CN116602890A - Anti-dandruff shampoo containing nano-gold and preparation method thereof - Google Patents

Anti-dandruff shampoo containing nano-gold and preparation method thereof Download PDF

Info

Publication number
CN116602890A
CN116602890A CN202310635082.6A CN202310635082A CN116602890A CN 116602890 A CN116602890 A CN 116602890A CN 202310635082 A CN202310635082 A CN 202310635082A CN 116602890 A CN116602890 A CN 116602890A
Authority
CN
China
Prior art keywords
gold
nano
dandruff shampoo
parts
purchased
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202310635082.6A
Other languages
Chinese (zh)
Other versions
CN116602890B (en
Inventor
林飞武
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Jiahua Chemical Co ltd
Original Assignee
Guangzhou Jiahua Chemical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Jiahua Chemical Co ltd filed Critical Guangzhou Jiahua Chemical Co ltd
Priority to CN202310635082.6A priority Critical patent/CN116602890B/en
Publication of CN116602890A publication Critical patent/CN116602890A/en
Application granted granted Critical
Publication of CN116602890B publication Critical patent/CN116602890B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20Halogens; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/413Nanosized, i.e. having sizes below 100 nm
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The application relates to the technical field of shampoo, and in particular discloses an anti-dandruff shampoo containing nano-gold and a preparation method thereof. The anti-dandruff shampoo containing the nano-gold comprises the following components in parts by mass: 71.05-73.34 minutes of solvent; 1.98-2.1 parts of conditioner; 0.03-0.05 part of pH regulator; 1.55-1.7 parts of thickener; 0.75-0.8 part of pearling agent; 20.25-21.8 parts of surfactant; 0.35-0.4 parts of di (hydrogenated tallow) phthalic acid amide; 0.45-0.5 part of suspension stabilizer; 0.9-1.1 parts of nano gold; 0-0.5 part of essence; the thickener is the compounding of cetostearyl alcohol and sodium chloride. The application has the advantage that the antibacterial effect of the anti-dandruff shampoo containing nano-gold is better and durable and stable.

