WO2011012737A1 - Combination of active cosmetic ingredients and cosmetic composition obtained therefrom and use thereof - Google Patents
Combination of active cosmetic ingredients and cosmetic composition obtained therefrom and use thereof Download PDFInfo
- Publication number
- WO2011012737A1 WO2011012737A1 PCT/ES2010/000115 ES2010000115W WO2011012737A1 WO 2011012737 A1 WO2011012737 A1 WO 2011012737A1 ES 2010000115 W ES2010000115 W ES 2010000115W WO 2011012737 A1 WO2011012737 A1 WO 2011012737A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- cosmetic
- panthenol
- combination
- skin
- Prior art date
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Definitions
- the present invention relates to a new combination of cosmetic active ingredients with antioxidant properties that can be used to reduce the effects of irritating aggressions to the skin.
- State of the prior art
- compositions are described to reduce the effects of chronological aging and skin photoaging.
- Such compositions include, as active components, an agonist of the liver X receptors (Liver-X-Receptor, LXR) and retinoic acid or a precursor thereof.
- Liver-X-Receptor LXR
- retinoic acid or a precursor thereof.
- the resin of dragon blood from the Daemorgos draco tree, is cited.
- topical compositions are described to increase the synthesis in the skin of decorin and fibronectin, connective tissue proteins, and, thereby, reduce the effects of chronological aging and photoaging of Ia skin. More specifically, an oil-in-water (O / W) type emulsion containing dragon blood resin from the dragon tree Daemonorops tree is described.
- O / W oil-in-water
- compositions that include extracts of C. lechler ⁇ as the main active ingredient and that are suitable for the treatment of small cuts, abrasions and wounds in the skin.
- Said compositions include cosmetic components for obtaining creams, ointments, lotions, emulsions of the water-in-oil type (W / O), emulsions of the oil-in-water type (O / W).
- Formulations that include other active ingredients, for example antibiotics and local anesthetics, are also described to obtain complementary effects.
- An object of the invention is a combination of cosmetic active ingredients. Also an integral part of the invention is a cosmetic composition that includes said combination.
- Another object of the invention is the use of said combination in the preparation of a cosmetic composition to reduce the effects of aggressions on the skin. It is also the object of the invention to use the cosmetic composition obtained from the combination of the invention to reduce the effects of aggressions on the skin.
- Also part of the object of the invention is a method for reducing the effects of aggressions on the skin, which comprises applying a cosmetically effective amount of the composition or combination of the invention on the skin.
- an object of the present invention is a combination of active cosmetic ingredients comprising: a) Croton lechle ⁇ resin, and b) panthenol.
- the proportion between Crotón lechler ⁇ resin and panthenol is between 1: 500 and 1: 2, expressed in weight: weight, preferably between 1: 200 and 1: 10, especially between 1: 100 and 1: 20, with special preference between 1: 50 and 1: 30 and in particular between 1: 45 and 1: 35.
- the particularly preferred ratio is 1: 40.
- the cosmetic composition of the invention includes a combination of active ingredients consisting essentially of Croton lechler ⁇ resin and panthenol.
- Crotón lechler ⁇ resin Crotón lechler ⁇ is the scientific name of the tree called
- C. lechler ⁇ A South American Tree Sap in the Treatment of Diarrhea, Inflammation, Insect Bites, Viral Infections, and Wounds: Traditional Uses to Clinical Research, J. Altern. Complem Med., 2003, 9 (6), 877-896, describe the traditional properties and applications of C. lechler ⁇ resin.
- the C. lechleri resin can be found commercially, for example in the form of a hydro-glycol solution (water and propylene glycol), under the name Dragon's Blood, from the Cobiosa company, the resin content being between 1% and 5% in weight.
- Panthenol is a compound that belongs to the group of vitamin B and is transformed to pantothenic acid (vitamin B 5 ) in the skin, so it is also called provitamin B 5 .
- Said compound is well known in the cosmetic industry, since it has been used for years as a skin moisturizing agent, also presenting anti-inflammatory properties.
- Panthenol is a chemical compound that has a chiral carbon atom, therefore existing in the enantiomeric form, of which only D-panthenol (dexpanthenol) is biologically active.
- both enantiomers have moisturizing activity and both D-panthenol and the racemic mixture that includes D-panthenol and L-panthenol can be used in cosmetic compositions.
- panthenol is selected from D-panthenol and the racemic mixture, preferably D-panthenol is used.
- object of the invention is a cosmetic composition
- a cosmetic composition comprising the combination of the invention and a cosmetically acceptable vehicle.
- the combination of the invention can be formulated in the form of cosmetic compositions to facilitate its application.
- such cosmetic compositions contain: - between 1% and 20% by weight of the combination of the invention, and
- compositions of the invention preferably contain between 1.5% and 10% by weight of the combination of the invention, especially between 2% and 8% by weight and especially preferably between 4% and 6% by weight of the combination of invention.
- the composition of the invention contains between 1% and 5% by weight, especially between 2% and 4% by weight and in particular between 2.5% and 3.5% by weight.
- weight of a combination of Croton lechleri and panthenol resin containing between 1% and 5% by weight of resin and between 0.5% and 5% by weight, especially between 1% and 4% in weight and in particular between 1.5% and 3% by weight of panthenol.
- composition of the invention contains 3% by weight of a combination of Croton lechleri and panthenol resin containing between 1.5% and 1.75% by weight of resin and 2 % by weight of panthenol, especially 3% by weight of a combination of Croton lechleri and panthenol containing between 1.5% and 1.75% by weight of resin and 2% by weight of D-panthenol.
- compositions of the invention include a cosmetically acceptable vehicle in which the cosmetic ingredients are dissolved, emulsified, dispersed or suspended.
- Said vehicle is selected from water, a water miscible non-aqueous vehicle, for example ethanol, isopropanol, and a non-aqueous non-aqueous vehicle Water miscible, for example paraffin oil.
- a water miscible non-aqueous vehicle for example ethanol, isopropanol
- a non-aqueous non-aqueous vehicle Water miscible, for example paraffin oil.
- the compositions of the invention include water as a vehicle.
- the cosmetic compositions of the invention contain, in addition to the combination of the invention, at least one additional cosmetic ingredient, for example cosmetic active ingredients, auxiliary products and additional additives, which can be selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickeners, stabilizers, hydrotropes, preservatives, essences, dyes and mixtures thereof. They may also include other components such as silicone compounds, fats, waxes, lecithins, phospholipids, UV sun protection factors, smokers, self tanners or tyrosine inhibitors (depigmentation agents).
- additional cosmetic ingredient for example cosmetic active ingredients, auxiliary products and additional additives, which can be selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickeners, stabilizers, hydrotropes, preservatives, essences, dyes and mixtures thereof. They may also include other components such as silicone compounds, fat
- the cosmetic compositions of the invention contain, in addition to the combination of the invention, an additional cosmetic ingredient selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickening agents, hydrotropes, preservatives and mixtures thereof.
- an additional cosmetic ingredient selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickening agents, hydrotropes, preservatives and mixtures thereof.
- compositions obtained from the combination of ingredients of the present invention can be administered in various cosmetic presentations, preferably these are in the form of sprayable creams, lotions, milks and emulsions.
- Such compositions contain water and a lipophilic phase and are generally in the form of emulsions or dispersions, for example of the oil-in-water type (ONSI), water in oil QNIO), multiple emulsions (W / O / W) or emulsions of the PIT type , as described in Spanish patent ES 2169908-T3, or as microemulsions. They are preferably in the form of an emulsion of the oil-in-water (O / W) type.
- the cosmetic compositions of the invention contain: between 1% and 10% by weight of the combination of the invention,
- the content of additional cosmetic ingredient present in the cosmetic composition of the invention is between 10% and 45% by weight, especially between 15% and 35% by weight and in particular between 20 % and 25% by weight, with respect to the total composition.
- the content of the vehicle present in the cosmetic composition of the invention is comprised between the
- the composition of the invention also includes a cosmetic active ingredient selected from the group consisting of: Centella asiatica extract, aloe vera gel, Rosehip oil, sweet almond oil, shea butter, glycyrrhetic acid, vitamin E and its derivatives, and mixtures thereof.
- a cosmetic active ingredient selected from the group consisting of: Centella asiatica extract, aloe vera gel, Rosehip oil, sweet almond oil, shea butter, glycyrrhetic acid, vitamin E and its derivatives, and mixtures thereof.
- Centella asiatica is a small annual climbing plant of the Apiaceae family, which grows in tropical areas. It is also known by Gotu Kola. The main components of this plant are triterpenic derivatives, abundant tannins, essential oil, phytosterols and mucilages. It is traditionally used for its healing and relaxing power, since it favors the synthesis of collagen.
- Centella asiatica extract is marketed as a hydro-glycolic extract (water and propylene glycol), for example through the Provital company, and has a dry residue comprised between 2.5% and 3.5% by weight.
- the content of extract of Centella asiatica ranges between 1% and 5% by weight, preferably between 2% and 4% by weight, especially between 2.5% and 3, 5% by weight.
- Aloe vera gel is obtained from the succulent Aloe barbadensis plant of the Asphodelaceae family. The leaves of this plant are composed of three layers: an outer leathery protection, a fibrous layer under it and a jelly-like heart where it stores its water reserves and with which pharmaceutical and cosmetic products are prepared.
- the use of aloe vera gel for the treatment of skin conditions is remarkably widespread. In the market you can find the aloe vera gel extracted from the plant with a solids content of approximately 0.5% by weight, and which is called 1: 1 gel.
- the 2: 1 concentrated gel has solids content of about 1% by weight; the 10: 1 concentrated gel has a solids content of about 5% by weight; The 40: 1 concentrated gel has a solids content of approximately 20% by weight.
- Products are also found sprayed 100: 1 and 200: 1, which allow the original gel to be reconstituted by mixing a part of it and 99 parts of water or 1 part and 199 parts of water respectively.
- composition of the invention preferably a 10: 1 concentrated aloe vera gel is used, so that the combination of 1 part of said gel with 9 parts of water leads to the original gel of the plant.
- the 10: 1 concentrated aloe vera gel content ranges between 0.5% and 10% by weight, preferably between 1% and 8% by weight, especially between 2% and 5% and in particular between 2.5% and 4%.
- Rosa mosqueta is a plant belonging to the Rosaceae family, which includes three species: Rosa moschata, Rosa canina and Rosa rubiginosa. It is a shrub with thin, flexible and very thorny branches, which can exceed 2 meters high. At present it is extended by various areas of the planet, especially in temperate regions.
- the oil is extracted from the seeds that contain its fruits. Said oil is used in the cosmetic industry due to the beneficial effects it produces on the skin, for example hydration of aged skin, prevention of stretch marks, and also in the treatment of scars, burns, melanomas, dermatitis and psoriasis.
- the content of Rosehip oil ranges between 0.1% and 5% by weight, preferably between 0.2% and 3% by weight, especially between 0.3% and 1% by weight and in particular between 0.4% and 0.6% by weight.
- Sweet almond oil is obtained from the fruit of the almond tree (Prunus dulc ⁇ s), from the Rosaceae family, which has its origin in the regions of Central Asia. Sweet almond oil gets it can be obtained by means of the cold pressing technique, and the product thus obtained can be further retined to reduce the intensity of the aroma, although some of its properties are also lost in said refining process. Said oil is used in cosmetics for its emollient, softening, moisturizing and anti-inflammatory properties.
- the sweet almond oil content ranges between 1% and 15% by weight, preferably between 2% and 10% by weight, especially between 3% and 8% by weight. and in particular between 4% and 7% by weight.
- Shea butter is obtained from the seeds of the fruit of
- Butyrospermum parkii a tree that grows wild in a wide area of central Africa. Its composition is very complex, and palmitic, stearic, oleic, linoleic acids can be identified, as well as an unsaponifiable fraction that confers a great moisturizing and emollient capacity.
- the content of shea butter ranges between 0.5% and 5% by weight, preferably between 1% and 4% by weight and especially between 1.5% and 3 % in weigh.
- Glycyrrhizinic acid or glycyrrhizinic acid is obtained by hydrolysis of glycyrrhizic acid, which in turn is extracted from licorice root (Glycyrrhiza glabra). Glycyrrhetic acid has soothing, anti-inflammatory and healing properties and, therefore, is used in cosmetics to protect the skin from external aggressions.
- the glycyrrhetic acid content ranges between 0.1% and 3% by weight, preferably between 0.2% and
- Vitamin E or ⁇ -tocopherol is a fat-soluble vitamin that acts as an antioxidant. It is found in many foods, mainly of plant origin, especially those with green leaves, seeds, including broccoli, spinach, soybeans, wheat germ and brewer's yeast; It can also be found in foods of animal origin such as egg yolk.
- vitamin E can also be found in the form of an ester with acetic acid, as in ⁇ -tocopherol acetate. Said compound is less acidic and is the derivative of vitamin E that is commonly used in cosmetic compositions.
- ⁇ -tocopherol acetate is used and its content ranges between 0.05% and 2% by weight, especially between 0.1% and 1% by weight and in particular between 0.15% and 0.5% by weight.
- compositions of the invention may additionally include surfactants to facilitate the solution, emulsion, dispersion or suspension of cosmetic components.
- the surfactants can be anionic, nonionic, cationic and / or amphoteric. Preferably nonionic surfactants are used.
- the content of surfactants is between 1% and 30% by weight, preferably between 2% and 20%, especially between 3% and 10% and in particular between 4% and 8% .
- anionic surfactants are, to name a few, soaps, sulphonated alloys, sulphonated olefins, alkyl sulfates, fatty alcohol ether sulfates, glycerin ether sulfates, fatty acid ether sulfates, mono- and dialkyl sulfosuccinates, mono- and sulfosuccinamates dialkyl, ethercarboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acylamino acids.
- non-ionic surfactants are, among others, polyalkoxylated fatty alcohols, polyalkoxylated fatty acids, polyalkoxylated fatty acid amides, polyalkoxylated fatty amines, alkoxylated triglycerides, mixed ethers, alkyl polyglycosides, fatty acid N-alkyl glucamides, esters, esters, esters of polyethoxylated sorbitan and amine oxides.
- Typical examples of cationic surfactants are, among others, quaternary ammonium compounds and quaternized salts of trialkanolamine esters and fatty acids, for example Esterquats.
- amphoteric surfactants are, among others, alkyl betaines, alkylamido betaines, aminopropionates, aminoglycinates, imidazolinium betaines and sulfobetaines.
- surfactants these are exclusively known compounds, whose structure and production are well known to those skilled in the art, and can be found, for example, in the book of X. Sunday, A guide to the surfactants world,
- alkyl polyglycosides are especially preferred, especially cetearyl glycoside and in particular a combination thereof with cetearyl alcohol (for example the product MONTANOV ® 68, from the Seppic company, or the product
- Emulgade ® PL 68/50 preferably in combination with myristic alcohol (for example the product MONTANOV ® 14 from the Seppic company).
