CN103655718B - Traditional Chinese medicine composition, preparation, and floral water and application method thereof - Google Patents
Traditional Chinese medicine composition, preparation, and floral water and application method thereof Download PDFInfo
- Publication number
- CN103655718B CN103655718B CN201210315409.3A CN201210315409A CN103655718B CN 103655718 B CN103655718 B CN 103655718B CN 201210315409 A CN201210315409 A CN 201210315409A CN 103655718 B CN103655718 B CN 103655718B
- Authority
- CN
- China
- Prior art keywords
- extract
- weight portion
- floral water
- chinese medicine
- flos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the fields of the traditional Chinese medicines and the flavor fragrance cosmetics, and specifically relates to a pure natural plant flower traditional Chinese medicine composition for repelling mosquitoes and relieving itching, a preparation, and floral water and an application method thereof. The traditional Chinese medicine comprises salvia miltiorrhiza, mint, bezoar, saffron crocus, honeysuckle, mint, fresh sheep skin, radix sophorae flavescentis and so on. The traditional Chinese medicine preparation is mainly prepared by extracting the raw materials in a certain ratio. The floral water provided by the invention can be prepared from ethanol, deionized water and the extract of the traditional Chinese medicine composition according to the production process of the floral water. The formula of the traditional Chinese medicine preparation or the floral water is based on sterilizing and relieving itching, and comprises purely natural raw materials without any chemicals such as essence, pigment and preservative. In addition, the traditional Chinese medicine preparation and the floral water comprise two or more than two formulas; and due to the adoption of the application method provided by the invention, the mosquito repelling range is increased comprehensively so that the effects of repelling mosquitoes and relieving itching can be better, while the effects of quickly relieving itching caused by mosquitoes and itching caused by miliaria, and relieving summer heat and refreshing are achieved.
Description
Technical field
The present invention relates to Chinese medicine and fragrance flavor and cosmetic field, be specifically related to a kind of pure natural plant flowers Chinese medicine composition for mosquito-expelling and antipruritic, preparation, floral water and using method thereof.
Background technology
According to statistics, nearly more than the 3000 kinds of mosquitoes in the whole world.China has more than 300 to plant, widely distributed.Common mosquito has Anopheles sinensis Anopheleshyrcanus sinensis, culex pipiens pallens Culex pipiens pallens, Aedes albopictus Aedesalbopictus tri-class.In Africa, Asia and America, cause because of mosquito bite being infected with malaria dead number per year over 1000000 people.The biting and have a strong impact on sleep of mosquito in summer, for majority, mosquito bite causes pruritus to create disturbances to, and needs application Chinese medicine antipruritic liquid or floral water etc. to nurse.The skin problem such as mosquito bite and miliaria usually occurs together, has not only had a strong impact on daily life, and has likely caused serious anaphylaxis and general toxicity, merited attention.
Mosquito bite dermatitis (Mosquito-bite dermatitis, MBD) is the allergic skin inflammation caused by mosquito bite, is the main Types of insect dermatitis.In summer and autumn, mosquito is very active, and the erythema that welt is the same is often appearred in people after mosquito bite, has vesicle, be snapped region and mainly concentrate on lower limb, lower back in the middle of erythema.If pruritus is serious, scratching can make original dermatitis increase the weight of, and wound is scratched larger and larger, finally causes prurigo, eczema etc., and causes secondary skin infection and skin ulcer, can because of pigmentation scar after recovery from illness.
Research shows, the Secondary cases welt that mosquito bite causes and Delayed onset pimple, is skin type I allergy and the reaction of IV pimple respectively.Early stage in morbidity, when people is by mosquito bite, saliva is injected skin by mosquito, xenogenesis sialoprotein/polypeptide that it contains, as adenosinetriphosphataes and glycosidase, make people's sensitization, particular immunoglobulin molecule I gE and IgG can be detected in adult or serum of children, wherein IgE mainly causes welt and erythema, and IgG is relevant with dermoreaction degree: bite latter 30 to 40 minutes, skin allergy medium histamine and leukotriene are secreted and are increased, and jointly cause type i allergic reaction, and the symptoms such as red, swollen, hot, pain appear rapidly in skin.After about 4 to 6 hours, can postpone to excite IV pimple to react, and continue several days time.No matter being fall ill early stage or period of delay, all there is violent pruritus in skin affected part.Therefore, effective nursing skin mosquito bite, need to adopt the Chinese medicine antipruritic liquid, floral water product etc. with the effect such as antiinflammatory, antiallergic, dermoreaction could be controlled in time, recover skin health.
