CN115300417A - Sunscreen cream suitable for children and sensitive muscles and preparation method thereof - Google Patents
Sunscreen cream suitable for children and sensitive muscles and preparation method thereof Download PDFInfo
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- CN115300417A CN115300417A CN202211130331.8A CN202211130331A CN115300417A CN 115300417 A CN115300417 A CN 115300417A CN 202211130331 A CN202211130331 A CN 202211130331A CN 115300417 A CN115300417 A CN 115300417A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Abstract
The invention provides sunscreen cream suitable for children and sensitive muscles and a preparation method thereof. The sunscreen cream suitable for children and sensitive muscles comprises an organic sunscreen agent, an emulsifier, a thickener, a humectant, grease and a solvent; the emulsifier comprises a water-soluble emulsifier and an oil-soluble emulsifier, and the thickener comprises an aqueous thickener and an emulsifying thickener. The organic sunscreen agent is embedded in the polyhedral structure shell, so that the safety problem caused by the penetration of the organic sunscreen agent into the skin is avoided. Meanwhile, due to the polyhedral structure wrapping the shell, the ultraviolet-ray scattering effect can be achieved, the ultraviolet-ray scattering effect can be uniformly dispersed on the surface of the skin, and the light protection capability of the sunscreen cream can be improved under the condition that the content of the organic sunscreen agent is equal. On the components of the sunscreen cream, mild components are applied to ensure the safety of the product. In terms of process, the low-temperature addition process ensures the safety and stability of the product.
Description
Technical Field
The invention belongs to the technical field of sunscreen, and particularly relates to sunscreen containing a coated organic sunscreen and a preparation method thereof, in particular to sunscreen suitable for children and sensitive muscles and a preparation method thereof.
Background
The sunscreen cosmetic is sunscreen cream with effects of changing ultraviolet and relieving skin injury caused by sun exposure. The main component of sunscreen products that functions to block ultraviolet light is sunscreens.
Sunscreens are largely divided into two main classes:
1. an inorganic sunscreen agent. Inorganic sunscreens are a class of white inorganic mineral powders, of which only titanium dioxide and zinc oxide are permitted in the 2015 edition "safety and technical Specification for sunscreens". Such a sunscreen agent is also called an ultraviolet screening agent because of its physical screening effect, and has the advantages of high safety and good stability. The nano-scale inorganic sunscreen agent has the advantages of strong sunscreen capacity and good transparency because the particle diameter of the inorganic sunscreen agent is below tens of nanometers, but has the defects of easy agglomeration, poor dispersibility, easy generation of free radicals while absorbing ultraviolet rays and the like, so the particle surface of the inorganic sunscreen agent needs to be modified to solve the defects, and the requirement on the research and development capacity of manufacturers is high.
2. An organic sunscreen agent. Such sunscreens are a class of organic compounds having a better absorption of ultraviolet rays, also known as ultraviolet absorbers. The substance can selectively absorb ultraviolet rays and convert the light energy of the absorbed ultraviolet rays into heat energy, and the structure of the substance is not changed. 25 approved organic sunscreens are listed in the sun cream safety technical specification of 2015 edition, and the use conditions (mainly the dosage) are regulated. Common examples include p-methoxycinnamates, camphor derivatives, benzotriazoles, and octocrylene.
The photoprotective performance indicators characterizing sunscreen cosmetics are SPF value and PFA value:
the SPF (Sun Protection Factor) value is a performance indicator of sunscreens to protect skin from erythema solaris, and is an assessment of UVB Protection, known as the Sun Protection Factor or Sun Protection Factor. When the actually measured SPF value of the sunscreen is less than 2, the sunscreen effect cannot be identified; when the SPF value is more than or equal to 2 and less than or equal to 50, marking an actual numerical value, wherein the larger the numerical value is, the better the protection effect is; when the SPF value is more than 50, no specific numerical value is marked, and the values are marked as 50+.
The SPF value is an assessment of the protective effect of a product against UVB and corresponds to a PFA (protection factor of UVA) value, which reflects the protective effect of a product against UVA. When the actually measured PFA value of the sun-screening product is less than 2, the UVA protection effect cannot be identified; when the PFA value is more than or equal to 2 and less than 16, the corresponding PA grade can be identified according to the value.
The sunscreen agents of the commercial sunscreen cosmetic compositions fall into the following classes:
(1) A pure inorganic sunscreen agent. Usually titanium dioxide and zinc oxide. However, because a thick white layer is deposited on the surface of the skin, pores are easy to be blocked, normal secretion of sebaceous glands and sweat glands is influenced, and the sunscreen is easy to fall off, so that the sunscreen with the whitening effect is often contained in the sunscreen.
(2) A pure organic sunscreen agent. A variety of sunscreens are often used in combination to enhance the sunscreen effect. Compared with inorganic sunscreens, organic sunscreens have more potential safety hazards, such as skin irritation, skin allergy and the like, but most of the sunscreen capacity of organic sunscreens is stronger than that of inorganic sunscreens.
(3) Mixing organic and inorganic sun-screening agents. Because the two types of sunscreens have synergistic effect when mixed, the total use amount of the sunscreens can be reduced. The disadvantages of the sunscreen itself remain.
In addition to the above combinations, the trend in recent years toward the development of sunscreen agents is to make them large-molecular. This "500 daltons (D) rule" derives from the field of transdermal drug delivery, i.e., the sunscreen should have a molecular weight above 500D so that it does not penetrate into the skin. However, the safety of the sunscreen cannot be simply considered from the aspect of molecular weight, and other factors influencing the safety cannot be ignored.
