CN111265437A

CN111265437A - Multi-effect repair oil for infants and children and preparation method thereof

Info

Publication number: CN111265437A
Application number: CN202010280161.6A
Authority: CN
Inventors: 丘北泳; 麦康; 黄友艳
Original assignee: Zhongshan Carefor Daily Necessities Co ltd
Current assignee: Zhongshan Carefor Daily Necessities Co ltd
Priority date: 2020-04-10
Filing date: 2020-04-10
Publication date: 2020-06-12

Abstract

The invention relates to multi-effect repair oil and a preparation method thereof, belonging to the field of daily skin care products. A multi-effect repair oil for infants and children and a preparation method thereof comprise 30-50 wt% of caprylic/capric triglyceride, 0.02-0.2 wt% of oryzanol, 0.2-2 wt% of phytosterol low erucic acid rapeseed oil glyceride, 15-25 wt% of ethylhexyl palmitate, 0.02-0.2 wt% of bisabolol, 0.1-1 wt% of tocopherol acetate, 5-15 wt% of jades oil, 5-15 wt% of beneficial oil and 10-30% of cyclomethicone. The invention utilizes the base oil (caprylic/capric triglyceride, ethylhexyl palmitate) to form a layer of oil film on the surface of the skin, the effective substances are dissolved in the base oil, and the effective substances dissolved in the oil film can be slowly released to act on the skin, thereby not only being capable of isolating harmful substances for a long time, but also being capable of soothing and repairing the skin for a long time.

Description

Multi-effect repair oil for infants and children and preparation method thereof

Technical Field

The invention relates to a skin care product, in particular to multi-effect repair oil for infants and children and a preparation method thereof.

Background

The skin thickness of the baby is only 0.1 times of that of the adult skin, and the baby is easily abraded due to the roughness of the diaper and towel contacted with the baby during the growth process; or excessive washing or washing modes are not suitable for the infant with large activity, which causes diaper rash and red buttocks/facial eggs. In severe cases, external bacteria invasion causes skin inflammation, aggravates skin rash and chap of infants in a vicious circle, and even causes ulcer and bedsore. And spread to the inner sides of thighs, groin and neck, thus seriously affecting the health of the baby.

The main skin care oil products for babies and children in the market mainly take olive oil, camellia seed oil and synthetic oil as main body oil, the products mainly play a role in moisturizing and nourishing skin, and mainly play a role in physically isolating urine by an oil film on the skin care buttocks, the products take vegetable oil as an effective component, the effect is single, the action mechanism is simple, the products are more preventive, and the soothing effect corresponding to the red buttocks or red face eggs is general.

Therefore, it is very necessary to develop a special skin care product for preventing skin rash and chap of infants.

Disclosure of Invention

The invention aims to solve the technical problem of providing multi-effect repair oil for infants and children and a preparation method thereof, and solves the problems that the existing skin care products for infants cannot effectively isolate harmful substances for a long time and slowly repair the skin of infants for a long time.

Technical scheme

A multi-effect repair oil for infants and children is characterized in that: 30-50 wt% of caprylic/capric triglyceride, 0.02-0.2 wt% of oryzanol, 0.2-2 wt% of phytosterol and low erucic acid rapeseed glyceride, 15-25 wt% of ethylhexyl palmitate, 0.02-0.2 wt% of bisabolol, 0.1-1 wt% of tocopheryl acetate, 5-15 wt% of lily jade screen oil, 5-15 wt% of beneficial oil and the balance of cyclopolydimethylsiloxane.

Further, the preferable mass percentages of the components are as follows: 35-45 wt% of caprylic/capric triglyceride, 0.05-0.15 wt% of oryzanol, 0.5-2 wt% of phytosterol and low erucic acid rapeseed glyceride, 18-24 wt% of ethylhexyl palmitate, 0.05-0.2 wt% of bisabolol, 0.3-0.8 wt% of tocopheryl acetate, 5-15 wt% of lily jade screen oil, 5-15 wt% of beneficial oil and the balance of cyclomethicone.

