CN114588215A - Itching-relieving spray for mosquito bites - Google Patents

Itching-relieving spray for mosquito bites Download PDF

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CN114588215A
CN114588215A CN202210270162.1A CN202210270162A CN114588215A CN 114588215 A CN114588215 A CN 114588215A CN 202210270162 A CN202210270162 A CN 202210270162A CN 114588215 A CN114588215 A CN 114588215A
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parts
itching
spray
relieving
mosquito
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刘延洲
黎艳秋
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Abstract

The invention discloses a mosquito bite itching relieving spray which is prepared from the following raw materials in parts by weight: 5-15 parts of rheum officinale, 5-15 parts of wild chrysanthemum, 5-15 parts of groundsel, 10-20 parts of common andrographis herb, 10-20 parts of hypericum japonicum, 10-20 parts of heartleaf houttuynia herb, 10-15 parts of great burdock achene, 10-15 parts of indigowoad leaf, 3-5 parts of pubescent holly root, 3-5 parts of solidago virgaurea and 3-5 parts of folium artemisiae argyi; mixing the above materials at a certain proportion, grinding into powder, stirring with appropriate amount of rice vinegar, processing, fermenting for more than 15 days, soaking in 60% ethanol for 7-15 days, mixing the powder and ethanol at a weight ratio of 20-30:65-80, and stirring for 2-10 times during fermentation; the invention has the effects of quickly relieving itching and swelling for red, swollen, painful and itchy skin caused by mosquito bites and eczema; has the functions of clearing away heat and toxic material, cooling blood, relieving itching and inhibiting bacteria.