In order to obtain sunscreen cosmetics with higher SPF and PFA values, increasing the amount of sunscreen agent used is a common approach, but the potential safety hazard and skin feel disadvantages caused thereby cause great trouble to developers.
Therefore, it is an urgent problem to provide a sunscreen cosmetic having excellent sunscreen effect, skin feel and safety.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a sunscreen cream suitable for children and sensitive muscles and a preparation method thereof. The sunscreen cream suitable for children and sensitive muscles provided by the invention not only has an excellent sunscreen effect, but also has excellent skin feel and safety.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a sunscreen cream suitable for children and sensitive muscles, comprising a coating organic sunscreen, an emulsifier, a thickener, a humectant, a grease, and a solvent; the emulsifier comprises a water-soluble emulsifier and an oil-soluble emulsifier, and the thickener comprises an aqueous thickener and an emulsifying thickener.
In the invention, the organic sunscreen agent is embedded in the shell with the polyhedral structure, so that the safety problem caused by the penetration of the organic sunscreen agent into the skin is avoided. Meanwhile, due to the polyhedral structure wrapping the shell, the ultraviolet light can be scattered and uniformly dispersed on the surface of the skin, and the light protection capability of the sunscreen cosmetic can be improved under the condition that the contents of the organic sunscreen agents are equal. On the components of the sunscreen cream, mild components are applied to ensure the safety of the product. In terms of process, the low-temperature addition process ensures the safety and stability of the product.
In the present invention, in the case of the present invention, the sunscreen cream suitable for children and sensitive muscles comprises 1-30 parts (such as 1 part, 3 parts, 5 parts, 7 parts, 9 parts, 13 parts, 15 parts, 19 parts, 23 parts, 25 parts, 29 parts, 30 parts and the like) of wrapped organic sunscreen agent, 0.1-5 parts (such as 0.1 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts and the like) of water-soluble emulsifier, 0.05-2 parts (such as 0.05 part, 0.5 part, 1 part, 1.5 parts, 2 parts and the like) of oil-soluble emulsifier, 0.05-1 part (such as 0.05 part, 0.1 part, 0.05 part, 2 parts and the like) of water-based thickener, and the like 0.3 part, 0.5 part, 0.7 part, 0.9 part, 1 part, etc.), an emulsion thickener 0.1 to 5 parts (for example, 0.1 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, etc.), a humectant 0.1 to 15 parts (for example, 0.1 part, 1 part, 3 parts, 5 parts, 7 parts, 9 parts, 11 parts, 13 parts, 15 parts, etc.), an oil or fat 0.1 to 15 parts (for example, 0.1 part, 1 part, 3 parts, 5 parts, 7 parts, 9 parts, 11 parts, 13 parts, 15 parts, etc.) and a solvent 30 to 80 parts (for example, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, etc.).
In the invention, the shell for wrapping the organic sunscreen agent comprises any one of polysiloxane substances, silica, phosphorus ester substances, polymethyl methacrylate substances or cellulose polymers or a combination of at least two of the substances;
preferably, the polysiloxane comprises any one of polysiloxane-11, polysiloxane-13, polysiloxane-14 or polysiloxane-15 or a combination of at least two thereof.
Preferably, the phospholipid material comprises any one of or a combination of at least two of phospholipid, lecithin or hydrogenated lecithin.
Preferably, the polymethylmethacrylate species comprises polymethylmethacrylate and/or a polymethylmethacrylate-based crosslinked polymer.
Preferably, the cellulosic polymer species comprises any one of cellulose acetate butyrate, cellulose acetate propionate or cellulose acetate or a combination of at least two thereof.
Preferably, the organic sunscreen agent in the encapsulated organic sunscreen agent comprises any one of butyl methoxydibenzoylmethane, octocrylene, ethylhexyl methoxycinnamate or hexyl diethylaminobenzoyl benzoate or a combination of at least two thereof.
Preferably, the mass ratio of the shell wrapping the organic sunscreen agent to the organic sunscreen agent is (1-70) to (1-60);
wherein "1-70" can be 1, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, etc.;
"1-60" can be 1, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, etc.
Preferably, the encapsulated organic sunscreen comprisesOB-S, silamoma REA (S) or AvoCap TM Or a combination of at least two thereof.
Preferably, the encapsulated organic sunscreen comprisesOB-S of The shell of OB-S comprises silica, saidOB-S encapsulated organic sunscreens include butyl methoxydibenzoylmethane and octocrylene.
Preferably, the encapsulated organic sunscreen comprises silaoma REA (S) whose shell comprises polysiloxane-14, and the silaoma REA (S) encapsulated organic sunscreen comprises butyl methoxydibenzoylmethane and octocrylene.
The Silamoma EP (S) also comprises water, butanediol, phenoxyethanol and EDTA disodium.
Preferably, the encapsulated organic sunscreen comprises AvoCap TM Said AvoCap TM Comprises cellulose acetate, said AvoCap TM Encapsulated organic sunscreens include butyl methoxydibenzoylmethane andoctocrilene.
In the present invention, the water-soluble emulsifier includes any one or a combination of at least two of a phospholipid emulsifier, an amino acid emulsifier, and a sucrose ester emulsifier, and is preferably a phospholipid emulsifier, an amino acid emulsifier, and a sucrose ester emulsifier.
Preferably, the mass ratio of the phospholipid emulsifier to the amino acid emulsifier to the sucrose ester emulsifier is (1-3): 0.05-0.15): 0.15-0.25;
wherein "1-3" can be 1, 1.3, 1.6, 1.9, 2.1, 2.4, 2.7, 3, etc.;
"0.05-0.15" can be 0.05, 0.07, 0.09, 0.11, 0.13, 0.15, etc.;
"0.15-0.25" may be 0.15, 0.17, 0.19, 0.21, 0.23, 0.25, etc.
