CN115024994A - High-safety sunscreen composition and preparation method and application thereof - Google Patents
High-safety sunscreen composition and preparation method and application thereof Download PDFInfo
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- CN115024994A CN115024994A CN202210593580.4A CN202210593580A CN115024994A CN 115024994 A CN115024994 A CN 115024994A CN 202210593580 A CN202210593580 A CN 202210593580A CN 115024994 A CN115024994 A CN 115024994A
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- CN
- China
- Prior art keywords
- sunscreen
- sunscreen composition
- composition
- dimethicone
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 113
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 105
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000002537 cosmetic Substances 0.000 claims abstract description 36
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 17
- 239000011787 zinc oxide Substances 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 238000012216 screening Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 16
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 16
- 229940008099 dimethicone Drugs 0.000 claims description 14
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 13
- 239000003974 emollient agent Substances 0.000 claims description 13
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 10
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
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- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- 229960000601 octocrylene Drugs 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940048845 polyglyceryl-3 diisostearate Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
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- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
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- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and relates to a high-safety sunscreen composition as well as a preparation method and application thereof. The personal care sunscreen composition is formed by mixing one or a combination of a macromolecular organic ultraviolet absorber, an inorganic ultraviolet screening agent titanium dioxide and zinc oxide and other cosmetically acceptable ingredients, is safe and non-toxic, and can scatter ultraviolet rays and perform photothermal conversion on the absorbed ultraviolet rays; in addition, the macromolecular organic ultraviolet absorbent has better light stability, safety and high efficiency, so that the cosmetics are easy to spread and disperse, the sticky feeling is reduced, and the application field of the cosmetics is expanded.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a high-safety sunscreen composition as well as a preparation method and application thereof.
Background
Ultraviolet rays are the main focus of research in photo-aging at the present stage. The ultraviolet rays are divided into three bands of UVA, UVB and UVC. Wherein UVC is almost completely absorbed by the ozone layer and does not reach the earth's surface. UVA is ultraviolet light with wavelength of 280-320nm, most of which is absorbed by the epidermis of the skin, and can denature nucleic acid or protein in cells on the surface of the skin, so that the skin turns red, generates erythema (sunburn), and generates acute dermatitis which is often called sunburn. The magnitude of the SPF (Sun Protection factor) value is generally used to evaluate the resistance of sunscreen cosmetics to UVB. Excessive ultraviolet radiation also causes skin cancer. UVA is ultraviolet light with the wavelength of 320-400nm, has strong penetrating power, can reach the dermis layer of the skin, destroys collagen and elastin of the skin, and causes the generation of wrinkles, and the damage is cumulative and is a main cause of photoaging, and simultaneously stimulates the generation of melanin, so that the skin color is not uniform. The protection of sunscreen cosmetics against UVA is generally evaluated by the sun protection factor pa (protection UVA).
Sunscreen agents used in cosmetics in the market are mainly classified into organic ultraviolet absorbers and inorganic ultraviolet screening agents. The inorganic ultraviolet screening agent which is determined by the national safety of each country mainly comprises titanium dioxide and zinc oxide, and the limitation of each country to the type and the maximum addition amount of the organic ultraviolet absorbent is different. Inorganic ultraviolet screening agents are considered to be non-toxic and safe to humans. The sun-screening cosmetic is not irritant to skin and carcinogenic, but the sun-screening cosmetic is white and thick due to the addition of a large amount of titanium dioxide and zinc oxide, is not easy to coat and disperse, and is poor in consumer experience.
Although the skin is a barrier, it is not completely impermeable and molecules of sufficiently small molecular weight can penetrate the skin layers and then be absorbed, this amount being generally considered to be 500 daltons. Currently there are no effective topical drugs with molecular weights above 500 daltons, and almost all known allergens are below 500 daltons. Although sunscreen products using organic uv absorbers can provide fresh skin feel, related studies have confirmed that some organic uv absorbers with small molecular weight (e.g., avobenzone, octocrylene, benzophenone) can permeate the skin and enter the blood, and thus have a great safety hazard in human use. Safety is the most limiting factor in the use of sunscreens, with large molecule sunscreens greatly increasing safety compared to small molecule sunscreens, and organic small molecule sunscreens have been shown to have potential safety risks (endocrine disruption, induction of infant congenital giant colon, etc.). Based on this theory, only high molecular weight chemical sunscreens were selected to reduce skin irritation when developing sunscreen products.