At dermal surgery field, China's Chinese medicine and pharmacy since ancient times and accumulate deep theoretic knowledge and abundant clinical experience.The insect dermatitis that mosquito bite causes, belongs to Chinese medicine " evil insect stings " category, another name insect bite wound, insect bite dermatitis, evil insect stings wound etc.After mosquito bite, all initial stage affected parts are rubescent has an itch, and has welt, and there is vesicle on top, or insect bite vestige, and continue then pruritus and pain occurring alternately, and scarlet slow swollen, body of the tongue is white, and tongue is white, and slippery and rapid pulse, its disease belongs to damp and hot poison and attacks card.Chinese medicine is thought, to the dermatologic disorders that mosquito bite causes, need control, adopt heat-clearing and toxic substances removing from cardiopulmonary opinion, the treatment by Chinese herbs of dehumidifying removing heat from blood, adopt multiple pure natural plant extract collocation medication, can obtain good effect.In prior art, for the raw material of Chinese medicine of heat clearing away mosquito-expelling and antipruritic, what relate generally to is Radix Salviae Miltiorrhizae, Flos Chrysanthemi Indici, Flos Lonicerae and Flos Caryophylli etc.The present invention has larger improvement in prescription element.
Chinese medicine mosquito-expelling and antipruritic preparation, in prior art, according to the mechanism of anophelifuge, based on Chinese medical science theory, from Chinese herbal medicine, select the raw materials such as Radix Salviae Miltiorrhizae, Flos Caryophylli, Flos Lonicerae, Flos Chrysanthemi Indici, carry out prescription extraction, be aided with the Chinese medicine preparation processed accordingly and be prepared from.But it is single all to there is antipruritic effect in existing Chinese medicine mosquito-expelling and antipruritic preparation, is only limitted to the mosquito of Partial Species, cannot all sidedly to the problem that multiple mosquito bite all has effect.
Floral water (Florida Water) refers to by the formulated liquid of the compositions such as ethanol, water, essence or additive, the product that have fragrance to human body skin, refrigerant, miliaria of dispelling is antipruritic etc. acts on.Dispelling after (with reference to national standard " floral water " QB/T1858.1-2006) can be used for summer and autumn shower, miliaria is refreshed oneself, mosquito control is bitten.Although national floral water kind brand is a lot, its traditional raw material is all mainly Mentholum, Borneolum Syntheticum, thymol, Camphora, essence, ethanol and deionized water, and except having refrigerant, fragrant and dispelling except miliaria function, antipruritic effect is uneven.China's existing market sell goods, respectively have feature, but due to lack system to the research of mosquito type and the guidance of Chinese medical theory, can not tackle various mosquito bite, antipruritic effect is unsatisfactory comprehensively.Further, common product includes the anophelifuge chemical component such as diethyltoluamide (DEET), and have potential hazardness, side effect is obvious.Generally, the existing floral water product of China, in mosquito bite home care, need to weed out the old and bring forth the new, improve performance, to better meet consumer demand, and development market.
In the using method of Chinese medicine anti-pruritic formulation and floral water, existing method is mainly simply smeared, single, repeatedly or timing smearing repeatedly, if use aerosol apparatus, is then corresponding spraying.The present invention has corresponding improvement in occupation mode.
In prior art, according to the mechanism of mosquito-expelling and antipruritic, based on Chinese medical science theory, take skin health as aim, according to monarch, minister, the traditional Chinese medical science prescription thought of helping, making, in the prior art, the Chinese medicine medicines such as the Radix Salviae Miltiorrhizae selected from natural Chinese medicinal herb plant, Flos Caryophylli, Flos Lonicerae, Flos Chrysanthemi Indici, the Radix Astragali, Herba Menthae, extract respectively, the functional component obtained, releive skin and abnormal smells from the patient anophelifuge aspect antipyretic from suppression sweat secretion, bacteriostasis and sterilization, antiinflammatory can reach certain mosquito-expelling and antipruritic effect.
Above-mentioned Chinese medicine composition, the limited efficiency of anophelifuge, can not reach the effect of comprehensively driving away various mosquito.In the present invention, according to practical experience and experiment, add Radix Sophorae Flavescentis, Cortex Dictamni by the mode of grouping collocation, Flos Campsis, Herba Portulacae, Herba Violae, Stigma Croci six kind of plant flowers, with the use of, the effect in mosquito-expelling and antipruritic is more comprehensive, can cover the great majority of the mosquito specie that China finds.
The present invention selects Radix Salviae Miltiorrhizae, Flos Caryophylli, Flos Lonicerae, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, Herba Menthae, Cortex Dictamni, Flos Campsis, Herba Portulacae, Herba Violae, the Chinese medicine medicines plant societys such as Stigma Croci, every medicine synergism.
Effect brief introduction of each herbal medicine is as follows:
1, Radix Salviae Miltiorrhizae: nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood is subsided a swelling, and clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
2, Flos Caryophylli: nature and flavor are pungent, temperature, returns lunar, sufficient positive bright, the shaoyin channel of hands.Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's pain, hernia, ringworm.
