CN110448486A - It is a kind of to repair the impaired essential oils of sebum film - Google Patents

It is a kind of to repair the impaired essential oils of sebum film Download PDF

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CN110448486A
CN110448486A CN201910748799.5A CN201910748799A CN110448486A CN 110448486 A CN110448486 A CN 110448486A CN 201910748799 A CN201910748799 A CN 201910748799A CN 110448486 A CN110448486 A CN 110448486A
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parts
extract
seed oil
impaired
essential oils
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CN110448486B (en
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吴文基
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Guangzhou Rui Xi Biochemical Technology Co Ltd
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Guangzhou Rui Xi Biochemical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses one kind can repair the impaired essential oils of sebum film.The essential oils include sunflower seed oil, camellia seed oil, safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract.The present invention selects sunflower seed oil and camellia oil as oily components, using safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract as main active, the impaired sebum film of reparation can be effectively cooperateed with, skin moisture content is improved, reduces skin allergy rate.

Description

It is a kind of to repair the impaired essential oils of sebum film
Technical field
The present invention relates to cosmetic technical fields, and in particular to one kind can repair the impaired essential oils of sebum film.
Background technique
Skin is the important barrier for protecting human body not encroached on by external environment as the maximum organ of human body.And sebum film As the natural protective film of skin, skin can be helped to store moisture, maintain the moisturizing state and barrier function of skin, resisted outer The stimulation and injury come.Due to outside climatic, ultraviolet light, temperature, using the influence of the factors such as chemicals, will affect sebum film Formation, or cause sebum film impaired, and then the barrier function of skin is caused to be weakened, accelerate the loss of moisture, be also easier to By the injury of environmental stimuli and environmental change, causes phenomena such as red and swollen, part is general red, aggravate the sensitivity of skin.At present It can be damaged sebum film by components reparations such as supplement trehalose, hyaluronic acid, chitosans in clinical research, but currently on the market still Lack and effectively repairs the impaired skin-protection product of sebum film.
Summary of the invention
It is an object of the invention to a kind of essence that can be repaired sebum film and be damaged is provided in place of overcome the deficiencies in the prior art Magnificent oil.
To achieve the above object, the technical solution adopted by the present invention is as follows:
It is a kind of to repair the impaired essential oils of sebum film, including sunflower (HELIANTHUS ANNUUS) seed oil, camellia (CAMELLIA JAPONICA) seed oil, safflower (CARTHAMUS TINCTORIUS) flower extract, gardenia (GARDENIA FLORIDA) extract, chrysanthemum (CHRYSANTHEMUM MORIFOLIUM) extract and plum blossom (PRUNUS MUME) extract.
The present invention selects sunflower seed oil and camellia oil as oily components, with safflower flower extract, cape jasmine flower extract, Chrysanthemum extract and Flos Mume extract can effectively cooperate with the impaired sebum film of reparation, improve skin water as main active Divide content, reduces skin allergy rate.
Preferably, the impaired essential oils of sebum film of repairing comprise the following components in parts by weight: sunflower seed oil 5- 10 parts, 5-10 parts of camellia seed oil, 3-8 parts of safflower flower extract, 1-5 parts of cape jasmine flower extract, 1-5 parts of chrysanthemum extract and plum blossom 1-5 parts of extract.
Preferably, the weight ratio of the sunflower seed oil and camellia seed oil is 2-4:1.Sunflower seed oil and camellia seed oil are made For oily components skin surface moisture drain evaporation can be reduced, is sought for skin in the film of skin surface formation layer Moderately good moisturizing environment is made, there is certain facilitation to skin barrier reparation.It is preferred that sunflower seed oil and camellia seed The proportion of oil, the essential oils moistening effect being prepared are preferable.
Preferably, the weight ratio 7 of the safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract: 2:2:3.Pass through the proportion of preferred safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract, the essence of preparation Magnificent oil has preferable moisturizing, anti-oxidant and antiphlogistic effects, helps to repair impaired sebum film.
Preferably, essential oils further include auxiliary material.
Preferably, the auxiliary material includes caprylic/capric triglyceride, bisabolol, phytosterol/octyl dodecanol laurel At least one of acyl glutamate, tocopherol acetate.
Caprylic/capric triglyceride has the effect of lubrication and soft skin, can be used as emollients, solvent, permeation enhancers; The effect of bisabolol has excellent anti-inflammatory anti-inflammatory, accelerates skin metabolism, accelerates skin healing;Phytosterol/octyl Lauryl alcohol lauroyl glutamate ester is a kind of good emollient, has the effect of soft and moist skin;Tocopherol acetate has anti- Oxidation effectiveness and the effect for keeping skin moisture.By adding said components, the impaired essence of sebum film can be repaired by helping to improve The using effect of magnificent oil.