Further, the further preferred mass percentage of each component is as follows: 38-42% of caprylic/capric triglyceride, 0.08-0.12% of oryzanol, 0.8-1.5% of phytosterol low erucic acid rapeseed glyceride, 20-22% of ethylhexyl palmitate, 0.08-0.12% of bisabolol, 0.4-0.6% of tocopheryl acetate, 8-12% of lily jade screen oil, 8-12% of beneficial oil and the balance of cyclomethicone.

Further, the Baihuayu screen oil component comprises: caprylic/capric triglyceride, sunflower seed oil, safflower extract, gardenia extract, chrysanthemum extract, plum blossom extract, butylated hydroxytoluene.

A method of preparing a multi-effect rejuvenating oil for infants and children, comprising the steps of:

(1) adding oryzanol and phytosterol low erucic acid rapeseed oil glyceride into ethylhexyl palmitate, heating and stirring to obtain a uniform system, adding caprylic/capric triglyceride, and cooling to obtain phase A; (the effect of temperature reduction is to reduce the damage of high temperature to effective substances)

(2) Mixing BAIHUAYUPINGYOU, oleum Alpiniae Oxyphyllae, and cyclomethicone, and stirring to obtain phase B.

(3) And adding the phase B, the bisabolol and the tocopherol acetate into the phase A, mixing, homogenizing to obtain transparent liquid, and thus obtaining the multi-effect repair oil for infants.

Further, the heating temperature in the step (1) is 55-65 ℃, and preferably 60 ℃; the cooling temperature is 35-45 ℃, and preferably 40 ℃.

Further, the time for homogenization in step (3) is preferably 1min, and the homogenization rotation speed is 2000 r/min.

Advantageous effects

The multi-effect repair oil for infants and children can have the following beneficial effects:

1. according to the multi-effect repair oil for infants, a layer of oil film can be slowly formed on the surface of skin by utilizing base oil (caprylic/capric triglyceride, ethylhexyl palmitate), effective substances are dissolved in the base oil, and the effective substances dissolved in the oil film can be slowly released to act on the skin, so that harmful substances can be isolated for a long time, and the skin can be repaired and repaired for a long time.

2. The effective substances of the invention, oryzanol, bisabolol, phytosterol, Baihuayupingan oil and Yibao oil, all belong to plant extracts, thereby improving the safety of the multi-effect oil, and being mild and non-irritant.

3. The invention has the advantages of scientific compatibility of the components, synergistic effect, simple preparation process and easy implementation.

Drawings

FIG. 1 is a graph comparing the results of a face trial of the sample of example 1;

FIG. 2 is a graph comparing the results of the sample of example 1 on both faces of a volunteer;

FIG. 3 is a graph comparing the effect of the sample of example 1 on the three faces of volunteers;

FIG. 4 is a graph comparing the effect of the sample of example 1 on four faces of volunteers;

FIG. 5 is a graph comparing the results of a sample of example 1 on five legs of a volunteer;

FIG. 6 is a graph comparing the results of the sample of example 1 on six legs of a volunteer.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to the embodiments and the accompanying fig. 1 to 6, but it will be understood by those skilled in the art that the following embodiments and examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. Those who do not specify the conditions are performed according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The component details are as follows:

phytosterol canola glycerides: is prepared by the esterification reaction of phytosterol and rapeseed oil fat. Phytosterol esters have a melting point close to that of the replacement, enhance skin hydration, improve skin barrier, and are excellent emollients, having good skin care properties and pleasant skin feel for the user.

The bisabolol is a main active ingredient of the traditional herbal medicine of the chamomile, has good and effective protection and relieving effects on the skin, and particularly has the anti-inflammatory characteristic and is widely applied to sensitive skin repair and care products for adults.

Baihuayupingyou (Baihuayupingyou): according to the principle of 'monarch, minister, assistant and guide' formula, the skin-care product is prepared by combining safflower, gardenia, Hangzhou white chrysanthemum and flos Pruni mume , and has the effects of remarkably promoting peroxidase proliferation and activating receptor expression, promoting epidermal differentiation, enhancing the vitality of an active epidermal layer and accelerating skin barrier repair.

Beneficial and stored oil: the skin care cream is a raw material compounded by sunflower seed oil, peony seed oil, grape seed oil and perilla seed oil, can balance skin nutrition, and can supplement essential fatty acid, vitamins and minerals for skin, thereby effectively improving skin metabolism, promoting skin repair, reducing skin roughness, locking water, moisturizing and moistening skin.