Description

Anti-dandruff shampoo containing nano-gold and preparation method thereof
Technical Field
The application relates to the field of shampoo, in particular to anti-dandruff shampoo containing nano-gold and a preparation method thereof.
Background
The shampoo is a washing and caring product for cleaning hair and scalp, and is used for cleaning hair and impurities such as grease, dust, dandruff, etc. on scalp, so as to keep hair clean.
Dandruff is keratinocyte that the scalp drops off, under normal state, keratinocyte drops off seldom, very slowly, but under some stimulations, immature keratinocyte can appear the phenomenon that numerous caking drops off, lead to the dandruff to increase.
There are various stimuli that cause dandruff, among them, the most important is the stimulus from bacteria, especially the ubiquitous malassezia, when malassezia on the scalp multiply, it is easy to cause skin superficial stratum corneum and hair follicle infection, thus make the scalp stimulated, and then cause the production of a large amount of dandruff, therefore, in numerous anti-dandruff shampoos, usually add bacteriostats, through inhibiting, eliminating harmful bacteria on the scalp, thus make the ecological environment of the scalp keep healthy, and then realize the effect of inhibiting dandruff production.
The nano gold is a good bacteriostatic agent, and the bacteriostatic effect of the shampoo can be remarkably improved by adding the nano gold into the shampoo, however, flocculation phenomenon easily occurs in the process of storage of the nano gold, so that the bacteriostatic effect of the nano gold is invalid, and the anti-dandruff effect is greatly reduced, and therefore, the shampoo has room for improvement.
Disclosure of Invention
In order to better and permanently keep the antibacterial effect of the anti-dandruff shampoo containing nano-gold stable, the application provides the anti-dandruff shampoo containing nano-gold and a preparation method thereof.
In a first aspect, the application provides an anti-dandruff shampoo containing nano-gold, which adopts the following technical scheme:
the anti-dandruff shampoo containing the nano gold comprises the following components in parts by weight:
71.05-73.34 minutes of solvent;
1.98-2.1 parts of conditioner;
0.03-0.05 part of pH regulator;
1.55-1.7 parts of thickener;
0.75-0.8 part of pearling agent;
20.25-21.8 parts of surfactant;
0.35-0.4 parts of di (hydrogenated tallow) phthalic acid amide;
0.45-0.5 part of suspension stabilizer;
0.9-1.1 parts of nano gold;
0-0.5 part of essence;
the thickener is the compounding of cetostearyl alcohol and sodium chloride.
By adopting the technical scheme, the shampoo has excellent anti-dandruff and sterilizing effects by adding the nano gold, and the nano gold can be permanently and stably uniformly distributed in the shampoo in the form of nano particles by compounding cetylstearyl alcohol, sodium chloride and di (hydrogenated tallow) phthalic acid amide and then matching with the nano gold, so that flocculation phenomenon is not easy to occur, and the anti-dandruff shampoo containing the nano gold is not easy to cause the reduction of antibacterial effect in long-term storage, can permanently maintain better anti-dandruff effect and has better quality.
Preferably, the mass ratio of the cetostearyl alcohol to the sodium chloride is 0.45-0.5:1.1-1.2.
By adopting the technical scheme, the effect of the combination of the cetylstearyl alcohol and the sodium chloride and the di (hydrogenated tallow) phthalic acid amide is better by specifically selecting the mass ratio of the cetylstearyl alcohol and the sodium chloride, so that the stability of the nano gold is better and permanently improved, flocculation failure of the nano gold is not easy to occur, and the quality of the shampoo is better.
Preferably, the mass ratio of the di (hydrogenated tallow) phthalic acid amide, cetostearyl alcohol and sodium chloride is 0.38:0.47:1.15.
by adopting the technical scheme, the nano gold has better effect by specifically selecting the mass ratio of di (hydrogenated tallow) phthalic acid amide, cetostearyl alcohol and sodium chloride, and can keep excellent sterilizing and scurf inhibiting effects after long-term storage.
Preferably, the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
By adopting the technical scheme, the conditioning agent is formed by specifically selecting guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil, so that the hair can be better conditioned, the hair is smoother, the hair quality is improved, the hair is not easy to be rough, and the hair is more attractive.
Preferably, the mass ratio of the guar hydroxypropyl trimethyl ammonium chloride to the emulsified silicone oil is 0.08-0.1:1.9-2.
By adopting the technical scheme, the effects of conditioning the hair and the scalp are better by specifically selecting the mass ratio of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil, so that the scalp is more balanced in water and oil, and the hair is more flexible and attractive.
Preferably, the surfactant is the compound of monoethanolamide cocoate, sodium laureth sulfate and cocamidopropyl betaine.
Through adopting above-mentioned technical scheme, through the compound surfactant formulation of concretely selecting coconut acid monoethanolamide, laureth sulfate sodium, cocoamidopropyl betaine, the cleaning performance to the dirt on scalp and the hair is better, can clean the hair better, makes the hair cleaner, and is more pleasing to the eye.
Preferably, the mass ratio of the coco monoethanolamide, sodium laureth sulfate and cocoamidopropyl betaine is 0.75-0.8:15-16:4.5-5.
By adopting the technical scheme, the cleaning effect is better, the hair is cleaner and the quality is better by specifically selecting the mass ratio of the coconut monoethanolamide, the sodium laureth sulfate and the cocoamidopropyl betaine.
In a second aspect, the application provides a preparation method of anti-dandruff shampoo containing nano-gold, which adopts the following technical scheme:
a preparation method of anti-dandruff shampoo containing nano-gold comprises the following steps:
step 1), adding 80-90% of solvent and guar hydroxypropyl trimethyl ammonium chloride into an emulsifying pot, uniformly stirring, then adding a pH regulator, and uniformly stirring to obtain a premix;
step 2), adding cetostearyl alcohol, pearling agent, coco monoethanolamide, di (hydrogenated tallow) phthalic acid amide and sodium laureth sulfate into the premix, heating to 85 ℃, uniformly stirring to obtain a mixture, and cooling;
step 3), adding cellulose, nano gold and the rest solvent into another homogenizing pot, homogenizing to obtain a homogeneous substance;
