CN110075034A - Pure plant antiseptic composition, preparation method and the application in facial mask - Google Patents
Pure plant antiseptic composition, preparation method and the application in facial mask Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The present invention relates to a kind of pure plant antiseptic composition, preparation method and the application in facial mask, the raw material components of the pure plant antiseptic composition include: Gentrin Knotweed P.E 5-15 parts by weight, pepper extract 5-15 parts by weight, chrysanthemum extract 5-15 parts by weight, Rosmarinus officinalis extract 5-15 parts by weight, licorice 5-15 parts by weight, tea extract 2-5 parts by weight.Pure antiseptic composition of the present invention is compounded by six kinds of pure plant extracts, pass through the synergistic effect between each component, there is significant bacteriostasis to various pathogens, the present invention is made of pure plant natural component, do not add polyalcohol, it applied in facial mask, can be tested by preservation challenge, while there is high safety in utilization.
Description
Technical field
The invention belongs to daily use chemicals technical fields, and in particular to a kind of pure plant antiseptic composition, preparation method and
Application in facial mask.
Background technique
With the continuous improvement of people's living standards, having higher requirement to cosmetics.In recent years, it produces a kind of new
Cosmetic forms-facial mask, facial mask is by the skin, while passing through gravity, infiltration for the attachment for a long time of a large amount of Essence
The factors such as pressure, so that skin quickly keeps the skin wet and nutrition, effect is got instant result, and the market demand is in explosive growth in recent years,
As one of skin care item most popular at present.
However, large dosage of acts on skin, and facial mask class cosmetics propose higher want to safety due to for a long time
It asks.According to Market Feedback, preservative is the main arch-criminal of facial mask allergy.
Protective system in facial mask experienced following several stages:
First stage, using the protective system of other cosmetics categories: methylisothiazolinone, methyl hydroxybenzoate, Bu Luobo
That, diazonium imidazolidinyl urea etc..Based on the reasons such as clinical data and genotoxicity, most preservative is all classified as by European Union
It is not recommended that using list.In newest formula, these preservatives have also gradually been substituted, few to occur in formula.
Second stage, chemical synthesis, relatively mild and with fungistatic effect substance: Typical Representative is fragrant acyl ketone (to hydroxyl
Benzoylformaldoxime) and decoyl hydroximic acid.This substance is proven to have not in " cosmetic art specification " preservative list
Preferable fungistatic effect, many facial masks, as preservative efficacy, are declared to be not added with anti-using such substance inside final products
Rotten agent.In order to accomplish broad-spectrum antibacterial effect, usual this kind of material demand and polyalcohol (propylene glycol, butanediol, pentanediol, oneself two
Alcohol, pungent glycol, Phenoxyethanol etc.) or some plant antiseptic agents compounded to improve antiseptic effect.In recent years, this kind of anti-
Rotten system is widely used, and reduces traditional preservatives bring irritation to a certain extent, but a large amount of data in the market
It confirms, this substance is still with the presence of more people's allergic conditions.
The protective system that plant antiseptic agent is compounded with polyalcohol: phase III has more document and patent to mention plant
Corrosion-resistant concept, make a general survey of it is all declare antiseptic system, discovery, which all exists, is unable to that broad-spectrum antibacterial, cost be too high, complicated component
The problem of.So most, all to use plant antiseptic agent and polyalcohol (propylene glycol, butanediol, pentanediol, hexylene glycol, pungent
Glycol, Phenoxyethanol etc.) compounding scheme carry out.It is well known, however, that these polyalcohols in face pack prescription it is easy to appear
Fever, scratchy problem.Antiseptic compounds the safety for not solving face pack prescription fundamentally with polyalcohol.
Therefore, it is necessary to develop a pure plant preservative intrinsically safe in face pack prescription.
Summary of the invention
The purpose of the present invention is to provide a kind of pure plant antiseptic composition, the pure antiseptic composition is pure by six kinds
Plant extracts compounds, and by the synergistic effect between each component, has significant bacteriostasis, this hair to various pathogens
It is bright to be made of pure plant natural component, polyalcohol is not added, is applied in facial mask, can be tested by preservation challenge, be had simultaneously
There is high safety in utilization.
Another object of the present invention is to provide the preparation methods of the pure plant antiseptic composition.The pure plant is anti-
In rotten agent composition, each raw extract is all made of ad hoc approach and is prepared, and it is high that the method extracts bacteriostatic activity, impurity at
Divide content low, each raw extract extracted skin safety in utilization with higher is applied in facial mask, target user
It is wider.
The technical solution of the present invention is as follows:
A kind of pure plant antiseptic composition, raw material components include:
Gentrin Knotweed P.E 5-15 parts by weight, pepper extract 5-15 parts by weight, chrysanthemum extract 5-15 parts by weight, rosemary
Extract 5-15 parts by weight, licorice 5-15 parts by weight, tea extract 2-5 parts by weight.
