CN108743511B - Skin care composition for relieving allergic skin, resisting inflammation and irritation - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/602—Glycosides, e.g. rutin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a skin care composition for relieving allergic skin, resisting inflammation and irritation, and aims to provide a composition capable of effectively relieving symptoms of dryness, redness, fever, pruritus and the like of the allergic skin, wherein the technical scheme mainly comprises the following components in parts by weight: 0.5-3 parts of hesperidin methyl chalcone, 1-8 parts of gentian extract and 3-10 parts of bamboo extract; the bamboo extract is a mixed extract of green-skin bamboo and Qulpart bamboo; belongs to the technical field of skin care products.
Description
Technical Field
The invention discloses a skin care composition, particularly relates to a skin care composition capable of relieving allergic skin and having anti-inflammatory and anti-irritation effects, and belongs to the technical field of skin care products.
Background
Skin sensitivity, which is generally regarded as not a skin disease in medicine, refers to a skin condition with subjective sensory symptoms induced by susceptibility to various factors, i.e., high skin reactivity, poor tolerance, and even susceptibility to allergy. Sensitive skin occurs mainly on the face, as well as on other parts of the hands, feet, scalp, etc. As for daily conditions, sensitive skin has no objective skin lesions or evidence of skin disease, and is mainly characterized by being drier, easily tense and red; the mild stimulation can produce the feelings of pruritus, desquamation, even burning and stabbing pain, and the serious people can produce bad mood or mental symptoms. Climate change, air pollution and cosmetic types and ingredients are complicated, increasing the likelihood of sensitive skin appearing and receiving irritation.
By investigation, more than 40% of the world population indicates that they have "sensitive skin", 55% for european women considered to belong to sensitive skin, 50% for american women (south america and north america) and 65% for african women.
In recent years, the population for purchasing cosmetics is rapidly increased, consumers are increasingly concerned about skin sensitivity and related skin problems caused by the skin sensitivity, the field becomes a hot point for research of the cosmetic industry and the medical industry, and great attention and investment of a plurality of cosmetic companies and scientific research works at home and abroad are caused. At present, products used by people with sensitive skin are released by all major brands in the cosmetic market, but few products can effectively relieve the sensitive skin. Even anti-allergic cosmetics have poor effects, or the product itself contains an allergen, or even hormone components are added to the cosmetics to provide the product with anti-allergic effects, and long-term use of the product causes epidermal atrophy, pigmentation, and the like, resulting in irreversible damage to the skin.
Disclosure of Invention
The invention mainly aims to provide a skin care composition for relieving allergic skin, resisting inflammation and irritation, which can effectively relieve symptoms of dryness, redness, fever, pruritus and the like of the allergic skin.
Therefore, the technical scheme provided by the application is as follows:
a skin care composition for relieving allergic skin, resisting inflammation and irritation mainly comprises the following components in parts by weight: 0.5-3 parts of hesperidin methyl chalcone, 1-8 parts of gentian extract and 3-10 parts of bamboo extract; the bamboo extract is the mixed extract of green-skin bamboo and Qulpart bamboo.
Further, the skin care composition capable of relieving allergic skin, resisting inflammation and resisting irritation further comprises 1-4 parts of an extract of leaves of lemon gugjiang vine.
Furthermore, the skin care composition for relieving allergic skin, resisting inflammation and resisting irritation also comprises 0.5-3 parts of the extract of tilia europaea.
Furthermore, the skin care composition for relieving allergic skin, resisting inflammation and resisting irritation also comprises 0.5-3 parts of the extract of the seed of the cypress.
Further, the skin care composition capable of relieving allergic skin, resisting inflammation and resisting irritation is composed of the following components in parts by weight: 2 parts of hesperidin methyl chalcone, 5 parts of radix gentianae extract, 6 parts of bamboo extract, 2.5 parts of lemon gudgeon vine leaf extract, 1.5 parts of European basswood extract and 1.5 parts of Chinese juniper seed extract.