Preferably, the essential oils comprise the following components in parts by weight: 60-70 parts of caprylic/capric triglyceride, sunflower 5-10 parts of seed oil, 5-10 parts of camellia seed oil, 3-8 parts of safflower flower extract, 1-5 parts of cape jasmine flower extract, chrysanthemum extract 1-5 Part, 1-5 parts of Flos Mume extract, 0.1-0.2 parts of bisabolol, phytosterol/octyl dodecanol lauroyl glutamate ester 0.1-0.5 Part and tocopherol acetate 0.5-1 parts.
Compared with prior art, the invention has the benefit that
Essential oils of the invention select sunflower seed oil and camellia oil as oily components, with safflower flower extract, cape jasmine Flower extract, chrysanthemum extract and Flos Mume extract can speed up skin metabolism as main active, effectively repair Impaired sebum film, improves skin moisture content, reduces skin allergy rate, has and nourishes Shu Min, mild non-stimulated effect.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention It further illustrates.It will be appreciated by those skilled in the art that described herein, specific examples are only used to explain the present invention, not For limiting the present invention.
In embodiment, used experimental method is conventional method unless otherwise specified, material used, reagent etc., It is commercially available unless otherwise specified.
Embodiment 1
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 5 parts of sunflower seed oil, 10 parts of camellia seed oil, 8 parts of safflower flower extract, 2 parts of cape jasmine flower extract, 3 parts of chrysanthemum extract, 1 part of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 2
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 8 parts of safflower flower extract, 2 parts of cape jasmine flower extract, 3 parts of chrysanthemum extract, 1 part of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 3
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 12 parts of sunflower seed oil, 3 parts of camellia seed oil, 8 parts of safflower flower extract, 2 parts of cape jasmine flower extract, 3 parts of chrysanthemum extract, 1 part of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 4
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 7 parts of safflower flower extract, 2 parts of cape jasmine flower extract, 2 parts of chrysanthemum extract, 3 parts of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 5
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 7 parts of safflower flower extract, 2 parts of cape jasmine flower extract, 1 part of chrysanthemum extract, 4 parts of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 6
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 6 parts of safflower flower extract, 5 parts of cape jasmine flower extract, 1 part of chrysanthemum extract, 2 parts of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 7
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 3 parts of safflower flower extract, 1 part of cape jasmine flower extract, 5 parts of chrysanthemum extract, 5 parts of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.7 part of acid esters.
Embodiment 8
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 60 Part, 10 parts of sunflower seed oil, 10 parts of camellia seed oil, 5 parts of safflower flower extract, 5 parts of cape jasmine flower extract, 5 parts of chrysanthemum extract, 4 parts of Flos Mume extract, 0.2 part of bisabolol, phytosterol/0.3 part of octyl dodecanol lauroyl glutamate ester and tocopherol second 0.5 part of acid esters.
Embodiment 9
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 65 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 7 parts of safflower flower extract, 1.4 parts of cape jasmine flower extract, chrysanthemum extract 5 Part, 5 parts of Flos Mume extract, 0.1 part of bisabolol, phytosterol/0.5 part of octyl dodecanol lauroyl glutamate ester and tocopherol 1 part of acetic acid esters.
Comparative example 1
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of camellia seed oil, 7 parts of safflower flower extract, 7 parts of cape jasmine flower extract, 0.1 part of bisabolol, Phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and 0.7 part of tocopherol acetate.
Comparative example 2
It is a kind of to repair the impaired essential oils of sebum film, it comprises the following components in parts by weight: caprylic/capric triglyceride 70 Part, 10 parts of sunflower seed oil, 5 parts of coconut oil, 7 parts of safflower flower extract, 2 parts of cape jasmine flower extract, 2 parts of chrysanthemum extract, plum 3 parts of flower extract, 0.1 part of bisabolol, phytosterol/0.2 part of octyl dodecanol lauroyl glutamate ester and tocopheryl acetate 0.7 part of ester.
1, ABTS free radical scavenging ability
Sample solution concentration is 0.01%.It is 7mmol/L by ABTS compound concentration, potassium peroxydisulfate is configured to 2.45mmol/ L mixes the two solution, is placed in dark, stirs 16h under room temperature;Then by ABTS mixed solution PBS solution (PH =7.0) being diluted to its light absorption value (surveying at 734nm) is 0.70 ± 0.02;Sample solution is added in ABTS mixed solution, Its sample and ABTS mixed solution ratio are 1: 20, are incubated for 6min after mixing at room temperature, and light absorption value, root are measured at 734nm ABTS clearance rate is calculated according to following formula, the results are shown in Table 1:
ABTS clearance rate=(1-A1/A0) × 100% (1)
Wherein A0For the light absorption value of ABTS mixed solution;A1For the light absorption value measured after sample is added in ABTS mixed solution.
1 ABTS clearance rate of table
Group ABTS clearance rate/%
Embodiment 1 82.6
Embodiment 2 83.2
Embodiment 3 82.1
Embodiment 4 89.3
Embodiment 5 86.7
Embodiment 6 80.8
Embodiment 7 75.8
Embodiment 8 91.2
Embodiment 9 92.4
Comparative example 1 68.5
Comparative example 2 89.1