Further, the raw material components of the pure plant antiseptic composition include:
Gentrin Knotweed P.E 8-12 parts by weight, pepper extract 8-12 parts by weight, chrysanthemum extract 8-12 parts by weight, rosemary
Extract 8-12 parts by weight, licorice 8-12 parts by weight, tea extract 2-4 parts by weight.
Further, the raw material components of the pure plant antiseptic composition include:
10 parts by weight of Gentrin Knotweed P.E, 10 parts by weight of pepper extract, 10 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract
10 parts by weight, 10 parts by weight of licorice, 2 parts by weight of tea extract.
Further, each raw extract is extracted as follows and is obtained:
(1) raw material is weighed, after drying, crushing, obtains raw material meal；
(2) ethyl alcohol is added in Xiang Suoshu raw material meal and carries out seepage pressure effects, obtain ethanol percolation liquid；
(3) by the ethanol percolation liquid carry out ultrasonic extraction, after be filtered to remove filter residue, filtrate recycling ethanol, through dense
Contracting, drying, obtain powdered each raw extract.
Further, in step (1), the partial size of the raw material meal is 10-100 mesh.
Further, in step (2), when the raw material is polygonum cuspidate, the concentration of alcohol for carrying out the seepage pressure effects is 85-
95vol%；When the raw material is Chinese prickly ash, the concentration of alcohol of the seepage pressure effects is carried out lower than 20vol%；The raw material is chrysanthemum
When, the concentration of alcohol for carrying out the seepage pressure effects is higher than 95vol%；When the raw material is rosemary, the seepage pressure effects are carried out
Concentration of alcohol be 60-80vol%；When the raw material is Radix Glycyrrhizae, the concentration of alcohol for carrying out the seepage pressure effects is 70-
90vol%；When the raw material is tealeaves, the concentration of alcohol for carrying out the seepage pressure effects is 20-40vol%.
Further, in step (2), the diacolation flow velocity of the seepage pressure effects is 2-5ml/minkg, carries out the diacolation
It extracts to 8-10 times that percolate weight is medicinal material weight.
Further, in step (3), the ultrasonic power of the ultrasonic extraction is 80-400W, the temperature of the ultrasonic extraction
It is 40-60 DEG C, the time of the ultrasonic extraction is 30-60min.
A method of preparing the pure plant antiseptic composition, specific preparation step are as follows: weigh polygonum cuspidate extraction respectively
Object, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice and tea extract, then by each original
Material is uniformly mixed, and the water of 0.8-1.5 times of quality is added, stirs evenly to get the pure plant antiseptic composition.
Application of the pure plant antiseptic composition in facial mask.
To facilitate the understanding of the present invention, now the raw material in the present invention is further elaborated.
Polygonum cuspidate is polygonaceae Polygonum herbaceos perennial.Polygonum cuspidate has relatively broad distribution in China, and anthraquinone spreads out in polygonum cuspidate
The bacteriostasis of biology is very strong.Polydatin energy antibacterium, glucoside member resveratrol can be antimycotic.Tannin has astriction, can make
Microorganism plasm solidifies and has antibacterial action.
A variety of knots such as volatile oil, alkaloid, amide, lignin, cumarin, sterol and fatty acid are contained at Chinese prickly ash, each position
Structure type secondary metabolite has the multiple biological activities such as antioxidant activity, antitumor, anti-inflammatory, desinsection and antibacterial anti-corrosion.
Chrysanthemum is the dry capitulum of composite family Chrysanthemum chrysanthemum group mother chrysanthemum system plant chrysanthemum.Chrysanthemum mainly contains volatile oil, Huang
The ingredients such as ketone, triterpene and organic acid have the pharmacological actions such as antibacterial, anti-oxidant.
Rosemary, mainly contain the oxidation-resistant active ingredients such as rosmanol, Rosmarinic acid, carnosol, carnosic acid and
Volatile oil component, such as 1.8- Cineole, α-and nopinene, amphene, limonene, laurene, α-fishscale bamboo alkene, camphor, borneol, acetic acid
Borneol rouge, α-and beta-terpineol, 4 alcohol of terpinene etc., there is antibacterial antisepsis.
Radix Glycyrrhizae mainly contains glycyrrhizic acid, glycyrrhizic acid, flavones from the root and rhizome of pulse family Glycyrrhiza various plants
Class, mannitol, glucose, sucrose and a small amount of malic acid, betulinic acid, asparagus fern phthalein amine solanic acid, life element, micro volatility
Oil, starch etc..
Tealeaves, the tea polyphenols in tealeaves are a kind of natural polyphenol substances extracted from tealeaves, have good antioxygen
Change and remove the ability of free radical, meanwhile, it is proven to have preferable fungistatic effect.
The invention has the benefit that
Pure plant antiseptic composition of the present invention is compounded by six kinds of pure plant extracts, divides it by each group
Between synergistic effect, there is significant bacteriostasis to various pathogens, the present invention is made of pure plant natural component, do not add more
First alcohol is applied in facial mask, can be tested by preservation challenge, while having high safety in utilization.