- Lipid compounds and emollients Lipid compounds and emollients
- compositions of the invention may additionally contain various lipid compounds and additional emollients that contribute to optimize its organoleptic and dermatological properties.
- the total amount of lipid compounds and emollients additionally present in the composition of the invention is between 1 and 50% by weight, preferably between 5 and 25% by weight and especially between 5 and 15% by weight .
- the lipid compounds include Guerbet alcohols based on fatty alcohols with 6 to 18 carbon atoms, preferably with 8 to 10 carbon atoms (for example, the Eutanol ® G product of the Cognis company), esters of linear fatty acids with 6 to 18 carbon atoms (for example, the Eutanol ® G product of the Cognis company), esters of linear fatty acids with 6 to 18 carbon atoms (for example, the Eutanol ® G product of the Cognis company), esters of linear fatty acids with
- 6 to 22 carbon atoms with linear alcohols with 6 to 22 carbon atoms esters of branched carboxylic acids with 6 to 13 carbon atoms with linear alcohols with 6 to 22 carbon atoms, for example myristyl myristate, myristyl palmitate, Myristyl stearate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate or erucilo myristate.
- esters of linear fatty acids with 6 to 22 carbon atoms with branched alcohols are suitable, especially 2- ethylhexanol (for example, the product Cetiol ® 868 from the Cognis company); esters of alkyl hydroxycarboxylic acids of 18 to 38 carbon atoms with fatty alcohols with 6 to 22 linear or branched carbon atoms, especially dioctyl malate; esters of linear and / or branched fatty acids with polyhydric alcohols - and / or Guerbet alcohols; triglycerides based on fatty acids with 6 to 10 carbon atoms (for example the product Mirytol 318 ® from the Cognis company); liquid mixtures of mono / di / triglycerides based on fatty acids with 6 to 18 carbon atoms; esters of fatty alcohols with 6 to 22 carbon atoms and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid; esters of
- compositions of the invention are Eutanol ® G products (Guerbet alcohol: octyldodecanol),
- Cetiol ® 868 (2-ethylhexanol stearate), Cetiol ® CC (dicaprilyl carbonate) and Mirytol 318 ® (caprylic and capric triglycerides) from the Cognis company, and combinations thereof.
- compositions of the invention consistency factors and thickeners are used to adjust the viscosity and the rheological behavior thereof.
- Consistency factors include, in the first place, fatty alcohols with a chain of 12 to 22 carbon atoms, and preferably 16 to 18 carbon atoms, and also partial glycerides, fatty acids or hydroxylated fatty acids.
- Suitable thickening agents are, by way of example, hydrophilic silicic anhydride (for example, Aerosil ® products of the Evonik company); polysaccharides, especially xanthan gum, guar gum, agar-agar, alginates and tyloses, carboxymethylcellulose and hydroxyethylcellulose, in addition to polyethylene glycolmono- and diesters of molecular weight fatty acids plus high; polyacrylates (for example Carbopol ® and Pemulen grades ® of Goodrich company Ia, Ia Synthalens.RTM company Sigma, Keltrol ® types of Ia company Kelgo; Sepigel grades and Simulgel ® ® of Ia SEPPIC; Saleare ® types of Ia Allied
- cetyl alcohol, myristic alcohol, the Simulgel ® EG product of the Seppic company are especially suitable and sodium acryloyl dimethyl restaurant
- Simulgel ® NS from the Seppic company (mixture of squalane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide, and copolymer of hydroxyethyl acrylate and sodium acrylo dimethyl restaurant) and mixtures thereof. Hydrotropes
- hydrotropes for example ethanol, isopropyl alcohol or polyols
- the polyols that come into consideration in this case preferably have from 2 to 15 carbon atoms and at least two hydroxyl groups.
- the polyols may also contain other functional groups, especially amino groups, or be modified with nitrogen.
- Typical examples are glycerin; alkylene glycols, for example ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol, as well as polyethylene glycols with an average molecular weight of 100 to 1,000 dalton; technical mixtures of oligoglycerins with a degree of condensation of their own from 1.5 to 10, for example technical mixtures of diglycerins with a diglycerin content of 40 to 50% by weight; methylol compounds, especially trimethylolmethane, trimethylolpropane, trimethylolbutane, pentaerythrite and dipentaerythrite; alkyl glucosides with a chain from 1 to 8 carbon atoms in the alkyl moiety; saccharic alcohols with 5 to 12 carbon atoms, for example sorbitol or mannitol; sugars with 5 to 12 carbon atoms, for example glucose or sucrose; amino sugars, for example glucamine; dialco
- glycerin, propylene glycol and mixtures thereof are used in the compositions of the invention as a hydrotrope.
- preservative agents suitable for use in the compositions of the invention are, for example, phenoxyethanol, formaldehyde solution, parabens (methylparaben, propylparaben, butylparaben and mixtures thereof), 3- (4-chlorophenox) -1 , 2- propanediol (chlorphenesin), pentanediol or sorbic acid, and the classes of additional substances indicated in Annex Vl of the Cosmetics Directive 76/768 / EEC.
- paraben, chlorphenesin, phenoxyethanol or mixtures thereof, especially phenoxyethanol are used as preservatives, for example, the COBIOSTAT ® 200 product of the Cobiosa company.
- compositions of the invention can be prepared following conventional procedures in the cosmetic industry for the preparation of lotions, milks, creams, and sprayable emulsions.
- the preparation of emulsions is described for example in the Remington manual: The Science and Practice of Pharmacy, 20th edition, Lippincott Williams & Wilkins, Philadelphia, 2000 [ISBN: 0-683-306472].
- a process for preparing a composition of the invention can be, for example, the following.
- a reactor equipped with a stirring equipment weighed and melted at a temperature between 65 0 C and 85 0 C, the lipophilic components and emulsifiers.
- another container are weighed and heated to a temperature between 65 0 C and 85 0 C, hydrophilic components such as water, glycerine, panthenol and preservatives.
- an emulsion is prepared from the lipophilic mass and the hydrophilic components with appropriate agitation.
- the cosmetic composition obtained generally has a viscosity between 100 and 100,000 cps.
- the pH of the composition can be adjusted with citric acid, hydrochloric acid or sodium hydroxide.
- Low viscosity compositions (lotions, PIT emulsions, microemulsions) can also be applied by spraying.
- a cosmetic composition comprising the combination of the invention, which comprises Croton lechleri resin and panthenol, and, as additional active cosmetic ingredients, rosehip oil, shea butter and aloe vera gel.
- a cosmetic composition comprising the combination of the invention, which comprises Croton lechleri resin and panthenol, and, as additional active cosmetic ingredients, Centella asiatica extract, sweet almond oil, Rosehip oil, butter Shea, ⁇ -tocopherol acetate, glycyrrhetic acid and aloe vera gel.
- the use of the combination of the invention to prepare a cosmetic composition is also part of the object of the invention. to reduce the effects of aggressions to the skin.
- the combination of the invention is used to reduce the effects of laser radiation on the skin.
- the use of the cosmetic composition of the invention to reduce the effects of aggressions to the skin is also object of the invention.
- regressions against the skin means damage caused by environmental conditions, for example by exposure to ultraviolet radiation from sunlight, wind, moisture, environmental pollution or cold; aging, for example, dehydration and oxidation; and the laser radiation, for example the dermatological application of laser radiation to remove hair.
- the composition of the invention is used to reduce the effects of laser radiation on the skin.
- a live test was performed on the legs of individuals who underwent a medical laser photodepilation. After said hair removal process, on one of the legs a body moisturizer with aloe vera was applied and on the other leg the cosmetic composition of the invention was applied, comprising Crotón lechle ⁇ and panthenol resin and, as additional active cosmetic ingredients, Rosehip oil, shea butter and aloe vera gel.
- Crotón lechle ⁇ and panthenol resin as additional active cosmetic ingredients, Rosehip oil, shea butter and aloe vera gel.
- the cosmetic composition of the invention constitutes an effective and safe response to the physical aggression produced by the laser on the skin, since among the effects it produces, the following can be highlighted: - it reduces inflammation and irritations,
- the object of the invention is also a method for reducing the effects of aggressions on the skin, which comprises applying a cosmetically effective amount of a composition of the invention to the skin.
- the application on the skin is a topical application, so that the composition is released locally in the area of the skin affected by the aggression.
- a cosmetically effective amount is that amount of composition of the invention that allows treating the entire affected area.
- the combination of the invention was subjected to an in vitro test to determine the antioxidant activity thereof.
- an in vitro test to determine the antioxidant activity thereof.
- physical-chemical methods can be used that assess the ability of a compound to sequester free radicals, also known as free radical scavenging activity.
- the assessed activity is independent of any enzymatic activity, as described in the article by Fauconneau et al., Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vin ⁇ fera cell cultures using in vitro tests, Life ScL , 1997, 61, 2103-21 10.
- DPPH 2,2-diphenyl-1-pyrillicrazil
- the antioxidant activity of the combination of the invention was compared with the activity of each component separately.
- the combination tested contained a panthenol: Croton lechler ⁇ resin ratio of 40: 1 expressed in weight: weight.
- Table 1 shows the EC 50 concentrations, which refer to the effective concentration of the compound necessary to capture 50% of the total amount of DPPH radicals, so that the lower the concentration, the greater the efficiency of the product :
- panthenol and Croton lechleri resin of the invention exhibits a synergistic anti-radical activity, since the EC 50 concentration of the combination is lower than the concentration for each of the components separately, and considerably less than corresponding value, taking into account that the combination includes 97.6% of panthenol and 2.4% of Croton lechleri resin.
- Example 1 Preparation of a body emulsion in the form of a cream containing the combination of Croton lechleri resin and panthenol of the invention
- the components of the hydrophilic phase were prepared in another stainless steel reactor equipped with a stirrer. For this, 50 kg of demineralized water, 3 kg of 99.5% glycerin were introduced into it, 2 kg of panthenol, and 2.5 kg of Cobiostab® 200 (phenoxyethanol), and the mass was heated to 80 ⁇ 2 0 C with stirring. At this temperature, the hydrophilic phase was incorporated on the lipophilic phase under stirring until an emulsion was achieved. Then, a cooling process was started at 35 ⁇ 2 0 C.
- Example 2 Preparation of a body emulsion in the form of cream with the combination of Croton lechleri resin and panthenol of the invention and extract of
- the components of the hydrophilic phase were prepared in a stainless steel reactor equipped with a stirrer. For this, 50 kg of demineralized water, 2 kg of 99.5% glycerin, 3 kg of hydroalcoholic extract of Centella asiatica, 2 kg of 3 panthenol were introduced therein.
- Cobiostab ® 200 phenoxyethanol
- Cobiostab ® 200 phenoxyethanol
- 1 kg of Simulgel ® NS mixture of squalane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide and hydroxyethyl acrylate copolymer and sodium acrylo dimethyl restaurant
- Simulgel ® NS mixture of squalane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide and hydroxyethyl acrylate copolymer and sodium acrylo dimethyl restaurant
- the lipophilic phase was incorporated into the reactor containing the other components and stirred until an emulsion was achieved. Under stirring, 0.5 kg of Plantactiv ® GLA 18 (glycyrrhetic acid) was then added, and cooling to 40 ⁇ 2 0 C was started. Once this temperature was reached, 3 kg of hydrochloric solution of resin were added.
- the antioxidant activity was determined by the in vitro assay described in the article by Brand-Williams et al., Use of a Free Radical Method to Evaluate Antioxidant Activity, Lebensm. Wiss Tecnol., 1995,
- the extract or the substance to be evaluated reacts with 1,1-diphenyl-2-picrylhydrazyl (DPPH) in an ethanolic solution.
- DPPH 1,1-diphenyl-2-picrylhydrazyl
- DPPH is a relatively stable organic free radical that, in an atom of the nitrogen bridge, shows an unpaired valence electron. It is reduced in the presence of antioxidant compounds, and this reduction is monitored by the decrease in the absorbance of this radical.
- the initial concentration of DPPH and the resulting concentration are determined once the possible antioxidant has been added, so that a decrease in radiation absorption It translates into a decrease in the concentration of DPPH due to the transfer of electrons.
- the results of the test are expressed as the EC 50 concentration, which is the concentration of the active ingredient necessary to bleach the DPPH by 50%, that is, to capture 50% of the total amount of DPPH radicals.
- the EC 50 concentration is the concentration of the active ingredient necessary to bleach the DPPH by 50%, that is, to capture 50% of the total amount of DPPH radicals.
- the EC 50 concentration is high, it means that the effective concentration needed for that compound to act as an antioxidant is higher.
- Vitamin E (( ⁇ ) - ⁇ -tocopherol, 1.1 units / mg) and vitamin C (L-ascorbic acid,> 99.0%) were used as a positive control.
- a solution of 0.1 mM DPPH (Sigma Chemical) in ethanol was prepared. From this solution five solutions were prepared at the concentrations 0.02 mM, 0.04 mM, 0.06 mM, 0.08 mM and 0.1 mM. The absorbance of these solutions was measured at a wavelength of 515 nm to obtain the calibration line. The DPPH solution in ethanol was taken as the blank of these samples. Then, concentrated solutions of the samples to be examined were prepared, with an approximate concentration of 10 g / l. 0.05 ml of said concentrated solutions were taken and given They added 2 ml of the 0.1 mM DPPH solution. In case the decrease in absorption is very rapid, an appropriate dissolution of the extract can be performed.
- the DPPH ethanolic solution was used as the target of these samples. After incubation for 30 minutes at 37 0 C, the reduction of DPPH radical was monitored in a spectrophotometer from the absorbance of the decrease of said radical at 515 nm. The percentage of DPPH discoloration was calculated according to the following expression: fAm— Abm ⁇
- Am Absorbance of the sample.
- the combination of the invention has an important free radical scavenging activity at an EC 50 concentration of 4.87 ⁇ g / ml, comparable to that of Vitamin C. Said concentration is lower than the EC 5O concentration of the resin.
- the combination of the tested invention contains a panthenol: resin ratio of 40: 1, which represents 97.6% by weight of panthenol and 2.4% by weight of Croton lechleri resin
- the expected value of The EC 5O concentration for said combination was 17.97 ⁇ g / ml (18.25 x 0.996 + 6.85 x 0.024).
- a synergistic effect regarding the antioxidant activity is thus observed when combining Crotón lechleri resin with panthenol.
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Abstract
The present invention relates to a novel combination of active cosmetic ingredients including resin from Croton lechleri and panthenol having antioxidant properties. Moreover it relates to cosmetic compositions including said combination and to the utilisation thereof to reduce the effects of irritant damage to the skin, in particular the effects of laser radiation thereon.