Example 1: the technical scheme comprises

(1) 0.08 wt% of oryzanol and 1 wt% of phytosterol canola oil glycerides are added into 22 wt% of ethylhexyl palmitate, heated to 60 ℃ and stirred to obtain a uniform system. Then 38 wt% of caprylic/capric triglyceride is added, and the system begins to cool. As phase A

(2) And (3) cooling the phase A, and uniformly stirring 10% of Baihuayupingan oil, 10 wt% of beneficial oil and 18 wt% of cyclomethicone to obtain a phase B.

(3) And after the phase A is cooled to below 45 ℃, respectively adding the phase B, 0.2 wt% of bisabolol and 0.6 wt% of tocopherol acetate into the phase A, mixing, homogenizing, and obtaining transparent liquid, namely the multi-effect repair oil for infants.

In this embodiment, a plurality of different component proportion experiments are performed, and the range of the component proportion includes: 30-50 wt% of caprylic/capric triglyceride, 0.02-0.2 wt% of oryzanol, 0.2-2 wt% of phytosterol and low erucic acid rapeseed glyceride, 15-25 wt% of ethylhexyl palmitate, 0.02-0.2 wt% of bisabolol, 0.1-1 wt% of tocopheryl acetate, 5-15 wt% of lily jade screen oil, 5-15 wt% of beneficial oil and the balance of cyclopolydimethylsiloxane. Within this composition range, samples were prepared with similar properties. The jatropha oil and the beneficial oil are purchased from vast Sen company in Oriental China.

Example 2: phytosterol deletion control group

(1) 0.08 wt% of oryzanol was added to 22 wt% of ethylhexyl palmitate, heated to 60 ℃ and stirred to obtain a homogeneous system. Then 38 wt% of caprylic/capric triglyceride is added, and the system begins to cool. As phase A

(2) And (3) cooling the phase A, and uniformly stirring 10 wt% of Baihuayupingan oil, 10 wt% of beneficial oil and 18 wt% of cyclomethicone to obtain a phase B.

Example 3: lack of beneficial oil

(2) And (3) cooling the phase A, and uniformly stirring 20 wt% of Baihuayupingan oil and 18 wt% of cyclomethicone to obtain a phase B.

Example 4: baihuayupingyou deletion control group

(2) And (3) cooling the phase A, and uniformly stirring 20 wt% of beneficial oil and 18 wt% of cyclomethicone to obtain a phase B.

Example 5: camellia seed oil and olive oil substitute for Baihuayupingan oil and beneficial storage oil

(1) 0.08 wt% of oryzanol and 1 wt% of phytosterol canola oil glyceride are added into 22 wt% of ethylhexyl palmitate, heated to 60 ℃ and stirred to obtain a uniform system. Then 38 wt% of caprylic/capric triglyceride is added, and the system begins to cool. As phase A

(2) And (3) cooling the phase A, and uniformly stirring 10 wt% of camellia oil, 10 wt% of olive oil and 18 wt% of cyclomethicone to obtain a phase B.

Example 6: control group using volatile oil instead of film-forming oil

(1) 0.08 wt% of oryzanol and 1 wt% of phytosterol canola oil glyceride are added into 22 wt% of cyclomethicone, heated to 60 ℃ and stirred to obtain a uniform system. Then 38 wt% of cyclopolydimethylsiloxane is added, and the system begins to cool. As phase A

EXAMPLES sample skin irritation detection test

The detection method comprises the following steps: perform CNAS-CL 01: 2018 detection and calibration laboratory capability acceptance criteria (equivalent to ISO/IEC 17025: 2017).

Detecting a sample: example 1

Experimental animals:

1. line and grade: new Zealand rabbits, normal grade (recommended for use according to the skin irritation/corrosivity test method, 2015 edition, technical Specification for cosmetic safety).

2. Number and sex: 4, 2 males and 2 females.

3. Weight: 2.50-2.55 kg.

4. Providing a unit: provided by the flowerbore district florists laboratory animal farm in Guangzhou City [ animal production license number: SCXK (Yue) 2019-: 44007600007089].