The skin is damaged by ultraviolet radiation and then becomes dry and rough, and loses elasticity and luster. Therefore, sun protection is of great importance. Desert muscle is the symptom of roughness, red heat, desquamation, etc., and the skin is dry like desert skin, which is mainly caused by long-term injury accumulation, such as frequent exposure, careless maintenance, frequent cutin removal, etc. The desert muscle is weak in sebum membrane and extremely sensitive to skin, and particularly is easily stimulated by the outside to generate cell inflammation when exposed to the sun, so that normal physiological functions of the skin such as self-repair and renewal are affected, certain destructive factors can be generated, the skin is damaged, the dryness condition is further worsened, and the aging process of the skin is accelerated.
On the premise of ensuring the sun-screening effect, the modern sun-screening technology usually needs to add a large amount of small-molecular organic sun-screening agents, and risks of light instability, irritation and safety can exist, so that the development of macromolecular mild sun-screening cosmetics suitable for sensitive muscles and desert muscles is vital. However, since the organic sunscreen agent with large molecular weight is basically in a crystalline form, crystallization is easy to separate out in a formula system, and the problem of solubilization is also the problem to be solved by the invention.
Disclosure of Invention
In one aspect, the present application provides a sunscreen composition, comprising the following materials by weight:
0.1-10% of diethyl hexyl butamido triazone and 0.1-10% of bis-ethylhexyloxyphenol methoxyphenyl triazine.
In some embodiments, the sunscreen composition further comprises the following materials in weight percent: 150.1-10% of polysiloxane and 0.1-5% of ethylhexyl triazone.
In some embodiments, the sunscreen composition further comprises a physical sunscreen agent; in some embodiments, the physical sunscreen agent is selected from one or both of zinc oxide or titanium dioxide; in some embodiments, the weight percentage of the physical sunscreen in the sunscreen composition is: 0.05-20% of zinc oxide and 0.05-20% of titanium dioxide; in some embodiments, the physical sunscreen is a surface treated physical sunscreen; in some embodiments, the surface treatment is treatment with triethoxycaprylylsilane as a surface treatment agent.
In some embodiments, the sunscreen composition further comprises one or more of an emulsifier, a film former, an emollient, a thickener, a humectant, a chelating agent, a preservative, a skin conditioner, an aromatizer, a pH adjuster, a solvent.
In some embodiments, the emulsifier is selected from one or more of PEG-9 dimethiconoethyl dimethicone, polyglyceryl-3 dimethicone hydroxyethyl dimethicone, lauryl polyethylene glycol/polypropylene glycol-18/18-dimethicone, PEG-10 dimethicone, polyglyceryl-3 polyricinoleate, polyglyceryl-3 diisostearate; in some embodiments, the emulsifier is selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone and PEG-10 dimethicone.
In some embodiments, the film forming agent is selected from one or more of trimethylsiloxysilicate, polyurethane, hydrogenated polycyclopentadiene; in some embodiments, the film forming agent is selected from trimethylsiloxysilicate.
In some embodiments, the emollient is selected from one or more of glycerol tri (ethyl hexanoate), caprylic/capric triglyceride, pentaerythritol tetra (ethyl hexanoate), butyl octanol salicylate, diethoxyethyl succinate, isododecane, cetyl ethylhexanoate, isopropyl myristate, isopropyl palmitate, diisopropyl sebacate, dibutyl adipate, C12-15 alcohol benzoate, dioctyl carbonate, coco-caprylic/capric acid ester, polydimethylsiloxane, octyl methicone, cyclopentadecyldimethicone, phenyl trimethicone; in some embodiments, the emollient is selected from caprylic/capric triglyceride, isopropyl palmitate, C12-15 alcohol benzoate, cyclopentadimethylsiloxane; in some embodiments, the weight percentage of the emollient in the sunscreen composition is: 0.5-20% of caprylic/capric triglyceride, 0.5-20% of isopropyl palmitate and 0.5-20% of C12-15 alcohol benzoate.
In some embodiments, the thickener is selected from one or more of disteardimonium hectorite, silica silylate, dextrin palmitate; in some embodiments, the thickener is selected from disteardimonium hectorite.
In some embodiments, the pH adjusting agent is selected from one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethylpropanol.
The application also provides the application of the sunscreen composition in the preparation of cosmetics; in some embodiments, the cosmetic is selected from any one of a sunscreen lotion, a sunscreen cream, a sunscreen lotion, a sunscreen spray, a sunscreen gel, a sun screen cream, a sun screen lotion, and a BB cream.
The application also provides a preparation method of the sunscreen composition, which comprises the step of mixing the components.