Description
COMBINACION DE INGREDIENTES ACTIVOS COSMÉTICOS Y COMPOSICIÓN COSMÉTICA OBTENIDA A PARTIR DE LA MISMA Y COMBINATION OF COSMETIC ACTIVE INGREDIENTS AND COSMETIC COMPOSITION OBTAINED FROM THE SAME AND
SU UTILIZACIÓN ITS USE
Campo de Ia técnica Field of the technique
La presente invención se refiere a una nueva combinación de ingredientes activos cosméticos con propiedades antioxidantes que se puede emplear para reducir los efectos de las agresiones irritantes a Ia piel. Estado de Ia técnica anterior The present invention relates to a new combination of cosmetic active ingredients with antioxidant properties that can be used to reduce the effects of irritating aggressions to the skin. State of the prior art
Los efectos sobre Ia piel de las agresiones producidas por el medio exterior (radiación solar, frío, agua, viento, etc.), así como debidas al paso del tiempo, producen cambios en Ia piel provocados por reacciones químicas oxidativas, las cuales generan un deterioro de sus propiedades, acelerando el proceso de envejecimiento. The effects on the skin of the aggressions produced by the external environment (solar radiation, cold, water, wind, etc.), as well as due to the passage of time, produce changes in the skin caused by oxidative chemical reactions, which generate a deterioration of its properties, accelerating the aging process.
Con el fin de minimizar los daños producidos tanto por Ia agresión medioambiental como por los efectos debidos al envejecimiento, se ha descrito Ia aplicación tópica de productos cosméticos que incluyen ingredientes activos de origen natural con propiedades antiinflamatorias o antioxidantes. In order to minimize the damage caused by both the environmental aggression and the effects due to aging, the topical application of cosmetic products that include active ingredients of natural origin with anti-inflammatory or antioxidant properties has been described.
En Ia solicitud de patente PCT WO-A-2004/103320 se describen composiciones tópicas para reducir los efectos del envejecimiento cronológico y del fotoenvejecimiento de Ia piel. Dichas composiciones incluyen, como componentes activos, un agonista de los receptores X del hígado (Liver-X-Receptor, LXR) y ácido retinoico o un precursor del mismo. Entre dichos agonistas se cita Ia resina de sangre de drago, procedente del árbol Daemorgos draco.
En Ia solicitud de patente PCT WO-A-2004/103376 se describen composiciones tópicas para aumentar Ia síntesis en Ia piel de decorina y fibronectina, proteínas del tejido conjuntivo, y, con ello, reducir los efectos del envejecimiento cronológico y del fotoenvejecimiento de Ia piel. Más en concreto, se describe una emulsión del tipo aceite en agua (O/W) que contiene resina de sangre de dragón procedente del árbol Daemonorops drago. In the PCT patent application WO-A-2004/103320 topical compositions are described to reduce the effects of chronological aging and skin photoaging. Such compositions include, as active components, an agonist of the liver X receptors (Liver-X-Receptor, LXR) and retinoic acid or a precursor thereof. Among these agonists, the resin of dragon blood, from the Daemorgos draco tree, is cited. In the PCT patent application WO-A-2004/103376 topical compositions are described to increase the synthesis in the skin of decorin and fibronectin, connective tissue proteins, and, thereby, reduce the effects of chronological aging and photoaging of Ia skin. More specifically, an oil-in-water (O / W) type emulsion containing dragon blood resin from the dragon tree Daemonorops tree is described.
En Ia patente norteamericana US 3809749 se describen composiciones farmacéuticas tópicas que incluyen extractos de C. lechlerí como ingrediente activo principal y que son apropiadas para el tratamiento de pequeños cortes, abrasiones y heridas en Ia piel. Dichas composiciones incluyen componentes cosméticos para Ia obtención de cremas, ungüentos, lociones, emulsiones del tipo agua en aceite (W/O), emulsiones del tipo aceite en agua (O/W). También se describen formulaciones que incluyen otros principios activos, por ejemplo antibióticos y anestésicos locales, para obtener efectos complementarios. In the US patent US 3809749 topical pharmaceutical compositions are described that include extracts of C. lechlerí as the main active ingredient and that are suitable for the treatment of small cuts, abrasions and wounds in the skin. Said compositions include cosmetic components for obtaining creams, ointments, lotions, emulsions of the water-in-oil type (W / O), emulsions of the oil-in-water type (O / W). Formulations that include other active ingredients, for example antibiotics and local anesthetics, are also described to obtain complementary effects.
La aplicación de radiación láser sobre Ia piel, tanto por motivos estéticos como terapéuticos, da lugar a distintos efectos secundarios y colaterales debidos esencialmente al calor acumulado sobre las células de Ia epidermis y Ia dermis, y a Ia respuesta inflamatoria reactiva frente aThe application of laser radiation on the skin, both for aesthetic and therapeutic reasons, results in different side and side effects due essentially to the heat accumulated on the cells of the epidermis and the dermis, and the reactive inflammatory response against
Ia agresión física que esta radiación luminosa induce en Ia zona de exposición. The physical aggression that this light radiation induces in the area of exposure.
Todo ello se traduce en una piel deshidratada, con soluciones de continuidad en su superficie, desestructurada, adelgazada y edematizada, que suele provocar en los pacientes una sensación de tirantez, prurito y escozor local, volviéndose más proclive a experimentar sobreinfecciones y posteriormente a Ia aparición de hiper o hipopigmentaciones postinflamatorias residuales, así como una piel donde remarcan las arrugas de expresión y las líneas de tensión.
Las composiciones cosméticas descritas en el estado de Ia técnica resultan poco apropiadas para aliviar los efectos producidos por Ia radiación láser en Ia piel. All this translates into a dehydrated skin, with solutions of continuity on its surface, unstructured, thinned and edematized, which usually causes patients to feel a sensation of tightness, itching and local stinging, becoming more likely to experience superinfections and subsequently to the appearance of hyper or residual post-inflammatory hypopigmentations, as well as a skin where expression wrinkles and tension lines stand out. The cosmetic compositions described in the state of the art are not very appropriate to alleviate the effects produced by the laser radiation on the skin.
Por tanto, sigue existiendo Ia necesidad de disponer de una composición cosmética apropiada para reducir las agresiones irritantes aTherefore, there is still a need for an appropriate cosmetic composition to reduce irritating aggressions to
Ia piel producidas cuando se aplica radiación láser con fines dermatológicos. The skin produced when laser radiation is applied for dermatological purposes.
Objeto de Ia invención Object of the invention
Un objeto de Ia invención es una combinación de ingredientes activos cosméticos. También es parte integrante de Ia invención una composición cosmética que incluye dicha combinación. An object of the invention is a combination of cosmetic active ingredients. Also an integral part of the invention is a cosmetic composition that includes said combination.
Otro objeto de Ia invención es Ia utilización de dicha combinación en Ia preparación de una composición cosmética para reducir los efectos de las agresiones a Ia piel. Es igualmente objeto de Ia invención Ia utilización de Ia composición cosmética obtenida a partir de Ia combinación de Ia invención para reducir los efectos de las agresiones a Ia piel. Another object of the invention is the use of said combination in the preparation of a cosmetic composition to reduce the effects of aggressions on the skin. It is also the object of the invention to use the cosmetic composition obtained from the combination of the invention to reduce the effects of aggressions on the skin.
Forma parte también del objeto de Ia invención un procedimiento para reducir los efectos de las agresiones a Ia piel, el cual comprende aplicar sobre Ia piel una cantidad cosméticamente efectiva de Ia composición o combinación de Ia invención. Also part of the object of the invention is a method for reducing the effects of aggressions on the skin, which comprises applying a cosmetically effective amount of the composition or combination of the invention on the skin.
Descripción detallada de Ia invención Detailed description of the invention
Los autores de Ia presente invención han descubierto ahora una combinación de ingredientes activos cosméticos con propiedades antioxidantes que sorprendentemente presenta un efecto sinérgico y que es apropiada para reducir las agresiones irritantes a Ia piel, en particular los efectos de Ia radiación láser.
- A - The authors of the present invention have now discovered a combination of cosmetic active ingredients with antioxidant properties that surprisingly have a synergistic effect and that is appropriate to reduce irritating aggressions to the skin, in particular the effects of laser radiation. - TO -
Por tanto, un objeto de Ia presente invención es una combinación de ingredientes activos cosméticos que comprende: a) resina de Crotón lechleή, y b) pantenol. La proporción entre Ia resina de Crotón lechlerí y el pantenol se encuentra comprendida entre 1 :500 y 1 :2, expresada en peso:peso, preferentemente entre 1 :200 y 1 :10, en especial entre 1 :100 y 1 :20, con especial preferencia entre 1 :50 y 1 :30 y en particular entre 1 :45 y 1 :35. En una forma de realización de Ia invención, Ia relación particularmente preferente es 1 :40. Therefore, an object of the present invention is a combination of active cosmetic ingredients comprising: a) Croton lechleή resin, and b) panthenol. The proportion between Crotón lechlerí resin and panthenol is between 1: 500 and 1: 2, expressed in weight: weight, preferably between 1: 200 and 1: 10, especially between 1: 100 and 1: 20, with special preference between 1: 50 and 1: 30 and in particular between 1: 45 and 1: 35. In an embodiment of the invention, the particularly preferred ratio is 1: 40.
En una realización preferente, Ia composición cosmética de Ia invención incluye una combinación de ingredientes activos que consiste esencialmente en resina de Crotón lechlerí y pantenol. In a preferred embodiment, the cosmetic composition of the invention includes a combination of active ingredients consisting essentially of Croton lechlerí resin and panthenol.
Resina de Crotón lechlerí Crotón lechlerí es el nombre científico del árbol denominadoCrotón lechlerí resin Crotón lechlerí is the scientific name of the tree called
"sangre de drago", perteneciente a Ia familia de las Euphorbiaceae. De dicho árbol se extrae una resina cuyos componentes más activos son proantocianidinas y el alcaloide taspina. Otros componentes de Ia resina son lignanos, ácidos grasos poliinsaturados, pigmentos y flavonoides. En el artículo de revisión de K. Jones, Review of Sangre de Drago"dragon blood", belonging to the family of the Euphorbiaceae. From this tree a resin is extracted whose most active components are proanthocyanidins and the taspin alkaloid. Other components of the resin are lignans, polyunsaturated fatty acids, pigments and flavonoids. In the review article by K. Jones, Review of Drago's Blood
(Crotón Lechlerí) - A South American Tree Sap in the Treatment of Diarrhea, Inflammation, Insect Bites, Viral Infections, and Wounds: Tradicional Uses to Clinical Research, J. Altern. Complem. Med., 2003, 9(6), 877-896, se describen las propiedades y aplicaciones tradicionales de Ia resina de C. lechlerí.
La resina de C. lechleri se puede encontrar comercialmente, por ejemplo en forma de solución hidroglicólica (agua y propilenglicol), bajo Ia denominación Dragon's Blood, de Ia compañía Cobiosa, estando el contenido en resina comprendido entre el 1% y el 5% en peso. Pantenol (Croton Lechlerí) - A South American Tree Sap in the Treatment of Diarrhea, Inflammation, Insect Bites, Viral Infections, and Wounds: Traditional Uses to Clinical Research, J. Altern. Complem Med., 2003, 9 (6), 877-896, describe the traditional properties and applications of C. lechlerí resin. The C. lechleri resin can be found commercially, for example in the form of a hydro-glycol solution (water and propylene glycol), under the name Dragon's Blood, from the Cobiosa company, the resin content being between 1% and 5% in weight. Panthenol
El pantenol es un compuesto que pertenece al grupo de Ia vitamina B y se transforma a ácido pantoténico (vitamina B5) en Ia piel, por ello también es denominado provitamina B5. Panthenol is a compound that belongs to the group of vitamin B and is transformed to pantothenic acid (vitamin B 5 ) in the skin, so it is also called provitamin B 5 .
Dicho compuesto es bien conocido en Ia industria cosmética, ya que se vienen empleando hace años como agente hidratante de Ia piel, presentando igualmente propiedades antiinflamatorias. Said compound is well known in the cosmetic industry, since it has been used for years as a skin moisturizing agent, also presenting anti-inflammatory properties.
El pantenol es un compuesto químico que tiene un átomo de carbono quiral, existiendo por ello en dor forma enantioméricas, de ellas solamente el D-pantenol (dexpantenol) es activo biológicamente. No obstante, ambos enantiómeros presentan actividad hidratante y en las composiciones cosméticas se puede emplear tanto el D-pantenol como Ia mezcla racémica que incluye D-pantenol y L-pantenol. Panthenol is a chemical compound that has a chiral carbon atom, therefore existing in the enantiomeric form, of which only D-panthenol (dexpanthenol) is biologically active. However, both enantiomers have moisturizing activity and both D-panthenol and the racemic mixture that includes D-panthenol and L-panthenol can be used in cosmetic compositions.
En Ia combinación de Ia invención, el pantenol se selecciona entre D-pantenol y Ia mezcla racémica, preferentemente se emplea D-pantenol. Composiciones In the combination of the invention, panthenol is selected from D-panthenol and the racemic mixture, preferably D-panthenol is used. Compositions
También es objeto de Ia invención una composición cosmética que comprende Ia combinación de Ia invención y un vehículo cosméticamente aceptable. Also object of the invention is a cosmetic composition comprising the combination of the invention and a cosmetically acceptable vehicle.
La combinación de Ia invención se puede formular en forma de composiciones cosméticas para facilitar su aplicación. The combination of the invention can be formulated in the form of cosmetic compositions to facilitate its application.
En general, tales composiciones cosméticas contienen:
- entre un 1 % y un 20% en peso de Ia combinación de Ia invención, y In general, such cosmetic compositions contain: - between 1% and 20% by weight of the combination of the invention, and
- entre un 80% y un 99% en peso de un vehículo cosméticamente aceptable, ajustándose los porcentajes de los componentes de modo que el balance sea del 100%. - between 80% and 99% by weight of a cosmetically acceptable vehicle, adjusting the percentages of the components so that the balance is 100%.
Las composiciones de Ia invención contienen preferentemente entre un 1 ,5% y un 10% en peso de Ia combinación de Ia invención, en especial entre un 2% y un 8% en peso y con especial preferencia entre un 4% y un 6% en peso de Ia combinación de invención. En una realización preferente, Ia composición de Ia invención contiene entre el 1 % y el 5% en peso, en especial entre el 2% y el 4% en peso y en particular entre el 2,5% y el 3,5% en peso de una combinación de resina de Crotón lechleri y pantenol que contiene entre el 1 % y el 5% en peso de resina y entre el 0,5% y el 5% en peso, en especial entre el 1 % y el 4% en peso y en particular entre el 1 ,5% y el 3% en peso de pantenol. The compositions of the invention preferably contain between 1.5% and 10% by weight of the combination of the invention, especially between 2% and 8% by weight and especially preferably between 4% and 6% by weight of the combination of invention. In a preferred embodiment, the composition of the invention contains between 1% and 5% by weight, especially between 2% and 4% by weight and in particular between 2.5% and 3.5% by weight. weight of a combination of Croton lechleri and panthenol resin containing between 1% and 5% by weight of resin and between 0.5% and 5% by weight, especially between 1% and 4% in weight and in particular between 1.5% and 3% by weight of panthenol.
