

The anti-dandruff shampoo provided by the application achieves the purpose of regulating scalp flora by inhibiting the propagation of scalp flora, and can reduce the number of dandruff and reduce scalp pruritus within a certain time by regulating the epidermis differentiation and the epidermis integrity of scalp in the desquamation process; the shampoo can be added with no silicone oil, and has effects of keeping moisture, nourishing scalp and balancing oil secretion, and reducing tendency of excessive proliferation of scalp keratinocyte to cause massive desquamation. In addition, the formula can reconstruct the hair structure from the inside, strengthen the hair quality and reduce the phenomena of frizziness, split and fracture of the hair.

The application also provides a preparation method of the shampoo, which mainly comprises the following steps:

dissolving and mixing the capryloyl glycine and the piroctone olamine salt at 68-72 ℃ to obtain a mixed solution, then cooling the mixed solution to 42-45 ℃, adding the celery seed extract, the sericin and the sugar alcohol, uniformly mixing at 42-45 ℃, then cooling to 37-39 ℃, and filtering to obtain a filtrate.

Adding caprylyl glycine and piroctone olamine salt at 68-72 deg.C (such as 68 deg.C, 69 deg.C, 70 deg.C, 71 deg.C, 72 deg.C), stirring to dissolve to obtain mixed solution, and cooling to 42-45 deg.C (such as 42 deg.C, 43 deg.C, 44 deg.C, 45 deg.C) to add Apii graveolens seed extract, sericin and sugar alcohol; is beneficial to the full mixing of the raw materials, then is cooled to 37-39 ℃ (for example, 37 ℃, 38 ℃, 39 ℃ and the like), and then is filtered to remove undissolved raw materials or impurities.

Further, in some other embodiments herein, the shampoo stock further comprises a polyol humectant, a cationic conditioner, a surfactant, a rheology modifier, an ester-forming agent, a thickener, and the like.

In the preparation process, the polyalcohol humectant, the cation conditioner, the surfactant, the rheology modifier, the ester forming agent and the thickener are dissolved and mixed at 80-85 ℃ (for example, 80 ℃, 81 ℃, 83 ℃, 85 ℃ and the like), then the temperature is reduced to 68-72 ℃, and the caprylyl glycine and the piroctone olamine salt are added.

Illustratively, the pH of the shampoo is adjusted to 5.5-6.5 (e.g., can be 5.5, 6, 6.2, 6.5, etc.) using a pH adjuster.

The features and properties of the present application are described in further detail below with reference to examples.

Examples 1 to 15

Examples 1 to 15 each provide a shampoo having the raw materials and the ratios of the respective raw materials shown in tables 1 and 2.

The preparation method of the shampoo comprises the following steps:

firstly, EDTA-2Na, citric acid, transparent guar gum C16-S and deionized water are stirred and heated to 85 ℃, and are stirred and dissolved uniformly to form transparent liquid. Then adding polyquaternium-7, glycerol, AES 70%, CAB 45, octyl glucoside 50%, sodium lauroamphoacetate 30%, sodium lauroyl sarcosinate 30%, creatine and thickening agent, and stirring at 85 ℃ to dissolve uniformly.

Then cooling to 70 ℃, adding piroctone olamine salt and LIPACIDE C8G, keeping the temperature, stirring and dissolving uniformly. Continuously cooling to 45 ℃, adding the rest raw materials, and uniformly stirring; adjusting the pH value to 5.5; cooling to 38 +/-1 ℃, filtering and removing filter residue.

The values in tables 1 and 2 are mass percentages. The material in tables 1 and 2, which was purchased from demi under the trade name SymRelief 100, was mainly composed of ginger extract and bisabolol.

AES 70% producer was basf;

CAB 45 manufacturer was basf;

octyl glucoside 50% of the manufacturer is changyuan camu;

30% of the manufacturer of sodium lauroamphoacetate is star industry;

30% of manufacturers of sodium lauroyl sarcosinate are David;

LIPACIDE C8 manufacturer 8G is SEPPIC;

SERICIN 4.5% of the manufacturers Bioland;

the manufacturer of Apiscalp is sederma;

the manufacturer of HAIRSPA is sederma.

The Thickener is glucimate DOE-120 Thickener supplied by the manufacturer LUBRIZOL.

The TC-ZPT manufacturer is bestowing;

CARBOPOL AQUA SF-1POLYMER is Lubrizol;

the producer of glycox HE-LQ- (SG) is David.

Comparative examples 1 to 4

Comparative examples 1 to 4 each provide a shampoo whose raw materials and proportions of the respective raw materials are shown in table 1, and the production methods of comparative examples 1 to 4 refer to the production methods of the above examples.