As seen from the results in Table 1, composition of the invention has excellent antioxidant activity, helps to improve the tolerance of skin Property, repair impaired sebum film.Wherein, by embodiment 2,4-7 and 1 result of comparative example it is found that identical in active constituent total content In the case of, safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract weight ratio 7:2:2:3 when, antioxygen Change better effect.
2, inhibit the measurement of hyaluronidase ability
Sample solution concentration is 0.01%.Take 0.1mL 2.5mmol/L CaCl2Solution and 0.5mL hyaluronic acid enzyme solution 37 DEG C heat insulating culture 20min;Sample liquid 0.5mL is added, in 37 DEG C of heat insulating culture 20min;37 DEG C of 0.5mL Sodium Hyaluronate liquid is added Keep the temperature 30min, room temperature 5min;0.1mL0.4mol/L NaOH solution and 0.5mL acetylacetone,2,4-pentanedione solution is added, is placed in boiling water Cooling 5min is carried out with ice water immediately after heating 15min in bath;Color developing agent 1.0mL is added sufficiently to vibrate, and with the anhydrous second of 3.0mL Alcohol is diluted, and is placed 20min colour developing, is measured its absorbance value, calculates sample to hyaluronic acid enzyme inhibition rate by formula (2), The results are shown in Table 2.
Hyaluronic acid enzyme inhibition rate=((B1-B2)-(B3-B4)) × 100%/(B1-B2) (2)
B in formula1--- contrast solution ABS value (replaces sample solution with hac buffer)
B2--- control blank solution ABS value (replacing sample solution and enzyme solution with hac buffer)
B3--- sample solution ABS value
B4--- sample blank solution A BS value (replacing enzyme solution with hac buffer)
2 hyaluronic acid enzyme inhibition rate of table
Group Hyaluronic acid enzyme inhibition rate (%)
Embodiment 1 41.6
Embodiment 2 41.8
Embodiment 3 41.4
Embodiment 4 49.3
Embodiment 5 48.8
Embodiment 6 39.3
Embodiment 7 42.7
Comparative example 1 33.8
Comparative example 2 49.1
It can be seen from 2 result of table in the identical situation of active constituent total content, by adjusting safflower flower in essential oils The ratio of extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract can be improved hyaluronic acid enzyme inhibition rate, when Safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract weight ratio 7:2:2:3 when, hyaluronidase Inhibiting rate is higher, it is seen that the essential oils of this formula have preferable Shu Min anti-irritant effect.
3, moisture determination
Using essential oils made from Examples 1 to 7 and comparative example 1-2 as using sample, every group select 10 ages 18~ 45 years old triers measure the water content of stratum corneum and record of trier, smear and protect in face skin after the daily face cleaning of trier Skin composition measures the water content of stratum corneum of trier after continuous use 4 weeks, calculate its water content of stratum corneum by formula (3) and increase Add rate, the results are shown in Table 1.
Water content of stratum corneum increment rate=(C2-C1) × 100%/C1 (3)
C1--- use procuticle water content
C2--- use water content of stratum corneum after 4 weeks
3 water content of stratum corneum increment rate of table
Group Water content of stratum corneum increment rate (%)
Embodiment 1 15.5
Embodiment 2 22.8
Embodiment 3 20.1
Embodiment 4 28.5
Embodiment 5 26.8
Embodiment 6 27.2
Embodiment 7 26.5
Comparative example 1 12.7
Comparative example 2 8.4
The moisture content for promoting keratoderma peomotes the formation of water and grease sebum film in cuticula.By implementing Example 1-3 and comparative example 2 have good moist guarantor as can be seen that sunflower seed oil and camellia seed oil compounding are used as oily components Wet effect can build moderately good moisturizing environment for skin, have certain facilitation to skin barrier reparation.By reality Apply a 4-7 and comparative example 1 it is found that safflower flower extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract is compound can The function for effectively adjusting skin cell, has effects that good moisturizing water lock.The present invention by preferred oily components and activity at The type and proportion divided make it have the effect of collaboration improves the water content of skin.
4, effect assessment
Using embodiment 4-7 and the essential oils of comparative example 1 as trial product, the age 18-45 years old 100 people of trier is selected, On probation and clinical observation is carried out, inclusion criteria is the appearance sensitive for carrying out facial laser, oedema, the patient of erythema, tool There is the patient of the symptoms such as dry furfur, itch or shouting pain, is randomly divided into 5 groups, every group of 20 people.After daily face cleaning, in face skin Essential oils are smeared once in the morning and once at night to use one month.
Observe the symptoms: itch, erythema, oedema, exudation, dry furfur, shouting pain etc., respectively by without, it is light, in, weight grade note It is 0,1,2,3 point.
Judgment criteria:
(1) fully recover: symptom integral reduces >=95%;
(2) effectively: symptom integral reduces 70%~95%;
(3) invalid: symptom integral reduces < 30%.
4 effect assessment of table
Group Cure rate (%) Efficient (%) Inefficiency (%)
Embodiment 4 20 50 10
Embodiment 5 20 40 10
Embodiment 6 10 40 15
Embodiment 7 10 25 15
Comparative example 1 5 15 15
By the effect assessment result of table 4 it is found that the present invention is extracted using a certain proportion of safflower flower extract, gardenia Object, chrysanthemum extract and the compound essential oils of Flos Mume extract to repairing because of facial laser, allergy caused by damaged skin barrier Have the effect of certain, and there is no phenomena such as allergy, skin is uncomfortable occur, it is mild to skin safe, it stimulates smaller.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention And range.

