CN105878530A - Air freshening bacteriostatic agent and preparation method thereof - Google Patents
Air freshening bacteriostatic agent and preparation method thereof Download PDFInfo
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- CN105878530A CN105878530A CN201610367616.1A CN201610367616A CN105878530A CN 105878530 A CN105878530 A CN 105878530A CN 201610367616 A CN201610367616 A CN 201610367616A CN 105878530 A CN105878530 A CN 105878530A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses an air freshening bacteriostatic agent. The air freshening bacteriostatic agent is prepared by mixing 11-25 parts by weight of Mussaenda philippica, 5-15 parts by weight of honeysuckle, 5-9 parts by weight of Morinda officinalis, 3-9 parts by weight of herba houttuyniae and 2-5 parts by weight of Chengkou Mahonia, conducting displacement extraction with an ethyl alcohol solution, conducting centrifugation to remove grease, conducting refined filtration to remove sediment, and collecting refined filtration liquid and conducting filling. The air freshening bacteriostatic agent is prepared by selecting Yao medicines with fragrance and sterilizing and bacteriostatic effect as the raw material, can freshen air, dispel insects and remove mosquitoes and flies, kill mites and bacteria, prevent diseases and replace chemically-synthesized air freshener and insect aerosol, and can be widely used for automobile inner spaces, schools, living rooms, military places, hospitals, meeting rooms, cinemas, hotel lodges, supermarkets and other crowded places frequent in population mobility and prone to cross infection.
Description
Technical field
The present invention relates to a kind of air fresh bacteriostat, particularly relate to a kind of extraction with precious jade medical material for raw material and join
Air fresh bacteriostat put and preparation method thereof.
Background technology
The air freshener sold in the market and the insect aerosol repelled mosquitoes and flies contain big quantization mostly
Study point, human body is had certain toxicity.The most widely used indoor insecticidal aerosol, just contains one
Plant universally acknowledged safe pyrethroid insecticidal constituent.But test confirms, pyrethroid parasite killing
Agent has obvious toxicity to the nervous system of people and animals, and Long Term Contact can cause nervous system toxicity, causes god
Through nervous symptoms such as paralysis, sensory nerve exception and dizziness headaches.
Along with the high development of social material civilization, air pollution particularly room air pollution is day by day serious,
Cause respiratory tract disease prevalence increase severely and occur dizzy, tired feel sick etc. symptom, threaten human health.
How eliminating and to prevent room air pollution to become the focus of attention of masses, many producers have released one after another and have been permitted
The product of the most pure and fresh disinfecting air, but air freshener in the market also exists bigger problem: and one is exhausted
Most of air fresheners simply with the addition of perfume ingredient, only has aromatic odor and does not has sterilizing merit
Effect；Two is mostly with chemical plant product as raw material, causes air pollution；Though three is traditional medicine sterile products
So there is stronger disinfection effect, but often the smell is awful (such as lysol), or sterilize with fluoric acid, all
The air ambient of indoor can not be improved completely.
Therefore, expert advice, windowed ventilation by duty, carry out environment purification with fresh natural air, or select
From natural plants, effective component extracting makes novel air freshener to purify air.Extract from Chinese medicine and have
Effect composition makes the air freshener of high-efficiency environment friendly, still belongs to initiative industry project, pole on the outer market of Now Domestic
With prospects.Develop according to Yao nationality's folk tradition naturopathy, both there is opposing antibacterial and pathomycete
Effect, can prevent again the precious jade medicine air fresh bacteriostat of eczema, skin pruritus, scabies, not yet by commercially
Find.
Summary of the invention
Present invention aims to drawbacks described above of the prior art, it is provided that one is oozed with precious jade medicine for raw material
Filtering and extract formulated air fresh bacteriostat and preparation method thereof, the air fresh bacteriostat of the present invention was both
Energy fresh air, anthelmintic, except mosquitos and flies, mite killing sterilizing, can prevent again disease.