Preferably, the phospholipid emulsifier comprises hydrogenated lecithin.
Preferably, the phospholipid emulsifier is selected from any one or a combination of at least two of phytompo-PP, compsite-PC, compsite-C3, phytompo-C5, phytompo-SP, phytompo-SC or Compsite-C4.
Preferably, said phytompo-PP comprises hydrogenated lecithin and phytosterols.
Preferably, the Composite-PC comprises hydrogenated lecithin and cholesterol.
Preferably, the Composite-C3 comprises hydrogenated lecithin, cholesterol, ceramide NS/ceramide NG, ceramide NP, and ceramide AP.
Preferably, said phytompo-C5 comprises hydrogenated lecithin, phytosterols, ceramide NS/ceramide NG, ceramide NP, hydroxypalmitoyl sphinganine and ceramide AP.
Preferably, the phytompo-SP comprises hydrogenated lecithin, phytosterols, glycerol and butylene glycol.
Preferably, said phytompo-SC comprises hydrogenated lecithin, phytosterols, glycerol, butylene glycol, ceramide NS/ceramide NG, ceramide NP and ceramide AP.
Preferably, the Composite-C4 comprises hydrogenated lecithin, cholesterol, ceramide NS/ceramide NG, ceramide NP, hydroxypalmitoyl dihydrosphingosine, and ceramide AP.
Preferably, the amino acid-based emulsifier is selected from surfactin sodium and/or inulin lauryl carbamate.
Preferably, the sucrose ester emulsifier is selected from any one of sucrose palmitate, sucrose myristate, sucrose laurate or sucrose oleate, or a combination of at least two thereof.
Preferably, the oil-soluble emulsifier is selected from polyglycerine type emulsifiers.
Preferably, the polyglycerol-based emulsifier is selected from any one of or a combination of at least two of polyglycerol-3 diisostearate, polyglycerol-2 oleate, polyglycerol-2 triisostearate, polyglycerol-4 isostearate, polyglycerol-3 polyricinoleate, polyglycerol-3 ricinoleate or polyhydroxystearic acid.
In the present invention, the aqueous thickener is selected from any one or a combination of at least two of carbomer, acrylic acid/C10-30 alkanol acrylate crosspolymer, xanthan gum, magnesium aluminum silicate, lithium magnesium silicate, sodium polyacryloyldimethyltaurate, microcrystalline cellulose, carob bean gum, ruga carrageenan extract, sodium polyacrylate, hydroxyethyl cellulose, sodium polyacrylate grafted starch, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, sodium acrylate/sodium acryloyldimethyltaurate copolymer, or polyacrylate-13.
Preferably, the emulsifying thickener is selected from any one of or a combination of at least two of sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylamide, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, acrylamide and acrylamide copolymer, polyisobutylene, xanthan gum, ammonium acryloyldimethyl taurate/VP copolymer or acrylic acid (ester) -based cross-linked polymer-2.
Preferably, the emulsifying thickener is selected from any one or a combination of at least two of SIMULGEL EG, SEPIGEL 305, SEPINOV EMT 10, SEPIPLUS 265, SIMULGEL NS, SEPIPLUS 400, SEPINOV WEO, SIMULGEL INS 100, SILIGEL, aristoflex AVC, or AQUA KEEP 10 SH-NFC.
Preferably, the SIMULGEL EG comprises sodium acrylate/sodium acryloyldimethyl taurate copolymer, water, isohexadecane, polysorbate-80, and sorbitan oleate.
Preferably, the SEPIGEL 305 comprises water, polyacrylamide, C13-14 isoparaffin, and laureth-7.
Preferably, the SEPINOV EMT 10 comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sorbitan isostearate, polysorbate-60 and water.
Preferably, the SEPIPLUS 265 includes an acrylamide and acrylamide copolymer, polyisobutylene, and polysorbate 20.
Preferably, the SIMULGEL NS comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, squalane, polysorbate-60, water and sorbitan isostearate.
Preferably, the SEPIPLUS 400 comprises water, polyacrylate-13, polyisobutylene, polysorbate-20, and sorbitan isostearate.
Preferably, the SEPINOV WEO comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sorbitan isostearate and water.
Preferably, the SIMULGEL INS 100 comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-60, sorbitan isostearate and water.
Preferably, the SILIGEL comprises xanthan gum, lecithin, sclerotium rolfsii gum, pullulanase, and silica.
Preferably, the Aristoflex AVC comprises an acrylyldimethyl ammonium taurate/VP copolymer, water and t-butanol.
Preferably, the AQUA KEEP 10SH-NFC includes cross-linked polymer-2 sodium acrylate, silica and water.
In the present invention, the humectant is selected from any one or a combination of at least two of glycerin, hydroxyethyl urea, betaine, propylene glycol, methyl propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, octylene glycol, ethylhexylglycerin, polyethylene glycols, or sorbitol, and preferably glycerin, hydroxyethyl urea, and betaine.
Preferably, the mass ratio of the glycerol to the hydroxyethyl urea to the betaine is (3-5) to (1-3);
wherein "3-5" can be 3, 3.5, 4, 4.5, 5, etc.;
"1-3" can be 1, 1.3, 1.6, 1.9, 2.3, 2.6, 2.9, 3, etc.
Preferably, the oil is selected from any one or a combination of at least two of polydimethylsiloxane, butanediol dicaprylate/dicaprate, squalane, hydrogenated polyisobutene, phytosterols, behenyl alcohol, cetearyl alcohol, cetyl alcohol, C12-15 alcohol benzoate, coco alcohol-caprylate/caprate, octyl methicone, isononyl isononanoate or butyl octanol salicylate, preferably polydimethylsiloxane, coco alcohol-caprylate/caprate and cetearyl alcohol.
