CN102366389B - Preparation method for compound mosquito repelling and itching relieving floral water - Google Patents
Preparation method for compound mosquito repelling and itching relieving floral water Download PDFInfo
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- CN102366389B CN102366389B CN 201110338365 CN201110338365A CN102366389B CN 102366389 B CN102366389 B CN 102366389B CN 201110338365 CN201110338365 CN 201110338365 CN 201110338365 A CN201110338365 A CN 201110338365A CN 102366389 B CN102366389 B CN 102366389B
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Abstract
The invention discloses a preparation method for compound mosquito repelling and itching relieving floral water. The method comprises the following steps: preparing, by weight, 10 to 35 parts of orange blossom, 10 to 25 parts of tarragon, 10 tor 45 parts of sweet wormwood leaf, 10 to 35 parts of lavender, 10 to 35 parts of lemongrass, 10 to 25 parts of mint, 10 to 35 parts of yellow willow herb and 5 to 25 parts of cicada slough; crushing orange flower, tarragon, sweet wormwood leaf, lavender, lemongrass and mint together, extracting plant essential oil from an obtained mixture by using supercritical carbon dioxide, crushing yellow willow herb and cicada slough together, carrying out extraction on an obtained mixture of yellow willow herb and cicada slough by using the percolation method, standing an obtained extract for more than 48 hours, taking a supernatant of the extract, and evenly mixing the supernatant with the plant essential oil obtained in supercritical carbon dioxide extraction so as to prepare a solution preparation of the floral water. The solution preparation has the advantages of strong mosquito poisoning and repelling capability, good effects in diminishing swelling and relieving itching, safety, no toxic and side effects, good stability and small possibility in generation of drug resistance.
Description
Technical field
The invention belongs to field of traditional Chinese, specifically, relate to a kind of preparation method of compound recipe mosquito-expelling and antipruritic floral water.
Background technology
Mosquito sucks human blood, can propagate such as diseases such as malaria, filaricide, epidemic encephalitis type B and dengue fever, has caused serious public health problem.For a long time, people seek several different methods control mosquito, some chemical insecticides that used are effective to mosquito control, and efficiency time is long, such as DEET(N, the N-diethyl-m-methyl benzamide), in the sick control of the mosquito matchmaker in a lot of areas, plays the important and pivotal role, in people's daily life, also play irreplaceable effect.
Along with in the past a large amount of uses of five more than ten years of insecticide, the Drug resistance of mosquito is more and more stronger, causes the quantity of mosquito to be growing on and on, and natural environment and ecological balance is also exerted an influence, and use a large amount of DEET will produce toxic and side effects.Therefore seek effective to mosquito control, killing ability strong, the insecticide that has no side effect, be difficult for developing immunity to drugs is very urgent.Plants essential oil is a class time natural disposition metabolite in the plant, and main component is monoterpene, sesquiterpene and aromatic hydrocarbon derivative.Many plants essential oils have certain poisoning and repellent effect to mosquito, and plants essential oil has aromatic odor, therefore can use it for mosquito control or therefrom seek the natural template of synthetic.
Summary of the invention
For solving above technical problem, the object of the present invention is to provide a kind of compound recipe mosquito-expelling and antipruritic floral water of, safe without toxic side effect effective to mosquito control.
The present invention seeks to realize like this:
Concrete preparation process of the present invention is as follows:
(1) joins by weight and get 10～35 parts of orange blossoms, 10～25 parts of Folium Artemisiae Argyis, 10～45 parts of artemisia leafs, 10～35 parts of lavandula angustifoliaes, 10～35 parts in Herba Cymbopogonis Citrari, 10～25 parts of Herba Menthaes, 10～35 parts of American lotus, 5～25 parts of Periostracum Cicadaes;
(2) orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are pulverized in the lump, use supercritical carbon dioxide extraction, obtain its plants essential oil, for subsequent use;
(3) American lotus, Periostracum Cicadae are pulverized in the lump, carry out the percolation extraction with ethanol as leaching solvent, extracting solution was left standstill more than 48 hours, it is for subsequent use to get supernatant;
(4) the even mixing of the supernatant in the plants essential oil in the step (2) and the step (3) made solution.
Above-mentioned orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae, American lotus, Periostracum Cicadae all are dry product.
Above-mentioned steps is crushed to 30～60 orders in the lump with orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae in (2).
Above-mentioned steps is crushed to 30～60 orders in the lump with American lotus, Periostracum Cicadae in (3).
Leaching the solvent concentration of alcohol in the above-mentioned steps (4) is 75%.
Herba lysimachiae davuricae is the flower and alabastrum that Rhizoma Coptidis has just been bursted forth, and Herba Cymbopogonis Citrari is the grass family Cymbopogon plants, lavandula angustifolia normal operation inflorescence, and orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae, American lotus, Periostracum Cicadae are dry product all, are generally and dry in the shade.
