CN110721125A - Raw material composition for promoting human keratinocyte proliferation and application thereof - Google Patents
Raw material composition for promoting human keratinocyte proliferation and application thereof Download PDFInfo
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- CN110721125A CN110721125A CN201810775424.3A CN201810775424A CN110721125A CN 110721125 A CN110721125 A CN 110721125A CN 201810775424 A CN201810775424 A CN 201810775424A CN 110721125 A CN110721125 A CN 110721125A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention provides a raw material composition for promoting human keratinocyte proliferation, which comprises the following components in percentage by mass: 0.5-15% of malto-oligosaccharide; 0.001-2.5% of glucan; 0.01-5% of licorice extract; 1-40% of a eucalyptus globulus leaf extract; 0-98.489% of a solvent; the balance of water. The solvent is an alcohol solvent. The raw material composition has multiple functions of moisturizing, resisting inflammation, sterilizing, relieving itching, promoting proliferation of human keratinocytes and the like, and can be used for preparing skin care products. Under the premise of a specific proportion, the components such as maltooligosaccharide and glucan effectively inhibit the flocculation of the eucalyptus globulus leaf extract, so that the stability is good, and the prepared skin care product also has good stability. The scalp care product is used for scalp care, can effectively improve the anti-inflammatory capability of the scalp, keep the scalp moist, enhance the immunity and the resistance of the scalp, intrinsically regulate the activity of skin cells, promote the proliferation of scalp keratinocytes and further prevent alopecia.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a raw material composition for promoting human keratinocyte proliferation and application thereof.
Background
Almost every consumer wants to have beautiful and healthy hair. The scalp is the soil in which hair grows. Just as the quality of the soil can directly affect crop harvest, the health of the scalp can directly affect the health of the hair, and thus the overall aesthetics of the individual.
Alopecia is one of the most common health problems of the scalp. Alopecia is caused by a number of causes, among which the effects of hormones on hair life cycle leading to alopecia are undisputed, but other factors can also affect and exacerbate alopecia. When the scalp is exposed to external environmental pressure and irritants such as pollutants, such as sunlight, air pollutants, smoke and other irritants, the scalp can trigger the immune function of the scalp to cause inflammation. The overstimulation of inflammatory reaction can affect blood circulation, on one hand, the nutrition needed by cell growth is insufficient, and the renewal activity of epidermal cells is delayed; on the other hand, the inflammation reaction products can not be excreted in time, so that the inflammation reaction products are accumulated continuously, the scalp becomes dry, the elasticity is reduced, and the scalp is aged. If the hair follicle becomes inflamed and the surrounding tissue hardens, resulting in poor hair anchorage and premature hair loss, the hair cannot grow properly. Therefore, scalp care is not always necessary for hair care, and attention to scalp care has been increasingly paid in recent years.
Healthy scalp care is primarily to eliminate adverse factors affecting scalp health, such as the removal of bacteria, fungi, excess unsaturated fatty acids, sebum oxide, and the like. Secondly, the scalp is protected from stimulation of excessive ultraviolet rays and pollutants such as PM 2.5, industrial waste gas and the like, and the defense functions such as barrier function, blood circulation, anti-inflammatory capability and the like of the scalp are improved by improving the environment. The core of scalp care is to maintain the normal metabolism of scalp cells, promote the proliferation of human keratinocytes and provide a guarantee for maintaining the normal metabolism of scalp cells.
Therefore, it is very important to develop a raw material composition for promoting the proliferation of human keratinocytes, which can be used for scalp care and thus prevent alopecia.
Disclosure of Invention
The inventor of the invention has intensively studied and found that the eucalyptus globulus labill leaf extract, the malto-oligosaccharide, the glucan and other components can form a stable raw material composition under a specific proportion, can effectively promote the proliferation of human keratinocytes, and can be used for preparing skin care products, such as scalp care products, body care products and cosmetics for preventing alopecia.
The first object of the present invention is to provide a raw material composition for promoting the proliferation of human keratinocytes, which can be used for preparing scalp care products, body care products and cosmetics.
In order to achieve the purpose, the invention adopts the following technical scheme:
the raw material composition for promoting the proliferation of human keratinocytes comprises the following components in percentage by mass:
the solvent is an alcohol solvent.