En una realización especialmente preferente de Ia composición de Ia invención, ésta contiene un 3% en peso de una combinación de resina de Crotón lechleri y pantenol que contiene entre un 1 ,5% y un 1 ,75% en peso de resina y un 2% en peso de pantenol, en especial un 3% en peso de una combinación de Crotón lechleri y pantenol que contiene entre un 1 ,5% y un 1 ,75% en peso de resina y un 2% en peso de D-pantenol. In a particularly preferred embodiment of the composition of the invention, it contains 3% by weight of a combination of Croton lechleri and panthenol resin containing between 1.5% and 1.75% by weight of resin and 2 % by weight of panthenol, especially 3% by weight of a combination of Croton lechleri and panthenol containing between 1.5% and 1.75% by weight of resin and 2% by weight of D-panthenol.
Las composiciones de Ia invención incluyen un vehículo cosméticamente aceptable en el cual se encuentran disueltos, emulsionados, dispersados o suspendidos los ingredientes cosméticos.The compositions of the invention include a cosmetically acceptable vehicle in which the cosmetic ingredients are dissolved, emulsified, dispersed or suspended.
Dicho vehículo se selecciona entre agua, un vehículo no acuoso miscible en agua, por ejemplo etanol, isopropanol, y un vehículo no acuoso no
miscible en agua, por ejemplo aceite de parafina. Preferentemente las composiciones de Ia invención incluyen agua como vehículo. Said vehicle is selected from water, a water miscible non-aqueous vehicle, for example ethanol, isopropanol, and a non-aqueous non-aqueous vehicle Water miscible, for example paraffin oil. Preferably the compositions of the invention include water as a vehicle.
Preferentemente, las composiciones cosméticas de Ia invención contienen, además de Ia combinación de Ia invención, al menos un ingrediente cosmético adicional, por ejemplo ingredientes activos cosméticos, productos auxiliares y aditivos adicionales, los cuales se pueden seleccionar de entre el grupo formado por agentes tensioactivos y emulsionantes, compuestos lipidíeos y emolientes, factores de consistencia y agentes espesantes, estabilizantes, hidrótropos, agentes conservantes, esencias, colorantes y mezclas de los mismos. También pueden incluir otros componentes tales como compuestos de silicona, grasas, ceras, lecitinas, fosfolípidos, factores de protección solar UV, fumógenos, autobronceadores o inhibidores de tirosina (agentes de despigmentación). Preferentemente, las composiciones cosméticas de Ia invención contienen, además de Ia combinación de Ia invención, un ingrediente cosmético adicional seleccionado de entre el grupo formado por agentes tensioactivos y emulsionantes, compuestos lipidíeos y emolientes, factores de consistencia y agentes espesantes, hidrótropos, agentes conservantes y mezclas de los mismos. Preferably, the cosmetic compositions of the invention contain, in addition to the combination of the invention, at least one additional cosmetic ingredient, for example cosmetic active ingredients, auxiliary products and additional additives, which can be selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickeners, stabilizers, hydrotropes, preservatives, essences, dyes and mixtures thereof. They may also include other components such as silicone compounds, fats, waxes, lecithins, phospholipids, UV sun protection factors, smokers, self tanners or tyrosine inhibitors (depigmentation agents). Preferably, the cosmetic compositions of the invention contain, in addition to the combination of the invention, an additional cosmetic ingredient selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickening agents, hydrotropes, preservatives and mixtures thereof.
La composición obtenida a partir de Ia combinación de ingredientes de Ia presente invención se puede administrar en diversas presentaciones cosméticas, preferentemente éstas se encuentran en forma de cremas, lociones, leches y emulsiones pulverizables. Tales composiciones contienen agua y una fase lipófila y se presentan generalmente en forma de emulsiones o dispersiones, por ejemplo del tipo aceite en agua (ONSI), agua en aceite QNIO), emulsiones múltiples (W/O/W) o emulsiones del tipo PIT, según se describe en Ia patente española ES 2169908-T3, o como microemulsiones.
Preferentemente se encuentran en forma de emulsión del tipo aceite en agua (O/W). The composition obtained from the combination of ingredients of the present invention can be administered in various cosmetic presentations, preferably these are in the form of sprayable creams, lotions, milks and emulsions. Such compositions contain water and a lipophilic phase and are generally in the form of emulsions or dispersions, for example of the oil-in-water type (ONSI), water in oil QNIO), multiple emulsions (W / O / W) or emulsions of the PIT type , as described in Spanish patent ES 2169908-T3, or as microemulsions. They are preferably in the form of an emulsion of the oil-in-water (O / W) type.
En una realización preferente, las composiciones cosméticas de Ia invención contienen: - entre un 1 % y un 10% en peso de Ia combinación de Ia invención, In a preferred embodiment, the cosmetic compositions of the invention contain: between 1% and 10% by weight of the combination of the invention,
- entre un 5% y un 50% en peso de al menos un ingrediente cosmético adicional, y - between 5% and 50% by weight of at least one additional cosmetic ingredient, and
- entre un 40% y un 94% en peso de un vehículo cosméticamente aceptable, ajustándose los porcentajes de los componentes de modo que el balance sea del 100%. - between 40% and 94% by weight of a cosmetically acceptable vehicle, adjusting the percentages of the components so that the balance is 100%.
En esta realización preferente, el contenido de ingrediente cosmético adicional presente en Ia composición cosmética de Ia invención está comprendido entre el 10% y el 45% en peso, en especial entre el 15% y el 35% en peso y en particular entre el 20% y el 25% en peso, con respecto a Ia composición total. In this preferred embodiment, the content of additional cosmetic ingredient present in the cosmetic composition of the invention is between 10% and 45% by weight, especially between 15% and 35% by weight and in particular between 20 % and 25% by weight, with respect to the total composition.
En esta realización preferente, el contenido de vehículo presente en Ia composición cosmética de Ia invención está comprendido entre elIn this preferred embodiment, the content of the vehicle present in the cosmetic composition of the invention is comprised between the
50% y el 90% en peso, en especial entre el« 55% y el 87% en peso y en particular entre el 65% y el 85% en peso, con respecto a Ia composición total. 50% and 90% by weight, especially between «55% and 87% by weight and in particular between 65% and 85% by weight, with respect to the total composition.
Ingredientes activos cosméticos adicionales Additional cosmetic active ingredients
En una realización preferente, Ia composición de Ia invención incluye además un ingrediente activo cosmético seleccionado de entre el grupo consistente en: extracto de Centella asiática, gel de aloe vera,
aceite de Rosa mosqueta, aceite de almendras dulces, manteca de karité, ácido glicirrético, vitamina E y sus derivados, y mezclas de los mismos. In a preferred embodiment, the composition of the invention also includes a cosmetic active ingredient selected from the group consisting of: Centella asiatica extract, aloe vera gel, Rosehip oil, sweet almond oil, shea butter, glycyrrhetic acid, vitamin E and its derivatives, and mixtures thereof.
La Centella asiática es una pequeña planta anual trepadora de Ia familia de las Apiaceae, que crece en zonas tropicales. También es conocida por Gotu Kola. Los componentes principales de dicha planta son derivados triterpénicos, abundantes taninos, aceite esencial, fitosteroles y mucílagos. Se emplea tradicionalmente por su poder cicatrizante y relajante, ya que favorece Ia síntesis de colágeno. En general, el extracto de Centella asiática se comercializa como extracto hidroglicólico (agua y propilenglicol), por ejemplo a través de Ia compañía Provital, y tiene un residuo seco comprendido entre el 2,5% y el 3,5% en peso. Centella asiatica is a small annual climbing plant of the Apiaceae family, which grows in tropical areas. It is also known by Gotu Kola. The main components of this plant are triterpenic derivatives, abundant tannins, essential oil, phytosterols and mucilages. It is traditionally used for its healing and relaxing power, since it favors the synthesis of collagen. In general, Centella asiatica extract is marketed as a hydro-glycolic extract (water and propylene glycol), for example through the Provital company, and has a dry residue comprised between 2.5% and 3.5% by weight.
En Ia composición de Ia invención, el contenido de extracto de Centella asiática oscila entre el 1% y el 5% en peso, preferentemente entre el 2% y el 4% en peso, en especial entre el 2,5% y el 3,5% en peso. El gel de aloe vera se obtiene de Ia planta suculenta Aloe barbadensis de Ia familia Asphodelaceae. Las hojas de dicha planta están compuestas de tres capas: una protección coriácea exterior, una capa fibrosa debajo de ésta y un corazón gelatinoso donde almacena sus reservas de agua y con el que se preparan productos farmacéuticos y cosméticos. El uso del gel de aloe vera para el tratamiento de afecciones cutáneas se encuentra notablemente extendido. En el mercado se puede encontrar el gel de aloe vera extraído de Ia planta con un contenido en sólidos de aproximadamente el 0,5% en peso, y que se denomina gel 1 :1. También se puede encontrar en forma de gel concentrado al que se Ie ha extraído una parte del agua. Por ejemplo, el gel concentrado 2:1 tiene contenido en sólidos de aproximadamente el 1% en peso; el gel concentrado 10:1 tiene un contenido en sólidos de aproximadamente el 5% en peso; el gel concentrado 40:1 tiene un contenido en sólidos de aproximadamente el 20% en peso. También se encuentran productos
atomizados 100:1 y 200:1 , que permiten reconstituir el gel original al mezclar una parte del mismo y 99 partes de agua o 1 parte y 199 partes de agua respectivamente. In the composition of the invention, the content of extract of Centella asiatica ranges between 1% and 5% by weight, preferably between 2% and 4% by weight, especially between 2.5% and 3, 5% by weight. Aloe vera gel is obtained from the succulent Aloe barbadensis plant of the Asphodelaceae family. The leaves of this plant are composed of three layers: an outer leathery protection, a fibrous layer under it and a jelly-like heart where it stores its water reserves and with which pharmaceutical and cosmetic products are prepared. The use of aloe vera gel for the treatment of skin conditions is remarkably widespread. In the market you can find the aloe vera gel extracted from the plant with a solids content of approximately 0.5% by weight, and which is called 1: 1 gel. It can also be found in the form of a concentrated gel to which part of the water has been extracted. For example, the 2: 1 concentrated gel has solids content of about 1% by weight; the 10: 1 concentrated gel has a solids content of about 5% by weight; The 40: 1 concentrated gel has a solids content of approximately 20% by weight. Products are also found sprayed 100: 1 and 200: 1, which allow the original gel to be reconstituted by mixing a part of it and 99 parts of water or 1 part and 199 parts of water respectively.
En Ia composición de Ia invención preferentemente se emplea un gel de aloe vera concentrado 10:1 , de manera que Ia combinación de 1 parte de dicho gel con 9 partes de agua conduce al gel original de Ia planta. In the composition of the invention preferably a 10: 1 concentrated aloe vera gel is used, so that the combination of 1 part of said gel with 9 parts of water leads to the original gel of the plant.
En Ia composición de Ia invención, el contenido de gel de aloe vera concentrado 10:1 oscila entre el 0,5% y el 10% en peso, preferentemente entre el 1% y el 8% en peso, en especial entre el 2% y el 5% y en particular entre el 2,5% y el 4%. In the composition of the invention, the 10: 1 concentrated aloe vera gel content ranges between 0.5% and 10% by weight, preferably between 1% and 8% by weight, especially between 2% and 5% and in particular between 2.5% and 4%.
La Rosa mosqueta es una planta perteneciente a Ia familia Rosaceae, que engloba a tres especies: Rosa moschata, Rosa canina y Rosa rubiginosa. Es un arbusto de ramas delgadas, flexibles y muy espinosas, que puede sobrepasar los 2 metros de altura. En Ia actualidad se encuentra extendida por diversas zonas del planeta, en especial en regiones de clima templado. El aceite se extrae de las semillas que contienen sus frutos. Dicho aceite se emplea en Ia industria cosmética debido a los efectos beneficiosos que produce en Ia piel, por ejemplo hidratación de pieles envejecidas, prevención de estrías, y también en el tratamiento de cicatrices, quemaduras, melanomas, dermatitis y psoriasis. Rosa mosqueta is a plant belonging to the Rosaceae family, which includes three species: Rosa moschata, Rosa canina and Rosa rubiginosa. It is a shrub with thin, flexible and very thorny branches, which can exceed 2 meters high. At present it is extended by various areas of the planet, especially in temperate regions. The oil is extracted from the seeds that contain its fruits. Said oil is used in the cosmetic industry due to the beneficial effects it produces on the skin, for example hydration of aged skin, prevention of stretch marks, and also in the treatment of scars, burns, melanomas, dermatitis and psoriasis.
En Ia composición de Ia invención, el contenido de aceite de Rosa mosqueta oscila entre el 0,1 % y el 5% en peso, preferentemente entre el 0,2% y el 3% en peso, en especial entre el 0,3% y el 1 % en peso y en particular entre el 0,4% y el 0,6% en peso. In the composition of the invention, the content of Rosehip oil ranges between 0.1% and 5% by weight, preferably between 0.2% and 3% by weight, especially between 0.3% and 1% by weight and in particular between 0.4% and 0.6% by weight.
El aceite de almendras dulce se obtiene del fruto del árbol del almendro (Prunus dulcís), de Ia familia de las Rosaceae, que tiene su origen en las regiones de Asia Central. El aceite de almendras dulces se
puede obtener mediante Ia técnica de prensado en frío, y el producto así obtenido puede retinarse adicionalmente para reducir Ia intensidad del aroma, si bien en dicho proceso de refino se pierden también algunas de sus propiedades. Dicho aceite se emplea en cosmética por sus propiedades emolientes, suavizantes, hidratantes y desinflamantes. Sweet almond oil is obtained from the fruit of the almond tree (Prunus dulcís), from the Rosaceae family, which has its origin in the regions of Central Asia. Sweet almond oil gets it can be obtained by means of the cold pressing technique, and the product thus obtained can be further retined to reduce the intensity of the aroma, although some of its properties are also lost in said refining process. Said oil is used in cosmetics for its emollient, softening, moisturizing and anti-inflammatory properties.
En Ia composición de Ia invención, el contenido de aceite de almendras dulces oscila entre el 1 % y el 15% en peso, preferentemente entre el 2% y el 10% en peso, en especial entre el 3% y el 8% en peso y en particular entre el 4% y el 7% en peso. La manteca de karité se obtiene de las semillas del fruto delIn the composition of the invention, the sweet almond oil content ranges between 1% and 15% by weight, preferably between 2% and 10% by weight, especially between 3% and 8% by weight. and in particular between 4% and 7% by weight. Shea butter is obtained from the seeds of the fruit of
Butyrospermum parkii, árbol que crece en forma salvaje en una amplia zona del centro de África. Su composición es muy compleja, y se pueden identificar los ácidos palmítico, esteárico, oleico, linoleico, así como una fracción insaponificable que Ie confiere una gran capacidad hidratante y emoliente. Butyrospermum parkii, a tree that grows wild in a wide area of central Africa. Its composition is very complex, and palmitic, stearic, oleic, linoleic acids can be identified, as well as an unsaponifiable fraction that confers a great moisturizing and emollient capacity.