3, Flos Lonicerae: sweet in the mouth; Cold.Return lung; Stomach warp.Effect: heat-clearing and toxic substances removing.Epidemic febrile disease is generated heat; Temperature dysentery.Cure mainly: furuncle; Carbuncle; Erysipelas; Sore throat and multi-infection disease.
4, Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent.Effect, heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Cure mainly: furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension.
5, the Radix Astragali: sweet in the mouth, feeble QI temperature, gas is thin and taste is dense, can rise and can fall, and the yang aspect of yang is also, nontoxic.Special QI invigorating.To start with warp that is lunar, the few the moon of lunar, the hands of foot.Its function is a lot of, and its only effect person, especially enriching blood.
6, Herba Menthae: be one of Chinese conventional Chinese medicine.Pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.
7, Cortex Dictamni: gas is trembled with fear benefaction, and bitter in the mouth is dry, enters lung meridian, therefore can remove wind, enters small intestine meridian, therefore can dry, and husband's rheumatism was both removed, then vim and vigour from living, also go by heat.Control all mange, aversion to wind, scabies, Fructus Myricae rubrae, all skin ulcer pyretic toxicity.
8, Flos Campsis: the function with promoting the circulation of blood blood stasis removing, cooling blood, expelling wind, acrid in the mouth acid, cold nature returns liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus, the disease such as acne.
9, Herba Portulacae: cold in nature, sweet in the mouth acid.Enter heart channel, Liver Channel, spleen channel, large intestine channel.Function: heat-clearing and toxic substances removing, cooling blood for hemostasis.Cure mainly: pyretic toxicity dysentery, pyretic stranguria, urine retention, leucorrhea with red and white discharge, metrorrhagia, hemorrhoidal bleeding, skin infection carbuncle furuncle, erysipelas, scrofula, exudative dermatitis, in vain bald, dysentery, toxic-heat and blood stasis, carbuncle furuncle, eczema, snake bite and insect sting, have blood in stool, metrostaxis, modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, anusitis, bleeding hemorrhoids etc. mostly.
10, Herba Violae: bitter, acrid, cold is nontoxic; GUIXIN, Liver Channel.Function cures mainly: its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.
11, Stigma Croci: sweet in the mouth is put down, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, traumatic injury etc.
12, Radix Sophorae Flavescentis: bitter in the mouth; Cold in nature.Return Liver Channel, kidney channel.Cure mainly: heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.
In formula of the present invention, the major function of each taste medicine is allocated as follows:
Radix Salviae Miltiorrhizae, Herba Menthae, Flos Lonicerae, Flos Chrysanthemi Indici have and improve that blood circulation, anti-inflammation detumescence are antipruritic, the effect of skin of releiving; Flos Caryophylli, Herba Portulacae, Herba Violae, Stigma Croci play bacteriostasis and sterilization, anti-inflammatory and antalgic is antipruritic, abnormal smells from the patient goes anophelifuge worm effect; Effect that Cortex Dictamni, Radix Sophorae Flavescentis, Flos Campsis play anti-inflammation, heat clearing away, abnormal smells from the patient walk quickly and keep away mosquito; The Radix Astragali plays the effect suppressing skin sweat secretion, invigorating QI to consolidate the body surface resistance.
In formula of the present invention, formula based on Radix Salviae Miltiorrhizae, Herba Menthae, Flos Lonicerae, Flos Chrysanthemi Indici, the Radix Astragali and Flos Caryophylli is one group, plays and improves blood circulation, anti-inflammation detumescence, suppression perspiration, skin of releiving, and general itching-relieving efficacies.Herba Portulacae, Cortex Dictamni and Flos Campsis are one group, can not play a role special mosquito for general itching-relieving efficacies, can play the effect of mosquito-expelling and antipruritic.Radix Sophorae Flavescentis, Stigma Croci and Herba Violae one group, can not play a role special mosquito for general itching-relieving efficacies equally, can play the effect of mosquito-expelling and antipruritic.
Through long-term practice and experiment, Herba Portulacae, Cortex Dictamni and Flos Campsis one group of formula and Radix Sophorae Flavescentis, Stigma Croci and Herba Violae one group of formula cannot confuse rear long-term preservation, therefore appeal two group of formula is arranged in pairs or groups with the basic components of Radix Salviae Miltiorrhizae, Herba Menthae, Flos Lonicerae, Flos Chrysanthemi Indici, the Radix Astragali and Flos Caryophylli by the present invention respectively mutually, two group of formula can be used alone.When two group of formula are used alone the effect that still cannot obtain desirable mosquito-expelling and antipruritic, two formula can be combined.