For showing therapeutic effect of the present invention, the present invention obtains following laboratory report through clinical trial:
Mosquito is prepared in experiment: by the mosquito larvae of adopting back in the cloudy well in local district, through being accredited as culex pipiens pallens, the laboratory artificial breeding sprouted wings rear 3～5 days until it, isolated female mosquito, moved in the mosquito cage of 30cm * 30cm * 40cm 300 in every cage.
The preparation of laboratory sample:
(1) product of producing by the present invention is the sample I.
(2) with N, the N-diethyl-m-methyl benzamide is main component, contains N take concentration as 75% ethanol as solvent makes, and N-diethyl-m-methyl benzamide concentration is that 5% floral water is the sample II.
(3) take commercially available " six refreshing mosquito-repellent perfumes " as the sample III.
The volunteer selects: 24 of volunteers, and the men and women half and half, and quantity of sample handling be the about 0.15ml/ square centimeter of experimenter's the back of the hand, after the processing hands is stretched into per hour to expose 5min in the mosquito cage, and observation 6h records the mosquito bite number of times and also calculates Effective Vate of Protection.
In Effective Vate of Protection=this time effectively inductor number/dispenser inductor sum * 100% (effectively the inductor number refers to not by the inductor quantity of mosquito bite, and inductor is subjected to first mosquito bite namely to be considered as inductor to lose efficacy.）
More than experiment all began to carry out 26 ℃～31 ℃ of temperature, humidity 40%～55%, dim light 6: 30 evening.Take staff as inductor; observe the repelling effect of each sample; it is 26.5 times at the average mosquito bite number of the every 5min of every hands before sample treatment; none was subjected to mosquito bite in the 6h after sample II and sample I were processed; this protective rate of 2 groups is 100%, and (the sample I is compared with the sample II; through t check, P＞0.05, there was no significant difference).After the sample III is processed, have 5 inductors to lose efficacy in the 6h, be subjected to mosquito bite average time be 4.7 times, protective rate is 79% (the sample III is compared with the sample II, checks through t, and there is significant difference P＜0.05).
Experimental results show that the product produced by the present invention and contain N that N-diethyl-m-methyl benzamide concentration is that 5% floral water repelling effect is suitable, and is more satisfactory for result than " six refreshing mosquito-repellent perfumes ".
Beneficial effect: product of the present invention and N, N-diethyl-m-methyl benzamide have good poisoning anophelifuge ability, repellent antipruritic effect.This product is Chinese herbal compounds, safe without toxic side effect, and good stability is difficult for developing immunity to drugs, nonirritant, injured skin not, plants essential oil has the natural aromatic abnormal smells from the patient.
The specific embodiment
Embodiment 1
Join by weight and get 10 parts of orange blossoms, 10 parts of Folium Artemisiae Argyis, 10 parts of artemisia leafs, 10 parts of lavandula angustifoliaes, 10 parts in Herba Cymbopogonis Citrari, 10 parts of Herba Menthaes, 10 parts of American lotus, 5 parts of Periostracum Cicadaes; Orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are crushed to 30 orders in the lump, use again supercritical carbon dioxide extraction, obtain its plants essential oil; American lotus, Periostracum Cicadae are crushed to 30 orders in the lump, carry out percolation and extract as leaching solvent take the ethanol of concentration as 75%, extracting solution was left standstill 48 hours, it is for subsequent use to get supernatant; The plants essential oil that again supernatant and supercritical extraction is obtained evenly mixes and makes solution.
Embodiment 2
Join by weight and get 35 parts of orange blossoms, 25 parts of Folium Artemisiae Argyis, 45 parts of artemisia leafs, 35 parts of lavandula angustifoliaes, 35 parts in Herba Cymbopogonis Citrari, 25 parts of Herba Menthaes, 35 parts of American lotus, 25 parts of Periostracum Cicadaes; Orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are crushed to 60 orders in the lump, use again supercritical carbon dioxide extraction, obtain its plants essential oil; American lotus, Periostracum Cicadae are crushed to 60 orders in the lump, carry out percolation and extract as leaching solvent take the ethanol of concentration as 75%, extracting solution was left standstill 50 hours, it is for subsequent use to get supernatant; The plants essential oil that again supernatant and supercritical extraction is obtained evenly mixes and makes solution.
Embodiment 3
Join by weight and get 20 parts of orange blossoms, 20 parts of Folium Artemisiae Argyis, 25 parts of artemisia leafs, 20 parts of lavandula angustifoliaes, 20 parts in Herba Cymbopogonis Citrari, 15 parts of Herba Menthaes, 20 parts of American lotus, 15 parts of Periostracum Cicadaes; Orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are crushed to 50 orders in the lump, use again supercritical carbon dioxide extraction, obtain its plants essential oil; American lotus, Periostracum Cicadae are crushed to 50 orders in the lump, carry out percolation and extract as leaching solvent take the ethanol of concentration as 75%, extracting solution was left standstill 55 hours, it is for subsequent use to get supernatant; The plants essential oil that again supernatant and supercritical extraction is obtained evenly mixes and makes solution.