The preparation method of pure plant antiseptic composition of the present invention, in the pure plant antiseptic composition, each original
Material extract is all made of ad hoc approach and is prepared, and the method extracts bacteriostatic activity height, and impurity component content is low, thus extracts
Obtained each raw extract skin safety in utilization with higher is applied in facial mask, for a wider population.
Specific embodiment
Below by specific embodiment, the invention will be further described.
1g is represented in following embodiment with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
10 parts by weight of Gentrin Knotweed P.E, 10 parts by weight of pepper extract, 10 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract
10 parts by weight, 10 parts by weight of licorice, 2 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 40 mesh；(2) by the tiger
Cane coarse powder carries out seepage pressure effects with the ethyl alcohol of 90vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 40 mesh；(2) by the flower
Green pepper coarse powder carries out seepage pressure effects with the ethyl alcohol of 16vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 150W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 40 mesh；(2) by the chrysanthemum
Flower coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 200W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Chrysanthemum extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 40 mesh；(2) by institute
It states rosemary coarse powder and carries out seepage pressure effects with the ethyl alcohol of 70vol%, the diacolation flow velocity of the seepage pressure effects is 3ml/minkg,
The seepage pressure effects are carried out to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) ethyl alcohol is seeped
Liquid of filtering carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 100W, and the temperature of the ultrasonic extraction is 50 DEG C, described super
Sound extraction time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtained
Powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 40 mesh；It (2) will be described sweet
Careless coarse powder carries out seepage pressure effects with the ethyl alcohol of 80vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 320W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Licorice；
The tea extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 40 mesh；(2) by the tea
Leaf coarse powder carries out seepage pressure effects with the ethyl alcohol of 30vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 380W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed, the water of 0.8 times of quality is added by extract, stir evenly to get the pure plant anti-corrosion
Agent composition.
Embodiment 2
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
12 parts by weight of Gentrin Knotweed P.E, 12 parts by weight of pepper extract, 12 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract
8 parts by weight, 8 parts by weight of licorice, 3 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 60 mesh；(2) by the tiger
Cane coarse powder carries out seepage pressure effects with the ethyl alcohol of 90vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 60 mesh；(2) by the flower
Green pepper coarse powder carries out seepage pressure effects with the ethyl alcohol of 16vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 150W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 60 mesh；(2) by the chrysanthemum
Flower coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 200W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Chrysanthemum extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 60 mesh；(2) by institute
It states rosemary coarse powder and carries out seepage pressure effects with the ethyl alcohol of 70vol%, the diacolation flow velocity of the seepage pressure effects is 3ml/minkg,
The seepage pressure effects are carried out to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) ethyl alcohol is seeped
Liquid of filtering carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 100W, and the temperature of the ultrasonic extraction is 50 DEG C, described super
Sound extraction time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtained
Powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 60 mesh；It (2) will be described sweet
Careless coarse powder carries out seepage pressure effects with the ethyl alcohol of 80vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 320W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Licorice；
The tea extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 60 mesh；(2) by the tea
Leaf coarse powder carries out seepage pressure effects with the ethyl alcohol of 30vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 380W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed, the water of 1.5 times of quality is added by extract, stir evenly to get the pure plant anti-corrosion
Agent composition.
Embodiment 3
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
8 parts by weight of Gentrin Knotweed P.E, 8 parts by weight of pepper extract, 12 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract 12
Parts by weight, 12 parts by weight of licorice, 3 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 80 mesh；(2) by the tiger
Cane coarse powder carries out seepage pressure effects with the ethyl alcohol of 90vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 80 mesh；(2) by the flower
Green pepper coarse powder carries out seepage pressure effects with the ethyl alcohol of 16vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 150W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 80 mesh；(2) by the chrysanthemum
Flower coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 200W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Chrysanthemum extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 80 mesh；(2) by institute
It states rosemary coarse powder and carries out seepage pressure effects with the ethyl alcohol of 70vol%, the diacolation flow velocity of the seepage pressure effects is 3ml/minkg,
The seepage pressure effects are carried out to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) ethyl alcohol is seeped
Liquid of filtering carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 100W, and the temperature of the ultrasonic extraction is 50 DEG C, described super
Sound extraction time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtained
Powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 80 mesh；It (2) will be described sweet
Careless coarse powder carries out seepage pressure effects with the ethyl alcohol of 80vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 320W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Licorice；
The tea extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 80 mesh；(2) by the tea
Leaf coarse powder carries out seepage pressure effects with the ethyl alcohol of 30vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 380W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed by extract, the water of the quality such as addition stirs evenly to get the pure plant preservative
Composition.
