CN112006934A - Cosmetic compound with mild acne removing effect and application thereof - Google Patents
Cosmetic compound with mild acne removing effect and application thereof Download PDFInfo
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- CN112006934A CN112006934A CN202010920477.7A CN202010920477A CN112006934A CN 112006934 A CN112006934 A CN 112006934A CN 202010920477 A CN202010920477 A CN 202010920477A CN 112006934 A CN112006934 A CN 112006934A
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- salicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a compound with a mild acne removing effect, and belongs to the technical field of cosmetics. Comprises the following components: anionic organic acids, amino acid cation derivatives and kava plant extract. In the use process of the compound, the kava plant extract can act on nerve endings, can occupy sensitive information receptors on the skin to block neuron transmission information, can inhibit the transmission of sensitivity generated by the pressure of a nervous system caused by external attack on the skin, achieves the effect of immediately relieving skin irritation and reduces the irritation of the compound to the skin. Meanwhile, the anionic organic acid and the amino acid cation derivative are combined to a certain degree to form a new compound, so that the concentration of free salicylic acid in the solution is reduced, the irritation to the skin is reduced, when the unbound salicylic acid in the system is consumed, the compound can slowly release the salicylic acid to continuously play a role, and the acne removing effect of the compound can be ensured on the premise of reducing the irritation to the skin.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic compound with a mild acne removing effect and application thereof.
Background
The acne is caused by excessive sebum secretion, hyperkeratosis of pilosebaceous ducts, unsmooth cutin metabolism, blockage of hair follicle openings, excessive proliferation of anaerobic propionibacterium acnes, inflammation such as red swelling and stabbing pain and the like, and acne is generated. It has been thought that acne heals after adolescence, but recently, it has been reported that people who are affected by acne are increasing after 20 years of adolescence. As can be seen, the demand for anti-acne cosmetics is increasing. At present, the vitamin A acid medicines and the antibiotic medicines are mainly used in combination for local or systemic use clinically, but the long-term use of antibiotics causes the resistance of the propionibacterium acnes to the antibiotics to be increasingly serious. Salicylic acid is often used as a keratolytic agent for removing excess stratum corneum which blocks pores and preventing sebum from remaining in hair follicles. However, salicylic acid has two problems:
(1) the salicylic acid can pry the keratotic plug blocking the pore, introduce oxygen, inhibit anaerobic propionibacterium acnes from multiplying to a great extent, and achieve the effects of removing acne, diminishing inflammation and cleaning the skin. However, salicylic acid is used as micromolecular acid, has strong permeability and strong irritation to microvasculature and nerves distributed among deep skins;
(2) for sensitive skin with skin lesions, the feeling of experience with salicylic acid products is not good.
Disclosure of Invention
1. Technical problem to be solved by the invention
The invention aims to solve the problems that the existing cosmetics can stimulate the skin in the acne removing process and the acne removing effect is poor.
2. Technical scheme
In order to achieve the purpose, the technical scheme provided by the invention is as follows:
the compound with the mild acne removing effect comprises the following components: anionic organic acids, amino acid cation derivatives and kava plant extract.
Preferably, the anionic organic acid is salicylic acid;
the amino acid cation derivative is specifically PCA cocoyl arginine ethyl ester salt
And/or
Lauroyl arginine ethyl ester HCl.
Preferably, the mass content of each component is as follows: salicylic acid 0.01-2 parts, kava plant extract 0.001-10 parts,
0.01-1 part of PCA cocoyl arginine ethyl ester salt
And/or
0.01-1 part of lauroyl arginine ethyl ester HCl.
Preferably, the mass ratio of the salicylic acid to the kava plant extract is 10: 1-1: 50.
Preferably, when the PCA cocoyl arginine ethyl ester salt and the lauroyl arginine ethyl ester HCl exist simultaneously, the mass ratio of the PCA cocoyl arginine ethyl ester salt to the lauroyl arginine ethyl ester HCl is 1: 10-10: 1.
Preferably, the mass ratio of the anionic organic acid to the amino acid cation derivative is 1: 1-1: 5.
The application of the compound with the mild acne removing effect in skin care products and cosmetics.
The application of the compound with the mild acne removing effect in the aspect of acne removing.
3. Advantageous effects
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
the compound with the mild acne removing effect comprises the following components: anionic organic acids, amino acid cation derivatives and kava plant extract. In the use process of the compound, the kava plant extract can act on nerve endings, can occupy sensitive information receptors on the skin to block neuron transmission information, can inhibit the transmission of sensitivity generated by the pressure of a nervous system caused by external attack on the skin, achieves the effect of immediately relieving skin irritation and reduces the irritation of the compound to the skin. Meanwhile, the anionic organic acid and the amino acid cation derivative are combined to a certain degree to form a new compound, so that the concentration of free salicylic acid in the solution is reduced, the irritation to the skin is reduced, when the unbound salicylic acid in the system is consumed, the compound can slowly release the salicylic acid to continuously play a role, and the acne removing effect of the compound can be ensured on the premise of reducing the irritation to the skin.
Detailed Description
The present invention will now be described more fully hereinafter with reference to the accompanying examples, in which, however, the invention may be embodied in many different forms and is not limited to the examples described herein, but rather are provided for the purpose of providing a more thorough disclosure of the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention; as used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example 1
The compound with mild acne removing efficacy comprises the following components: anionic organic acids, amino acid cation derivatives and kava plant extract. In the use process of the compound, the kava plant extract can act on nerve endings, can occupy sensitive information receptors on the skin to block neuron transmission information, can inhibit the transmission of sensitivity generated by the pressure of a nervous system caused by external attack on the skin, achieves the effect of immediately relieving skin irritation and reduces the irritation of the compound to the skin. Meanwhile, the anionic organic acid and the amino acid cation derivative are combined to a certain degree to form a new compound, so that the concentration of free salicylic acid in the solution is reduced, the irritation to the skin is reduced, when the unbound salicylic acid in the system is consumed, the compound can slowly release the salicylic acid to continuously play a role, and the acne removing effect of the compound can be ensured on the premise of reducing the irritation to the skin.
The amino acid cation derivative of the embodiment is specifically PCA cocoyl arginine ethyl ester, and the salicylic acid, the PCA cocoyl arginine ethyl ester and the kava plant extract of the embodiment are 0.01 part, 0.01 part and 2 parts respectively.
Example 2
The compound with mild acne removing efficacy comprises the following components: anionic organic acid, amino acid cation derivative and kava plant extract, wherein salicylic acid is 0.01 part, lauroyl arginine ethyl ester HCl is 0.01 part, and kava plant extract is 2 parts.
Example 3
The compound with mild acne removing efficacy comprises the following components: the composition comprises 0.01 part of salicylic acid, 0.01 part of lauroyl arginine ethyl ester HCl, 0.01 part of PCA cocoyl arginine ethyl ester salt and 2 parts of kava plant extract.
Example 4
The skin care cosmetic with the mild acne removing effect adopts the compound, and comprises the following components: salicylic acid 0.01 parts, kava plant extract 0.1 parts, PCA cocoyl arginine ethyl ester salt 0.01 parts, lauroyl arginine ethyl ester HCl0.01 parts, and other unconventional skin care cosmetics, wherein the conventional skin care cosmetics are the basic cost of the skin care cosmetics, and detailed description is not provided for the prior art
The compound prepared in examples 1 to 3 and the skin care cosmetic prepared in example 4 were administered to 50 patients with acne on their faces, 25 of them each, and the effects were as follows after one week:
as can be seen from the above, the use of the products of examples 1 to 4 not only has low irritation to the facial skin, but also has good effect of treating pox, and also has a certain effect of eliminating pox marks, because the anionic organic acid in the composition of the present invention is salicylic acid, which dissolves the inter-cuticular constituent substance (pigment) and causes the cuticle to fall off, thus removing the cuticle which is excessively thick and accumulating, and promoting metabolism.
Among them, the metabolism of the skin: the main function of the stratum corneum is to protect the cells of each layer of the skin, and the metabolism of the epidermal cells of one layer and another layer naturally progresses outward, and the outermost layer of keratinocytes naturally crumbles down after they gradually age and harden. Old keratin, which is not normally exfoliated, makes the skin rough and dull, slows the metabolism of the skin, and even forms comedones to block pores. Salicylic acid can remove redundant horny layer and promote the rapid renewal of epidermal cells; if the epidermal cells are all fresh and full of vital tender cells, the skin can naturally recover smooth and delicate.
In addition, salicylic acid is fat-soluble and can permeate into deep layer of pore along sebaceous gland which secretes fat, and is beneficial to dissolving old accumulated horny layer in pore, improving pore blocking condition, thus blocking acne and shrinking enlarged pore. The salicylic acid acts on cells of the hair follicle wall, can help to remove blocked hair follicles and correct abnormal cell shedding, can prevent the hair follicles from being blocked for slight acnes, is most effective for blackheads, can reduce the phenomenon that the hair follicle wall is abnormally shed, prevents new focuses from being generated, and has the function of removing acnes.
The mass contents of the components in this example are: 0.01-2 parts of salicylic acid, 0.01-1 part of PCA cocoyl arginine ethyl ester salt, 0.01-1 part of lauroyl arginine ethyl ester HCl and 0.1-10 parts of kava plant extract. Less than 0.01 part of salicylic acid has no acne removing effect, and more than 2 parts of salicylic acid has high irritation; less than 0.01 part of PCA cocoyl arginine ethyl ester salt and less than 1 part of lauroyl arginine ethyl ester HCl have no effect, and the concentration of salicylic acid in the solution is reduced so as to reduce the acne removing efficacy; less than 0.1 part of kava extract has no skin sensitivity inhibiting effect, and more than 10 parts of kava extract has high skin irritation.
Since salicylic acid is a weak acid, in salicylic acid solutions
Ionized C6H4(OH) COO-Complex with amino acid cation derivatives:
when the solution reaches the equilibrium, every part of salicylic acid in the system is consumed, the compound releases one part of the conjugate base C6H4(OH) COO-of the salicylic acid to form the salicylic acid.
According to the method, the anionic organic acid and the amino acid cation derivative are combined to a certain degree to form a new compound, and the concentration of free salicylic acid in the solution is reduced, so that the irritation to the skin is reduced, when the unbound salicylic acid in the system is consumed, the compound can slowly release the salicylic acid to continuously play a role, and the acne removing effect of the compound can be ensured on the premise of reducing the irritation to the skin.
Therefore, the mass ratio of the salicylic acid to the kava plant extract is 1: 10-1: 50, the mass ratio of the PCA cocoyl arginine ethyl ester salt to the lauroyl arginine ethyl ester HCl is 2: 1-1: 2, and the mass ratio of the anionic organic acid to the amino acid cation derivative is 1: 1-1: 5. Can effectively ensure that the concentration of salicylic acid contained in the compound can ensure that the compound has good effect of treating the pox on the premise of low irritation.
To demonstrate the sustained release effect of salicylic acid, the following experiments were performed:
(1) purpose of the experiment:
and verifying whether the complex formed by the salicylic acid and the amino acid cation has the effect of slowly releasing the salicylic acid.
(2) Preparing:
two samples were divided into 5ml each for control 1 and control 2, and 0.1% aqueous sodium citrate solution was prepared.
(3) Experimental method and experimental procedure:
6 drops of 0.1% sodium citrate aqueous solution are respectively added into the control group 1 and the control group 2 by a dropper, the pH value is detected once every drop, and the test process and the pH detection data are shown in the following table:
the experimental results are as follows:
the pH value of the sodium citrate aqueous solution added into the control group 1 is stably maintained at about 4.40 after being reduced,
control 2 had a continuous increase in pH with the addition of aqueous sodium citrate.
And (4) experimental conclusion:
in the control group 1, when the alkaline sodium citrate aqueous solution is added, the salicylic acid is neutralized, but the pH does not rise and drop, so that the complex begins to slowly release the salicylic acid to ensure that the pH is maintained in a certain range to play a role when the salicylic acid which is not combined into the complex in the system is consumed;
in the control group 2, when the alkaline sodium citrate aqueous solution is added, the salicylic acid is neutralized and consumed, the pH value is continuously increased, and the system is proved to have no effect of slowly releasing the salicylic acid.
The amino acid cation derivative can form a complex with salicylic acid, and when the salicylic acid in the system is consumed, the system can slowly release the salicylic acid to continuously play a role, so that the irritation to the skin is reduced.
The above-mentioned embodiments only express a certain implementation mode of the present invention, and the description thereof is specific and detailed, but not construed as limiting the scope of the present invention; it should be noted that, for those skilled in the art, without departing from the concept of the present invention, several variations and modifications can be made, which are within the protection scope of the present invention; therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. The compound with mild acne removing effect is characterized by comprising the following components: anionic organic acids, amino acid cation derivatives and kava plant extract.
2. The composition with mild acne removing efficacy according to claim 1, wherein: the anionic organic acid is salicylic acid;
the amino acid cation derivative is specifically PCA cocoyl arginine ethyl ester salt
And/or
Lauroyl arginine ethyl ester HCl.
3. The compound with mild acne removing effect according to claim 2, wherein the mass content of each component is as follows: salicylic acid 0.01-2 parts, kava plant extract 0.001-10 parts,
0.01-1 part of PCA cocoyl arginine ethyl ester salt
And/or
0.01-1 part of lauroyl arginine ethyl ester HCl.
4. The composition with mild acne removing efficacy according to claim 3, wherein: the mass ratio of the salicylic acid to the kava plant extract is 10: 1-1: 50.
5. The composition with mild acne removing efficacy according to claim 3, wherein: when the PCA cocoyl arginine ethyl ester salt and the lauroyl arginine ethyl ester HCl exist at the same time, the mass ratio of the PCA cocoyl arginine ethyl ester salt to the lauroyl arginine ethyl ester HCl is 1: 10-10: 1.
6. The composition with mild acne removing efficacy according to claim 3, wherein: the mass ratio of the anionic organic acid to the amino acid cation derivative is 1: 1-1: 5.
7. The application of the compound with mild acne removing effect is characterized in that: use of a complex according to any one of claims 1 to 6 in skin care and cosmetic applications.
8. The application of the compound with mild acne removing effect is characterized in that: use of a complex according to any one of claims 1 to 6 for the treatment of acne.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010920477.7A CN112006934A (en) | 2020-09-04 | 2020-09-04 | Cosmetic compound with mild acne removing effect and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010920477.7A CN112006934A (en) | 2020-09-04 | 2020-09-04 | Cosmetic compound with mild acne removing effect and application thereof |
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| CN112006934A true CN112006934A (en) | 2020-12-01 |
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| CN202010920477.7A Pending CN112006934A (en) | 2020-09-04 | 2020-09-04 | Cosmetic compound with mild acne removing effect and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494474A (en) * | 2020-12-22 | 2021-03-16 | 江苏美爱斯化妆品股份有限公司 | Complexes containing alpha-hydroxy acids and uses thereof |
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| WO1999025369A1 (en) * | 1997-11-17 | 1999-05-27 | Sederma S.A. | Compositions for cosmetic and dermopharmaceutical use containing a plant extract obtained from kava piper methysticum roots |
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| CN106821862A (en) * | 2017-03-23 | 2017-06-13 | 广州市花安堂生物科技有限公司 | A kind of acne-removing composition and preparation method thereof |
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-
2020
- 2020-09-04 CN CN202010920477.7A patent/CN112006934A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999025369A1 (en) * | 1997-11-17 | 1999-05-27 | Sederma S.A. | Compositions for cosmetic and dermopharmaceutical use containing a plant extract obtained from kava piper methysticum roots |
| CN106562892A (en) * | 2016-10-27 | 2017-04-19 | 广州市花安堂生物科技有限公司 | Anti-corrosion composition without addition of chemical synthetic preservatives, application of anti-corrosion composition and cosmetics prepared from anti-corrosion composition |
| CN106821862A (en) * | 2017-03-23 | 2017-06-13 | 广州市花安堂生物科技有限公司 | A kind of acne-removing composition and preparation method thereof |
| CN107737033A (en) * | 2017-09-27 | 2018-02-27 | 广州市花安堂生物科技有限公司 | A kind of quick anti-acne and anti-acne print composition and preparation method thereof |
| CN110420266A (en) * | 2019-08-11 | 2019-11-08 | 广州川研化学科技有限公司 | A kind of three green pepper anti-acne anti-mite agent |
| CN111481456A (en) * | 2020-04-23 | 2020-08-04 | 广州伊尔美生物科技有限公司 | Soothing composition |
Non-Patent Citations (2)
| Title |
|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494474A (en) * | 2020-12-22 | 2021-03-16 | 江苏美爱斯化妆品股份有限公司 | Complexes containing alpha-hydroxy acids and uses thereof |
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Application publication date: 20201201 |