Furthermore, the skin care composition for relieving allergic skin, resisting inflammation and irritation is prepared from the bamboo extract by the following steps:
respectively cleaning, drying and crushing the green tangerine peel bamboo stems and the Quipara Sasa, sieving the green tangerine peel bamboo stems and the Quipara Sasa with a sieve of 100 meshes and 150 meshes, uniformly mixing the green tangerine peel bamboo stems and the Quipara Sagittifolia according to the mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 to 3 times at the ultrasonic frequency of 50 to 70kv, wherein the material-liquid ratio of each extraction is 1 (5-10), the extraction temperature is 50 to 70 ℃, the extraction time is 20 to 40min, filtering, combining filtrates, concentrating and drying in vacuum, dissolving the dried powder in a proper amount of deionized water to ensure that the mass concentration of active ingredients is 0.5 to 2 percent, and thus obtaining the bamboo extract.
Compared with the prior art, the technical scheme provided by the invention has the following technical effects:
1. the composition provided by the invention mainly adopts hesperidin methyl chalcone, a gentian extract and a bamboo extract, and the synergistic effect of various components is adopted, so that the skin is subjected to allergy relieving, inflammation relieving, swelling diminishing, pain relieving and itching, burning, stabbing pain and other symptoms of sensitive skin are obviously reduced, and the composition has a remarkable repairing effect on cell damage caused by itching; and reducing DNA damage and inflammatory cell damage caused by UVB to human skin fibroblasts, and reducing the occurrence of symptoms of skin allergic reaction caused by ultraviolet rays, such as sunburn, edema, phototoxicity and photoreaction; moreover, the cream can supplement moisture and nutrition in time, relieve the symptoms of dryness, easy tension and redness of allergic skin, and simultaneously reduce the release of anti-inflammatory factors LPS (IL-8, TNF-a) or TNF-a (NF-kb) to achieve better anti-inflammatory effect; meanwhile, the capillary system of the skin is strengthened, the toughness of the capillary is enhanced, so that the permeability of the capillary is reduced, the blood leakage caused by inflammation messengers can be reduced immediately, and the symptoms of redness, erythema and the like of allergic skin are relieved.
2. The skin care composition further has the synergistic anti-inflammatory effect, the antioxidant effect and the anti-saccharification effect by adding the lemon gudgeon vine leaf extract, the hesperidin methyl chalcone, the gentian extract and the bamboo extract.
3. The skin care composition disclosed by the invention is further added with the extract of the European basswood and the extract of the seed of the Japanese juniper, and the scientific formula further enhances the function of blood vessel strengthening, effectively reduces the irritation reaction of the skin to the allergen, and relieves the symptoms of redness and erythema of the skin and the like.
In summary, the technical scheme provided by the application can achieve the effects of supplementing moisture and nutrition, resisting inflammation and strengthening blood vessels, so that the symptoms of dryness, tightness, desquamation, pruritus, burning, stabbing pain, edema, redness, erythema and the like of allergic skin can be effectively relieved, and the effects of resisting inflammation and stimulation can be achieved.
Detailed Description
The following claims are presented in further detail with reference to the embodiments, but not to be construed as limiting the invention in any way, and any number of modifications which may be made by anyone within the scope of the claims are within the scope of the claims.
It should be noted that the raw materials used in the technical scheme provided by the invention are prepared by conventional means or purchased from commercial sources except for special instructions.
Hesperidin methyl chalcone is available from Xianting trade company, Guangzhou city, gentian extract is available from Shanghai Gaizu biotechnology company, lemon Guajiang vine leaf extract is available from Guangzhou Huizu biotechnology company, and Europe basswood extract and Juniperus communis seed extract are available from Aoyuan trade company, Guangzhou city.
Example 1
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 0.5g of hesperidin methyl chalcone, 8g of gentian extract and 3g of bamboo extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems with green tangerine peels and pink quintet, sieving the bamboo stems with a 100-mesh sieve, uniformly mixing the bamboo stems and the pink quintet according to the mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 3 times at the ultrasonic frequency of 50kv, wherein the material-liquid ratio of each extraction is 1:5, the extraction temperature is 70 ℃, the extraction time is 20min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving the dried powder in a proper amount of deionized water to ensure that the mass concentration of active ingredients is 2%, and thus obtaining the bamboo extract.
Example 2
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 3g of hesperidin methyl chalcone, 1g of gentian extract and 10g of bamboo extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving with a 150-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 70kv and a material-liquid ratio of 1:10 for each extraction, carrying out extraction at 50 ℃ for 40min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 0.5%, and thus obtaining the bamboo extract.
Example 3
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 2g of hesperidin methyl chalcone, 5g of gentian extract and 6g of bamboo extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving with a 120-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 60kv and a material-liquid ratio of 1:7 for each extraction, carrying out extraction at 60 ℃ for 30min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 1.2%, and thus obtaining the bamboo extract.
Example 4
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 2g of hesperidin methyl chalcone, 3g of radix gentianae extract, 7g of bamboo extract and 1g of lemon vine leaf extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving by a 100-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 50kv and a material-liquid ratio of 1:8 for each extraction, carrying out extraction at 60 ℃ for 30min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 0.8%, and thus obtaining the bamboo extract.
Example 5
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 1g of hesperidin methyl chalcone, 6g of gentian extract, 4g of bamboo extract and 3 parts of tilia europaea extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving by a 150-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 70kv and a material-liquid ratio of 1:9 for each extraction, carrying out extraction at a temperature of 70 ℃ for 20min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 1.8%, and thus obtaining the bamboo extract.
Example 6
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 2.5g of hesperidin methyl chalcone, 2g of gentian extract, 8g of bamboo extract and 0.5g of Selaginella moellendorfii hieron seed extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving by a 100-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 60kv and a material-liquid ratio of 1:6 for each extraction, carrying out extraction at 70 ℃ for 20min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 0.6%, and thus obtaining the bamboo extract.
Example 7
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 0.8g of hesperidin methyl chalcone, 6g of gentian extract, 5g of bamboo extract, 4g of lemon vine and leaf extract and 0.5g of European basswood extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving with a 120-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 3 times at an ultrasonic frequency of 50kv and a material-liquid ratio of 1:7 for each extraction, carrying out extraction at 60 ℃ for 30min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 1.4%, and thus obtaining the bamboo extract.
Example 8
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 2.7g of hesperidin methyl chalcone, 3g of gentian extract, 9g of bamboo extract, 2g of lemon vine and leaf extract and 3g of Selaginella moellendorfii hieron seed extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving with a 150-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 70kv and a material-liquid ratio of 1:5 for each extraction, carrying out extraction at 60 ℃ for 35min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 0.6%, and thus obtaining the bamboo extract.
Example 9
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: 2.2g of hesperidin methyl chalcone, 3g of gentian extract, 7.2g of bamboo extract, 1g of tilia mandshurica extract and 1g of juniper wood seed extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving with a 120-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 60kv and a material-liquid ratio of 1:7 for each extraction, carrying out extraction at 60 ℃ for 30min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 0.6%, and thus obtaining the bamboo extract.
Example 10
The invention provides a skin care composition for relieving allergic skin, resisting inflammation and irritation, which comprises the following components in parts by weight: a skin care composition for relieving allergic skin, resisting inflammation and irritation comprises the following components in parts by weight: 2g of hesperidin methyl chalcone, 5g of radix gentianae extract, 6g of bamboo extract, 2.5g of lemon vine and leaf extract, 1.5g of European basswood extract and 1.5g of Selaginella moellendorfii hieron seed extract.
Wherein the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing bamboo stems of green tangerine peel and Quipaht pink bamboo, sieving with a 120-mesh sieve, uniformly mixing according to a mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 times at an ultrasonic frequency of 60kv and a material-liquid ratio of 1:7 for each extraction, carrying out extraction at 60 ℃ for 30min, filtering, combining filtrates, concentrating, carrying out vacuum drying, dissolving dried powder in an appropriate amount of deionized water to ensure that the mass concentration of active ingredients is 1.2%, and thus obtaining the bamboo extract.
Comparative example 1
Only 2g of hesperidin methyl chalcone is contained.
Comparative example 2
Only 5g of gentian extract was contained.
Comparative example 3
Only 6g of bamboo extract was contained, and the preparation method of the bamboo extract was the same as that of example 3.
Comparative example 4
Contains 2.5g of extract of vine leaf of lemon, 1.5g of extract of European basswood and 1.5g of extract of seed of cypress of juniper.
To better illustrate the efficacy of a soothing, anti-inflammatory, and anti-irritant skin care composition provided by the present invention, a trial efficacy test of the present invention is provided below.
Clinical experiments
anti-Histamine (HIS) and immunoglobulin e (ige) studies:
histamine (HIS) is one of the self-active substances with various physiological activities widely distributed in the body, and is an important mediator for allergic reactions, which can cause degranulation of these cells when the body is subjected to physicochemical stimuli or allergic reactions, resulting in histamine release. Immunoglobulin E (IgE) refers to an antibody of human body, and is present in serum, the content of IgE in the serum of normal human is lower, and the content of IgE in the serum is obviously higher than that of normal human, so that the content of IgE in the serum is too high, which usually indicates the existence of genetic allergic constitution or type I allergy.
The compositions of examples 1 to 10 and comparative examples 1 to 4 were prepared as test sample solutions using deionized water as 6% aqueous solutions, respectively.
In the experiment, 160 SD rats were selected and randomly divided into 16 groups of 10 rats, namely a normal group, a model group, an example 1-example 10 group and a comparative 1-comparative 4 group. The animals were depilated 24 hours before the experiment and had their backs depilated to an area of about 3cm by 3 cm. The skin of the back of rats was molded with 2, 4-Dinitrochlorobenzene (DNCB) in each group except the normal group and irradiated with ultraviolet rays for 12 hours, after the molding was successful (the skin showed symptoms of dryness, desquamation, burning, stabbing pain, swelling, erythema, etc.). The normal and model groups were each coated with 0.5ml of deionized water on the back depilated area over a range of about 2.5cm by 2.5cm, and the remaining groups were each coated with 0.5ml of a different group of test sample solutions once a day for 14 consecutive days. On day 15, the skin condition of the right back of each group of rats was visually observed and recorded according to the test criteria of table 1, and the concentrations of HIS and IgE in each sample serum were measured.
TABLE 1 test criteria for skin reactions
| 1) Skin dryness and desquamation | Score value |
| No dryness and desquamation | 0-<0.5 |
| Slightly dry without desquamation | 0.5-<2 |
| Moderate dryness, slight desquamation | 2-<3 |
| Severe dryness and desquamation | 3-4 |
| 2) Burning and stabbing pain of skin | Score value |
| No burning and stabbing pain | 0-<0.5 |
| Slight burning and stabbing pain | 0.5-<2 |
| Moderate burning and stabbing pain | 2-<3 |
| Severe burningStabbing pain | 3-4 |
| 3) Swelling of the skin | Score value |
| Without edema | 0-<0.5 |
| Mild edema (barely visible) | 0.5-<2 |
| Moderate edema | 2-<3 |
| Severe edema | 3-4 |
| 4) Erythema of the skin | Score value |
| No erythema | 0-<0.5 |
| Slight erythema (barely visible) | 0.5-<2 |
| Moderate erythema (erythema powder or small) | 2-<3 |
| Severe erythema (purplish red) | 3-4 |
TABLE 2 Effect of test sample solutions on HIS and IgE concentrations in samples
The statistical result shows that the concentrations of HIS and IgE in the serum of the rat in the model group are obviously higher than those in the normal group, and the statistical significance is very obvious; after the sample solutions of the compositions of examples 1-10 of the invention are applied, the concentrations of HIS and IgE are obviously lower than those of a model group, and allergic symptoms are obviously relieved and almost recovered to a normal level, which shows that the composition of the invention has obvious anti-inflammatory and anti-irritation efficacies, and can well relieve allergic skin and symptoms such as skin dryness, desquamation, burning, stabbing pain, swelling, erythema and the like caused by ultraviolet irradiation; and especially, the composition of the example 10 has the best effect, the concentrations of HIS and IgE in the serum of the rat are not obviously different from those in the normal group, and the skin allergy symptoms disappear; although the concentrations of HIS and IgE were reduced after the test sample solutions applied with the compositions of comparative examples 1-4, the concentrations were significantly lower than the changes of the examples, and the allergic symptoms were only slightly relieved, which indicates that hesperidin methylchalcone, gentian extract, bamboo extract, uncaria citri sinensis extract, linden extract, and hinoki wood seed extract in the composition of the present invention have synergistic effects, and when they were compounded in a specific ratio, the composition of the present invention effectively achieved the effects of relieving the allergic skin symptoms and anti-inflammatory and anti-irritation.
Claims (5)
1. The skin care composition capable of relieving allergic skin, resisting inflammation and resisting irritation is characterized by mainly comprising the following components in parts by weight: 0.5-3 parts of hesperidin methyl chalcone, 1-8 parts of gentian extract and 3-10 parts of bamboo extract;
the bamboo extract is the extract of the mixture of green-skin bamboo and Qulpaertea bambusicola;
the bamboo extract is prepared by the following steps:
respectively cleaning, drying and crushing the green tangerine peel bamboo stems and the Quipara Sasa, sieving the green tangerine peel bamboo stems and the Quipara Sasa with a sieve of 100 meshes and 150 meshes, uniformly mixing the green tangerine peel bamboo stems and the Quipara Sagittifolia according to the mass ratio of 1:1, adding absolute ethyl alcohol, carrying out ultrasonic extraction for 2 to 3 times at the ultrasonic frequency of 50 to 70kv, wherein the material-liquid ratio of each extraction is 1 (5-10), the extraction temperature is 50 to 70 ℃, the extraction time is 20 to 40min, filtering, combining filtrates, concentrating and drying in vacuum, dissolving the dried powder in a proper amount of deionized water to ensure that the mass concentration of active ingredients is 0.5 to 2 percent, and thus obtaining the bamboo extract.
2. The skin care composition for soothing allergic skin, diminishing inflammation and resisting irritation as claimed in claim 1, further comprising 1 to 4 parts of an extract of leaves of caragana lemongensis.
3. The skin care composition for soothing sensitive skin, relieving inflammation and resisting irritation according to claim 1, further comprising 0.5-3 parts of extract of tilia europaea.
4. The skin care composition for soothing sensitive skin, relieving inflammation and resisting irritation as claimed in claim 1, further comprising 0.5-3 parts of Cupressus Sempervirens seed extract.
5. The skin care composition for soothing sensitive skin, relieving inflammation and resisting irritation as claimed in claim 1, wherein the composition comprises the following components in parts by weight: 2 parts of hesperidin methyl chalcone, 5 parts of radix gentianae extract, 6 parts of bamboo extract, 2.5 parts of lemon gudgeon vine leaf extract, 1.5 parts of European basswood extract and 1.5 parts of Chinese juniper seed extract.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811027944.2A CN108743511B (en) | 2018-09-04 | 2018-09-04 | Skin care composition for relieving allergic skin, resisting inflammation and irritation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811027944.2A CN108743511B (en) | 2018-09-04 | 2018-09-04 | Skin care composition for relieving allergic skin, resisting inflammation and irritation |
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| Publication Number | Publication Date |
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| CN108743511A CN108743511A (en) | 2018-11-06 |
| CN108743511B true CN108743511B (en) | 2021-03-30 |
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| CN108078902A (en) * | 2018-02-01 | 2018-05-29 | 广州鹰远生物科技有限公司 | A kind of essence lotion containing Flos persicae extract |
| CN108158910A (en) * | 2018-03-13 | 2018-06-15 | 艾因特丽（苏州）生物科技有限公司 | A kind of polypeptide compound formulation with senile-resistant efficacy and its preparation method and application |
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