Embodiment 4
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
15 parts by weight of Gentrin Knotweed P.E, 15 parts by weight of pepper extract, 12 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract
12 parts by weight, 12 parts by weight of licorice, 3 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 20 mesh；(2) by the tiger
Cane coarse powder carries out seepage pressure effects with the ethyl alcohol of 90vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 20 mesh；(2) by the flower
Green pepper coarse powder carries out seepage pressure effects with the ethyl alcohol of 16vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 150W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 20 mesh；(2) by the chrysanthemum
Flower coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power 200W of the ultrasonic extraction, the temperature of the ultrasonic extraction are 50 DEG C, the ultrasonic extraction
Time is 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and powdered chrysanthemum is obtained
Flower extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 20 mesh；(2) by institute
It states rosemary coarse powder and carries out seepage pressure effects with the ethyl alcohol of 70vol%, the diacolation flow velocity of the seepage pressure effects is 3ml/minkg,
The seepage pressure effects are carried out to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) ethyl alcohol is seeped
Liquid of filtering carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 100W, and the temperature of the ultrasonic extraction is 50 DEG C, described super
Sound extraction time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtained
Powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 20 mesh；It (2) will be described sweet
Careless coarse powder carries out seepage pressure effects with the ethyl alcohol of 80vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 320W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Licorice；
The tea extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 20 mesh；(2) by the tea
Leaf coarse powder carries out seepage pressure effects with the ethyl alcohol of 30vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 380W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed by extract, the water of the quality such as addition stirs evenly to get the pure plant preservative
Composition.
Embodiment 5
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
8 parts by weight of Gentrin Knotweed P.E, 8 parts by weight of pepper extract, 12 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract 12
Parts by weight, 12 parts by weight of licorice, 4 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 20 mesh；(2) by the tiger
Cane coarse powder carries out seepage pressure effects with the ethyl alcohol of 90vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 20 mesh；(2) by the flower
Green pepper coarse powder carries out seepage pressure effects with the ethyl alcohol of 16vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 150W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 20 mesh；(2) by the chrysanthemum
Flower coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 200W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Chrysanthemum extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 20 mesh；(2) by institute
It states rosemary coarse powder and carries out seepage pressure effects with the ethyl alcohol of 70vol%, the diacolation flow velocity of the seepage pressure effects is 3ml/minkg,
The seepage pressure effects are carried out to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) ethyl alcohol is seeped
Liquid of filtering carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 100W, and the temperature of the ultrasonic extraction is 50 DEG C, described super
Sound extraction time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtained
Powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 20 mesh；It (2) will be described sweet
Careless coarse powder carries out seepage pressure effects with the ethyl alcohol of 80vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 320W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Licorice；
The tea extract extracts obtain with the following method:
(1) dry 3h, crushing under the conditions of 50 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 20 mesh；(2) by the tea
Leaf coarse powder carries out seepage pressure effects with the ethyl alcohol of 30vol%, and the diacolation flow velocity of the seepage pressure effects is 3ml/minkg, carries out institute
Seepage pressure effects are stated to 9 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 380W, and the temperature of the ultrasonic extraction is 50 DEG C, the ultrasonic extraction
Time be 40min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed by extract, the water of the quality such as addition stirs evenly to get the pure plant preservative
Composition.
Embodiment 6
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
5 parts by weight of Gentrin Knotweed P.E, 5 parts by weight of pepper extract, 5 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract 15
Parts by weight, 15 parts by weight of licorice, 5 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 4h, crushing under the conditions of 40 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 10 mesh；(2) by the tiger
Cane coarse powder carries out seepage pressure effects with the ethyl alcohol of 85vol%, and the diacolation flow velocity of the seepage pressure effects is 2ml/minkg, carries out institute
Seepage pressure effects are stated to 8 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 60 DEG C, the ultrasonic extraction
Time be 30min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 4h, crushing under the conditions of 40 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 10 mesh；(2) by the flower
Green pepper coarse powder carries out seepage pressure effects with the ethyl alcohol of 18vol%, and the diacolation flow velocity of the seepage pressure effects is 2ml/minkg, carries out institute
Seepage pressure effects are stated to 8 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 60 DEG C, the ultrasonic extraction
Time be 30min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 4h, crushing under the conditions of 40 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 10 mesh；(2) by the chrysanthemum
Flower coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 2ml/minkg, carries out institute
Seepage pressure effects are stated to 8 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 60 DEG C, the ultrasonic extraction
Time be 30min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Chrysanthemum extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 4h, crushing under the conditions of 40 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 10 mesh；(2) by institute
It states rosemary coarse powder and carries out seepage pressure effects with the ethyl alcohol of 60vol%, the diacolation flow velocity of the seepage pressure effects is 2ml/minkg,
The seepage pressure effects are carried out to 8 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) ethyl alcohol is seeped
Liquid of filtering carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 80W, and the temperature of the ultrasonic extraction is 60 DEG C, described super
Sound extraction time be 30min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtained
Powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 4h, crushing under the conditions of 40 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 10 mesh；It (2) will be described sweet
Careless coarse powder carries out seepage pressure effects with the ethyl alcohol of 70vol%, and the diacolation flow velocity of the seepage pressure effects is 2ml/minkg, carries out institute
Seepage pressure effects are stated to 8 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 60 DEG C, the ultrasonic extraction
Time be 30min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Licorice；
The tea extract extracts obtain with the following method:
(1) dry 4h, crushing under the conditions of 40 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 10 mesh；(2) by the tea
Leaf coarse powder carries out seepage pressure effects with the ethyl alcohol of 20vol%, and the diacolation flow velocity of the seepage pressure effects is 2ml/minkg, carries out institute
Seepage pressure effects are stated to 8 times that percolate liquid weight is medicinal material weight, obtain ethanol percolation liquid；(3) by the ethanol percolation liquid into
Row ultrasonic extraction, the ultrasonic power of the ultrasonic extraction are 80W, and the temperature of the ultrasonic extraction is 60 DEG C, the ultrasonic extraction
Time be 30min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, and is obtained powdered
Tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed, the water of 1.2 times of quality is added by extract, stir evenly to get the pure plant anti-corrosion
Agent composition.