Preferably, the mass ratio of the polydimethylsiloxane, the coco-caprylate/caprate and the cetearyl alcohol is (2-4): (1-3): (0.1-0.5);
wherein "2-4" can be 2, 2.3, 2.6, 2.9, 3.3, 3.6, 3.9, 4, etc.;
"1-3" can be 1, 1.3, 1.6, 1.9, 2.3, 2.6, 2.9, 3, etc.;
"0.1-0.5" may be 0.1, 0.2, 0.3, 0.4, 0.5, etc.
In the present invention, the sunscreen cream suitable for children and sensitive muscles further comprises 0.01 to 1 part (for example, 0.01 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.7 part, 0.9 part, 1 part, etc.) of an antioxidant selected from any one or a combination of at least two of tocopherol, butylated hydroxytoluene, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate), tris (tetramethylhydroxypiperidinol) citrate or tert-butylhydroquinone, preferably tocopherol, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and tert-butylhydroquinone, in parts by weight.
Preferably, the mass ratio of the tocopherol to the pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and tert-butylhydroquinone is (0.05-0.15): (0.05-0.15);
wherein "0.05-0.15" may be 0.05, 0.08, 0.09, 0.11, 0.13, 0.15, etc.
Preferably, the sunscreen cream suitable for children and sensitive muscles further comprises 0.01-1 part (for example, 0.01 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.7 part, 0.9 part, 1 part and the like) of a pH regulator by weight, wherein the pH regulator comprises any one or a combination of at least two of citric acid, sodium citrate, disodium hydrogen phosphate or sodium dihydrogen phosphate.
Preferably, the solvent comprises water.
In a second aspect, the present invention provides a process for the preparation of a sunscreen suitable for use on children and sensitive muscles according to the first aspect, comprising the steps of:
(1) Mixing a solvent, a water-soluble emulsifier, an aqueous thickener and a humectant to obtain a phase A; mixing oil and fat with an oil-soluble emulsifier to obtain a phase B;
(2) Mixing the phase A and the phase B obtained in the step (1), and homogenizing to obtain a phase C;
(3) And (3) mixing the phase C obtained in the step (2), the emulsifying thickener and the wrapping organic sunscreen to obtain the sunscreen cream suitable for children and sensitive muscles.
In the present invention, in the step (1), the mixing temperature is 50 to 70 ℃ (for example, 50 ℃, 52 ℃, 54 ℃, 56 ℃, 58 ℃,60 ℃, 62 ℃, 64 ℃, 66 ℃, 68 ℃,70 ℃ and the like) in the operation of obtaining the phase A.
Preferably, in the step (1), the mixing temperature in the operation of obtaining the phase B is 50-70 ℃ (for example, 50 ℃, 52 ℃, 54 ℃, 56 ℃, 58 ℃,60 ℃, 62 ℃, 64 ℃, 66 ℃, 68 ℃,70 ℃ and the like can be adopted).
Preferably, in the step (1), the operation of obtaining phase B further comprises an antioxidant.
In the present invention, in the step (2), the temperature for homogenization is 50 to 70 ℃ (for example, 50 ℃, 52 ℃, 54 ℃, 56 ℃, 58 ℃,60 ℃, 62 ℃, 64 ℃, 66 ℃, 68 ℃,70 ℃ and the like can be used).
Preferably, in step (3), the temperature of the mixing is 25-35 deg.C (for example, 25 deg.C, 27 deg.C, 29 deg.C, 31 deg.C, 33 deg.C, 35 deg.C, etc.).
Preferably, in the step (3), the mixing further comprises a pH adjuster.
Compared with the prior art, the invention has the following beneficial effects:
(1) The invention adopts the coated organic sunscreen agent which comprises a polyhedral structure shell and an embedded organic sunscreen agent, thereby avoiding the safety problem caused by the penetration of the organic sunscreen agent into the skin. Meanwhile, due to the polyhedral structure of the coating shell, the ultraviolet scattering effect can be achieved, the ultraviolet can be uniformly dispersed on the surface of the skin, the photodegradation of the coated organic sunscreen agent can be relieved, and the light protection capability of the sunscreen cream can be improved under the condition that the content of the organic sunscreen agent is equal.
(2) According to the invention, the mild water-soluble emulsifier, the mild oil-soluble emulsifier, the mild water-soluble thickener, the mild emulsifying thickener, the mild humectant and the mild grease are adopted, so that no stimulus source except for organic sun protection is brought, and the components are mutually matched to quickly form a layer of sunscreen protective film on the surface of skin, so that the use efficiency of the sunscreen is improved, and the use amount of the sunscreen is saved; and the sunscreen cream can be uniformly dispersed on the surface of the skin, and the sunscreen effect is improved.
(3) In the invention, the organic sunscreen agent is wrapped by adopting a low-temperature adding process, so that the shell is not influenced by high temperature, and the organic sunscreen agent is not separated out.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The sources of the components in the invention are as follows:
example 1
The embodiment provides a sunscreen cream suitable for children and sensitive muscles, which comprises the following components in parts by weight:
the preparation method of the sunscreen cream suitable for children and sensitive muscles comprises the following steps:
(1) Mixing a solvent, a water-soluble emulsifier, an aqueous thickener and a humectant at 60 ℃ to obtain a phase A; mixing oil, antioxidant and oil-soluble emulsifier at 60 deg.C to obtain phase B;
(2) Mixing the phase A and the phase B obtained in the step (1), and homogenizing at 60 ℃ to obtain a phase C;
(3) And (3) mixing the phase C obtained in the step (2), an emulsifying thickener, a coating organic sunscreen agent and a pH regulator at 30 ℃ to obtain the sunscreen cream suitable for children and sensitive muscles.