For achieving the above object, present invention employs following technical scheme:
Air fresh bacteriostat, is mainly made up of following raw material: blank sheet of paper fan, Flos Lonicerae, Radix Morindae Officinalis, fish raw meat
Grass, Mahonia shenii Chun.
Above-mentioned air fresh bacteriostat, is made up of the raw material of following parts by weight: 11～25 parts of blank sheet of paper fans；5～
15 portions of Flos Loniceraes；5～9 parts of Radix Morindae Officinalis；3～9 parts of Herba Houttuyniae；2～5 parts of Mahonia shenii Chun.
Above-mentioned air fresh bacteriostat with the addition of the raw material of following parts by weight and makes: 0.1～1 part of Borneolum Syntheticum；1～
5 portions of Herba Menthaes；2～5 parts of Herba Lysimachiae foenum-graeci.
Above-mentioned air fresh bacteriostat with the addition of the raw material of following parts by weight and makes: 10～25 parts of Piao Xuan.
Above-mentioned air fresh bacteriostat is spray.
The preparation method of above-mentioned air fresh bacteriostat: each component raw material is mixed according to described parts by weight,
Carrying out seepage pressure effects, then centrifugal segregation grease with ethanol solution, fine straining removes precipitation, fills after collecting fine straining liquid
Dress is made.
The preparation method of above-mentioned air fresh bacteriostat comprises the following steps:
(1) pretreatment of raw material: each component raw material is gone silt, the removal of impurity, cleans up, section, dry
Or dry, standby；
(2) normal pressure percolation: after described raw material appropriateness is pulverized, be placed in percolator, top constantly add
75% ethanol solution, ethanol solution oozed during medical material sulfate layer flows downhill is moved and leached medicinal ingredient, collected percolate；
(3) centrifugal: percolate centrifuge to be processed, collects centrifugal liquid；
(4) fine straining: centrifugal liquid ultrafilter is filtered, collects fine straining liquid；
(5) fill: fine straining liquid is carried out fill and get final product.
Percolation operating process in the preparation method of above-mentioned air fresh bacteriostat is:
(1) grinding medicinal materials: described raw material powder is broken into coarse powder or coarse powder；
(2) moistening medicated powder: by described raw material first with 75% alcohol steep moistening of 2 times amount, be allowed to the most swollen
Swollen, it is to avoid to expand at percolator Chinese medicine powder and result in blockage；
(3) medicated powder fitted tube: try to give a false impression the end place mat suitable rustless steel filter material bottom percolator, by swells
Medicated powder load by several times percolator, answer degree of tightness suitable, uniformly flatten, top filter paper or gauze cover, and
Add a small amount of weight, in case medicated powder floats during solubilizer；
(4) get rid of bubble: open percolate outlet piston, add from medicated powder top 75% ethanol solution to
Percolate flows out from outlet, 75% ethanol solution submergence medicated powder surface 5cm, closes percolate outlet；
(5) precious jade medicated powder dipping: dipping 24～48h, makes the 75% abundant diffusion of ethanol solution；
(6) percolation: opening percolate outlet reception and filter liquid, the liquid rate of outflow of filtering calculates with 1000g precious jade medical material,
Per minute 10～30ml percolation, percolation 10.00h～5.56h, during be continuously replenished 75% ethanol solution,
Make solvent submergence medicated powder all the time.
Arbitrary above-mentioned air fresh bacteriostat is used in atomization plant.
