CN102366389A - Preparation method for compound mosquito repelling and itching relieving floral water - Google Patents
Preparation method for compound mosquito repelling and itching relieving floral water Download PDFInfo
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- CN102366389A CN102366389A CN2011103383651A CN201110338365A CN102366389A CN 102366389 A CN102366389 A CN 102366389A CN 2011103383651 A CN2011103383651 A CN 2011103383651A CN 201110338365 A CN201110338365 A CN 201110338365A CN 102366389 A CN102366389 A CN 102366389A
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Abstract
The invention discloses a preparation method for compound mosquito repelling and itching relieving floral water. The method comprises the following steps: preparing, by weight, 10 to 35 parts of orange blossom, 10 to 25 parts of tarragon, 10 tor 45 parts of sweet wormwood leaf, 10 to 35 parts of lavender, 10 to 35 parts of lemongrass, 10 to 25 parts of mint, 10 to 35 parts of yellow willow herb and 5 to 25 parts of cicada slough; crushing orange flower, tarragon, sweet wormwood leaf, lavender, lemongrass and mint together, extracting plant essential oil from an obtained mixture by using supercritical carbon dioxide, crushing yellow willow herb and cicada slough together, carrying out extraction on an obtained mixture of yellow willow herb and cicada slough by using the percolation method, standing an obtained extract for more than 48 hours, taking a supernatant of the extract, and evenly mixing the supernatant with the plant essential oil obtained in supercritical carbon dioxide extraction so as to prepare a solution preparation of the floral water. The solution preparation has the advantages of strong mosquito poisoning and repelling capability, good effects in diminishing swelling and relieving itching, safety, no toxic and side effects, good stability and small possibility in generation of drug resistance.
Description
Technical field
The invention belongs to field of traditional Chinese, specifically, relate to a kind of method for preparing of compound recipe mosquito-expelling and antipruritic floral water.
Background technology
Mosquito sucks human blood, can propagate like diseases such as malaria, filaricide, epidemic encephalitis type B and dengue fever, has caused serious public health problem.For a long time; People seek several different methods control mosquito, and more already used chemical insecticides are effective to mosquito control, and efficiency time is long; Like DEET (N; The N-diethyl-m-methyl benzamide), in the sick control of a lot of geographic mosquito matchmakers, plays the important and pivotal role, in people's daily life, also play irreplaceable effect.
Along with insecticide a large amount of uses of five more than ten years in the past, the Drug resistance of mosquito is more and more stronger, causes the quantity of mosquito to be growing on and on, and natural environment and ecological balance is also exerted an influence, and use a large amount of DEET will produce toxic and side effects.Therefore seek effective to mosquito control, killing ability strong, the insecticide that has no side effect, be difficult for developing immunity to drugs is very urgent.Plants essential oil is intravital one type the natural disposition metabolite of plant, and main component is monoterpene, sesquiterpene and aromatic hydrocarbon derivative.Many plants essential oils have certain poisoning and repellent effect to mosquito, and plants essential oil has aromatic odor, therefore can use it for mosquito control or therefrom seek the natural template of synthetic.
Summary of the invention
For solving above technical problem, the object of the present invention is to provide a kind of compound recipe mosquito-expelling and antipruritic floral water of, safe without toxic side effect effective to mosquito control.
The present invention seeks to realize like this:
Concrete preparation process of the present invention is following:
(1) joins by weight and get 10～35 parts of orange blossoms, 10～25 parts of Folium Artemisiae Argyis, 10～45 parts of artemisia leafs, 10～35 parts of lavandula angustifoliaes, 10～35 parts in Herba Cymbopogonis Citrari, 10～25 parts of Herba Menthaes, 10～35 parts of American lotus, 5～25 parts of Periostracum Cicadaes;
(2) orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are pulverized in the lump, use supercritical carbon dioxide extraction, obtain its plants essential oil, subsequent use;
(3) American lotus, Periostracum Cicadae are pulverized in the lump, carry out the percolation extraction with ethanol as leaching solvent, extracting solution was left standstill more than 48 hours, it is subsequent use to get supernatant;
(4) the supernatant uniform mixing in plants essential oil in the step (2) and the step (3) is made solution.
