CN117618289A

CN117618289A - Sun-screening composition and application thereof, and daily chemical product

Info

Publication number: CN117618289A
Application number: CN202311665672.XA
Authority: CN
Inventors: 刘志勇; 杨春林
Original assignee: Qingyuan Latop Fine Chemicals Ltd
Current assignee: Qingyuan Latop Fine Chemicals Ltd
Priority date: 2023-12-06
Filing date: 2023-12-06
Publication date: 2024-03-01

Abstract

The application belongs to the technical field of cosmetic production, and discloses a sunscreen composition. The sunscreen composition comprises bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazinone and diethylamino hydroxybenzoyl hexyl benzoate in a mass ratio of (1-2): (1-2), wherein the surface of at least one of the bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazinone and diethylamino hydroxybenzoyl hexyl benzoate is coated with a shell structure; the shell structure is prepared by mixing polymethylsilsesquioxane, lauroyl lysine, an HDI/trihydroxymethyl hexyl lactone cross-linked polymer, polydimethylsiloxane and triethoxy octyl silane. According to the design, on one hand, the oil dispersibility and water dispersibility of the sunscreen composition are improved, and on the other hand, the sunscreen performance of the sunscreen composition is improved to a certain extent. In addition, the application also discloses application of the sunscreen composition and a daily chemical product.

Description

Sun-screening composition and application thereof, and daily chemical product

Technical Field

The invention relates to the technical field of daily chemicals production, in particular to a sun-proof composition and application thereof as well as daily chemicals.

Background

Sunscreens are chemical substances that can enhance the sun protection effect of sun protection products. With the increasing awareness of ultraviolet injury, the importance of sun protection products in daily skin care is also becoming more important. The advent of sunscreens has provided more options and improvements for the effectiveness of sunscreening products. The main functions of the sun-screening agent are to increase the ultraviolet absorption capacity of sun-screening products, prolong the sun-screening time, improve the sun-screening index and the like. They are capable of protecting the skin from ultraviolet rays by absorbing, reflecting or scattering the ultraviolet rays.

Organic ultraviolet absorbers are a common type of sunscreen agent. They are capable of absorbing ultraviolet light and converting it into thermal energy, thereby protecting the skin from ultraviolet light. Common organic ultraviolet absorbers include oxybenzone, benzophenone, and the like. These compounds have good ultraviolet absorption properties, and can be stably present in sunscreen products, and are not easily decomposed. Nanoparticles are also a commonly used sunscreen agent. The nano particles such as titanium dioxide and zinc oxide have higher ultraviolet absorption capability, can reflect or scatter ultraviolet rays, and effectively block the invasion of the ultraviolet rays. The small size of the nanoparticles enables them to be uniformly dispersed in the sunscreen product, improving the spreadability and transparency of the sunscreen product. Antioxidants are also widely used as sunscreens in sunscreening products. Uv radiation generates a large number of free radicals, resulting in oxidative damage to skin cells. Antioxidants such as vitamin C, vitamin E, etc. can neutralize free radicals, reduce oxidative damage caused by ultraviolet rays, and protect skin from ultraviolet rays. Meanwhile, the antioxidant can also improve the stability of the sun-proof product and prolong the service life of the sun-proof product;

in addition, some anti-inflammatory agents are also used as sunscreens. Ultraviolet radiation causes skin inflammatory reaction, and causes skin redness, itching and other uncomfortable symptoms. The anti-inflammatory agent such as glycyrrhizic acid and green tea extract can inhibit inflammatory reaction, and relieve skin discomfort caused by ultraviolet. In summary, sunscreens are a class of chemicals that enhance the sunscreening effect of a sunscreen product. They can increase the ultraviolet absorption capacity of the sunscreen product, prolong the sunscreen time, and increase the sun protection index. Organic ultraviolet absorbers, nanoparticles, antioxidants, anti-inflammatory agents, and the like are common sunscreens. The application of the sun-proof products makes the sun-proof products safer and more effective, and can better protect the skin from being damaged by ultraviolet rays.