Compared to prior art, present invention have an advantage that
Precious jade medicine composition of the present invention selects the natural precious jade medicine that sterilization effect is good, and the air that effective component extracting is made is clear
New antibacterial, can fresh air, anthelmintic except mosquitos and flies, mite killing sterilizing, disease can be prevented again, and use
Afterwards to human non-toxic's evil.By precious jade prescription solution: full side wind laxative is double to be executed, and compatibility is reasonable, makes human body reach around
Break even state between environment and internal organs, antibacterial while, gather heat-clearing and toxic substances removing altogether, refreshment, change
Phlegm and relieving cough, circulation of qi promoting is antipruritic, and dispel the heat analgesic, and improving eyesight removing nebula dissipates wind heat；Refresh oneself；Throat；Rash；
Resolving depression, the merit of sterilization anophelifuge fly.Have a sleepless night crowd to evening, then have mind calming sedate, calm the nerves, and auxiliary treatment is various
The effect of insomnia.
Through the results show, the precious jade medicine product of the present invention is to staphylococcus aureus, Candida albicans, green
Pus bacillus, live demodicid mite, influenza virus, streptococcus pneumoniae, Hemolytic streptococcus, dysentery bacterium, vibrio cholera,
The harmful bacterias such as Bacillus typhi have powerful killing action, it is possible to effectively prevent influenza, popular lung
The generation of the epidemic diseases such as scorching, can substitute air freshener and the insect aerosol of chemosynthesis in the market,
It is widely used in vapour interior space, school, room, army, hospital, hotel, meeting room, cinema, wine
The crowd is dense for shop lodge, supermarket etc., flowing frequently, easily causes the place of cross infection.
Detailed description of the invention
Below in conjunction with embodiment, technical solution of the present invention is further non-limitingly described in detail.Wherein,
Precious jade medicine raw material used is as follows:
A blank sheet of paper fan (Mussaenda philippica Richard) main component is Hai Enxia glycoside unit A, Radix Mussaendae
Glycoside A, B, C, M.Also containing cupreol, stigmasterol, ursolic acid, caffeic acid, p-coumaric acid, Resina Ferulae
Acid, shanzhiside methyl ester.Gram negative bacteria, positive bacteria all there is obvious inhibitory action.At this precious jade prescription
In agent: blank sheet of paper fan genus wind medicine, heat-clearing and toxic substances removing, raw Feng, inducing diuresis and reducing edema, preventing phlegm from forming and stopping coughing, removing heat from blood expelling summer-heat, use
In pneumonia, anger breathes out (cough due to lung-heat), breathes out wheel (flu), with regard to port (gastroenteritis) etc..
B Flos Lonicerae (Lonicera japonica) main component in addition to containing chlorogenic acid and isochlorogenic acid, possibly together with
Iridoid glycoside driffractive ring meliatin, sweroside, meliatin, lognic acid, New iridoid glucoside；Caulis Hederae Sinensis
Sapogenin, oleanolic acid；Disacoside B；Fulvotomentoside first, α-helexin, nothing are suffered from
Sub-Saponin B, macranthoidin A,B, largeflower-like honeysuckle flower Saponin second, largeflower-like honeysuckle flower time saponin A, ash felt
Hairy honeysuckle time Saponin the second grade.Volatile oil is mainly containing linalool, Flos Lonicerae alcohol, geraniol, bata-phenethyl alcohol, benzene first
30 Multiple components such as alcohol, isodigeranyl flower alcohol, alpha-terpineol, eugenol.To various pathogens as golden yellow
Staphylococcus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, secondary wound
Cold bacillus etc. all has inhibitory action.In the prescription agent of this precious jade: belong to wind medicine, there is heat-clearing and toxic substances removing, cooling blood for hemostasis
Effect, be used for breathing out wheel (cold, fever), summer larynx vexed (laryngopharynx swelling and pain), slurry moth (tonsillitis), anger breathe out
(cough due to lung-heat), with regard to port (enteritis) etc..
C Radix Morindae Officinalis (Morinda officinalis How) is mainly containing iridoid, triterpene, steroidal, anthraquinone and Huang
Ketone, has obvious inhibiting effect to antibacterials such as staphylococcus aureus, bacillus pyocyaneus, streptococcus pneumoniae.At this precious jade
In prescription agent: belong to laxative, there is heat-clearing and toxic substances removing, detumescence of dispeling the wind.For pneumonia, anger breathes out (cough due to lung-heat),
Breathe out wheel (flu), with regard to port (enteritis) etc..