Example 2
The embodiment provides a sunscreen cream suitable for children and sensitive muscles, which comprises the following components in parts by weight:
the preparation method of the sunscreen cream suitable for children and sensitive muscles comprises the following steps:
(1) Mixing a solvent, a water-soluble emulsifier, an aqueous thickener and a humectant at 50 ℃ to obtain a phase A; mixing oil, antioxidant and oil-soluble emulsifier at 50 deg.C to obtain phase B;
(2) Mixing the phase A and the phase B obtained in the step (1), and homogenizing at 50 ℃ to obtain a phase C;
(3) And (3) mixing the phase C obtained in the step (2), an emulsifying thickener, a coating organic sunscreen agent and a pH regulator at 25 ℃ to obtain the sunscreen cream suitable for children and sensitive muscles.
Example 3
The embodiment provides a sunscreen cream suitable for children and sensitive muscles, which comprises the following components in parts by weight:
the preparation method of the sunscreen cream suitable for children and sensitive muscles comprises the following steps:
(1) Mixing a solvent, a water-soluble emulsifier, an aqueous thickener and a humectant at 70 ℃ to obtain a phase A; mixing oil, antioxidant and oil-soluble emulsifier at 70 deg.C to obtain phase B;
(2) Mixing the phase A and the phase B obtained in the step (1), and homogenizing at 70 ℃ to obtain a phase C;
(3) And (3) mixing the phase C obtained in the step (2), an emulsifying thickener, a coating organic sunscreen agent and a pH regulator at 35 ℃ to obtain the sunscreen cream suitable for children and sensitive muscles.
Example 4
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that Composite-PC is absent from the water-soluble emulsifier, the weight fraction of sodium surfactin is increased to 0.76 parts, the weight fraction of sucrose laurate is increased to 1.54 parts, and the other components and the preparation method thereof are the same as in example 1.
Example 5
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that the water-soluble emulsifier lacks sodium surfactin, the Composite-PC weight fraction is increased to 2.09 parts, the sucrose laurate weight fraction is increased to 0.21 part, and the other components and their preparation method are the same as example 1.
Example 6
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that sucrose laurate is absent from the water-soluble emulsifier, the Composite-PC weight fraction is increased to 2.19 parts, the surfactin sodium weight fraction is increased to 0.11 parts, and the other components and the preparation method thereof are the same as in example 1.
Example 7
This example provides a sunscreen cream suitable for children and sensitive muscles, which differs from example 1 only in that the moisturizer does not contain glycerin, the weight part of hydroxyethyl urea is increased to 4 parts, the weight part of betaine is increased to 4 parts, and other components and the preparation method thereof are the same as example 1.
Example 8
This example provides a sunscreen cream suitable for children and sensitive muscles, which differs from example 1 only in that the moisturizer does not contain hydroxyethyl urea, the weight part of glycerin is increased to 5.3 parts, the weight part of betaine is increased to 2.7 parts, and the other components and the preparation method thereof are the same as example 1.
Example 9
This example provides a sunscreen cream suitable for children and sensitive muscles, which differs from example 1 only in that the moisturizer does not contain betaine, the weight part of glycerin is increased to 5.3 parts, the weight part of hydroxyethyl urea is increased to 2.7 parts, and the other components and the preparation method thereof are the same as example 1.
Example 10
This example provides a sunscreen cream suitable for children and sensitive muscles, which differs from example 1 only in that the oil does not contain dimethicone, the part by weight of coco-caprylate/caprate is increased to 4.6 parts, the part by weight of cetearyl alcohol is increased to 0.7 part, and the other components and the preparation method thereof are the same as example 1.
Example 11
This example provides a sunscreen cream suitable for children and sensitive muscles, which differs from example 1 only in that the oil does not contain coco-caprylate/caprate, the part by weight of dimethicone is increased to 4.8 parts, the part by weight of cetearyl alcohol is increased to 0.5 part, and the other components and the preparation method thereof are the same as example 1.
Example 12
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that the oil does not contain cetearyl alcohol, the part by weight of dimethicone is increased to 3.18 parts, the part by weight of coco-caprylate/caprate is increased to 2.12 parts, the other components and the method of preparation are the same as in example 1.
Example 13
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that the antioxidant does not contain tocopherol, the weight part of pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) is increased to 0.15 parts, the weight part of tert-butylhydroquinone is increased to 0.15 parts, and the other components and the preparation method thereof are the same as in example 1.
Example 14
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that pentaerythritol tetrakis (di-tert-butylhydroxyhydrocinnamate) is not included in the antioxidant, increasing the weight fraction of tocopherol to 0.15 parts, increasing the weight fraction of tert-butylhydroquinone to 0.15 parts, the other components and the preparation method thereof are the same as in example 1.
Example 15
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that the antioxidant does not contain tert-butylhydroquinone, the weight part of tocopherol is increased to 0.15 part, the weight part of pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) is increased to 0.15 part, and the other components and the preparation method thereof are the same as in example 1.
Example 16
This example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that the temperature for mixing in step (3) is 60 ℃, and the other components and the preparation method thereof are the same as in example 1.
Comparative example 1
This comparative example provides a sunscreen suitable for use on children and sensitive muscles, differing from example 1 only in not containing an encapsulated organic sunscreenOB-S, containing 7.8 parts of octocrylene and 2.34 parts of butyl methoxy dibenzoylmethane, the weight part of water was increased to 71.53 parts, and the other components and the preparation method thereof were the same as in example 1.
