CN103202797A - Skin care composition and water aqua having acne treatment efficacy and preparation method of water aqua - Google Patents
Skin care composition and water aqua having acne treatment efficacy and preparation method of water aqua Download PDFInfo
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Abstract
The invention provides acne treatment water with acne treatment efficacy and a preparation method of the water. The acne treatment water is prepared by taking traditional Chinese medicine theory of China as a basis, taking skin health as a purpose, taking a composite traditional Chinese medicine extract as a main efficacy additive and taking common substrate components in makeup as assistance. The acne treatment water provided by the invention has bacteriostasis efficacy, and also has the efficacies of removing pathogenic heat from blood, promoting blood, reducing the stagnation, relieving itching, diminishing inflammation and the like. The composite traditional Chinese medicine extract is naturally green, healthy and safe, and can be widely applied to acne treatment cosmetics.
Description
Technical field
The present invention relates to a kind of skin care compositions, specifically a kind of have anti-acne and have the skin care compositions of bacteriostasis efficacy concurrently and water preparation of being prepared by this skin care compositions and preparation method thereof.
Background technology
Comedo is that hair follicle and sebaceous gland are blocked, a kind of chronic inflammatory disease dermatoses that inflammation causes, be common in the youth of both sexes of adolescence, mainly occur in usually good sending out in face, cervical region, chest and back, shoulder and upper arm, form pimple, the traditional Chinese medical science claims " acne ", and the doctor trained in Western medicine name of disease is " acne ".The adolescence androgen increases, and smegma increases, and makes hair follicle, the different hyperkeratosis of sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls the hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture can not freely be discharged skin surface, in hair follicle, form the fat bolt and deposit.When these dyskeratosis cell aggregationes, when expanding, lower hopper just forms ripe acne.The bacterial decomposition that sebum is existed in the hair follicle produces fatty acid, and latter's hair follicle stimulating causes inflammation, and causes the follicular wall damage to be broken, and the hair follicle content enters corium, thereby, cause the hair follicle inflammatory reaction of varying degree on every side.The genesis mechanism of comedo, relevant with following three big factors:
(1) to the agnogenio property aggravation of androgen steroid (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reaction, causes sebum to produce and increase.
(2) propionibacterium acnes hypertrophy.This bacterium is formed for the hair follicle normal flora, and it is its effect machine matter with sebum, and makes it partly to be converted into free fatty.But propionibacterium acnes is the activating complement path also, produces two kinds of chemotactic factors at least, impels inflammation to take place.
(3) the capsular epithelium cell quantity increases, and tackness is arranged, and it is excessive to form the hair follicle tetention keratosis.Latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo forms.
The problem of the product for resolving poxes on the market: 1, easily cause skin allergy, big to skin irritation; 2, add chemical antibacterial and destroy the skin normal flora; 3, add hormones such as some banned substances such as chloromycetin; 4, add heavy metal substance.
To sum up, this area urgent need is a kind of can remedy prior art defective and the good skin care formulation of technique effect.
Summary of the invention
The objective of the invention is to propose a kind of skin care compositions with acne-removing.
A further object of the present invention is to propose a kind of method that above-mentioned skin protection combination room is prepared into water preparation.
Invention thinking of the present invention is:
The present invention utilizes advanced biotechnology, in conjunction with the traditional theory of Chinese medical science of China, Herba Artemisiae Scopariae, the Fructus Kochiae, Cortex Moutan, Galla Chinensis, Spina Gleditsiae, Spica Prunellae are effectively combined, form compound preparation, and with it as active component, be added in the anti-acne water preparation, make it have antibiotic, short infiltration, the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence, thus can effectively prevent and treat dissimilar acnes, give the new life of skin and vigor.
For realizing purpose of the present invention, the present invention adopts following concrete technical scheme:
A kind of skin care compositions with acne-removing, described skin care compositions comprises the raw material of following mass percent:
Described Chinese medicine extract is extracted through the conventional extracting method of the field of Chinese medicines by following raw materials in weight portion medicine and obtains:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 10～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20.