According to the invention, the eucalyptus globulus leaf extract, the malto-oligosaccharide, the glucan and other components can form a stable raw material composition in a specific proportion, and the proliferation of human keratinocytes can be effectively promoted. Wherein the malto-oligosaccharide can also act as a humectant and help to inhibit flocculation of the Eucalyptus globulus Labill leaf extract. When the mass percent of the malto-oligosaccharide is more than 0.5 percent, the raw material composition mixture is stable. The glucan also has moisturizing effect. Meanwhile, the glucan and the maltooligosaccharide act synergistically to inhibit the agglomeration of the eucalyptus globulus leaf extract. When the mass percentage of the glucan is less than 0.001%, the raw material composition mixture is unstable.
According to the present invention, when the content of the licorice extract exceeds 5% by mass, the stability of the raw material composition mixture is affected, and if the content is less than 0.01%, the effect expected by the present invention is weak.
According to the invention, the eucalyptus globulus leaf extract can cause skin irritation if the mass percentage of the eucalyptus globulus leaf extract exceeds 40%. When the content of the blue eucalyptus leaf extract is less than 1%, the effect expected by the present invention is weak.
The cell proliferation rate of human keratinocytes of the composition prepared under the specific formula conditions is 10-60%. Preferably 20 to 60%.
According to the present invention, preferably, the raw material composition for promoting proliferation of human keratinocytes comprises the following components by mass:
the solvent is an alcohol solvent.
Under the condition of the mass percentage, the raw material composition has better effect of promoting the proliferation of human keratinocytes.
According to the invention, the alcohol solvent is selected from one or more of 1, 3-butanediol, ethanol and glycerol.
Preferably, the alcoholic solvent is 1, 3-butanediol or ethanol or a mixture of the two.
Further preferably, the alcohol solvent is 1, 3-butanediol.
The water is preferably deionized water or purified water.
According to the invention, the malto-oligosaccharide is a polymer composed of alpha-glucose monomers, and comprises maltotriose and maltotetraose, wherein the mass percent of the maltotetraose is 1-96%.
Further, the compound also comprises maltose pentasaccharide.
According to the invention, the glucan is selected from glucan separated and purified from a saccharomyces cerevisiae culture solution.
According to the invention, the effective components of the licorice extract comprise dipotassium glycyrrhizinate and glabridin, wherein the mass percent of the dipotassium glycyrrhizinate in the licorice extract is 80-98%, and the mass percent of the glabridin in the licorice extract is 0.001-0.2%.
According to the invention, the extract of the leaves of the eucalyptus globulus is selected from the extract of the young leaves of the eucalyptus globulus in the growing period of 2-3 years. The young leaves of the blue eucalyptus in the growth period of 2-3 years are used as the raw material of the blue eucalyptus leaf extract, so that the high content of effective components in the blue eucalyptus leaf extract can be ensured.
In the invention, the eucalyptus globulus leaf extract can be in a liquid state without spray drying after extraction, and contains a solvent and a solid substance.
The Eucalyptus globulus Labill leaf extract can also be powder obtained by spray drying after extraction. In application, the powdered Eucalyptus globulus Labill leaf extract is diluted with solvent to form liquid.
The solvent is preferably a solvent used for extracting eucalyptus globulus leaves.
Preferably, the solid content of the eucalyptus globulus leaf extract is 0.01-5 wt%.
The second purpose of the invention is to provide a preparation method of the raw material composition, which comprises the following preparation steps:
1) adding the liquorice extract, the eucalyptus globulus labill leaf extract and the solvent into a container according to the formula ratio, and uniformly stirring to obtain a mixture A;
2) adding the malto-oligosaccharide, the glucan and the water in the formula ratio into the mixture A prepared in the step 1), and uniformly stirring to obtain the raw material composition.
In the step 1), the eucalyptus globulus labill leaf extract is preferably added with 1, 3-butanediol in a formula amount if the extract is extracted by 1, 3-butanediol. If ethanol is used for extraction, the amount of ethanol to be formulated is preferably added.
The third purpose of the invention is to provide the application of the raw material composition, which is used for promoting the proliferation of human keratinocytes.
According to the present invention, the above-described raw material composition can be used for preparing skin care products including scalp care products, body care products and cosmetics.
Further, according to the present invention, the above raw material composition can be used for preparing a scalp care product for promoting the proliferation of keratinocytes and preventing hair loss.
Compared with the prior art, the invention has the following beneficial technical effects:
(1) the raw material composition has multiple functions of moisturizing, resisting inflammation, sterilizing, relieving itching, promoting the proliferation of human keratinocytes and the like, and can be used for preparing skin care products, such as scalp care products, body care products and cosmetics.