D Herba Houttuyniae (Houttuynia cordata Thunb) main component composition be decanoylacetaldehyde (i.e. houttuynine sodium bisulfite),
Lauryl aldehyde, methyln nonyl ketone, Flos Caryophylli alkene, linalool, borneol acetate, australene, camphene, myrcene
With (R)-4-isopropenyl-1-methyl-1-cyclohexene, methyl n nonyl ketone, capraldehyde, capric acid. flower, leaf, fruit all contain Quercetin, Cortex querci dentatae
Glycoside, Isoquercitrin, reynoutrin, hyperin, afzerin, globulariacitrin, still contain chlorogenic acid, Palmic acid,
Linoleic acid, oleic acid, cupreol and cordarine.Effective ingredient houttuynine sodium bisulfite test in vitro to micrococcus catarrhalis,
Hemophilus influenza, streptococcus pneumoniae, staphylococcus aureus have obvious inhibiting effect.In the prescription agent of this precious jade: belong to
Wind medicine.There is heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, spleen invigorating, inducing diuresis to remove edema.For anger tight (bronchitis), pump
Traitor pardons Kazakhstan (pneumonia), breathes out wheel (cold, fever), and lung abscess, with regard to port traitor (enteritis) etc..
E Mahonia shenii Chun (Mahonia bealei (Fort.) Carr.) main component be berberine, jateorhizine, coptisine and
Palmatines etc., experimental results demonstrate that it is to escherichia coli, staphylococcus aureus, Staphylococcus albus, change
Shape bacillus, anthrax bacillus etc. have obvious bacteriostasis.In the prescription agent of this precious jade: belong to wind and spray medicine of holding concurrently mutually.Tool
There are the effects such as heat-clearing and toxic substances removing, invigorating the spleen to arrest diarrhea, eliminating phlegm and removing dampness, detumescence hemostasis.For anger tight (bronchitis),
Pump pardons Kazakhstan (pneumonia cough), summer larynx vexed (pharyngitis), touches black (bacillary dysentery) etc..
F Borneolum Syntheticum (Dryobalanops), Borneolum Syntheticum, isoborneol and synthetic Borneolum Syntheticum to staphylococcus aureus,
Beta hemolytic streptococcus, Streptococcus viridans, streptococcus pneumoniae and escherichia coli etc., the most all have
Substantially antibacterial action, the antibacterial action of three is similar, and low concentration is antibacterial, and high concentration sterilizes.Borneol is to pig suddenly
Random vibrio also has inhibitory action.Having refreshment, circulation of qi promoting is antipruritic, refreshment medicine of having one's ideas straightened out；Heat radiation analgesic；
Improving eyesight removing nebula medicine, moreover it is possible to sterilization anophelifuge fly.
G Herba Menthae (Menthahaplocalyx) main component is levorotatory menthol, left-handed menthone, isomenthone,
The Mentholums such as pulegone, decyl acetate, menthyl acetate, rosmarinic acid have the strongest bactericidal action, d-
Mentholum is stronger than the bacteriostasis of 1-Mentholum.Heat-clearing and toxic substances removing, refreshment, dissipate wind heat；Refresh oneself；Profit
Throat；Rash；Resolving depression, moreover it is possible to sterilization anophelifuge fly.
H Herba Lysimachiae foenum-graeci (Lysimachia foenum-graecum Hance) herb contain volatile oil, organic acid, alkane,
Terpenoid, phenols etc..Main component has nonacosane, hentriacontane.Stigmasterol, stigmasterol-3-O-B-D-Portugal
Grape glucoside, a-spinasterol, 12-methyl tridecanoic acid, behenic acid, 16-methylheptadecanoic acid methyl ester,
Hexadecylic acid, heptadecanoic acid and cyclohexane-carboxylix acid.Can not only circulation of qi promoting, pain relieving, drive ascarid, moreover it is possible to sterilization
Anophelifuge fly.Cure mainly and emit headache；Laryngopharynx swelling and pain；Toothache；Distension and fullness of the chest and abdomen；Ascariasis.