Chinese patent application 202310462255.9 discloses a high-efficiency sun-screening synergist and a sun-screening agent and a preparation method thereof, wherein the high-efficiency sun-screening synergist comprises a flavone compound, a plant extract, a copolymer and cellulose; wherein the flavone compound comprises one of troxe, rutin, quercetin, rotenone and catechin;

the plant extract comprises one or two of flos Hokkaido (Magnola Biondii) flower extract and flos Hokkaido (Magnola Biondii) bark extract;

the copolymer is acrylic ester copolymer;

the cellulose comprises one or more of microcrystalline cellulose, ethylcellulose, and ecteinascidin cellulose;

according to the scheme, the sun-screening synergistic agent is added to be synergistic with other substances in the sun-screening agent, so that the sun-screening performance of the sun-screening agent is improved, the sun-screening value of a sun-screening product is improved, and the use feeling of the sun-screening agent is improved by adding troxerutin, a flos mori extract, an acrylic ester copolymer and microcrystalline cellulose; by adding the polyglyceryl-6 stearate and polyglyceryl-behenate composition, the cetyl phosphate potassium, the inulin lauryl carbamate and other lipid emulsifying agents, microcrystalline cellulose and acrylic ester copolymers for compounding, the waterproof property of the sun-screening agent is improved, so that the sun-screening agent added with the sun-screening synergistic agent has the functions of moisturizing and relieving, high sun-screening, small irritation and certain moisturizing and red area repairing effects; at the same time, however, the structure of the sun protection synergist is not designed too much in the scheme;

chinese patent application 202110115890.0 discloses a coated sunscreen composition and a sunscreen emulsion comprised thereof, the sunscreen composition comprising the following components: 26-30 parts of ethylhexyl methoxycinnamate; 6-10 parts of diethylamino benzoyl benzoate; 3-5 parts of ethylhexyl triazone;

according to the scheme, the coating sun-screening composition is prepared by compounding ethylhexyl methoxycinnamate, hexyl diethylin hydroxybenzoate and ethylhexyl triazone according to specific parts by weight, so that the dosage of a sun-screening agent can be obviously reduced, the sun-screening agent is improved by 40-60% compared with the combination of sun-screening agents with the same content but in a non-coating state, the skin irritation can be obviously reduced, the sun-screening agent is added into a sun-screening emulsion formula, and the sun-screening emulsion is compounded with specific contents of an emollient, an emulsifier, a thickener, a common sun-screening agent, a skin conditioning agent, a humectant, a preservative and an antioxidant, so that the prepared sun-screening emulsion can obviously reduce the skin irritation on the premise of ensuring a high SPF value, and has obviously improved mildness;

according to the scheme, ethylhexyl methoxycinnamate, diethylin hydroxybenzoyl benzoate and ethylhexyl triazone are compounded, and a mixture of glycerol stearate, stearyl alcohol polyether-21, stearyl alcohol polyether-2, glycerol, hydrogenated castor oil, phenoxyethanol, methylparaben, propylparaben and water is used for coating the ethylhexyl methoxycinnamate, the diethylin hydroxybenzoyl benzoate and the ethylhexyl triazone, so that a coated sun-screening composition is obtained, the dosage of a sun-screening agent can be obviously reduced, and the irritation of skin can be obviously reduced when the sun-screening performance is improved by 40-60% compared with that of a sun-screening agent combination with the same content but in a non-coated state; meanwhile, as can be seen from the data of the examples and the comparative examples of the scheme, even under the condition that the addition amount of other substances is not changed, the problem to be solved by the scheme cannot be solved by simply changing the proportions of ethylhexyl methoxycinnamate, hexyl diethylhydroxybenzoate and ethylhexyl triazone in the core structure, and meanwhile, when the ethylhexyl triazone is absent from the core structure, the problem to be solved by the scheme cannot be solved by the scheme, and when the hexyl diethylhydroxybenzoate and the ethylhexyl triazone are absent from the core structure, the problem to be solved by the scheme cannot be solved by the scheme;

it can be seen that this solution not only requires the preparation of a sunscreen composition of the coated structure, wherein the choice of the substances concerning the core structure, the proportions of the substances of the core structure is also important, but at the same time the basic scheme of this solution is observed "the sunscreen composition comprises the following components: 26-30 parts of ethylhexyl methoxycinnamate; 6-10 parts of diethylamino benzoyl benzoate; 3-5 parts of ethylhexyl triazone ", the importance of this scheme for shell material selection is far less than for core material selection; the main purpose of the coated sun-screening composition prepared by the scheme is firstly to reduce the sun-screening performance of the sun-screening agent, namely the SPF value, and secondly, the irritation of the sun-screening agent to the skin can be reduced; however, this approach does not provide for an excessive design of the dispersibility of the sunscreen composition in sunscreens.