Preferably, described Chinese medicine extract is extracted through following method by following raw materials in weight portion medicine and obtains:
(1) according to following weight parts proportioning weighting raw materials:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 20～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20;
(2) percent by volume is 75%～80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10～1:20, and 60 ℃～70 ℃ heated and stirred 1～2 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10～1:20,60 ℃～70 ℃ of heated and stirred 30min～60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.2g/ml～0.5g/ml, gets concentrate;
(3) according to adding propylene glycol or butanediol in the mass ratio concentrate that to be 1:1～1:2 obtain to step (2), sucking filtration, 3000～5000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
Above-mentioned skin care compositions also comprises the C phase, and described C reaches consumption mutually and is: antiseptic 0.01～0.5wt%.
A kind of above-mentioned skin protection preparation of compositions method processed, described method comprises the steps:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added to the water be heated to 80 ℃～90 ℃ after stirring and evenly mixing cooling;
(2) cool to below 40 ℃, add Chinese medicine extract and stir, namely.
A kind of above-mentioned skin protection preparation of compositions method processed, described method step is as follows:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added to the water stir cooling after being heated to 80 ℃～90 ℃;
(2) cool to below 40 ℃, add antiseptic and Chinese medicine extract and stir, namely.
A kind of skin care formulation with acne-removing, described skin care formulation is made by said method.
The above-mentioned skin care formulation with acne-removing, described skin care formulation are water preparation, and water preparation is skin care field cosmetic water commonly used.
According to use approach difference, Chinese medicine composition of the present invention can be pulverized and mixed makes the powder flush coat, also can be made into other external-use skin care preparations after extracting, as cleansing milk, spray or essence etc.Be not limited to above-mentioned dosage form, can aforementioned pharmaceutical compositions be made various external preparation by known method according to method known in the skin care item industrial circle.
Water preparation of the present invention i.e. cosmetic water in the skin care formulation on ordinary days, recommends using method to be: after clean of every day, the anti-acne water preparation is coated on the skin of pox, massage treats that water slowly absorbs gently.
Useful result of the present invention:
Raw material of the present invention is all selected natural plant composition for use, non-stimulated to skin safe, Chinese medicine extract itself not only has bacteriostasis efficacy, also has clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, antipruritic, effects such as antiinflammatory can be improved the skin microenvironment, fundamentally treat skin problems such as acne, simultaneously, the present invention has excellent prevention and dispels effect pockmark or cicatrix.Raw material of the present invention obtains easily, preparation method is easy, green safety, and anti-acne is effective, is easy to be accepted by consumers in general, has good application prospects and market prospect.
Description of drawings
Fig. 1 anti-acne water sample uses back skin oil and fat changes of contents situation
Fig. 2 anti-acne water sample uses the situation of change of back skin oil and fat increment rate
Fig. 3 anti-acne water sample uses the relative increment rate of back skin oil and fat
Fig. 4 is that anti-acne water is to the inhibition of pimple;
Fig. 5 is that anti-acne water is to the inhibition of pustule;
Fig. 6 anti-acne water uses back first all volunteer's in-service evaluation effects;
Fig. 7 anti-acne water uses back second all volunteer's in-service evaluation effects;
Fig. 8 anti-acne water uses back the 3rd all volunteer's in-service evaluation effects;
Fig. 9 anti-acne water uses volunteer's in-service evaluation effect around the back the;
The back volunteer produced evaluation of effect to preventing pockmark around Figure 10 anti-acne water used.
The specific embodiment
Anti-acne water provided by the invention is to be main additive with the prescription Chinese medicine extract, and it is formulated to be aided with in the cosmetics matrix components commonly used.Used medical material all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Preparation raw material of the present invention source sees Table 1.
Table 1
The preparation of embodiment 1 anti-acne water preparation of the present invention
Raw material and proportioning (mass percent)
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 30g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 20g, Spina Gleditsiae 10g, Spica Prunellae 20g.
