KR20180087764A - Feminine cleanser composition comprising potato or potato pulp extract - Google Patents

Abstract

The present invention relates to a feminine cleanser composition comprising a potato extract or a potato pulp extract. It is an object of the present invention to provide the female cleanser composition which is non-toxic and comprises a harmless extract to a human body.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a female detergent composition comprising a potato extract or a potato extract. ≪ Desc / Clms Page number 1 >

The present invention relates to a female detergent composition comprising potato extract or potato extract.

The quality of the woman is the connection between the vulva and the uterus, which is the most humid and warm place in the female body. Therefore, bacteria and fungi, which are the main causes of vaginitis, are suitable for habitat, so the diseases are likely to occur. Under normal conditions, many lactic acid bacteria live in the vagina, making the inside of the vagina mildly acidic and inhibiting the growth of pathogens and molds. However, it is difficult to prevent the growth of pathogens or fungi by using long-term antibiotics, long-term use of pills, use of tampons or loops or pregnancy or childbirth, When the balance inside the vagina breaks down due to hormonal balance changes, vaginitis may occur due to the proliferation of opportunistic pathogens that normally inhibit growth under normal conditions in the vagina.

Vaginitis has been reported as bacterial vaginosis, Candida vaginitis, Trichomonas vaginitis and Atrophic vaginitis. The most common disease is bacterial vaginosis, caused by Gardnerella vaginalis . Candida albicans , common with bacterial vaginosis, is caused by the fungus Candida albicans .

In order to prevent such female diseases, a cleaning agent (vaginal cleanser) and a vulva cleanser are often used. As a local cleaning agent commonly used to prevent vaginitis, a product obtained by sulfonating fatty acids or distilled lauryl alcohol and synthesizing emollients, thickeners, nutrients, foaming agents and organic disinfectants Are being sold. However, the chemical quality detergent has a limitation in that the detergent effect is lowered and the germs are removed instead of removing the germs, and the odor and unpleasant odor removing effect are inhibited. Even if many methods as described above are developed, there is a problem that recurrence occurs well.

In addition, polyene-based drugs such as nystatin, amphotericin B, azole-based drugs such as ketoconazole, miconazole, , And triazole drugs such as itraconazole and fluconazole. However, when the amount of the antibiotics is insufficient, the germs do not die, This results in greater difficulty in subsequent treatment.

Although various drugs have been proposed as methods for treating vaginal cleansing and abnormal symptoms, it is still not enough to present a non-irritating detergent, a cleanser or a drug in consideration that the site of use is the most sensitive mucosal site for external substances . Thus, there is a need to develop new technologies to meet the ongoing need for cleaners using natural extracts without irritation and side effects.

Korean Patent Publication No. 10-2003-004587 Korean Patent Publication No. 10-2006- 002369

It is an object of the present invention to provide a female detergent composition comprising a non-toxic, human-safe extract.

According to an aspect of the present invention, there is provided a female detergent composition comprising potato extract or potato extract.

In the present invention, " potato ( Solanum Tuberosum (Potato) "is one of the world's four major food crops after rice, wheat, and corn grown in 130 countries because of its short growth period, relatively high yield per unit area and relatively high environmental adaptability. Potatoes are not only important as stocks in some countries, they are also used to make a variety of processed products, and consumption of potatoes is on the rise as food culture is westernized.

"Potato leaves ( Solanum Tuberosum (Potato) Pulp) "is a process in which starch is extracted from potatoes and the remaining residue is dried and crushed. The potato and potato starch may contain monosaccharides to promote the growth of lactobacillus bacteria and promote the production of lactic acid which maintains acidity in the vagina, thereby increasing the immunity.

Specifically, the composition of the present invention may further comprise one or more extracts selected from the group consisting of non-extract, beet root extract, carrot root extract and burdock root extract.

In the present invention, " Raphanus sativus var.) "is known to have an effect on indigestion, sputum and cough. The other medicinal herbs that are recorded in Donguibogam are called radish, and it is known that radish acts on menopause, circulation, promotes digestion, has a tonic effect, detoxifies and releases poison, and acts as a goddess.

In the present invention, the term " Beta vulgaris root " refers to the root portion of the beet, and the beet is also referred to as a root bran, a red bran, or a fire blanket. The main stem grows to about 1m from the southern part of Europe, and branches are divided a lot. Leaves from roots are oval or elliptical, thick and soft. Beetroot cleanse blood, is effective in anti-aging, cancer prevention, low blood pressure and liver protection.

In the present invention, " carrot ( Daucus carota var.) "is a two-year-old plant belonging to the genus Lepidoptera, and its roots are thick and straight, with yellow, navy blue, red color and cracks. Carotene contained in carrots is converted into vitamin A when absorbed into the body, which is effective in preventing and treating eye diseases such as night blindness and dry eye syndrome. In the other, carrots are classified as medicinal products that are effective for anemia, hypotension and the like.

In the present invention, " Arctium lappa L.) "is a two - year - old herbaceous plant belonging to the Asteraceae family, and its roots have been used for many years in Asia, including Korea. Mature fruit as a herb medicine is called as an ally and it is used for the purpose of fever and detoxification. Seeds and leaf parts are also used for the purpose of folk remedy or diuretic in oriental medicine. It is known that roots mainly used as food are useful for diabetes and kidney disease due to the carbohydrate mainly inulin form together with fiber, and also useful for antihypertensive and atherosclerosis as well as antioxidant and antimutagenic activity and anti-inflammatory activity have.