TABLE 1 compounding ratios of examples 1 to 6 and comparative examples 1 to 4

TABLE 2 compounding ratios of example 7 to example 15

Comparative example 5

Comparative example 5 provides a shampoo whose raw materials mainly include the following components in mass fraction:

0.1% of EDTA-2Na, 0.3% of arginine, 0.3% of transparent guar gum C16-S, 51.8% of deionized water, 70.2% of polyquaternium, 3.0% of glycerol, 10.0% of AES 70%, 6.0% of (CAB 45), 7.0% of (octyl glucoside 50%), 5.0% of (sodium lauroamphoacetate 30%), 8.0% of (sodium lauroyl sarcosinate 30%), 2.0% of (TC-ZPT 48%), 5.0% of (BocARAQPOL SF-1POLYMER), 1.5% of (glycerox HE-LQ- (SG)), 0.2% of essence, 0.6% of preservative and the balance of deionized water.

The source of the raw materials of comparative example 5 was the same as in example 1, and the shampoo of comparative example 5 was prepared by the same method as in example 1.

Test example 1

A subject: the subjects had significant dandruff, and 20 individuals of the subjects were able to match the test, with the ages of 15 in 18-30 years, 15 in 31-45 years, and 10 in 46-55 years.

The using method comprises the following steps: the shampoo provided in example 1 was applied 1 time per day for 1 week.

Spot test results: no positive reaction was observed in any of the 40 subjects, indicating that the included subjects had no irritation or allergic reaction to the product.

Human body trial test results: all the subjects complete the test, and the other subjects have no obvious adverse reaction, including phenomena of scalp, face skin irritation or redness, eye irritation symptom, alopecia and the like.

The results of the patch test and the human body trial test show that the silicon-free anti-dandruff shampoo is mild.

Test example 2

The shampoo of example 15, a commercially available shampoo of a certain type without an anti-dandruff agent, was subjected to a half-head test; trial with 60 testers (moderate or severe dandruff), performed by a professional caregiver, and evaluated by a dermatologist.

Subjects were given a shampoo without an anti-dandruff agent one week prior to the test, and were scored for dandruff one day prior to the test, using the shampoo of example 15, a commercial shampoo without an anti-dandruff agent, on each of the day of the test, day 7, day 14, day 21, day 28, day 35, and day 42; the number of days corresponding to the test trip is that day, scalp scoring is carried out; the average of the number of test subjects is shown in Table 4, and the use and evaluation are shown in Table 3. The test results are shown in table 4.

TABLE 3 test procedures and evaluation criteria

TABLE 4 test results

As can be seen from table 4: the testers who used the shampoo provided in example 15 had a 95.4% reduction in dandruff and the testers had a significant anti-dandruff effect on day 14. While the dandruff of experimenters using shampoo without antidandruff agent was reduced by 9.9%; there was no significant anti-dandruff effect.

Test example 3

The shampoo of example 15 and the shampoo provided in comparative example 5 were subjected to a half-head test; trial with 60 testers (moderate or severe dandruff), performed by a professional caregiver, and evaluated by a dermatologist.

Subjects were given a commercial shampoo without anti-dandruff agent one week prior to the test, and scored for dandruff the day before the test, half the day, day 7, day 14, day 21, day 28, day 35 and day 42 of the test with the shampoo of example 15 and half the shampoo of comparative example 5; the number of days for which the test is ticked is the day that scalp scoring is performed. The use procedures and evaluations are shown in Table 5, the average values of the plurality of test subjects are shown in Table 6, and the test results are shown in Table 6.

TABLE 5 test procedures and evaluation criteria

TABLE 6 test results

As can be seen from Table 6, the dandruff was remarkably reduced in the testers who used the shampoo of example 15 and the shampoo of comparative example 5, and both had the good anti-dandruff effect; the tester using the shampoo of example 15 showed a reduction in dandruff of 95.6%, the tester using the shampoo of comparative example 5 showed a reduction in dandruff of 68.6%, and the shampoo of example 15 had a better anti-dandruff effect; the last two weeks with shampoo without anti-dandruff agent, the increase in dandruff was only slight for the test subjects using the shampoo of example 15, whereas the increase in dandruff was more pronounced for the test subjects using the shampoo provided in comparative example 5.

Test example 4

30 moderate or severe dandruff long-hair females are hired as testers, 10 hair dyes and perms are adopted, 10 hair straightens are adopted, 10 natural (not dyed and permed) hair qualities are adopted, and 100 hairs in the middle layer of the back head and the back head of each tester are taken for testing before the test; after 4 weeks, 100 middle layer hairs on the back of the test subjects were selected and tested, and before and after the test, the hair was compared.