Comparative example 2
This comparative example provides a sunscreen cream suitable for children and sensitive muscles, differing from example 1 only in that the emulsion thickener (SEPINOV EMT 10 and AQUA KEEP 10 SH-NFC) is not included, the weight fraction of water is increased to 55.47 parts, and the other components and the method of preparation are the same as in example 1.
Test example 1
Evaluation of irritation
Testing a sample: examples 1-16 and comparative examples 1-2 provide sunscreen creams suitable for use in children and sensitive muscles.
Subject: the total number of 90 persons is 18, each group comprises 5 persons, each group is respectively tested with one sample, the male and female are unlimited, the age is 22-45 years, and the selection standard of the test subject is required to be met.
The operation method comprises the following steps: a little product was smeared with a cotton swab and left for 15 seconds at the lower canthus (0.5 g applied), lower lip (0.5 g applied), cheek (0.5 g applied), tip of tongue (0.1 g applied), score after 5 minutes and record the results.
Irritation scoring criteria: 1 minute-no irritation; slight itching occurs after 2 minutes to-5 minutes; slight itching after 3 minutes to 15 seconds; 4 minutes to 5 minutes for stabbing pain; 5 minutes to 15 seconds of stabbing pain.
The test results were averaged for each group and are shown in table 1 below:
TABLE 1
As can be seen from the data in Table 1, the sunscreen cream provided by the invention is safe and non-irritant, and is suitable for children and sensitive muscles.
Test example 2
SPF and PFA value test (ISO 24443)
Testing a sample: examples 1-16 and comparative examples 1-2 provide sunscreen creams suitable for use in children and sensitive muscles.
The instrument comprises the following steps: UV-2000S ultraviolet transmissivity analyzer
The test method comprises the following steps: 1.3mg/cm 2 The sun-proof sample is smeared on a PMMA plate with the size of 5cm multiplied by 2.5cm and the roughness of 6 mu m, the state that the sample is smeared on the surface of the skin is simulated, and the sun-proof standing is carried out for 30min; testing the absorption spectrum of the sun-proof sample before ultraviolet irradiation by using a spectrophotometer and calculating an in-vitro SPF value; correcting the absorption spectrum by using a correction factor C to enable the in-vitro SPF value to be equal to the SPF value obtained by a human body method, and calculating a UVA protection factor (UVAPF 0) before irradiation; with 1.2X UVAPF0 (J/cm) 2 ) The sample is irradiated by ultraviolet rays with dosage, and an ultraviolet absorption spectrum after irradiation is tested, and the UVA protection factor (UVAPF value) of the sample is obtained through calculation.
The test results are shown in table 2 below:
TABLE 2
As can be seen from the data in Table 2, the sunscreen cream provided by the invention has excellent sunscreen efficacy and is suitable for children and sensitive muscles.
As can be seen by comparing example 1 with examples 4-6, the absence of any of the complex-PC, sodium surfactin or sucrose laurate in the water-soluble emulsifier results in uneven dispersion of the sunscreen agent and thus a reduction in the sunscreen capacity of the final sunscreen composition.
It is seen from a comparison of example 1 and examples 7-9 that the absence of any of glycerin, hydroxyethyl urea or betaine in the moisturizer affects the moisturization and, in turn, the sunscreen performance of the sunscreen.
As can be seen from the comparison between example 1 and examples 10-12, the dimethicone, coco-caprylate/caprate and cetearyl alcohol in the oil cooperate with each other to synergistically enhance the effect, so that a layer of sunscreen protective film can be rapidly formed on the surface of the skin, and the service efficiency of the sunscreen is improved.
As can be seen from a comparison of example 1 and example 16, the addition of the encapsulated sunscreen agent at high temperature results in the shell being affected by the high temperature causing the organic sunscreen agent to precipitate and thereby affecting the sunscreen effect.
It can be seen from a comparison of example 1 and comparative example 1 that the use of exposed sunscreen agents will affect the sunscreen effect.
As can be seen from a comparison of example 1 and comparative example 2, the lack of addition of an emulsifying thickener results in uneven emulsification and an adverse effect on the sunscreen effect.
Test example 3
UV Damage test
Testing a sample: examples 1-16 and comparative examples 1-2 provide sunscreen creams suitable for use on children and sensitive muscles.
Scientific studies have shown that, following UV irradiation, the transdermal Water Loss (TEWL) of the skin increases, barrier function is impaired, the skin becomes dry, and sunburn cells are produced. The samples prepared in examples 1 to 16 and comparative examples 1 to 2 were tested in this test example, and blank substrate products each without a photo-protective additive were used as blanks.
90 volunteers 23-34 years old were selected for human testing and divided into 18 groups of 5 individuals each. Selecting thigh skin to test TEWL, then using the test sample and a blank control sample respectively twice a day, once in the morning and at night, using 15d, carrying out full spectrum irradiation on the thigh skin for 6h according to the lowest erythema dose of the skin of a volunteer, testing the TEWL, and calculating the TEWL rising value reduction rate by taking the blank control as a reference. And (3) continuing full-spectrum irradiation on the thigh skin for 18h, observing and counting the sunburn cells by using a confocal microscope, calculating the sunburn cell reduction rate, and taking the average value of each group according to the test result, wherein the result is shown in table 3.
The formula for the rate of decrease of the TEWL rise is as follows:
a TEWL increase decrease rate (%) = [ blank control TEWL value difference-sample TEWL value difference)/blank control TEWL value difference ] × 100%;
the formula for the reduction rate of sunburn cells is as follows:
sun burn cell reduction (%) = (number of blank sun burn cells-number of sample sun burn cells)/number of blank sun burn cells) × 100%.