By applying the corresponding formulated Chinese medicine preparation of above-mentioned formula or floral water, in conjunction with corresponding using method, multi-flavor formula works in coordination with onset, cooperatively interact, releive skin and abnormal smells from the patient anophelifuge aspect antipyretic from suppression sweat secretion, bacteriostasis and sterilization, antiinflammatory can jointly reach desirable repelling effect.
Concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition with mosquito-expelling and antipruritic effect, it is characterized in that, said composition is made up of the crude drug of following weight: Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Astragali 10-20 weight portion, Flos Lonicerae 10-30 weight portion, Flos Chrysanthemi Indici 10-30 weight portion, Flos Caryophylli 10-20 weight portion, Herba Menthae 10-30 weight portion.
In addition, the crude drug that can also comprise following weight proportion in this Chinese medicine composition is made: Cortex Dictamni 10-20 weight portion, Flos Campsis 10-20 weight portion, Herba Portulacae 10-20 weight portion.
In addition, the crude drug also comprising following weight proportion in said composition is made: Radix Sophorae Flavescentis 15-30 weight portion, Stigma Croci 10-20 weight portion, Herba Violae 10-20 weight portion.
A kind of Chinese medicine preparation, is characterized in that, by above-mentioned Chinese medicine composition, it adds that on pharmaceutics, the extraction of acceptable adjuvant is prepared from.
A kind of floral water, it is characterized in that, main component contained by it is ethanol, Chinese medicinal plant extract, trehalose, pantothenylol, citric acid, sodium citrate and deionized water; Wherein, described Chinese medicinal plant extract is selected from two or more following materials: Radix Salviae Miltiorrhizae extract, Radix Sophorae Flavescentis extract, Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Folium Menthae extract, Flos Caryophylli extract, Cortex Dictamni extract, Flos Campsis extract, Herba portulacae extract, Herba Violae extract, Radix Astragali extract, Stigma Croci extract.
In addition, the Chinese medicinal plant extract of this floral water is selected from two or more following materials: Radix Salviae Miltiorrhizae extract, Radix Astragali extract, Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Folium Menthae extract, Cortex Dictamni extract, Flos Campsis extract, Herba portulacae extract.
In addition, the Chinese medicinal plant extract of this floral water is selected from two or more following materials: Radix Salviae Miltiorrhizae extract, Radix Astragali extract, Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Folium Menthae extract, Flos Caryophylli extract, Radix Sophorae Flavescentis extract, Stigma Croci extract, Herba Violae extract.
A floral water combination, is combined by above-mentioned two kinds of floral water.Also external spraying agent or aerosol can be made.
A kind of floral water using method, when the above-mentioned floral water combination of use, at mosquito bite place, first be used alone a kind of floral water in combinations thereof, if be not effective, then use another floral water at mosquito bite place, if be not still effective, then by two kinds of floral water at short notice, concrete example as used simultaneously within 10 seconds.
Use refers to first to be smeared affected part or sprays, then carries out soft.
Beneficial effect of the present invention:
Chinese medicine preparation provided by the invention and corresponding floral water, have without any chemical addition agent, have no side effect, use the formula of pure natural, the formula different with two groups by basic components is formulated respectively, and two group of formula act on respectively, with strong points, antipruritic effect is good, and anophelifuge kind is comprehensive.Adult, child and baby all can use.
Summary of the invention
The object of the invention is to propose a kind of can the Chinese medicine composition of mosquito-expelling and antipruritic and Chinese medicine preparation efficiently and safely.
Another object of the present invention is to propose a kind ofly to have efficiently, mosquito-expelling and antipruritic effect all sidedly, pure natural plant flowers floral water.
The third object of the present invention is to propose a kind of method using Chinese medicine preparation and floral water.
Invention thinking of the present invention is:
Detailed description of the invention
The present embodiment medical material used all can be bought from China Medicament Group Corp. and obtain, and meets Pharmacopoeia of People's Republic of China 2005 editions standards.
Embodiment 1
The preparation of Chinese medicine extract of the present invention
(1) each crude drug is taken according to following proportioning;
Radix Salviae Miltiorrhizae 20 grams, Flos Lonicerae 10 grams, Herba Menthae 10 grams, Flos Chrysanthemi Indici 10 grams, the Radix Astragali 10 grams and Flos Caryophylli 10 grams
(2) crude drug being added percent by volume is 60% EtOH Sonicate pretreatment, and the mass volume ratio (g/mL) of crude drug and ethanol is 1:30.Namely add 2100mL ethanol, ultrasonic pretreatment time is 30 minutes; This ultrasonic pretreated ultrasonic frequency is 50kHz, and power is 160W.