Description

Itching-relieving spray for mosquito bites
Technical Field
The invention relates to the field of medicines, in particular to an antipruritic spray for mosquito bites.
Background
Mosquitoes stab the skin through the mouth organ of the mosquitoes, saliva or venom injected into the skin generates allergic reaction after entering the skin of a human body to cause inflammation, and symptoms such as rash, pruritus and the like are generated; some pathogenic pathogens can enter human body through skin by mosquito bite to cause infectious diseases; most of mosquito sprays in the current market adopt chemical raw material preparations, have certain toxic and side effects on human bodies, and particularly for children, how to provide a pure traditional Chinese medicine preparation and a spray capable of quickly relieving itching and diminishing swelling is a problem to be solved urgently.
In the prior art, the technical scheme of the mosquito bite spray agent comprises the following steps:
chinese patent application 201811474441.X discloses a mosquito repellent spray and a method of preventing stings and/or repelling harmful insects from human and/or animal subjects, the method comprising spraying a liquid formulation containing a vapour active pyrethroid and a volatile organic solvent at the site of a substrate, the formulation being provided in a push-on spray bottle, and the vapour active pyrethroid being present in the formulation in an amount of 1 to 12% by weight, and/or the formulation being provided at a pyrethroid deposition of 1 to 12mg per spray.
Chinese patent application 201610452778.5 discloses a mosquito repellent spray for skin surface, which adopts essential oil with better compatibility with skin as main component, and simultaneously adds mosquito repellent component with functional effect and active component capable of improving the activity of the mosquito repellent component, so that the prepared spray can be better adsorbed on the skin surface and has mosquito repellent effect.
However, the chemical raw material preparation is added as the main component in the prior art, so that certain side effects exist on the human body, and the adverse effects are caused to pregnant women and children.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the mosquito bite stabilizing and itching relieving spray, which adopts a pure traditional Chinese medicine formula aiming at the defects in the prior art, has no toxic or side effect, and has the effects of quickly relieving itching and swelling and eliminating skin inflammation and pain caused by mosquito bite and insect bite and eczema; has the functions of clearing away heat and toxic material, cooling blood, relieving itching and inhibiting bacteria.
The invention provides the following technical scheme:
a mosquito bite itching relieving spray is prepared from the following raw materials in parts by weight: 5-15 parts of rheum officinale, 5-15 parts of wild chrysanthemum flower, 5-15 parts of groundsel, 10-20 parts of common andrographis herb, 10-20 parts of hypericum japonicum, 10-15 parts of folium isatidis and 3-5 parts of pubescent holly root.
Preferably, the raw material components also comprise 3-5 parts of solidago decurrens and 3-5 parts of folium artemisiae argyi.
Preferably, the raw material components also comprise 10-15 parts of burdock.
Preferably, the raw material components also comprise 10-20 parts of houttuynia cordata.
Preferably, the components of each raw material component are in powder form, and the particle size of the medicinal powder is 30-100 meshes.
Preferably, the particle size of the medicinal powder is 40-60 meshes.
The main effects of the rhubarb, the wild chrysanthemum flower, the groundsel herb, the common andrographis herb, the hypericum japonicum, the heartleaf houttuynia herb, the great burdock achene and the folium isatidis in the formula are clearing heat and purging fire, cooling blood and removing toxicity, and the functions of clearing heat and removing toxicity, cooling blood and relieving itching and inhibiting bacteria can be improved among the rhubarb, the hypericum japonicum and the groundsel herb, especially the synergistic effect is realized; the herba solidaginis and the pubescent holly root have the main effects of dispelling wind, clearing heat and relieving cough; the folium artemisiae argyi has the main effects of warming channels to stop bleeding, dispelling cold and relieving pain; however, the common action of the solidago virgaurea, the pubescent holly root and the folium artemisiae argyi has good effects of clearing away heat and toxic materials, relieving itching and easing pain, and particularly, the solidago virgaurea and the pubescent holly root have a synergistic effect.
The groundsel in the formula belongs to cold property, neutralizes the cold property of the groundsel through the combined action of the groundsel, the burdock and the houttuynia cordata, can be suitable for people with cold body, and achieves the good purposes of clearing heat and removing toxicity.
In order to better realize the effects of relieving itching and reducing swelling, the invention also provides a preparation method of the itching-relieving spray for treating mosquito bite, which comprises the following steps:
s1, after being prepared according to the formula proportion, the raw materials are ground into powder together;
s2, adding a proper amount of rice vinegar and ice blocks and stirring;
s3, filling the mixture into a cylinder, sealing, processing and fermenting;
s4, adding ethanol for soaking;
and S5, independently bottling.
Preferably, the jar-filling and sealing are carried out for 20-40 days of fermentation at normal temperature.
Preferably, the fermentation days of the jar-filling and sealing at constant temperature can be shortened to 10-20 days.
Preferably, white flora is generated on the surface of the fermented medicinal powder and the medicinal fragrance is given off, which indicates that the fermentation is finished.
Preferably, soaking in 60% ethanol for 7-15 days, wherein the weight ratio of the medicinal powder to the ethanol is 20-30:65-80, and stirring for 2-10 times during fermentation.
Preferably, after soaking in ethanol, the supernatant is decanted, filtered and dispensed, e.g., into squeeze spray vials.
Preferably, after decanting the supernatant, the residue is further soaked in 70% ethanol for 7-15 days, decanted, filtered and dispensed into, for example, squeeze spray vials.
In addition, the fineness of the medicinal powder particles is one of the reasons for influencing the medicinal effect; in experiments, when the particle size of the medicinal powder is less than 30 meshes, the medicinal powder has larger particles, poorer ductility, poor fermentation effect and poor efficacy effect; the particle size of the medicinal powder is higher than 100 meshes, and the medicinal powder is difficult to filter because the particle size is too small and the supernatant is difficult to pour out.
The invention further compares the experiment and finds that the fineness of the medicine powder also influences the fermentation time, when the fineness of the medicine powder is 30-100 meshes, the fermentation completion time (in Henan province) of the medicine powder is about 30 days; when the fineness of the medicinal powder is 40-60 meshes, the fermentation time of the medicinal powder is about 18 days; therefore, the test result shows that the fermentation time is shortest when the grain diameter of the medicinal powder is 40-60 meshes, and the fermentation time is short, the number of active floras is large, the time is saved, and the cost is saved.
The using method comprises the following steps: spraying the bottled spray to the affected part 3-8 times daily, 5-10 times per time.
When the itching relieving spray for mosquito bite is used, the spraying times n are 3-8 times, and the continuous use period T is 10-15 days as a treatment course; in order to further improve the drug effect, the d.n is more than or equal to 90 and less than or equal to 800 between the spraying times n and the particle size d of the medicinal powder; the spraying times n of the itching relieving spray, the particle size d of the medicinal powder and the continuous use period T satisfy the following relations:
T=（d/n）*α；
wherein alpha is a relation factor and has a value range of 0.25-3.33.
The following is the observation of the treatment effect of the mosquito bite itching relieving spray of the invention on insect bite dermatitis.
1. Clinical data
Selecting 50 patients with skin red swelling and pruritus caused by insect bite dermatitis, and randomly dividing the patients into two groups, namely a treatment group and a control group; treatment group 25, age 23-60 years; the control group is 25 cases, and the age is 20-65 years.
2. Method of treatment
2.1 the itching relieving spray for mosquito bites of the invention is used by a treatment group, and the formula is as follows: 150g of rhubarb, 150g of wild chrysanthemum flower, 150g of groundsel, 200g of common andrographis herb, 200g of hypericum japonicum, 200g of heartleaf houttuynia herb, 150g of great burdock achene, 150g of dyers woad leaf, 50g of pubescent holly root, 50g of solidago and 50g of Chinese mugwort leaf.
2.2 configuration method: grinding 150g of rheum officinale, 150g of wild chrysanthemum, 150g of groundsel, 200g of andrographis paniculata, 200g of hypericum japonicum, 200g of houttuynia cordata, 150g of burdock, 150g of folium isatidis, 50g of pubescent holly root, 50g of solidago decurrens and 50g of folium artemisiae argyi into 50-mesh particles, adding rice vinegar, stirring, filling into a jar, sealing, processing and fermenting for 15 days; after completion of fermentation, 4500ml of 60% ethanol was added and soaked for 10 days, 2000ml of supernatant was decanted, filtered, and filled into a vial with a nozzle for use.
2.3 methods of use: spraying onto the affected part for 3-8 times a day, with 10 days as a treatment course; the treatment effect was evaluated after the administration.
2.4 adverse reactions: has no adverse reaction.
2.5 in the control group, mometasone furoate cream is externally applied to patients for 3-5 times every day, all other medicines are stopped during the application period, and the curative effect is evaluated after 10 days of application.
3 analysis of therapeutic Effect
3.1 the curative effect standard is cured: the disease completely disappears and does not relapse; improvement: the red swelling and pruritus symptoms are obviously relieved; and (4) invalidation: the red, swollen and itching symptoms are not improved or are not improved obviously.
3.2 therapeutic results
Two groups of therapeutic effect comparison table
Group of Number of cases Cure of disease Improvement of life Invalidation Effective rate (%)
Treatment group 25 20 5 0 100
Control group 25 18 4 3 88
As can be seen from the table above, compared with the medicaments in the market, the mosquito bite itching relieving spray has more obvious treatment effect, and no toxic or side effect is caused because of the Chinese medicinal preparation.
Compared with the prior art, the invention has the following beneficial effects:
(1) the itching relieving spray for mosquito bites is accurate in formula, various medicines are matched with one another to play a role together, and the effect is rapid and obvious.
(2) The spray for relieving itching caused by mosquito bite is prepared by grinding, fermenting and processing medicines, and has the advantages of full release of medicine molecules, enough medicinal gas and better treatment effect.
(3) The itching relieving spray for mosquito bites is independently packaged into a bottle, is safe and environment-friendly, and is convenient and quick to use.
(4) The invention relates to a mosquito bite itching relieving spray, which mainly takes pure traditional Chinese medicines as a formula, has no toxic or side effect, and has the effects of quickly relieving itching and swelling for red, swollen, painful and itchy skin caused by mosquito bites and eczema; has effects of clearing away heat and toxic materials, cooling blood, relieving itching, and inhibiting bacteria.
(5) The main effects of the rhubarb, the wild chrysanthemum flower, the climbing groundsel herb, the common andrographis herb, the hypericum japonicum, the heartleaf houttuynia herb, the great burdock fruit and the folium isatidis are heat clearing and fire purging, blood cooling and detoxifying, the functions of clearing heat and detoxifying, cooling blood and relieving itching and inhibiting bacteria can be improved among the rhubarb, the hypericum japonicum and the climbing groundsel herb, and especially the rhubarb, the hypericum japonicum and the climbing groundsel herb have a synergistic effect.
(6) The mosquito bite itching relieving spray has the main effects of dispelling wind, clearing heat and relieving cough; the folium artemisiae argyi has the main effects of warming channels to stop bleeding, dispelling cold and relieving pain; however, the common action of the solidago virgaurea, the pubescent holly root and the folium artemisiae argyi has good effects of clearing away heat and toxic materials, relieving itching and easing pain, and particularly, the solidago virgaurea and the pubescent holly root have a synergistic effect.
(7) The invention relates to a mosquito bite itching relieving spray, which is prepared from groundsel, belongs to cold, neutralizes the cold property of groundsel through the combined action of groundsel, burdock and houttuynia cordata, is suitable for cold people, and achieves the good purposes of clearing heat and removing toxicity.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a graph of the content of a portion of the formulation of the present invention.
Fig. 2 is a flow chart of the spray preparation process of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described in detail and completely with reference to the accompanying drawings. It is to be understood that the described embodiments are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example one
As shown in figure 1-2, weighing 10 parts of rhubarb, 10 parts of wild chrysanthemum flower, 10 parts of groundsel, 15 parts of common andrographis herb, 15 parts of hypericum japonicum, 15 parts of heartleaf houttuynia herb, 10 parts of great burdock achene, 10 parts of indigowoad leaf, 3 parts of pubescent holly root, 3 parts of solidago decurrens and 3 parts of Chinese mugwort leaf.
After being mixed according to the formula proportion, the raw materials are ground into powder together; the particle size of the medicinal powder is 50 meshes. Adding appropriate amount of rice vinegar and ice, and stirring; placing in a jar, sealing, fermenting for 15 days to generate white flora on the surface and emit medicinal fragrance, indicating that fermentation is completed, and stirring for 5 times in the fermentation process; after completion of fermentation, 4500ml of 60% ethanol was added and soaked for 10 days, 2000ml of supernatant was decanted, filtered, and filled into a vial with a nozzle for use.
When the itching relieving spray for mosquito bites is used, the spraying frequency is 3-8 times, and the continuous use period is 10-15 days.
Example two
Weighing 5 parts of rheum officinale, 5 parts of wild chrysanthemum, 5 parts of groundsel, 5 parts of common andrographis herb, 8 parts of hypericum japonicum, 8 parts of houttuynia cordata, 5 parts of great burdock achene, 5 parts of folium isatidis, 1 part of pubescent holly root, 1 part of solidago decurrens and 1 part of folium artemisiae argyi.
After being mixed according to the formula proportion, the components are ground into powder together; the particle size of the medicinal powder is 50 meshes. Adding appropriate amount of rice vinegar and ice, and stirring; placing in a jar, sealing, fermenting for 15 days to generate white flora on the surface and emit medicinal fragrance, and stirring for 5 times during fermentation process; after completion of fermentation, 2000ml of 60% ethanol was added and soaked for 10 days, 800ml of supernatant was decanted, filtered, and filled into a vial with a nozzle for use.
When the itching relieving spray for mosquito bites is used, the spraying frequency is 3-8 times, and the continuous use period is 10-15 days.
EXAMPLE III
Weighing 15 parts of rhubarb, 15 parts of wild chrysanthemum flower, 15 parts of groundsel, 20 parts of common andrographis herb, 20 parts of hypericum japonicum, 20 parts of heartleaf houttuynia herb, 15 parts of great burdock achene, 15 parts of dyers woad leaf, 5 parts of pubescent holly root, 5 parts of solidago and 5 parts of folium artemisiae argyi.
After being mixed according to the formula proportion, the raw materials are ground into powder together; the particle size of the medicinal powder is 50 meshes. Adding appropriate amount of rice vinegar and ice, and stirring; placing in a jar, sealing, fermenting for 15 days to generate white flora on the surface and emit medicinal fragrance, and stirring for 5 times during fermentation process; after fermentation, 6000ml of 60% ethanol is added for soaking for 10 days, 3000ml of supernatant is poured out, filtered and put into a small bottle with a nozzle for standby.
When the itching relieving spray for mosquito bites is used, the spraying frequency is 3-8 times, and the continuous use period is 10-15 days.
The itching relieving spray for stabilizing mosquito bites is obtained by the design, aims at the defects in the prior art, adopts a pure traditional Chinese medicine formula, has no toxic or side effect, and has the effects of quickly relieving itching and swelling for red, swollen, painful and itchy skin caused by mosquito bites and insect bites and eczema; has the functions of clearing away heat and toxic material, cooling blood, relieving itching and inhibiting bacteria.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (6)

1. The mosquito bite itching relieving spray is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of rheum officinale, 5-15 parts of wild chrysanthemum flower, 5-15 parts of groundsel, 10-20 parts of common andrographis herb, 10-20 parts of hypericum japonicum, 10-15 parts of folium isatidis and 3-5 parts of pubescent holly root.
2. The anti-itching spray for mosquito bites according to claim 1, wherein the raw material components further comprise 3-5 parts of goldenrod herb and 3-5 parts of folium artemisiae argyi.
3. The spray for relieving itching of mosquito bite according to claim 1 or 2, characterized in that the raw material component further comprises 10-15 parts of burdock.
4. The spray for relieving itching of mosquito bite according to any one of claims 1 to 3, wherein the raw material component further comprises 10 to 20 parts of houttuynia cordata.
5. The spray for relieving itching of mosquito bite according to any one of claims 1 to 4, wherein the components of each raw material component are in powder form, and the particle size of the medicinal powder is 30 to 100 meshes.
6. The spray for relieving itching of mosquito bite according to claim 2 or 3, wherein the particle size of the powder is 40-60 mesh.
CN202210270162.1A 2022-03-18 2022-03-18 Itching-relieving spray for mosquito bites Pending CN114588215A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1165012A (en) * 1997-01-21 1997-11-19 石小雷 Instant stop itching spray agent for mosquito and insect bite and its preparation method
CN109432218A (en) * 2018-12-25 2019-03-08 湖北悟丰五艾有限公司 A kind of anti-inflammatory anti-itch mosquito repellent traditional Chinese medicinal ointment and preparation method thereof containing folium artemisiae argyi

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1165012A (en) * 1997-01-21 1997-11-19 石小雷 Instant stop itching spray agent for mosquito and insect bite and its preparation method
CN109432218A (en) * 2018-12-25 2019-03-08 湖北悟丰五艾有限公司 A kind of anti-inflammatory anti-itch mosquito repellent traditional Chinese medicinal ointment and preparation method thereof containing folium artemisiae argyi

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Application publication date: 20220607