TABLE 3
As can be seen from the data in Table 3, the wrapping sun-screening agent, the water-soluble emulsifier, the humectant, the oil and the antioxidant are matched with each other, have synergistic interaction and are matched with a specific preparation process, so that the TEWL rise value reduction rate and the sunburn cell reduction rate are improved.
Test example 4
Oxidation resistance test
Testing a sample: examples 1, 13-15 provide sunscreen creams suitable for use on children and sensitive muscles.
DPPH free radical is a stable free radical, and whether the tested substance has oxidation resistance can be determined by utilizing the characteristic that ethanol solution of DPPH free radical is purple and has a characteristic absorption peak at the wavelength of 517 nm. Transferring 2mL of DPPH-ethanol solution (0.2 mmol/L), adding 2mL of a sample to be detected, fully mixing, standing in a dark place for 30min, taking absolute ethyl alcohol as a blank control, measuring the absorbance at 517nm, and calculating the DPPH clearance rate of the sample to be detected according to the following formula:
DPPH clearance (%) = [1- (a) i -A j )/A 0 ]×100%
In the formula, A i Absorbance of the sample to be measured in the DPPH reaction System, A j Is the absorbance of the sample to be measured after mixing with absolute ethyl alcohol, A 0 The absorbance of the blank control absolute ethyl alcohol is shown.
The ability of the double-layer essence to scavenge DPPH free radicals was tested according to the above method, and the specific data are shown in Table 4:
TABLE 4
Test specimen | DPPH clearance (%) |
Example 1 | 96.4% |
Example 13 | 80.6% |
Example 14 | 72.6% |
Example 15 | 70.3% |
As can be seen from a comparison of example 1 and examples 13-15, tocopherol, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and tert-butylhydroquinone cooperate with each other to synergistically enhance the antioxidant properties of the sunscreen.
Test example 5
Photostability test
Testing a sample: examples 1-16 and comparative examples 1-2 provide sunscreen creams suitable for use in children and sensitive muscles.
The test method comprises the following steps: 0.20g of the sunscreen suitable for children and sensitive muscles provided in examples 1-16 and comparative examples 1-2, respectively, was placed on a glass slide, which was exposed to ATLAS Ci3000+ sun-aging machine and removed after an exposure period of 0 (blank, no exposure) and 6 h. And (3) washing the sunscreen cream on the glass slide with chromatographic grade methanol, fixing the volume in a 25mL volumetric flask, and testing the content of the butyl methoxydibenzoylmethane by Agilent1260 high performance liquid chromatography.
The butyl methoxydibenzoylmethane (%) remaining after 6h exposure was calculated according to the following formula;
butyl methoxydibenzoylmethane (%) remaining after 6h exposure (= [ butyl methoxydibenzoylmethane content after 6h exposure/butyl methoxydibenzoylmethane content after 0h exposure ] × 100%;
the results of the experiment are shown in table 5 below:
TABLE 5
As can be seen from the data in Table 5, the sun-screening agent, the water-soluble emulsifier, the humectant, the oil and the antioxidant are matched with each other, have synergistic interaction and are matched with a specific preparation process, so that the light stability of the sun-screening cream suitable for children and sensitive muscles is improved, and the light degradation degree of the coated organic sun-screening agent is reduced.
The applicant states that the present invention is illustrated by the above examples, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be implemented by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. A sunscreen cream suitable for children and sensitive muscles is characterized in that the sunscreen cream suitable for children and sensitive muscles comprises an organic wrapping sunscreen agent, an emulsifier, a thickener, a humectant, grease and a solvent; the emulsifier comprises a water-soluble emulsifier and an oil-soluble emulsifier, and the thickener comprises an aqueous thickener and an emulsifying thickener.
2. The sunscreen cream suitable for children and sensitive muscles according to claim 1, which comprises, by weight, 1-30 parts of a wrapping organic sunscreen agent, 0.1-5 parts of a water-soluble emulsifier, 0.05-2 parts of an oil-soluble emulsifier, 0.05-1 part of an aqueous thickener, 0.1-5 parts of an emulsifying thickener, 0.1-15 parts of a humectant, 0.1-15 parts of grease and 30-80 parts of a solvent.
3. The sunscreen cream suitable for children and sensitive muscles according to claim 1 or 2, wherein the shell encapsulating the organic sunscreen agent comprises any one or a combination of at least two of silicone-based substances, silica, phospholipids-based substances, polymethyl methacrylate-based substances, or cellulose-based polymers;
preferably, the polysiloxane comprises any one of polysiloxane-11, polysiloxane-13, polysiloxane-14 or polysiloxane-15 or a combination of at least two of the same;
preferably, the phospholipid material comprises any one or a combination of at least two of phospholipid, lecithin or hydrogenated lecithin;
preferably, the polymethyl methacrylate substance comprises polymethyl methacrylate and/or polymethyl methacrylate crosslinked polymer;
preferably, the cellulosic polymer class comprises any one or a combination of at least two of cellulose acetate butyrate, cellulose acetate propionate or cellulose acetate;
preferably, the organic sunscreen agent in the coated organic sunscreen agent comprises any one or a combination of at least two of butyl methoxydibenzoylmethane, octocrylene, ethylhexyl methoxycinnamate or hexyl diethylamino hydroxybenzoyl benzoate;
preferably, the mass ratio of the shell wrapping the organic sunscreen agent to the organic sunscreen agent is (1-70) to (1-60);
4. The sunscreen cream suitable for children and sensitive muscles according to any one of claims 1 to 3, wherein the water-soluble emulsifier comprises any one or a combination of at least two of phospholipid emulsifiers, amino acid emulsifiers or sucrose ester emulsifiers, preferably phospholipid emulsifiers, amino acid emulsifiers and sucrose ester emulsifiers;
preferably, the mass ratio of the phospholipid emulsifier to the amino acid emulsifier to the sucrose ester emulsifier is (1-3): 0.05-0.15): 0.15-0.25;
preferably, the phospholipid emulsifier comprises hydrogenated lecithin;
preferably, the phospholipid emulsifier is selected from any one or a combination of at least two of phytompo-PP, compsite-PC, compsite-C3, phytompo-C5, phytompo-SP, phytompo-SC or Compsite-C4;
preferably, the amino acid-based emulsifier is selected from surfactin sodium and/or inulin lauryl carbamate;
preferably, the sucrose ester-based emulsifier is selected from any one of, or a combination of at least two of, sucrose palmitate, sucrose myristate, sucrose laurate or sucrose oleate;
preferably, the oil-soluble emulsifier is selected from polyglycerine-type emulsifiers;
preferably, the polyglycerol-based emulsifier is selected from any one of or a combination of at least two of polyglycerol-3 diisostearate, polyglycerol-2 oleate, polyglycerol-2 triisostearate, polyglycerol-4 isostearate, polyglycerol-3 polyricinoleate, polyglycerol-3 ricinoleate or polyhydroxystearic acid.