and 4) cooling the mixture to 45 ℃, adding the homogeneous substance, the emulsified silicone oil, the cocamidopropyl betaine and the sodium chloride into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
By adopting the technical scheme, the prepared shampoo has excellent effects of sterilizing and inhibiting dandruff, has good cleaning effect and hair and scalp care effect, is not easy to be degraded after being stored for a long time, and has more stable quality.
In summary, the application has the following beneficial effects:
1. the shampoo has excellent anti-dandruff and sterilizing effects by adding the nano gold, and can be permanently and stably distributed in the shampoo in the form of nano particles by compounding the cetylstearyl alcohol, the sodium chloride and the di (hydrogenated tallow) phthalic acid amide and then matching with the nano gold, so that flocculation phenomenon is not easy to occur, the anti-dandruff shampoo containing the nano gold is not easy to cause the reduction of antibacterial effect in long-term storage, and the good anti-dandruff effect and the good quality can be permanently maintained.
2. In the application, the mass ratio of the di (hydrogenated tallow) phthalic acid amide, the cetostearyl alcohol and the sodium chloride is preferably selected, so that the effect of the nano gold is better, and the excellent sterilizing and anti-dandruff effects can be well maintained after long-term storage.
3. The conditioning agent is preferably formed by compounding the guar hydroxypropyl trimethyl ammonium chloride and the emulsified silicone oil, so that the hair can be better conditioned, the hair is smoother, the hair quality is improved, the hair is not easy to be rough, and the hair is more attractive.
4. The surfactant is preferably formed by compounding the coconut monoethanolamide, the sodium laureth sulfate and the cocamidopropyl betaine, so that the cleaning effect on dirt on scalp and hair is good, the hair can be cleaned better, and the hair is cleaner and more attractive.
Detailed Description
The present application will be described in further detail with reference to examples.
Example 1
An anti-dandruff shampoo containing nano gold comprises the following components:
solvents, conditioning agents, pH regulators, thickeners, pearling agents, surfactants, di (hydrogenated tallow) phthalic acid amide, suspension stabilizers, nano gold and essence.
Wherein the solvent is deionized water, and the self-made solvent is self-made.
Wherein the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
Guar hydroxypropyl trimethylammonium chloride is purchased from sorv corporation.
Silicone emulsions were purchased from KCC corporation.
Wherein the pH regulator is citric acid, which is purchased from the chemical company of the ridge.
Wherein, the thickener is the compounding of cetostearyl alcohol and sodium chloride.
Cetyl stearyl alcohol is purchased from De Yuan.
Sodium chloride is purchased from the chemical company of the ridge.
Wherein, the pearling agent is glycol stearate, which is purchased from Basv company.
Wherein the surfactant is the compound of coco monoethanolamide, sodium laureth sulfate and cocamidopropyl betaine.
Coconut monoethanolamide is purchased from basf corporation.
Sodium laureth sulfate was purchased from Huawang corporation.
Cocamidopropyl betaine is purchased from basf corporation.
Among them, bis (hydrogenated tallow) phthalic acid amide was purchased from Kagaku corporation.
Wherein the suspension stabilizer is cellulose, purchased from SAPPI company.
Wherein, the nano gold is purchased from Yu An Nate Fei company and has the particle size of 1-10nm.
Wherein, essence is purchased from Korean Bill company.
The preparation method of the anti-dandruff shampoo containing the nano-gold comprises the following steps:
step 1), 66kg of deionized water and 0.08kg of guar hydroxypropyl trimethyl ammonium chloride are put into an emulsifying pot, uniformly stirred, then 0.03kg of citric acid is added, and uniformly stirred, thus obtaining a premix.
Step 2), adding 0.45kg of cetostearyl alcohol, 0.75kg of glycol stearate, 0.75kg of coconut monoethanolamide, 0.35kg of di (hydrogenated tallow) phthalic acid amide and 15kg of sodium laureth sulfate into the premix, heating to 85 ℃, stirring uniformly to obtain a mixture, and cooling.
Step 3), adding 0.45kg of cellulose, 0.9kg of nano gold and 7.34kg of deionized water into another homogenizing pot, and homogenizing to obtain a homogeneous substance.
And 4) cooling the mixture to 45 ℃, adding the homogeneous substance, 1.9kg of emulsified silicone oil, 4.5kg of cocamidopropyl betaine, 1.1kg of sodium chloride and 0.4kg of essence into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
Example 2
An anti-dandruff shampoo containing nano gold comprises the following components:
solvents, conditioning agents, pH regulators, thickeners, pearling agents, surfactants, di (hydrogenated tallow) phthalic acid amide, suspension stabilizers, nano gold and essence.
Wherein the solvent is deionized water, and the self-made solvent is self-made.
Wherein the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
Guar hydroxypropyl trimethylammonium chloride is purchased from sorv corporation.
Silicone emulsions were purchased from KCC corporation.
Wherein the pH regulator is citric acid, which is purchased from the chemical company of the ridge.
Wherein, the thickener is the compounding of cetostearyl alcohol and sodium chloride.
Cetyl stearyl alcohol is purchased from De Yuan.
Sodium chloride is purchased from the chemical company of the ridge.
Wherein, the pearling agent is glycol stearate, which is purchased from Basv company.
Wherein the surfactant is the compound of coco monoethanolamide, sodium laureth sulfate and cocamidopropyl betaine.
Coconut monoethanolamide is purchased from basf corporation.
Sodium laureth sulfate was purchased from Huawang corporation.
Cocamidopropyl betaine is purchased from basf corporation.
Among them, bis (hydrogenated tallow) phthalic acid amide was purchased from Kagaku corporation.
Wherein the suspension stabilizer is cellulose, purchased from SAPPI company.
Wherein, the nano gold is purchased from Yu An Nate Fei company and has the particle size of 1-10nm.
Wherein, essence is purchased from Korean Bill company.
The preparation method of the anti-dandruff shampoo containing the nano-gold comprises the following steps:
step 1), adding 61.36kg of deionized water and 0.09kg of guar hydroxypropyl trimethyl ammonium chloride into an emulsifying pot, uniformly stirring, then adding 0.04kg of citric acid, and uniformly stirring to obtain a premix.