The sunscreen cosmetic composition of the present invention is obtained by mixing an oil phase and a water phase, and adding other components.
The oil phase mainly comprises emulsifier, film-forming agent, emollient, sunscreen agent, and oil phase thickener, but may also contain other components as required.
The emulsifier is not particularly limited as long as it can form a water-in-oil (W/O) type or oil-in-water (O/W) type emulsified sunscreen cosmetic composition, and examples thereof include PEG-9 dimethiconoethyl dimethicone, polyglycerin-3 dimethiconohydroxyethyl dimethicone, lauryl polyethylene glycol/polypropylene glycol-18/18-dimethicone, PEG-10 dimethicone, polyglycerin-3 polyricinoleate, polyglycerin-3 diisostearate, and the like.
Examples of the film-forming agent include trimethylsiloxysilicate, polyurethane, and hydrogenated polycyclopentadiene.
The emollient may be any emollient commonly used in the cosmetic field, and is not particularly limited.
Specifically, triglyceride of glycerol tri (ethyl hexanoate), caprylic/capric triglyceride, pentaerythritol tetra (ethyl hexanoate), butyl octanol salicylate, diethoxyethyl succinate, isododecane, cetyl ethylhexanoate, isopropyl myristate, isopropyl palmitate, diisopropyl sebacate, dibutyl adipate, C12-15 alcohol benzoate, dioctyl carbonate, coco-caprylic/capric acid ester, polydimethylsiloxane, octyl methicone, cyclopentadecyldimethicone, phenyl trimethicone, and the like can be used.
As sunscreens, organic uv absorbers contain only high molecular weight, and molecular weights greater than 500 daltons, including oil soluble: polysiloxane-15, ethylhexyl triazone, diethyl hexyl butamido triazone, cresoltrazol trisiloxane, bis-ethylhexyloxyphenol methoxyphenyl triazine, water soluble: disodium phenyl dibenzoimidazole tetrasulfonate and organic microparticles: two or more of methylenebis-benzotriazolyl tetramethylbutylphenol. Inorganic ultraviolet blockers titanium dioxide and zinc oxide may be used.
The oil phase thickener may be disteardimonium hectorite, silica silylate, dextrin palmitate, or the like.
The aqueous phase comprises humectant, preservative, pH regulator, and optionally other components.
The moisturizer is not particularly limited as long as it is a moisturizer commonly used in the cosmetic field, and examples thereof include glycerin, propylene glycol, seaweed extract, sodium hyaluronate, aloe vera extract, luba gum oil, polyethylene/polypropylene glycol-14/7 dimethyl ether, xylitol, sorbitol, and the like.
Examples of the preservative include phenoxyethanol, ethylhexylglycerin, hexylene glycol, and pentylene glycol.
Examples of the pH adjuster include arginine, sodium hydroxide, potassium hydroxide, triethanolamine, and aminomethyl propanol.
One or more of vitamin E, Scutellariae radix extract, bisabolol, Scutellariae radix root extract, Prinsepia utilis Royle extract, ceramide, dextran, and vitamin B5 with damaged skin repairing effect can also be added into sunscreen cosmetic composition.
The organic ultraviolet absorber of the present invention is preferably polysiloxane-15, ethylhexyl triazone, diethylhexyl butamido triazone and bis-ethylhexyloxyphenol methoxyphenyl triazine.
Wherein the polysiloxane-15, the ethylhexyl triazone and the ethylhexyl butamido triazone mainly absorb ultraviolet rays in UVB wave band so as to prevent skin from being sunburned; the bis-ethylhexyloxyphenol methoxyphenyl triazine is the most effective broad-spectrum UV absorbent, can shield ultraviolet rays in UVA wave band, prevent tanning and induce skin cancer, particularly has larger absorption in the region of 330-350nm where the absorption of other three ultraviolet absorbents is very weak, is used for making up the defects of other three sunscreens, has the synergistic effect and can obtain more stable and efficient sunscreen effect.
The preferred organic UV absorbers according to the invention are preferably used in amounts which are based on the sunscreen cosmetic compositions
The total weight of the components is 150.1-10% of polysiloxane, 0.1-5% of ethylhexyl triazone, 0.1-10% of ethylhexyl butamido triazone and 0.1-10% of bis-ethylhexyl oxyphenol methoxyphenyl triazine.
The emollient of the present invention, preferably caprylic/capric triglyceride, isopropyl palmitate, and C12-15 alcohol benzoate, is an excellent solvent for the sunscreen agent, and can achieve the effect of being stable at low temperature without precipitation. Cyclopentadimethicone provides a fresh skin feel to the compositions herein.