En Ia composición de Ia invención, el contenido de manteca de karité oscilao entre el 0,5% y el 5% en peso, preferentemente entre el 1 % y el 4% en peso y en especial entre el 1 ,5% y el 3% en peso. In the composition of the invention, the content of shea butter ranges between 0.5% and 5% by weight, preferably between 1% and 4% by weight and especially between 1.5% and 3 % in weigh.
El ácido glicirrético o glicirretínico se obtiene, por hidrólisis del ácido glicirrícico, que a su vez se extrae de Ia raíz del regaliz (Glycyrrhiza glabra). El ácido glicirrético posee propiedades calmantes, antiinflamatorias y cicatrizantes y, por ello, se emplea en cosmética para proteger Ia piel ante las agresiones externas. Glycyrrhizinic acid or glycyrrhizinic acid is obtained by hydrolysis of glycyrrhizic acid, which in turn is extracted from licorice root (Glycyrrhiza glabra). Glycyrrhetic acid has soothing, anti-inflammatory and healing properties and, therefore, is used in cosmetics to protect the skin from external aggressions.
En Ia composición de Ia invención, el contenido de ácido glicirrético oscila entre el 0,1 % y el 3% en peso, preferentemente entre el 0,2% y elIn the composition of the invention, the glycyrrhetic acid content ranges between 0.1% and 3% by weight, preferably between 0.2% and
2% en peso y en especial entre el 0,4% y el 1 % en peso.
La vitamina E o α-tocoferol es una vitamina liposoluble que actúa como antioxidante. Se encuentra en muchos alimentos, principalmente de origen vegetal, sobre todo en los de hoja verde, semillas, entre ellos el brócoli, las espinacas, Ia soja, el germen de trigo y Ia levadura de cerveza; también puede encontrarse en alimentos de origen animal como Ia yema de huevo. Comercialmente Ia vitamina E se puede encontrar también en forma de éster con ácido acético, como en el acetato de α-tocoferol. Dicho compuesto es menos ácido y es el derivado de Ia vitamina E que se emplea habitualmente en composiciones cosméticas. Preferentemente, en Ia composición de Ia invención se emplea acetato de α-tocoferol y su contenido oscila entre el 0,05% y el 2% en peso, en especial entre el 0,1% y el 1% en peso y en particular entre el 0,15% y el 0,5% en peso. 2% by weight and especially between 0.4% and 1% by weight. Vitamin E or α-tocopherol is a fat-soluble vitamin that acts as an antioxidant. It is found in many foods, mainly of plant origin, especially those with green leaves, seeds, including broccoli, spinach, soybeans, wheat germ and brewer's yeast; It can also be found in foods of animal origin such as egg yolk. Commercially, vitamin E can also be found in the form of an ester with acetic acid, as in α-tocopherol acetate. Said compound is less acidic and is the derivative of vitamin E that is commonly used in cosmetic compositions. Preferably, in the composition of the invention α-tocopherol acetate is used and its content ranges between 0.05% and 2% by weight, especially between 0.1% and 1% by weight and in particular between 0.15% and 0.5% by weight.
Agentes tensioactivos y emulsionantes Las composiciones de Ia invención pueden incluir adicionalmente agentes tensioactivos para facilitar Ia solución, emulsión, dispersión o suspensión de los componentes cosméticos. Surfactants and emulsifiers The compositions of the invention may additionally include surfactants to facilitate the solution, emulsion, dispersion or suspension of cosmetic components.
Los tensioactivos pueden ser aniónicos, no iónicos, catiónicos y/o anfóteros. Preferentemente se emplean tensioactivos no iónicos. El contenido de agentes tensioactivos se encuentra comprendido entre el 1 % y el 30% en peso, preferentemente entre el 2% y el 20%, en especial entre el 3% y el 10% y en particular entre el 4% y el 8%. The surfactants can be anionic, nonionic, cationic and / or amphoteric. Preferably nonionic surfactants are used. The content of surfactants is between 1% and 30% by weight, preferably between 2% and 20%, especially between 3% and 10% and in particular between 4% and 8% .
Ejemplos típicos de agentes tensioactivos aniónicos son, por citar algunos, jabones, aléanos sulfonados, olefinas sulfonadas, sulfates de alquilo, etersulfatos de alcoholes grasos, etersulfatos de glicerina, etersulfatos de ácidos grasos, sulfosuccinatos de mono- y dialquilo, sulfosuccinamatos de mono- y dialquilo, ácidos etercarboxílicos y sus
sales, isetionatos de ácidos grasos, sarcosinatos de ácidos grasos, tauridas de ácidos grasos, N-ac¡laminoácidos. Ejemplos típicos de agentes tensioactivos no iónicos son, entre otros, alcoholes grasos polialcoxilados, ácidos grasos polialcoxilados, amidas de ácidos grasos polialcoxiladas, aminas grasas polialcoxiladas, triglicéridos alcoxilados, éteres mixtos, alquilpoliglicósidos, N-alquilglucamidas de ácidos grasos, esteres de sorbitán, esteres de sorbitán polietoxilados y óxidos de amina. Ejemplos típicos de agentes tensioactivos catiónicos son, entre otros, compuestos de amonio cuaternario y sales cuaternizadas de esteres de trialcanolaminas y ácidos grasos, por ejemplo Esterquats. Ejemplos típicos de agentes tensioactivos anfóteros son, entre otros, alquilbetaínas, alquilamidobetaínas, aminopropionatos, aminoglicinatos, betaínas de imidazolinio y sulfobetaínas. Typical examples of anionic surfactants are, to name a few, soaps, sulphonated alloys, sulphonated olefins, alkyl sulfates, fatty alcohol ether sulfates, glycerin ether sulfates, fatty acid ether sulfates, mono- and dialkyl sulfosuccinates, mono- and sulfosuccinamates dialkyl, ethercarboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acylamino acids. Typical examples of non-ionic surfactants are, among others, polyalkoxylated fatty alcohols, polyalkoxylated fatty acids, polyalkoxylated fatty acid amides, polyalkoxylated fatty amines, alkoxylated triglycerides, mixed ethers, alkyl polyglycosides, fatty acid N-alkyl glucamides, esters, esters, esters of polyethoxylated sorbitan and amine oxides. Typical examples of cationic surfactants are, among others, quaternary ammonium compounds and quaternized salts of trialkanolamine esters and fatty acids, for example Esterquats. Typical examples of amphoteric surfactants are, among others, alkyl betaines, alkylamido betaines, aminopropionates, aminoglycinates, imidazolinium betaines and sulfobetaines.
En el caso de los citados agentes tensioactivos se trata exclusivamente de compuestos conocidos, cuya estructura y obtención son bien conocidos por el experto en Ia materia, y se pueden encontrar por ejemplo en el libro de X. Domingo, A guide to the surfactants world,In the case of said surfactants, these are exclusively known compounds, whose structure and production are well known to those skilled in the art, and can be found, for example, in the book of X. Sunday, A guide to the surfactants world,
Edicions Proa, Barcelona, 1995. Edicions Proa, Barcelona, 1995.
En las composiciones de Ia invención son especialmente preferentes los alquilpoliglicósidos, en especial el glucósido de cetearilo y en particular una combinación de éste con alcohol cetearílico (por ejemplo el producto MONTANOV® 68, de Ia compañía Seppic, o el productoIn the compositions of the invention, alkyl polyglycosides are especially preferred, especially cetearyl glycoside and in particular a combination thereof with cetearyl alcohol (for example the product MONTANOV ® 68, from the Seppic company, or the product
Emulgade® PL 68/50); o glucósido de miristilo, preferentemente en combinación con alcohol mirístico (por ejemplo el producto MONTANOV® 14 de Ia compañía Seppic). Emulgade ® PL 68/50); or myristyl glycoside, preferably in combination with myristic alcohol (for example the product MONTANOV ® 14 from the Seppic company).
Compuestos lipidíeos y emolientes Lipid compounds and emollients
Las composiciones de Ia invención pueden contener adicionalmente diversos compuestos lipidíeos y emolientes adicionales
que contribuyen a optimizar sus propiedades organolépticas y dermatológicas. The compositions of the invention may additionally contain various lipid compounds and additional emollients that contribute to optimize its organoleptic and dermatological properties.
La cantidad total de compuestos lipidíeos y emolientes adicionalmente presentes en Ia composición de Ia invención está comprendida entre un 1 y un 50% en peso, preferentemente entre un 5 y un 25% en peso y en especial entre un 5 y un 15% en peso. The total amount of lipid compounds and emollients additionally present in the composition of the invention is between 1 and 50% by weight, preferably between 5 and 25% by weight and especially between 5 and 15% by weight .
Como compuestos lipidíeos entran en consideración alcoholes de Guerbet a base de alcoholes grasos con 6 a 18 átomos de carbono, preferentemente con 8 a 10 átomos de carbono (por ejemplo el producto Eutanol® G de Ia compañía Cognis), esteres de ácidos grasos lineales conThe lipid compounds include Guerbet alcohols based on fatty alcohols with 6 to 18 carbon atoms, preferably with 8 to 10 carbon atoms (for example, the Eutanol ® G product of the Cognis company), esters of linear fatty acids with
6 a 22 átomos de carbono con alcoholes lineales con 6 a 22 átomos de carbono, esteres de ácidos carboxílicos ramificados con 6 a 13 átomos de carbono con alcoholes lineales con 6 a 22 átomos de carbono, por ejemplo miristato de miristilo, palmitato de miristilo, estearato de miristilo, estearato de behenilo, isoestearato de behenilo, oleato de behenilo, behenato de behenilo, erucato de behenilo o miristato de erucilo. 6 to 22 carbon atoms with linear alcohols with 6 to 22 carbon atoms, esters of branched carboxylic acids with 6 to 13 carbon atoms with linear alcohols with 6 to 22 carbon atoms, for example myristyl myristate, myristyl palmitate, Myristyl stearate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate or erucilo myristate.
Además, son apropiados esteres de ácidos grasos lineales con 6 a 22 átomos de carbono con alcoholes ramificados, en especial 2- etilhexanol (por ejemplo el producto Cetiol® 868 de Ia compañía Cognis); esteres de ácidos alquilhídroxicarboxílicos de 18 a 38 átomos de carbono con alcoholes grasos con 6 a 22 átomos de carbono lineales o ramificados, en especial malatos de dioctilo; esteres de ácidos grasos lineales y/o ramificados con alcoholes polivalentes -y/o alcoholes de Guerbet; triglicéridos a base de ácidos grasos con 6 a 10 átomos de carbono (por ejemplo el producto Mirytol 318® de Ia compañía Cognis); mezclas líquidas de mono/di/triglicéridos a base de ácidos grasos con 6 a 18 átomos de carbono; esteres de alcoholes grasos con 6 a 22 átomos de carbono y/o alcoholes de Guerbet con ácidos carboxílicos aromáticos, en especial ácido benzoico; esteres de ácidos d ¡carboxílicos con 2 a 12
átomos de carbono con alcoholes lineales o ramificados con 1 a 22 átomos de carbono, o polioles con 2 a 10 átomos de carbono y 2 a 6 grupos hidroxilo; aceites vegetales; alcoholes primarios ramificados; ciclohexanos sustituidos; carbonatos de alcoholes grasos con 6 a 22 átomos de carbono lineales y ramificados, por ejemplo carbonatos de dicaprililo (por ejemplo el producto Cetiol® CC de Ia compañía Cognis); dialquiléteres lineales o ramificados, simétricos o asimétricos, con 6 a 22 átomos de carbono por grupo alquilo, por ejemplo dicaprililéteres (por ejemplo el producto Cetiol® OE de Ia compañía Cognis); hidrocarburos alifáticos o bien nafténicos, por ejemplo escualano, escualeno o dialquilciclohexanos, y mezclas de los mismos. In addition, esters of linear fatty acids with 6 to 22 carbon atoms with branched alcohols are suitable, especially 2- ethylhexanol (for example, the product Cetiol ® 868 from the Cognis company); esters of alkyl hydroxycarboxylic acids of 18 to 38 carbon atoms with fatty alcohols with 6 to 22 linear or branched carbon atoms, especially dioctyl malate; esters of linear and / or branched fatty acids with polyhydric alcohols - and / or Guerbet alcohols; triglycerides based on fatty acids with 6 to 10 carbon atoms (for example the product Mirytol 318 ® from the Cognis company); liquid mixtures of mono / di / triglycerides based on fatty acids with 6 to 18 carbon atoms; esters of fatty alcohols with 6 to 22 carbon atoms and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid; esters of carboxylic acids with 2 to 12 carbon atoms with linear or branched alcohols with 1 to 22 carbon atoms, or polyols with 2 to 10 carbon atoms and 2 to 6 hydroxyl groups; vegetable oils; branched primary alcohols; substituted cyclohexanes; carbonates of fatty alcohols with 6 to 22 linear and branched carbon atoms, for example dicaprilyl carbonates (for example the Cetiol ® CC product of the Cognis company); linear or branched dialkyl ethers, symmetric or asymmetric, with 6 to 22 carbon atoms per alkyl group, for example dicaprilyl ethers (for example the Cetiol ® OE product of the Cognis company); aliphatic or naphthenic hydrocarbons, for example squalene, squalene or dialkylcyclohexanes, and mixtures thereof.
Para las composiciones de Ia invención son especialmente preferentes los productos Eutanol® G (alcohol Guerbet: octildodecanol),Especially preferred for the compositions of the invention are Eutanol ® G products (Guerbet alcohol: octyldodecanol),
Cetiol® 868 (estearato de 2-etilhexanol), Cetiol® CC (carbonato de dicaprililo) y Mirytol 318® (triglicéridos caprílicos y cápricos) de Ia compañía Cognis, y combinaciones de los mismos. Cetiol ® 868 (2-ethylhexanol stearate), Cetiol ® CC (dicaprilyl carbonate) and Mirytol 318 ® (caprylic and capric triglycerides) from the Cognis company, and combinations thereof.
Factores de consistencia y agentes espesantes Consistency factors and thickening agents
En las composiciones de Ia invención se emplean factores de consistencia y espesantes para ajustar Ia viscosidad y el comportamiento reológico de las mismas. In the compositions of the invention, consistency factors and thickeners are used to adjust the viscosity and the rheological behavior thereof.