(2) percent by volume is 75% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10, and 60 ℃ of heated and stirred 1 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10,60 ℃ of heated and stirred 30min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.2g/ml, gets concentrate;
(3) according to adding propylene glycol in the mass volume ratio g/ml concentrate that to be 1:2 obtain to step (2), sucking filtration, 3000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The preparation of anti-acne water preparation
(1) with stirring and evenly mixing cooling after being heated to 80 ℃ in antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, the allantoin adding deionized water;
(2) cool to below 40 ℃, add described Chinese medicine extract and stir, namely.
The preparation of embodiment 2 anti-acne water preparations of the present invention
Raw material and proportioning (mass percent)
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 20g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 10g, Spina Gleditsiae 20g, Spica Prunellae 10g.
(2) percent by volume is 80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:20, and 70 ℃ of heated and stirred 2 hours are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:20,70 ℃ of heated and stirred 60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.3g/ml, gets concentrate;
(3) according to adding butanediol in the mass volume ratio g/ml concentrate that to be 1:1 obtain to step (2), sucking filtration, 5000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The preparation of anti-acne water preparation:
(1) with stirring and evenly mixing cooling after being heated to 90 ℃ in antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, the allantoin adding deionized water;
(2) cool to below 40 ℃, add described antiseptic and Chinese medicine extract and stir, namely.
The preparation of embodiment 3 anti-acne water of the present invention
Raw material and proportioning (mass percent)
The preparation of Chinese medicine extract:
(1) according to following weight parts proportioning weighting raw materials;
Herba Artemisiae Scopariae 25g, Fructus Kochiae 30g, Cortex Moutan 20g, Galla Chinensis 15g, Spina Gleditsiae 15g, Spica Prunellae 15g.
(2) percent by volume is 75% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:15, and 65 ℃ of heated and stirred 1.5 hours are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:15,65 ℃ of heated and stirred 40min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.5g/ml, gets concentrate;
(3) according to adding propylene glycol or butanediol in the mass volume ratio g/ml concentrate that to be 1:1 obtain to step (2), sucking filtration, 4000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
The preparation of anti-acne water preparation:
(1) with stirring and evenly mixing cooling after being heated to 85 ℃ in antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, the allantoin adding deionized water;
(2) cool to below 40 ℃, add described antiseptic and Chinese medicine extract and stir, namely prepare described skin care formulation.
Effect experiment of the present invention
One. anti-acne water preparation anti-acne effect
The mensuration of antibacterial circle diameter size---filter paper method
1) experimental principle:
On inoculating for examination culture of strains base, impose quantitative sample (embodiment 1 preparation), utilize the scattering and permeating effect of sample in agar culture medium, reach certain limit through sample infiltration diffusion behind the certain hour.In the scope that Mlc reaches, the growth of indicator bacteria just is suppressed, and produces an aseptic transparent region, is called inhibition zone.Parallel the 1,2, the 3rd, the inhibition zone size of sample, one group of experimental data will be done three parallel laboratory tests when generally testing, and last experimental result is to get the meansigma methods of three parallel numerical value as last result.Under certain condition with certain limit in, the diameter of inhibition zone and the logarithm of sample concentration be functional relationship linearly.Utilize this principle, can compare the size of antibacterial virulence, or the working sample content of effective.
2) inhibition zone of external bacteriostatic experiment the results are shown in Table 2
Table 2
| | Parallel | 1 | |
|
Average diameter (mm) |
| Staphylococcus aureus | 18.42 | 18.62 | 18.88 | 18.64 | |
| Staphylococcus epidermidis | 40.42 | 40.92 | 40.22 | 40.52 |
The criterion of external antibacterial qualitative results: antibacterial circle diameter is insensitive (-) less than 8mm, and 8～13mm is low responsive (+), and 13～19mm is medium sensitivity (++), and 19mm is above to be extremely sensitive (+++).It is identical with above-mentioned experimental result that the inventor repeats above-mentioned experimental result with other embodiment products.
2, product control oil effect
1) experimental principle
Human experimentation, the crowd forms test population by particular experiment, test subject makes the variation of the skin oil and fat content before and after (and cosmetic industry composition) of applying some make up, thus determine cosmetics (or functional component) press down the fat effect.
2) experimental apparatus and sample
Experimental apparatus: skin oil and fat tester
Sample: embodiment 1 preparation anti-acne water preparation.
Blank: as to be tried the position and do not use any cosmetics.
3) experiment crowd
The experimenter amounts to 30 people.Concrete sex composition and age structure are determined at random.If there are 2 people untoward reaction to occur, then stop test during this time; The result does not find untoward reaction.
4) experimental technique
1. select experimenter's forehead (branch left and right sides two parts) cycle labeling successively: tried region samples group and blank zone;
2. the technical staff uses the skin oil and fat tester
Averaging in test test position 3-5 time, is designated as initial value.
3. test the position the experimenter and smear sample, use anti-acne water.
4. the experimenter make continuously applied some make up one hour, two hours, four hours after, use the skin oil and fat tester by the technical staff
Measure 3-5 time, average.
5. add up the numerical value that records, analyze its skin oil and fat changes of contents rule.
5) interpretation of result
Fat content changes
The fat content variation is reflected in test period Experimental Area fat content change with time.Its value is more big, and fat content is more big, otherwise fat content is more little.
As Fig. 1, sample sets is compared with the blank group after using 1 hour, and diversity is obvious; Sample used in 4 hours, and the fat content of sample sets is starkly lower than blank group.
The oils and fats increment rate changes
Oils and fats increment rate=(sample sets fat content-initial fat content)/initial fat content
As Fig. 2, in test period, tried the position after sample uses 1 hour, to compare with initial value, skin oil and fat secretion increment rate is starkly lower than blank group, and is lower than blank group always.
Press down the fat rate
The relative increment rate of oils and fats namely presses down fat rate=(sample sets fat content-blank group fat content)/blank group fat content; This value is more little, and it is more obvious to illustrate that the relative blank sample of test specimen presses down the fat effect.
As Fig. 3, in test period, tried after the position uses sample, it presses down the fat rate is negative value always.
6) conclusion
After using sample, the fat secretion amount of being tried the position be starkly lower than do not smear sample be subjected to illustrate that product has the ability that skin oil and fat is secreted that suppresses in the examination zone.It is identical with above-mentioned experimental result that the inventor repeats above-mentioned experimental result with other embodiment products.
3, prevent that pockmark from telling on
1) experimental principle
Pockmark a kind of reparation reaction that to be body produce tissue injury, when the damage of skin reaches corium or large-area skin blemish deeply, the epidermis at this position can not be regenerated, will be by the corium fabric cell, collagen and proliferation of vessels replace, and pockmark so just occurred.The pox scar is because the extruding of infection inflammation or external force forms, and the inflammatory response of Skin Cell has caused the destruction of skin histology and to injure the collagen protein of corium too many, has caused the generation of cicatrix.Therefore improve the skin environment, keep skin elasticity, guarantee that collagen protein not by excessive degradation, can reduce the generation of cicatrix.
(Matrix Metalloproteinases1 MMP-1) is the key enzyme of degrade collagen albumen to matrix metalloproteinase 1, and the activity that suppresses MMP-1 can effectively reduce the collagen protein amount that is degraded, thereby reduces the generation of cicatrix.Therefore the effect that cicatrix is produced of the active reaction plant functional component by vitro inhibition matrix metalloproteinase-1(MMP-1).
Set up MMP-1 enzyme reaction experiment porch, based on this platform, under the prerequisite of destructive enzyme reaction system not, add the plant extract functional component, detect the variation of product fluorescence intensity by the enzyme reaction system, the variation of reflection enzyme activity indirectly, thus reflect that this plant extraction liquid functional component is to the influence of MMP-1 activity.
2) experimental procedure
1. solvent preparation:
(1) preparation buffer (50mmol/L HEPES, 0.12mol/L NaCl, 10mmol/L CaCl2,20 μ mol/L ZnSO4,0.05%Brij-35, pH=7.5),
(2) the MMP-1 proenzyme is standby with buffer gradient dilution to 0.22 μ g/100 μ L;
(3) fluorogenic substrate DQ-gelatin is standby with buffer gradient dilution to 0.20 μ g/100 μ L;
(4) the zymoexcitator APMA of adding 30mmol in the 0.1mol/L of 1L NaOH solution, it is standby to form APMA storing solution (30mmol/L);
(5) embodiment 1 preparation water preparation is mixed with certain density solution for standby;
2.MMP-1 the activation of proenzyme: the volume ratio (MMP:APMA) of MMP-1 proenzyme solution (0.22 μ g/100 μ L) and APMA solution (30mmol/L) being pressed 10:1 is mixed, and hatches the 45min activation at 37 ° of C;
3. application of sample: MMP-1 solution (concentration has been reduced to 0.20 μ g/100 μ L) the 40 μ L that get after the activation add in the 96 hole ELISA Plate, add certain again and treat measuring plants functional component solution 8 μ L, fluorogenic substrate DQ-gelatin solution (0.20 μ g/100 μ L) 52 μ L, making the end reaction system is 100 μ L;
Table 3 vitro inhibition MMP-1 experiment application of sample table
4. constant temperature is hatched: the 96 hole ELISA Plate that will finish application of sample are put into 37 ℃ of incubator constant temperature and are hatched 600s;
5. experimental result detects
(1) be 460nm in excitation wavelength before the reaction, emission wavelength is the fluorescence intensity that detects testing sample (embodiment 1 preparation) under the testing conditions of 520nm;
(2) detect the fluorescence intensity of whole reaction system after reaction system stops to hatch immediately with Bio-Red FLx-800 fluorescence microplate reader, excitation wavelength is 460nm, and emission wavelength is 520nm.
6. Data Processing in Experiment
MMP-1 suppresses percent (%)=[1-(A
1-A
2)/Ao] * 100%
A
1The fluorescence intensity of sample (embodiment 1 preparation) inhibition group is added in-representative
A
2-represent the fluorescence intensity of testing sample self
Ao-the represent fluorescence intensity of blank group
It is more remarkable to the active inhibition of MMP-1 to suppress this kind of plant functional component of the more big expression of percent.
3) experimental result
Chinese medicine extraction liquid is 98.41% to the maximum inhibition of MMP-1 after tested.
Conclusion: this product prevents that pockmark from producing and the desalination pockmark has positive effect.It is identical with above-mentioned experimental result that the inventor repeats above-mentioned experimental result with other embodiment products.
4, the organoleptic indicator of anti-acne effect
Choose 100 volunteers, 13 years old～35 years old age, average 21.5 years old, each 50 of men and women.All there are pimple, pustule, pockmark in face.
Using method: after clean, get an amount of embodiment 1 preparation sample and spread upon the affected part, be massaged into gently to absorb fully and get final product, used for 1 course for the treatment of continuously every day twice, 4 weeks were a course for the treatment of.
Curative effect: skin lesion counting * 100% before curative effect=(skin lesion counting before the treatment-treatment back skin lesion counting)/treatment
Produce effects: skin lesion disappears 60%～90%, sx;
Effectively: skin lesion disappears 20%～60%, doing well,improving;
Invalid: skin lesion disappears＜and 20%, clinical symptoms is not improved;
(1) pimple
As shown in Figure 4, after sample used for first week, its action effect at pimple was obvious, and the effect persistence in 1～3 three week is good.
(2) pustule
As shown in Figure 5, after sample used for 2 weeks, the action effect at pustule of sample was obvious, and lasting lasting effect is arranged.
(3) pockmark
As shown in figure 10, after sample used for 4 weeks, sample prevented that the generation action effect of pockmark is obvious.
(4) conclusion
Comprehensive above test result draws, and its volunteer is after being to use sample:
1) from the vision index directly perceived of skin: pimple, pustule, pockmark are judged, the state that can significantly improve target skin of its sample sets, and the prolongation of the time of using with the volunteer, it improves effect and gradually is and increases progressively trend.
2) shown in Fig. 6 to 9, from volunteer self sensation aspect, along with the increase of the time of using, its volunteer feels particularly evident, certain anti-acne is arranged, prevent the effect that pockmark produces, wherein by detecting last week, namely the volunteer around the feels that effective number reaches 89%.