Root vegetables such as radish, beetroot, carrot, and burdock can contribute to immunity enhancement, antibacterial and the like, and can be included in a female cleaner composition to enhance the antibacterial effect.

In particular, the composition of the present invention can be applied to a variety of food products such as omelet extract, ginseng extract, red ginseng extract, glutinous rice extract, ginseng extract, white ginseng extract, glutinous ginseng extract, licorice extract, ginseng extract, And extracts of at least one selected from the group consisting of Angelica keiskei, Angelica keiskei, Chrysanthemum bark extract, Hwangyang extract and Hwasung extract. In the present invention, the term "herb medicine" is generically referred to as "medicinal herb" in the present invention, for example, Omija, Bongryeong, Red ginseng, Zucchinaceae, White ginseng, Gwacheonjae, Licorice, Gosam,

In the present invention, " Schizandrae Fructus ) "is a deciduous broad-leafed vine, with leaves alternating with ovate or obovate, with sharp tips, sharp teeth, and slightly hairs on the back side. The flower is reddish white, bloomed in June-July, and it is migratory. Fruit is used for food, hangs in the shape of a spike at the end of the branch, and ripens red from August to September. The main ingredients are schizandrin, schizandran, γ-schizandrin, ethamigrenal, gomisin and essential oils such as citral, nesquiqualene (), 담 (祛) function, uterine contraction, antimicrobial action, hypotensive effect (祛), 해 (祛) , Coronary action, and transaminase lowering action are known.

In the present invention, " Poria cocos " is a sclerot growing from a pine root, having a ball shape or an oval shape of 5 to 7 cm in diameter, and brown or dirty black with a piece of bark on the ground. It is said that Byeongryong is used as a stabilizer for Chiara, and it not only has the effect of stabilizing the heat, but also warms the body. It is effective for peptic ulcer, muscle cramps, thirst, dizziness, mental anxiety, and numbness. It is used for the treatment of kidney disease, cystitis, urethritis, etc. In addition, the contact dermatitis-inhibiting action effect is known.

In the present invention, the term " red ginseng " means a ginseng obtained by steaming or swelling ginseng or otherwise ginseng starch. Ginsenoside, a major ginseng saponin known as the main pharmacological component, has very different effects on saponins and other peculiar chemical structures found in other plants. Red ginseng has sedative and excitatory effects on the central nervous system. It protects the liver and acts on the endocrine system at the periphery, so that it acts indirectly on the reproductive effect, especially in anti-inflammatory and antitumor actions.

In the present invention, " Magnolia officinalis " is an evergreen broad-leaved tree belonging to the dicotyledonous plant, and is an evergreen broad-leaved tree belonging to the family Ranunculaceae, and lives in South Korea, Japan, Taiwan and southern China. As a medicinal herb, stem and egg shells have been used in the treatment of asthma and gastrointestinal disorders and contain ingredients such as magnolol, isomagnolol, honokiol, and machiol. Among them, honokiol belongs to polyphenol and is used as a useful substance showing antidepressant, thrombolytic inhibition, nerve stabilization and antibacterial activity.

In the present invention, " Puerariae radix " is a root of Pueraria lobata Ohwi according to Korean Pharmacopoeia, and is widely used as a food, beverage, and health food in the private sector. It is used for the purpose of releasing cold muscle, digestive diseases, and steel tube, and it helps the spleen and gastrointestinal muscles to rise. It is known.

In the present invention, the term " Bacillus " is a tubercle of the grown ( Bletilla striata Reichb. Fil.). The fresh raw meat contains 14.6% moisture, 30.48% starch and 1.5% glucose and contains essential oils and mucus. The roots contain bletilla mannan. Bacillus is known to be used for the treatment of complications of pulmonary tuberculosis and tuberculosis and pulmonary tuberculosis, as well as a hemostatic function for coagulating blood cells with good local hemostasis and forming an artificial thrombus

In the present invention, " Pogostemonis Herba "is widely grown in the Philippines, India and southern China. Pogostemon cabin Bentham, a perennial vegetation, is a dried plant, and contains pachouli alcohols, eugenol, cinnamic aldehyde, pagostol, pachouli pyridine, , And it is known to have a therapeutic effect on inflammatory bowel disease such as ulcerative colitis or Crohn's disease.

In the present invention, " Glycyrrhizae Radix " is a perennial herb belonging to Leguminosae, and is classified as European licorice ( Glycyrrhiza glabra L.), Manju licorice ( Glycyrrhiza uralensis F.) or other roots and leaves of the main stem (run 莖 莖) as it is or is removed. It is widely used in oriental medicine because of its excellent efficacy of pain relief and detoxification / detoxification. Sedative, anti-inflammatory and antibacterial effects.

In the present invention, " Sophora flavescens "is a perennial herb with rosemary roots and twigs. It is also known as the caterpillars of thieves, foxes, and snakes. The roots that are peeled off from the ginseng are well known as raw materials showing skin fungus inhibition, skin moisturizing, whitening, blood circulation improvement as well as preservative effect. Gosam is effective for jaundice, dysentery, dysentery, and genital itching caused by Hachohe fever (fever fever). The itch is caused by cleansing the affected part with water. It is used for skin itching, It has been known to be effective for symptoms that are sick.