The preferred emollients of the present invention are preferably used in an amount, relative to the total weight of the sunscreen cosmetic composition, of: 0.5-20% of caprylic/capric triglyceride, 0.5-20% of isopropyl palmitate and 0.5-20% of C12-15 alcohol benzoate.
The invention further comprises an inorganic ultraviolet blocking agent, preferably zinc oxide and titanium dioxide, wherein the zinc oxide mainly blocks UVA, and the titanium dioxide mainly blocks UVB.
The inorganic ultraviolet blocking agent is preferably used in an amount of 0.05 to 20% by weight of zinc oxide and 0.05 to 20% by weight of titanium dioxide, based on the total weight of the sunscreen cosmetic composition.
< second aspect >
A second aspect of the present invention provides a process for the preparation of a sunscreen composition comprising the step of mixing the components of the sunscreen composition. The preparation method of the sunscreen composition is simple and feasible, the raw materials are easy to obtain, and the sunscreen composition is suitable for mass production.
In some specific embodiments, the method of preparing the sunscreen composition comprises the steps of:
dissolving oil phase and water phase components at 70-90 ℃, preparing an oil phase and water phase mixture, and passing through an Ika T18 homogenizer 3000-; cooling to below 45 deg.C, and adding other components to obtain sunscreen cosmetic composition.
Further, the invention also provides application of the sunscreen composition in the sunscreen products of skin care and body care, wherein the sunscreen cosmetic comprises sunscreen milk, sunscreen lotion, sunscreen cream, sunscreen liquid, sunscreen spray, sunscreen gel, sun screen cream, sun screen lotion, sun screen cream BB cream.
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
The sunscreen compositions of examples 1-7 were prepared according to the mass percentages of the components in table 1 below.
The preparation method of the sunscreen composition comprises the following steps:
dissolving oil phase and water phase components at 70-90 ℃, preparing an oil phase and water phase mixture, and passing through an Ika T18 homogenizer at 3000-4000r/min until the oil phase and the water phase are uniformly mixed; cooling to below 45 deg.C, adding other components, and making into sunscreen cosmetic composition.
TABLE 1 sunscreen compositions of examples 1-7
The sunscreen compositions of comparative examples 1 to 6 were prepared according to the preparation methods of examples 1 to 7 according to the mass percentages of the components in table 2 below.
TABLE 2 sunscreen compositions of comparative examples 1-6
Efficacy test
Sun Protection Factor (SPF): also known as the solar protection factor, indicates how high the sunscreen product can exert the sunscreen effect. The larger the SPF value, the better the sunscreen effect. It is determined based on the Minimum Erythemal Dose (MED) of the skin. After use of the sunscreen, the minimum erythema dose of the skin increases, and the sun protection factor SPF of the sunscreen is then: SPF ═ MED of samples protected skin/MED of unprotected skin. The SPF index is useful for evaluating the protection against UVB.
Long-wave uv Protection index (Protection Factor of uva, PFA value) of sunscreen cosmetic: also known as the UVA protection index. UVA in sunlight strikes the skin, primarily producing the physiological effects of skin darkening, measured as the minimum sustained amount of darkening (MPPD). MPPD is the minimum ultraviolet irradiation dose or the minimum irradiation time required for 2-4h after irradiation to produce slight blackening on the skin at the whole irradiation site. PFA is MPPD of sample protected skin/MPPD of unprotected skin. PFA rating is based on cosmetic label identification management standard specifications.
See table 3 below for evaluation rating:
TABLE 3
| Range of PFA value | Identification |
| PFA＜2 | Unable to mark UVA protective effect |
| 2≤PFA≤3 | Mark is PA + |
| 4≤PFA≤7 | Mark is PA + |
| 8≤PFA≤15 | Mark is PA + + + |
| PFA≥16 | Mark is PA + + + + |
The test samples of the test experiment are the sunscreen emulsions prepared in examples 1-7 and comparative examples 1-6, and the sunscreen effect of the product is tested according to the sunscreen cosmetic sun protection index test method (human method) in technical standards for cosmetic safety (2015 edition), and the test results are shown in the table.