Step 2), adding 0.47kg of cetostearyl alcohol, 0.78kg of glycol stearate, 0.78kg of coconut monoethanolamide, 0.38kg of di (hydrogenated tallow) phthalic acid amide and 15.5kg of sodium laureth sulfate into the premix, heating to 85 ℃, stirring uniformly to obtain a mixture, and cooling.
Step 3), adding 0.47kg of cellulose, 1kg of nano gold and 10.83kg of deionized water into another homogenizing pot, and homogenizing to obtain a homogeneous substance.
And 4) cooling the mixture to 45 ℃, adding the homogeneous substance, 1.95kg of emulsified silicone oil, 4.75kg of cocamidopropyl betaine, 1.15kg of sodium chloride and 0.45kg of essence into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
Example 3
An anti-dandruff shampoo containing nano gold comprises the following components:
solvents, conditioning agents, pH regulators, thickeners, pearling agents, surfactants, di (hydrogenated tallow) phthalic acid amide, suspension stabilizers, nano gold and essence.
Wherein the solvent is deionized water, and the self-made solvent is self-made.
Wherein the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
Guar hydroxypropyl trimethylammonium chloride is purchased from sorv corporation.
Silicone emulsions were purchased from KCC corporation.
Wherein the pH regulator is citric acid, which is purchased from the chemical company of the ridge.
Wherein, the thickener is the compounding of cetostearyl alcohol and sodium chloride.
Cetyl stearyl alcohol is purchased from De Yuan.
Sodium chloride is purchased from the chemical company of the ridge.
Wherein, the pearling agent is glycol stearate, which is purchased from Basv company.
Wherein the surfactant is the compound of coco monoethanolamide, sodium laureth sulfate and cocamidopropyl betaine.
Coconut monoethanolamide is purchased from basf corporation.
Sodium laureth sulfate was purchased from Huawang corporation.
Cocamidopropyl betaine is purchased from basf corporation.
Among them, bis (hydrogenated tallow) phthalic acid amide was purchased from Kagaku corporation.
Wherein the suspension stabilizer is cellulose, purchased from SAPPI company.
Wherein, the nano gold is purchased from Yu An Nate Fei company and has the particle size of 1-10nm.
Wherein, essence is purchased from Korean Bill company.
The preparation method of the anti-dandruff shampoo containing the nano-gold comprises the following steps:
step 1), putting 56.84kg of deionized water and 0.1kg of guar hydroxypropyl trimethyl ammonium chloride into an emulsifying pot, uniformly stirring, then adding 0.05kg of citric acid, and uniformly stirring to obtain a premix.
Step 2), adding 0.5kg of cetostearyl alcohol, 0.8kg of glycol stearate, 0.8kg of coconut monoethanolamide, 0.4kg of di (hydrogenated tallow) phthalic acid amide and 16kg of sodium laureth sulfate into the premix, heating to 85 ℃, stirring uniformly to obtain a mixture, and cooling.
Step 3), adding 0.5kg of cellulose, 1.1kg of nano gold and 14.21kg of deionized water into another homogenizing pot, and homogenizing to obtain a homogeneous substance.
And 4) cooling the mixture to 45 ℃, adding the homogeneous substance, 2kg of emulsified silicone oil, 5kg of cocamidopropyl betaine, 1.2kg of sodium chloride and 0.5kg of essence into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
Example 4
An anti-dandruff shampoo containing nano gold comprises the following components:
solvents, conditioning agents, pH regulators, thickeners, pearling agents, surfactants, di (hydrogenated tallow) phthalic acid amide, suspension stabilizers, nano gold and essence.
Wherein the solvent is deionized water, and the self-made solvent is self-made.
Wherein the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
Guar hydroxypropyl trimethylammonium chloride is purchased from sorv corporation.
Silicone emulsions were purchased from KCC corporation.
Wherein the pH regulator is citric acid, which is purchased from the chemical company of the ridge.
Wherein, the thickener is the compounding of cetostearyl alcohol and sodium chloride.
Cetyl stearyl alcohol is purchased from De Yuan.
Sodium chloride is purchased from the chemical company of the ridge.
Wherein, the pearling agent is glycol stearate, which is purchased from Basv company.
Wherein the surfactant is the compound of coco monoethanolamide, sodium laureth sulfate and cocamidopropyl betaine.
Coconut monoethanolamide is purchased from basf corporation.
Sodium laureth sulfate was purchased from Huawang corporation.
Cocamidopropyl betaine is purchased from basf corporation.
Among them, bis (hydrogenated tallow) phthalic acid amide was purchased from Kagaku corporation.
Wherein the suspension stabilizer is cellulose, purchased from SAPPI company.
Wherein, the nano gold is purchased from Yu An Nate Fei company and has the particle size of 1-10nm.
Wherein, essence is purchased from Korean Bill company.
The preparation method of the anti-dandruff shampoo containing the nano-gold comprises the following steps:
step 1), adding 61.36kg of deionized water and 0.09kg of guar hydroxypropyl trimethyl ammonium chloride into an emulsifying pot, uniformly stirring, then adding 0.04kg of citric acid, and uniformly stirring to obtain a premix.
Step 2), adding 0.27 kg of cetostearyl alcohol, 0.78kg of glycol stearate, 0.78kg of coconut monoethanolamide, 0.38kg of di (hydrogenated tallow) phthalic acid amide and 15.5kg of sodium laureth sulfate into the premix, heating to 85 ℃, stirring uniformly to obtain a mixture, and cooling.
Step 3), adding 0.47kg of cellulose, 1kg of nano gold and 10.83kg of deionized water into another homogenizing pot, and homogenizing to obtain a homogeneous substance.
And 4) cooling the mixture to 45 ℃, adding the homogeneous substance, 1.95kg of emulsified silicone oil, 4.75kg of cocamidopropyl betaine, 1.35kg of sodium chloride and 0.45kg of essence into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
Example 5
An anti-dandruff shampoo containing nano gold comprises the following components:
solvents, conditioning agents, pH regulators, thickeners, pearling agents, surfactants, di (hydrogenated tallow) phthalic acid amide, suspension stabilizers, nano gold and essence.
Wherein the solvent is deionized water, and the self-made solvent is self-made.
Wherein the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
Guar hydroxypropyl trimethylammonium chloride is purchased from sorv corporation.
Silicone emulsions were purchased from KCC corporation.
Wherein the pH regulator is citric acid, which is purchased from the chemical company of the ridge.
Wherein, the thickener is the compounding of cetostearyl alcohol and sodium chloride.
Cetyl stearyl alcohol is purchased from De Yuan.
Sodium chloride is purchased from the chemical company of the ridge.