In the present invention, " Eleutherococcus Senticosus ( Rupr . & Maxim. ) Maxim .) "is native to Mt. Odaesan, Mt. Jiri, Manchuria, Siberia, Hokkaido, etc. It stimulates the overall function of living organisms and promotes environmental adaptation and defense of living organisms. It is known.

In the present invention, " Persiccae Semen " is a mature seed of the peach tree Prunus persica Batsh. Belonging to the Rosaceae family. It contains fatty oil (40-50%), amygdalin, triolein, PR-A, PR-B (Shigeru et al., Shoyakugaku Zasshi 40, 2, 129, 1986) and is used for the treatment of anticoagulant blood, genomes, intestinal lubrication and stagnant blood. .

In the present invention, " Liriope Platyphylla "is a perennial plant that grows rhizomes and seeds. It is mainly distributed in low hills below 500 m in Korea, and the leaves are green throughout the year (Huh, MK, HW Huh, JS Choi, and BK Lee 2007. Genetic diversity and population structure of Liriope platyphylla (Liliaceae) in Korea. J. Life Sci. 17, 328-333.). MacMundong has been widely used in oriental medicine for curing diseases such as coughs and phlegm in Korea and China. Recently, it has been known to have an effect of treating diabetes, improving memory, inhibiting microorganisms, and suppressing inflammation.

In the present invention, " Panax ginseng " is a plant that grows in a deep mountain area, reaches a height of 60 cm, has a short rhizome, stands straight or diagonally, and develops like a bellflower root. It is widely cultivated in Korea and China. Ginseng is known to refresh the body and to help people with weakness, boredom, fatigue, anorexia, vomiting and diarrhea.

In the present invention, " Angelica gigas Nakai " is a perennial plant, which is known to be cultivated in mountainous areas and highland areas in the central part of Korea, and has been used for a long time as a medicinal material and food. Coumarin derivatives such as decursin and decursinol and α-pinene, β-eudesmol and the like as main components. It is known that the herbal medicine has an effect on the antimicrobial effect, the fatigue recovery and the blood, the anemia and the female lineage system by the pharmacological effect.

In the present invention, " Coptis chinensis ") is a perennial herb belonging to the ranuculaceae. It is known to contain alkaloid compounds such as berberine, coptisine and palmatine and components such as obacunone and obaculactone. Antimicrobial activity, blood pressure lowering effect , And relaxation of tracheal smooth muscle in the uterus

In the present invention, " Phellodendri Cortex " is a stem skin that has been peeled off from the leaves of the primrose ( Phellodendron amurense Rupr. The active ingredients of the yellowish white include peel ingredients such as berberine, palmatine, guanidine, jatrorr-hizine, phyellodendrine, candicine, menisperin alkaloid-based components such as me-nisperine, high-quality substances such as obakunone and obakulactone, and steroid-based substances. It has antimicrobial activity, blood pressure lowering effect, central nervous system inhibitory action, acetylcholine enhancing action and anti-inflammatory action, and is known to have antioxidant and anti-aging effect.

In the present invention, " Houttuynia cordata thunb.) is a prey of the Houttuynia cordata Thunb., a plant of Saururaceae, which lives in southeastern Asia and especially in Japan and Korea. It is pharmacologically known to have strong cardiac, diuretic, antibacterial, detoxifying and anti-cancer efficacy, and is used as a cosmetic and health functional food for detoxification and beauty in the private sector. It is known that there are many decanoyl acetaldehyde compounds and antioxidants, antioxidants, antifungal compounds and flavonoid compounds which are effective for diuretic, vasoconstriction and defecation.

The " extract " of the present invention is an extract obtained by extracting not only the potato, potato starch, root vegetables and / or various herbal medicines but also a mixture of the above extracts, potato, potato starch, root vegetables and / , A diluent or concentrate of the extract, a dried product obtained by drying the extract, a preparation or a purified product of the extract, or a mixture thereof, and extracts of all the formulations which can be formed using the extract itself and the extract.

The extract of the present invention can be extracted from natural, hybrid, or mutant plants of the respective plants, and can also be extracted from plant tissue cultures.

The method for extracting the extract of the present invention is not particularly limited and may be carried out according to a method commonly used in the art. Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.

The kind of the extraction solvent used in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the extraction solvent include water, anhydrous or lower alcohol of C ₁ to C ₄ , a mixed solvent of water and lower alcohol, acetone, 1,3-butylene glycol, ethyl acetate, chloroform Or a mixture of two or more of them.

More specifically, water (or distilled water) may be used as an extraction solvent in the present invention. A solvent extract may be prepared by extracting the potato, potato starch, root vegetables and / or various herbal medicines one or more times using the solvent, and the dry extract obtained by vacuum distillation or freeze-drying or spray drying the solvent extract, Can be manufactured.

In one specific embodiment of the present invention, potato extract (Example 1) and potato foil extract were prepared using water (or distilled water) (Example 2). Also, a mixture of the potato extract and the potato extract was prepared (Example 3 and Example 4), and a mixture of herbal extracts was prepared (Example 5 and Example 6).

In the present invention, the extract obtained by hot water extraction or cold extraction is filtered to remove suspended solid particles by filtration, for example, nylon or the like, or by freeze filtration, Spray drying and the like.

More specifically, the composition of the present invention is a composition containing at least one compound selected from the group consisting of sunflower seed oil, macadamia seed oil, grape seed oil, jojoba seed oil, musk rose seed oil, Viccin oil, Borage seed oil, And at least one oil selected from the group consisting of seed oil, strawberry seed oil, and drumstick seed oil.

In the present invention, " oil " contains emulsified fat and oil as a liquid at room temperature, thereby increasing emulsification activity and emulsification stability and increasing the content of free fatty acid. The oil in the present invention may be more specifically " plant seed oil ", and any plant seed or nuts oil may be included without limitation.

Sunflower seed oil is an oil extracted from sunflower seeds and contains a large amount of vitamins A and E, and is known to have good moisturizing effect and prevent skin aging.

Macadamia seed oil penetrates well into the skin and has no shine and is known to smooth the skin. Palmitoleic acid, which is abundant in macadamia seed oil, is a component that decreases in concentration in the body as it gets older and is more beneficial to older people's skin. It is also known to have a blood circulation promoting action.

Grape seed oil can be obtained by squeezing grape seeds, rich in vitamin E, an antioxidant, and contains a high concentration of linoleic acid. It has excellent moisturizing effect. It is said to have excellent cleaning effect that removes even the waste materials in the pores from the deep skin.

Jojoba seed oil can be obtained by squeezing jojoba seeds, and its chemical structure is similar to that of sebum, so it is not sticky because it penetrates well to the skin, and it is known to have skin moisturizing effect, skin wrinkle alleviation and reduction effect, have.

Musk rose seed oil can be obtained by squeezing musk rose seeds and contains tocopherol, vitamins A and B, and carotene. It is known to have effects on spots, scars, wrinkles and skin troubles.

Big sacca oil is mainly used for moisturizing purposes, and it is known that when applied to skin, pantothenic acid is increased to regenerate skin tissue and promote physiological function.

Borage seed oil can be obtained by compressing borage seed, and it is used as massage oil and makeup cream because it contains a large amount of gamma linolenic acid.

Lychee fruit oil is an oil component obtained from lychee fruit, and it is known that Lychee has an effect of menses irrigation treatment and asthma relief.

Pomegranate seed oil can be obtained by squeezing pome seeds. Pomegranate contains various nutrients such as carbohydrate, organic acid, and is known to be effective for hypertension, arteriosclerosis prevention, and women's diseases.

Coriander seed oil can be obtained by squeezing coriander seeds. Coriander seeds are used as a preservative because of their antibacterial properties, and seed oil has also been used as a fragrance.

Carrot seed oil can be obtained by squeezing carrot seeds, and is known to be effective in scar removal by promoting skin cell regeneration. In addition, it is known that carrot seeds have an insecticidal effect in an oriental herb, which is effective for eliminating intestinal parasites.

Strawberry seed oil contains essential fatty acids such as omega-3, and is rich in tocopherol and anti-aging substances, so it is known to exhibit skin soothing, moisturizing and protecting effects while maintaining skin elasticity.

Drumstick seed oil can be obtained by squeezing the drumstick seeds, has the property of retaining the fragrance, and is also used as a dye. It is known to soften the skin such as keratin and hard flesh to aid in the elimination of dead skin or to facilitate absorption of active ingredient.

These oils have been reported to have skin improving effects such as prevention of skin aging, but their use as a female cleansing agent has not been reported yet.

In Example 1 of the present invention, a mixture (Example 7) obtained by mixing plant seed oil with potato extract and a plant seed oil (Example 8) prepared by mixing potato oil extract with plant seed oil were prepared.

More specifically, the composition can be applied to a variety of plants including lavender flowers, cornflower flowers, everlasting flowers, peppermint leaves, rosemary leaves, jasmine flowers, bitter orange flowers, chamomile flowers, positional hazel flowers, orange flowers, lotus flowers, elder flowers, An aqueous solution obtained by steam distillation of one or more flowers or leaves selected from the group consisting of rose flowers, aloe vera leaves, eucalyptus leaves and sage leaves. In the present invention, " aqueous solution obtained by steam distillation of flowers or leaves " was referred to as " flower / leaf water ".

The number of flowers / leaves in the present invention can be included without limitation as needed by those skilled in the art, as long as it is an aqueous solution obtained by steam distillation of flowers or leaves of any plant other than the flowers or leaves described above.

Lavender blooms are known to help calm and revitalize the skin. Cornflower flowers are known to have skin cleansing and moisturizing effects. Everlasting water is known to have pore convergence and skin soothing effects. Peppermint leaf water is said to have the effect of cleansing pores, and rosemary leaf water is known to have skin cleansing, irritation relief and trouble-calming effects. Jasmine flowering is known to have a soothing and moisturizing effect on the skin. Veterinary orange flowering is known to have anti-aging and skin cleansing effects. Chamomile flower has been known to have skin troubles and relieves skin redness. Location Hasez flowering and orange flowering have a soothing effect on the skin. Lotus flower has antioxidant effect. Elder flower has moisturizing effect. Pine blooms have the effect of softening damaged hair. Western rose blooms have the effect of softening skin texture, and aloe vera leaf water is known to have the effect of soothing stimulated skin. Eucalyptus leaf is effective to prevent dandruff, and sage leaf water is known to have a skin cleansing effect.

The flowers / leaves are known to have skin or hair-improving effects, but their use as female cleaners has not been reported yet.

In Example 1 of the present invention, a mixture (Example 9) in which flower / leaf water was mixed with potato extract and a flower / leaf water mixture (Example 10) in potato powder extract was prepared.

More specifically, the composition of the present invention may be added to potato extract or potato peel extract

At least one extract selected from the group consisting of radish extract, beet root extract, carrot root extract and burdock root extract;

Ginseng Extract, Ginseng Extract, Ginseng Extract, Huangyu Extract, Huang Baek Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Puerariae Radix Extract, At least one extract selected from the group consisting of Rhizoma extracts;

Sunflower seed oil, macadamia seed oil, grape seed oil, jojoba seed oil, musk rose seed oil, big sae oil, borage seed oil, lychee fruit oil, pomegranate seed oil, coriander seed oil, carrot seed oil, strawberry seed oil and drum stick At least one oil selected from the group consisting of seed oils; And

Lavender flowers, cornflower flowers, everlasting flowers, peppermint leaves, rosemary leaves, jasmine flowers, bitter orange flowers, chamomile flowers, position hazel flowers, orange flowers, lotus flowers, elder flowers, An eucalyptus leaf, and a sage leaf, or an aqueous solution obtained by steam distillation of one or more flowers or leaves selected from the group consisting of sage leaves.

In one embodiment of the present invention, a potato extract, a root vegetable extract, a herbal extract, a plant seed oil and a mixture of a flower / leaf water (Example 11) and potato extract, a root vegetable extract, a complex herbal extract, (Example 12).

The potato extract or the potato peel extract, the root vegetable extract, the herbal extract, the plant seed oil and the flower / leaf water may be mixed in the same ratio on the weight basis and may be mixed in the ratio of 1: 10: 1 to 10: 1 to 10: 1 to 10 by weight.

In one embodiment of the present invention, a mixture was prepared by mixing the extracts, oils or flower / leaf water in the same ratio on the basis of the weight ratio. These mixing ratios can be modified and used as needed. In particular, the raw materials of all the extracts of the present invention are derived from natural materials and thus have no toxicity. They are classified as EWG (Environmental Working Group) grade 1 and have been proved to have excellent safety. Therefore, even if a specific extract is contained in excess, .

In the present invention, " female cleanser " is intended to prevent secretions, itching, smell, and the like, which are caused by infection by bacteria invading from the outside, and to reduce or eliminate unpleasantness. Such a cleansing agent may be effective in eliminating the causes of various women's diseases such as infertility, uterine myoma, and uterine cancer, which may be caused by cold infection, inflammation and itching as well as bacterial infection or inflammation.

The composition of the present invention can exhibit an effect of relieving the stimulation on the sensitive region while suppressing or killing harmful bacteria in the vagina.

In one specific example of the present invention, it was confirmed that the above extracts and mixtures exhibited strong growth inhibition effects (Table 1). In addition, it was confirmed that the composition of the present invention inhibits the growth of Candida bacillus and Gardnerella vaginalis, though it has no significant effect on lactobacillus casei which is a lactic acid bacterium (Table 2). In particular, the above results show that the antimicrobial effect of the composition of the present invention has little effect on the beneficial lactic acid bacteria, while the inhibitory effect on the harmful bacteria is very high and the antibacterial effect is also selectable. In addition, it was confirmed that the female cleaner composition of the present invention comprising the natural extract of the present invention was safe without toxicity to the cells of the body (Table 3).

The female cleansing composition of the present invention can be used as a cleansing agent, a pharmaceutical agent, a cosmetic agent, a wet tissue, or the like.

The detergent may be formulated into a spray, a liquid, a gel, a powder, a solid soap, a foam, or the like, but is not limited thereto. In addition, the liquid formulation can be applied to a nonwoven fabric or pulp and applied as a wet tissue.

The cosmetic composition may be a conventional lotion, a lotion, a cream, an essence, an aerosol, a powder, an oil or a mist, but is not limited thereto. In addition, in the present invention, in addition to the herbal medicine extract described above, the female cleansing composition for cosmetics may contain various components commonly used in external preparations for skin, for example, a water-soluble component, a powder component , Oil, surfactant, moisturizing agent, viscosity controlling agent, preservative, antioxidant, fragrance, pigment and the like.

The pharmaceutical preparations may be formulated into tablets, pills, powders, granules, capsules and the like as solid preparations for oral administration. Examples of the formulations for parenteral administration include creams, ointments, lotions, dressings, And the like, but the present invention is not limited thereto.

Specifically, in the above-described female cleanser composition, the potato extract or potato oil extract may contain 0.005 to 30.0% by weight based on the total weight of the cosmetic composition. And more specifically from 0.01% to 20% by weight. There is an advantage that excellent antifungal or antimicrobial effect is exhibited within the above range, and there is an advantage that the formulation of the composition is stabilized.

Further, the natural extract of the present invention can be prepared into various health functional foods by adding a palatable food ingredient and can be manufactured in a general food form, and the additive ingredient can be appropriately selected and blended by those skilled in the art have.

The potato extract or potato extract of the present invention, the composition comprising the extract, the root vegetable extract, the herbal extract, the plant seed oil and / or the mixture of flower / leaf water is excellent in antibacterial and / or antifungal activity.

In addition, since the composition of the present invention is a substance derived from natural materials, it has no toxicity and does not cause side effects even when it is applied to human body, and thus it is highly utilized as a female cleansing agent. Particularly, all the raw materials used in the present invention are classified as EWG (Environmental Working Group) grade 1, and thus it has been proved that the raw materials are excellent in safety.

It should be understood that the effects of the present invention are not limited to the effects described above, but include all effects that can be deduced from the description of the invention or the composition of the invention set forth in the claims.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are illustrative of the present invention, and the present invention is not limited by the following examples.

Example  1. Preparation of potato extract

Potato dry weight 100 g was placed in a flask and extracted with 1,000 g of extraction solvent (distilled water) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare an extract.

Example  2. Potato chips  Preparation of extract

Potato powder 100 g of dry weight was put into a flask and extracted with 1,000 g of extraction solvent (distilled water) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare an extract.

Example  3. Preparation of Potato Extract and Root Vegetable Extract Mixture

100g dry weight of radish, beetroot, carrot and burdock was put into a flask and extracted with 1,000g of extraction solvent (distilled water) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare respective extracts. Each of the above extracts was mixed in the same ratio on a weight basis and mixed with the potato extract prepared in Example 1 at a weight ratio of 5: 5 to prepare a mixture of potato extract and root vegetable extract.

Example  4. Potato chips  Preparation of a mixture of extract and root vegetable extract

100g dry weight of radish, beetroot, carrot and burdock was put into a flask and extracted with 1,000g of extraction solvent (distilled water) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare respective extracts. The mixture of the above extracts in the same ratio by weight was mixed with the potato extract prepared in Example 2 at a weight ratio of 5: 5 to prepare a mixture of potato leaf extract and root vegetable extract.

Example  5. Manufacture of mixture of potato extract and herbal extract

(100 g) of the dried weight of each of the extracts (distilled water) 1,000 (g) was added to the flask, g for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare respective extracts. Each of the extracts was mixed in the same ratio on a weight basis, and the mixture was mixed with the potato extract prepared in Example 1 at a weight ratio of 5: 5 to prepare a mixture of potato extract and complex herbal extract.

Example  6. Potato chips  Preparation of mixtures of extracts and herbal extracts

(100 g) of the dried weight of each of the extracts (distilled water) 1,000 (g) was added to the flask, g for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare respective extracts. Each of the extracts was mixed in the same ratio on a weight basis, and the mixture was mixed with the potato extract prepared in Example 2 at a weight ratio of 5: 5 to prepare a mixture of the potato extract and the herbal extract.

Example  7. Preparation of Potato Extract and Mixture of Plant Seed Oil

EWG 1 grade sunflower seed oil, macadamia seed oil, grape seed oil, jojoba seed oil, musk rose seed oil, big sae oil, borage seed oil, licorice fruit oil, pomegranate seed oil, coriander seed oil, carrot seed oil, Oil and drumstick seed oil were mixed in the same ratio on a weight basis and mixed with the potato extract prepared in Example 1 at a weight ratio of 5: 5 to prepare a mixture of potato extract and plant seed oil.

Example  8. Potato chips  Preparation of a mixture of extract and plant seed oil

EWG 1 grade sunflower seed oil, macadamia seed oil, grape seed oil, jojoba seed oil, musk rose seed oil, big sae oil, borage seed oil, licorice fruit oil, pomegranate seed oil, coriander seed oil, carrot seed oil, Oil and drumstick seed oil were mixed at the same ratio on the weight basis and mixed at a weight ratio of 5: 5 with the potato peel extract prepared in Example 2 to prepare a mixture of potato peel extract and plant seed oil.

Example  9. Potato extract and flower / Leafy  Preparation of mixture

Lavender flowers, cornflower flowers, everlasting flowers, peppermint leaves, rosemary leaves, jasmine flowers, bitter orange flowers, chamomile flowers, position hazel flowers, orange flowers, lotus flowers, elder flowers, Eucalyptus leaf and sage leaf were weighed in 100 g of dry weight in a flask and distilled at 1,000 ° C. for 1,000 to 5,000 g for 40 to 50 minutes to obtain an aqueous solution component by steam distillation method to prepare each flowering or leaf water .

The mixture of the above-mentioned blossom or leaf blend in the same ratio by weight ratio was mixed with the potato extract prepared in Example 1 at a weight ratio of 5: 5 to prepare a mixture of potato extract and flower or leaf water.

Example  10. Potato chips  Extracts and flowers / Leafy  Preparation of mixture

Lavender flowers, cornflower flowers, everlasting flowers, peppermint leaves, rosemary leaves, jasmine flowers, bitter orange flowers, chamomile flowers, position hazel flowers, orange flowers, lotus flowers, elder flowers, Eucalyptus leaf and sage leaf were weighed in 100 g of dry weight in a flask and distilled at 1,000 ° C. for 1,000 to 5,000 g for 40 to 50 minutes to obtain an aqueous solution component by steam distillation method to prepare each flowering or leaf water .

The mixture of the above flowers or leaves in the same ratio on the basis of weight ratio (referred to as flower / leaf water) was mixed with the potato extract prepared in Example 2 at a weight ratio of 5: 5 to obtain a potato extract and a flower / A mixture was prepared.

Example  11. Preparation of a mixture of potato extract, root vegetable extract, herbal extract, plant seed oil, and flower / leaf water

The mixture of the potato extract prepared in Example 1 and the root vegetable extract prepared in Examples 3 to 10, the herbal extract mixture, the plant seed oil mixture and the flower / leaf water mixture were mixed at the same ratio on the weight basis A mixture was prepared.