Sensory evaluation
Since most users of sunscreen are female, 39 female volunteers aged 22-40 years were selected, and all volunteers had no history of skin allergy. The volunteers can use the product according to the standard and complete the evaluation work according to the requirements by matching with the working personnel, and the system has certain expression capability and can truly reflect the feeling after use. The sunscreen milks prepared in examples 1 to 7 and comparative examples 1 to 6 were randomly distributed to volunteers, respectively, and they were allowed to use the specified sunscreen milks every day for 14 consecutive days, and the use of the sunscreen milks was evaluated as sensory evaluation. The evaluation items included greasy feel, heavy feel, and whiteness. The evaluation criteria used a score of 10, with higher scores representing higher degrees of whitening of the skin feel or appearance of the sample.
And (3) crystallization and precipitation: weighing crystal type ultraviolet absorbent (except polysiloxane-15) in oil solubility, mixing with other materials in oil phase; heating at 80-85 ℃ for 5-15 min, dissolving until the solution is clear and transparent, and cooling to 40-45 ℃ to obtain an oil phase mixture.
1. The experimental method comprises the following steps: the stability of the oil phase mixtures of examples 1 to 7 and comparative examples 1 to 6 was examined by placing the prepared compositions in an environment of 5 ℃ for 1 month and observing the precipitation.
TABLE 4 evaluation results of sunscreen compositions of examples 1-7
| Example 1 | Example 2 | Examples3 | Example 4 | Example 5 | Example 6 | Example 7 | |
| SPF | 20.7 | 20.9 | 24.6 | 46.3 | 45.3 | 49.3 | 52.8 |
| PA | ++ | ++ | ++ | +++ | +++ | +++ | +++ |
| Whether or not to crystallize out under low temperature conditions | Is that | Whether or not | Whether or not | Whether or not | Whether or not | Whether or not | Whether or not |
| Greasy feeling | Non-greasy | Greasy or greasy food | Refreshing | Greasiness | Non-greasy | Non-greasy | Non-greasy |
| Feeling of heaviness | Light and thin | Thickness and weight | Light and thin | Thickness and weight | Light and thin | Light and thin | Light and thin |
| Whiteness degree | Is transparent | Is transparent | Without whitening | Without whitening | Without whitening | Without whitening | Is transparent |
TABLE 5 evaluation results of the sunscreen compositions of comparative examples 1 to 6
| Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | Comparative example 6 | |
| SPF | 20.9 | 11.9 | 26.6 | 20.2 | 32.3 | 29.4 |
| PA | ++ | ++ | + | ++ | ++ | +++ |
| Whether or not to crystallize out under low temperature conditions | Whether or not | Whether or not | Whether or not | Whether or not | Is that | Is that |
| Greasy feeling | Non-greasy | Non-greasy | Non-greasy | Non-greasy | Non-greasy | Non-greasy |
| Feeling of heaviness | Light and thin | Light and thin | Thickness and weight | Light and thin | Light and thin | Light and thin |
| Whiteness degree | Is transparent | Without whitening | Whitening of the skin | Without whitening | Without whitening | Without whitening |
As shown in tables 4 and 5, it can be seen from the comparison between example 1 and comparative example 1 that the sunscreen efficiency of the high molecular weight chemical sunscreen agent is higher when the sunscreen effect is equivalent, and the irritation and greasy feeling brought by the sunscreen agent can be reduced by using a low amount; the data of comparative examples 2-4 show that pure titanium dioxide has better UVB resistance than zinc oxide, and zinc oxide has better UVA protection than titanium dioxide, but the addition of 10% titanium dioxide content leads to partial consumers with reduced use feeling and serious whitening, and zinc oxide has better transparency and lighter skin feeling. The data of example 2 and comparative examples 5-6 show that the SPF and PA values of the macromolecular organic sunscreen agent can be greatly improved, and the SPF and PA values are increased along with the increase of the content; meanwhile, the addition of a small amount of the cosmetic can reduce the sticky feeling of the cosmetic and improve the experience feeling; the C12-15 alcohol benzoate and caprylic/capric triglyceride have excellent solubility for crystalline form chemical sunscreen agents. As can be seen from the comparison of examples 3-6 with comparative example 1, the addition of the film-forming agent helps to form a continuous uniform film on the skin, thereby enhancing the sunscreen effect.
The data of examples 4-7 show that increasing the titanium dioxide content increases the SPF of the cosmetic, but too much results in a reduced consumer feel; the increase of the content of ethylhexyl triazone and bis-ethylhexyl phenol methoxyphenyl triazine increases the SPF value of the cosmetic, but the content is too large and needs a large amount of oil to be dissolved, so that the stickiness of the cosmetic is increased and the experience of consumers is reduced. The content of titanium dioxide in the inorganic component is beneficial to improving the SPF value, the content of zinc oxide is beneficial to improving the PA value, and the addition of the high molecular weight organic sun-screening agent can simultaneously improve the values of the titanium dioxide and the zinc oxide to form ultraviolet UVB-UVA full-range protection.