The problem that this scheme needs to solve: how to develop a sunscreen composition with a core-shell structure to improve the dispersion and sunscreen ability as a sunscreen composition.

Disclosure of Invention

The invention aims to provide a sun-screening composition with a core-shell structure, which improves the oil dispersibility and water dispersibility of the sun-screening composition and improves the sun-screening performance of the sun-screening composition to a certain extent through the synergistic effect of the core-shell structure and the core structure.

To achieve the above object, the present application discloses a sunscreen composition comprising, by mass, 1 to 2: 1-2: 1-2, wherein the surface of at least one of the bis-ethylhexyl oxyphenol methoxyphenyl triazine, the ethylhexyl triazone and the diethylcarbamoylhexyl benzoate is coated with a shell structure, and the shell structure is prepared by mixing polymethyl silsesquioxane, lauroyl lysine, HDI/trimethylol hexyl lactone crosslinked polymer, polydimethylsiloxane and triethoxy octyl silane;

in the shell structure, the addition amount of each component is as follows:

preferably, in the shell structure, the addition amount of each component is as follows:

preferably, the mass ratio of the shell structure to the bis-ethylhexyloxyphenol methoxyphenyl triazine and/or ethylhexyl triazone and/or diethylamino hydroxybenzoyl hexyl benzoate coated in the shell structure is 48-52: 48-52.

In addition, the application also discloses a preparation method of the sun-screening composition, which is used for preparing the sun-screening composition, and the preparation method of the sun-screening composition comprises the following steps: mixing polymethyl silsesquioxane, lauroyl lysine, HDI/trimethylol hexyl lactone crosslinked polymer, polydimethylsiloxane and triethoxy octyl silane to prepare a shell structure, coating the shell structure on the surface of at least one of bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone and diethylin hydroxybenzoyl hexyl benzoate, and mixing the bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone and diethylin hydroxybenzoyl hexyl benzoate to prepare the modified polyurethane foam.

In addition, the application also discloses application of the sun-screening composition as an active ingredient of sun-screening daily chemicals.

In addition, the application also discloses a sun-proof daily chemical product which contains the sun-proof composition.

Preferably, the sun-proof daily chemical product is in the form of cream, emulsion or spray.

The beneficial effects of this application are:

the application is characterized in that a shell structure prepared by mixing polymethyl silsesquioxane, lauroyl lysine, HDI/trimethylol hexyl lactone crosslinked polymer, polydimethylsiloxane and triethoxy octyl silane is coated on the surface of at least one of bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone and diethylhydroxybenzoyl hexyl benzoate, and then the bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone and diethylhydroxybenzoyl hexyl benzoate are mixed, so that the skin feel of the composition is finer and smoother and the composition is easier to disperse by grease, the oil dispersibility and the water dispersibility of the sun-screening composition are improved, and the sun-screening performance of the sun-screening composition is improved to a certain extent.

Detailed Description

The present invention will be described more fully hereinafter with reference to the accompanying drawings, in which specific conditions, either conventional or manufacturer-suggested, are not explicitly shown. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

The raw material information of each example is shown in table 1:

TABLE 1

A process for the preparation of a sunscreen composition:

step 1: weighing polymethylsilsesquioxane, lauroyl lysine, HDI/trimethylol hexyl lactone crosslinked polymer, polydimethylsiloxane and triethoxyoctyl silane according to the addition amount of shell structure substances in a formula, and then putting the raw materials into a beaker filled with deionized water and performing ultrasonic dispersion for 30min to obtain a dispersion;

step 2: putting the coated object into the dispersion liquid 1, heating in water bath at 80 ℃ for 3 hours, and drying to obtain coated bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone or diethylamino hydroxybenzoyl hexyl benzoate; it should be noted that, the specific coating is described in the examples;

step 3: and mixing the coated bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone or diethylamino hydroxybenzoyl hexyl benzoate with uncoated bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone or diethylamino hydroxybenzoyl hexyl benzoate to obtain the sun-screening composition.