Claims (5)
1. the preparation method of a compound recipe mosquito-expelling and antipruritic floral water is characterized in that carrying out as follows:
(1) joins by weight and get 10～35 parts of orange blossoms, 10～25 parts of Folium Artemisiae Argyis, 10～45 parts of artemisia leafs, 10～35 parts of lavandula angustifoliaes, 10～35 parts in Herba Cymbopogonis Citrari, 10～25 parts of Herba Menthaes, 10～35 parts of American lotus, 5～25 parts of Periostracum Cicadaes;
(2) orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are pulverized in the lump, use supercritical carbon dioxide extraction, obtain its plants essential oil, for subsequent use;
(3) American lotus, Periostracum Cicadae are pulverized in the lump, carry out the percolation extraction with ethanol as leaching solvent, extracting solution was left standstill more than 48 hours, it is for subsequent use to get supernatant;
(4) the even mixing of the supernatant in the plants essential oil in the step (2) and the step (3) made solution;
Described American lotus is the flower and alabastrum that Rhizoma Coptidis has just been bursted forth.
2. the preparation method of described compound recipe mosquito-expelling and antipruritic floral water according to claim 1, it is characterized in that: described orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae, American lotus, Periostracum Cicadae all are dry product.
3. the preparation method of described compound recipe mosquito-expelling and antipruritic floral water according to claim 1, it is characterized in that: described step is crushed to 30～60 orders in the lump with orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae in (2).
4. the preparation method of described compound recipe mosquito-expelling and antipruritic floral water according to claim 1, it is characterized in that: described step is crushed to 30～60 orders in the lump with American lotus, Periostracum Cicadae in (3).
5. the preparation method of described compound recipe mosquito-expelling and antipruritic floral water according to claim 1, it is characterized in that: leaching the solvent concentration of alcohol in the described step (4) is 75%.
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| CN 201110338365 CN102366389B (en) | 2011-11-01 | 2011-11-01 | Preparation method for compound mosquito repelling and itching relieving floral water |
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| CN 201110338365 CN102366389B (en) | 2011-11-01 | 2011-11-01 | Preparation method for compound mosquito repelling and itching relieving floral water |
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| CN102366389B true CN102366389B (en) | 2013-03-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478473A (en) * | 2018-05-17 | 2018-09-04 | 东莞市卫花生物科技有限公司 | Mosquito-proof antimicrobial fluid |
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| CN103830131A (en) * | 2012-11-27 | 2014-06-04 | 顾月燕 | Preparation method of floral water for children |
| CN103622867B (en) * | 2013-06-30 | 2015-04-01 | 金玛瑙香水（明光）有限公司 | Method for preparing mosquito-repellent perfume containing natural plant essential oil |
| CN103948527A (en) * | 2014-04-30 | 2014-07-30 | 卜明珍 | Chinese medicinal compound mosquito-repellent floral water |
| CN103989595B (en) * | 2014-04-30 | 2016-04-13 | 卜明珍 | A kind of natural florida water for children |
| CN104274634B (en) * | 2014-08-14 | 2018-01-05 | 杭州方回春堂国药馆有限公司 | It is a kind of to refresh the mind and the compound plant essential oil of repellent antipruritic and preparation method thereof |
| CN106265262A (en) * | 2016-08-25 | 2017-01-04 | 周荣 | A kind of preparation method of natural cosmetic water |
| CN106419443A (en) * | 2016-09-22 | 2017-02-22 | 广西棕海园林工程有限公司 | Antibacterial carpet |
| CN106309987B (en) * | 2016-10-13 | 2020-02-07 | 海南娜古芳沉香科技有限公司 | Composition, floral water containing composition and application of floral water |
| CN106726871A (en) * | 2016-11-18 | 2017-05-31 | 重庆市日用化学工业研究所 | Sweet wormwood mosquito-expelling and antipruritic floral water and preparation method thereof |
| CN108498378A (en) * | 2018-04-19 | 2018-09-07 | 厦门千鹰生物科技有限公司 | A kind of mosquito repellent, antipruritic, detumescence compound plant essential oil and its application |
| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
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| CN101268990A (en) * | 2008-05-07 | 2008-09-24 | 广州市拜澳生物科技有限公司 | Condensation type floral water and preparation method thereof |
| CN101461771A (en) * | 2009-01-06 | 2009-06-24 | 天津郁美净集团有限公司 | Nonalcoholic Chinese medicine cologne water and method for producing the same |
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| CN108478473A (en) * | 2018-05-17 | 2018-09-04 | 东莞市卫花生物科技有限公司 | Mosquito-proof antimicrobial fluid |
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