Wherein, the pearling agent is glycol stearate, which is purchased from Basv company.
Wherein the surfactant is the compound of coco monoethanolamide, sodium laureth sulfate and cocamidopropyl betaine.
Coconut monoethanolamide is purchased from basf corporation.
Sodium laureth sulfate was purchased from Huawang corporation.
Cocamidopropyl betaine is purchased from basf corporation.
Among them, bis (hydrogenated tallow) phthalic acid amide was purchased from Kagaku corporation.
Wherein the suspension stabilizer is cellulose, purchased from SAPPI company.
Wherein, the nano gold is purchased from Yu An Nate Fei company and has the particle size of 1-10nm.
Wherein, essence is purchased from Korean Bill company.
The preparation method of the anti-dandruff shampoo containing the nano-gold comprises the following steps:
step 1), adding 61.36kg of deionized water and 0.09kg of guar hydroxypropyl trimethyl ammonium chloride into an emulsifying pot, uniformly stirring, then adding 0.04kg of citric acid, and uniformly stirring to obtain a premix.
Step 2), adding 0.67 kg of cetostearyl alcohol, 0.78kg of glycol stearate, 0.78kg of coconut monoethanolamide, 0.38kg of di (hydrogenated tallow) phthalic acid amide and 15.5kg of sodium laureth sulfate into the premix, heating to 85 ℃, stirring uniformly to obtain a mixture, and cooling.
Step 3), adding 0.47kg of cellulose, 1kg of nano gold and 10.83kg of deionized water into another homogenizing pot, and homogenizing to obtain a homogeneous substance.
And 4) cooling the mixture to 45 ℃, adding the homogeneous substance, 1.95kg of emulsified silicone oil, 4.75kg of cocamidopropyl betaine, 0.95kg of sodium chloride and 0.45kg of essence into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
Comparative example 1
An antidandruff shampoo containing nanogold differs from example 2 only in that:
equivalent substitution of bis (hydrogenated tallow) phthalic acid amide with PEG-10 polydimethylsiloxane.
Among them, PEG-10 polydimethylsiloxane is commercially available from CAS number: 68937-54-2.
Comparative example 2
An antidandruff shampoo containing nanogold differs from example 2 only in that:
equal amounts of behenyl alcohol were used instead of cetostearyl alcohol.
Wherein, behenyl alcohol is from commercial, CAS number: 661-19-8.
Comparative example 3
An antidandruff shampoo containing nanogold differs from example 2 only in that:
magnesium chloride was used in place of sodium chloride in equal amounts.
Wherein, magnesium chloride is from commercial market, CAS number: 7786-30-3.
Comparative example 4
An antidandruff shampoo containing nanogold differs from example 2 only in that:
equivalent substitution of bis (hydrogenated tallow) phthalic acid amide with PEG-10 polydimethylsiloxane.
Equal amounts of behenyl alcohol were used instead of cetostearyl alcohol.
Magnesium chloride was used in place of sodium chloride in equal amounts.
Among them, PEG-10 polydimethylsiloxane is commercially available from CAS number: 68937-54-2.
Wherein, behenyl alcohol is from commercial, CAS number: 661-19-8.
Wherein, magnesium chloride is from commercial market, CAS number: 7786-30-3.
Experiment 1
According to the bacteriostasis ring method of QB/T2738-2012 (evaluation method of antibacterial and bacteriostatic effect of daily chemical products) 7.5, the antibacterial effect of the anti-dandruff shampoo containing nano-gold prepared by each example and comparative example is detected, the antibacterial effect is evaluated by the diameter of the bacteriostasis ring, and the larger the diameter of the bacteriostasis ring is, the better the antibacterial effect is, and the diameter of the bacteriostasis ring is larger than 7mm, so that the anti-dandruff shampoo containing nano-gold has the antibacterial effect.
Placing the anti-dandruff shampoo containing the nano gold prepared in each example and comparative example in a transparent glass bottle, opening, keeping the temperature at 45 ℃ and the constant humidity at 90%, performing accelerated aging, standing for 30 days, sampling, detecting according to the QB/T2738-2012 antibacterial and bacteriostatic effect evaluation method of daily chemical products, 7.5 antibacterial ring method, marking as the diameter of the antibacterial ring after storage, and judging the stability of the anti-dandruff shampoo containing the nano gold after storage according to the change of antibacterial effect.
Test strain: malassezia furfur, strain number: ATCC 44344.
When the antibacterial effect of the freshly prepared anti-dandruff shampoo containing nano-gold is tested, the concentration of the bacterial suspension for test is 7.9x10 5 The method comprises the steps of carrying out a first treatment on the surface of the When the antibacterial effect of the stored anti-dandruff shampoo containing nano-gold is tested, the concentration of the bacterial suspension for test is 7.8x10 5
The specific test data for experiment 1 are detailed in table 1.
TABLE 1
Diameter of inhibition ring (mm) Diameter (mm) of bacteriostasis ring after storage
Example 1 24.88 22.72
Example 2 24.95 22.77
Example 3 24.93 22.74
Example 4 24.89 22.24
Example 5 24.94 22.33
Comparative example 1 24.91 6.25
Comparative example 2 24.86 6.37
Comparative example 3 24.92 6.19
Comparative example 4 24.87 6.42
According to the data in table 1, the comparison between the examples and the comparative examples shows that when the bis (hydrogenated tallow) phthalic acid amide, cetostearyl alcohol and sodium chloride are adopted for compounding, the stability of the nano gold is higher, the shampoo of each example still maintains good antibacterial effect after being stored for 30 days under the accelerated aging condition, the antibacterial effect of the shampoo of each comparative example is less changed, the antibacterial effect of the shampoo of each comparative example is obviously reduced, and the phenomenon that the antibacterial effect is invalid due to flocculation of the nano gold is caused by changing the compounding system of the bis (hydrogenated tallow) phthalic acid amide, cetylstearyl alcohol and sodium chloride is proved, so that the shampoo of each example has longer lasting stability and better quality.
According to the data in Table 1, the comparison of examples 1-3 with examples 4-5 shows that the effect of maintaining the stability of the nanogold in the shampoo is better when bis (hydrogenated tallow) phthalic acid amide, cetostearyl alcohol, sodium chloride are compounded in a specific ratio, the diameter of the bacteriostasis ring is reduced less after 30 days of storage under accelerated aging conditions, and the shampoo of examples 1-3 has more durable stability and better quality.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.