Examples 1 to 4

A sunscreen composition having a shell structure comprising the formula shown in Table 2:

TABLE 2

It should be noted that the shell structures prepared in examples 1 to 4 are coated on the surface of bis-ethylhexyloxyphenol methoxyphenyl triazine, and the mass ratio of the shell structure to the bis-ethylhexyloxyphenol methoxyphenyl triazine is 1:1, simultaneously, the preparation method in the embodiments 1-4 comprises the steps of coating a shell structure on the surface of double-ethylhexyl oxyphenol methoxyphenyl triazine, and then mixing the double-ethylhexyl oxyphenol methoxyphenyl triazine coated with ethylhexyl triazone and diethylin hydroxybenzoyl hexyl benzoate, wherein the mass ratio of the ethylhexyl triazone, the diethylin hydroxybenzoyl hexyl benzoate and the uncoated double-ethylhexyl oxyphenol methoxyphenyl triazine is 1:1:1.

example 5

Substantially the same as in example 1, except that the shell structure was coated on the surface of ethylhexyl triazone, and the mass ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylhydroxybenzoyl benzoate to uncoated ethylhexyl triazone was 1:1:1.

example 6

Substantially the same as in example 1, except that the shell structure was coated on the surface of hexyl diethylhydroxybenzoyl benzoate, and the mass ratio of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and uncoated hexyl diethylhydroxybenzoyl benzoate was 1:1:1.

example 7

Substantially the same as in example 1, except that the shell structures were coated on the surfaces of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylhydroxybenzoyl benzoate, respectively, and the ratio of the total mass of the shell structures to the total mass of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylhydroxybenzoyl benzoate was 1:1, simultaneously, the mass ratio of the uncoated bis-ethylhexyloxyphenol methoxyphenyl triazine, the uncoated ethylhexyl triazone and the uncoated diethylcarbamoylhexyl benzoate is 1:1:1.

example 8

Substantially the same as in example 1, except that the mass ratio of the core structure and the shell structure was 48:52.

example 9

Substantially the same as in example 1, except that the mass ratio of the core structure and the shell structure was 52:48.

example 10

Substantially the same as in example 1, except that the mass ratio of uncoated bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylhydroxybenzoyl hexyl benzoate was 1:2:1.

example 11

Substantially the same as in example 1, except that the mass ratio of uncoated bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylhydroxybenzoyl hexyl benzoate was 2:1:2.

comparative examples 1 to 5

A composition substantially the same as in example 1 except that the formula of the shell structure is as shown in table 3:

TABLE 3 Table 3

Comparative examples 6 to 10

A composition substantially the same as in example 1 except that the shell structure was formulated as shown in table 4:

TABLE 4 Table 4

Comparative example 11

Substantially the same as in example 1, except that ethylhexyl methoxycinnamate was used instead of bis-ethylhexyl oxyphenol methoxyphenyl triazine, and the shell structure was coated onto the surface of ethylhexyl methoxycinnamate, while the mass ratio of the uncoated ethylhexyl methoxycinnamate to the hexyl diethylhydroxybenzoylbenzoate, ethylhexyl triazone was 1:1:1.

performance test:

1. dispersibility test

The prepared compositions of examples and comparative examples were added to an aqueous phase solvent and an oil phase solvent, respectively, and the compositions were tested for dispersibility in the aqueous phase and the oil phase, respectively, and the results are shown in table 5:

TABLE 5

2. Sun protection effect test

(1) Sun Protection Factor (SPF): also known as the sun protection factor, indicates the level of sun protection efficacy that the sun protection product can exert; the larger the SPF value is, the better the sun-proof effect is; it is determined based on the Minimum Erythema Dose (MED) of the skin. The minimum erythema dose of the skin increases after the sun protection product is used, and the sun protection factor SPF of the sun protection product is as follows: SPF = lowest erythema dose (after sunscreens)/lowest erythema dose (before sunscreens), SPF index is suitable for evaluating the protective effect on UVB.

(2) Sun-protection cosmetics long wave ultraviolet protection index (PFA value): also known as UVA protection index. UVA in sunlight irradiates the skin, mainly producing a physiological effect of skin darkening, which is measured in minimum sustained darkening amount (MPPD). MPPD is the minimum ultraviolet radiation dose or minimum irradiation time required to produce a slight darkening of the skin across the illuminated area 2-4 hours after irradiation. The sunscreen effect of the products prepared in accordance with the cosmetic safety Specification (2015 edition) Sun protection cosmetic Sun protection index test method (human body method) test examples and comparative examples is shown in Table 6.