Above-mentioned orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae, American lotus, Periostracum Cicadae all are dry product.
Above-mentioned steps is crushed to 30～60 orders with orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae in (2) in the lump.
Above-mentioned steps is crushed to 30～60 orders with American lotus, Periostracum Cicadae in (3) in the lump.
Leaching the solvent concentration of alcohol in the above-mentioned steps (4) is 75%.
Herba lysimachiae davuricae is the flower and alabastrum that Rhizoma Coptidis has just been bursted forth, and Herba Cymbopogonis Citrari is grass family Cymbopogon plant, and lavandula angustifolia generally uses inflorescence, and orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae, American lotus, Periostracum Cicadae are dry product all, are generally and dry in the shade.
For showing therapeutic effect of the present invention, the present invention obtains following laboratory report through clinical trial:
Mosquito is prepared in experiment: by the mosquito larvae of adopting back in the cloudy well in local district, through being accredited as culex pipiens pallens, the laboratory artificial breeding treated its emergence back 3～5 days, isolated female mosquito, moved in the mosquito cage of 30cm * 30cm * 40cm 300 in every cage.
The preparation of laboratory sample:
(1) be the sample I by the product that the present invention produced.
(2) with N, the N-diethyl-m-methyl benzamide is a main component, is that 75% ethanol is that solvent makes and contains N with concentration, and N-diethyl-m-methyl benzamide concentration is that 5% floral water is the sample II.
(3) be the sample III with commercially available " six refreshing mosquito-repellent perfumes ".
The volunteer selects: 24 of volunteers, and the men and women half and half, and quantity of sample handling be the about 0.15ml/ square centimeter of experimenter's the back of the hand, after the processing hands is stretched into per hour to expose 5min in the mosquito cage, and observation 6h writes down the mosquito bite number of times and also calculates Effective Vate of Protection.
In Effective Vate of Protection=this time effectively inductor number/dispenser inductor sum * 100% (effectively the inductor number is meant not by the inductor quantity of mosquito bite, and inductor receives first mosquito bite promptly to be regarded as inductor to lose efficacy.）
More than experiment all began to carry out 26 ℃～31 ℃ of temperature, humidity 40%～55%, dim light 6: 30 evening.With the staff is inductor; Observing the repelling effect of each sample, is 26.5 times at the average mosquito bite number of the every 5min of every hands before sample treatment, and none received mosquito bite in the 6h after sample II and sample I were handled; This protective rate of 2 groups is 100%, and (the sample I is compared with the sample II; Through t check, P＞0.05, there was no significant difference).In the sample III is handled back 6h, have 5 inductors to lose efficacy, receive mosquito bite average time be 4.7 times, protective rate is 79% (the sample III is compared with the sample II, checks through t, and there is significant difference P＜0.05).
Experiment proof by product that the present invention produced with contain N, N-diethyl-m-methyl benzamide concentration is that 5% floral water repelling effect is suitable, and is more satisfactory for result than " six refreshing mosquito-repellent perfumes ".
Beneficial effect: product of the present invention and N, N-diethyl-m-methyl benzamide have good poisoning anophelifuge ability, repellent antipruritic effect.This product is the Chinese medicine complex, safe without toxic side effect, and good stability is difficult for developing immunity to drugs, nonirritant, injured skin not, plants essential oil has the natural aromatic abnormal smells from the patient.
The specific embodiment
Embodiment 1
Join by weight and get 10 parts of orange blossoms, 10 parts of Folium Artemisiae Argyis, 10 parts of artemisia leafs, 10 parts of lavandula angustifoliaes, 10 parts in Herba Cymbopogonis Citrari, 10 parts of Herba Menthaes, 10 parts of American lotus, 5 parts of Periostracum Cicadaes; Orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are crushed to 30 orders in the lump, and the reuse supercritical carbon dioxide extraction obtains its plants essential oil; American lotus, Periostracum Cicadae are crushed to 30 orders in the lump, are that 75% ethanol carries out the percolation extraction as leaching solvent with concentration, and extracting solution was left standstill 48 hours, and it is subsequent use to get supernatant; The plants essential oil uniform mixing that obtains supernatant and supercritical extraction again makes solution.