5. Feeding management: the New Zealand rabbits are bred in a common animal room (the experimental animals use license number: SYXK (Guangdong) 2016-. The animal room conditions are kept stable all the time to ensure the reliability of the test results. The granulated feed is provided by cooperative medical bioengineering, llc of Jiangsu province (quality certification number: 20191206).

6. And (3) quarantine: and (3) carrying out quarantine on the purchased common-grade New Zealand rabbits for 3 d. During the period, the animals are checked once a day, unhealthy animals are not found, and healthy New Zealand rabbits are selected for experiments.

Example 1 sample dosage: according to the skin irritation/corrosivity test method of the technical Specification for cosmetic safety 2015 edition, the general-grade New Zealand rabbits qualified in quarantine are directly used for multiple skin irritation tests.

The experimental method comprises the following steps: 4 common-grade New Zealand rabbits, each half of the female rabbit and the male rabbit. Before the test, the hair on both sides of the spine of the back of the experimental animal is cut off, and the hair removing range is about 3cm multiplied by 3cm respectively on the left side and the right side. Applying about 0.5ml of the test substance on the left skin of the animal, applying the test substance on the left skin of the animal for 1 time per day (about 2.5cm × 2.5 cm), and continuously applying the test substance for 14 days while using the other side as a blank control. Shearing hair before each smearing from the next day, removing residual test substance with purified water, and treating the control area. The results were observed after one hour.

And (3) observation operation: the skin reactions were observed under natural light and skin erythema and edema were scored according to the scoring criteria given in table 1 for 14 consecutive days.

And (4) judging a result: the average integral for each experimental animal was calculated according to the following company and is shown in the table.

Average per animal per day ═ Σ integration of erythema and edema/number of animals tested)/14

Table 1: skin irritation response score

Table 2: skin irritation intensity grading

Integral mean value	Strength of
		0～0.5	Has no irritation
0.5～2.0	Light irritation
		2.0～6.0	Middle irritation
6.0～8.0	Strong irritation

The experimental results are as follows:

the skin irritation response of the skin of the tested new zealand rabbits appeared erythematous and edematous during the observation period, and the mean value of the integration of the sample groups per animal per day was 0.09 points. The multiple skin irritation intensity of the sample of example 1 was non-irritating as judged by the skin irritation/corrosion test standards in the technical cosmetic safety Specification (2015 edition). The results are shown in Table 3.

Table 3 example 1 results of multiple skin irritation tests on new zealand rabbits with samples

And (4) experimental conclusion: according to the judgment standard of skin irritation/corrosion test of technical Specification for cosmetic safety 2015 edition, the sample of example 1 is non-irritant to the skin irritation strength by multiple skin irritation tests.

Effectiveness test

Subject: 35 volunteers, 22 children under 3 years old and 13 children 3-12 years old.

Table 4 subject symptom statistics table:

skin problems of the subject	Number of subjects
		Drying and peeling scraps	29
Is prone to reddening	19
		Allergy (S)	2
Inflammation of redness	4
		Red butt of baby	1
Redness in the fold	1
		Health care	0
Others	1

Table 5 usage effect statistics table:

table 6 facial base care oil use experience questionnaire:

and (4) conclusion of effectiveness experiment: in the effectiveness test, 35 pieces of trial feedback are received. The infants (under 3 years old) accounted for 62.86% and the children (3-12 years old) accounted for 37.17% of the subjects. As shown in the attached drawings 1-6, the dry skin symptom accounts for 82.86% in the trial; the skin improvement rate of the test person is 57 percent in three days, 14 percent in 5 days and 20 percent in 7 days; when the facial basic skin care oil is used, 60% of the test persons feel appropriate, fresh and non-greasy, 31% of the test persons feel appropriate but slightly greasy, 80% of the test persons feel light and appropriate in smell, and all the test persons do not have allergy. Generally, the soothing oil has obvious effects on dryness, skin cracking, redness and the like, can make the skin smooth and fine after long-term use, and can relieve the skin redness in winter and the like.