The test method comprises the following steps: A250N pneumatic flat push clamp and a 25x25mm rubber coated clamping surface were used in the test, which effectively avoided failure of the test specimen at the clamping surface. Approximately 50mm of the repellent tape was folded up as labels (with which the samples could be handled more simply, inserted into a jig) and attached to the end of each sample. The protective tape may also provide additional cushioning to reduce sample damage at the clamping face. The test speed of the sample is 25mm/min, and the data acquisition frequency is 100 Hz. The test results are shown in Table 7. In Table 7, blank refers to a blank test using a commercial non-dandruff type conventional shampoo.

TABLE 7200 survival (hair loss) after cycles

	Blank space	Example 15 shampoo	Comparative example 5 shampoo
				Dyeing and perming agent	35％	43％	27％
Hair straightening device	46％	61％	41％
				Nature of hair	67％	87％	66％

As can be seen from table 8: the shampoo provided by the embodiment 15 of the application is beneficial to improving the mechanical resistance of hair, improving the toughness and the strength of the hair and improving the broken hair condition.

Test example 5

40 medium or severe dandruff persons, half of both men and women, aged 20-45 were hired and tried on the shampoo provided in example 15 and the shampoo provided in comparative example 5.

The using method comprises the following steps: it is administered every two days for 4 weeks. Randomly select 20 shampoos as provided in example 15; another 20 had the shampoo provided in comparative example 5 on trial.

Subject self-assessment: a questionnaire survey mode is adopted, so that a subject can self-evaluate the quantity of dandruff on two sides, the degree of scalp itching, the quantity of scalp grease, the improvement degree of hair dryness, hair smoothness, scalp soothing and the like, and the evaluation is recorded according to 0-3 points, wherein 0 point is not improved greatly; 1 is slightly improved; 2, the improvement is obvious; complete improvement or substantial recovery in 3 points.

The test results of the shampoo provided in example 15 are shown in table 8, and the test results of the shampoo provided in comparative example 5 are shown in table 9.

Table 8 test results for shampoos provided in example 15

Table 9 test results for the shampoo provided in comparative example 5

As can be seen from the results of table 8 and table 9: the shampoo provided in example 15 has significant effects on the improvement of the amount of dandruff, the degree of itching of the scalp, the amount of oil and fat in the scalp, the dryness of the hair, the soothing of the scalp, and the like, and the effects are significantly better than those of the shampoo provided in comparative example 5.

Comparative example 6

Comparative example 6 provides a shampoo whose raw materials mainly include the following components in mass fraction:

0.1% of EDTA-2Na, 0.3% of arginine, 0.3% of transparent guar gum C16-S, 51.8% of deionized water, 70.2% of polyquaternium, 3.0% of glycerol, 10.0% of AES 70%, 6.0% of CAB 45, 7.0% of octyl glucoside 50%, 5.0% of sodium lauroamphoacetate 30%, 8.0% of sodium lauroyl sarcosinate 30%, 5.0% of CarboAQPOL UA SF-1POLYMER, 1.5% of (glycerox HE-LQ- (SG)), 0.2% of essence, 0.6% of preservative and the balance of deionized water.

The source of the raw materials of comparative example 6 was the same as example 1, and the shampoo of comparative example 6 was prepared by the same method as example 1.

Test example 6

The samples of examples 1 to 15 were tested for bacteriostatic effects of examples 1 to 15 and comparative examples 5 and 6 by the bacteriostatic loop method using comparative example 5 as a positive control and comparative example 6 as a negative control. The strain used was Malassezia furfur standard strain (Malassezia furfur ATCC 44344) and the medium used was Leeming & Notman agar medium. The results of the bacteriostatic test are shown in fig. 1.

As can be seen from the illustration of the bacteriostasis results, 48% of TC-ZPT in the comparative example 5 has better bacteriostasis effect and the bacteriostasis zone is the largest, and the bacteriostasis zones of the examples under the same dilution condition are all smaller than or close to the positive control of the comparative example 5 and are obviously larger than the negative control of the comparative example 6. The shampoo provided by the embodiment of the application has certain inhibition effect on malassezia furfur standard strains.

Test example 7

The shampoo of example 15 and the shampoo provided in comparative example 5 were subjected to a half-head test; 60 testers (moderate or severe dandruff) were employed for trial and scalp moisture loss (TEWL) was tested using a skin moisture loss tester, Tewameter TM300/MPA9, and was operated and tested by a professional caregiver.

After the test subjects washed their hair with the same commercially available shampoo without the anti-dandruff agent for 2 weeks, the TEWL average of the test subjects was recorded as the initial value; after the subjects used the shampoo of example 15 half way and the shampoo of comparative example 5 half way at a frequency of 2 days/time, respectively, and used for 4 consecutive weeks, the TEWL average of the test subjects was recorded as the final value. And comparing the change difference of the initial value and the final value, wherein the larger the difference is, the better the surface scalp barrier repair effect is. The results of the scalp moisture loss rate are shown in fig. 2.