The invention provides an organic sunscreen composition only containing large molecular weight, which is formed by mixing one or a combination of a macromolecular organic ultraviolet absorbent, an inorganic ultraviolet screening agent, nano titanium dioxide and nano zinc oxide and other cosmetically acceptable components, is safe and nontoxic, and can perform photothermal conversion on absorbed ultraviolet rays while scattering the ultraviolet rays; in addition, the macromolecular organic ultraviolet absorbent has better light stability, safety and high efficiency, so that the cosmetics are easy to apply and disperse, the sticky feeling is reduced, and the application field of the cosmetics is expanded.
The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. The sun-screening composition is characterized by comprising the following substances in percentage by weight:
0.1 to 10 percent of diethyl hexyl butamido triazone,
0.1-10% of bis-ethylhexyloxyphenol methoxyphenyl triazine.
2. The sunscreen composition of claim 1, further comprising the following by weight percent: 150.1 to 10 percent of polysiloxane,
0.1-5% of ethylhexyl triazone.
3. The sunscreen composition of claim 1, further comprising a physical sunscreen;
preferably, the physical sunscreen agent is selected from one or both of zinc oxide or titanium dioxide;
preferably, the weight percentage of the physical sunscreen agent in the sunscreen composition is: 0.05-20% of zinc oxide and 0.05-20% of titanium dioxide;
preferably, the physical sunscreen is a surface treated physical sunscreen;
preferably, the surface treatment is a treatment with triethoxycaprylylsilane as a surface treatment agent.
4. The sunscreen composition of claim 1 further comprising one or more of an emulsifier, a film former, an emollient, a thickener, a humectant, a chelating agent, a preservative, a skin conditioner, an excipient, a pH adjuster, a solvent;
preferably, the emulsifier is selected from one or more of PEG-9 polydimethylsiloxyethyl dimethicone, polyglycerol-3 polydimethylhydroxyethyldimethicone, lauryl polyethylene glycol/polypropylene glycol-18/18-dimethicone, PEG-10 dimethicone, polyglycerol-3 polyricinoleate, polyglycerol-3 diisostearate;
preferably, the emulsifier is selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone and PEG-10 dimethicone.
5. The sunscreen composition of claim 4 wherein said film former is selected from one or more of trimethylsiloxysilicate, polyurethane, hydrogenated polycyclopentadiene;
preferably, the film-forming agent is selected from trimethylsiloxysilicate.
6. The sunscreen composition of claim 4 wherein said emollient is selected from one or more of the group consisting of triglycerides (ethyl hexanoate), caprylic/capric triglycerides, pentaerythritol tetra (ethyl hexanoate), butyl octanol salicylate, diethoxyethyl succinate, isododecane, cetyl ethylhexanoate, isopropyl myristate, isopropyl palmitate, diisopropyl sebacate, dibutyl adipate, C12-15 alcohol benzoate, dioctyl carbonate, coco-caprylate/caprate, dimethicone, octyl methicone, cyclopentadimethicone, phenyl trimethicone;
preferably, the emollient is selected from caprylic/capric triglyceride, isopropyl palmitate, C12-15 alcohol benzoate, cyclopentadimethylsiloxane;
preferably, the weight percentage of the emollient in the sunscreen composition is:
0.5-20% of caprylic/capric triglyceride, 0.5-20% of isopropyl palmitate and 0.5-20% of C12-15 alcohol benzoate.
7. The sunscreen composition of claim 4 wherein said thickening agent is selected from one or more of disteardimonium hectorite, silica silylate, dextrin palmitate;
preferably, the thickener is selected from disteardimonium hectorite.
8. The sunscreen composition of claim 4, wherein said pH modifier is selected from one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol.
9. Use of a sunscreen composition according to any of claims 1 to 8 in the preparation of a cosmetic;
preferably, the cosmetic is selected from any one of sunscreen lotion, sunscreen cream, sunscreen liquid, sunscreen spray, sunscreen gel, sun screen cream, sun screen lotion, and BB cream.
10. A process for the preparation of a sunscreen composition as claimed in any one of claims 1 to 8 comprising the step of mixing the components.
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| CN116115523A (en) * | 2023-02-28 | 2023-05-16 | 彭氏(惠州)实业发展有限公司 | Sun-proof gel |
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