Entre los factores de consistencia entran en consideración, en primer término, alcoholes grasos con una cadena de 12 a 22 átomos de carbono, y preferentemente de 16 a 18 átomos de carbono, y además glicéridos parciales, ácidos grasos o ácidos grasos hidroxilados. Agentes espesantes apropiados son, a modo de ejemplo, anhídrido silícico hidrófilo (por ejemplo los productos Aerosil® de Ia compañía Evonik); polisacáridos, en especial goma xantana, goma guar, agar-agar, alginatos y tilosas, carboximetilcelulosa e hidroxietilcelulosa, además de polietilenglicolmono- y diésteres de ácidos grasos de peso molecular más
elevado; poliacrilatos (por ejemplo Carbopol® y tipos de Pemulen® de Ia compañía Goodrich; Synthalene® de Ia compañía Sigma, tipos de Keltrol® de Ia compañía Kelgo; tipos de Sepigel® y Simulgel® de Ia compañía Seppic; tipos de Saleare® de Ia compañía Allied Colloids), poliacrilamidas, alcohol polivinílico y polivinilpirrolidona. Consistency factors include, in the first place, fatty alcohols with a chain of 12 to 22 carbon atoms, and preferably 16 to 18 carbon atoms, and also partial glycerides, fatty acids or hydroxylated fatty acids. Suitable thickening agents are, by way of example, hydrophilic silicic anhydride (for example, Aerosil ® products of the Evonik company); polysaccharides, especially xanthan gum, guar gum, agar-agar, alginates and tyloses, carboxymethylcellulose and hydroxyethylcellulose, in addition to polyethylene glycolmono- and diesters of molecular weight fatty acids plus high; polyacrylates (for example Carbopol ® and Pemulen grades ® of Goodrich company Ia, Ia Synthalens.RTM company Sigma, Keltrol ® types of Ia company Kelgo; Sepigel grades and Simulgel ® ® of Ia SEPPIC; Saleare ® types of Ia Allied Colloids), polyacrylamides, polyvinyl alcohol and polyvinylpyrrolidone.
Para conferir consistencia a las composiciones de Ia invención son especialmente adecuados alcohol cetílico, alcohol mirístico, el producto Simulgel® EG de Ia compañía Seppic (mezcla de isohexadecano, monooleato de sorbitán etoxilado con 20 moles de óxido de etileno, y copolímero de acrilato de hidroxietilo y acriloildimetiltaurato sódico),To give consistency to the compositions of the invention, cetyl alcohol, myristic alcohol, the Simulgel ® EG product of the Seppic company (mixture of isohexadecane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide, and hydroxyethyl acrylate copolymer) are especially suitable and sodium acryloyl dimethyl restaurant),
Simulgel® NS de Ia compañía Seppic (mezcla de escualano, monooleato de sorbitán etoxilado con 20 moles de óxido de etileno, y copolímero de acrilato de hidroxietilo y acroloildimetiltaurato sódico) y mezclas de los mismos. Hidrótropos Simulgel ® NS from the Seppic company (mixture of squalane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide, and copolymer of hydroxyethyl acrylate and sodium acrylo dimethyl restaurant) and mixtures thereof. Hydrotropes
Para mejorar Ia fluidez de las composiciones de Ia invención se pueden emplear además hidrótropos, por ejemplo etanol, alcohol isopropílico o polioles. Los polioles que entran en consideración en este caso preferentemente tienen de 2 a 15 átomos de carbono y al menos dos grupos hidroxilo. Los polioles pueden contener además otros grupos funcionales, en especial grupos amino, o bien estar modificados con nitrógeno. Son ejemplos típicos glicerina; alquilenglicoles, por ejemplo etilenglicol, dietilenglicol, propilenglicol, butilenglicol, hexilenglicol, así como polietilenglicoles con un peso molecular medio de 100 a 1.000 dalton; mezclas técnicas de oligoglicérinas con un grado de condensación propia de 1 ,5 a 10, por ejemplo mezclas técnicas de diglicerinas con un contenido en diglicerina de un 40 a un 50% en peso; compuestos de metilol, en especial trimetilolmetano, trimetilolpropano, trimetilolbutano, pentaeritrita y dipentaeritrita; alquilglucósidos con una cadena de 1 a 8
átomos de carbono en el resto alquilo; alcoholes sacáricos con 5 a 12 átomos de carbono, por ejemplo sorbitol o manitol; azúcares con 5 a 12 átomos de carbono, por ejemplo glucosa o sacarosa; aminoazúcares, por ejemplo glucamina; dialcoholaminas como dietanolamina o 2-amino-1 ,3- propanodiol. To improve the fluidity of the compositions of the invention, hydrotropes, for example ethanol, isopropyl alcohol or polyols, can also be used. The polyols that come into consideration in this case preferably have from 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols may also contain other functional groups, especially amino groups, or be modified with nitrogen. Typical examples are glycerin; alkylene glycols, for example ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol, as well as polyethylene glycols with an average molecular weight of 100 to 1,000 dalton; technical mixtures of oligoglycerins with a degree of condensation of their own from 1.5 to 10, for example technical mixtures of diglycerins with a diglycerin content of 40 to 50% by weight; methylol compounds, especially trimethylolmethane, trimethylolpropane, trimethylolbutane, pentaerythrite and dipentaerythrite; alkyl glucosides with a chain from 1 to 8 carbon atoms in the alkyl moiety; saccharic alcohols with 5 to 12 carbon atoms, for example sorbitol or mannitol; sugars with 5 to 12 carbon atoms, for example glucose or sucrose; amino sugars, for example glucamine; dialcoholamines such as diethanolamine or 2-amino-1, 3- propanediol.
Preferentemente, en las composiciones de Ia invención como hidrótropo se emplea glicerina, propilenglicol y mezclas de los mismos. Preferably, glycerin, propylene glycol and mixtures thereof are used in the compositions of the invention as a hydrotrope.
Agentes conservantes Preservative agents
Entre los agentes conservantes apropiados para ser empleados en las composiciones de Ia invención se encuentran, a modo de ejemplo, fenoxietanol, disolución de formaldehído, parabenos (metilparabén, propilparabén, butilparabén y sus mezclas), 3-(4-clorofenox¡)-1 ,2- propanodiol (clorfenesina), pentanodiol o ácido sórbico, y las clases de sustancias adicionales indicadas en el Anexo Vl de Ia Directiva de Cosméticos 76/768/EEC. Among the preservative agents suitable for use in the compositions of the invention are, for example, phenoxyethanol, formaldehyde solution, parabens (methylparaben, propylparaben, butylparaben and mixtures thereof), 3- (4-chlorophenox) -1 , 2- propanediol (chlorphenesin), pentanediol or sorbic acid, and the classes of additional substances indicated in Annex Vl of the Cosmetics Directive 76/768 / EEC.
Preferentemente, como conservantes se emplean parabenos, clorfenesina, fenoxietanol o sus mezclas, en especial fenoxietanol, por ejemplo el producto COBIOSTAT® 200 de Ia compañía Cobiosa. Preferably, paraben, chlorphenesin, phenoxyethanol or mixtures thereof, especially phenoxyethanol, are used as preservatives, for example, the COBIOSTAT ® 200 product of the Cobiosa company.
Procedimiento de preparación Las composiciones cosméticas de Ia invención se pueden preparar siguiendo procedimientos convencionales en Ia industria cosmética para Ia preparación de lociones, leches, cremas, y emulsiones pulverizables. La preparación de emulsiones se describe por ejemplo en el manual Remington: The Science and Practice of Pharmacy, 20th edition, Lippincott Williams & Wilkins, Philadelphia, 2000 [ISBN: 0-683-306472]. Preparation procedure The cosmetic compositions of the invention can be prepared following conventional procedures in the cosmetic industry for the preparation of lotions, milks, creams, and sprayable emulsions. The preparation of emulsions is described for example in the Remington manual: The Science and Practice of Pharmacy, 20th edition, Lippincott Williams & Wilkins, Philadelphia, 2000 [ISBN: 0-683-306472].
Un procedimiento para preparar una composición de Ia invención puede ser, por ejemplo, el siguiente.
En un reactor equipado con un equipo de agitación, se pesan y funden, a una temperatura comprendida entre 650C y 850C, los componentes lipófilos y los emulsionantes. En otro recipiente se pesan y calientan, a una temperatura comprendida entre 650C y 850C, los componentes hidrófilos como agua, glicerina, pantenol y los agentes conservantes. A continuación, se procede a preparar una emulsión a partir de Ia masa lipófila y los componentes hidrófilos con agitación apropiada. Finalmente, se enfría Ia emulsión obtenida hasta una temperatura comprendida entre 3O0C y 450C y se añade, bajo agitación, Ia solución de resina de Crotón lechleri y otros componentes cosméticos que puedan ser sensibles a Ia temperatura. A process for preparing a composition of the invention can be, for example, the following. In a reactor equipped with a stirring equipment, weighed and melted at a temperature between 65 0 C and 85 0 C, the lipophilic components and emulsifiers. In another container are weighed and heated to a temperature between 65 0 C and 85 0 C, hydrophilic components such as water, glycerine, panthenol and preservatives. Then, an emulsion is prepared from the lipophilic mass and the hydrophilic components with appropriate agitation. Finally, the emulsion obtained to a temperature between 3O 0 C and 45 0 C cooled and added under stirring, the solution Croton lechleri resin and other cosmetic components may be sensitive to the temperature.
La composición cosmética obtenida presenta generalmente una viscosidad comprendida entre 100 y 100.000 cps. El pH de Ia composición se puede ajustar eventualmente con ácido cítrico, ácido clorhídrico o hidróxido sódico. Las composiciones de baja viscosidad (lociones, emulsiones PIT, microemulsiones) se pueden aplicar también por pulverización. Resulta especialmente preferente una composición cosmética que comprende Ia combinación de Ia invención, Ia cual comprende resina de Crotón lechleri y pantenol, y, como ingredientes cosméticos activos adicionales, aceite de Rosa mosqueta, manteca de karité y gel de aloe vera. También resulta especialmente preferente una composición cosmética que comprende Ia combinación de Ia invención, Ia cual comprende resina de Crotón lechleri y pantenol, y, como ingredientes cosméticos activos adicionales, extracto de Centella asiática, aceite de almendras dulces, aceite de Rosa mosqueta, manteca de karité, acetato de α-tocoferol, ácido glicirrético y gel de aloe vera. The cosmetic composition obtained generally has a viscosity between 100 and 100,000 cps. The pH of the composition can be adjusted with citric acid, hydrochloric acid or sodium hydroxide. Low viscosity compositions (lotions, PIT emulsions, microemulsions) can also be applied by spraying. Especially preferred is a cosmetic composition comprising the combination of the invention, which comprises Croton lechleri resin and panthenol, and, as additional active cosmetic ingredients, rosehip oil, shea butter and aloe vera gel. Also especially preferred is a cosmetic composition comprising the combination of the invention, which comprises Croton lechleri resin and panthenol, and, as additional active cosmetic ingredients, Centella asiatica extract, sweet almond oil, Rosehip oil, butter Shea, α-tocopherol acetate, glycyrrhetic acid and aloe vera gel.
Utilización Utilization
Forma parte también del objeto de Ia invención Ia utilización de Ia combinación de Ia invención para preparar una composición cosmética
para reducir los efectos de las agresiones a Ia piel. En una realización preferente, Ia combinación de Ia invención se emplea para reducir los efectos de Ia radiación láser en Ia piel. También es objeto de Ia invención Ia utilización de Ia composición cosmética de Ia invención para reducir los efectos de las agresiones a Ia piel. The use of the combination of the invention to prepare a cosmetic composition is also part of the object of the invention. to reduce the effects of aggressions to the skin. In a preferred embodiment, the combination of the invention is used to reduce the effects of laser radiation on the skin. The use of the cosmetic composition of the invention to reduce the effects of aggressions to the skin is also object of the invention.
En el contexto de Ia presente invención, por "agresiones a Ia piel" se entienden los daños producidos por las condiciones ambientales, por ejemplo por Ia exposición a Ia radiación ultravioleta de los rayos solares, el viento, Ia humedad, Ia contaminación ambiental o el frío; el envejecimiento, por ejemplo Ia deshidratación y Ia oxidación; y Ia radiación láser, por ejemplo Ia aplicación dermatológica de radiación láser para eliminar el vello. In the context of the present invention, "aggressions against the skin" means damage caused by environmental conditions, for example by exposure to ultraviolet radiation from sunlight, wind, moisture, environmental pollution or cold; aging, for example, dehydration and oxidation; and the laser radiation, for example the dermatological application of laser radiation to remove hair.
En una realización preferente, Ia composición de Ia invención se emplea para reducir los efectos de Ia radiación láser en Ia piel. Se efectuó un ensayo ¡n vivo en las piernas de individuos que se sometieron a una fotodepilación médica mediante láser. Tras dicho proceso de depilación, en una de las piernas se aplicó una crema hidratante corporal con aloe vera y en Ia otra pierna se aplicó Ia composición cosmética de Ia invención, comprendiendo Ia resina de Crotón lechleή y pantenol y, como ingredientes cosméticos activos adicionales, aceite de Rosa mosqueta, manteca de karité y gel de aloe vera. Al analizar los resultados se encontró en el 80% de los casos una disminución mayor y más rápida del eritema en Ia pierna en Ia que se aplicó Ia composición de Ia invención, frente a Ia que se aplicó Ia crema hidratante corporal con aloe vera. También se encontró que en el 90% de los casos Ia disminución del prurito y el escozor producidos por Ia fotodepilación se inició antes y fue más rápida en Ia pierna en Ia que se aplicó Ia composición de Ia invención, frente a Ia que se aplicó Ia crema hidratante corporal con aloe vera, si bien Ia desaparición total de estos
síntomas fue similar en ambas piernas. Por tanto, Ia composición cosmética de Ia invención constituye una respuesta eficaz y segura a Ia agresión física producida por el láser en Ia piel, ya que entre los efectos que produce se pueden destacar los siguientes: - reduce Ia inflamación y las irritaciones, In a preferred embodiment, the composition of the invention is used to reduce the effects of laser radiation on the skin. A live test was performed on the legs of individuals who underwent a medical laser photodepilation. After said hair removal process, on one of the legs a body moisturizer with aloe vera was applied and on the other leg the cosmetic composition of the invention was applied, comprising Crotón lechleή and panthenol resin and, as additional active cosmetic ingredients, Rosehip oil, shea butter and aloe vera gel. When analyzing the results, 80% of the cases found a greater and faster decrease in erythema in the leg in which the composition of the invention was applied, compared to which the body moisturizer with aloe vera was applied. It was also found that in 90% of the cases the decrease in pruritus and stinging caused by photoepilation began earlier and was faster in the leg in which the composition of the invention was applied, compared to which the Ia was applied. body moisturizer with aloe vera, although the total disappearance of these Symptoms were similar in both legs. Therefore, the cosmetic composition of the invention constitutes an effective and safe response to the physical aggression produced by the laser on the skin, since among the effects it produces, the following can be highlighted: - it reduces inflammation and irritations,
- disminuye Ia aparición de sobreinfecciones y de hiperpigmentaciones post-inflamatorias, - decreases the appearance of superinfections and post-inflammatory hyperpigmentation,
- acelera el proceso de reepitelización y normalización de Ia piel, y - accelerates the process of reepithelialization and normalization of the skin, and
- proporciona un efecto calmante y duradero. Es también objeto de Ia invención un procedimiento para reducir los efectos de las agresiones a Ia piel, que comprende aplicar sobre Ia piel una cantidad cosméticamente efectiva de una composición de Ia invención. La aplicación sobre Ia piel es una aplicación tópica, de manera que Ia composición se libera localmente en Ia zona de Ia piel afectada por Ia agresión. Una cantidad cosméticamente efectiva es aquella cantidad de composición de Ia invención que permite tratar toda Ia zona afectada. - provides a soothing and lasting effect. The object of the invention is also a method for reducing the effects of aggressions on the skin, which comprises applying a cosmetically effective amount of a composition of the invention to the skin. The application on the skin is a topical application, so that the composition is released locally in the area of the skin affected by the aggression. A cosmetically effective amount is that amount of composition of the invention that allows treating the entire affected area.
