CN112315860A

CN112315860A - Chinese herbal medicine system infant hip-protecting cream and preparation method thereof

Info

Publication number: CN112315860A
Application number: CN202011127148.3A
Authority: CN
Inventors: 李建全; 周蕾; 苏隆腾; 杨鑫权; 石婷婷
Original assignee: Shenzhen PurCotton Technology Co Ltd
Current assignee: Shenzhen PurCotton Technology Co Ltd
Priority date: 2020-10-20
Filing date: 2020-10-20
Publication date: 2021-02-05

Abstract

The invention discloses a Chinese herbal medicine system infant hip-protecting cream which comprises the following components in parts by weight: 10-50 parts of a skin conditioner, 0.1-10 parts of a Chinese herbal medicine antibacterial preservative, 5-30 parts of grease, 5-30 parts of a supplementary aid, 0-5 parts of an aromatic and 10-80 parts of water; the Chinese herbal medicine antibacterial preservative comprises a peony extract and a scutellaria extract. The Chinese herbal medicine system infant hip-protecting cream product disclosed by the invention is warm, moist, nourishing, strong in antibacterial action, unchanged in effect stability, free of stimulation to human skin and free of toxic and side effects; by using the Chinese herbal medicine antiseptic system, the Chinese herbal medicine components in the hip-protecting cream serve as the antiseptic system, and the hip-protecting cream is moist, non-greasy, good in texture, easy to smear and absorb, mild, fresh and cool, moistens and cares delicate skin of infants, and avoids red hips.

Description

Chinese herbal medicine system infant hip-protecting cream and preparation method thereof

Technical Field

The invention relates to the field of skin care, in particular to a Chinese herbal medicine system infant hip-protecting cream and a preparation method thereof.

Background

Diaper rash, also known as diaper rash, refers to redness of the skin at the diaper site of a newborn, such as around the anus, buttocks, thighs, perineum, etc., with scattered maculopapules or herpes. The main inducement is that the baby diaper is not changed frequently or washed cleanly, and the skin of the baby is contacted and irritated for a long time; or the diaper is hard and is caused by local friction; and exacerbation following a secondary bacterial or candida infection.

However, the protective layer of the infant's skin has not yet developed completely and thus the external stimuli are more easily penetrated. In particular, the infant skin has not developed a defense against certain bacteria, is more susceptible to infection, and has not developed an immune system that is sufficiently effective against infection. Infants also have a weaker ability to sweat, which reduces their ability to regulate body temperature through sweating, which may lead to diaper rash. The fat content of the skin of infants is higher, which makes fat-soluble substances (which may be irritants) more likely to penetrate the skin. Therefore, the autoimmune function of the newborn is not perfect, the skin is easy to be stimulated by the outside to generate a series of skin inflammatory reactions, and diaper dermatitis eczema belongs to common skin inflammatory pathological changes of the infants. Causes of occurrence generally include: when wet diapers are used, diapers which are not cleaned by washing products such as soap and the like are not replaced timely, and the like, the skin of the baby is very delicate and is easy to be stimulated by external stimulation to generate irritation reaction, and symptoms such as pruritus, redness and the like appear.

Most of the products on the market today use cosmetic preservative systems, which achieve preservative function by using quasi-industrial preservatives, such as imidazolidinyl urea, bis (hydroxymethyl) imidazolidinyl urea, benzalkonium chloride, phenoxyethanol, etc. Although the skin-care preservative belongs to the approved preservatives in the technical Specification for cosmetic safety, the skin-care preservative still has harm to the skin, and particularly the skin of infants is more fragile and seriously even aggravates the symptoms of skin inflammation, red rash, pruritus and the like.

The Chinese herbal medicine generally has the characteristics of mild effect, small irritation and high safety, is ideal when being used as a preservative, and has the advantages of lasting and stable effect, mild effect, wide application range, no side effect or small side effect, so the research and development of the Chinese herbal medicine become the latest trend of complying with the concept of returning to nature, scientific cosmetology and scientific nursing. In the application practice of external application and oral administration for thousands of years, a lot of drug effect records and experiences are accumulated in the traditional Chinese herbal medicine in China, and the dosage, safety and side effects of the traditional Chinese herbal medicine are verified. In particular, when these cosmetics are used for infants, various problems occur, such as high irritation, unsatisfactory use effect, and the like.

Besides the need of avoiding some adverse effects, the actual using effect of the infant hip-care cream needs to be further improved, for example, the infant hip-care cream has strong antibacterial effect, stable effect, no stimulation to the skin of infants, no toxic or side effect and radically avoids the problem of skin inflammation.

Disclosure of Invention

In view of the problems in the prior art, one of the objectives of the present invention is to provide a herbal ointment for protecting the buttocks of infants.

The invention also aims to provide a preparation method of the Chinese herbal medicine system infant hip-protecting cream.

Further, the invention also aims to provide a using method of the Chinese herbal medicine system infant hip-protecting cream.

The invention adopts the following technical scheme:

as a specific embodiment, the Chinese herbal medicine system infant hip-care cream comprises the following components in parts by weight:

the Chinese herbal medicine antibacterial preservative comprises a peony extract and a scutellaria extract.

Further, as a preferred embodiment, the Chinese herbal medicine system infant hip-care cream comprises the following components:

the term "Chinese herbal medicine" as used herein has the meaning conventionally understood in the field of traditional Chinese medicine, and Chinese herbal medicine is mainly composed of botanical herbs (roots, stems, leaves, fruits) and the like. And the preparation process also has the method or means which is conventionally used in the field of traditional Chinese medicine, such as cutting, air drying, sun drying, baking, grinding, extracting and the like.

Further, the Chinese herbal medicine antibacterial preservative accounts for 0.1-10 parts (based on the weight of the Chinese herbal medicine system infant hip care cream), such as 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1,2, 3, 4, 5, 6, 7, 8, 9 or 10 parts.

As a preferred exemplary embodiment, the Chinese herbal medicine antibacterial preservative comprises the following components in a weight ratio of 0.5-2: 1 peony extract and scutellaria extract. For example, the Chinese herbal medicine antibacterial preservative is prepared from the following components in parts by weight: 3 peony extract and scutellaria extract. Optionally, the Chinese herbal medicine antibacterial preservative is prepared from the following raw materials in a weight ratio of 1: 1 peony extract and scutellaria extract. Optionally, the Chinese herbal medicine antibacterial preservative is prepared from the following raw materials in a weight ratio of 1.5: 1 peony extract and scutellaria extract.

Specifically, the peony extract is prepared by washing moutan cortex radicis and/or moutan radicis, grinding and pulverizing (for example, grinding and pulverizing to 800-1200 mesh, preferably 1000 mesh), extracting by steaming, filtering at 1000-1500 mesh, preferably 1200 mesh, purifying, and drying.

The term "peony extract" as used herein is also known as root bark of peony, root bark of moutan, root bark of Salvia miltiorrhiza. The peony (bark) extract is also called paeonol. In the application, paeonol is used for treating symptoms such as acute skin eczema, pruritus and the like, and has obvious curative effect.

Specifically, the scutellaria baicalensis extract is prepared by washing scutellaria baicalensis, grinding and pulverizing (for example, grinding and pulverizing to 800-1200 mesh, preferably 1000 mesh), extracting by boiling, then filtering at 1000-1500 mesh, preferably 1200 mesh, purifying, and drying.

The term "scutellaria" as used herein, also known as camellia root or camellia japonica root, is a perennial herb of the genus scutellaria of the family labiatae.

Baicalin (Baicalin) is a flavonoid compound extracted and separated from scutellaria baicalensis (root), has obvious biological activity, has the effects of bacteriostasis, diuresis, anti-inflammation, allergy resistance and spasmolysis, has strong physiological effects of anticancer reaction and the like, and plays an important role in clinical medicine. Baicalin can absorb ultraviolet rays, remove oxygen free radicals and inhibit the generation of melanin, so that the baicalin can be used for medicines and cosmetics and is a good raw material for functional cosmetic.

Further, the skin conditioning agent comprises 10-50 parts (based on the weight of the herbal system infant hip care cream), such as 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50 parts.

Further, the skin conditioner comprises at least one of camellia seed oil, gossypium herbaceum seed extract, tocopheryl acetate, bisabolol (or alpha-bisabolol), macadamia ternifolia seed oil, olive fruit extract, calendula extract, panthenol, and glycerin.

The INCI (i.e., the International Chinese name catalog for cosmetic raw materials standards) of the term "Camellia JAPONICA (Camellia JAPONICA SEED OIL" as used herein is named "Camellia JAPONICA SEED OIL". The source may be commercially available, for example from the company Leternal Nature Shanghai Boshu industries, ITEM CODE: HT 1128. Camellia JAPONICA (Camellia JAPONICA) seed oil is obtained from Camellia JAPONICA seed, contains fatty acid, camellin, tea polyphenols, saponin, tannin, and is rich in antioxidant, squalene and flavonoid with antiinflammatory effect. The camellia seed oil is also rich in vitamin E and trace elements such as calcium, iron, zinc and the like, wherein the types of amino acids contained in the camellia seed oil are the most abundant in all edible oils, and the camellia seed oil also contains tea polyphenol and camellin (namely tea saponin) which are specific physiological active substances not contained in olive oil. Optionally, the camellia oil comprises 5-10 parts (based on the weight of the skin conditioner or the weight of the herbal system infant hip care cream), such as 5, 6, 7, 8, 9 or 10 parts.

As used herein, the INCI (catalog of International cosmetic raw materials for Chinese nomenclature) for "Gossypium HERBACEUM SEED extract" is called "Gossypium HERBACEUM SEED OIL", which is called "natural hydrogenated OIL", which is rich in high quality vitamins, fatty acids and sterols, which are combined in perfect proportions and complement each other to achieve unique skin care properties of COTTON OIL. The molecules of the fermented cottonseed oil are smaller and are easier to be absorbed by skin; after fermentation, the absorption rate of the cottonseed oil by a human body is higher. The source may be commercially available, for example from the company Literna Nature Shanghai Boshu industries, ITEM CODE: S10090. Optionally, the gossypium herbaceum seed extract is present in an amount of 8-14 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 8, 9, 10, 11, 12, 13, or 14 parts.

Further, the grass cotton seed extract comprises 1-3 wt% of alanine, 3-6 wt% of arginine, 1.5-5.5 wt% of aspartic acid, 0.1-1.5 wt% of cystine, 7-10 wt% of glutamic acid, 1-3.5 wt% of glycine, 0.5-3 wt% of histidine, 0.5-3 wt% of isoleucine, 1.5-4 wt% of leucine, 0.5-3 wt% of lysine, 0.1-3 wt% of methionine, 1-4 wt% of phenylalanine, 1-3 wt% of proline, 1-3 wt% of serine, 0.5-3 wt% of threonine, 0.1-2 wt% of tryptophan, 0.1-3 wt% of tyrosine, and 0.5-3 wt% of valine based on the weight of the grass cotton seed extract.

As an exemplary embodiment, the grass cotton seed extract comprises 1.81 wt% alanine, 4.4 wt% arginine, 4.02 wt% aspartic acid, 0.64 wt% cystine, 8.47 wt% glutamic acid, 1.83 wt% glycine, 1.45 wt% histidine, 1.27 wt% isoleucine, 2.55 wt% leucine, 1.57 wt% lysine, 0.70 wt% methionine, 2.23 wt% phenylalanine, 1.62 wt% proline, 2.04 wt% serine, 1.52 wt% threonine, 0.51 wt% tryptophan, 0.98 wt% tyrosine, 1.80 wt% valine, based on the weight of the grass cotton seed extract.

Optionally, the tocopheryl acetate is present in an amount of 0.5-2 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system baby hip care cream), such as 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2 parts.

Optionally, the bisabolol comprises 0.5-1.5 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, or 1.5 parts.

The INCI (i.e., International catalog of Chinese names for Standard cosmetic raw materials) name for the term "macadamia Persica (MACADAMIA INTEGRIFOLIA) seed oil" as used herein is "MACADAMIA INTEGRIFOLIASEED OIL". The source may be commercially available, for example from the company Leternal Nature Shanghai Boshu industries, Inc. Optionally, the macadamia whole-edge nut seed oil comprises 4-10 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 4, 5, 6, 7, 8, 9, or 10 parts.

The term "olive fruit extract" as used herein is mainly derived from the leaves of olive trees, the main component of the extract is oleuropein, the source of which may be commercially available. The olive fruit extract can relieve discomfort caused by insufficient arterial vascular flow, including angina pectoris and vascular intermittent claudication. It helps to eliminate atrial fibrillation (arrhythmia), lower hypertension and inhibit oxidation to produce LDL cholesterol. Optionally, the olive fruit extract comprises 5-10 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 5, 6, 7, 8, 9, or 10 parts.

As used herein, the INCI (i.e., the International Chinese nomenclature catalogue for cosmetic raw materials standards) name of the term "marigold (Calendilla OFFICINALIS) flower extract" is "Calendilla OFFICINALIS flower extract". The source may be purchased commercially. Optionally, the calendula (calendula officinalis) flower extract is present in an amount of 0.1-1 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1 part.

The term "panthenol" as used herein, also known as panthenol, is a vitamin B5 derivative, commonly referred to as "previtamin B5". Optionally, the panthenol is present in 0.1-1 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1 part.

Optionally, the glycerin comprises 8-14 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), such as 8, 9, 10, 11, 12, 13, or 14 parts.

Further, the herbal antiseptic further comprises at least one of phellodendron extract, achyranthes extract, polygonum cuspidatum extract, rheum officinale extract, radix paeoniae alba extract, mint extract and oldenlandia diffusa extract, and the amount of the herbal antiseptic can be 10-30 parts, or 10-20 parts, or 20-30 parts (based on the weight of the skin conditioner, or based on the weight of the herbal system infant hip care cream), as a non-limiting example.

Further, the oil and fat accounts for 5-30 parts (based on the weight of the Chinese herbal medicine system infant hip care cream), such as 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 parts.

Further, the grease (or a substance having grease properties) includes at least one of petrolatum, liquid paraffin, microcrystalline wax, gluconolactone, dioctyl carbonate, coconut oil, palm oil, mango seed fat, cacao seed fat, beeswax, and lanolin. Optionally, the grease (or substance having grease properties) comprises petrolatum, liquid paraffin, microcrystalline wax, gluconolactone, and dioctyl carbonate.

By way of non-limiting example, petrolatum may be used in amounts of 3-8 parts (based on the weight of the oil, or based on the weight of the herbal system infant hip care cream), such as 3, 4, 5, 6, 7 or 8 parts.

As a non-limiting example, the liquid paraffin may be used in an amount of 1 to 5 parts (based on the weight of the grease, or based on the weight of the herbal system infant hip care cream), for example, 1,2, 3, 4, or 5 parts.

By way of non-limiting example, the liquid microcrystalline wax may be used in an amount of 1-5 parts (based on the weight of the oil or fat, or based on the weight of the herbal system infant hip care cream), such as 1,2, 3, 4, or 5 parts.

By way of non-limiting example, the amount of liquid gluconolactone may be 1-2 parts (based on the weight of the oil or fat, or based on the weight of the herbal system infant hip care cream), such as 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or 2.

As a non-limiting example, the amount of liquid dioctyl carbonate may be 1-2 parts (based on the weight of the grease, or based on the weight of the herbal system infant hip care cream), such as 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or 2.

Further, the supplementary aid includes at least one of zinc oxide, propylene glycol (e.g., 1, 3-propanediol), butylene glycol, pentylene glycol (e.g., 1, 2-pentanediol), hexylene glycol (e.g., 1, 2-hexanediol), heptanediol, octanediol (e.g., 1, 2-octanediol). Optionally, the supplemental aid comprises zinc oxide and hexylene glycol.

By way of non-limiting example, zinc oxide may be used in an amount of 7 to 15 parts (based on the weight of the supplemental aid, or based on the weight of the herbal system infant hip care cream), such as 7, 8, 9, 10, 11, 12, 13, 14, or 15 parts. The zinc oxide has the effects of deodorizing, resisting bacteria, astringing, protecting and improving the health condition of skin after being used together with other components.

By way of non-limiting example, hexylene glycol may be used in an amount of 3 to 8 parts (based on the weight of the supplemental aid, or based on the weight of the herbal system infant hip care cream), such as 3, 4, 5, 6, 7, or 8 parts. The hexanediol in the application has the effects of dissolving and preserving after being used together with other components, can ensure that the texture of the skin care product is lighter and thinner, is easier to smear and push away when in use, and can preserve corrosion to avoid the components from going bad or rotten. Propylene glycol, butylene glycol, pentylene glycol, heptylene glycol, octylene glycol may be interchanged with and/or used with hexylene glycol.

Further, the aromatic agent is 0-5 parts (based on the weight of the Chinese herbal medicine system infant hip care cream), such as 0, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4 or 5 parts.

Further, the aromatic comprises at least one of lemon fruit oil, sweet orange fruit oil, tangerine fruit oil and grapefruit fruit oil. Optionally, the aromatic is lemon fruit oil or bergamot (Citrus aurantium bergamia) fruit oil. In particular, the fragrance is not a perfume commonly understood in the art, such as a chemical perfume, an artificial perfume. As an example, the fragrance is a natural fruit oil and/or a natural essential oil.

As used herein, the INCI (i.e., International catalog of names in Standard for cosmetic raw materials, Chinese) name of "Citrus AURANTIUM Bergamia (BERGAMOT) FRUIT OIL" of the term "Citrus AURANTIUM Bergamia (Citrus AURANTIUM BERGAMIA) FRUIT OIL" is "Citrus AURANTIUM Bergamia (Citrus BERGAMOT) FRUIT OIL".

Further, the water accounts for 10-80 parts (based on the weight of the Chinese herbal medicine system infant hip care cream), such as 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 70 or 80 parts.

As a preferred exemplary embodiment, the herbal system infant hip care cream is free of non-herbal preservatives including phenoxyethanol, dichlorobenzyl alcohol, phenoxyisopropanol, benzalkonium chloride, imidazolidinyl urea, bis (hydroxymethyl) imidazolidinyl urea, benzyl alcohol, benzoic acid, salicylic acid, boric acid, sorbic acid, potassium sorbate, sodium benzoate, chlorphenesin, methylchloroisothiazolinone, methylisothiazolinone.

Furthermore, the Chinese herbal medicine system infant hip-protecting cream does not contain or contain dioxane, sodium dodecyl sulfate, sodium dodecyl polyoxyethylene ether sulfate, sodium trideceth sulfate, ammonium dodecyl polyoxyethylene ether sulfate, styrene-acrylamide copolymer and the like.

Further, the preparation method of the Chinese herbal medicine system infant hip-protecting cream comprises the following steps: mixing the components according to the proportion.

Specifically, as a non-limiting embodiment, a portion of the fat and a portion of the supplemental aid are mixed and heated to 70 ℃ to 90 ℃, preferably 80 ℃ to 85 ℃, to be completely melted;

adding part of skin conditioner and the rest oil into the melted mixed oil, stirring and mixing, and keeping the temperature to obtain an oil phase;

dissolving the remaining skin conditioning agent, the herbal antimicrobial preservative, and the remaining supplementary adjuvant in water, placing in another container, and heating to 75-85 deg.C (such as 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, or 85 deg.C) to obtain water phase;

adding the oil phase into the water phase under stirring, and grinding to emulsify;

optionally, adding aromatic (fruit oil) when the temperature is reduced to 40-60 deg.C (such as 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60 deg.C, preferably 50 deg.C), grinding thoroughly until emulsification is complete, and cooling to room temperature to obtain the hip-protecting cream.

The raw materials used in the present invention may be generally commercially available or may be prepared according to the operating specifications in the industry unless otherwise specified.

As an example, the use method of the Chinese herbal medicine system infant hip-protecting cream comprises the following steps: the infant hip-protecting cream is applied to the external body parts of an infant, such as the buttocks and the legs, or other parts (such as the face, the chest, the back, the arms and the like), and is lightly applied and massaged, so that the infant hip-protecting cream in a Chinese herbal medicine system is absorbed by the skin of the infant.

As used herein, "and/or" includes any and all combinations of one or more of the associated listed items. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.

Unless defined otherwise, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

The exemplary invention described herein may suitably lack any one or more of the element limitations, which are not specifically disclosed herein. Thus, the terms "comprising," "including," "containing," and the like are to be construed broadly and in a non-limiting sense. Furthermore, the terms used herein are used as terms of description and not of limitation, and there is no intention in the use of such terms to describe only some of their characteristics but, in the light of the claims, various modifications are possible within the scope of the invention. Thus, while the present invention has been particularly disclosed in terms of preferred embodiments and optional features, modification of the invention herein disclosed to embody it may be noted by those skilled in the art, and such modifications and variations are considered to be within the scope of the invention.

Compared with the prior art, the invention has the beneficial effects that:

(1) the Chinese herbal medicine system infant hip-protecting cream provided by the invention extracts high-purity plant extracts, so that the product is warm, moist and nourishing, strong in antibacterial action, unchanged in effect stability, free of stimulation to human skin and free of toxic and side effects;

(2) the infant hip care cream adopts a Chinese herbal medicine antiseptic system, Chinese herbal medicine components serve as the antiseptic system in the hip care cream, and the problem of skin inflammation is radically solved;

(3) the Chinese herbal medicine system infant hip-protecting cream is particularly suitable for tender skin of infants, is moist, non-greasy, good in texture, easy to smear and absorb, mild and fresh, moistens and protects tender skin of infants, and avoids 'red butt'.

Detailed Description

For better explanation of the present invention, the following specific examples are further illustrated, but the present invention is not limited to the specific examples.

Example 1

The Chinese herbal medicine system infant hip-protecting cream is prepared from the following components in parts by weight:

mixing petrolatum, liquid paraffin, zinc oxide, microcrystalline wax and gluconolactone, and heating to 80-85 ℃ to melt the mixture completely;

adding tocopherol acetate, bisabolol, camellia seed oil, dioctyl carbonate, macadamia ternifolia seed oil and panthenol into the melted mixed grease, stirring and mixing, and keeping the temperature to obtain an oil phase;

dissolving semen gossypii extract, cortex moutan/root extract, Scutellariae radix extract, fructus Oleae Europaeae extract, herba Sidae Rhombifoliae extract, glycerol, and hexanediol in deionized water, placing in another container, and heating to 80 deg.C to obtain water phase;

slowly adding the oil phase into the water phase under continuous stirring, and grinding to emulsify the oil phase;

and when the temperature is reduced to 50 ℃, adding bergamot fruit oil, fully grinding until complete emulsification, and cooling to room temperature to obtain the hip-protecting ointment.

Example 2

the procedure was similar to example 1.

Example 3

the procedure was similar to example 1.

Comparative example 1

The hip-protecting cream is prepared from the following components in parts by weight:

the hip-care cream of comparative example 1 does not contain the moutan bark/root extract and the scutellaria baicalensis extract, and the remaining components are the same as those of the infant hip-care cream of the Chinese herbal medicine system of example 1.

Comparative example 2

the hip-care cream of comparative example 2 did not contain the gossypium herbaceum seed extract, moutan bark/root extract, and scutellaria baicalensis extract, and the remaining ingredients were the same as those of the infant hip-care cream of the chinese herbal medicine system of example 1.

And (3) evaluating the product effect:

experiment one: heavy metal and microorganism detection assay

Detecting items: lead, mercury, arsenic, total number of colonies, total number of molds and yeasts, faecal coliform, staphylococcus aureus, pseudomonas aeruginosa.

The detection basis is as follows: QB/T1857-

The results are shown in table 1: the detected items conform to the specification of QB/T1857-2013 standard.

Table 1: test results of hip-pads in examples 1 to 3

Experiment two: skin irritation/Corrosion test (multiple skin irritation test)

Skin-friendly stimulation experiments were performed on the hip-pads of examples 1 to 3 and comparative examples 1 to 2, and 4 rabbits were selected for each experimental example. Laboratory temperature: 20-24 ℃, relative humidity: 60 to 70 percent. Approximately 24h prior to the trial, animals were clipped to remove hair from both sides of the spine in the back to a range of 2 x 3 cm. The application area was 2.5 x 2.5 cm. Applying about 0.5ml of hip-protecting ointment on one side of skin, and applying solvent on the other side of the skin as control when the test object is prepared with non-irritant solvent for 1 time per day for 14 days. From the next day, the hair should be cut and the residual test substance removed with water or a non-irritating solvent before each application. The results were observed after one hour and were scored for irritation response as specified in the cosmetic hygiene code (2007 edition), and the results of the skin acute irritation test are shown in table 2:

the test result shows that the hip-protecting cream has mild property, and the skin irritation test result shows that the hip-protecting cream has no acute skin irritation.

Experiment three, efficacy experiment:

test objects: in order to meet the diagnosis standard of diaper dermatitis of infants, the skin of a mild infant patient is not damaged, flaky erythema can be seen on the covered parts of the diaper, such as perineum, scrotum, inner thigh, buttocks and the like, the flaky erythema is matched with the covered area of the diaper, and the edge is clear. Infants between 0 and 3 years of age, male and female are not limited, no moisturizers, antihistamines, and topical glucocorticoids were used in the lesion area one month prior to the study, and the subject's guardian must ensure that various other products, hip pads, glucocorticoid ointments, etc., must not be used in the lesion area during the 24 hour period prior to assessment.

The experimental steps are as follows: the number of completed cases was 28, and example 1 containing the antibacterial preservative ingredient of the Chinese herbal medicines and comparative examples 1 and 2 not contained were compared.

Before the hip protection cream is coated, the part needing to be coated is washed clean by warm water and is lightly wiped dry by soft cloth, the hip protection cream is coated on an affected part, the thickness of the hip protection cream is about 0.5-1mm, the hip protection cream is coated twice every day, and the hip protection cream is observed on the first day, the second day, the third day, the fourth day, the fifth day, the sixth day and the seventh day respectively, the red hip disappears as the cure time during the observation period, the time is recorded as the red hip disappearance days, and the corresponding accumulated cure case number and the corresponding time are recorded by analogy.

The experimental results are as follows: cumulative number of red hip loss cases-time statistics are given in table 3 below:

and (4) experimental conclusion: the hip-protecting cream product can promote the recovery of mild red hips and has better effect on the mild red hips. In addition, the herbal system infant hip cream of example 1 (examples 2 to 3 have similar effects to example 1) can be absorbed and repaired more quickly. In addition, the gossypium herbaceum seed extract in the formula of the invention is compatible with other components, especially the peony extract and the scutellaria baicalensis extract, so that the effect of healing red buttocks can be synergistically increased.

In addition, according to the cosmetic stability test which is commonly used in the industry, the long-term stability of the product of the invention, such as a high and low temperature storage stability test, a viscosity regulation test, a packaging stability test, a color stability test and the like, is tested, and the detection result of the product of the invention is qualified.

The above description is only exemplary of the present invention and is not intended to limit the scope of the present invention, which is defined by the claims appended hereto, as well as the appended claims.

Claims

1. The Chinese herbal medicine system infant hip-protecting cream is characterized by comprising the following components in parts by weight:

2. The herbal system infant hip care cream of claim 1, comprising the following components:

3. the herbal system infant hip care cream of claim 1, wherein the skin conditioning agent comprises at least one of camellia seed oil, gossypium herbaceum seed extract, tocopheryl acetate, bisabolol, macadamia ternifolia seed oil, olea europaea fruit extract, calendula officinalis extract, panthenol, and glycerin.

4. The herbal system infant hip care cream of claim 1, wherein the herbal antimicrobial preservative further comprises at least one of an extract of phellodendron amurense, an extract of achyranthes bidentata, an extract of polygonum cuspidatum, an extract of rheum officinale, an extract of paeonia lactiflora pall, an extract of mentha haplocalyx, and an extract of oldenlandia diffusa.

5. The herbal system infant hip care cream of claim 1, wherein the oil comprises at least one of petrolatum, liquid paraffin, microcrystalline wax, gluconolactone, dioctyl carbonate, coconut oil, palm oil, mango seed butter, cocoa seed butter, beeswax, and lanolin.

6. The herbal system infant hip care cream of claim 1, wherein the supplementary aid comprises at least one of zinc oxide, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, heptylene glycol, and octylene glycol.

7. The herbal system infant hip care cream according to claim 1, wherein the herbal antibacterial preservative comprises the following components in a weight ratio of 0.5-2: 1 peony extract and scutellaria extract.

8. The herbal system infant hip care cream of claim 1, wherein the herbal system infant hip care cream is free of non-herbal preservatives including phenoxyethanol, dichlorobenzyl alcohol, phenoxyisopropanol, benzalkonium chloride, imidazolidinyl urea, bis (hydroxymethyl) imidazolidinyl urea, benzyl alcohol, benzoic acid, salicylic acid, boric acid, sorbic acid, potassium sorbate, sodium benzoate, chlorphenesin, methylchloroisothiazolinone, methylisothiazolinone.

9. The herbal system infant hip care cream of claim 1, wherein the fragrance comprises at least one of lemon fruit oil, sweet orange fruit oil, tangerine fruit oil, grapefruit fruit oil.

10. The method of preparing a herbal system infant hip care cream according to any one of claims 1 to 9, comprising the steps of: mixing the components according to the proportion.