Embodiment 7
The present embodiment provides a kind of pure plant antiseptic composition, raw material components include:
15 parts by weight of Gentrin Knotweed P.E, 15 parts by weight of pepper extract, 15 parts by weight of chrysanthemum extract, Rosmarinus officinalis extract
5 parts by weight, 5 parts by weight of licorice, 2 parts by weight of tea extract；
The Gentrin Knotweed P.E extracts obtain with the following method:
(1) dry 2h, crushing under the conditions of 60 DEG C by polygonum cuspidate, obtains the polygonum cuspidate coarse powder that partial size is 100 mesh；It (2) will be described
Polygonum cuspidate coarse powder carries out seepage pressure effects with the ethyl alcohol of 95vol%, and the diacolation flow velocity of the seepage pressure effects is 5ml/minkg, carries out
The seepage pressure effects obtain ethanol percolation liquid to 10 times that percolate liquid weight is medicinal material weight；(3) by the ethanol percolation liquid
Ultrasonic extraction is carried out, the ultrasonic power of the ultrasonic extraction is 400W, and the temperature of the ultrasonic extraction is 40 DEG C, the ultrasound extraction
The time taken be 60min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtains powder
Shape Gentrin Knotweed P.E；
The pepper extract extracts obtain with the following method:
(1) dry 2h, crushing under the conditions of 60 DEG C by Chinese prickly ash, obtains the Chinese prickly ash coarse powder that partial size is 100 mesh；It (2) will be described
Chinese prickly ash coarse powder carries out seepage pressure effects with the ethyl alcohol of 16vol%, and the diacolation flow velocity of the seepage pressure effects is 5ml/minkg, carries out
The seepage pressure effects obtain ethanol percolation liquid to 10 times that percolate liquid weight is medicinal material weight；(3) by the ethanol percolation liquid
Ultrasonic extraction is carried out, the ultrasonic power of the ultrasonic extraction is 400W, and the temperature of the ultrasonic extraction is 40 DEG C, the ultrasound extraction
The time taken be 60min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtains powder
Shape pepper extract；
The chrysanthemum extract extracts obtain with the following method:
(1) dry 2h, crushing under the conditions of 60 DEG C by chrysanthemum, obtains the chrysanthemum coarse powder that partial size is 100 mesh；It (2) will be described
Chrysanthemum coarse powder carries out seepage pressure effects with the ethyl alcohol of 96vol%, and the diacolation flow velocity of the seepage pressure effects is 5ml/minkg, carries out
The seepage pressure effects obtain ethanol percolation liquid to 10 times that percolate liquid weight is medicinal material weight；(3) by the ethanol percolation liquid
Ultrasonic extraction is carried out, the ultrasonic power of the ultrasonic extraction is 400W, and the temperature of the ultrasonic extraction is 40 DEG C, the ultrasound extraction
The time taken be 60min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtains powder
Shape chrysanthemum extract；
The Rosmarinus officinalis extract extracts obtain with the following method:
(1) dry 2h, crushing under the conditions of 60 DEG C by rosemary, obtains the rosemary coarse powder that partial size is 100 mesh；(2) will
The rosemary coarse powder carries out seepage pressure effects with the ethyl alcohol of 80vol%, and the diacolation flow velocity of the seepage pressure effects is 5ml/min
Kg carries out the seepage pressure effects to 10 times that percolate liquid weight is medicinal material weight, obtains ethanol percolation liquid；(3) by the second
Alcohol percolation liquid carries out ultrasonic extraction, and the ultrasonic power of the ultrasonic extraction is 400W, and the temperature of the ultrasonic extraction is 40 DEG C, institute
State ultrasonic extraction time be 60min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried,
Obtain powdered Rosmarinus officinalis extract；
The licorice extracts obtain with the following method:
(1) dry 2h, crushing under the conditions of 60 DEG C by Radix Glycyrrhizae, obtains the Radix Glycyrrhizae coarse powder that partial size is 100 mesh；It (2) will be described
Radix Glycyrrhizae coarse powder carries out seepage pressure effects with the ethyl alcohol of 90vol%, and the diacolation flow velocity of the seepage pressure effects is 5ml/minkg, carries out
The seepage pressure effects obtain ethanol percolation liquid to 10 times that percolate liquid weight is medicinal material weight；(3) by the ethanol percolation liquid
Ultrasonic extraction is carried out, the ultrasonic power of the ultrasonic extraction is 400W, and the temperature of the ultrasonic extraction is 40 DEG C, the ultrasound extraction
The time taken be 60min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtains powder
Shape licorice；
The tea extract extracts obtain with the following method:
(1) dry 2h, crushing under the conditions of 60 DEG C by tealeaves, obtains the coarse tea leaf powder that partial size is 100 mesh；It (2) will be described
Coarse tea leaf powder carries out seepage pressure effects with the ethyl alcohol of 40vol%, and the diacolation flow velocity of the seepage pressure effects is 5ml/minkg, carries out
The seepage pressure effects obtain ethanol percolation liquid to 10 times that percolate liquid weight is medicinal material weight；(3) by the ethanol percolation liquid
Ultrasonic extraction is carried out, the ultrasonic power of the ultrasonic extraction is 400W, and the temperature of the ultrasonic extraction is 40 DEG C, the ultrasound extraction
The time taken be 60min, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated under reduced pressure, is spray-dried, obtains powder
Shape tea extract.