(2) On the premise of a specific proportion, the components such as malto-oligosaccharide and glucan act together with the eucalyptus globulus labill leaf extract, and the glucan is used as an inclusion agent to uniformly disperse the eucalyptus globulus labill leaf extract and finally form an oil-in-water type water phase dispersion system, so that the flocculation of the eucalyptus globulus labill leaf extract is effectively inhibited, and the eucalyptus globulus labill leaf extract has good stability. The skin care products prepared with the composition of the present invention also have good stability, and thus, the use of the eucalyptus globulus leaf extract in the field of skin care products such as scalp care products, body care products and cosmetics is significantly improved.
(3) The scalp care agent is used for scalp care, can effectively improve the anti-inflammatory capacity of the scalp, keep the scalp moist, enhance the immunity and the resistance of the scalp, intrinsically regulate the activity of skin cells, promote the proliferation of scalp keratinocytes and further prevent alopecia.
Detailed Description
The present invention will be further described with reference to the following examples. It should be understood that the following examples are illustrative only and are not intended to limit the scope of the present invention.
In the following examples, the starting materials and equipment were all commercially available.
The malto-oligosaccharide is derived from hydrolyzed corn starch.
The glucan is selected from glucan separated and purified from a black yeast culture solution.
The Glycyrrhrizae radix extract is commercially available product and is purchased from pill-type pharmaceutical Co
The Eucalyptus globulus leaf extract is a commercially available product and is purchased from Nichio oil Co. Or extracting with alcohol solvent such as 1, 3-butanediol, ethanol and glycerol or mixture of alcohol solvents by conventional method.
Examples 1-15 preparation of starting compositions
The raw material compositions of examples 1 to 15 were prepared in the following formulation as shown in Table 1.
Table 1 formulation of the raw material composition
"-" indicates that the component is not contained.
TABLE 1 continuation of the table
"-" indicates that the component is not contained.
A method of preparing the feedstock compositions of examples 1-15, comprising the steps of:
1) adding the liquorice extract, the eucalyptus globulus labill leaf extract and the solvent into a container according to the formula ratio, and uniformly stirring to obtain a mixture A;
2) adding the malto-oligosaccharide, the glucan and the water in the formula ratio into the mixture A prepared in the step 1), and uniformly stirring to obtain the raw material composition of the examples 1-15, wherein the raw material composition is brown transparent liquid.
The starting compositions prepared in examples 1-15 have good stability. The obtained product has good stability after being prepared into scalp care product, body care product or cosmetic. After 6 months of storage under the conditions of low temperature (4 ℃) and high temperature (50 ℃), the product has no demixing and flocculation, thus still having good stability.
Example 16 in vitro keratinocyte proliferation assay
The starting compositions prepared in examples 1-15 were used in an in vitro keratinocyte proliferation assay comprising the steps of:
(1) human keratinocytes were added at a ratio of 1X 10 per well3The density of individual cells was seeded in 96-well plates.
(2) The next day after cell inoculation, 0.5. mu.l of ethanol (as control 1), 0.5. mu.l of 1, 3-butanediol (as control 2), and the raw material compositions of examples 1 to 14 diluted to 0.06% by mass (as test groups) were added to the 96-well plate, respectively.
(3) Then in CO2Incubate at 25 ℃ for 24 hours.
(4) And 10. mu.l of cell counting kit-8(CCK-8) was added to each of the test group and the control group in CO2After culturing for 3 hours in the incubator, the absorbance at 450nm of the test group, control group 1 and control group 2 was measured using a microplate reader, and the cell proliferation rate of human keratinocytes was calculated from the absorbance, and the results are shown in table 2.
TABLE 2 cell proliferation Rate
TABLE 2 continuation of the table
As is apparent from the data of Table 2, the raw material compositions prepared in examples 1 to 15 all had significant cell proliferation effects, whereas the cell proliferation rates of control 1 containing only ethanol and control 2 containing only 1, 3-butanediol were 0. Description of the drawings: the malto-oligosaccharide, the glucan, the licorice extract and the eucalyptus globulus leaf extract act together to remarkably promote cell proliferation.
Example 4 formulation lacking eucalyptus globulus leaf extract, example 10 formulation lacking licorice extract, example 12 formulation lacking glucan, example 13 formulation lacking malto-oligosaccharide, example 14 formulation lacking glucan and malto-oligosaccharide. Compared with other examples, the cell proliferation rate of examples 4, 10, 12 to 14 was as low as 1 to 3, which shows that: the raw material composition does not have a good cell proliferation promoting effect in the absence of any one of maltooligosaccharide, dextran and licorice extract.
In summary, combining table 1 and table 2, the raw material composition for promoting proliferation of human keratinocytes of the present invention comprises the following components by mass:
the solvent is an alcohol solvent.