Ensayos de actividad antioxidante Antioxidant Activity Tests
La combinación de Ia invención se sometió a un ensayo ¡n vitro para determinar Ia actividad antioxidante de Ia misma. Para medir Ia capacidad antioxidante que tiene un compuesto se pueden utilizar métodos físico-químicos que valoran Ia capacidad de un compuesto para secuestrar radicales libres, también conocida como actividad captadora de radicales libres. En estos ensayos, Ia actividad valorada es independiente de cualquier actividad enzimática, tal como se describe en el artículo de Fauconneau et al., Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinífera cell cultures using in vitro tests, Life ScL, 1997, 61 , 2103-21 10. Dentro de este
grupo de métodos, uno de los ensayos más frecuentes es el que utiliza 2,2-difenil-1 -picrilhidrazilo (DPPH), tal como se describe en el artículo de Brand-Williams et al., Use of a Free Radical Method to Evalúate Antioxidant Activity, Lebensm. Wiss. Tecnol., 1995, 28, 25-30. El radical DPPH- es un radical estable a temperatura ambiente, que es reducido en presencia de compuestos antioxidantes. El uso de este radical constituye un método fácil y rápido para evaluar sustancias antioxidantes. The combination of the invention was subjected to an in vitro test to determine the antioxidant activity thereof. To measure the antioxidant capacity of a compound, physical-chemical methods can be used that assess the ability of a compound to sequester free radicals, also known as free radical scavenging activity. In these tests, the assessed activity is independent of any enzymatic activity, as described in the article by Fauconneau et al., Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinífera cell cultures using in vitro tests, Life ScL , 1997, 61, 2103-21 10. Within this group of methods, one of the most frequent tests is the one that uses 2,2-diphenyl-1-pyrillicrazil (DPPH), as described in the article by Brand-Williams et al., Use of a Free Radical Method to Evaluate Antioxidant Activity, Lebensm. Wiss Tecnol., 1995, 28, 25-30. The DPPH- radical is a stable radical at room temperature, which is reduced in the presence of antioxidant compounds. The use of this radical is an easy and fast method to evaluate antioxidant substances.
Empleando este método se comparó Ia actividad antioxidante de Ia combinación de Ia invención con Ia actividad de cada componente por separado. La combinación que se ensayó contenía una proporción pantenol:resina de Crotón lechlerí de 40:1 expresada en peso:peso. Using this method, the antioxidant activity of the combination of the invention was compared with the activity of each component separately. The combination tested contained a panthenol: Croton lechlerí resin ratio of 40: 1 expressed in weight: weight.
En Ia Tabla 1 se presentan las concentraciones EC50, que se refieren a Ia concentración eficaz del compuesto necesaria para captar el 50% de Ia cantidad total de radicales del DPPH, de modo que cuanto menor es Ia concentración, mayor es Ia eficacia del producto: Table 1 shows the EC 50 concentrations, which refer to the effective concentration of the compound necessary to capture 50% of the total amount of DPPH radicals, so that the lower the concentration, the greater the efficiency of the product :
Tabla 1 Table 1
A partir de todos los datos experimentales se comprobó con el programa de estadística Statgraphics® que las diferencias entre los tres grupos eran significativas al 99%.
Sorprendentemente se ha observado que Ia combinación de pantenol y resina de Crotón lechleri de Ia invención presenta una actividad antiradicalaria sinérgica, ya que Ia concentración EC50 de Ia combinación es inferior a Ia concentración para cada uno de los componentes por separado, y considerablemente inferior al valor que Ie correspondería teniendo en cuenta que Ia combinación incluye un 97,6% de pantenol y un 2,4% de resina de Crotón lechleri. From all the experimental data it was verified with the Statgraphics ® statistical program that the differences between the three groups were significant at 99%. Surprisingly, it has been observed that the combination of panthenol and Croton lechleri resin of the invention exhibits a synergistic anti-radical activity, since the EC 50 concentration of the combination is lower than the concentration for each of the components separately, and considerably less than corresponding value, taking into account that the combination includes 97.6% of panthenol and 2.4% of Croton lechleri resin.
Los ejemplos que siguen a continuación sirven para ilustrar Ia invención, pero no Ia limitan en modo alguno. The following examples serve to illustrate the invention, but do not limit it in any way.
Ejemplos Examples
Ejemplo 1 Preparación de una emulsión corporal en forma de crema que contiene Ia combinación de resina de Crotón lechleri y pantenol de Ia invención Example 1 Preparation of a body emulsion in the form of a cream containing the combination of Croton lechleri resin and panthenol of the invention
En un reactor de acero inoxidable equipado con un agitador se prepararon los componentes de Ia fase lipófila. Para ello se introdujeron en el mismo 4 kg de Montanov® 68 (mezcla de alcohol cetearílico y glucósido de cetearilo), 4 kg de Cetiol® CC (carbonato de dicaprililo), 3 kg de Mirytol® 318 (triglicérido caprílico-cáprico), 0,5 kg de aceite de Rosa mosqueta, 3 kg de Cetiol® 868 (estearato de 2-etilhexilo), 2 kg de manteca de karité y 0,5 kg de Simulgel® EG (mezcla de isohexadecano, monooleato de sorbitán etoxilado con 20 moles de óxido de etileno y copolímero de acrilato de hidroxietilo y acriloildimetiltaurato sódico), y se calentó Ia masa a 80 ± 20C bajo agitación. In a stainless steel reactor equipped with an agitator, the components of the lipophilic phase were prepared. For this purpose, 4 kg of Montanov ® 68 (mixture of cetearyl alcohol and cetearyl glucoside), 4 kg of Cetiol ® CC (dicaprilyl carbonate), 3 kg of Mirytol ® 318 (caprylic-capric triglyceride), 0 , 5 kg of Rosehip oil, 3 kg of Cetiol ® 868 (2-ethylhexyl stearate), 2 kg of shea butter and 0.5 kg of Simulgel ® EG (mixture of isohexadecane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide and copolymer of hydroxyethyl acrylate and sodium acryloyl dimethyl restaurant, and the mass was heated to 80 ± 2 0 C with stirring.
En otro reactor de acero inoxidable equipado con un agitador se prepararon los componentes de Ia fase hidrófila. Para ello se introdujeron en el mismo 50 kg de agua desmineralizada, 3 kg de glicerina del 99,5%,
2 kg de pantenol, y 2,5 kg de de Cobiostab® 200 (fenoxietanol), y se calentó Ia masa a 80 ± 20C bajo agitación. A esta temperatura se incorporó Ia fase hidrófila sobre Ia fase lipófila bajo agitación hasta conseguir una emulsión. A continuación, se inició un proceso de enfriamiento a 35 ± 20C. Una vez alcanzada esta temperatura, se añadieron 3 kg de una solución hidroglicólica de resina de Crotón lechleri con un contenido en resina del 1 ,68% en peso, 3 kg de gel de aloe vera (10:1 ), y Ia masa se mantuvo bajo agitación hasta conseguir un producto homogéneo. Finalmente se completó con agua para obtener 100 kg de emulsión corporal en forma de crema. Se ajustó el pH a un valor comprendido entre 5 y 6. El producto final tenía una viscosidad comprendida entre 12.000 y 20.000 cps. The components of the hydrophilic phase were prepared in another stainless steel reactor equipped with a stirrer. For this, 50 kg of demineralized water, 3 kg of 99.5% glycerin were introduced into it, 2 kg of panthenol, and 2.5 kg of Cobiostab® 200 (phenoxyethanol), and the mass was heated to 80 ± 2 0 C with stirring. At this temperature, the hydrophilic phase was incorporated on the lipophilic phase under stirring until an emulsion was achieved. Then, a cooling process was started at 35 ± 2 0 C. Once this temperature was reached, 3 kg of a Crotón lechleri resin hydroglycolic solution with a resin content of 1.68% by weight, 3 kg was added Aloe Vera gel (10: 1), and the dough was kept under stirring until a homogeneous product was obtained. Finally it was completed with water to obtain 100 kg of body emulsion in the form of cream. The pH was adjusted to a value between 5 and 6. The final product had a viscosity between 12,000 and 20,000 cps.
Ejemplo 2. Preparación de una emulsión corporal en forma de crema con Ia combinación de resina de Crotón lechleri y pantenol de Ia invención y extracto deExample 2. Preparation of a body emulsion in the form of cream with the combination of Croton lechleri resin and panthenol of the invention and extract of
Centella asiática Asiatic spark
En un reactor de acero inoxidable equipado con un agitador se prepararon los componentes de Ia fase hidrófila. Para ello se introdujeron en el mismo 50 kg de agua desmineralizada, 2 kg de glicerina del 99,5%, 3 kg de extracto hidroalcohólico de Centella asiática, 2 kg de3 pantenol yThe components of the hydrophilic phase were prepared in a stainless steel reactor equipped with a stirrer. For this, 50 kg of demineralized water, 2 kg of 99.5% glycerin, 3 kg of hydroalcoholic extract of Centella asiatica, 2 kg of 3 panthenol were introduced therein.
2,5 kg de de Cobiostab® 200 (fenoxietanol), y se calentó Ia masa a 75 ± 20C bajo agitación. Sobre Ia fase hidrófila se añadió 1 kg de Simulgel® NS (mezcla de escualano, monooleato de sorbitán etoxilado con 20 moles de óxido de etileno y copolímero de acrilato de hidroxietilo y acroloildimetiltaurato sódico), se agitó a alta velocidad hasta conseguir un gel homogéneo y se mantuvo a 75 ± 20C bajo agitación. 2.5 kg of Cobiostab ® 200 (phenoxyethanol), and the mass was heated to 75 ± 2 0 C with stirring. On the hydrophilic phase, 1 kg of Simulgel ® NS (mixture of squalane, ethoxylated sorbitan monooleate with 20 moles of ethylene oxide and hydroxyethyl acrylate copolymer and sodium acrylo dimethyl restaurant) was added, stirred at high speed until obtaining a homogeneous gel and kept at 75 ± 2 0 C under stirring.
En otro reactor de acero inoxidable equipado con un agitador se prepararon los componentes de Ia fase lipófila. Para ello se introdujeron en el mismo 4 kg de Montanov® 68 (mezcla de alcohol cetearílico y
glucósido de cetearilo), 2 kg de Montanov® 14 (mezcla de alcohol mirístico y glucósido de miristilo), 6 kg de aceite de almendras dulces. 0,5 kg de aceite de Rosa Mosqueta, 4 kg de Eutanol® G (octildodecanol), 8 kg de Cetiol® 868 (estearato de 2-etilhexilo), 2 kg de manteca de Karité, 0,2 kg de acetato de tocoferol, y se calentó Ia masa a 75 ± 20C bajo agitación. A continuación, se incorporó Ia fase lipófila al reactor que contenía los otros componentes y se agitó hasta conseguir una emulsión. Bajo agitación se añadieron seguidamente 0,5 kg de Plantactiv® GLA 18 (ácido glicirrético), y se inició el enfriamiento hasta 40 ± 20C. Una vez alcanzada dicha temperatura, se añadieron 3 kg de solución hidroglicólica de resina deIn another stainless steel reactor equipped with a stirrer, the components of the lipophilic phase were prepared. For this, 4 kg of Montanov ® 68 (mixture of cetearyl alcohol and cetearyl glycoside), 2 kg of Montanov ® 14 (mixture of myristic alcohol and myristyl glycoside), 6 kg of sweet almond oil. 0.5 kg of Rosehip oil, 4 kg of Eutanol ® G (octyldodecanol), 8 kg of Cetiol ® 868 (2-ethylhexyl stearate), 2 kg of Shea butter, 0.2 kg of tocopherol acetate, and the mass was heated to 75 ± 2 0 C under stirring. Then, the lipophilic phase was incorporated into the reactor containing the other components and stirred until an emulsion was achieved. Under stirring, 0.5 kg of Plantactiv ® GLA 18 (glycyrrhetic acid) was then added, and cooling to 40 ± 2 0 C was started. Once this temperature was reached, 3 kg of hydrochloric solution of resin were added.
Crotón lechlerí con un contenido en resina del 1 ,68% en peso, 3 kg de gel de aloe vera (10:1 ), y se agitó Ia masa hasta homogeneización. Finalmente se completó con agua para obtener 100 kg de emulsión corporal en forma de crema. Se ajustó el pH a un valor comprendido entre 5 y 6. El producto final tenía una viscosidad comprendida entre 20.000 yCrotón lechlerí with a resin content of 1.68% by weight, 3 kg of aloe vera gel (10: 1), and the mass was stirred until homogenization. Finally it was completed with water to obtain 100 kg of body emulsion in the form of cream. The pH was adjusted to a value between 5 and 6. The final product had a viscosity between 20,000 and
70.000 cps. 70,000 cps
Ejemplo 3. Ensayo de Ia actividad antioxidante Example 3. Test of the antioxidant activity
La actividad antioxidante se determinó mediante el ensayo in vitro descrito en el artículo de Brand-Williams et al., Use of a Free Radical Method to Evalúate Antioxidant Activity, Lebensm. Wiss. Tecnol., 1995,The antioxidant activity was determined by the in vitro assay described in the article by Brand-Williams et al., Use of a Free Radical Method to Evaluate Antioxidant Activity, Lebensm. Wiss Tecnol., 1995,
28, 25-30. En este método, el extracto o Ia sustancia a valorar reacciona con 1 ,1-difenil-2-picrilhidrazilo (DPPH) en una disolución etanólica. El DPPH es un radical libre orgánico relativamente estable que, en un átomo del puente de nitrógeno, muestra un electrón de valencia no apareado. Es reducido en presencia de compuestos antioxidantes, y esta reducción se monitoriza por Ia disminución de Ia absorbancia de este radical. 28, 25-30. In this method, the extract or the substance to be evaluated reacts with 1,1-diphenyl-2-picrylhydrazyl (DPPH) in an ethanolic solution. DPPH is a relatively stable organic free radical that, in an atom of the nitrogen bridge, shows an unpaired valence electron. It is reduced in the presence of antioxidant compounds, and this reduction is monitored by the decrease in the absorbance of this radical.