Further, a kind of method preparing the pure plant antiseptic composition is provided, is included the following steps:
Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice, tealeaves are weighed respectively
Then each raw material is uniformly mixed, the water of 1.2 times of quality is added by extract, stir evenly to get the pure plant anti-corrosion
Agent composition.
Comparative example 1
Difference with embodiment 1, which is only that, removes Gentrin Knotweed P.E.
Comparative example 2
Difference with embodiment 1, which is only that, removes pepper extract.
Comparative example 3
Difference with embodiment 1, which is only that, removes chrysanthemum extract.
Comparative example 4
Difference with embodiment 1, which is only that, removes Rosmarinus officinalis extract.
Comparative example 5
Difference with embodiment 1, which is only that, removes licorice.
Comparative example 6
Difference with embodiment 1, which is only that, removes tea extract.
Experimental example
One, different concentration ethanol carries out the experimental study of seepage pressure effects
Present inventor further studies between concentration of alcohol in seepage pressure effects and the raw material finally extracted activity
Relationship, first use different concentration ethanol seepage pressure effects, then carry out inhibition zone test, fungistatic effect difference is huge as the result is shown
Greatly.Further according to the analysis, suitable concentration of alcohol is extremely important to the extraction of anti-corrosion effective component in plant, concentration of alcohol choosing
Select proper, the effective component of dissolution is more, and invalid impurity is less.Specific test process is as follows:
1, test specimen
Sample 1: the solution that Gentrin Knotweed P.E and water 1:1 in mass ratio are mixed to get
Sample 2: the solution that pepper extract and water 1:1 in mass ratio are mixed to get
Sample 3: the solution that chrysanthemum extract and water 1:1 in mass ratio are mixed to get
Sample 4: the solution that Rosmarinus officinalis extract and water 1:1 in mass ratio are mixed to get
Sample 5: the solution that licorice and water 1:1 in mass ratio are mixed to get
Sample 6: the solution that tea extract and water 1:1 in mass ratio are mixed to get
2, test strain
Escherichia coli (Escherichia coli) ATCC 8739, staphylococcus aureus (Staphylococcus
Aureus) ATCC 6538, aspergillus niger (Aspergillus niger) ATCC 16404, candida albicans (Candida
albicans)ATCC 10231。
3, inhibition zone test
For each strain after culture medium culture, being diluted to concentration with sterile saline is 106The bacteria suspension of cfu/ml, with nothing
Each strain bacteria suspension is coated on plate made of nutrient agar by bacterium cotton swab respectively；Taking diameter is the sterilizing filter paper disk of 6mm,
Each sample solution is uniformly picked respectively, then is attached on plate made of different bacteria suspensions respectively；Escherichia coli, golden yellow Portugal
Grape coccus is under the conditions of 37 DEG C, aspergillus niger, candida albicans constant temperature incubation 1-3d under the conditions of 28 DEG C, and observation bacterium colony grows feelings
Condition measures antibacterial circle diameter, takes its average value, observes result.
4, evaluation method
Antibacterial circle diameter is bigger, illustrates that fungistatic effect is better.
5, test result: it is shown in Table 1.
Each raw extract inhibition zone test result of table 1
Two, preservative efficacy testing
1, inhibition zone is tested
1.1 test specimen
Examples 1 to 7 pure plant preservative
1.2 test strain
Escherichia coli (Escherichia coli) ATCC 8739, staphylococcus aureus (Staphylococcus
Aureus) ATCC 6538, aspergillus niger (Aspergillus niger) ATCC 16404, candida albicans (Candida
albicans)ATCC 10231。
1.3 inhibition zone test
For each strain after culture medium culture, being diluted to concentration with sterile saline respectively is 106The bacteria suspension of cfu/ml；
Four kinds of bacteria suspensions are coated on plate made of nutrient agar respectively with aseptic cotton carrier；Take the sterilizing filter paper circle that diameter is 6mm
Piece uniformly picks each test specimen respectively, then is attached on plate made of different bacteria suspensions respectively, escherichia coli, golden yellow
Color staphylococcus is under the conditions of 37 DEG C, aspergillus niger, candida albicans constant temperature incubation 1-3d under the conditions of 28 DEG C, observation bacterium colony growth
Situation measures antibacterial circle diameter, takes its average value, observes result.