The cell proliferation rate of human keratinocytes of the composition prepared under the specific formula conditions is 10-60%.
The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. It will be readily apparent to those skilled in the art that the starting composition of the present invention may also be used to prepare products such as body care products where it is desired to promote the proliferation of human keratinocytes. Any equivalent modifications and substitutions to the practice are also within the scope of the invention. Accordingly, it is intended that all equivalent alterations and modifications be included within the scope of the invention, without departing from the spirit and scope of the invention.
Claims (10)
1. The raw material composition for promoting the proliferation of human keratinocytes is characterized by comprising the following components in percentage by mass:
the solvent is an alcohol solvent.
2. The raw material composition for promoting the proliferation of human keratinocytes according to claim 1, comprising the following components in percentage by mass:
the solvent is an alcohol solvent.
3. The starting composition for promoting the proliferation of human keratinocytes according to claim 1 or 2, wherein said alcoholic solvent is selected from the group consisting of 1, 3-butanediol, ethanol, glycerol, and mixtures thereof.
4. The raw material composition for promoting proliferation of human keratinocytes according to claim 1 or 2, wherein the maltooligosaccharide comprises maltotriose and maltotetraose, and the mass percentage of the maltotetraose is 1 to 96%.
5. The raw material composition for promoting proliferation of human keratinocytes according to claim 1 or 2, wherein the glucan is a glucan isolated and purified from a culture solution of Saccharomyces nigricans.
6. The composition as claimed in claim 1 or 2, wherein the effective components of the licorice extract comprise dipotassium glycyrrhizinate and glabridin, wherein the dipotassium glycyrrhizinate accounts for 80-98% of the weight of the licorice extract, and the glabridin accounts for 0.001-0.2% of the weight of the licorice extract.
7. The raw material composition for promoting proliferation of human keratinocytes according to claim 1 or 2, wherein the solid content of the eucalyptus globulus leaf extract is 0.01 to 5 wt%.
8. The method for preparing a starting composition for promoting the proliferation of human keratinocytes according to any one of claims 1 to 7, comprising the following steps:
1) adding the liquorice extract, the eucalyptus globulus labill leaf extract and the solvent into a reaction container according to the formula ratio, and uniformly stirring to obtain a mixture A;
2) adding malto-oligosaccharide, glucan and water in the formula ratio into the mixture A prepared in the step 1), and uniformly stirring to obtain the raw material composition for promoting the proliferation of human keratinocytes.
9. Use of a starting composition for promoting proliferation of human keratinocytes as defined in any one of claims 1 to 8, for promoting proliferation of human keratinocytes.
10. Use of a starting composition for promoting the proliferation of human keratinocytes according to claim 9, characterized in that it is used for the preparation of scalp care products, preventing hair loss.
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| CN201810775424.3A CN110721125A (en) | 2018-07-16 | 2018-07-16 | Raw material composition for promoting human keratinocyte proliferation and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090143714A1 (en) * | 2007-11-29 | 2009-06-04 | Cheri Lynn Millikin | Regulation of Mammalian Keratinous Tissue Using Skin and/or Hair Care Actives |
| CN104436118A (en) * | 2014-11-18 | 2015-03-25 | 天津钧濡科技有限公司 | Anti-dropping hair restoring liquid |
| CN106214592A (en) * | 2016-09-09 | 2016-12-14 | 美萃国际贸易（上海）有限公司 | Hair follicle nutrient liquor composition and preparation method thereof |
| CN107224421A (en) * | 2017-07-20 | 2017-10-03 | 唐少钦 | A kind of Chinese herbal medicine oil-control anticreep shampoo and preparation method |
-
2018
- 2018-07-16 CN CN201810775424.3A patent/CN110721125A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090143714A1 (en) * | 2007-11-29 | 2009-06-04 | Cheri Lynn Millikin | Regulation of Mammalian Keratinous Tissue Using Skin and/or Hair Care Actives |
| CN104436118A (en) * | 2014-11-18 | 2015-03-25 | 天津钧濡科技有限公司 | Anti-dropping hair restoring liquid |
| CN106214592A (en) * | 2016-09-09 | 2016-12-14 | 美萃国际贸易（上海）有限公司 | Hair follicle nutrient liquor composition and preparation method thereof |
| CN107224421A (en) * | 2017-07-20 | 2017-10-03 | 唐少钦 | A kind of Chinese herbal medicine oil-control anticreep shampoo and preparation method |
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Application publication date: 20200124 |