Example  12. Potato chips  Extracts, Root Vegetable Extracts, Herbal Extracts, Plant Seed Oil, and Flower / Leaf  Preparation of mixtures

The mixture of the potato powder extract prepared in Example 2 and the root vegetable extract prepared in Examples 3 to 10, the mixture of herbal extracts, the mixture of plant seed oil and the mixture of flower and leaf water was mixed at the same ratio A mixed mixture was prepared.

Comparative Example  1. Our own women Cleaner

A commercially available in-house cleaner was used as a comparative example.

Experimental Example  1. Evaluation of antibacterial activity

In order to confirm the antibacterial activity of the natural extracting antimicrobial composition prepared in Examples 1 and 2, a disk diffusion method was used. Candida albicans , which is a fungus, and Gardnerella , a common bacterium, vaginalis ) was used.

100 [mu] L of pre-cultured Candida albicans and guinea-nella bajinalis were dispensed into each well of Sabouraud Dextrose Agar (Difco, USA) for disk diffusion assay, and the extract was applied to a sterilized paper disk at 5 mg / And the sample was placed on the medium. Itraconazole, an antifungal agent for Candida albicans, and Ampicillin, an antibiotic for Gardnerella vaginalis were used as a positive control, and they were placed on a paper disk at a concentration of 100 μg / disk and then placed on a medium I left it. The size (mm) of the growth inhibition zone (mm) after culturing the plate medium at 28 ° C for 48 hours was measured and shown in Table 1 below.

Candida albicans Guard Nella Trousers Positive control group 27 28 Example 1 28 27 Example 2 29 27 Example 3 30 31 Example 4 32 33 Example 5 31 30 Example 6 33 32 Example 7 31 31 Example 8 32 34 Example 9 31 32 Example 10 32 31 Example 11 36 36 Example 12 37 36 Comparative Example 1 28 28

As shown in Table 1, it can be seen that Examples 1 to 12 exhibit growth inhibition effect as compared with Comparative Example 1, which is a conventional female cleaner. In particular, it was confirmed that the growth inhibition effect was remarkably superior to that of the positive control antifungal agent.

Experimental Example  2. Assessment of microbial growth inhibition

Effects of Lactobacillus casei and Lactobacillus casei on the growth of Candida albicans and Gardnerella vaginalis , which are known as lactic acid bacteria that grow in female vagina, Respectively.

Microbial growth was confirmed by increasing the turbidity in the medium and the IC ₅₀ (half maximal inhibitory concentration) value required for 50% inhibition of the antimicrobial activity and microorganisms was measured using the Broth Microdilution Susceptibility Tests Respectively.

Specifically, each strain was diluted with Sabouraud Dextrose medium to a cell density of 2 × 10 ⁵ cells / ml, and then treated by serial dilution in a 96-well plate. After incubation at 28 ° C for 24 hours, the absorbance was measured at a wavelength of 570 nm using a microplate reader (BIO-RAD) to determine IC ₅₀ values. The results are shown in Table 2 below.

sample density
(mg / ml) Survival rate (%) Lactobacillus casei Candida albicans Guard Nella Trousers Example 1 5 100 38.8 39.1 10 98 11.8 13.2 20 95 3.1 5.1 50 94 1.2 2.2 Example 2 5 100 37.8 37.7 10 97 15.1 18.3 20 96 6.1 5.5 50 92 2.1 1.5 Example 3 5 100 39.4 38.1 10 98 9.5 10.3 20 96 3.1 6.1 50 92 0.8 2.2 Example 4 5 100 27.6 28.9 10 98 14.7 15.4 20 97 5.8 3.2 50 93 1.8 2.0 Example 5 5 100 30.0 27.9 10 96 8.7 9.5 20 93 3.1 4.6 50 90 0.9 1.7 Example 6 5 100 31.2 23.4 10 97 9.6 12.5 20 95 5.8 5.3 50 90 1.3 1.0 Example 7 5 100 35.8 37.6 10 94 14.8 18.7 20 92 7.7 5.4 50 89 2.1 3.1 Example 8 5 100 33.1 35.2 10 95 14.4 18.9 20 92 6.6 5.4 50 90 2.2 2.1 Example 9 5 100 30.3 31.2 10 97 12.5 11.1 20 95 5.8 4.6 50 90 1.7 1.3 Example 10 5 100 30.1 29.8 10 98 10.3 9.3 20 96 5.1 4.9 50 92 1.5 1.2 Example 11 5 100 22.1 31.2 10 97 5.3 9.6 20 95 1.7 3.2 50 90 0.8 1.1 Example 12 5 100 23.4 30.5 10 96 5.7 9.3 20 94 3.2 4.3 50 90 1.0 1.3 Comparative Example 1 5 100 39.6 40.3 10 91 15.4 20.1 20 85 7.8 5.6 50 79 2.2 3.4

As shown in Table 2, Examples 1 to 12 of the present invention have no significant effect on lactobacillus casei, which is a lactic acid bacterium, but inhibit the growth of Candida bacillus and Gardnerella var. . In particular, in the case of Comparative Example 1, the higher the concentration, the more the growth of Lactobacillus casei was, and the growth inhibitory effect on Candida albicans and Gardnerella vaginalis was somewhat higher than that of Examples 1 to 12 And it was found that the composition of the present invention is more effective as a female cleanser than the conventional products. In addition, the above results suggest that the antimicrobial effect of the composition of the present invention is up to selectivity.

Experimental Example  3. Assessment of cytotoxicity

Experiments were conducted to confirm the cytotoxicity of the above Example 1, Example 2 and Comparative Example 1. Human Diploid Fibroblast cells were diluted to a concentration of 5000 cells / μl in a 96-well plate, and 100 μl of each was inoculated and cultured for 24 hours. After the culture, all of the medium was removed, and 90 μl of serum-free medium was added to each well. Thereafter, 10 μl of each of the samples of Examples 1 and 2 and Comparative Example 1 diluted to a final concentration of 200 μg / μl was treated in each well and cultured.

After 24 hours of incubation, 20 μl of MTT reagent dissolved in phosphate buffered saline (PBS) at a concentration of 5 mg / ml was added and incubated for 4 hours. Thereafter, the media containing the MTT reagent and the samples of Example 1, Example 2 and Comparative Example 1 were all removed, 100 μl of acidisopropanol (0.04 N HCliniso-propanol) was added to each well, stirred for 30 minutes, And the absorbance at 570 nm was measured. The cell viability of the fibroblasts was measured and the results are shown in Table 3.

Cell survival rate (%) Example 1 101.3 Example 2 100.8 Example 3 99.1 Example 4 99.4 Example 5 100.1 Example 6 101.2 Example 7 99.5 Example 8 100.8 Example 9 103.2 Example 10 101.1 Example 11 99.7 Example 12 100.3 Comparative Example 1 98.4

As shown in Table 3, it was confirmed that the female cleaner composition of the present invention comprising the natural extract of the present invention was safe and toxic to the cells of the body.

Manufacturing example 1. Bonn  Liquid women containing the inventive composition Cleaner  Composition manufacturing

A liquid female cleaner composition was prepared as shown in Table 4 below (unit: wt%).

Raw material name Content (% by weight) The composition of the present invention 20 Propylene glycol 5 1,2-hexanediol 5 Hydroxyethyl cellulose 4.25 Bp 4 Betaine 1.5 Piperazine-25-butes-26 One Phage-40-hydrogeneate One Disodium iodide 0.2 Dipotassium glycyrrhizate 0.2 Citric acid 0.2 Purified water To 100

Manufacturing example  2. Women in cream formulations containing the composition of the present invention Cleaner  Produce

A cream form cosmetic composition was prepared as shown in the following Table 5 (unit: wt%).

Composition Content (% by weight) The composition of the present invention 20 Dimethicone copolyol 10 Cyclomethicone 10 Urea 20 glycerin 20 Triethanolamine 0.02 antiseptic One Purified water To 100

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention.

Claims (9)

A potato extract or a potato peel extract. The method according to claim 1,
Wherein the composition further comprises one or more extracts selected from the group consisting of non-extract, beetroot extract, carrot extract and burdock extract. The method according to claim 1,
Ginseng Extract, Ginseng Extract, Ginseng Extract, Huangyu Extract, Huang Baek Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Puerariae Radix Extract, Wherein the composition further comprises one or more extracts selected from the group consisting of a herbal extract. The method according to claim 1,
Sunflower seed oil, macadamia seed oil, grape seed oil, jojoba seed oil, musk rose seed oil, big sae oil, borage seed oil, lychee fruit oil, pomegranate seed oil, coriander seed oil, carrot seed oil, strawberry seed oil and drum stick 0.0 > 1, < / RTI > further comprising at least one oil selected from the group consisting of vegetable oils and seed oils. The method according to claim 1,
Lavender flowers, cornflower flowers, everlasting flowers, peppermint leaves, rosemary leaves, jasmine flowers, bitter orange flowers, chamomile flowers, position hazel flowers, orange flowers, lotus flowers, elder flowers, An aqueous solution obtained by steam distillation of one or more flowers or leaves selected from the group consisting of eucalyptus leaves and sage leaves. The method according to claim 1,
At least one extract selected from the group consisting of radish extract, beet root extract, carrot root extract and burdock root extract;
Ginseng Extract, Ginseng Extract, Ginseng Extract, Huangyu Extract, Huang Baek Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Ginseng Extract, Puerariae Radix Extract, At least one extract selected from the group consisting of Rhizoma extracts;
Sunflower seed oil, macadamia seed oil, grape seed oil, jojoba seed oil, musk rose seed oil, big sae oil, borage seed oil, lychee fruit oil, pomegranate seed oil, coriander seed oil, carrot seed oil, strawberry seed oil and drum stick At least one oil selected from the group consisting of seed oils; And
Lavender flowers, cornflower flowers, everlasting flowers, peppermint leaves, rosemary leaves, jasmine flowers, bitter orange flowers, chamomile flowers, position hazel flowers, orange flowers, lotus flowers, elder flowers, An aqueous solution obtained by steam distillation of one or more flowers or leaves selected from the group consisting of eucalyptus leaves and sage leaves. 7. The composition according to any one of claims 1 to 6, wherein the composition exhibits an antifungal effect against Candida albicans or an antimicrobial effect against Gardnerella vaginalis . Cleaner composition. The method according to claim 1,
Wherein the extract is selected from the group consisting of water, an anhydrous or lower alcohol of C ₁ to C ₄ , a mixed solvent of water and a lower alcohol, acetone, 1,3-butylene glycol, ethyl acetate and chloroform Gt; The method according to claim 1,
Wherein the potato extract or potato oil extract is contained in an amount of 0.005 to 30.0% by weight based on the total weight of the cosmetic composition.