The sunscreen compositions prepared in examples and comparative examples were mixed with oil phase ingredients including isododecane, diisopropyl sebacate, bis-ethylhexyloxyphenol methoxyphenyl triazine/ethylhexyl triazone/diethylhydroxybenzoyl hexyl benzoate, C12-15 alcohol benzoate, homosalate, octocrylene, ethylhexyl methoxycinnamate to prepare a finished sunscreen product and tested.

Table 6: sun protection test results

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Analysis of results:

1. it can be seen from examples 1 to 4 that, when the addition amount of each composition of the shell layer is changed, neither the water dispersibility nor the oil dispersibility of the sunscreen composition is significantly changed, and the sun-screening ability of the subsequently produced sunscreen agent is not significantly fluctuated, but example 1 has a certain advantage over examples 2 to 4 in terms of water dispersibility, oil dispersibility and sun-screening ability of the subsequently produced sunscreen agent, and therefore, it is considered that the ratio of the shell layer content in example 1 is more advantageous than examples 2 to 4;

2. it can be seen from examples 5 to 7 that when examples 5 and 6 use ethylhexyl triazone, diethylcarbamoylbenzoate instead of bis-ethylhexyloxyphenol methoxyphenyl triazine as the core structure coated by the shell structure, the three examples have little variation in dispersion properties, but some fluctuation in sun-screening ability of the subsequently prepared sunscreens is generated, and at the same time, when example 7 coated the ethylhexyl triazone, diethylcarbamoylbenzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine simultaneously, the sun-screening effect is significantly improved compared with example 1;

3. it can be seen from examples 1 and comparative examples 1 to 5 that, when any one of the materials in the shell structure is omitted, the dispersibility of the sunscreen agent itself and the sun-screening ability of the subsequently produced sunscreen agent are significantly reduced, and thus, it can be seen that any one of the components is indispensable in the shell structure of the sun-screening composition;

4. it can be seen from example 1 and comparative examples 6 to 10 that when any of the shell structures is replaced with another substance, there is a significant decrease in the dispersibility of the sunscreen itself and in the sun protection ability of the subsequently produced sunscreen, and therefore, it can be seen that any of the components in the shell structure of the sunscreen composition is not replaceable.

5. It can be seen from example 1 and comparative example 11 that the sunscreen composition still does not exhibit good sunscreen effect when the bis-ethylhexyl oxyphenol methoxyphenyl triazine in the bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone, and diethylhydroxybenzoyl hexyl benzoate is replaced.

Claims

1. A sunscreen composition, characterized in that it comprises, in mass ratio, 1-2: 1-2: 1-2, wherein the surface of at least one of the bis-ethylhexyl oxyphenol methoxyphenyl triazine, the ethylhexyl triazone and the diethylcarbamoylhexyl benzoate is coated with a shell structure, and the shell structure is prepared by mixing polymethyl silsesquioxane, lauroyl lysine, HDI/trimethylol hexyl lactone crosslinked polymer, polydimethylsiloxane and triethoxy octyl silane;

in the shell structure, the addition amount of each component is as follows:

2. the composition according to claim 1, wherein the shell structure comprises the following components:

3. a sunscreen composition according to claim 1, wherein the mass ratio of said shell structure to bis-ethylhexyloxyphenol methoxyphenyl triazine and/or ethylhexyl triazone and/or diethylcarbamoylhexyl benzoate coated in the shell structure is from 48 to 52: 48-52.

4. A process for the preparation of a sunscreen composition according to any one of claims 1 to 3, said process comprising: mixing polymethyl silsesquioxane, lauroyl lysine, HDI/trimethylol hexyl lactone crosslinked polymer, polydimethylsiloxane and triethoxy octyl silane to prepare a shell structure, coating the shell structure on the surface of at least one of bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone and diethylin hydroxybenzoyl hexyl benzoate, and mixing the bis-ethylhexyl oxyphenol methoxyphenyl triazine, ethylhexyl triazone and diethylin hydroxybenzoyl hexyl benzoate to prepare the modified polyurethane foam.

5. Use of a sunscreen composition according to any of claims 1-3 as an active ingredient of a sun-care daily chemical.

6. A sun-care daily chemical product comprising the sun-care composition according to any one of claims 1 to 3.

7. The sun-care daily chemical product according to claim 6, wherein the sun-care daily chemical product is in the form of cream, emulsion or spray.