As can be seen from fig. 2: example 15 samples had a TEWL reduction of 34.6-88.0% after 4 weeks of use, with an average TEWL reduction of 61.5%, whereas comparative example 6 had no significant change from baseline. Shampoo example 15 of the present invention is shown to significantly improve or restore the barrier function of the stratum corneum of the damaged scalp.

In combination with the above evaluation tests, it is shown that the shampoo provided by the present application can restore the scalp micro-ecosystem, reestablish the scalp micro-ecological balance, and not inhibit the fungus action alone to obtain the long-acting anti-dandruff effect which is not easy to rebound.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims (10)

1. The shampoo is characterized in that the raw materials of the shampoo mainly comprise the following components in percentage by mass:

0.2 to 1.4 percent of capryloyl glycine, 0.0225 to 0.0675 percent of sericin, 0.1 to 3 percent of celery seed extract, 0.05 to 1 percent of piroctone olamine salt and 0.1 to 2 percent of sugar alcohol;

wherein the sugar alcohol comprises xylitol and lactitol.

2. The shampoo according to claim 1, characterized in that the raw materials of the shampoo mainly comprise the following components in percentage by mass:

0.3-0.5% of capryloyl glycine, 0.03-0.04% of silk fibroin, 1-1.5% of celery seed extract, 0.3-0.5% of piroctone olamine salt and 0.5-1% of sugar alcohol.

3. The shampoo of claim 1, wherein the shampoo comprises the following ingredients in percentage by mass:

creatine 0.5-1% and panthenol 0.2-0.5%.

4. A shampoo according to any of claims 1 to 3 characterised in that the SERICIN is selected from a material supplied by Bioland under the trade name SERICIN 4.5%.

5. A shampoo as claimed in any one of claims 1 to 3 characterised in that the sugar alcohol is selected from materials supplied by the manufacturer as sederma under the trade name HAIRSPA.

6. A shampoo according to any of claims 1 to 3 wherein the shampoo ingredients further comprise at least one of a polyhydric alcohol humectant, a cationic conditioning agent, a rheology modifier, an ester former, a thickener, a perfume, a preservative, a pH adjuster, and a skin conditioning agent.

7. A shampoo as claimed in any one of claims 1 to 3 characterised in that the shampoo ingredients further comprise from 10 to 45% of a surfactant;

the surfactant comprises at least one of a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant and an anionic surfactant;

optionally, the nonionic surfactant is selected from at least one of lauryl glucoside, decyl glucoside, octyl/decyl glucoside, coco glucoside, PEG-80 sorbitan monolaurate, and laureth-7 citrate;

optionally, the amphoteric surfactant is selected from at least one of sodium lauroamphoacetate, sodium cocoamphoacetate, cocamidopropyl betaine, lauramidopropyl betaine, cocobetaine, mink oil amidopropyl betaine, cocamidopropyl hydroxysultaine, disodium lauroamphodiacetate, disodium cocoamphodiacetate, lauramidopropyl amine oxide, and cocamidopropyl amine oxide;

optionally, the amino acid surfactant is selected from at least one of sodium cocoyl malate, sodium lauroyl avenaminate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium cocoyl glutamate, sodium lauroyl glutamate, disodium cocoyl glutamate, disodium lauroyl glutamate, sodium methyl stearoyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium stearoyl glutamate, sodium cocoyl aminopropionate, TEA cocoyl glutamate, lauroyl glutamate, and cocoyl glutamate;

optionally, the anionic surfactant is selected from at least one of sodium lauryl glucose carboxylate, disodium coco-glucoside citrate, sodium cocoyl isethionate, sodium coco polyether sulfate, sodium laureth-13 carboxylate, sodium laureth-3 carboxylate, disodium laureth sulfosuccinate, sodium laureth sulfoacetate, sodium laureth sulfate, and ammonium laureth sulfate.

8. A process for the preparation of a shampoo as claimed in any of claims 1 to 7 which consists essentially of:

dissolving and mixing the capryloyl glycine and the piroctone olamine salt at 68-72 ℃ to obtain a mixed solution, then cooling the mixed solution to 42-45 ℃, adding the celery seed extract, the sericin and the sugar alcohol, uniformly mixing, then cooling to 37-39 ℃, and filtering to obtain a filtrate.

9. A method of preparing a shampoo as claimed in claim 8 characterised in that the mixing of the octanoylglycine with the piroctone olamine further comprises:

dissolving and mixing a polyol humectant, a cationic conditioner, a surfactant, a rheology modifier, an ester forming agent and a thickening agent at 80-85 ℃, then cooling to 68-72 ℃, and adding the caprylyl glycine and the piroctone olamine salt.

10. A process for the preparation of a shampoo according to claim 8,

adjusting pH of shampoo to 5.5-6.5 with pH regulator.

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