En este ensayo se determina Ia concentración inicial de DPPH y Ia concentración resultante una vez que se ha añadido el posible antioxidante, de forma que una disminución de Ia absorción de radiación
se traduce en una disminución de Ia concentración de DPPH debida a Ia cesión de electrones. Los resultados del ensayo se expresan como concentración EC50, que es Ia concentración del ingrediente activo necesaria para decolorar en un 50% el DPPH, esto es, para captar el 50% de Ia cantidad total de radicales DPPH. De esta forma, cuanto más pequeño es el valor de Ia concentración EC50, menor es Ia concentración eficaz necesaria para captar el 50% del DPPH, y, por tanto, mayor Ia capacidad de eliminar radicales del componente ensayado. Cuando Ia concentración EC50 es alta significa que Ia concentración eficaz que se necesita de ese compuesto para que actúe como antioxidante es mayor. In this test, the initial concentration of DPPH and the resulting concentration are determined once the possible antioxidant has been added, so that a decrease in radiation absorption It translates into a decrease in the concentration of DPPH due to the transfer of electrons. The results of the test are expressed as the EC 50 concentration, which is the concentration of the active ingredient necessary to bleach the DPPH by 50%, that is, to capture 50% of the total amount of DPPH radicals. In this way, the smaller the value of the EC 50 concentration, the lower the effective concentration necessary to capture 50% of the DPPH, and, therefore, the greater the ability to eliminate radicals from the tested component. When the EC 50 concentration is high, it means that the effective concentration needed for that compound to act as an antioxidant is higher.
Las muestras que se ensayaron fueron las siguientes: a) Combinación de Ia invención formada por resina de Crotón lechleri disuelta en una solución hidroglicólica y pantenol en una proporción 1 :40 en peso b) Pantenol c) Resina de Crotón lechleri disuelta en una solución hidroglicólica The samples that were tested were the following: a) Combination of the invention formed by Croton lechleri resin dissolved in a hydro-glycol solution and panthenol in a 1: 40 weight ratio b) Panthenol c) Croton lechleri resin dissolved in a hydro-glycol solution
Como control positivo se empleó vitamina E ((±)-α-tocoferol, 1 ,1 unidades/mg) y vitamina C (L-ácido ascórbico, > 99,0%) Vitamin E ((±) -α-tocopherol, 1.1 units / mg) and vitamin C (L-ascorbic acid,> 99.0%) were used as a positive control.
Se preparó una disolución de DPPH (Sigma Chemical) 0,1 mM en etanol. A partir de esta disolución se prepararon cinco disoluciones a las concentraciones 0,02 mM, 0,04 mM, 0,06 mM, 0,08 mM y 0,1 mM. Se midió Ia absorbancia de estas disoluciones a una longitud de onda de 515 nm para obtener Ia recta de calibrado. La solución de DPPH en etanol se tomó como blanco de estas muestras. A continuación, se prepararon disoluciones concentradas de las muestras a examinar, con una concentración aproximada de 10 g/l. Se tomaron 0,05 mi de de dichas disoluciones concentradas y se les
añadieron 2 mi de Ia disolución de DPPH 0,1 mM. En caso de que Ia disminución de Ia absorción sea muy rápida, se puede realizar una disolución apropiada del extracto. La disolución etanólica de DPPH se empleó como blanco de estas muestras. Tras una incubación de 30 minutos a 370C, se monitorizó Ia reducción del radical DPPH en un espectrofotómetro a partir de Ia disminución de Ia absorbancia de dicho radical a 515 nm. El porcentaje de decoloración del DPPH fue calculado de acuerdo a Ia siguiente expresión: fAm— Abm\ A solution of 0.1 mM DPPH (Sigma Chemical) in ethanol was prepared. From this solution five solutions were prepared at the concentrations 0.02 mM, 0.04 mM, 0.06 mM, 0.08 mM and 0.1 mM. The absorbance of these solutions was measured at a wavelength of 515 nm to obtain the calibration line. The DPPH solution in ethanol was taken as the blank of these samples. Then, concentrated solutions of the samples to be examined were prepared, with an approximate concentration of 10 g / l. 0.05 ml of said concentrated solutions were taken and given They added 2 ml of the 0.1 mM DPPH solution. In case the decrease in absorption is very rapid, an appropriate dissolution of the extract can be performed. The DPPH ethanolic solution was used as the target of these samples. After incubation for 30 minutes at 37 0 C, the reduction of DPPH radical was monitored in a spectrophotometer from the absorbance of the decrease of said radical at 515 nm. The percentage of DPPH discoloration was calculated according to the following expression: fAm— Abm \
% Decoloración = 1 - X 1000 % Discoloration = 1 - X 1000
V Ab DPp H J V Ab DP p H J
donde: where:
Am = Absorbancia de Ia muestra. Am = Absorbance of the sample.
Abm = Absorbancia del blanco de Ia muestra. Abm = Absorbance of the blank of the sample.
AÓDPPH - Asorbancia del blanco de Ia solución etanólica de DPPH. Para calcular EC50 o Ia concentración del extracto necesaria para decolorar en un 50% el DPPH, se tomaron cuatro mediciones de cada una de las concentraciones del extracto y se aseguró que Ia variabilidad entre ellas no superara el 10%. En Ia Tabla 2 se presentan las concentraciones EC50, expresadas en μg/ml, determinadas para Ia combinación de Ia invención y para los ingredientes cosméticos por separado.
AÓ DPPH - Asorbance of the target of the ethanolic solution of DPPH. To calculate EC 50 or the concentration of the extract necessary to bleach the DPPH by 50%, four measurements of each of the concentrations of the extract were taken and it was ensured that the variability between them did not exceed 10%. Table 2 shows the EC 50 concentrations, expressed in μg / ml, determined for the combination of the invention and for the cosmetic ingredients separately.
Tabla 2 Table 2
Se puede observar que Ia combinación de Ia invención presenta una importante actividad captadora de radicales libres a una concentración EC50 de 4,87 μg/ml, comparable a Ia de Ia Vitamina C. Dicha concentración es inferior a Ia concentración EC5O de Ia resina de Crotón lechleri sola (6,85 μg/ml) y a Ia del pantenol solo (18,25 μg/ml). Las diferencias entre estos tres componentes son estadísticamente significativas al 99%. It can be seen that the combination of the invention has an important free radical scavenging activity at an EC 50 concentration of 4.87 μg / ml, comparable to that of Vitamin C. Said concentration is lower than the EC 5O concentration of the resin. Croton lechleri alone (6.85 μg / ml) and Ia of panthenol alone (18.25 μg / ml). The differences between these three components are statistically significant at 99%.
Teniendo en cuenta que Ia combinación de Ia invención ensayada contiene una proporción pantenol:resina de 40:1 , que supone un 97,6% en peso de pantenol y unt 2,4% en peso de resina de Crotón lechleri, el valor esperable de Ia concentración EC5O para dicha combinación era de 17,97 μg/ml (18,25 x 0,976 + 6,85 x 0,024).
Se observa pues un efecto sinérgico en cuanto a Ia actividad antioxidante al combinar Ia resina de Crotón lechleri con pantenol.
Taking into account that the combination of the tested invention contains a panthenol: resin ratio of 40: 1, which represents 97.6% by weight of panthenol and 2.4% by weight of Croton lechleri resin, the expected value of The EC 5O concentration for said combination was 17.97 μg / ml (18.25 x 0.996 + 6.85 x 0.024). A synergistic effect regarding the antioxidant activity is thus observed when combining Crotón lechleri resin with panthenol.
Claims
1. Combinación de ingredientes activos cosméticos, caracterizada porque comprende: a) resina de Crotón lechleh y b) pantenol. 1. Combination of cosmetic active ingredients, characterized in that it comprises: a) Croton lechleh resin and b) panthenol.
2. Combinación según Ia reivindicación 1 , caracterizada porque La proporción entre Ia resina de Crotón lechlerí y el pantenol está comprendida entre 1 :500 y 1 :2, expresada en peso:peso. 2. Combination according to claim 1, characterized in that the ratio between Crotón lechlerí resin and panthenol is between 1: 500 and 1: 2, expressed in weight: weight.
3. Combinación según cualquiera de las reivindicaciones 1 ó 2, caracterizada porque el pantenol se selecciona entre D-pantenol y una mezcla racémica de D-pantenol y L-pantenol. 3. A combination according to any one of claims 1 or 2, characterized in that the panthenol is selected from D-panthenol and a racemic mixture of D-panthenol and L-panthenol.
4. Combinación según Ia reivindicación 3, caracterizada porque el pantenol es D-pantenol. 4. Combination according to claim 3, characterized in that the panthenol is D-panthenol.
5. Composición cosmética que comprende Ia combinación según cualquiera de las reivindicaciones 1 a 4 y un vehículo cosméticamente aceptable. 5. Cosmetic composition comprising the combination according to any of claims 1 to 4 and a cosmetically acceptable vehicle.
6. Composición según Ia reivindicación 5, caracterizada porque contiene: entre un 1% y un 20% en peso de Ia combinación según cualquiera de las reivindicaciones 1 a 4, y entre un 80% y un 99% en peso de un vehículo cosméticamente aceptable, ajustándose los porcentajes de los componentes de modo que el balance sea del 100%. 6. Composition according to claim 5, characterized in that it contains: between 1% and 20% by weight of the combination according to any of claims 1 to 4, and between 80% and 99% by weight of a cosmetically acceptable vehicle , adjusting the percentages of the components so that the balance is 100%.
7. Composición según cualquiera de las reivindicaciones 5 ó 6, caracterizada porque el vehículo es agua. 7. Composition according to any of claims 5 or 6, characterized in that the vehicle is water.
8. Composición según Ia reivindicación 5, caracterizada porque comprende al menos un ingrediente cosmético adicional. 8. Composition according to claim 5, characterized in that it comprises at least one additional cosmetic ingredient.
9. Composición según Ia reivindicación 8, caracterizada porque contiene: 9. Composition according to claim 8, characterized in that it contains:
- entre un 1 % y un 10% en peso de Ia combinación según cualquiera de las reivindicaciones 1 a 4, - between 1% and 10% by weight of the combination according to any of claims 1 to 4,
- entre un 5% y un 50% en peso de al menos un ingrediente cosmético adicional, y - between 5% and 50% by weight of at least one additional cosmetic ingredient, and
- entre un 40% y un 94% en peso de vehículo, ajustándose los porcentajes de los componentes de modo que el balance sea del 100%. - between 40% and 94% by weight of the vehicle, adjusting the percentages of the components so that the balance is 100%.
10. Composición según cualquiera de las reivindicaciones 8 a 9, caracterizada porque el ingrediente cosmético adicional se selecciona de entre el grupo formado por agentes tensioactivos y emulsionantes, compuestos lipidíeos y emolientes, factores de consistencia y agentes espesantes, hídrótropos, agentes conservantes y mezclas de los mismos. 10. Composition according to any one of claims 8 to 9, characterized in that the additional cosmetic ingredient is selected from the group consisting of surfactants and emulsifiers, lipid compounds and emollients, consistency factors and thickeners, hydrotropes, preservatives and mixtures of the same.
11. Composición según cualquiera de las reivindicaciones 5 a 10, caracterizada porque se encuentra en forma de emulsión del tipo aceite en agua (O/W). Composition according to any one of claims 5 to 10, characterized in that it is in the form of an emulsion of the oil-in-water type (O / W).
12. Composición según cualquiera de Ia reivindicaciones 8 a 1 1 , caracterizada porque incluye al menos un ingrediente activo cosmético seleccionado de entre el grupo formado por: extracto de12. Composition according to any of claims 8 to 1 1, characterized in that it includes at least one cosmetic active ingredient selected from the group consisting of: extract of
Centella asiática, gel de Aloe vera, aceite de Rosa mosqueta, aceite de almendras dulces, manteca de karité, ácido glicirrético, vitamina E y sus derivados y mezclas de los mismos. Centella asiatica, Aloe vera gel, Rosehip oil, Sweet almond oil, shea butter, glycyrrhetic acid, vitamin E and its derivatives and mixtures thereof.
13. Composición según Ia reivindicación 12, caracterizada porque como ingredientes cosméticos activos adicionales incluye aceite de Rosa mosqueta, manteca de karité y gel de aloe vera. 13. Composition according to claim 12, characterized in that as additional active cosmetic ingredients includes rosehip oil, shea butter and aloe vera gel.
14. Composición según Ia reivindicación 12, caracterizada porque como ingredientes cosméticos activos adicionales incluye extracto de Centella asiática, aceite de almendras dulces, aceite de Rosa mosqueta, manteca de karité, acetato de α-tocoferol, ácido glicirrético y gel de aloe vera. 14. Composition according to claim 12, characterized in that as additional active cosmetic ingredients includes Centella asiatica extract, sweet almond oil, rosehip oil, shea butter, α-tocopherol acetate, glycyrrhetic acid and aloe vera gel.
15. Utilización de Ia combinación según cualquiera de las reivindicaciones 1 a 4 para preparar una composición cosmética para reducir los efectos de las agresiones a Ia piel. 15. Use of the combination according to any of claims 1 to 4 to prepare a cosmetic composition to reduce the effects of aggressions on the skin.
16. Utilización según Ia reivindicación 15, caracterizada porque las agresiones a Ia piel son daños producidos por las condiciones ambientales, el envejecimiento y Ia radiación láser. 16. Use according to claim 15, characterized in that the aggressions to the skin are damages produced by environmental conditions, aging and laser radiation.
17. Utilización según Ia reivindicación 16, caracterizada porque las agresiones a Ia piel son producidas por Ia radiación láser. 17. Use according to claim 16, characterized in that the aggressions to the skin are produced by the laser radiation.
18. Utilización de Ia composición cosmética según cualquiera de las reivindicaciones 5 a 14 para reducir los efectos de las agresiones a18. Use of the cosmetic composition according to any of claims 5 to 14 to reduce the effects of the aggressions to
Ia piel. The skin.
19. Procedimiento para reducir los efectos de las agresiones a Ia piel, caracterizado porque comprende aplicar sobre Ia piel una cantidad cosméticamente efectiva de una composición según cualquiera de las reivindicaciones 5 a 14. 19. Procedure for reducing the effects of aggressions on the skin, characterized in that it comprises applying on the skin a cosmetically effective amount of a composition according to any of claims 5 to 14.
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ES200901695A ES2353541B1 (en) | 2009-07-30 | 2009-07-30 | COMBINATION OF COSMETIC ACTIVE INGREDIENTS AND COSMETIC COMPOSITION OBTAINED FROM THE SAME, AND ITS USE. |
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KR101915655B1 (en) * | 2011-10-26 | 2018-11-06 | (주)아모레퍼시픽 | Cosmetic composition containing Croton Lechleri resin extract |
US11389392B2 (en) | 2017-06-13 | 2022-07-19 | Mary Kay Inc. | Cosmetic compositions and methods for their use in firming skin |
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CN104983647A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Deep restoration mask and making method thereof |
WO2018015593A1 (en) * | 2016-07-07 | 2018-01-25 | Diater Laboratorio De Diagnóstico Y Aplicaciones Terapéuticas, S.A. | Compositions comprising cromoglicic acid for the treatment of dermatitis |
CN109715153A (en) * | 2016-07-07 | 2019-05-03 | 迪亚特实验室诊断和治疗应用公司 | For treating the composition comprising Cromoglycic acid of dermatitis |
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