G Piao Xuan (Poriacocos (Schw.) Wolf) main component is triterpenes: pachymic acid, 16 Alpha-hydroxy perforations
Acid, 3 beta-hydroxy-7,9 (11), 24-Pilus Caprae seu Ovis steroid triolefin-21-acid, pachymic acid methyl ester, 16 Alpha-hydroxy eburicoic acid first
Ester, 7,9 (11)-DHPA methyl ester, 16 α-trihydroxy-7,9 (11), 24 (31)-Pilus Caprae seu Ovis steroid triolefin-21-
Acid methyl ester, total triterpenes methyl ester, 3-hydrogenation pine Siberian cocklebur acid, eburicoic acid, dehydroeburicoic acid, Poria eo-acid A, B, C,
D、DM、AM.β-Amyrin acetas, 3 beta-hydroxy-16 α-acetoxyl group-7,9 (11), 24-Pilus Caprae seu Ovis steroid
Triolefin-21-acid and 7,9 (11) DHPAs.There is mind calming sedate, the effect calmed the nerves.Have a guilty conscience for treatment
Infantile convulsion, forgetful, insomnia, asthenia agitation, epilepsy, dysuria, restless.
Preparation method used comprises the following steps:
(1) pretreatment of raw material: each component raw material is gone silt, the removal of impurity, cleans up, section, dry
Or dry, standby；
(2) normal pressure percolation:
2.1 grinding medicinal materials: described raw material powder is broken into coarse powder or coarse powder；
2.2 moistening medicated powder: by the 75% alcohol steep moistening of 2 times amount of described raw material；
2.3 medicated powder fitted tubes: try to give a false impression the end place mat suitable rustless steel filter material bottom percolator, by swells
Medicated powder loads percolator by several times, answers degree of tightness suitable, uniformly flattens, and top filter paper or gauze cover, and add
A small amount of weight；
2.4 get rid of bubble: open the piston of percolate outlet, add 75% ethanol solution from medicated powder top to oozing
Liquid of filtering flows out from outlet, 75% ethanol solution submergence medicated powder surface 5cm, closes percolate outlet；
2.5 precious jade medicated powder dippings: dipping 24～48h；
2.6 percolation: opening percolate outlet reception and filter liquid, the liquid rate of outflow of filtering calculates with 1000g precious jade medical material,
Per minute 10～30ml percolation, percolation 10.00h～5.56h,
During be continuously replenished 75% ethanol solution, make solvent submergence medicated powder all the time.
(3) centrifugal: percolate centrifuge to be processed, collects centrifugal liquid；
(4) fine straining: centrifugal liquid ultrafilter is filtered, collects fine straining liquid；
(5) fill: fine straining liquid is carried out fill and get final product.
The detailed preparation method of following example is with reference to abovementioned steps.
Embodiment 1
As a example by producing 5 tons No. one precious jade medicine air fresh bacteriostat, get out precious jade medicine medical material according to following weight
Raw material: blank sheet of paper fan 391.2kg, Flos Lonicerae 177.4kg, Radix Morindae Officinalis 124kg, Herba Houttuyniae 141.8kg, wood
Rhizoma Coptidis 70.9kg.
To clean up, dried blank sheet of paper is fanned, Flos Lonicerae, Radix Morindae Officinalis, Herba Houttuyniae, Mahonia shenii Chun, mixing,
Break into coarse powder, add 75% ethanol 100L, seal, after infiltrating 24 hours under room temperature, open, medicated powder fitted tube,
After soaking 48 hours with 75% ethanol 500 again, with 75% ethanol normal pressure percolation, collect 5 tons of percolates, from
The heart, fine straining.
Regulating concentration of alcohol with pure water, make final concentration of alcohol reach 62%, fill, envelope bottle, it is qualified to check
After, packaging warehouse-in.
Embodiment 2
To produce as a example by 5T precious jade medicine air fresh bacteriostat, get out precious jade medicine medicinal raw material according to following weight:
Blank sheet of paper fan 391.2kg, Flos Lonicerae 177.4kg, Radix Morindae Officinalis 124kg, Herba Houttuyniae 141.8kg, Mahonia shenii Chun 70.9kg,
Borneolum Syntheticum 2kg, Herba Menthae 65.2kg, Herba Lysimachiae foenum-graeci 65.2kg.
To clean up, dried blank sheet of paper fan, Flos Lonicerae, Radix Morindae Officinalis, Herba Houttuyniae, Mahonia shenii Chun, Borneolum Syntheticum,
Herba Menthae, Herba Lysimachiae foenum-graeci.Mixing, breaks into coarse powder, adds 75% ethanol 100L, seals, and infiltrates 24 little under room temperature
Shi Hou, opens, medicated powder fitted tube, then after soaking 48 hours with 75% ethanol 500, oozes with 75% ethanol normal pressure
Filter, collect 5 tons of percolates, centrifugal, fine straining.
Regulating concentration of alcohol with pure water, make final concentration of alcohol reach 62%, fill, envelope bottle, inspection is closed
After lattice, packaging warehouse-in.
Embodiment 3
To produce as a example by 5 tons of precious jade medicine air fresh bacteriostats, get out precious jade medicine medicinal raw material according to following weight:
Blank sheet of paper fan 391.2kg, Flos Lonicerae 177.4kg, Radix Morindae Officinalis 124kg, Herba Houttuyniae 141.8kg, Mahonia shenii Chun 70.9kg,
Piao Xuan 326kg.
To clean up, dried blank sheet of paper is fanned, Flos Lonicerae, Radix Morindae Officinalis, Herba Houttuyniae, Mahonia shenii Chun, Piao Xuan,
Mixing, breaks into coarse powder, adds 75% ethanol 100L, seals, and after infiltrating 24 hours, opens, medicine under room temperature
Powder fitted tube, then after soaking 48 hours with 75% ethanol 500, with 75% ethanol normal pressure percolation, collect 5 tons and ooze
Filter liquid, centrifugal, fine straining.
Regulating concentration of alcohol with pure water, make final concentration of alcohol reach 62%, fill, envelope bottle, inspection is closed
After lattice, packaging warehouse-in.
Application example 1
In laboratory, use in " Pharmacopoeia of People's Republic of China version in 2015 " [antibacterial efficacy determinations]
Method test case 1, example 2 and the bactericidal effect of example 3 precious jade medicine air fresh bacteriostat, method: by following
The fresh cultured thing of single culture (such as staphylococcus aureus) is seeded in trypticase soy broth,
Cultivating 18～24 hours at 30～35 DEG C and wait omnidistance strict operation, as method measures, the result that sterilizes is as follows:
Table 1 bactericidal assay result
Embodiment 2 and 3 air fresh bacteriostat bactericidal assay result is similar to Example 1, does not repeats them here.
Application example 2
Drug study comparison of the present invention is carried out at a distance of four kindergartens of to five kilometer in certain city's air line distance,
Experimental group is Liang Ge bottom class each 30 3～the child of 4 years old of two kindergartens, and matched group is other two institutes
Liang Ge bottom class each 30 3～the child of 4 years old of kindergarten.Two class every days of experimental group are early, evening is in religion
Room respectively uses a deuterzooid precious jade medicine inhibitor with fresh air (embodiment 1 product), and one class of matched group uses pure
Water purification is as sterilization placebo, and another class does not the most use any air freshener.At the spring and summer that influenza is prevailing
Friendship, use two classes of the kindergarten of precious jade medicine air fresh bacteriostat of the present invention, 60 child no ones
Flu；And use pure water to have 11 children's flu as sterilization one class of placebo；The most no
Then there are 10 child's flu in one class.
Claims (8)
1. an air fresh bacteriostat, it is characterised in that be mainly made up of following raw material: blank sheet of paper fan, gold silver
Flower, Radix Morindae Officinalis, Herba Houttuyniae, Mahonia shenii Chun.
Air fresh bacteriostat the most according to claim 1, it is characterised in that by following parts by weight
Raw material is made: 11～25 parts of blank sheet of paper fans；5～15 portions of Flos Loniceraes；5～9 parts of Radix Morindae Officinalis；3～9
Part Herba Houttuyniae；2～5 parts of Mahonia shenii Chun.
Air fresh bacteriostat the most according to claim 2, it is characterised in that with the addition of following weight portion
The raw material of number is made: 0.1～1 part of Borneolum Syntheticum；1～5 portion of Herba Menthae；2～5 parts of Herba Lysimachiae foenum-graeci.
Air fresh bacteriostat the most according to claim 2, it is characterised in that with the addition of following weight portion
The raw material of number is made: 10～25 parts of Piao Xuan.
5. according to described air fresh bacteriostat arbitrary in Claims 1-4, it is characterised in that this air
Pure and fresh antibacterial is spray.
6. the preparation method of the arbitrary described air fresh bacteriostat of Claims 1-4, it is characterised in that: will
Each component raw material mixes according to described parts by weight, carries out seepage pressure effects with ethanol solution, then is centrifuged
Removing grease, fine straining removes precipitation, and after collecting fine straining liquid, fill is made.
The preparation method of air fresh bacteriostat the most according to claim 6, it is characterised in that include with
Lower step:
(1) pretreatment of raw material: each component raw material is gone silt, the removal of impurity, cleans up, section, dry
Or dry, standby；
(2) normal pressure percolation: after described raw material appropriateness is pulverized, be placed in percolator, top constantly add
75% ethanol solution, ethanol solution oozed during medical material sulfate layer flows downhill is moved and leached medicinal ingredient, collected percolate；
(3) centrifugal: percolate centrifuge to be processed, collects centrifugal liquid；
(4) fine straining: centrifugal liquid ultrafilter is filtered, collects fine straining liquid；
(5) fill: fine straining liquid is carried out fill and get final product.
The preparation method of air fresh bacteriostat the most according to claim 7, it is characterised in that described in ooze
Operating process of filtering is:
(1) grinding medicinal materials: described raw material powder is broken into coarse powder or coarse powder；
(2) moistening medicated powder: by the 75% alcohol steep moistening of 2 times amount of described raw material；
(3) medicated powder fitted tube: try to give a false impression the end place mat suitable rustless steel filter material bottom percolator, by swells
Medicated powder load by several times percolator, answer degree of tightness suitable, uniformly flatten, top filter paper or gauze cover, and
Add a small amount of weight；
(4) get rid of bubble: open percolate outlet piston, add from medicated powder top 75% ethanol solution to
Percolate flows out from outlet, 75% ethanol solution submergence medicated powder surface 5cm, closes percolate outlet；
(5) precious jade medicated powder dipping: dipping 24～48h；
(6) percolation: opening percolate outlet reception and filter liquid, the liquid rate of outflow of filtering calculates with 1000g precious jade medical material,
Per minute 10～30ml percolation, percolation 10.00h～5.56h, during be continuously replenished 75% ethanol solution,
Make solvent submergence medicated powder all the time.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108379537A (en) * | 2018-05-09 | 2018-08-10 | 丛念滋 | A kind of infant's invigorating the spleen to arrest diarrhea herbaceous plant drink |
| CN108606215A (en) * | 2018-05-09 | 2018-10-02 | 丛念滋 | A kind of infant's purging intense heat defaecation herbaceous plant drink |
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Application publication date: 20160824 |