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted: be heated to 50 DEG C, and stirring and refluxing extracts 60min, reclaims extracting solution; Second time reflux, extract, the mass volume ratio (g/mL) of raw material and ethanol is 1:20, and temperature is 50 DEG C, and stirring and refluxing extracts 60min, stops heating, collects the extracting solution of twice;
(4) 45 DEG C are cooled to; Fine straining after thick worry, thick worry gauze used is 200 orders, and fine straining selects cake filtration (more than 800 orders), and gained filtrate is Chinese medicine extract of the present invention.
Measure pH value to filtrate after sucking filtration, solid content, measurement result is: pH value is 6.0-7.0, solid content 15-25%; 85 DEG C are incubated 30 minutes afterwards, and water-bath is cooled to room temperature, obtains product.Afterwards as required, can subsequent operation be carried out, as sterilization, fill etc.
Embodiment 2
The preparation two of Chinese medicine extract of the present invention
(1) each crude drug is taken according to following proportioning;
Radix Salviae Miltiorrhizae 10 grams, Flos Lonicerae 10 grams, Herba Menthae 5 grams, Flos Chrysanthemi Indici 5 grams, the Radix Astragali 5 grams and Flos Caryophylli 5 grams, Herba Portulacae 5 grams, Cortex Dictamni 5 grams and Flos Campsis 10 grams.
(2) crude drug being added percent by volume is 50% EtOH Sonicate pretreatment, and the mass volume ratio (g/mL) of crude drug and ethanol is 1:20.Namely add 1200mL ethanol, ultrasonic pretreatment time is 30 minutes; This ultrasonic pretreated ultrasonic frequency is 50kHz, and power is 160W.
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted: be heated to 50 DEG C, and stirring and refluxing extracts 60min, reclaims extracting solution; Second time reflux, extract, the mass volume ratio (g/mL) of raw material and ethanol is 1:30, and temperature is 50 DEG C, and stirring and refluxing extracts 60min, stops heating, collects the extracting solution of twice;
(4) 45 DEG C are cooled to; Fine straining after thick worry, thick worry gauze used is 200 orders, and fine straining selects cake filtration (more than 800 orders), and gained filtrate is Chinese medicine extract of the present invention.
Measure pH value to filtrate after sucking filtration, solid content, measurement result is: pH value is 6.0-7.0, solid content 15-25%; 85 DEG C are incubated 30 minutes afterwards, and water-bath is cooled to room temperature, obtains product.Afterwards as required, can subsequent operation be carried out, as sterilization, fill etc.
Embodiment 3
The preparation three of Chinese medicine extract of the present invention
(1) each crude drug is taken according to following proportioning;
Radix Salviae Miltiorrhizae 10 grams, Flos Lonicerae 10 grams, Herba Menthae 5 grams, Flos Chrysanthemi Indici 5 grams, the Radix Astragali 5 grams and Flos Caryophylli 5 grams, Radix Sophorae Flavescentis 10 grams, Stigma Croci 5 grams and Herba Violae 5 grams.
(2) crude drug being added percent by volume is 60% EtOH Sonicate pretreatment, and the mass volume ratio (g/mL) of crude drug and ethanol is 1:30.Namely add 1800mL ethanol, ultrasonic pretreatment time is 30 minutes; This ultrasonic pretreated ultrasonic frequency is 50kHz, and power is 160W.
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted: be heated to 50 DEG C, and stirring and refluxing extracts 60min, reclaims extracting solution; Second time reflux, extract, the mass volume ratio (g/mL) of raw material and ethanol is 1:20, and temperature is 50 DEG C, and stirring and refluxing extracts 60min, stops heating, collects the extracting solution of twice;
(4) 45 DEG C are cooled to; Fine straining after thick worry, thick worry gauze used is 200 orders, and fine straining selects cake filtration (more than 800 orders), and gained filtrate is Chinese medicine extract of the present invention.
Measure pH value to filtrate after sucking filtration, solid content, measurement result is: pH value is 6.0-7.0, solid content 15-25%; 85 DEG C are incubated 30 minutes afterwards, and water-bath is cooled to room temperature, obtains product.Afterwards as required, can subsequent operation be carried out, as sterilization, fill etc.
Embodiment 4
The preparation of Chinese medicine preparation of the present invention (tablet)
Take Radix Salviae Miltiorrhizae 100 grams, Flos Lonicerae 100 grams, Herba Menthae 50 grams, Flos Chrysanthemi Indici 50 grams, the Radix Astragali 50 grams and Flos Caryophylli 50 grams, Herba Portulacae 50 grams, Cortex Dictamni 50 grams and Flos Campsis 100 grams.Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Portulacae are pulverized, all the other Six-elements decoct with water twice, and collecting decoction is condensed into thick paste, add above-mentioned powder and granulate, dry, arrange, add magnesium stearate, tabletting, coating.