Claims (8)

1. An anti-dandruff shampoo containing nano-gold, which is characterized in that: the composite material consists of the following components in parts by weight:
71.05-73.34 minutes of solvent;
1.98-2.1 parts of conditioner;
0.03-0.05 part of pH regulator;
1.55-1.7 parts of thickener;
0.75-0.8 part of pearling agent;
20.25-21.8 parts of surfactant;
0.35-0.4 parts of di (hydrogenated tallow) phthalic acid amide;
0.45-0.5 part of suspension stabilizer;
0.9-1.1 parts of nano gold;
0-0.5 part of essence;
the thickener is the compounding of cetostearyl alcohol and sodium chloride.
2. An anti-dandruff shampoo comprising nanogold according to claim 1, wherein: the mass ratio of the cetostearyl alcohol to the sodium chloride is 0.45-0.5:1.1-1.2.
3. An anti-dandruff shampoo comprising nanogold according to claim 2, wherein: the mass ratio of the di (hydrogenated tallow) phthalic acid amide to the cetostearyl alcohol to the sodium chloride is 0.38:0.47:1.15.
4. an anti-dandruff shampoo comprising nanogold according to claim 1, wherein: the conditioning agent is the compound of guar hydroxypropyl trimethyl ammonium chloride and emulsified silicone oil.
5. The anti-dandruff shampoo comprising nanogold according to claim 4, wherein: the mass ratio of the guar hydroxypropyl trimethyl ammonium chloride to the emulsified silicone oil is 0.08-0.1:1.9-2.
6. An anti-dandruff shampoo comprising nanogold according to claim 1, wherein: the surfactant is the compound of coco monoethanolamide, sodium laureth sulfate and cocamidopropyl betaine.
7. The anti-dandruff shampoo comprising nanogold according to claim 6, wherein: the mass ratio of the coco monoethanolamide to sodium laureth sulfate to the coco amidopropyl betaine is 0.75-0.8:15-16:4.5-5.
8. A preparation method of anti-dandruff shampoo containing nano-gold is characterized in that: the method comprises the following steps:
step 1), adding 80-90% of solvent and guar hydroxypropyl trimethyl ammonium chloride into an emulsifying pot, uniformly stirring, then adding a pH regulator, and uniformly stirring to obtain a premix;
step 2), adding cetostearyl alcohol, pearling agent, coco monoethanolamide, di (hydrogenated tallow) phthalic acid amide and sodium laureth sulfate into the premix, heating to 85 ℃, uniformly stirring to obtain a mixture, and cooling;
step 3), adding cellulose, nano gold and the rest solvent into another homogenizing pot, homogenizing to obtain a homogeneous substance;
and 4) cooling the mixture to 45 ℃, adding the homogeneous substance, the emulsified silicone oil, the cocamidopropyl betaine and the sodium chloride into the mixture, and uniformly stirring to obtain the anti-dandruff shampoo containing the nano-gold.
CN202310635082.6A 2023-05-31 2023-05-31 Anti-dandruff shampoo containing nano-gold and preparation method thereof Active CN116602890B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310635082.6A CN116602890B (en) 2023-05-31 2023-05-31 Anti-dandruff shampoo containing nano-gold and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310635082.6A CN116602890B (en) 2023-05-31 2023-05-31 Anti-dandruff shampoo containing nano-gold and preparation method thereof