5. The sunscreen cream suitable for children and sensitive muscles according to any one of claims 1 to 4, wherein the aqueous thickener is selected from any one or a combination of at least two of carbomer, acrylic acid/C10-30 alkanol acrylate crosspolymer, xanthan gum, magnesium aluminum silicate, lithium magnesium silicate, sodium polyacryl dimethyl taurate, microcrystalline cellulose, carob bean gum, crinkle grass extract, sodium polyacrylate, hydroxyethyl cellulose, sodium polyacrylate grafted starch, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer or polyacrylate-13;
preferably, the emulsifying thickener is selected from any one or a combination of at least two of sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylamide, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, acrylamide and acrylamide copolymer, polyisobutylene, xanthan gum, ammonium acryloyldimethyl taurate/VP copolymer or acrylic acid (ester) -based cross-linked polymer-2;
preferably, the emulsifying thickener is selected from any one or a combination of at least two of SIMULGEL EG, SEPIGEL 305, SEPINOV EMT 10, SEPIPLUS 265, SIMULGEL NS, SEPIPLUS 400, SEPINOV WEO, SIMULGEL INS 100, SILIGEL, aristoflex AVC, or AQUA KEEP 10 SH-NFC.
6. Sunscreen cream suitable for use in children and sensitive muscles according to any of claims 1-5, characterized in that the moisturizer is selected from any one or a combination of at least two of glycerol, hydroxyethyl urea, betaine, propylene glycol, methyl propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, octyl glycol, ethylhexyl glycerol, polyethylene glycols or sorbitol, preferably glycerol, hydroxyethyl urea and betaine;
preferably, the mass ratio of the glycerol to the hydroxyethyl urea to the betaine is (3-5) to (1-3);
preferably, the oil is selected from any one or a combination of at least two of polydimethylsiloxane, butanediol dicaprylate/dicaprate, squalane, hydrogenated polyisobutene, phytosterols, behenyl alcohol, cetearyl alcohol, cetyl alcohol, C12-15 alcohol benzoate, coco alcohol-caprylate/caprate, octyl methicone, isononyl isononanoate or butyl octanol salicylate, preferably polydimethylsiloxane, coco alcohol-caprylate/caprate and cetearyl alcohol;
preferably, the mass ratio of the polydimethylsiloxane, the coco-caprylate/caprate and the cetearyl alcohol is (2-4): (1-3): (0.1-0.5).
7. The sunscreen suitable for children and sensitive muscles according to any one of claims 1 to 6, characterized in that it further comprises 0.01 to 1 part by weight of an antioxidant selected from any one or a combination of at least two of tocopherol, butylated hydroxytoluene, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate), tris (tetramethylhydroxypiperidinol) citrate, or tert-butylhydroquinone, preferably tocopherol, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and tert-butylhydroquinone;
preferably, the mass ratio of the tocopherol to the pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and tert-butylhydroquinone is (0.05-0.15): (0.05-0.15);
preferably, the sunscreen cream suitable for children and sensitive muscles further comprises 0.01-1 part of pH regulator by weight, wherein the pH regulator comprises any one or combination of at least two of citric acid, sodium citrate, disodium hydrogen phosphate or sodium dihydrogen phosphate;
preferably, the solvent comprises water.
8. A method for preparing a sunscreen suitable for use on children and sensitive muscles according to any one of claims 1 to 7, characterized in that it comprises the following steps:
(1) Mixing a solvent, a water-soluble emulsifier, an aqueous thickener and a humectant to obtain a phase A; mixing oil and fat with an oil-soluble emulsifier to obtain a phase B;
(2) Mixing the phase A and the phase B obtained in the step (1), and homogenizing to obtain a phase C;
(3) And (3) mixing the phase C obtained in the step (2), an emulsifying thickener and a wrapping organic sunscreen agent to obtain the sunscreen cream suitable for children and sensitive muscles.
9. The method according to claim 8, wherein in the step (1), the temperature of the mixing is 50 to 70 ℃ in the operation of obtaining the phase A;
preferably, in the step (1), the temperature of the mixing is 50-70 ℃ in the operation of obtaining the phase B;
preferably, in the step (1), the operation of obtaining phase B further comprises an antioxidant.
10. The method for preparing a porous ceramic material according to claim 8 or 9, wherein the homogenization temperature in step (2) is 50-70 ℃;
preferably, in the step (3), the temperature of the mixing is 25-35 ℃;
preferably, in step (3), the mixing further comprises a pH adjuster.
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