Claims (9)
1. the skin care compositions with acne-removing is characterized in that, described skin care compositions comprises the raw material of following mass percent:
2. skin care compositions according to claim 1 is characterized in that, described Chinese medicine extract is extracted through the conventional extracting method of the field of Chinese medicines by following raw materials in weight portion medicine and obtains:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 10～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20.
3. skin care compositions according to claim 1 is characterized in that, described Chinese medicine extract is extracted through following method by following raw materials in weight portion medicine and obtains:
(2) according to following weight parts proportioning weighting raw materials:
Herba Artemisiae Scopariae 20～30, the Fructus Kochiae 20～30, Cortex Moutan 10～20, Galla Chinensis 10～20, Spina Gleditsiae 10～20, Spica Prunellae 10～20;
(2) percent by volume is 75%～80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10～1:20, and 60 ℃～70 ℃ heated and stirred 1～2 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10～1:20,60 ℃～70 ℃ of heated and stirred 30min～60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.2g/ml～0.5g/ml, gets concentrate;
(3) according to adding propylene glycol or butanediol in the mass ratio concentrate that to be 1:1～1:2 obtain to step (2), sucking filtration, 3000～5000 rev/mins of centrifuging and taking supernatant are collected filtrate, namely.
4. according to claim 1,2 or 3 described skin care compositionss, it is characterized in that described compositions also comprises the C phase, described C reaches consumption mutually and is: antiseptic 0.01～0.5wt%.
5. a claim 1,2 or 3 described skin protections preparation of compositions method processed is characterized in that described method comprises the steps:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added to the water be heated to 80 ℃～90 ℃ after stirring and evenly mixing cooling;
(2) cool to below 40 ℃, add Chinese medicine extract and stir, namely.
6. the described skin protection of claim 4 preparation of compositions method processed is characterized in that described method step is as follows:
(1) antipruritic and antipruritic agent II, oat polypeptide, butanediol, glycerol, EDTA, allantoin are added to the water stir cooling after being heated to 80 ℃～90 ℃;
(2) cool to below 40 ℃, add antiseptic and Chinese medicine extract and stir, namely.
7. the skin care formulation with acne-removing is characterized in that, described skin care formulation is made by the described method of claim 5.
8. the skin care formulation with acne-removing is characterized in that, described skin care formulation is made by the described method of claim 6.
9. according to claim 7 or 8 described skin care formulations with acne-removing, it is characterized in that described skin care formulation is water preparation.
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| CN105078838A (en) * | 2015-09-10 | 2015-11-25 | 柳超 | Acne-removing lotion and preparation method thereof |
| CN105168478A (en) * | 2015-08-28 | 2015-12-23 | 无限极（中国）有限公司 | Skin care product and preparation method thereof |
| CN105168479A (en) * | 2015-08-28 | 2015-12-23 | 无限极（中国）有限公司 | Acne-removing traditional Chinese medicine composition and preparation method thereof |
| CN105194286A (en) * | 2015-05-28 | 2015-12-30 | 孟宏 | Radiation-proof external skin-care composition and essence with skin barrier repair effect and preparation method thereof |
| CN105193649A (en) * | 2015-05-28 | 2015-12-30 | 孟宏 | Radiation-proof external skin-care composition and lotion with skin barrier repair effect and preparation method thereof |
| CN106381125A (en) * | 2016-08-26 | 2017-02-08 | 华南理工大学 | Chinese herb extract and application thereof in preparing gas hydrate of high gas storage density |
| CN106983693A (en) * | 2017-05-24 | 2017-07-28 | 昆明贝泰妮生物科技有限公司 | A kind of double-deck aqua of the starch granules containing oil-control and preparation method thereof |
| CN108113956A (en) * | 2018-03-05 | 2018-06-05 | 广州市尚昇生物科技有限公司 | A kind of acne removing water and its preparation method and application |
| CN108815035A (en) * | 2018-07-29 | 2018-11-16 | 佛山文森特知识产权服务有限公司 | A kind of refrigerant itching relieving skin care composition |
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| CN108113956A (en) * | 2018-03-05 | 2018-06-05 | 广州市尚昇生物科技有限公司 | A kind of acne removing water and its preparation method and application |
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