Publications (2)

Publication Number Publication Date
CN116602890A true CN116602890A (en) 2023-08-18
CN116602890B CN116602890B (en) 2024-02-09

Family

ID=87685172

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202310635082.6A Active CN116602890B (en) 2023-05-31 2023-05-31 Anti-dandruff shampoo containing nano-gold and preparation method thereof

Country Status (1)

Country Link
CN (1) CN116602890B (en)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050077237A (en) * 2004-01-27 2005-08-01 현천근 Composition of sterilization use shampoo
CN101049279A (en) * 2007-04-30 2007-10-10 孙仲毅 Antibacterial shampoo of Nano silver, and preparation method
KR20080035821A (en) * 2006-10-20 2008-04-24 (주) 비앤씨피 With white gold colloidal the reed article composition which contains
CN108403611A (en) * 2018-06-04 2018-08-17 云南健牛生物科技有限公司 A kind of efficient sterilizing anticreep promotees hair tonic shampoo and preparation method thereof
WO2019053480A1 (en) * 2017-09-18 2019-03-21 Plin Nanotechnology S.A. Nano-enhanced animal shampoo
CN110327282A (en) * 2019-08-19 2019-10-15 佛山市绿邮网络科技有限公司 A kind of dandruff control shampoo containing and preparation process improving scalp epidermis microbial flora
CN110680761A (en) * 2019-10-28 2020-01-14 佛山市安安美容保健品有限公司 Liquid shampoo
CN111568802A (en) * 2020-06-18 2020-08-25 广州家化化学有限公司 Nano-cellulose anti-dandruff shampoo and preparation method thereof
KR102445954B1 (en) * 2021-09-30 2022-09-22 주식회사 에이유랩스 Manufacturing Method of Composition For Wrinkle Reduction Comprising Niacinamide Deposited With Gold Nanoparticle
CN115813841A (en) * 2023-01-10 2023-03-21 广东迪美新材料科技有限公司 Anti-dandruff and itching-relieving composition, preparation method and application thereof, shampoo and preparation method