Embodiment 2
Join by weight and get 35 parts of orange blossoms, 25 parts of Folium Artemisiae Argyis, 45 parts of artemisia leafs, 35 parts of lavandula angustifoliaes, 35 parts in Herba Cymbopogonis Citrari, 25 parts of Herba Menthaes, 35 parts of American lotus, 25 parts of Periostracum Cicadaes; Orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are crushed to 60 orders in the lump, and the reuse supercritical carbon dioxide extraction obtains its plants essential oil; American lotus, Periostracum Cicadae are crushed to 60 orders in the lump, are that 75% ethanol carries out the percolation extraction as leaching solvent with concentration, and extracting solution was left standstill 50 hours, and it is subsequent use to get supernatant; The plants essential oil uniform mixing that obtains supernatant and supercritical extraction again makes solution.
Embodiment 3
Join by weight and get 20 parts of orange blossoms, 20 parts of Folium Artemisiae Argyis, 25 parts of artemisia leafs, 20 parts of lavandula angustifoliaes, 20 parts in Herba Cymbopogonis Citrari, 15 parts of Herba Menthaes, 20 parts of American lotus, 15 parts of Periostracum Cicadaes; Orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are crushed to 50 orders in the lump, and the reuse supercritical carbon dioxide extraction obtains its plants essential oil; American lotus, Periostracum Cicadae are crushed to 50 orders in the lump, are that 75% ethanol carries out the percolation extraction as leaching solvent with concentration, and extracting solution was left standstill 55 hours, and it is subsequent use to get supernatant; The plants essential oil uniform mixing that obtains supernatant and supercritical extraction again makes solution.
Claims (5)
1. the method for preparing of a compound recipe mosquito-expelling and antipruritic floral water is characterized in that carrying out as follows:
(1) joins by weight and get 10～35 parts of orange blossoms, 10～25 parts of Folium Artemisiae Argyis, 10～45 parts of artemisia leafs, 10～35 parts of lavandula angustifoliaes, 10～35 parts in Herba Cymbopogonis Citrari, 10～25 parts of Herba Menthaes, 10～35 parts of American lotus, 5～25 parts of Periostracum Cicadaes;
(2) orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae are pulverized in the lump, use supercritical carbon dioxide extraction, obtain its plants essential oil, subsequent use;
(3) American lotus, Periostracum Cicadae are pulverized in the lump, carry out the percolation extraction with ethanol as leaching solvent, extracting solution was left standstill more than 48 hours, it is subsequent use to get supernatant;
(4) the supernatant uniform mixing in plants essential oil in the step (2) and the step (3) is made solution.
2. according to the method for preparing of the said compound recipe mosquito-expelling and antipruritic of claim 1 floral water, it is characterized in that: said orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae, American lotus, Periostracum Cicadae all are dry product.
3. according to the method for preparing of the said compound recipe mosquito-expelling and antipruritic of claim 1 floral water, it is characterized in that: said step is crushed to 30～60 orders with orange blossom, Folium Artemisiae Argyi, artemisia leaf, lavandula angustifolia, Herba Cymbopogonis Citrari, Herba Menthae in (2) in the lump.
4. according to the method for preparing of the said compound recipe mosquito-expelling and antipruritic of claim 1 floral water, it is characterized in that: said step is crushed to 30～60 orders with American lotus, Periostracum Cicadae in (3) in the lump.
5. according to the method for preparing of the said compound recipe mosquito-expelling and antipruritic of claim 1 floral water, it is characterized in that: leaching the solvent concentration of alcohol in the said step (4) is 75%.