Claims (7)

1. one kind can repair the impaired essential oils of sebum film, which is characterized in that including sunflower seed oil, camellia seed oil, safflower flower Extract, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract.
2. according to claim 1 repair the impaired essential oils of sebum film, which is characterized in that including following parts by weight Component: 5-10 parts of sunflower seed oil, 5-10 parts of camellia seed oil, 3-8 parts of safflower flower extract, 1-5 parts of cape jasmine flower extract, chrysanthemum 1-5 parts and Flos Mume extract 1-5 parts of extract.
3. according to claim 2 repair the impaired essential oils of sebum film, which is characterized in that the sunflower seed oil and The weight ratio of camellia seed oil is 2-4:1.
4. according to claim 2 repair the impaired essential oils of sebum film, which is characterized in that the safflower flower extracts Object, cape jasmine flower extract, chrysanthemum extract and Flos Mume extract weight ratio 7:2:2:3.
5. according to claim 1-4 repair the impaired essential oils of sebum film, which is characterized in that further include auxiliary Material.
6. according to claim 5 repair the impaired essential oils of sebum film, which is characterized in that the auxiliary material includes pungent In acid/Triglyceride DDD, bisabolol, phytosterol/octyl dodecanol lauroyl glutamate ester, tocopherol acetate extremely Few one kind.
7. according to claim 6 repair the impaired essential oils of sebum film, which is characterized in that including following parts by weight Component: 60-70 parts of caprylic/capric triglyceride, 5-10 parts of sunflower seed oil, 5-10 parts of camellia seed oil, safflower flower extract 3-8 Part, 1-5 parts of cape jasmine flower extract, 1-5 parts of chrysanthemum extract, 1-5 parts of Flos Mume extract, 0.1-0.2 parts of bisabolol, plant steroid Alcohol/0.1-0.5 parts of octyl dodecanol lauroyl glutamate ester and tocopherol acetate 0.5-1 parts.
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CN111096939A (en) * 2020-01-20 2020-05-05 猫头鹰(福州)日用品有限公司 Multifunctional refreshing essence oil and preparation method thereof
CN111265437A (en) * 2020-04-10 2020-06-12 中山爱护日用品有限公司 Multi-effect repair oil for infants and children and preparation method thereof
CN111700828A (en) * 2020-05-30 2020-09-25 杭州心悦化妆品有限公司 Oil-control repairing concealer and production process thereof
CN112089654A (en) * 2020-09-03 2020-12-18 铂臻(广州)生物科技有限公司 Acne-removing composition and application thereof
WO2021218039A1 (en) * 2020-04-29 2021-11-04 上海林清轩生物科技有限公司 Biomimetic and camellia extract-containing skin barrier repair composition and application thereof
CN114159347A (en) * 2021-11-08 2022-03-11 广州那比昂生物科技有限公司 Composition with whitening and repairing effects and preparation method and application thereof
CN115737495A (en) * 2022-10-26 2023-03-07 现代百朗德生物科技(江苏)有限公司 Siji flower essence extracting solution with anti-inflammatory, antioxidant, whitening and anti-wrinkle effects and preparation method thereof

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