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050077237A (en) * 2004-01-27 2005-08-01 현천근 Composition of sterilization use shampoo
KR20080035821A (en) * 2006-10-20 2008-04-24 (주) 비앤씨피 With white gold colloidal the reed article composition which contains
CN101049279A (en) * 2007-04-30 2007-10-10 孙仲毅 Antibacterial shampoo of Nano silver, and preparation method
WO2019053480A1 (en) * 2017-09-18 2019-03-21 Plin Nanotechnology S.A. Nano-enhanced animal shampoo
CN108403611A (en) * 2018-06-04 2018-08-17 云南健牛生物科技有限公司 A kind of efficient sterilizing anticreep promotees hair tonic shampoo and preparation method thereof
CN110327282A (en) * 2019-08-19 2019-10-15 佛山市绿邮网络科技有限公司 A kind of dandruff control shampoo containing and preparation process improving scalp epidermis microbial flora
CN110680761A (en) * 2019-10-28 2020-01-14 佛山市安安美容保健品有限公司 Liquid shampoo
CN111568802A (en) * 2020-06-18 2020-08-25 广州家化化学有限公司 Nano-cellulose anti-dandruff shampoo and preparation method thereof
KR102445954B1 (en) * 2021-09-30 2022-09-22 주식회사 에이유랩스 Manufacturing Method of Composition For Wrinkle Reduction Comprising Niacinamide Deposited With Gold Nanoparticle
CN115813841A (en) * 2023-01-10 2023-03-21 广东迪美新材料科技有限公司 Anti-dandruff and itching-relieving composition, preparation method and application thereof, shampoo and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
T. DEVASENA, 等: "Activity of Ketoconazole Coated Gold Nanoparticles Against Dandruff Causing Fungi", ASIAN JOURNAL OF BIO SCIENCE, vol. 4, no. 1, pages 44 - 46 *
袁阳明, 等: "常用悬浮剂对洗发香波悬浮与调理性能的影响", 日用化学品科学, vol. 42, no. 03, pages 32 - 36 *

Also Published As

Publication number Publication date
CN116602890B (en) 2024-02-09

Similar Documents

Publication Publication Date Title
CN109381480B (en) Compound polyhexamethylene biguanide disinfectant and preparation method thereof
DE69431646T2 (en) Shampoos and conditioners
US4329336A (en) Nonionic based antimicrobial shampoo
US9937110B2 (en) Translucent gel system
US4456543A (en) Bisbiguanide based antibacterial cleansing products
CN108066164A (en) A kind of transparent compound cleaning compositions and preparation method thereof
JP2010275198A (en) Composition for cleaning
JP5806526B2 (en) Foam enhancer and detergent composition containing the same
CN116602890B (en) Anti-dandruff shampoo containing nano-gold and preparation method thereof
US3196173A (en) Aminoalkanesulfonic acids
US20100254931A1 (en) Use of long carbon chain quaternary ammonium salt phosphoric acid ester as conditioner for hair
JPH09118606A (en) Hair treating agent
JP6134118B2 (en) Liquid detergent composition
CN112981947B (en) Low-irritation fabric softening and degerming agent and preparation method thereof
JP3082386B2 (en) Shampoo composition
CN101485618B (en) Composition and application thereof as scurf-eliminating and itch-stopping agent
CN114788790A (en) Amino acid surfactant composition and application thereof
JP6216185B2 (en) Polyoxyalkylene alkylamine type thickener, thickener composition, and high viscosity liquid detergent composition
JP3868823B2 (en) Cleaning composition
JP2007106727A (en) Cosmetic raw material composition and antisepsis method of cosmetic raw material composition
JPH0812535A (en) Shampoo
KR100828021B1 (en) Fabric softener composition
CN112515996B (en) Antibacterial hand sanitizer and preparation method thereof
CN111944139B (en) Surfactant, synthetic method and application of surfactant
Jordà et al. A new effective, sustainable conditioning system (NCS)

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant