CN108272696A - A kind of external preparation with mosquito-expelling and antipruritic - Google Patents
A kind of external preparation with mosquito-expelling and antipruritic Download PDFInfo
- Publication number
- CN108272696A CN108272696A CN201810334673.9A CN201810334673A CN108272696A CN 108272696 A CN108272696 A CN 108272696A CN 201810334673 A CN201810334673 A CN 201810334673A CN 108272696 A CN108272696 A CN 108272696A
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- Prior art keywords
- mosquito
- expelling
- external preparation
- antipruritic
- camphor
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of external preparation with mosquito-expelling and antipruritic, is made of following raw material：Water, ethyl alcohol, methyl propanediol, camphor, menthol, butanediol, ammonium acryloyl taurate/VP copolymer, Phenoxyethanol, citronella grass oil, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, Artemisinin, glycosphingolipids; compared with prior art, the present invention has following advantageous effect：Mosquito repellent, sterilization, anti-miliaria, antipruritic and other effects are had both, can directly use, be applied to skin surface, can also be further used for preparing cosmetics, such as being prepared into floral water or bath foam etc., can also be used as after shave lotion use.
Description
Technical field
The present invention is a kind of external preparation with mosquito-expelling and antipruritic, belongs to mosquito repellent technical field.
Background technology
Mainly it is added to chemically synthesized repellant such as Metadelphene in traditional cosmetics with repelling effect
(DEET), mosquitofugal oil (DMP) or citronellal etc. are smeared on the skin, form protective film, keep mosquito close.This addition
The advantages of repellant of chemical composition, is mainly suitble to outgoing outing or is used when taking a walk, and is the good of realization small range self-protection
Side；However, the repellant of this addition chemical composition is likely to result in skin mistake.
Invention content
In view of the deficienciess of the prior art, it is an object of the present invention to provide a kind of external preparation with mosquito-expelling and antipruritic, with solution
Certainly the problems mentioned above in the background art.
To achieve the goals above, the present invention is to realize by the following technical solutions：It is a kind of with mosquito-expelling and antipruritic
External preparation is made of following raw material：Water, ethyl alcohol, methyl propanediol, camphor, menthol, butanediol, acryloyldimethyl ox sulphur
Sour ammonium/VP copolymers, Phenoxyethanol, citronella grass oil, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri fruit
Extract, Artemisinin, glycosphingolipids.
Further, trunk, tree root, branch and the leaf for choosing 50 years or more camphor trees are steamed in pot and evaporate, steamer be copper or
Stainless steel sets wooden steaming kier on steaming stove, and consistent with pot caliber size is sleeved on pot, when processing, trunk, tree root and tree
Branch is split into thin slice, is packed into steaming kier together with leaf, and the water in steamer is separated by 10 centimetres with raw material and starts to distill, when distillation cooling divide
From the steam with camphor and camphor oil, enter polycyclic dish type cooler by gas-guide tube, camphor and camphorated oil float on after condensation
The water surface is put camphorated oil in people's boiler, and second distillation is carried out, and collects 155-200 DEG C of distillate, the as camphor tree in raw material
Brain.
Further, it is easily cyclized into the property of isopulegol using citronellal, uses silica gel to be such as cyclized dextrorotation citronellal
At left-handed isopulegol, left-handed isopulegol is separated, hydrogenation generates the menthol in raw material.
Further, 0.1% aqueous sulfuric acid is heated to 60 DEG C, in 1,2- epoxy butanes are added dropwise in 1h, at 60-70 DEG C
Insulation reaction 0.5h is neutralized to pH7-7.5 with 40% liquid caustic soda, after decompression boils off water, then through rectifying, collects 110 DEG C, 3.72kPa points
It evaporates and obtains the butanediol in raw material.
Further, it is reacted with chlorethanol mixed chemical by sodium phenate and the Phenoxyethanol in raw material is made.
Further, glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, rear curtain are contained in the licorice root extract
Than wingceltis element, formoononetin and Quercetin.
Further, the spring, two season of autumn excavation legume kuh-seng dry root, remove root head and small supporting root, clean, do
It is dry, or fresh slices are taken advantage of, it is dry, it is extracted with water, the kuh-seng root extract extract in raw material is made.
Beneficial effects of the present invention：The present invention a kind of external preparation with mosquito-expelling and antipruritic, have both mosquito repellent, sterilization, anti-miliaria,
It is antipruritic and other effects, it can directly use, be applied to skin surface, can also be further used for preparing cosmetics, such as be prepared into
Floral water or bath foam etc. can also be used as after shave lotion use.
Specific implementation mode
To make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, with reference to
Specific implementation mode, the present invention is further explained.
The present invention provides a kind of technical solution：A kind of external preparation with mosquito-expelling and antipruritic, is made of following raw material：Water, second
Alcohol, methyl propanediol, camphor, menthol, butanediol, ammonium acryloyl taurate/VP copolymer, Phenoxyethanol, sub- perfume
Thatch oil, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, Artemisinin, glycosphingolipids.
Trunk, tree root, branch and the leaf for choosing 50 years or more camphor trees are steamed in pot and evaporate, and steamer is copper or stainless steel,
Wooden steaming kier is set on steaming stove, consistent with pot caliber size is sleeved on pot, when processing, trunk, tree root and branch is split into thin
Piece is packed into together with leaf in steaming kier, and the water in steamer is separated by 10 centimetres with raw material and starts to distill, and refrigerated separation is with camphor tree when distillation
The steam of brain and camphor oil enters polycyclic dish type cooler by gas-guide tube, and camphor and camphorated oil are kept afloat after condensation, camphor tree
Cerebrol is put in people's boiler, and second distillation is carried out, and collects 155-200 DEG C of distillate, the as camphor in raw material.
It is easily cyclized into the property of isopulegol using citronellal, dextrorotation citronellal is cyclized into left-handed different Hu with such as silica gel
Menthol, separates left-handed isopulegol, and hydrogenation generates the menthol in raw material.
0.1% aqueous sulfuric acid is heated to 60 DEG C, in 1,2- epoxy butanes are added dropwise in 1h, in 60-70 DEG C of insulation reaction
0.5h is neutralized to pH7-7.5 with 40% liquid caustic soda, and after decompression boils off water, then through rectifying, 110 DEG C of collection, 3.72kPa are fractionated and obtain former
Butanediol in material.
It is reacted with chlorethanol mixed chemical by sodium phenate and the Phenoxyethanol in raw material is made.
Containing glycyrrhizin, glycyrrhizic acid in the licorice root extract, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, thorn
Onocerin and Quercetin.
Spring, two season of autumn excavate the dry root of legume kuh-seng, remove root head and small supporting root, cleaning, drying, or take advantage of fresh-cut
Piece, it is dry, it is extracted with water, the kuh-seng root extract extract in raw material is made.
As an embodiment of the present invention：A kind of external preparation with mosquito-expelling and antipruritic of the present invention, has both mosquito repellent, kills
Bacterium, anti-miliaria, antipruritic and other effects, can directly use, be applied to skin surface, can also be further used for preparing cosmetics, example
It is such as prepared into floral water or bath foam, can also be used as after shave lotion use.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from the present invention spirit or
In the case of essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that come within the meaning and range of equivalency of the claims in the present invention
It is interior.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (7)
1. a kind of external preparation with mosquito-expelling and antipruritic, it is characterised in that：It is made of following raw material：Water, ethyl alcohol, methyl propanediol,
Camphor, menthol, butanediol, ammonium acryloyl taurate/VP copolymer, Phenoxyethanol, citronella grass oil, licorice extraction
Object, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, Artemisinin, glycosphingolipids.
2. a kind of external preparation with mosquito-expelling and antipruritic according to claim 1, it is characterised in that：Choose 50 years or more camphor trees
Trunk, tree root, branch and leaf be steamed in pot and evaporate, steamer is copper or stainless steel, wooden steaming kier is set on steaming stove, with pot bore
In the same size is sleeved on pot, and when processing, trunk, tree root and branch are split into thin slice, is packed into steaming kier together with leaf, steamer
Interior water is separated by 10 centimetres with raw material and starts to distill, and refrigerated separation carries the steam of camphor and camphor oil when distillation, by gas-guide tube
Into polycyclic dish type cooler, camphor and camphorated oil are kept afloat after condensation, and camphorated oil is put in people's boiler, are carried out secondary
155-200 DEG C of distillate, the as camphor in raw material are collected in distillation.
3. a kind of external preparation with mosquito-expelling and antipruritic according to claim 1, it is characterised in that：It is easily cyclized using citronellal
At the property of isopulegol, dextrorotation citronellal is cyclized into left-handed isopulegol with such as silica gel, separates left-handed different pennyroyal mint
Alcohol, hydrogenation generate the menthol in raw material.
4. a kind of external preparation with mosquito-expelling and antipruritic according to claim 1, it is characterised in that：By 0.1% aqueous sulfuric acid
60 DEG C are heated to, in 1,2- epoxy butanes are added dropwise in 1h, in 60-70 DEG C of insulation reaction 0.5h, pH7- is neutralized to 40% liquid caustic soda
7.5, after decompression boils off water, then through rectifying, 110 DEG C of collection, 3.72kPa are fractionated and obtain the butanediol in raw material.
5. a kind of external preparation with mosquito-expelling and antipruritic according to claim 1, it is characterised in that：By sodium phenate and chlorethanol
Mixed chemical reacts and the Phenoxyethanol in raw material is made.
6. a kind of external preparation with mosquito-expelling and antipruritic according to claim 1, it is characterised in that：The licorice root extract
In containing glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, formoononetin and Quercetin.
7. a kind of external preparation with mosquito-expelling and antipruritic according to claim 1, it is characterised in that：Spring, two season of autumn excavate beans
The dry root of section's plant kuh-seng removes root head and small supporting root, cleaning, drying, or takes advantage of fresh slices, dry, is extracted with water, and original is made
Kuh-seng root extract extract in material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810334673.9A CN108272696A (en) | 2018-04-15 | 2018-04-15 | A kind of external preparation with mosquito-expelling and antipruritic |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810334673.9A CN108272696A (en) | 2018-04-15 | 2018-04-15 | A kind of external preparation with mosquito-expelling and antipruritic |
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| CN108272696A true CN108272696A (en) | 2018-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810334673.9A Pending CN108272696A (en) | 2018-04-15 | 2018-04-15 | A kind of external preparation with mosquito-expelling and antipruritic |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685827A (en) * | 2018-08-28 | 2018-10-23 | 广州市华晟健康产业有限公司 | A kind of liquid liniment |
| CN112675085A (en) * | 2020-12-31 | 2021-04-20 | 广东伊茗药业有限公司 | Itching-relieving and soothing liquid for skin and preparation method thereof |
| CN112807259A (en) * | 2020-12-31 | 2021-05-18 | 乐比(广州)健康产业有限公司 | Safe and nontoxic mosquito repelling composition and preparation method and application thereof |
| CN114681353A (en) * | 2020-12-31 | 2022-07-01 | 广东伊茗药业有限公司 | Skin itching-relieving and soothing liquid suitable for infants and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108685827A (en) * | 2018-08-28 | 2018-10-23 | 广州市华晟健康产业有限公司 | A kind of liquid liniment |
| CN112675085A (en) * | 2020-12-31 | 2021-04-20 | 广东伊茗药业有限公司 | Itching-relieving and soothing liquid for skin and preparation method thereof |
| CN112807259A (en) * | 2020-12-31 | 2021-05-18 | 乐比(广州)健康产业有限公司 | Safe and nontoxic mosquito repelling composition and preparation method and application thereof |
| CN114681353A (en) * | 2020-12-31 | 2022-07-01 | 广东伊茗药业有限公司 | Skin itching-relieving and soothing liquid suitable for infants and preparation method thereof |
| CN112807259B (en) * | 2020-12-31 | 2023-05-19 | 乐比(广州)健康产业有限公司 | Safe and nontoxic mosquito-repellent composition and preparation method and application thereof |
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Application publication date: 20180713 |