Examples and comparative examples 2 to 6 effectiveness evaluation experiments:

the skin irritation test method and the effectiveness test method of the samples of the embodiments are adopted to respectively test the irritation of the samples of the embodiments 1 to 6, and the results are shown in the table

From the above experimental data it can be derived:

(1) example 1 comparative examples 2-4, the phytosterols canola oil glycerides, the lily jade screen oil and the benefit oil have good synergistic effect and reduce skin irritation. The Baihuayupingyou and Yibao oil are especially obvious in irritation reduction.

(2) Example 1 comparison of example 5, example 5 substituting camellia oil and olive oil for Baihuayupingan oil and beneficial oil, again demonstrates that Baihuayupingan oil and beneficial oil have good irritation reducing effects

(3) Example 1 comparison of example 6, with a volatile oil instead of a film-forming oil, resulted in a rapid effect of the active on the skin, resulting in irritation. Thus, the effect of the film-forming grease in the formula contributing to the reduction of irritation was verified.

Claims

1. A multi-effect repair oil for infants and children, which is characterized by comprising the following components: caprylic/capric triglyceride, oryzanol, phytosterol canola oil glycerides, ethylhexyl palmitate, bisabolol, tocopheryl acetate, jaspe screen oil, shelf oil, cyclomethicone.

2. The multi-effect repairing oil for infants according to claim 1, wherein the multi-effect repairing oil comprises 30-50 wt% of caprylic/capric triglyceride, 0.02-0.2 wt% of oryzanol, 0.2-2 wt% of phytosterol low erucic acid rapeseed oil glyceride, 15-25 wt% of ethylhexyl palmitate, 0.02-0.2 wt% of bisabolol, 0.1-1 wt% of tocopheryl acetate, 5-15 wt% of calathea, 5-15 wt% of beneficial oil, and the balance of cyclomethicone.

3. The multi-effect repairing oil for infants according to claim 1, wherein the multi-effect repairing oil comprises 35 to 45 wt% of caprylic/capric triglyceride, 0.05 to 0.15 wt% of oryzanol, 0.5 to 2 wt% of phytosterol and low erucic acid rapeseed glycerides, 18 to 24 wt% of ethylhexyl palmitate, 0.05 to 0.2 wt% of bisabolol, 0.3 to 0.8 wt% of tocopheryl acetate, 5 to 15 wt% of calathea, 5 to 15 wt% of beneficial oil, and the balance of cyclomethicone.

4. The multi-effect repair oil for infants and young children according to claim 1, wherein the multi-effect repair oil comprises 38-42 wt% of caprylic/capric triglyceride, 0.08-0.12 wt% of oryzanol, 0.8-1.5 wt% of phytosterol and low erucic acid rapeseed glycerides, 20-22 wt% of ethylhexyl palmitate, 0.08-0.12 wt% of bisabolol, 0.4-0.6 wt% of tocopherol acetate, 8-12 wt% of calathea alba oil, 8-12 wt% of beneficial oil, and the balance of cyclomethicone.

5. The multi-effect repairing oil for infants and children according to any one of claims 1 to 4, wherein the Baihuayu screen oil component comprises: sunflower seed oil, safflower extract, gardenia extract, chrysanthemum extract, plum blossom extract and butylated hydroxytoluene.

6. A method for preparing a multi-effect repair oil for infants and children is characterized by comprising the following steps:

(1) adding oryzanol and phytosterol low erucic acid rapeseed oil glyceride into ethylhexyl palmitate, heating and stirring to obtain a uniform system, adding caprylic/capric triglyceride, and cooling to obtain phase A;

(2) uniformly stirring Baihuayupingan oil, beneficial oil and cyclomethicone to obtain a phase B;

(3) adding phase B, bisabolol, and tocopherol acetate into phase A, mixing and homogenizing.

7. The method for preparing the multi-effect repairing oil for infants according to claim 6, wherein the heating temperature in the step (1) is 55-65 ℃.

8. The method for preparing the multi-effect repair oil for infants and children as claimed in claim 6, wherein the temperature of the temperature reduction in the step (1) is 35-45 ℃.

9. The method for preparing the multi-effect repair oil for infants and children according to claim 6, wherein the temperature of the heating in the step (1) is 60 ℃ and the temperature of the cooling is 40 ℃.