Embodiment 5
The preparation of Chinese medicine preparation of the present invention (capsule)
Take Radix Salviae Miltiorrhizae 100 grams, Flos Lonicerae 100 grams, Herba Menthae 50 grams, Flos Chrysanthemi Indici 50 grams, the Radix Astragali 50 grams and Flos Caryophylli 50 grams, Herba Portulacae 50 grams, Cortex Dictamni 50 grams and Flos Campsis 100 grams.Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Portulacae are pulverized, all the other Six-elements decoct with water twice, 3 hours first times, second time 2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.15 (70-80 DEG C), add above-mentioned powder, mixing, dry, pulverize into fine powder, encapsulated.
Embodiment 6
The preparation of mosquito-repellent perfume of the present invention
Raw material and proportioning (mass percent):
| Title | Addition |
| Ethanol | 70％ |
| Extract in embodiment 3 | 12％ |
| Trehalose | 1％ |
| Pantothenylol | 0.2％ |
| Citric acid | 0.1％ |
| Sodium citrate | 0.1％ |
| Deionized water | To 100% |
Technique:
(1) Chinese medicine extract is prepared according to the raw material dosage of embodiment 2 and method;
(2) by stirring and dissolving after water-soluble for trehalose post-heating to 80 DEG C, the extract that 50 DEG C add preparation in pantothenylol and embodiment 2 is once cooled to;
(3) temperature is down to 45 DEG C and is added ethanol, citric acid and sodium citrate once, stirs and can obtain product.
(4) product is carried out disinfection, the subsequent handlings such as packaging.
Embodiment 7
The preparation two of floral water of the present invention
Raw material and proportioning (mass percent):
| Title | Addition |
| Ethanol | 70％ |
| Extract in embodiment 3 | 12％ |
| Trehalose | 1％ |
| Pantothenylol | 0.2％ |
| Citric acid | 0.1％ |
| Sodium citrate | 0.1％ |
| Deionized water | To 100% |
Technique:
(1) Chinese medicine extract is prepared according to the raw material dosage of embodiment 3 and method;
(2) by stirring and dissolving after water-soluble for trehalose post-heating to 80 DEG C, the extract that 50 DEG C add preparation in pantothenylol and embodiment 2 is once cooled to;
(3) temperature is down to 45 DEG C and is added ethanol, citric acid and sodium citrate once, stirs and can obtain product.
(4) product is carried out disinfection, the subsequent handlings such as packaging.
Efficacy test
One, materials and methods
For examination floral water: adopt the floral water according to method preparation described in embodiment 5 and embodiment 6, common floral water and common Chinese floral water on market.
Two, for experiment worm kind and experimental condition:
1, mosquito kind: Aedes albopictus (Aedes albopictus), normal lines, 4-5 days female adult mosquitos after sprouting wings;
2, mosquito number: 400 female insects of not sucking blood.First jejunitas 18 hours of experiment.Attack is qualified.
3, attack method of testing: be respectively in length, width and height in the mosquito cage of 40CM, 30CM, 30CM and put into 400 examination worms, testing crew arm exposes 4CM × 4CM skin area, and remainder tightly covers.Stretched into by arm in cage and place 2 minutes, record comes to stop the mosquito number fallen, and being greater than 30 persons is that attack is qualified, and this testing crew and this cage mosquito may be used for test
4, condition: laboratory temperature: 25-27 DEG C
Three, assay method:
1, antipruritic effect: selected qualified subjects 60 example is divided into three groups immediately: this product group, common floral water group, common Chinese floral water group, often organizes each 20 examples.Three groups of experimenters are described above, and wherein a hands exposes 4CM × 4CM skin area, puts into the qualified mosquito cage of attack 2 minutes.60 routine subjects are by after female one-tenth mosquito bite, and local is red and swollen, heat, bitterly, itch, and according to biting degree, quantity, position, spray mosquito bite place 3-8 time every 3 hours with each group of corresponding floral water, for three days on end, and observation antipruritic effect.
2, repelling effect: selected qualified subjects 60 example is divided into three groups immediately: this product group, common floral water group, common Chinese floral water group, often organizes each 20 examples.Three groups of experimenters are described above; its both hands respectively expose 4CM × 4CM skin area; wherein an arm is set to blank, does not do any smearing, and another arm uses the floral water corresponding to respective group; be placed on after 2 hours in the mosquito cage that test provides; continue two minutes, per hourly afterwards to carry out once, the number of times of record mosquito bite; thus guard time is bitten in observation, judges repelling effect.
Four, result of the test
Test shows, the subjects average of this product group 8 minutes can be antipruritic, can subside a swelling in 1 day; And common floral water, only have the function of aromatic mosquito-expelling and refrigerant miliaria of dispelling, repeatedly applied in 3 days, the effect of repellent antipruritic is not remarkable, illustrates that the antipruritic effect of this product is better; The anophelifuge effective protecting time of this product is between 8 hours to 10 hours, and the effective protecting time of general mill run is between 4 to 6 hours, and the repelling effect of this product is obviously better than other mill runs.