1.4 evaluation method
Bacteriostatic diameter >=10mm be it is effective, < 10mm is invalid.
1.5 test result
2 inhibition zone test result of table
Test result shows that 1~7 pure plant preservative of the embodiment of the present invention is effective against pathogenic bacteria.
Three, security test
1, rabbit Multiple skin irritation test
Experimental animal rabbit (4) back backbone two sides dorsal body setae is shaved, range 3*3cm, application area 2.5*2.5cm.
1~7 plant antiseptic agent 0.5ml of the embodiment of the present invention is applied on the skin of left side, other side skin is smeared daily as control
1 time, continuously smear 14d.Since the 2nd day, shaving before smearing every time removed residual tested material with warm water, knot is observed after 1 hour
Fruit scores by P491 in cosmetics safety technical specification, and check plot and trial zone are equally handled.It is calculated according to formula daily
Every animal average integral determines skin irritatin intensity by P492 in specification.Multiple skin irritation test the result shows that, the present invention
Pure plant antiseptic composition skin irritation index is non-stimulated.
3 rabbit Multiple skin irritation test result of table
2, human skin patch
35 people of test number, meets subject's standard.Examples 1 to 7 pure plant antiseptic composition is put into spot examination
The small interior of device, dosage are about 0.020~0.025mL.Control wells are blank control (not setting any substance), will be added with tested material
Spot tester is pasted on the back or forearm song side of subject with low sensitization adhesive tape, is gently pressed with palm and is allowed to equably be pasted on skin
On, continue for 24 hours.After removing tested material spot tester 30min (after impression disappearance after), for 24 hours with 48h according to the form below standard sight
Dermoreaction, and record observation result.
4 human skin patch dermoreaction grade scale of table
5 human skin patch test result of table
Four, application of the preservative of the present invention in cosmetics
1, preservation challenge is tested
1.1 sample preparation
6 sample formulations of table
It is specific the preparation method comprises the following steps: by formula ratio water, glycerol, dipropylene glycol, Sodium Hyaluronate, beta glucan, carbomer, small
Pyrenomycetes glue is added sequentially in main cooker, is heated to 85 DEG C, and 2500r/min homogeneous 5min makes to be uniformly dispersed, and keeps the temperature 30min；Then
Start to cool down, when being cooled to 50-60 DEG C, arginine is added, stirs evenly, continues to cool down；When temperature is down to 40 DEG C of addition nerves
Amide lipid body, hydroxyethyl piperazine ethane sulfonic acid, saualane liposome, tetrahydro methylpyrimidine carboxylic acid and preservative, stirring are equal
It is even to get.
1.2 test strain
Bacterium: pseudomonas aeruginosa (Pseudomonas aeruginosa) ATCC 9027, escherichia coli
(Escherichia coli) ATCC 8739, staphylococcus aureus (Staphylococcus aureus) ATCC 6538
Mould: aspergillus niger (Aspergillus niger) ATCC 16404
Saccharomycete: candida albicans (Candida albicans) ATCC 10231
1.3 test method
The primary plus bacterium preservation challenge test recommended using CTFA.Bacterium, mould are disposably accessed into sample a~g
And saccharomycete, bacterium, yeast and mold initial inoculum be 105Cfu/g (ml), it is 37 DEG C that sample, which is deposited in temperature,
Under conditions of (inoculated bacteria) and 28 DEG C (inoculation mould or saccharomycete), regular sampling Detection wherein remaining microorganism.
1.4 evaluation criterion
Bacterium: from initially to 14 days bacterial population log reduction cannot its bacterium be total less than 2.0, and from 14 days to 28
Number not can increase；Mould and saccharomycete: from initially to 14 days and 28 days, mould not can increase with saccharomycete sum；Meet above
Situation then shows that the antibacterial system of the sample has relatively strong or extra-heavy fungistatic effect to microorganism.
1.5 test result
7 results of preservation challenge tests of table
The result shows that the sample a of addition pure plant antiseptic composition of the present invention is from initially to 14 days bacterial population logarithms
Reduced value is greater than 2.0, and at the 14th day after connecing bacterium, bacterium is reduced to not countable, and a day total number of bacteria does not have from 14 days to 28
There is increase；During the test from initially to 14 days and 28 days, mould does not increase with saccharomycete sum.Compared with sample a, sample
B~g preservation challenge effect dies down, and at the 28th day, total number of bacteria, mould and saccharomycete sum can not drop to 10 or less.It says
Bright preservative of the present invention has stronger fungistatic effect for the growth of bacterium and mould, saccharomycete, and between each raw material component
There are certain synergistic effects.