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| CN 201110338365 CN102366389B (en) | 2011-11-01 | 2011-11-01 | Preparation method for compound mosquito repelling and itching relieving floral water |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622867A (en) * | 2013-06-30 | 2014-03-12 | 金玛瑙香水（明光）有限公司 | Method for preparing mosquito-repellent perfume containing natural plant essential oil |
| CN103830131A (en) * | 2012-11-27 | 2014-06-04 | 顾月燕 | Preparation method of floral water for children |
| CN103948527A (en) * | 2014-04-30 | 2014-07-30 | 卜明珍 | Chinese medicinal compound mosquito-repellent floral water |
| CN103989595A (en) * | 2014-04-30 | 2014-08-20 | 卜明珍 | Natural children florida water |
| CN104274634A (en) * | 2014-08-14 | 2015-01-14 | 杭州方回春堂国药馆有限公司 | Compound plant essential oil for refreshing, restoring consciousness, diminishing swelling and relieving itching and preparation method of compound plant essential oil |
| CN106265262A (en) * | 2016-08-25 | 2017-01-04 | 周荣 | A kind of preparation method of natural cosmetic water |
| CN106309987A (en) * | 2016-10-13 | 2017-01-11 | 杨锦玲 | Composition, floral water containing composition and application thereof |
| CN106419443A (en) * | 2016-09-22 | 2017-02-22 | 广西棕海园林工程有限公司 | Antibacterial carpet |
| CN106726871A (en) * | 2016-11-18 | 2017-05-31 | 重庆市日用化学工业研究所 | Sweet wormwood mosquito-expelling and antipruritic floral water and preparation method thereof |
| CN108498378A (en) * | 2018-04-19 | 2018-09-07 | 厦门千鹰生物科技有限公司 | A kind of mosquito repellent, antipruritic, detumescence compound plant essential oil and its application |
| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108478473A (en) * | 2018-05-17 | 2018-09-04 | 东莞市卫花生物科技有限公司 | Mosquito-proof antimicrobial fluid |
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| CN101268990A (en) * | 2008-05-07 | 2008-09-24 | 广州市拜澳生物科技有限公司 | Condensation type floral water and preparation method thereof |
| CN101461771A (en) * | 2009-01-06 | 2009-06-24 | 天津郁美净集团有限公司 | Nonalcoholic Chinese medicine cologne water and method for producing the same |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830131A (en) * | 2012-11-27 | 2014-06-04 | 顾月燕 | Preparation method of floral water for children |
| CN103622867A (en) * | 2013-06-30 | 2014-03-12 | 金玛瑙香水（明光）有限公司 | Method for preparing mosquito-repellent perfume containing natural plant essential oil |
| CN103948527A (en) * | 2014-04-30 | 2014-07-30 | 卜明珍 | Chinese medicinal compound mosquito-repellent floral water |
| CN103989595A (en) * | 2014-04-30 | 2014-08-20 | 卜明珍 | Natural children florida water |
| CN104274634A (en) * | 2014-08-14 | 2015-01-14 | 杭州方回春堂国药馆有限公司 | Compound plant essential oil for refreshing, restoring consciousness, diminishing swelling and relieving itching and preparation method of compound plant essential oil |
| CN106265262A (en) * | 2016-08-25 | 2017-01-04 | 周荣 | A kind of preparation method of natural cosmetic water |
| CN106419443A (en) * | 2016-09-22 | 2017-02-22 | 广西棕海园林工程有限公司 | Antibacterial carpet |
| CN106309987A (en) * | 2016-10-13 | 2017-01-11 | 杨锦玲 | Composition, floral water containing composition and application thereof |
| CN106726871A (en) * | 2016-11-18 | 2017-05-31 | 重庆市日用化学工业研究所 | Sweet wormwood mosquito-expelling and antipruritic floral water and preparation method thereof |
| CN108498378A (en) * | 2018-04-19 | 2018-09-07 | 厦门千鹰生物科技有限公司 | A kind of mosquito repellent, antipruritic, detumescence compound plant essential oil and its application |
| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
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| CN102366389B (en) | 2013-03-20 |
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