Although the present invention is described by embodiment, embodiment is not used for limiting the present invention.Those skilled in the art in scope of the present invention, can make various distortion and improvement, and what therefore protection scope of the present invention should define with the claims of the application is as the criterion.
Claims (9)
1. one kind has the Chinese medicine composition of mosquito-expelling and antipruritic effect, it is characterized in that, described compositions is made up of the crude drug of following weight: Radix Salviae Miltiorrhizae 15-30 weight portion, Flos Lonicerae 10-30 weight portion, Flos Chrysanthemi Indici 10-30 weight portion, Herba Menthae 10-30 weight portion, Radix Astragali 15-30 weight portion, Flos Caryophylli 10-30 weight portion, Cortex Dictamni 10-20 weight portion, Flos Campsis 10-20 weight portion, Herba Portulacae 10-20 weight portion.
2. one kind has the Chinese medicine composition of mosquito-expelling and antipruritic effect, it is characterized in that, described compositions is made up of the crude drug of following weight: Radix Salviae Miltiorrhizae 15-30 weight portion, Flos Lonicerae 10-30 weight portion, Flos Chrysanthemi Indici 10-30 weight portion, Herba Menthae 10-30 weight portion, Radix Astragali 15-30 weight portion, Flos Caryophylli 10-30 weight portion, Stigma Croci 10-20 weight portion, Radix Sophorae Flavescentis 10-20 weight portion, Herba Violae 10-20 weight portion.
3. a Chinese medicine preparation, is characterized in that, by Chinese medicine composition described in claim 1,2, it adds that on pharmaceutics, the extraction of acceptable adjuvant is prepared from.
4. a floral water, is characterized in that, main component contained by it is ethanol, Chinese medicinal plant extract, trehalose, pantothenylol, citric acid, sodium citrate and deionized water; Wherein, described Chinese medicinal plant extract is selected from two or more following materials: Radix Salviae Miltiorrhizae extract, Radix Astragali extract, Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Folium Menthae extract, Flos Caryophylli extract.
5. floral water as described in claim 4, it is characterized in that, described Chinese medicinal plant extract also comprises two or more following materials: Cortex Dictamni extract, Flos Campsis extract, Herba portulacae extract.
6. floral water as described in claim 4, it is characterized in that, described Chinese medicinal plant extract also comprises two or more following materials: Radix Sophorae Flavescentis extract, Stigma Croci extract, Herba Violae extract.
7. a floral water combination, is characterized in that, combined by the floral water described in claim 5 and claim 6.
8. as described in the floral water as described in claim 4,5,6 and claim 7, floral water combination, is characterized in that making external spraying agent or aerosol.
9. a floral water using method, it is characterized in that, floral water as claimed in claim 7 is used to combine, at mosquito bite place, first use floral water as claimed in claim 5, if be not effective, then use the floral water described in claim 6 at mosquito bite place, if be not effective, then within 10 seconds, use the floral water as described in claim 5 and 6 simultaneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210315409.3A CN103655718B (en) | 2012-08-30 | 2012-08-30 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210315409.3A CN103655718B (en) | 2012-08-30 | 2012-08-30 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103655718A CN103655718A (en) | 2014-03-26 |
| CN103655718B true CN103655718B (en) | 2015-02-18 |
Family
ID=50295277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210315409.3A Expired - Fee Related CN103655718B (en) | 2012-08-30 | 2012-08-30 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103655718B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989595B (en) * | 2014-04-30 | 2016-04-13 | 卜明珍 | A kind of natural florida water for children |
| CN104958516A (en) * | 2015-06-03 | 2015-10-07 | 刘强 | Detumescence and itching relieving liquid |
| CN105012179A (en) * | 2015-07-16 | 2015-11-04 | 陆开云 | Mosquito-repelling traditional Chinese medicine and preparation method of traditional Chinese medicine |
| CN105106278A (en) * | 2015-09-17 | 2015-12-02 | 黄冈师范学院 | Chinese herbal medicine sterilization and disinfection lotion and preparation method thereof |
| CN105380844A (en) * | 2015-11-23 | 2016-03-09 | 梁秀萍 | Neroli essential oil floral water and preparation method thereof |
| CN105326704A (en) * | 2015-11-23 | 2016-02-17 | 梁秀萍 | Lavender essential oil floral water and preparation method thereof |
| CN105342918A (en) * | 2015-11-23 | 2016-02-24 | 梁秀萍 | Folium artemisiae argyi floral water and preparation method thereof |