2, safety evaluatio
2.1 prepare sample h~m
Sample h: being only that preservative is different from the difference of sample a, using 0.5% 2 preservative of embodiment
Sample i: being only that preservative is different from the difference of sample a, using 0.5% embodiment, 3 preservative
Sample j: being only that preservative is different from the difference of sample a, using 0.5% embodiment, 4 preservative
Sample k: being only that preservative is different from the difference of sample a, using 0.5% embodiment, 5 preservative
Sample l: being only that preservative is different from the difference of sample a, using 0.5% embodiment, 6 preservative
Sample m: being only that preservative is different from the difference of sample a, using 0.5% embodiment, 7 preservative
Non-woven fabrics face paper is placed in facial mask bag, sample a, sample h~m, 30ml/ bag is then poured into respectively, nothing is made
Woven fabric facial mask.
2.2 test method
It selects 1000 volunteers to test, gives sample a respectively, sample h~m non-woven fabrics facial mask carries out face and sticks
On probation, dermoreaction classification standard is as a result fed back as follows according to skin patch testing standard (being shown in Table 4):
8 sample a of table, sample h~m face result on trial
The result shows that pure plant antiseptic composition of the present invention is applied in facial mask, negative reaction in 1000 experimenters
Number accounting is greater than 99.5%, illustrates that pure plant antiseptic composition of the present invention has high safety in utilization.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of pure plant antiseptic composition, which is characterized in that raw material components include:
Gentrin Knotweed P.E 5-15 parts by weight, pepper extract 5-15 parts by weight, chrysanthemum extract 5-15 parts by weight, rosemary extract
Object 5-15 parts by weight, licorice 5-15 parts by weight, tea extract 2-5 parts by weight.
2. pure plant antiseptic composition according to claim 1, which is characterized in that raw material components include:
Gentrin Knotweed P.E 8-12 parts by weight, pepper extract 8-12 parts by weight, chrysanthemum extract 8-12 parts by weight, rosemary extract
Object 8-12 parts by weight, licorice 8-12 parts by weight, tea extract 2-4 parts by weight.
3. pure plant antiseptic composition according to claim 1, which is characterized in that raw material components include:
10 parts by weight of Gentrin Knotweed P.E, 10 parts by weight of pepper extract, 10 parts by weight of chrysanthemum extract, 10 weight of Rosmarinus officinalis extract
Measure part, 10 parts by weight of licorice, 2 parts by weight of tea extract.
4. pure plant antiseptic composition according to claim 1-3, which is characterized in that each raw material extracts
Object is extracted as follows and is obtained:
(1) raw material is weighed, after drying, crushing, obtains raw material meal；
(2) ethyl alcohol is added in Xiang Suoshu raw material meal and carries out seepage pressure effects, obtain ethanol percolation liquid；
(3) by the ethanol percolation liquid carry out ultrasonic extraction, after be filtered to remove filter residue, filtrate recycling ethanol is concentrated, dry
It is dry, obtain powdered each raw extract.
5. pure plant antiseptic composition according to claim 4, which is characterized in that in step (1), the raw material meal
Partial size be 10-100 mesh.
6. pure plant antiseptic composition according to claim 4, which is characterized in that in step (2), the raw material is tiger
When cane, the concentration of alcohol for carrying out the seepage pressure effects is 85-95vol%；When the raw material is Chinese prickly ash, the seepage pressure effects are carried out
Concentration of alcohol be lower than 20vol%；When the raw material is chrysanthemum, the concentration of alcohol for carrying out the seepage pressure effects is higher than 95vol%；
When the raw material is rosemary, the concentration of alcohol for carrying out the seepage pressure effects is 60-80vol%；When the raw material is Radix Glycyrrhizae, into
The concentration of alcohol of the row seepage pressure effects is 70-90vol%；When the raw material is tealeaves, the ethyl alcohol of the seepage pressure effects is carried out
Concentration is 20-40vol%.
7. pure plant antiseptic composition according to claim 4, which is characterized in that in step (2), the seepage pressure effects
Diacolation flow velocity be 2-5ml/minkg, carrying out the seepage pressure effects to percolate weight is 8-10 times of medicinal material weight.
8. pure plant antiseptic composition according to claim 4, which is characterized in that in step (3), the ultrasonic extraction
Ultrasonic power be 80-400W, the temperature of the ultrasonic extraction is 40-60 DEG C, and the time of the ultrasonic extraction is 30-60min.
9. a kind of method for preparing any one of claim 1-8 pure plant antiseptic composition, which is characterized in that specific system
Standby step are as follows: weigh respectively Gentrin Knotweed P.E, pepper extract, chrysanthemum extract, Rosmarinus officinalis extract, licorice and
Then each raw material is uniformly mixed by tea extract, the water of 0.8-1.5 times of quality is added, stirs evenly to get described pure
Plant antiseptic agent composition.
10. application of the pure plant antiseptic composition in facial mask described in claim 1-8.
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