| CN105326703A (en) * | 2015-11-23 | 2016-02-17 | 梁秀萍 | Realgar floral water and preparation method thereof |
| CN105287296A (en) * | 2015-11-23 | 2016-02-03 | 梁秀萍 | Chamomile essential oil floral water and preparation method thereof |
| CN105534871A (en) * | 2016-02-17 | 2016-05-04 | 广西大学 | Mosquito-repelling and itching-relieving floral water and preparation method thereof |
| CN106138241B (en) * | 2016-08-22 | 2018-11-20 | 雷允上药业集团有限公司 | A kind of Chinese medicine composition and preparation method thereof for relieving itching and eliminating swelling after bite by mosquitos |
| CN107213049A (en) * | 2017-04-24 | 2017-09-29 | 广西大学 | A kind of repellent antipruritic floral water |
| CN107213050A (en) * | 2017-04-24 | 2017-09-29 | 广西大学 | A kind of floral water containing plant component and preparation method thereof |
| CN107232187A (en) * | 2017-06-23 | 2017-10-10 | 骆琦 | Careless plant mosquito-repellent spray liquid of one kind hundred and preparation method thereof |
| CN107582475A (en) * | 2017-11-08 | 2018-01-16 | 黄琪淋 | Asian puccoon mosquito repellent liquid |
| CN110755346A (en) * | 2019-10-31 | 2020-02-07 | 洪雅县瓦屋山药业有限公司 | Mosquito-repelling and itching-relieving Coptis deltoidea toilet water and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347395B (en) * | 2008-09-12 | 2010-07-14 | 南京巴黎贝丽丝香水有限公司 | Chinese medicine floral water for preventing and treating bite by mosquitos |
| CN102247442A (en) * | 2011-06-13 | 2011-11-23 | 北京华夏众芳生物科技有限公司 | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof |
-
2012
- 2012-08-30 CN CN201210315409.3A patent/CN103655718B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347395B (en) * | 2008-09-12 | 2010-07-14 | 南京巴黎贝丽丝香水有限公司 | Chinese medicine floral water for preventing and treating bite by mosquitos |
| CN102247442A (en) * | 2011-06-13 | 2011-11-23 | 北京华夏众芳生物科技有限公司 | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中西医结合治疗结节性痒疹68例;许进等;《河北中医》;20090331;第31卷(第3期);408 * |
| 青草淡香型中药精油驱蚊新剂型的研究;李易非等;《西北药学杂志》;20091231;第24卷(第6期);471 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103655718A (en) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103655718B (en) | Traditional Chinese medicine composition, preparation, and floral water and application method thereof | |
| CN101347395B (en) | Chinese medicine floral water for preventing and treating bite by mosquitos | |
| CN102178844B (en) | Oral Chinese medicine preparation for treating gum swelling and pain and preparation method thereof | |
| CN102139030B (en) | Oral Chinese herbal preparation for treating gingivitis and preparation method thereof | |
| CN103655245B (en) | Mosquito repelling flora water | |
| CN105284936A (en) | Mosquito-repellent composition and preparation method thereof | |
| CN105724462A (en) | Electric mosquito-repellent incense liquid and preparation method | |
| CN106727032A (en) | A kind of multi-functional hydrosol and preparation method thereof | |
| CN102247442B (en) | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof | |
| CN104857290A (en) | Traditional Chinese medicine disinfection ointment for treating scalds and burns and preparation method thereof | |
| Laldinsanga et al. | Traditional anti-malarial drugs from Serchhip and Lunglei districts of Mizoram | |
| CN114342965A (en) | Traditional Chinese medicine composition for repelling mosquitoes and preparation method thereof | |
| KR20030077509A (en) | A hygienic band and manufacturing include chinese herb medicine a composite | |
| CN106806758A (en) | A kind of Chinese medicine preparation for treating acne | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN104706840A (en) | Compound tea tree essential oil for preventing and treating mosquito bite | |
| CN105796468A (en) | Preparation method of Vanilla peanigoeia Ancer toilet water | |
| CN113521142A (en) | Pharmaceutical composition for treating seborrheic dermatitis, preparation method and application thereof, and head bath soaking agent and preparation method thereof | |
| CN112022947A (en) | Bacteriostatic agent based on traditional Chinese herbal medicines and small molecular compounds, and preparation method and application thereof | |
| JPH02264663A (en) | Aromatic deodorant | |
| KR100561271B1 (en) | High consistency herb medicine extracted liquid of Artimisiawormwoodand its processed spray/aerosol | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN109432244A (en) | A kind of Chinese medicine preparation and its preparation method and application improving sensitive skin state | |
| Dhar et al. | Medicinal Plants of India | |
| Goswami et al. | A critical review on traditional herbal plant ‘tulsi’ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150218 Termination date: 20160830 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |